| Wednesday, February 16 |
| Former White Sox Lee Tannehill dies in Live Oak, FL at the age of 58. |
| Sunday, March 20 |
| Former White Sox Bob Fothergill dies in Detroit, MI at the age of 41. |
| Wednesday, March 30 |
| Future White Sox Dave Baldwin is born in Tucson, AZ. |
| Saturday, April 2 |
| Future White Sox Al Weis is born in Franklin Square, NY. |
| Tuesday, April 5 |
| Future White Sox Ron Hansen is born in Oxford, NE. |
| Monday, April 18 |
| » Major-league debuts: Taffy Wright (Senators) |
| Tuesday, April 19 |
| » Defeated Tigers (0-1), 4-3 | Comiskey Park I (1-0) | 1-0 | |
| » Starters: Roxie Lawson vs John Whitehead | Second | ½ out |
| » Major-league debuts: Roy Cullenbine and Don Ross (Tigers) |
| Wednesday, April 20 |
| » Defeated Tigers (0-2), 5-4 | Comiskey Park I (2-0) | 2-0 | Won 2 |
| » Starters: Vern Kennedy vs Sugar Cain | Second | ½ out |
| » Major-league debuts: Mark Christman (Tigers) |
| Thursday, April 21 |
| » Lost to Tigers (1-2), 9-3 | Comiskey Park I (2-1) | 2-1 | |
| » Starters: Elden Auker vs Bill Dietrich | Third | 1 out |
| Friday, April 22 |
| » Defeated Browns (1-3), 4-3 | Sportsman's Park III (1-0) | 3-1 | |
| » Starters: Thornton Lee vs Oral Hildebrand | First | -- |
| Saturday, April 23 |
| » Lost to Browns (2-3), 5-4 | Sportsman's Park III (1-1) | 3-2 | |
| » Starters: Ted Lyons vs Bobo Newsom | Second | 1 out |
| Sunday, April 24 |
| » Lost to Browns (3-3), 4-3 | Sportsman's Park III (1-2) | 3-3 | Lost 2 |
| » Starters: John Whitehead vs Jim Walkup | Third | 2 out |
| Tuesday, April 26 |
| » Lost to Indians (6-1), 10-6 | Comiskey Park I (2-2) | 3-4 | Lost 3 |
| » Starters: Earl Whitehill vs Sugar Cain | Fourth | 3 out |
| Wednesday, April 27 |
| » Defeated Indians (6-2), 6-3 | Comiskey Park I (3-2) | 4-4 | |
| » Starters: Mel Harder vs Thornton Lee | Fourth | 2 out |
| Friday, April 29 |
| » Lost to Tigers (4-6), 5-1 | Tiger Stadium (0-1) | 4-5 | |
| » Starters: Johnny Rigney vs Boots Poffenberger | Fifth | 3½ out |
| Saturday, April 30 |
| » Defeated Browns (4-8), 3-0 | Comiskey Park I (4-2) | 5-5 | |
| » Starters: Jack Knott vs Ted Lyons | Fifth | 2½ out |
| Sunday, May 1 |
| » Lost to Browns (5-8), 7-5 | Comiskey Park I (4-3) | 5-6 | |
| » Starters: Bobo Newsom vs Thornton Lee | Fifth | 3½ out |
| Tuesday, May 3 |
| » Lost to Athletics (5-8), 7-2 | Shibe Park (0-1) | 5-7 | Lost 2 |
| » Starters: Sugar Cain vs Buck Ross | Fifth | 5 out |
| Wednesday, May 4 |
| » Defeated Athletics (5-9), 4-1 | Shibe Park (1-1) | 6-7 | |
| » Starters: Bill Dietrich vs George Caster | Fifth | 4 out |
| Thursday, May 5 |
| » Defeated Athletics (5-10), 10-4 | Shibe Park (2-1) | 7-7 | Won 2 |
| » Starters: Frank Gabler vs Bud Thomas | Fourth | 3 out |
| Friday, May 6 |
| » Lost to Senators (11-7), 4-3 | Griffith Stadium (0-1) | 7-8 | |
| » Starters: Thornton Lee vs Monte Weaver | Fourth | 4 out |
| Saturday, May 7 |
| » Lost to Senators (12-7), 5-4 | Griffith Stadium (0-2) | 7-9 | Lost 2 |
| » Starters: Ted Lyons vs Jimmie DeShong | Fourth | 5 out |
