| Thursday, January 14 |
| Future Red Sox Sonny Siebert is born in St. Marys, MO. |
| Friday, January 15 |
| Former Red Sox Eddie Foster dies in Washington, DC at the age of 50. |
| Sunday, February 7 |
| Future Red Sox Juan Pizarro is born in Santurce, P.R. |
| Wednesday, March 24 |
| Future Red Sox Bob Tillman is born in Nashville, TN. |
| Friday, April 2 |
| Future Red Sox Dick Radatz is born in Detroit, MI. |
| Sunday, April 4 |
| Future Red Sox Gary Geiger is born in Sand Ridge, IL. |
| Tuesday, April 20 |
| » Defeated Athletics (1-1), 11-5 | Shibe Park (1-0) | 1-0 | |
| » Starters: Wes Ferrell vs Harry Kelley | First | -- |
| » Major-league debuts: Bobby Doerr (Red Sox) |
| Wednesday, April 21 |
| Future Red Sox Gary Peters is born in Grove City, PA. |
| Friday, April 23 |
| » Major-league debuts: Ben Huffman and Bill Trotter (Browns) |
| Saturday, April 24 |
| » Lost to Yankees (1-1), 6-5 | Fenway Park (0-1) | 1-1 | |
| » Starters: Monte Pearson vs Lefty Grove | Third | 1 out |
| Sunday, April 25 |
| » Lost to Yankees (2-1), 9-3 | Fenway Park (0-2) | 1-2 | Lost 2 |
| » Starters: Bump Hadley vs Wes Ferrell | Fifth | 1½ out |
| » Major-league debuts: Archie McKain (Red Sox) |
| Monday, April 26 |
| » Defeated Senators (1-4), 12-5 | Fenway Park (1-2) | 2-2 | |
| » Starters: Jimmie DeShong vs Johnny Marcum | Fourth | 1 out |
| Friday, April 30 |
| » Defeated Athletics (3-3), 15-5 | Fenway Park (2-2) | 3-2 | Won 2 |
| » Starters: Bud Thomas vs Wes Ferrell | Third | 1 out |
| Saturday, May 1 |
| » Lost to Yankees (6-2), 3-2 | Yankee Stadium (0-1) | 3-3 | |
| » Starters: Rube Walberg vs Bump Hadley | Fourth | 2 out |
| Sunday, May 2 |
| » Defeated Yankees (6-3), 5-4 | Yankee Stadium (1-1) | 4-3 | |
| » Starters: Johnny Marcum vs Johnny Broaca | Third | 1½ out |
| Tuesday, May 4 |
| » Defeated Browns (3-6), 11-6 | Sportsman's Park III (1-0) | 5-3 | Won 2 |
| » Starters: Wes Ferrell vs Julio Bonetti | Second | 1 out |
| Wednesday, May 5 |
| » Major-league debuts: Chet Laabs (Tigers) |
| Thursday, May 6 |
| » Defeated Browns (3-7), 2-1 | Sportsman's Park III (2-0) | 6-3 | Won 3 |
| » Starters: Johnny Marcum vs Les Tietje | Second | 1½ out |
| Friday, May 7 |
| » Defeated White Sox (3-9), 5-3 | Comiskey Park I (1-0) | 7-3 | Won 4 |
| » Starters: Lefty Grove vs Vern Kennedy | First | -- |
| Saturday, May 8 |
| » Lost to White Sox (4-9), 6-5 | Comiskey Park I (1-1) | 7-4 | |
| » Starters: Wes Ferrell vs Bill Dietrich | Second | 1½ out |
| Sunday, May 9 |
| » Lost to Indians (8-5), 3-1 | Cleveland Stadium (0-1) | 7-5 | Lost 2 |
| » Starters: Rube Walberg vs Willis Hudlin | Third | ½ out |
| Monday, May 10 |
| » Lost to Indians (9-5), 6-5 | League Park II (0-1) | 7-6 | Lost 3 |
| » Starters: Johnny Marcum vs Earl Whitehill | Third | 1½ out |
| Tuesday, May 11 |
| » Defeated Indians (9-6), 11-4 | League Park II (1-1) | 8-6 | |
| » Starters: Jack Wilson vs Lloyd Brown | Third | 1½ out |
| Thursday, May 13 |
| » Lost to Tigers (10-8), 4-0 | Tiger Stadium (0-1) | 8-7 | |
| » Starters: Wes Ferrell vs George Gill | Fourth | 2 out |
| Saturday, May 15 |
| » Lost to Senators (8-12), 5-4 | Griffith Stadium (0-1) | 8-8 | Lost 2 |
| » Starters: Lefty Grove vs Bobo Newsom | Fourth | 2 out |
| Sunday, May 16 |
| » Defeated Senators (8-13), 6-5 | Griffith Stadium (1-1) | 9-8 | |
