| Friday, March 22 |
| Future Indian Dick Ellsworth is born in Lusk, WY. |
| Saturday, March 30 |
| Former Indian George McQuillan dies in Columbus, OH at the age of 55. |
| Tuesday, April 16 |
| » Defeated White Sox (0-1), 1-0 | Comiskey Park I (1-0) | 1-0 | |
| » Starters: Bob Feller vs Eddie Smith | First | -- |
| Friday, April 19 |
| » Defeated Tigers (1-2), 4-0 | Cleveland Stadium (1-0) | 2-0 | Won 2 |
| » Starters: Cotton Pippen vs Johnny Allen | First | -- |
| Sunday, April 21 |
| » Lost to Tigers (2-2), 12-2 | Cleveland Stadium (1-1) | 2-1 | |
| » Starters: Schoolboy Rowe vs Bob Feller | Second | ½ out |
| Monday, April 22 |
| » Defeated Browns (2-3), 5-2 | Sportsman's Park III (1-0) | 3-1 | |
| » Starters: Willis Hudlin vs Lefty Mills | First | -- |
| Wednesday, April 24 |
| » Defeated Browns (2-4), 6-4 | Sportsman's Park III (2-0) | 4-1 | Won 2 |
| » Starters: Al Milnar vs Vern Kennedy | First | -- |
| Thursday, April 25 |
| » Defeated White Sox (1-5), 3-1 | League Park II (1-0) | 5-1 | Won 3 |
| » Starters: Eddie Smith vs Bob Feller | First | -- |
| Friday, April 26 |
| » Lost to White Sox (2-5), 11-1 | League Park II (1-1) | 5-2 | |
| » Starters: Thornton Lee vs Johnny Allen | First | -- |
| Saturday, April 27 |
| » Defeated Tigers (5-3), 4-2 | Tiger Stadium (1-0) | 6-2 | |
| » Starters: Mike Naymick vs Hal Newhouser | First | -- |
| Sunday, April 28 |
| » Defeated Tigers (5-4), 11-9 | Tiger Stadium (2-0) | 7-2 | Won 2 |
| » Starters: Al Milnar vs Schoolboy Rowe | First | -- |
| » Major-league debuts: Frank Secory (Tigers) |
| Monday, April 29 |
| » Lost to Tigers (6-4), 4-3 | Tiger Stadium (2-1) | 7-3 | |
| » Starters: Bob Feller vs Cotton Pippen | First | -- |
| Tuesday, April 30 |
| » Defeated Athletics (4-8), 10-5 | Shibe Park (1-0) | 8-3 | |
| » Starters: Willis Hudlin vs Herman Besse | First | -- |
| Wednesday, May 1 |
| » Lost to Athletics (5-8), 5-1 | Shibe Park (1-1) | 8-4 | |
| » Starters: Johnny Allen vs Nels Potter | First | -- |
| Saturday, May 4 |
| » Defeated Senators (6-8), 12-4 | Griffith Stadium (1-0) | 9-4 | |
| » Starters: Al Milnar vs Ken Chase | Second | ½ out |
| Sunday, May 5 |
| » Defeated Red Sox (10-5), 6-1 | Fenway Park (1-0) | 10-4 | Won 2 |
| » Starters: Bob Feller vs Mickey Harris | First | -- |
| Monday, May 6 |
| » Lost to Red Sox (11-5), 8-5 | Fenway Park (1-1) | 10-5 | |
| » Starters: Willis Hudlin vs Emerson Dickman | Second | ½ out |
| Tuesday, May 7 |
| » Lost to Red Sox (12-5), 6-4 | Fenway Park (1-2) | 10-6 | Lost 2 |
| » Starters: Mike Naymick vs Lefty Grove | Third | 1½ out |
| Wednesday, May 8 |
| » Defeated Yankees (6-11), 10-4 | Yankee Stadium (1-0) | 11-6 | |
| » Starters: Al Smith vs Marv Breuer | Second | 1½ out |
| Thursday, May 9 |
| » Defeated Yankees (6-12), 4-0 | Yankee Stadium (2-0) | 12-6 | Won 2 |
| » Starters: Bob Feller vs Monte Pearson | Second | 1½ out |
| Friday, May 10 |
| » Defeated Browns (8-11), 9-4 | League Park II (2-1) | 13-6 | Won 3 |
| » Starters: Vern Kennedy vs Al Milnar | Second | 1½ out |
| Saturday, May 11 |