| Sunday, May 8 |
| » Lost to Yankees (13-7), 7-3 | Yankee Stadium (0-1) | 7-10 | Lost 3 |
| » Starters: Bill Dietrich vs Red Ruffing | Fourth | 5 out |
| Wednesday, May 11 |
| » Lost to Red Sox (13-8), 4-2 | Fenway Park (0-1) | 7-11 | Lost 4 |
| » Starters: Frank Gabler vs Lefty Grove | Fifth | 5½ out |
| Friday, May 13 |
| » Defeated Indians (14-9), 7-6 | League Park II (1-0) | 8-11 | |
| » Starters: Thornton Lee vs Willis Hudlin | Fifth | 5 out |
| Thursday, May 19 |
| » Defeated Red Sox (16-9), 4-0 | Comiskey Park I (5-3) | 9-11 | Won 2 |
| » Starters: Jack Wilson vs John Whitehead | Fifth | 5½ out |
| Saturday, May 21 |
| » Lost to Yankees (16-9), 1-0 | Comiskey Park I (5-4) | 9-12 | |
| » Starters: Spud Chandler vs Thornton Lee | Sixth | 6 out |
| Sunday, May 22 |
| » Defeated Senators (18-15), 9-2 | Comiskey Park I (6-4) | 10-12 | |
| » Starters: Wes Ferrell vs Ted Lyons | Sixth | 6 out |
| Tuesday, May 24 |
| » Defeated Senators (18-16), 10-3 | Comiskey Park I (7-4) | 11-12 | Won 2 |
| » Starters: Dutch Leonard vs Monty Stratton | Fifth | 6 out |
| Wednesday, May 25 |
| » Defeated Athletics (10-19), 7-4 | Comiskey Park I (8-4) | 12-12 | Won 3 |
| » Starters: Bud Thomas vs John Whitehead | Fifth | 6 out |
| Thursday, May 26 |
| » Lost to Athletics (11-19), 4-1 | Comiskey Park I (8-5) | 12-13 | |
| » Starters: George Caster vs Bill Dietrich | Fifth | 6 out |
| Friday, May 27 |
| » Lost to Tigers (15-17), 5-2 | Comiskey Park I (8-6) | 12-14 | Lost 2 |
| » Starters: Vern Kennedy vs Frank Gabler | Sixth | 6½ out |
| Saturday, May 28 |
| » Lost to Tigers (16-17), 9-1 | Comiskey Park I (8-7) | 12-15 | Lost 3 |
| » Starters: Tommy Bridges vs Bill Cox | Sixth | 7 out |
| Sunday, May 29 |
| » Lost to Tigers (17-17), 2-1 | Comiskey Park I (8-8) | 12-16 | Lost 4 |
| » Starters: Boots Poffenberger vs Monty Stratton | Sixth | 7 out |
| Monday, May 30 |
| » Lost to Indians (23-12), 5-2 | League Park II (1-1) | 12-17 | Lost 5 |
| » Starters: Ted Lyons vs Bob Feller | Seventh | 9 out |
| » Lost to Indians (24-12), 8-1 | League Park II (1-2) | 12-18 | Lost 6 |
| » Starters: Thornton Lee vs Johnny Allen | Seventh | 9 out |
| Wednesday, June 1 |
| » Lost to Senators (23-18), 5-4 | Griffith Stadium (0-3) | 12-19 | Lost 7 |
| » Starters: John Whitehead vs Jimmie DeShong | Seventh | 9 out |
| Thursday, June 2 |
| » Lost to Senators (24-18), 7-1 | Griffith Stadium (0-4) | 12-20 | Lost 8 |
| » Starters: Frank Gabler vs Dutch Leonard | Seventh | 10 out |
| Friday, June 3 |
| » Lost to Senators (25-18), 5-1 | Griffith Stadium (0-5) | 12-21 | Lost 9 |
| » Starters: Thornton Lee vs Wes Ferrell | Seventh | 11 out |
| Saturday, June 4 |
| » Lost to Athletics (16-22), 9-4 | Shibe Park (2-2) | 12-22 | Lost 10 |
| » Starters: Ted Lyons vs George Caster | Seventh | 12 out |
| Sunday, June 5 |
| » Defeated Athletics (16-23), 8-2 | Shibe Park (3-2) | 13-22 | |
| » Starters: Monty Stratton vs Eddie Smith | Seventh | 12½ out |
| » Lost to Athletics (17-23), 7-6 | Shibe Park (3-3) | 13-23 | |
