| Friday, January 7 |
| Future Indian Fred Whitfield is born in Vandiver, AL. |
| Monday, January 31 |
| Former Indian Charlie Chech dies in Los Angeles, CA at the age of 60. |
| Wednesday, February 2 |
| Future Indian Max Alvis is born in Jasper, TX. |
| Sunday, March 6 |
| Former Indian Rube Lutzke dies in Granville, WI at the age of 41. |
| Thursday, March 17 |
| Future Indian Jimmie Hall is born in Mount Holly, NC. |
| Monday, April 18 |
| » Major-league debuts: Taffy Wright (Senators) |
| Tuesday, April 19 |
| » Lost to Browns (1-0), 6-2 | League Park II (0-1) | 0-1 | |
| » Starters: Bobo Newsom vs Johnny Allen | Fifth | 1½ out |
| Wednesday, April 20 |
| » Defeated Browns (1-1), 9-0 | League Park II (1-1) | 1-1 | |
| » Starters: Jim Weaver vs Bob Feller | Fourth | 1½ out |
| Thursday, April 21 |
| » Defeated Browns (1-2), 4-3 | League Park II (2-1) | 2-1 | Won 2 |
| » Starters: Vito Tamulis vs Earl Whitehill | Third | 1 out |
| Friday, April 22 |
| » Defeated Tigers (1-3), 4-3 | Tiger Stadium (1-0) | 3-1 | Won 3 |
| » Starters: Mel Harder vs Tommy Bridges | First | -- |
| Saturday, April 23 |
| » Defeated Tigers (1-4), 6-3 | Tiger Stadium (2-0) | 4-1 | Won 4 |
| » Starters: Johnny Allen vs Jake Wade | First | -- |
| Sunday, April 24 |
| » Defeated Tigers (1-5), 9-4 | Tiger Stadium (3-0) | 5-1 | Won 5 |
| » Starters: Bob Feller vs George Gill | First | -- |
| Tuesday, April 26 |
| » Defeated White Sox (3-4), 10-6 | Comiskey Park I (1-0) | 6-1 | Won 6 |
| » Starters: Earl Whitehill vs Sugar Cain | First | -- |
| Wednesday, April 27 |
| » Lost to White Sox (4-4), 6-3 | Comiskey Park I (1-1) | 6-2 | |
| » Starters: Mel Harder vs Thornton Lee | First | -- |
| Thursday, April 28 |
| » Defeated Browns (4-6), 11-6 | Sportsman's Park III (1-0) | 7-2 | |
| » Starters: Johnny Allen vs Vito Tamulis | First | -- |
| Friday, April 29 |
| » Defeated Browns (4-7), 3-2 | Sportsman's Park III (2-0) | 8-2 | Won 2 |
| » Starters: Bob Feller vs Russ VanAtta | First | -- |
| Saturday, April 30 |
| » Lost to Tigers (5-6), 5-3 | League Park II (2-2) | 8-3 | |
| » Starters: Vern Kennedy vs Willis Hudlin | First | -- |
| Sunday, May 1 |
| » Defeated Tigers (5-7), 4-3 | Cleveland Stadium (1-0) | 9-3 | |
| » Starters: Elden Auker vs Mel Harder | First | -- |
| Monday, May 2 |
| » Defeated Tigers (5-8), 11-3 | League Park II (3-2) | 10-3 | Won 2 |
| » Starters: Jake Wade vs Johnny Allen | First | -- |
| Tuesday, May 3 |
| » Defeated Senators (8-7), 10-9 | Griffith Stadium (1-0) | 11-3 | Won 3 |
| » Starters: Al Milnar vs Wes Ferrell | First | -- |
| Wednesday, May 4 |
| » Lost to Senators (9-7), 1-0 | Griffith Stadium (1-1) | 11-4 | |
| » Starters: Bob Feller vs Dutch Leonard | First | -- |
| Thursday, May 5 |
| » Lost to Senators (10-7), 8-6 | Griffith Stadium (1-2) | 11-5 | Lost 2 |
| » Starters: Mel Harder vs Chief Hogsett | First | -- |
| » Major-league debuts: Hank Helf (Indians) |
| Friday, May 6 |
| » Defeated Athletics (5-11), 4-1 | Shibe Park (1-0) | 12-5 | |
| » Starters: Johnny Allen vs George Caster | First | -- |
| Saturday, May 7 |