| » Starters: Johnny Marcum vs Monte Weaver | Third | 1½ out |
| Monday, May 17 |
| » Lost to Senators (9-13), 4-3 | Griffith Stadium (1-2) | 9-9 | |
| » Starters: Wes Ferrell vs Jimmie DeShong | Fifth | 2 out |
| Tuesday, May 18 |
| » Lost to Indians (10-8), 7-4 | Fenway Park (2-3) | 9-10 | Lost 2 |
| » Starters: Mel Harder vs Rube Walberg | Fifth | 3 out |
| Thursday, May 20 |
| » Lost to Indians (11-8), 16-5 | Fenway Park (2-4) | 9-11 | Lost 3 |
| » Starters: Johnny Allen vs Johnny Marcum | Seventh | 2½ out |
| Friday, May 21 |
| » Lost to Tigers (14-11), 4-2 | Fenway Park (2-5) | 9-12 | Lost 4 |
| » Starters: Slick Coffman vs Lefty Grove | Seventh | 3½ out |
| » Major-league debuts: Slick Coffman (Tigers) |
| Saturday, May 22 |
| » Defeated Tigers (14-12), 11-9 | Fenway Park (3-5) | 10-12 | |
| » Starters: George Gill vs Wes Ferrell | Sixth | 3½ out |
| Sunday, May 23 |
| » Lost to White Sox (11-14), 6-4 | Fenway Park (3-6) | 10-13 | |
| » Starters: John Whitehead vs Johnny Marcum | Seventh | 4½ out |
| Monday, May 24 |
| » Defeated White Sox (11-15), 9-5 | Fenway Park (4-6) | 11-13 | |
| » Starters: Johnny Rigney vs Rube Walberg | Fifth | 4½ out |
| Tuesday, May 25 |
| » Defeated Browns (9-18), 4-2 | Fenway Park (5-6) | 12-13 | Won 2 |
| » Starters: Chief Hogsett vs Lefty Grove | Fifth | 4½ out |
| Wednesday, May 26 |
| » Defeated Browns (9-19), 11-9 | Fenway Park (6-6) | 13-13 | Won 3 |
| » Starters: Julio Bonetti vs Wes Ferrell | Fifth | 4½ out |
| Friday, May 28 |
| » Defeated Senators (14-19), 7-0 | Fenway Park (7-6) | 14-13 | Won 4 |
| » Starters: Bobo Newsom vs Johnny Marcum | Fifth | 3½ out |
| Saturday, May 29 |
| » Defeated Senators (14-20), 4-2 | Fenway Park (8-6) | 15-13 | Won 5 |
| » Starters: Jimmie DeShong vs Archie McKain | Fourth | 4 out |
| Sunday, May 30 |
| » Lost to Senators (15-20), 11-4 | Fenway Park (8-7) | 15-14 | |
| » Starters: Pete Appleton vs Fritz Ostermueller | Fourth | 5 out |
| Monday, May 31 |
| » Lost to Yankees (23-11), 4-3 | Fenway Park (8-8) | 15-15 | Lost 2 |
| » Starters: Bump Hadley vs Lefty Grove | Fourth | 5 out |
| » Defeated Yankees (23-12), 8-2 | Fenway Park (9-8) | 16-15 | |
| » Starters: Johnny Broaca vs Rube Walberg | Fourth | 5 out |
| Thursday, June 3 |
| » Lost to White Sox (20-17), 11-4 | Comiskey Park I (1-2) | 16-16 | |
| » Starters: Wes Ferrell vs Vern Kennedy | Fifth | 5½ out |
| Saturday, June 5 |
| » Defeated Browns (11-27), 11-4 | Sportsman's Park III (3-0) | 17-16 | |
| » Starters: Lefty Grove vs Chief Hogsett | Fifth | 5 out |
| Sunday, June 6 |
| » Defeated Browns (11-28), 6-5 | Sportsman's Park III (4-0) | 18-16 | Won 2 |
| » Starters: Johnny Marcum vs Tommy Thomas | Fifth | 4½ out |
| » Lost to Browns (12-28), 3-2 | Sportsman's Park III (4-1) | 18-17 | |
| » Starters: Rube Walberg vs Julio Bonetti | Fifth | 4½ out |
| Monday, June 7 |
| » Lost to Browns (13-28), 9-6 | Sportsman's Park III (4-2) | 18-18 | Lost 2 |
| » Starters: Wes Ferrell vs Oral Hildebrand | Fifth | 4½ out |
| Tuesday, June 8 |
| » Defeated Indians (23-17), 10-8 | League Park II (2-1) | 19-18 | |
| » Starters: Archie McKain vs Johnny Allen | Fourth | 3½ out |
| Wednesday, June 9 |
| » Lost to Indians (24-17), 12-6 | League Park II (2-2) | 19-19 | |
| » Starters: Fritz Ostermueller vs Mel Harder | Fourth | 4 out |
| Friday, June 11 |