| » Starters: John Whitehead vs Lynn Nelson | Seventh | 12½ out |
| Tuesday, June 7 |
| » Defeated Yankees (24-17), 8-5 | Yankee Stadium (1-1) | 14-23 | |
| » Starters: Thornton Lee vs Red Ruffing | Seventh | 12 out |
| Wednesday, June 8 |
| » Defeated Yankees (24-18), 11-10 | Yankee Stadium (2-1) | 15-23 | Won 2 |
| » Starters: Frank Gabler vs Spud Chandler | Fifth | 10½ out |
| » Defeated Yankees (24-19), 10-6 | Yankee Stadium (3-1) | 16-23 | Won 3 |
| » Starters: Bill Dietrich vs Monte Pearson | Fifth | 10½ out |
| Thursday, June 9 |
| » Lost to Yankees (25-19), 5-3 | Yankee Stadium (3-2) | 16-24 | |
| » Starters: John Whitehead vs Joe Beggs | Sixth | 10½ out |
| Friday, June 10 |
| » Defeated Red Sox (25-20), 15-2 | Fenway Park (1-1) | 17-24 | |
| » Starters: Monty Stratton vs Charlie Wagner | Sixth | 9½ out |
| » Major-league debuts: Bill Lefebvre (Red Sox) |
| Sunday, June 12 |
| » Lost to Red Sox (26-20), 3-2 | Fenway Park (1-2) | 17-25 | |
| » Starters: Ted Lyons vs Jack Wilson | Seventh | 9 out |
| » Defeated Red Sox (26-21), 4-3 | Fenway Park (2-2) | 18-25 | |
| » Starters: Bill Dietrich vs Johnny Marcum | Seventh | 9 out |
| Tuesday, June 14 |
| » Lost to Yankees (28-19), 7-4 | Comiskey Park I (8-9) | 18-26 | |
| » Starters: Spud Chandler vs Thornton Lee | Seventh | 9 out |
| Wednesday, June 15 |
| » Lost to Yankees (29-19), 6-4 | Comiskey Park I (8-10) | 18-27 | Lost 2 |
| » Starters: Joe Beggs vs John Whitehead | Seventh | 10 out |
| Thursday, June 16 |
| » Lost to Yankees (30-19), 5-1 | Comiskey Park I (8-11) | 18-28 | Lost 3 |
| » Starters: Monte Pearson vs Monty Stratton | Seventh | 11 out |
| Friday, June 17 |
| » Lost to Red Sox (30-21), 5-1 | Comiskey Park I (8-12) | 18-29 | Lost 4 |
| » Starters: Jack Wilson vs Jack Knott | Seventh | 12 out |
| Saturday, June 18 |
| » Lost to Red Sox (31-21), 4-3 | Comiskey Park I (8-13) | 18-30 | Lost 5 |
| » Starters: Lefty Grove vs Ted Lyons | Seventh | 12 out |
| Sunday, June 19 |
| » Defeated Red Sox (31-22), 3-2 | Comiskey Park I (9-13) | 19-30 | |
| » Starters: Johnny Marcum vs John Whitehead | Seventh | 12½ out |
| » Lost to Red Sox (32-22), 6-1 | Comiskey Park I (9-14) | 19-31 | |
| » Starters: Jim Bagby vs Bill Dietrich | Seventh | 12½ out |
| Tuesday, June 21 |
| » Lost to Senators (31-29), 7-0 | Comiskey Park I (9-15) | 19-32 | Lost 2 |
| » Starters: Harry Kelley vs Thornton Lee | Seventh | 13½ out |
| Wednesday, June 22 |
| » Defeated Senators (31-30), 16-3 | Comiskey Park I (10-15) | 20-32 | |
| » Starters: Wes Ferrell vs Monty Stratton | Seventh | 14 out |
| Thursday, June 23 |
| » Lost to Senators (32-30), 12-0 | Comiskey Park I (10-16) | 20-33 | |
| » Starters: Dutch Leonard vs John Whitehead | Seventh | 14 out |
| Monday, June 27 |
| » Defeated Browns (19-39), 9-4 | Sportsman's Park III (2-2) | 21-33 | |
| » Starters: Ted Lyons vs Bill Cox | Seventh | 14½ out |
| Tuesday, June 28 |
| » Defeated Browns (19-40), 10-9 | Sportsman's Park III (3-2) | 22-33 | Won 2 |