| » Defeated Athletics (5-12), 4-2 | Shibe Park (2-0) | 13-5 | Won 2 |
| » Starters: Willis Hudlin vs Buck Ross | First | -- |
| Sunday, May 8 |
| » Lost to Red Sox (11-8), 5-0 | Fenway Park (0-1) | 13-6 | |
| » Starters: Bob Feller vs Jack Wilson | First | -- |
| Monday, May 9 |
| » Lost to Red Sox (12-8), 15-3 | Fenway Park (0-2) | 13-7 | Lost 2 |
| » Starters: Denny Galehouse vs Jim Bagby | Second | ½ out |
| Wednesday, May 11 |
| » Lost to Yankees (14-7), 4-1 | Yankee Stadium (0-1) | 13-8 | Lost 3 |
| » Starters: Mel Harder vs Spud Chandler | Third | 1 out |
| Thursday, May 12 |
| » Defeated Yankees (14-8), 3-2 | Yankee Stadium (1-1) | 14-8 | |
| » Starters: Bob Feller vs Lefty Gomez | Second | 1 out |
| Friday, May 13 |
| » Lost to White Sox (8-11), 7-6 | League Park II (3-3) | 14-9 | |
| » Starters: Thornton Lee vs Willis Hudlin | Third | 1 out |
| Monday, May 16 |
| » Defeated Athletics (7-14), 4-3 | League Park II (4-3) | 15-9 | |
| » Starters: Bud Thomas vs Johnny Allen | Second | 1 out |
| Tuesday, May 17 |
| » Defeated Athletics (7-15), 5-1 | League Park II (5-3) | 16-9 | Won 2 |
| » Starters: George Caster vs Earl Whitehill | Second | ½ out |
| Wednesday, May 18 |
| » Defeated Athletics (7-16), 7-2 | League Park II (6-3) | 17-9 | Won 3 |
| » Starters: Al Williams vs Bob Feller | Second | 1 out |
| Thursday, May 19 |
| » Defeated Senators (17-13), 15-3 | League Park II (7-3) | 18-9 | Won 4 |
| » Starters: Jimmie DeShong vs Willis Hudlin | First | -- |
| Friday, May 20 |
| » Defeated Senators (17-14), 6-3 | League Park II (8-3) | 19-9 | Won 5 |
| » Starters: Dutch Leonard vs Johnny Allen | First | -- |
| Saturday, May 21 |
| » Lost to Senators (18-14), 5-4 | League Park II (8-4) | 19-10 | |
| » Starters: Ken Chase vs Earl Whitehill | First | -- |
| Sunday, May 22 |
| » Defeated Yankees (16-10), 8-3 | Cleveland Stadium (2-0) | 20-10 | |
| » Starters: Monte Pearson vs Bob Feller | First | -- |
| Tuesday, May 24 |
| » Defeated Yankees (16-11), 9-5 | League Park II (9-4) | 21-10 | Won 2 |
| » Starters: Lefty Gomez vs Johnny Allen | First | -- |
| Wednesday, May 25 |
| » Defeated Red Sox (18-12), 6-4 | League Park II (10-4) | 22-10 | Won 3 |
| » Starters: Fritz Ostermueller vs Mel Harder | First | -- |
| Thursday, May 26 |
| » Lost to Red Sox (19-12), 8-4 | League Park II (10-5) | 22-11 | |
| » Starters: Jack Wilson vs Denny Galehouse | First | -- |
| Sunday, May 29 |
| » Lost to Browns (10-22), 8-6 | Sportsman's Park III (2-1) | 22-12 | Lost 2 |
| » Starters: Earl Whitehill vs Bobo Newsom | First | -- |
| Monday, May 30 |
| » Defeated White Sox (12-17), 5-2 | League Park II (11-5) | 23-12 | |
| » Starters: Ted Lyons vs Bob Feller | First | -- |
| » Defeated White Sox (12-18), 8-1 | League Park II (12-5) | 24-12 | Won 2 |
| » Starters: Thornton Lee vs Johnny Allen | First | -- |
| Wednesday, June 1 |
| » Lost to Athletics (15-20), 9-5 | Shibe Park (2-1) | 24-13 | |
| » Starters: Mel Harder vs Lynn Nelson | First | -- |
| Thursday, June 2 |
| » Defeated Athletics (15-21), 10-5 | Shibe Park (3-1) | 25-13 | |
| » Starters: Earl Whitehill vs Eddie Smith | First | -- |