| » Defeated Browns (8-12), 1-0 | League Park II (3-1) | 14-6 | Won 4 |
| » Starters: Emil Bildilli vs Johnny Allen | Second | 1½ out |
| Sunday, May 12 |
| » Lost to Browns (9-12), 5-2 | Cleveland Stadium (1-2) | 14-7 | |
| » Starters: Elden Auker vs Willis Hudlin | Second | 1½ out |
| Future Indian Tom Timmermann is born in Breese, IL. |
| Tuesday, May 14 |
| » Lost to Athletics (11-12), 9-7 | League Park II (3-2) | 14-8 | Lost 2 |
| » Starters: Herman Besse vs Bob Feller | Second | 2½ out |
| Friday, May 17 |
| » Defeated Senators (10-14), 18-1 | League Park II (4-2) | 15-8 | |
| » Starters: Sid Hudson vs Al Milnar | Second | 2½ out |
| Saturday, May 18 |
| » Lost to Senators (11-14), 3-2 | League Park II (4-3) | 15-9 | |
| » Starters: Ken Chase vs Johnny Allen | Second | 3 out |
| Sunday, May 19 |
| » Defeated Yankees (9-15), 5-1 | Cleveland Stadium (2-2) | 16-9 | |
| » Starters: Red Ruffing vs Bob Feller | Second | 2½ out |
| Monday, May 20 |
| » Defeated Yankees (9-16), 10-2 | League Park II (5-3) | 17-9 | Won 2 |
| » Starters: Spud Chandler vs Al Smith | Second | 1½ out |
| Tuesday, May 21 |
| » Lost to Yankees (10-16), 10-2 | League Park II (5-4) | 17-10 | |
| » Starters: Marius Russo vs Al Milnar | Second | 2½ out |
| Wednesday, May 22 |
| » Defeated Red Sox (19-8), 9-6 | League Park II (6-4) | 18-10 | |
| » Starters: Fritz Ostermueller vs Mel Harder | Second | 1½ out |
| Friday, May 24 |
| » Defeated Browns (11-16), 3-2 | Sportsman's Park III (3-0) | 19-10 | Won 2 |
| » Starters: Bob Feller vs Elden Auker | Second | 1 out |
| Sunday, May 26 |
| » Lost to Browns (12-16), 5-3 | Sportsman's Park III (3-1) | 19-11 | |
| » Starters: Mel Harder vs Emil Bildilli | Second | 1½ out |
| » Defeated Browns (12-17), 13-1 | Sportsman's Park III (4-1) | 20-11 | |
| » Starters: Al Milnar vs Lefty Mills | Second | 1½ out |
| Monday, May 27 |
| » Lost to Tigers (17-14), 6-1 | Cleveland Stadium (2-3) | 20-12 | |
| » Starters: Bobo Newsom vs Mike Naymick | Second | 2 out |
| Tuesday, May 28 |
| » Lost to Tigers (18-14), 8-5 | League Park II (6-5) | 20-13 | Lost 2 |
| » Starters: Hal Newhouser vs Johnny Allen | Second | 2 out |
| Wednesday, May 29 |
| » Defeated Tigers (18-15), 7-4 | League Park II (7-5) | 21-13 | |
| » Starters: Tom Seats vs Bob Feller | Second | 2 out |
| Thursday, May 30 |
| » Defeated White Sox (16-20), 3-1 | Cleveland Stadium (3-3) | 22-13 | Won 2 |
| » Starters: Eddie Smith vs Al Smith | Second | 2 out |
| » Defeated White Sox (16-21), 3-1 | Cleveland Stadium (4-3) | 23-13 | Won 3 |
| » Starters: Thornton Lee vs Al Milnar | Second | 2 out |
| Saturday, June 1 |
| » Lost to Athletics (14-21), 6-1 | Shibe Park (1-2) | 23-14 | |
| » Starters: Johnny Allen vs Buck Ross | Second | 2 out |
| Sunday, June 2 |
| » Defeated Athletics (14-22), 7-2 | Shibe Park (2-2) | 24-14 | |
| » Starters: Bob Feller vs Nels Potter | Second | 2 out |
| » Lost to Athletics (15-22), 12-6 | Shibe Park (2-3) | 24-15 | |
| » Starters: Mike Naymick vs Johnny Babich | Second | 2 out |
| Monday, June 3 |
| » Defeated Athletics (15-23), 4-0 | Shibe Park (3-3) | 25-15 | |