| » Starters: Thornton Lee vs Jim Walkup | Seventh | 14½ out |
| Wednesday, June 29 |
| » Defeated Browns (19-41), 9-5 | Sportsman's Park III (4-2) | 23-33 | Won 3 |
| » Starters: Monty Stratton vs Oral Hildebrand | Seventh | 13½ out |
| Thursday, June 30 |
| » Defeated Browns (19-42), 11-1 | Sportsman's Park III (5-2) | 24-33 | Won 4 |
| » Starters: Jack Knott vs Bobo Newsom | Seventh | 13½ out |
| Sunday, July 3 |
| » Lost to Indians (41-22), 2-1 | Comiskey Park I (10-17) | 24-34 | |
| » Starters: Johnny Allen vs Ted Lyons | Seventh | 13½ out |
| » Defeated Indians (41-23), 3-0 | Comiskey Park I (11-17) | 25-34 | |
| » Starters: Johnny Humphries vs Thornton Lee | Seventh | 13½ out |
| Monday, July 4 |
| » Defeated Browns (22-43), 5-4 | Comiskey Park I (12-17) | 26-34 | Won 2 |
| » Starters: Jim Walkup vs John Whitehead | Fifth | 11½ out |
| » Defeated Browns (22-44), 5-1 | Comiskey Park I (13-17) | 27-34 | Won 3 |
| » Starters: Russ VanAtta vs Jack Knott | Fifth | 11½ out |
| Friday, July 8 |
| » Lost to Tigers (36-36), 7-5 | Tiger Stadium (0-2) | 27-35 | |
| » Starters: Monty Stratton vs Vern Kennedy | Fifth | 12 out |
| » Defeated Tigers (36-37), 5-3 | Tiger Stadium (1-2) | 28-35 | |
| » Starters: Thornton Lee vs Boots Poffenberger | Fifth | 12 out |
| Saturday, July 9 |
| » Lost to Tigers (37-37), 4-0 | Tiger Stadium (1-3) | 28-36 | |
| » Starters: John Whitehead vs Elden Auker | Fifth | 13 out |
| Sunday, July 10 |
| » Defeated Tigers (37-38), 5-4 | Tiger Stadium (2-3) | 29-36 | |
| » Starters: Ted Lyons vs Harry Eisenstat | Sixth | 13 out |
| Tuesday, July 12 |
| » Defeated Athletics (27-43), 8-6 | Shibe Park (4-3) | 30-36 | Won 2 |
| » Starters: Monty Stratton vs Lynn Nelson | Sixth | 12 out |
| Wednesday, July 13 |
| » Lost to Athletics (28-43), 5-2 | Shibe Park (4-4) | 30-37 | |
| » Starters: Jack Knott vs George Caster | Sixth | 12½ out |
| Future White Sox Don Pavletich is born in Milwaukee, WI. |
| Thursday, July 14 |
| » Defeated Athletics (28-44), 9-8 | Shibe Park (5-4) | 31-37 | |
| » Starters: John Whitehead vs Bud Thomas | Sixth | 12½ out |
| Friday, July 15 |
| » Defeated Senators (41-39), 11-3 | Griffith Stadium (1-5) | 32-37 | Won 2 |
| » Starters: Thornton Lee vs Wes Ferrell | Sixth | 12½ out |
| Saturday, July 16 |
| » Lost to Senators (42-39), 3-2 | Griffith Stadium (1-6) | 32-38 | |
| » Starters: Ted Lyons vs Monte Weaver | Sixth | 13½ out |
| Sunday, July 17 |
| » Defeated Senators (42-40), 12-1 | Griffith Stadium (2-6) | 33-38 | |
| » Starters: Monty Stratton vs Harry Kelley | Sixth | 13½ out |
| Future White Sox Deron Johnson is born in San Diego, CA. |
| Sunday, July 24 |
| » Lost to Yankees (50-28), 2-0 | Yankee Stadium (3-3) | 33-39 | |
| » Starters: Thornton Lee vs Lefty Gomez | Fifth | 13 out |
| » Defeated Yankees (50-29), 8-3 | Yankee Stadium (4-3) | 34-39 | |
| » Starters: Monty Stratton vs Red Ruffing | Fifth | 13 out |
| Tuesday, July 26 |
| » Defeated Red Sox (48-33), 9-1 | Comiskey Park I (14-17) | 35-39 | Won 2 |