| Friday, June 3 |
| » Defeated Athletics (15-22), 10-5 | Shibe Park (4-1) | 26-13 | Won 2 |
| » Starters: Johnny Allen vs Bud Thomas | First | -- |
| Saturday, June 4 |
| » Defeated Senators (25-19), 11-4 | Griffith Stadium (2-2) | 27-13 | Won 3 |
| » Starters: Bob Feller vs Chief Hogsett | First | -- |
| Sunday, June 5 |
| » Defeated Senators (25-20), 5-4 | Griffith Stadium (3-2) | 28-13 | Won 4 |
| » Starters: Mel Harder vs Pete Appleton | First | -- |
| Monday, June 6 |
| » Lost to Senators (26-20), 5-4 | Griffith Stadium (3-3) | 28-14 | |
| » Starters: Earl Whitehill vs Ken Chase | First | -- |
| Tuesday, June 7 |
| » Defeated Red Sox (23-19), 7-5 | Fenway Park (1-2) | 29-14 | |
| » Starters: Johnny Allen vs Jim Bagby | First | -- |
| Wednesday, June 8 |
| » Lost to Red Sox (24-19), 7-6 | Fenway Park (1-3) | 29-15 | |
| » Starters: Bob Feller vs Lee Rogers | First | -- |
| Thursday, June 9 |
| » Lost to Red Sox (25-19), 8-0 | Fenway Park (1-4) | 29-16 | Lost 2 |
| » Starters: Mel Harder vs Lefty Grove | First | -- |
| Friday, June 10 |
| » Lost to Yankees (26-19), 8-2 | Yankee Stadium (1-2) | 29-17 | Lost 3 |
| » Starters: Earl Whitehill vs Lefty Gomez | First | -- |
| Sunday, June 12 |
| » Lost to Yankees (27-19), 7-6 | Yankee Stadium (1-3) | 29-18 | Lost 4 |
| » Starters: Johnny Allen vs Red Ruffing | First | -- |
| Tuesday, June 14 |
| » Lost to Senators (28-25), 7-6 | League Park II (12-6) | 29-19 | Lost 5 |
| » Starters: Jimmie DeShong vs Johnny Humphries | First | -- |
| Wednesday, June 15 |
| » Defeated Senators (28-26), 6-4 | League Park II (13-6) | 30-19 | |
| » Starters: Ken Chase vs Earl Whitehill | First | -- |
| Thursday, June 16 |
| » Defeated Senators (28-27), 4-1 | League Park II (14-6) | 31-19 | Won 2 |
| » Starters: Joe Krakauskas vs Bob Feller | First | -- |
| Friday, June 17 |
| » Defeated Athletics (23-28), 8-1 | League Park II (15-6) | 32-19 | Won 3 |
| » Starters: Buck Ross vs Johnny Allen | First | -- |
| Saturday, June 18 |
| » Lost to Athletics (24-28), 8-4 | League Park II (15-7) | 32-20 | |
| » Starters: Lynn Nelson vs Willis Hudlin | First | -- |
| Sunday, June 19 |
| » Defeated Athletics (24-29), 5-4 | Cleveland Stadium (3-0) | 33-20 | |
| » Starters: George Caster vs Earl Whitehill | First | -- |
| Tuesday, June 21 |
| » Defeated Yankees (31-22), 10-5 | League Park II (16-7) | 34-20 | Won 2 |
| » Starters: Red Ruffing vs Bob Feller | First | -- |
| Wednesday, June 22 |
| » Defeated Yankees (31-23), 3-1 | League Park II (17-7) | 35-20 | Won 3 |
| » Starters: Lefty Gomez vs Mel Harder | First | -- |
| » Defeated Yankees (31-24), 7-1 | League Park II (18-7) | 36-20 | Won 4 |
| » Starters: Monte Pearson vs Johnny Allen | First | -- |
| Thursday, June 23 |
| » Lost to Yankees (32-24), 8-6 | League Park II (18-8) | 36-21 | |
| » Starters: Bump Hadley vs Denny Galehouse | First | -- |
| Friday, June 24 |
| » Defeated Red Sox (33-26), 7-6 | League Park II (19-8) | 37-21 | |
| » Starters: Jim Bagby vs Johnny Humphries | First | -- |
| Monday, June 27 |
| » Defeated Red Sox (33-27), 7-3 | League Park II (20-8) | 38-21 | Won 2 |