| » Starters: Al Milnar vs Chubby Dean | Second | 2 out |
| Tuesday, June 4 |
| » Lost to Senators (18-24), 7-2 | Griffith Stadium (1-1) | 25-16 | |
| » Starters: Mel Harder vs Ken Chase | Second | 2½ out |
| » Defeated Senators (18-25), 3-2 | Griffith Stadium (2-1) | 26-16 | |
| » Starters: Al Smith vs Joe Haynes | Second | 2½ out |
| Wednesday, June 5 |
| » Lost to Senators (19-25), 6-1 | Griffith Stadium (2-2) | 26-17 | |
| » Starters: Joe Dobson vs Walt Masterson | Second | 2½ out |
| Thursday, June 6 |
| » Defeated Senators (19-26), 5-4 | Griffith Stadium (3-2) | 27-17 | |
| » Starters: Johnny Allen vs Sid Hudson | Second | 2½ out |
| Friday, June 7 |
| » Lost to Yankees (23-20), 5-4 | Yankee Stadium (2-1) | 27-18 | |
| » Starters: Bob Feller vs Marv Breuer | Second | 2½ out |
| Saturday, June 8 |
| » Defeated Yankees (23-21), 3-0 | Yankee Stadium (3-1) | 28-18 | |
| » Starters: Al Milnar vs Marius Russo | Second | 2½ out |
| Sunday, June 9 |
| » Lost to Yankees (24-21), 4-3 | Yankee Stadium (3-2) | 28-19 | |
| » Starters: Al Smith vs Red Ruffing | Second | 3 out |
| Tuesday, June 11 |
| » Lost to Red Sox (26-16), 9-2 | Fenway Park (1-3) | 28-20 | Lost 2 |
| » Starters: Bob Feller vs Jack Wilson | Third | 3 out |
| Wednesday, June 12 |
| » Lost to Red Sox (27-16), 9-5 | Fenway Park (1-4) | 28-21 | Lost 3 |
| » Starters: Al Milnar vs Mickey Harris | Third | 3 out |
| Thursday, June 13 |
| » Defeated Tigers (26-20), 3-2 | League Park II (8-5) | 29-21 | |
| » Starters: Schoolboy Rowe vs Al Smith | Second | 3½ out |
| Friday, June 14 |
| » Defeated Athletics (19-29), 8-0 | League Park II (9-5) | 30-21 | Won 2 |
| » Starters: Chubby Dean vs Johnny Allen | Second | 3½ out |
| Saturday, June 15 |
| » Lost to Athletics (20-29), 7-4 | League Park II (9-6) | 30-22 | |
| » Starters: Buck Ross vs Mel Harder | Third | 3½ out |
| » Major-league debuts: Crash Davis (Athletics) |
| Sunday, June 16 |
| » Defeated Athletics (20-30), 4-2 | Cleveland Stadium (5-3) | 31-22 | |
| » Starters: Porter Vaughan vs Bob Feller | Third | 3½ out |
| » Defeated Athletics (20-31), 4-3 | Cleveland Stadium (6-3) | 32-22 | Won 2 |
| » Starters: Johnny Babich vs Al Milnar | Third | 3½ out |
| Tuesday, June 18 |
| » Defeated Senators (21-35), 2-1 | Cleveland Stadium (7-3) | 33-22 | Won 3 |
| » Starters: Dutch Leonard vs Al Smith | Second | 3½ out |
| Wednesday, June 19 |
| » Defeated Senators (21-36), 4-1 | League Park II (10-6) | 34-22 | Won 4 |
| » Starters: Ken Chase vs Johnny Allen | Third | 3½ out |
| Thursday, June 20 |
| » Defeated Senators (21-37), 12-1 | League Park II (11-6) | 35-22 | Won 5 |
| » Starters: Walt Masterson vs Bob Feller | First | -- |
| Friday, June 21 |
| » Defeated Red Sox (31-21), 7-4 | League Park II (12-6) | 36-22 | Won 6 |
| » Starters: Jack Wilson vs Al Milnar | First | -- |
| Saturday, June 22 |
| » Defeated Red Sox (31-22), 7-5 | League Park II (13-6) | 37-22 | Won 7 |
| » Starters: Jim Bagby vs Mel Harder | First | -- |
| Sunday, June 23 |
| » Defeated Red Sox (31-23), 4-1 | Cleveland Stadium (8-3) | 38-22 | Won 8 |