| » Starters: Fritz Ostermueller vs Ted Lyons | Fifth | 13½ out |
| Thursday, July 28 |
| » Lost to Red Sox (49-33), 13-8 | Comiskey Park I (14-18) | 35-40 | |
| » Starters: Jack Wilson vs Jack Knott | Sixth | 14½ out |
| » Lost to Red Sox (50-33), 8-5 | Comiskey Park I (14-19) | 35-41 | Lost 2 |
| » Starters: Archie McKain vs John Whitehead | Sixth | 14½ out |
| Friday, July 29 |
| » Lost to Yankees (54-30), 4-3 | Comiskey Park I (14-20) | 35-42 | Lost 3 |
| » Starters: Lefty Gomez vs Thornton Lee | Sixth | 15½ out |
| Saturday, July 30 |
| » Lost to Yankees (55-30), 9-6 | Comiskey Park I (14-21) | 35-43 | Lost 4 |
| » Starters: Red Ruffing vs Monty Stratton | Sixth | 16½ out |
| Sunday, July 31 |
| » Lost to Yankees (56-30), 5-1 | Comiskey Park I (14-22) | 35-44 | Lost 5 |
| » Starters: Monte Pearson vs Ted Lyons | Sixth | 18½ out |
| » Lost to Yankees (57-30), 7-3 | Comiskey Park I (14-23) | 35-45 | Lost 6 |
| » Starters: Spud Chandler vs Jack Knott | Sixth | 18½ out |
| Tuesday, August 2 |
| » Defeated Athletics (30-54), 8-4 | Comiskey Park I (15-23) | 36-45 | |
| » Starters: Al Williams vs Monty Stratton | Sixth | 17½ out |
| Wednesday, August 3 |
| » Lost to Athletics (31-54), 14-2 | Comiskey Park I (15-24) | 36-46 | |
| » Starters: Bud Thomas vs John Whitehead | Sixth | 19 out |
| » Lost to Athletics (32-54), 13-5 | Comiskey Park I (15-25) | 36-47 | Lost 2 |
| » Starters: George Caster vs Johnny Rigney | Sixth | 19 out |
| Thursday, August 4 |
| » Defeated Athletics (32-55), 8-2 | Comiskey Park I (16-25) | 37-47 | |
| » Starters: Nels Potter vs Thornton Lee | Sixth | 18½ out |
| » Defeated Athletics (32-56), 7-3 | Comiskey Park I (17-25) | 38-47 | Won 2 |
| » Starters: Buck Ross vs Jack Knott | Sixth | 18½ out |
| Saturday, August 6 |
| » Lost to Senators (50-48), 7-1 | Comiskey Park I (17-26) | 38-48 | |
| » Starters: Dutch Leonard vs Ted Lyons | Sixth | 20 out |
| Sunday, August 7 |
| » Defeated Senators (50-49), 14-5 | Comiskey Park I (18-26) | 39-48 | |
| » Starters: Wes Ferrell vs Monty Stratton | Sixth | 20½ out |
| » Lost to Senators (51-49), 12-5 | Comiskey Park I (18-27) | 39-49 | |
| » Starters: Monte Weaver vs Thornton Lee | Sixth | 20½ out |
| Tuesday, August 9 |
| » Lost to Tigers (49-51), 4-1 | Comiskey Park I (18-28) | 39-50 | Lost 2 |
| » Starters: Tommy Bridges vs Jack Knott | Sixth | 20½ out |
| Wednesday, August 10 |
| » Defeated Tigers (49-52), 8-7 | Comiskey Park I (19-28) | 40-50 | |
| » Starters: Elden Auker vs Thornton Lee | Sixth | 20½ out |
| Thursday, August 11 |
| » Defeated Tigers (49-53), 13-1 | Comiskey Park I (20-28) | 41-50 | Won 2 |
| » Starters: Roxie Lawson vs Monty Stratton | Sixth | 20½ out |
| Friday, August 12 |
| » Lost to Indians (58-38), 12-9 | Comiskey Park I (20-29) | 41-51 | |
| » Starters: Mel Harder vs Ted Lyons | Sixth | 20½ out |
| » Defeated Indians (58-39), 6-5 | Comiskey Park I (21-29) | 42-51 | |
| » Starters: Denny Galehouse vs Johnny Rigney | Sixth | 20½ out |
| Saturday, August 13 |