| » Starters: Lefty Grove vs Bob Feller | First | -- |
| Tuesday, June 28 |
| » Defeated Tigers (32-32), 5-4 | League Park II (21-8) | 39-21 | Won 3 |
| » Starters: Tommy Bridges vs Johnny Allen | First | -- |
| Wednesday, June 29 |
| » Lost to Tigers (33-32), 4-3 | League Park II (21-9) | 39-22 | |
| » Starters: Elden Auker vs Mel Harder | First | -- |
| Thursday, June 30 |
| » Defeated Tigers (33-33), 10-9 | League Park II (22-9) | 40-22 | |
| » Starters: Vern Kennedy vs Bob Feller | First | -- |
| Sunday, July 3 |
| » Defeated White Sox (24-34), 2-1 | Comiskey Park I (2-1) | 41-22 | Won 2 |
| » Starters: Johnny Allen vs Ted Lyons | First | -- |
| » Lost to White Sox (25-34), 3-0 | Comiskey Park I (2-2) | 41-23 | |
| » Starters: Johnny Humphries vs Thornton Lee | First | -- |
| Monday, July 4 |
| » Lost to Tigers (34-36), 7-3 | Tiger Stadium (3-1) | 41-24 | Lost 2 |
| » Starters: Bob Feller vs Elden Auker | First | -- |
| » Lost to Tigers (35-36), 5-2 | Tiger Stadium (3-2) | 41-25 | Lost 3 |
| » Starters: Mel Harder vs Harry Eisenstat | First | -- |
| Friday, July 8 |
| » Defeated Browns (22-45), 8-7 | League Park II (23-9) | 42-25 | |
| » Starters: Oral Hildebrand vs Earl Whitehill | First | -- |
| Saturday, July 9 |
| » Defeated Browns (22-46), 5-4 | League Park II (24-9) | 43-25 | Won 2 |
| » Starters: Lefty Mills vs Bob Feller | First | -- |
| Sunday, July 10 |
| » Defeated Browns (22-47), 8-7 | Cleveland Stadium (4-0) | 44-25 | Won 3 |
| » Starters: Bobo Newsom vs Johnny Allen | First | -- |
| Tuesday, July 12 |
| » Lost to Senators (40-37), 9-8 | Griffith Stadium (3-4) | 44-26 | |
| » Starters: Denny Galehouse vs Ken Chase | First | -- |
| Wednesday, July 13 |
| » Lost to Senators (41-37), 4-3 | Griffith Stadium (3-5) | 44-27 | Lost 2 |
| » Starters: Bob Feller vs Harry Kelley | Second | ½ out |
| Thursday, July 14 |
| » Defeated Senators (41-38), 5-1 | Griffith Stadium (4-5) | 45-27 | |
| » Starters: Mel Harder vs Dutch Leonard | Second | ½ out |
| Friday, July 15 |
| » Lost to Athletics (29-44), 5-4 | Shibe Park (4-2) | 45-28 | |
| » Starters: Willis Hudlin vs Buck Ross | Second | 1½ out |
| Saturday, July 16 |
| » Defeated Athletics (29-45), 9-8 | Shibe Park (5-2) | 46-28 | |
| » Starters: Earl Whitehill vs Lynn Nelson | Second | 1½ out |
| Sunday, July 17 |
| » Defeated Athletics (29-46), 7-6 | Shibe Park (6-2) | 47-28 | Won 2 |
| » Starters: Bob Feller vs George Caster | Second | 1½ out |
| Tuesday, July 19 |
| » Defeated Yankees (49-28), 5-3 | Yankee Stadium (2-3) | 48-28 | Won 3 |
| » Starters: Mel Harder vs Bump Hadley | Second | ½ out |
| Friday, July 22 |
| » Lost to Red Sox (47-31), 7-4 | Fenway Park (1-5) | 48-29 | |
| » Starters: Bob Feller vs Jack Wilson | Second | 1 out |
| Monday, July 25 |
| » Lost to Red Sox (48-31), 4-0 | Fenway Park (1-6) | 48-30 | Lost 2 |
| » Starters: Johnny Allen vs Emerson Dickman | Second | 1 out |
| » Defeated Red Sox (48-32), 3-0 | Fenway Park (2-6) | 49-30 | |
| » Starters: Mel Harder vs Jim Bagby | Second | 1 out |
| Tuesday, July 26 |