| » Starters: Lefty Grove vs Al Smith | First | -- |
| » Lost to Red Sox (32-23), 2-0 | Cleveland Stadium (8-4) | 38-23 | |
| » Starters: Herb Hash vs Joe Dobson | First | -- |
| Monday, June 24 |
| » Defeated Yankees (28-30), 7-1 | Cleveland Stadium (9-4) | 39-23 | |
| » Starters: Marius Russo vs Bob Feller | First | -- |
| Former Indian Bert Adams dies in Los Angeles, CA at the age of 50. |
| Tuesday, June 25 |
| » Defeated Yankees (28-31), 5-3 | League Park II (14-6) | 40-23 | Won 2 |
| » Starters: Monte Pearson vs Al Milnar | First | -- |
| Wednesday, June 26 |
| » Lost to Yankees (29-31), 3-1 | League Park II (14-7) | 40-24 | |
| » Starters: Red Ruffing vs Mel Harder | First | -- |
| Saturday, June 29 |
| » Defeated White Sox (27-33), 7-3 | Comiskey Park I (2-0) | 41-24 | |
| » Starters: Bob Feller vs Thornton Lee | First | -- |
| Sunday, June 30 |
| » Defeated White Sox (27-34), 7-5 | Comiskey Park I (3-0) | 42-24 | Won 2 |
| » Starters: Al Smith vs Ted Lyons | First | -- |
| » Lost to White Sox (28-34), 3-1 | Comiskey Park I (3-1) | 42-25 | |
| » Starters: Al Milnar vs Eddie Smith | First | -- |
| Monday, July 1 |
| » Lost to Browns (32-37), 2-1 | Cleveland Stadium (9-5) | 42-26 | Lost 2 |
| » Starters: Elden Auker vs Joe Dobson | First | -- |
| Tuesday, July 2 |
| » Lost to Browns (33-37), 5-3 | League Park II (14-8) | 42-27 | Lost 3 |
| » Starters: Vern Kennedy vs Mel Harder | Second | 2 out |
| Wednesday, July 3 |
| » Defeated Browns (33-38), 5-2 | League Park II (15-8) | 43-27 | |
| » Starters: Bob Harris vs Bob Feller | First | -- |
| Thursday, July 4 |
| » Lost to Tigers (41-26), 5-3 | Tiger Stadium (2-2) | 43-28 | |
| » Starters: Al Smith vs Tommy Bridges | First | -- |
| » Defeated Tigers (41-27), 2-1 | Tiger Stadium (3-2) | 44-28 | |
| » Starters: Al Milnar vs Hal Newhouser | First | -- |
| Saturday, July 6 |
| » Defeated White Sox (32-37), 7-3 | League Park II (16-8) | 45-28 | Won 2 |
| » Starters: Bill Dietrich vs Mel Harder | First | -- |
| Sunday, July 7 |
| » Lost to White Sox (33-37), 3-1 | Cleveland Stadium (9-6) | 45-29 | |
| » Starters: Ted Lyons vs Bob Feller | Second | 1½ out |
| Thursday, July 11 |
| » Defeated Athletics (29-44), 8-5 | Shibe Park (4-3) | 46-29 | |
| » Starters: Al Milnar vs Chubby Dean | First | -- |
| Friday, July 12 |
| » Defeated Athletics (29-45), 1-0 | Shibe Park (5-3) | 47-29 | Won 2 |
| » Starters: Bob Feller vs Johnny Babich | First | -- |
| Saturday, July 13 |
| » Defeated Athletics (29-46), 6-4 | Shibe Park (6-3) | 48-29 | Won 3 |
| » Starters: Mel Harder vs Buck Ross | First | -- |
| Sunday, July 14 |
| » Lost to Senators (32-48), 6-5 | Griffith Stadium (3-3) | 48-30 | |
| » Starters: Al Smith vs Ken Chase | First | -- |
| Monday, July 15 |
| » Lost to Senators (33-48), 8-6 | Griffith Stadium (3-4) | 48-31 | Lost 2 |
| » Starters: Al Milnar vs Sid Hudson | Second | 1 out |
| Tuesday, July 16 |
| » Lost to Senators (34-48), 11-8 | Griffith Stadium (3-5) | 48-32 | Lost 3 |
| » Starters: Harry Eisenstat vs Joe Krakauskas | Second | 1 out |