| » Lost to Indians (59-39), 13-4 | Comiskey Park I (21-30) | 42-52 | |
| » Starters: Bob Feller vs Jack Knott | Sixth | 21 out |
| » Defeated Indians (59-40), 2-1 | Comiskey Park I (22-30) | 43-52 | |
| » Starters: Johnny Allen vs Thornton Lee | Sixth | 21 out |
| Sunday, August 14 |
| » Lost to Indians (60-40), 6-4 | Comiskey Park I (22-31) | 43-53 | |
| » Starters: Earl Whitehill vs Monty Stratton | Sixth | 22½ out |
| Wednesday, August 17 |
| » Lost to Tigers (50-55), 4-3 | Tiger Stadium (2-4) | 43-54 | Lost 2 |
| » Starters: Ted Lyons vs Tommy Bridges | Sixth | 24½ out |
| » Lost to Tigers (51-55), 3-2 | Tiger Stadium (2-5) | 43-55 | Lost 3 |
| » Starters: Jack Knott vs Al Benton | Sixth | 24½ out |
| Thursday, August 18 |
| » Lost to Tigers (52-55), 5-1 | Tiger Stadium (2-6) | 43-56 | Lost 4 |
| » Starters: John Whitehead vs George Gill | Sixth | 25 out |
| Friday, August 19 |
| » Defeated Indians (61-43), 7-2 | League Park II (2-2) | 44-56 | |
| » Starters: Thornton Lee vs Earl Whitehill | Sixth | 25 out |
| Saturday, August 20 |
| » Lost to Indians (62-43), 8-2 | League Park II (2-3) | 44-57 | |
| » Starters: Monty Stratton vs Mel Harder | Sixth | 26 out |
| Sunday, August 21 |
| » Defeated Indians (62-44), 4-3 | Cleveland Stadium (1-0) | 45-57 | |
| » Starters: Ted Lyons vs Johnny Allen | Sixth | 27 out |
| » Lost to Indians (63-44), 3-2 | Cleveland Stadium (1-1) | 45-58 | |
| » Starters: Jack Knott vs Willis Hudlin | Sixth | 27 out |
| Monday, August 22 |
| » Defeated Indians (63-45), 4-2 | League Park II (3-3) | 46-58 | |
| » Starters: John Whitehead vs Bob Feller | Sixth | 26½ out |
| Tuesday, August 23 |
| » Defeated Yankees (75-35), 11-3 | Yankee Stadium (5-3) | 47-58 | Won 2 |
| » Starters: Thornton Lee vs Wes Ferrell | Sixth | 26½ out |
| » Lost to Yankees (76-35), 3-1 | Yankee Stadium (5-4) | 47-59 | |
| » Starters: Johnny Rigney vs Bump Hadley | Sixth | 26½ out |
| Wednesday, August 24 |
| » Defeated Yankees (76-36), 8-5 | Yankee Stadium (6-4) | 48-59 | |
| » Starters: Monty Stratton vs Spud Chandler | Sixth | 26½ out |
| » Lost to Yankees (77-36), 11-1 | Yankee Stadium (6-5) | 48-60 | |
| » Starters: Frank Gabler vs Monte Pearson | Sixth | 26½ out |
| Thursday, August 25 |
| » Lost to Red Sox (64-46), 1-0 | Fenway Park (2-3) | 48-61 | Lost 2 |
| » Starters: Jack Knott vs Jack Wilson | Sixth | 28½ out |
| » Lost to Red Sox (65-46), 9-5 | Fenway Park (2-4) | 48-62 | Lost 3 |
| » Starters: John Whitehead vs Joe Heving | Sixth | 28½ out |
| Friday, August 26 |
| » Defeated Red Sox (65-47), 12-2 | Fenway Park (3-4) | 49-62 | |
| » Starters: Ted Lyons vs Jim Bagby | Sixth | 28½ out |
| » Lost to Red Sox (66-47), 9-8 | Fenway Park (3-5) | 49-63 | |
| » Starters: Johnny Rigney vs Dick Midkiff | Sixth | 28½ out |
| Saturday, August 27 |
| » Lost to Red Sox (67-47), 19-6 | Fenway Park (3-6) | 49-64 | Lost 2 |
| » Starters: Frank Gabler vs Fritz Ostermueller | Sixth | 30½ out |
| » Lost to Red Sox (68-47), 1-0 | Fenway Park (3-7) | 49-65 | Lost 3 |