| » Defeated Athletics (29-49), 4-2 | League Park II (25-9) | 50-30 | Won 2 |
| » Starters: George Caster vs Bob Feller | Second | 1½ out |
| Wednesday, July 27 |
| » Defeated Athletics (29-50), 12-11 | League Park II (26-9) | 51-30 | Won 3 |
| » Starters: Buck Ross vs Willis Hudlin | Second | 1½ out |
| Friday, July 29 |
| » Defeated Senators (46-46), 12-4 | League Park II (27-9) | 52-30 | Won 4 |
| » Starters: Chief Hogsett vs Johnny Allen | Second | 1 out |
| Saturday, July 30 |
| » Defeated Senators (46-47), 8-5 | League Park II (28-9) | 53-30 | Won 5 |
| » Starters: Ken Chase vs Mel Harder | Second | 1 out |
| Monday, August 1 |
| » Lost to Senators (47-47), 11-8 | League Park II (28-10) | 53-31 | |
| » Starters: Dutch Leonard vs Bob Feller | Second | 2½ out |
| Tuesday, August 2 |
| » Defeated Red Sox (51-36), 7-4 | League Park II (29-10) | 54-31 | |
| » Starters: Emerson Dickman vs Denny Galehouse | Second | 1½ out |
| » Major-league debuts: Jim Tabor (Red Sox) |
| Wednesday, August 3 |
| » Lost to Red Sox (52-36), 4-3 | League Park II (29-11) | 54-32 | |
| » Starters: Jack Wilson vs Mel Harder | Second | 2 out |
| » Defeated Red Sox (52-37), 8-6 | League Park II (30-11) | 55-32 | |
| » Starters: Bill Harris vs Earl Whitehill | Second | 2 out |
| Friday, August 5 |
| » Lost to Yankees (60-31), 6-1 | League Park II (30-12) | 55-33 | |
| » Starters: Bump Hadley vs Bob Feller | Second | 3½ out |
| Saturday, August 6 |
| » Lost to Yankees (61-31), 7-3 | League Park II (30-13) | 55-34 | Lost 2 |
| » Starters: Lefty Gomez vs Johnny Allen | Second | 4½ out |
| Sunday, August 7 |
| » Lost to Yankees (62-31), 7-0 | Cleveland Stadium (4-1) | 55-35 | Lost 3 |
| » Starters: Red Ruffing vs Mel Harder | Second | 5½ out |
| Tuesday, August 9 |
| » Lost to Browns (32-63), 4-3 | Sportsman's Park III (2-2) | 55-36 | Lost 4 |
| » Starters: Bob Feller vs Lefty Mills | Second | 5 out |
| » Defeated Browns (32-64), 8-1 | Sportsman's Park III (3-2) | 56-36 | |
| » Starters: Earl Whitehill vs Russ VanAtta | Second | 5 out |
| Wednesday, August 10 |
| » Defeated Browns (32-65), 9-6 | Sportsman's Park III (4-2) | 57-36 | Won 2 |
| » Starters: Johnny Allen vs Fred Johnson | Second | 5 out |
| Thursday, August 11 |
| » Lost to Browns (33-65), 8-7 | Sportsman's Park III (4-3) | 57-37 | |
| » Starters: Al Milnar vs Bobo Newsom | Second | 6½ out |
| » Lost to Browns (34-65), 8-2 | Sportsman's Park III (4-4) | 57-38 | Lost 2 |
| » Starters: Willis Hudlin vs Les Tietje | Second | 6½ out |
| Future Indian Vada Pinson is born in Memphis, TN. |
| Friday, August 12 |
| » Defeated White Sox (41-51), 12-9 | Comiskey Park I (3-2) | 58-38 | |
| » Starters: Mel Harder vs Ted Lyons | Second | 6½ out |
| » Lost to White Sox (42-51), 6-5 | Comiskey Park I (3-3) | 58-39 | |
| » Starters: Denny Galehouse vs Johnny Rigney | Second | 6½ out |
| Saturday, August 13 |
| » Defeated White Sox (42-52), 13-4 | Comiskey Park I (4-3) | 59-39 | |
| » Starters: Bob Feller vs Jack Knott | Second | 7 out |
| » Lost to White Sox (43-52), 2-1 | Comiskey Park I (4-4) | 59-40 | |
| » Starters: Johnny Allen vs Thornton Lee | Second | 7 out |