| Wednesday, July 17 |
| » Lost to Yankees (42-37), 4-3 | Yankee Stadium (3-3) | 48-33 | Lost 4 |
| » Starters: Bob Feller vs Monte Pearson | First | -- |
| Thursday, July 18 |
| » Lost to Yankees (43-37), 9-6 | Yankee Stadium (3-4) | 48-34 | Lost 5 |
| » Starters: Al Milnar vs Spud Chandler | Second | ½ out |
| Friday, July 19 |
| » Lost to Yankees (44-37), 15-6 | Yankee Stadium (3-5) | 48-35 | Lost 6 |
| » Starters: Al Smith vs Lefty Gomez | Second | 1½ out |
| Saturday, July 20 |
| » Defeated Red Sox (47-36), 9-6 | Fenway Park (2-4) | 49-35 | |
| » Starters: Mel Harder vs Lefty Grove | Second | 1½ out |
| » Major-league debuts: Earl Johnson (Red Sox) |
| Sunday, July 21 |
| » Defeated Red Sox (47-37), 3-2 | Fenway Park (3-4) | 50-35 | Won 2 |
| » Starters: Bob Feller vs Jim Bagby | Second | 1½ out |
| » Defeated Red Sox (47-38), 2-0 | Fenway Park (4-4) | 51-35 | Won 3 |
| » Starters: Joe Dobson vs Fritz Ostermueller | Second | 1½ out |
| Tuesday, July 23 |
| » Defeated Athletics (33-52), 1-0 | Cleveland Stadium (10-6) | 52-35 | Won 4 |
| » Starters: Johnny Babich vs Al Milnar | Second | ½ out |
| Wednesday, July 24 |
| » Defeated Athletics (33-53), 7-6 | League Park II (17-8) | 53-35 | Won 5 |
| » Starters: Chubby Dean vs Al Smith | Second | ½ out |
| Thursday, July 25 |
| » Lost to Athletics (34-53), 7-6 | League Park II (17-9) | 53-36 | |
| » Starters: Buck Ross vs Mel Harder | Second | 1½ out |
| Friday, July 26 |
| » Defeated Senators (38-54), 13-2 | League Park II (18-9) | 54-36 | |
| » Starters: Rene Monteagudo vs Bob Feller | Second | ½ out |
| Saturday, July 27 |
| » Lost to Senators (39-54), 7-1 | League Park II (18-10) | 54-37 | |
| » Starters: Ken Chase vs Joe Dobson | Second | 2 out |
| Sunday, July 28 |
| » Defeated Senators (39-55), 6-3 | Cleveland Stadium (11-6) | 55-37 | |
| » Starters: Walt Masterson vs Al Milnar | Second | 1½ out |
| » Lost to Senators (40-55), 9-1 | Cleveland Stadium (11-7) | 55-38 | |
| » Starters: Sid Hudson vs Al Smith | Second | 1½ out |
| Tuesday, July 30 |
| » Defeated Red Sox (50-43), 2-1 | Cleveland Stadium (12-7) | 56-38 | |
| » Starters: Jim Bagby vs Bob Feller | First | -- |
| Wednesday, July 31 |
| » Defeated Red Sox (50-44), 12-11 | Cleveland Stadium (13-7) | 57-38 | Won 2 |
| » Starters: Denny Galehouse vs Joe Dobson | First | -- |
| Thursday, August 1 |
| » Lost to Red Sox (51-44), 5-2 | Cleveland Stadium (13-8) | 57-39 | |
| » Starters: Fritz Ostermueller vs Mel Harder | Second | 1 out |
| Friday, August 2 |
| » Lost to Yankees (49-46), 10-2 | Cleveland Stadium (13-9) | 57-40 | Lost 2 |
| » Starters: Marius Russo vs Al Milnar | Second | 1 out |
| Saturday, August 3 |
| » Defeated Yankees (49-47), 5-1 | Cleveland Stadium (14-9) | 58-40 | |
| » Starters: Lefty Gomez vs Al Smith | Second | 1½ out |
| Sunday, August 4 |
| » Defeated Yankees (49-48), 3-1 | Cleveland Stadium (15-9) | 59-40 | Won 2 |
| » Starters: Red Ruffing vs Bob Feller | Second | ½ out |
| Monday, August 5 |
| » Defeated White Sox (50-47), 10-1 | Comiskey Park I (4-1) | 60-40 | Won 3 |