| » Starters: Thornton Lee vs Bill Harris | Sixth | 30½ out |
| Sunday, August 28 |
| » Lost to Athletics (43-76), 5-4 | Shibe Park (5-5) | 49-66 | Lost 4 |
| » Starters: John Whitehead vs Buck Ross | Sixth | 32 out |
| » Lost to Athletics (44-76), 7-2 | Shibe Park (5-6) | 49-67 | Lost 5 |
| » Starters: Jack Knott vs Bud Thomas | Sixth | 32 out |
| Tuesday, August 30 |
| » Defeated Senators (61-61), 3-2 | Griffith Stadium (3-6) | 50-67 | |
| » Starters: Johnny Rigney vs Pete Appleton | Sixth | 32½ out |
| Wednesday, August 31 |
| » Defeated Senators (61-62), 7-0 | Griffith Stadium (4-6) | 51-67 | Won 2 |
| » Starters: John Whitehead vs Dutch Leonard | Sixth | 31½ out |
| Thursday, September 1 |
| » Defeated Senators (61-63), 11-6 | Griffith Stadium (5-6) | 52-67 | Won 3 |
| » Starters: Thornton Lee vs Harry Kelley | Sixth | 30½ out |
| Saturday, September 3 |
| » Lost to Tigers (64-60), 11-4 | Comiskey Park I (22-32) | 52-68 | |
| » Starters: Tommy Bridges vs Jack Knott | Sixth | 31 out |
| Sunday, September 4 |
| » Defeated Tigers (64-61), 2-1 | Comiskey Park I (23-32) | 53-68 | |
| » Starters: Al Benton vs Johnny Rigney | Sixth | 31 out |
| » Major-league debuts: Mike Tresh (White Sox) |
| Monday, September 5 |
| » Lost to Indians (72-53), 6-4 | Comiskey Park I (23-33) | 53-69 | |
| » Starters: Al Milnar vs Thornton Lee | Sixth | 33 out |
| » Lost to Indians (73-53), 4-2 | Comiskey Park I (23-34) | 53-70 | Lost 2 |
| » Starters: Willis Hudlin vs John Whitehead | Sixth | 33 out |
| Tuesday, September 6 |
| » Defeated Browns (45-81), 8-2 | Comiskey Park I (24-34) | 54-70 | |
| » Starters: Ed Cole vs Monty Stratton | Fifth | 32½ out |
| Sunday, September 11 |
| » Lost to Tigers (68-64), 10-1 | Tiger Stadium (2-7) | 54-71 | |
| » Starters: Ted Lyons vs George Gill | Sixth | 34 out |
| » Lost to Tigers (69-64), 5-3 | Tiger Stadium (2-8) | 54-72 | Lost 2 |
| » Starters: Johnny Rigney vs Slick Coffman | Sixth | 34 out |
| Monday, September 12 |
| » Lost to Tigers (70-64), 4-3 | Tiger Stadium (2-9) | 54-73 | Lost 3 |
| » Starters: Jack Knott vs Al Benton | Sixth | 34½ out |
| Tuesday, September 13 |
| » Lost to Senators (67-69), 7-1 | Comiskey Park I (24-35) | 54-74 | Lost 4 |
| » Starters: Ken Chase vs Monty Stratton | Sixth | 35 out |
| » Defeated Senators (67-70), 3-2 | Comiskey Park I (25-35) | 55-74 | |
| » Starters: Pete Appleton vs Thornton Lee | Sixth | 35 out |
| Thursday, September 15 |
| » Defeated Athletics (49-87), 5-4 | Comiskey Park I (26-35) | 56-74 | Won 2 |
| » Starters: Buck Ross vs John Whitehead | Sixth | 34½ out |
| » Lost to Athletics (50-87), 1-0 | Comiskey Park I (26-36) | 56-75 | |
| » Starters: George Caster vs Johnny Rigney | Sixth | 34½ out |
| Saturday, September 17 |
| » Defeated Athletics (50-88), 8-4 | Comiskey Park I (27-36) | 57-75 | |
| » Starters: Randy Gumpert vs Ted Lyons | Sixth | 33½ out |
| » Defeated Athletics (50-89), 7-4 | Comiskey Park I (28-36) | 58-75 | Won 2 |
| » Starters: Jim Reninger vs Jack Knott | Sixth | 33½ out |
| Sunday, September 18 |