| Sunday, August 14 |
| » Defeated White Sox (43-53), 6-4 | Comiskey Park I (5-4) | 60-40 | |
| » Starters: Earl Whitehill vs Monty Stratton | Second | 7½ out |
| Tuesday, August 16 |
| » Defeated Browns (36-66), 9-6 | League Park II (31-13) | 61-40 | Won 2 |
| » Starters: Les Tietje vs Mel Harder | Second | 8 out |
| Wednesday, August 17 |
| » Lost to Browns (37-66), 10-7 | League Park II (31-14) | 61-41 | |
| » Starters: Fred Johnson vs Johnny Allen | Second | 8½ out |
| Thursday, August 18 |
| » Lost to Browns (38-66), 9-1 | League Park II (31-15) | 61-42 | Lost 2 |
| » Starters: Bobo Newsom vs Bob Feller | Second | 9 out |
| Friday, August 19 |
| » Lost to White Sox (44-56), 7-2 | League Park II (31-16) | 61-43 | Lost 3 |
| » Starters: Thornton Lee vs Earl Whitehill | Second | 10 out |
| Saturday, August 20 |
| » Defeated White Sox (44-57), 8-2 | League Park II (32-16) | 62-43 | |
| » Starters: Monty Stratton vs Mel Harder | Second | 10 out |
| Sunday, August 21 |
| » Lost to White Sox (45-57), 4-3 | Cleveland Stadium (4-2) | 62-44 | |
| » Starters: Ted Lyons vs Johnny Allen | Second | 11 out |
| » Defeated White Sox (45-58), 3-2 | Cleveland Stadium (5-2) | 63-44 | |
| » Starters: Jack Knott vs Willis Hudlin | Second | 11 out |
| Monday, August 22 |
| » Lost to White Sox (46-58), 4-2 | League Park II (32-17) | 63-45 | |
| » Starters: John Whitehead vs Bob Feller | Second | 11½ out |
| Tuesday, August 23 |
| » Lost to Red Sox (62-45), 13-3 | Fenway Park (2-7) | 63-46 | Lost 2 |
| » Starters: Johnny Humphries vs Fritz Ostermueller | Third | 12½ out |
| » Lost to Red Sox (63-45), 14-12 | Fenway Park (2-8) | 63-47 | Lost 3 |
| » Starters: Denny Galehouse vs Jim Bagby | Third | 12½ out |
| Wednesday, August 24 |
| » Defeated Red Sox (63-46), 5-3 | Fenway Park (3-8) | 64-47 | |
| » Starters: Mel Harder vs Bill Harris | Third | 12 out |
| Thursday, August 25 |
| » Lost to Yankees (78-36), 5-2 | Yankee Stadium (2-4) | 64-48 | |
| » Starters: Earl Whitehill vs Lefty Gomez | Third | 14 out |
| » Lost to Yankees (79-36), 15-3 | Yankee Stadium (2-5) | 64-49 | Lost 2 |
| » Starters: Johnny Allen vs Red Ruffing | Third | 14 out |
| Friday, August 26 |
| » Lost to Yankees (80-36), 15-9 | Yankee Stadium (2-6) | 64-50 | Lost 3 |
| » Starters: Bob Feller vs Wes Ferrell | Third | 14 out |
| » Defeated Yankees (80-37), 8-5 | Yankee Stadium (3-6) | 65-50 | |
| » Starters: Willis Hudlin vs Steve Sundra | Third | 14 out |
| Saturday, August 27 |
| » Lost to Yankees (81-37), 8-7 | Yankee Stadium (3-7) | 65-51 | |
| » Starters: Al Milnar vs Bump Hadley | Third | 16 out |
| » Lost to Yankees (82-37), 13-0 | Yankee Stadium (3-8) | 65-52 | Lost 2 |
| » Starters: Johnny Humphries vs Monte Pearson | Third | 16 out |
| Sunday, August 28 |
| » Defeated Senators (60-60), 6-5 | Griffith Stadium (5-5) | 66-52 | |
| » Starters: Mel Harder vs Monte Weaver | Third | 16 out |
| Monday, August 29 |
| » Lost to Senators (61-60), 6-4 | Griffith Stadium (5-6) | 66-53 | |
| » Starters: Earl Whitehill vs Ken Chase | Third | 17 out |
| Tuesday, August 30 |