| » Starters: Mel Harder vs Eddie Smith | First | -- |
| Tuesday, August 6 |
| » Lost to White Sox (51-47), 5-1 | Comiskey Park I (4-2) | 60-41 | |
| » Starters: Al Milnar vs Thornton Lee | Second | ½ out |
| » Defeated White Sox (51-48), 3-2 | Comiskey Park I (5-2) | 61-41 | |
| » Starters: Johnny Allen vs Bill Dietrich | Second | ½ out |
| Wednesday, August 7 |
| » Defeated White Sox (51-49), 9-3 | Comiskey Park I (6-2) | 62-41 | Won 2 |
| » Starters: Al Smith vs Johnny Rigney | Second | ½ out |
| Thursday, August 8 |
| » Defeated Browns (43-63), 7-4 | Sportsman's Park III (5-1) | 63-41 | Won 3 |
| » Starters: Bob Feller vs Vern Kennedy | Second | ½ out |
| » Lost to Browns (44-63), 2-1 | Sportsman's Park III (5-2) | 63-42 | |
| » Starters: Johnny Humphries vs Elden Auker | Second | ½ out |
| Friday, August 9 |
| » Lost to Browns (45-63), 4-3 | Sportsman's Park III (5-3) | 63-43 | Lost 2 |
| » Starters: Mel Harder vs John Whitehead | Second | ½ out |
| Sunday, August 11 |
| » Defeated Browns (45-64), 12-4 | Sportsman's Park III (6-3) | 64-43 | |
| » Starters: Al Milnar vs Willis Hudlin | First | -- |
| » Lost to Browns (46-64), 7-6 | Sportsman's Park III (6-4) | 64-44 | |
| » Starters: Johnny Allen vs Bob Harris | First | -- |
| Monday, August 12 |
| » Defeated Tigers (64-45), 8-5 | League Park II (19-10) | 65-44 | |
| » Starters: Hal Newhouser vs Bob Feller | First | -- |
| Tuesday, August 13 |
| » Defeated Tigers (64-46), 6-5 | League Park II (20-10) | 66-44 | Won 2 |
| » Starters: Johnny Gorsica vs Mel Harder | First | -- |
| Wednesday, August 14 |
| » Defeated White Sox (56-51), 4-0 | Cleveland Stadium (16-9) | 67-44 | Won 3 |
| » Starters: Eddie Smith vs Al Smith | First | -- |
| Thursday, August 15 |
| » Defeated White Sox (56-52), 5-4 | League Park II (21-10) | 68-44 | Won 4 |
| » Starters: Thornton Lee vs Al Milnar | First | -- |
| Friday, August 16 |
| » Defeated Browns (46-69), 8-3 | League Park II (22-10) | 69-44 | Won 5 |
| » Starters: Elden Auker vs Bob Feller | First | -- |
| Saturday, August 17 |
| » Lost to Browns (47-69), 2-1 | League Park II (22-11) | 69-45 | |
| » Starters: Johnny Niggeling vs Mel Harder | First | -- |
| Sunday, August 18 |
| » Tied Browns, 2-2 | Cleveland Stadium (16-9) | 69-45 | |
| » Starters: Vern Kennedy vs Al Smith | First | -- |
| Monday, August 19 |
| » Lost to Red Sox (63-52), 16-7 | Fenway Park (4-5) | 69-46 | Lost 2 |
| » Starters: Joe Dobson vs Joe Heving | First | -- |
| Tuesday, August 20 |
| » Defeated Red Sox (63-53), 11-6 | Fenway Park (5-5) | 70-46 | |
| » Starters: Bob Feller vs Jack Wilson | First | -- |
| Wednesday, August 21 |
| » Defeated Red Sox (63-54), 4-2 | Fenway Park (6-5) | 71-46 | Won 2 |
| » Starters: Mel Harder vs Fritz Ostermueller | First | -- |
| » Major-league debuts: Bill Fleming (Red Sox) |
| Thursday, August 22 |
| » Lost to Yankees (61-54), 15-2 | Yankee Stadium (3-6) | 71-47 | |
| » Starters: Al Milnar vs Marius Russo | First | -- |
| Friday, August 23 |
| » Lost to Yankees (62-54), 5-3 | Yankee Stadium (3-7) | 71-48 | Lost 2 |
| » Starters: Al Smith vs Steve Sundra | First | -- |