| » Major-league debuts: Chuck Workman (Indians) |
| Tuesday, September 20 |
| » Defeated Yankees (94-48), 5-4 | Comiskey Park I (29-36) | 59-75 | Won 3 |
| » Starters: Bump Hadley vs Monty Stratton | Sixth | 31 out |
| Wednesday, September 21 |
| » Defeated Yankees (94-49), 5-2 | Comiskey Park I (30-36) | 60-75 | Won 4 |
| » Starters: Lefty Gomez vs Thornton Lee | Sixth | 30 out |
| Thursday, September 22 |
| » Lost to Yankees (95-49), 7-4 | Comiskey Park I (30-37) | 60-76 | |
| » Starters: Steve Sundra vs Johnny Rigney | Sixth | 31 out |
| Saturday, September 24 |
| » Lost to Browns (51-89), 8-7 | Sportsman's Park III (5-3) | 60-77 | Lost 2 |
| » Starters: Ted Lyons vs Lefty Mills | Sixth | 30½ out |
| » Defeated Browns (51-90), 3-2 | Sportsman's Park III (6-3) | 61-77 | |
| » Starters: Jack Knott vs Ed Cole | Sixth | 30½ out |
| » Major-league debuts: Joe Grace (Browns) |
| Sunday, September 25 |
| » Lost to Browns (52-90), 7-2 | Sportsman's Park III (6-4) | 61-78 | |
| » Starters: John Whitehead vs Bobo Newsom | Sixth | 31 out |
| » Lost to Browns (53-90), 8-4 | Sportsman's Park III (6-5) | 61-79 | Lost 2 |
| » Starters: Harry Boyles vs Emil Bildilli | Sixth | 31 out |
| Tuesday, September 27 |
| » Lost to Indians (84-63), 6-1 | League Park II (3-4) | 61-80 | Lost 3 |
| » Starters: Monty Stratton vs Bob Feller | Sixth | 32½ out |
| Wednesday, September 28 |
| » Defeated Indians (84-64), 14-11 | League Park II (4-4) | 62-80 | |
| » Starters: Thornton Lee vs Earl Whitehill | Sixth | 31½ out |
| » Major-league debuts: Oscar Grimes (Indians) |
| Thursday, September 29 |
| » Lost to Indians (85-64), 9-8 | League Park II (4-5) | 62-81 | |
| » Starters: Johnny Rigney vs Willis Hudlin | Sixth | 32½ out |
| Friday, September 30 |
| » Defeated Browns (53-95), 7-5 | Comiskey Park I (31-37) | 63-81 | |
| » Starters: Bill Trotter vs Ted Lyons | Sixth | 32 out |
| » Tied Browns, 3-3 | Comiskey Park I (31-37) | 63-81 | |
| » Starters: Harry Kimberlin vs Jack Knott | Sixth | 32 out |
| Saturday, October 1 |
| » Defeated Browns (53-96), 6-3 | Comiskey Park I (32-37) | 64-81 | Won 2 |
| » Starters: Jim Walkup vs John Whitehead | Sixth | 31½ out |
| » Lost to Browns (54-96), 4-0 | Comiskey Park I (32-38) | 64-82 | |
| » Starters: Russ VanAtta vs Harry Boyles | Sixth | 31½ out |
| Sunday, October 2 |
| » Lost to Browns (55-96), 4-3 | Comiskey Park I (32-39) | 64-83 | Lost 2 |
| » Starters: Bobo Newsom vs Thornton Lee | Sixth | 32 out |
| » Defeated Browns (55-97), 3-0 | Comiskey Park I (33-39) | 65-83 | |
| » Starters: Emil Bildilli vs Johnny Rigney | Sixth | 32 out |
| Tuesday, October 18 |
| Future White Sox Bobby Knoop is born in Sioux City, IA. |
| Monday, November 7 |
| Future White Sox Jim Kaat is born in Zeeland, MI. |
| Friday, November 11 |
| Former White Sox Fred Hartman dies in McKeesport, PA at the age of 71. |
| Sunday, December 25 |
| Future White Sox Jack Hamilton is born in Burlington, IA. |
Game information provided by Retrosheet (www.retrosheet.org) |