| » Defeated Athletics (44-77), 10-8 | Shibe Park (7-2) | 67-53 | |
| » Starters: Johnny Allen vs Nels Potter | Third | 17 out |
| Wednesday, August 31 |
| » Defeated Athletics (44-78), 8-6 | Shibe Park (8-2) | 68-53 | Won 2 |
| » Starters: Willis Hudlin vs George Caster | Third | 16 out |
| Thursday, September 1 |
| » Defeated Athletics (44-79), 11-4 | Shibe Park (9-2) | 69-53 | Won 3 |
| » Starters: Bob Feller vs Buck Ross | Third | 15 out |
| Saturday, September 3 |
| » Defeated Browns (44-78), 10-2 | Sportsman's Park III (5-4) | 70-53 | Won 4 |
| » Starters: Mel Harder vs Oral Hildebrand | Third | 14½ out |
| Sunday, September 4 |
| » Defeated Browns (44-79), 11-3 | Sportsman's Park III (6-4) | 71-53 | Won 5 |
| » Starters: Johnny Allen vs Bill Cox | Third | 14½ out |
| » Tied Browns, 1-1 | Sportsman's Park III (6-4) | 71-53 | |
| » Starters: Earl Whitehill vs Russ VanAtta | Third | 14½ out |
| Monday, September 5 |
| » Defeated White Sox (53-69), 6-4 | Comiskey Park I (6-4) | 72-53 | Won 6 |
| » Starters: Al Milnar vs Thornton Lee | Third | 14½ out |
| » Defeated White Sox (53-70), 4-2 | Comiskey Park I (7-4) | 73-53 | Won 7 |
| » Starters: Willis Hudlin vs John Whitehead | Third | 14½ out |
| Tuesday, September 6 |
| » Defeated Tigers (65-63), 6-0 | Tiger Stadium (4-2) | 74-53 | Won 8 |
| » Starters: Bob Feller vs Harry Eisenstat | Second | 14 out |
| Wednesday, September 7 |
| » Defeated Tigers (65-64), 1-0 | Tiger Stadium (5-2) | 75-53 | Won 9 |
| » Starters: Mel Harder vs Slick Coffman | Second | 13 out |
| Thursday, September 8 |
| » Lost to Tigers (66-64), 4-1 | League Park II (32-18) | 75-54 | |
| » Starters: Al Benton vs Earl Whitehill | Second | 14 out |
| Friday, September 9 |
| » Lost to Tigers (67-64), 11-5 | League Park II (32-19) | 75-55 | Lost 2 |
| » Starters: Tommy Bridges vs Willis Hudlin | Second | 15 out |
| » Major-league debuts: Lou Boudreau and Ray Mack (Indians) |
| Saturday, September 10 |
| » Lost to Browns (46-81), 4-2 | League Park II (32-20) | 75-56 | Lost 3 |
| » Starters: Bobo Newsom vs Al Milnar | Second | 16 out |
| Sunday, September 11 |
| » Defeated Browns (46-82), 6-2 | Cleveland Stadium (6-2) | 76-56 | |
| » Starters: Lefty Mills vs Bob Feller | Third | 15½ out |
| » Lost to Browns (47-82), 4-3 | Cleveland Stadium (6-3) | 76-57 | |
| » Starters: Russ VanAtta vs Mel Harder | Third | 15½ out |
| Tuesday, September 13 |
| » Lost to Yankees (93-42), 7-1 | League Park II (32-21) | 76-58 | Lost 2 |
| » Starters: Red Ruffing vs Denny Galehouse | Third | 16½ out |
| Future Indian Bob Heffner is born in Allentown, PA. |
| Wednesday, September 14 |
| » Major-league debuts: George Archie and Benny McCoy (Tigers) |
| Thursday, September 15 |
| » Defeated Red Sox (77-58), 3-2 | League Park II (33-21) | 77-58 | |
| » Starters: Jack Wilson vs Mel Harder | Third | 16 out |
| » Lost to Red Sox (78-58), 3-2 | League Park II (33-22) | 77-59 | |
| » Starters: Fritz Ostermueller vs Bob Feller | Third | 16 out |
| Future Indian Gaylord Perry is born in Williamston, NC. |
| Friday, September 16 |