| Saturday, August 24 |
| » Lost to Yankees (63-54), 3-2 | Yankee Stadium (3-8) | 71-49 | Lost 3 |
| » Starters: Bob Feller vs Atley Donald | First | -- |
| Sunday, August 25 |
| » Lost to Senators (52-67), 5-4 | Griffith Stadium (3-6) | 71-50 | Lost 4 |
| » Starters: Johnny Allen vs Sid Hudson | First | -- |
| Monday, August 26 |
| » Defeated Senators (52-68), 4-3 | Griffith Stadium (4-6) | 72-50 | |
| » Starters: Mel Harder vs Dutch Leonard | First | -- |
| Friday, August 30 |
| » Defeated White Sox (64-59), 4-2 | Comiskey Park I (7-2) | 73-50 | Won 2 |
| » Starters: Bob Feller vs Thornton Lee | First | -- |
| Saturday, August 31 |
| » Defeated White Sox (64-60), 5-4 | Comiskey Park I (8-2) | 74-50 | Won 3 |
| » Starters: Al Smith vs Eddie Smith | First | -- |
| Sunday, September 1 |
| » Defeated White Sox (64-61), 7-4 | Comiskey Park I (9-2) | 75-50 | Won 4 |
| » Starters: Al Milnar vs Ted Lyons | First | -- |
| Monday, September 2 |
| » Lost to Browns (53-76), 2-1 | Cleveland Stadium (16-10) | 75-51 | |
| » Starters: Vern Kennedy vs Mel Harder | First | -- |
| » Lost to Browns (54-76), 3-0 | Cleveland Stadium (16-11) | 75-52 | Lost 2 |
| » Starters: Elden Auker vs Johnny Allen | First | -- |
| Wednesday, September 4 |
| » Lost to Tigers (73-57), 7-2 | Tiger Stadium (3-3) | 75-53 | Lost 3 |
| » Starters: Bob Feller vs Schoolboy Rowe | First | -- |
| Thursday, September 5 |
| » Lost to Tigers (74-57), 11-3 | Tiger Stadium (3-4) | 75-54 | Lost 4 |
| » Starters: Al Smith vs Tommy Bridges | First | -- |
| Friday, September 6 |
| » Lost to Tigers (75-57), 10-5 | Tiger Stadium (3-5) | 75-55 | Lost 5 |
| » Starters: Johnny Allen vs Bobo Newsom | First | -- |
| Saturday, September 7 |
| » Lost to White Sox (70-62), 5-4 | Cleveland Stadium (16-12) | 75-56 | Lost 6 |
| » Starters: Bill Dietrich vs Mel Harder | First | -- |
| Sunday, September 8 |
| » Defeated White Sox (70-63), 5-4 | Cleveland Stadium (17-12) | 76-56 | |
| » Starters: Ted Lyons vs Al Milnar | First | -- |
| Monday, September 9 |
| » Lost to White Sox (71-63), 2-1 | Cleveland Stadium (17-13) | 76-57 | |
| » Starters: Thornton Lee vs Harry Eisenstat | Second | ½ out |
| Tuesday, September 10 |
| Future Indian Bob Chance is born in Statesboro, GA. |
| Wednesday, September 11 |
| » Lost to Yankees (76-58), 3-1 | Cleveland Stadium (17-14) | 76-58 | Lost 2 |
| » Starters: Tiny Bonham vs Bob Feller | Second | ½ out |
| » Defeated Yankees (76-59), 5-3 | Cleveland Stadium (18-14) | 77-58 | |
| » Starters: Red Ruffing vs Al Smith | Second | ½ out |
| Thursday, September 12 |
| » Defeated Red Sox (73-64), 8-1 | Cleveland Stadium (19-14) | 78-58 | Won 2 |
| » Starters: Fritz Ostermueller vs Mel Harder | Second | ½ out |
| » Major-league debuts: Tony Lupien (Red Sox) |
| Friday, September 13 |
| » Defeated Red Sox (73-65), 1-0 | Cleveland Stadium (20-14) | 79-58 | Won 3 |
| » Starters: Jim Bagby vs Al Milnar | Second | ½ out |
| Saturday, September 14 |
| » Lost to Red Sox (74-65), 6-1 | Cleveland Stadium (20-15) | 79-59 | |
| » Starters: Earl Johnson vs Johnny Allen | Second | ½ out |
| » Major-league debuts: Dixie Howell (Indians) |
| Sunday, September 15 |
| » Defeated Athletics (50-85), 5-0 | Cleveland Stadium (21-15) | 80-59 | |
| » Starters: Porter Vaughan vs Bob Feller | First | -- |
| » Defeated Athletics (50-86), 8-5 | Cleveland Stadium (22-15) | 81-59 | Won 2 |
| » Starters: George Caster vs Al Smith | First | -- |
| Monday, September 16 |
| » Defeated Athletics (50-87), 8-3 | Cleveland Stadium (23-15) | 82-59 | Won 3 |
| » Starters: Buck Ross vs Mel Harder | First | -- |
| » Lost to Athletics (51-87), 3-2 | Cleveland Stadium (23-16) | 82-60 | |
| » Starters: Johnny Babich vs Harry Eisenstat | First | -- |
| Tuesday, September 17 |
| » Lost to Athletics (52-87), 4-3 | Cleveland Stadium (23-17) | 82-61 | Lost 2 |
| » Starters: Bill Beckmann vs Al Milnar | Second | ½ out |
| Wednesday, September 18 |
| » Defeated Senators (60-83), 3-1 | Cleveland Stadium (24-17) | 83-61 | |
| » Starters: Ken Chase vs Johnny Allen | First | -- |
| » Defeated Senators (60-84), 2-1 | Cleveland Stadium (25-17) | 84-61 | Won 2 |
| » Starters: Sid Hudson vs Bob Feller | First | -- |
| Thursday, September 19 |
| » Defeated Senators (60-85), 3-1 | Cleveland Stadium (26-17) | 85-61 | Won 3 |
| » Starters: Dutch Leonard vs Al Smith | First | -- |
| Friday, September 20 |
| » Lost to Tigers (86-61), 6-5 | Tiger Stadium (3-6) | 85-62 | |
| » Starters: Mel Harder vs Bobo Newsom | Second | 1 out |
| Saturday, September 21 |
| » Lost to Tigers (87-61), 5-0 | Tiger Stadium (3-7) | 85-63 | Lost 2 |
| » Starters: Al Milnar vs Schoolboy Rowe | Second | 2 out |
| Sunday, September 22 |
| » Defeated Tigers (87-62), 10-5 | Tiger Stadium (4-7) | 86-63 | |
| » Starters: Bob Feller vs Tommy Bridges | Second | 1 out |
| Tuesday, September 24 |
| » Lost to Browns (66-84), 7-2 | Cleveland Stadium (26-18) | 86-64 | |
| » Starters: Elden Auker vs Mel Harder | Second | 1½ out |
| Wednesday, September 25 |
| » Defeated Browns (66-85), 4-2 | Cleveland Stadium (27-18) | 87-64 | |
| » Starters: Vern Kennedy vs Al Milnar | Second | 2 out |
| Friday, September 27 |
| » Lost to Tigers (90-62), 2-0 | Cleveland Stadium (27-19) | 87-65 | |
| » Starters: Floyd Giebell vs Bob Feller | Second | 3 out |
| Saturday, September 28 |
| » Defeated Tigers (90-63), 2-1 | Cleveland Stadium (28-19) | 88-65 | |
| » Starters: Johnny Gorsica vs Mel Harder | Second | 2 out |
| Sunday, September 29 |
| » Defeated Tigers (90-64), 3-2 | Cleveland Stadium (29-19) | 89-65 | Won 2 |
| » Starters: Dizzy Trout vs Al Milnar | Second | 1 out |
| Monday, October 14 |
| Future Indian Tommy Harper is born in Oak Grove, LA. |
| Monday, October 21 |
| Future Indian Ted Uhlaender is born in Chicago Heights, IL. |
| Wednesday, October 23 |
| Former Indian Harry Krause dies in San Francisco, CA at the age of 54. |
| Thursday, November 21 |
| Future Indian Tom McCraw is born in Malvern, AR. |
| Saturday, November 23 |
| Future Indian Luis Tiant, Jr. is born in Marianao, Cuba. |
Game information provided by Retrosheet (www.retrosheet.org) |