| » Lost to Red Sox (79-58), 2-1 | League Park II (33-23) | 77-60 | Lost 2 |
| » Starters: Archie McKain vs Denny Galehouse | Third | 17 out |
| Saturday, September 17 |
| » Defeated Red Sox (79-59), 5-4 | League Park II (34-23) | 78-60 | |
| » Starters: Jack Wilson vs Earl Whitehill | Third | 16 out |
| Sunday, September 18 |
| » Defeated Athletics (50-90), 7-3 | Cleveland Stadium (7-3) | 79-60 | Won 2 |
| » Starters: Lynn Nelson vs Willis Hudlin | Third | 15 out |
| » Lost to Athletics (51-90), 14-3 | Cleveland Stadium (7-4) | 79-61 | |
| » Starters: Bud Thomas vs Bob Feller | Third | 15 out |
| » Major-league debuts: Chuck Workman (Indians) |
| Monday, September 19 |
| » Defeated Athletics (51-91), 4-3 | League Park II (35-23) | 80-61 | |
| » Starters: George Caster vs Mel Harder | Third | 14 out |
| Tuesday, September 20 |
| » Defeated Senators (71-72), 9-1 | League Park II (36-23) | 81-61 | Won 2 |
| » Starters: Dutch Leonard vs Denny Galehouse | Third | 13 out |
| Friday, September 23 |
| » Defeated Tigers (76-68), 8-1 | Tiger Stadium (6-2) | 82-61 | Won 3 |
| » Starters: Bob Feller vs George Gill | Third | 12 out |
| » Defeated Tigers (76-69), 6-5 | Tiger Stadium (7-2) | 83-61 | Won 4 |
| » Starters: Earl Whitehill vs Al Benton | Third | 12 out |
| Saturday, September 24 |
| » Lost to Tigers (77-69), 7-6 | Tiger Stadium (7-3) | 83-62 | |
| » Starters: Mel Harder vs Tommy Bridges | Third | 12 out |
| Future Indian George Banks is born in Pacolet Mills, SC. |
| Sunday, September 25 |
| » Lost to Tigers (78-69), 7-5 | Tiger Stadium (7-4) | 83-63 | Lost 2 |
| » Starters: Denny Galehouse vs Boots Poffenberger | Third | 12 out |
| Tuesday, September 27 |
| » Defeated White Sox (61-80), 6-1 | League Park II (37-23) | 84-63 | |
| » Starters: Monty Stratton vs Bob Feller | Third | 12½ out |
| Wednesday, September 28 |
| » Lost to White Sox (62-80), 14-11 | League Park II (37-24) | 84-64 | |
| » Starters: Thornton Lee vs Earl Whitehill | Third | 12½ out |
| » Major-league debuts: Oscar Grimes (Indians) |
| Thursday, September 29 |
| » Defeated White Sox (62-81), 9-8 | League Park II (38-24) | 85-64 | |
| » Starters: Johnny Rigney vs Willis Hudlin | Third | 12½ out |
| Saturday, October 1 |
| » Defeated Tigers (82-70), 5-0 | League Park II (39-24) | 86-64 | Won 2 |
| » Starters: Boots Poffenberger vs Denny Galehouse | Third | 11½ out |
| Sunday, October 2 |
| » Lost to Tigers (83-70), 4-1 | Cleveland Stadium (7-5) | 86-65 | |
| » Starters: Harry Eisenstat vs Bob Feller | Third | 13 out |
| » Lost to Tigers (84-70), 10-8 | Cleveland Stadium (7-6) | 86-66 | Lost 2 |
| » Starters: Bob Harris vs Johnny Humphries | Third | 13 out |
| Future Indian Mike de la Hoz is born. |
| Monday, November 14 |
| Former Indian Les Nunamaker dies in Hastings, NE at the age of 50. |
| Saturday, December 17 |
| Future Indian Leo Cardenas is born in Matanzas, Cuba. |
| Monday, December 19 |
| Former Indian Art Griggs dies in Los Angeles, CA at the age of 56. |
| Sunday, December 25 |
| Future Indian Jack Hamilton is born in Burlington, IA. |
Game information provided by Retrosheet (www.retrosheet.org) |