| » Lost to Tigers (27-20), 6-5 | Tiger Stadium (0-2) | 19-20 | Lost 2 |
| » Starters: Lefty Grove vs George Gill | Fifth | 5½ out |
| » Major-league debuts: Boots Poffenberger (Tigers) |
| Saturday, June 12 |
| » Lost to Tigers (28-20), 3-2 | Tiger Stadium (0-3) | 19-21 | Lost 3 |
| » Starters: Rube Walberg vs Roxie Lawson | Fifth | 5 out |
| » Defeated Tigers (28-21), 5-4 | Tiger Stadium (1-3) | 20-21 | |
| » Starters: Bobo Newsom vs Jake Wade | Fifth | 5 out |
| Sunday, June 13 |
| » Lost to Tigers (29-21), 3-1 | Tiger Stadium (1-4) | 20-22 | |
| » Starters: Jack Wilson vs Elden Auker | Fifth | 6 out |
| Tuesday, June 15 |
| » Defeated White Sox (28-20), 5-1 | Fenway Park (10-8) | 21-22 | |
| » Starters: Vern Kennedy vs Lefty Grove | Fifth | 6 out |
| Wednesday, June 16 |
| » Defeated White Sox (28-21), 3-2 | Fenway Park (11-8) | 22-22 | Won 2 |
| » Starters: John Whitehead vs Bobo Newsom | Fifth | 6 out |
| Thursday, June 17 |
| » Defeated White Sox (28-22), 5-2 | Fenway Park (12-8) | 23-22 | Won 3 |
| » Starters: Bill Dietrich vs Jack Wilson | Fifth | 5½ out |
| » Defeated White Sox (28-23), 3-2 | Fenway Park (13-8) | 24-22 | Won 4 |
| » Starters: Monty Stratton vs Rube Walberg | Fifth | 5½ out |
| Friday, June 18 |
| » Defeated Indians (26-23), 5-4 | Fenway Park (14-8) | 25-22 | Won 5 |
| » Starters: Johnny Allen vs Fritz Ostermueller | Fourth | 5 out |
| Sunday, June 20 |
| » Defeated Indians (26-24), 5-2 | Fenway Park (15-8) | 26-22 | Won 6 |
| » Starters: Willis Hudlin vs Lefty Grove | Fourth | 5½ out |
| » Lost to Indians (27-24), 8-7 | Fenway Park (15-9) | 26-23 | |
| » Starters: Mel Harder vs Bobo Newsom | Fourth | 5½ out |
| Wednesday, June 23 |
| » Defeated Tigers (33-23), 6-5 | Fenway Park (16-9) | 27-23 | |
| » Starters: Roxie Lawson vs Jack Wilson | Fourth | 5 out |
| Thursday, June 24 |
| » Defeated Tigers (33-24), 9-0 | Fenway Park (17-9) | 28-23 | Won 2 |
| » Starters: Elden Auker vs Lefty Grove | Fourth | 5 out |
| Friday, June 25 |
| » Defeated Browns (19-35), 4-2 | Fenway Park (18-9) | 29-23 | Won 3 |
| » Starters: Julio Bonetti vs Bobo Newsom | Third | 5 out |
| Saturday, June 26 |
| » Lost to Browns (20-35), 7-1 | Fenway Park (18-10) | 29-24 | |
| » Starters: Jim Walkup vs Johnny Marcum | Third | 5 out |
| Sunday, June 27 |
| » Defeated Browns (20-36), 8-0 | Fenway Park (19-10) | 30-24 | |
| » Starters: Oral Hildebrand vs Jack Wilson | Fourth | 4½ out |
| » Defeated Browns (20-37), 11-7 | Fenway Park (20-10) | 31-24 | Won 2 |
| » Starters: Jack Knott vs Rube Walberg | Fourth | 4½ out |
| Tuesday, June 29 |
| » Tied Senators, 2-2 | Griffith Stadium (1-2) | 31-24 | |
| » Starters: Lefty Grove vs Monte Weaver | Third | 5 out |
| Wednesday, June 30 |
| » Lost to Senators (27-33), 6-4 | Griffith Stadium (1-3) | 31-25 | |
| » Starters: Bobo Newsom vs Wes Ferrell | Fourth | 6 out |
| Thursday, July 1 |
| » Lost to Senators (28-33), 3-2 | Griffith Stadium (1-4) | 31-26 | Lost 2 |
| » Starters: Jack Wilson vs Jimmie DeShong | Fourth | 7 out |
| Friday, July 2 |
| » Defeated Athletics (20-40), 8-4 | Fenway Park (21-10) | 32-26 | |
| » Starters: George Caster vs Johnny Marcum | Fourth | 6 out |
| Saturday, July 3 |
| » Defeated Athletics (20-41), 8-3 | Fenway Park (22-10) | 33-26 | Won 2 |
| » Starters: Harry Kelley vs Fritz Ostermueller | Fourth | 6 out |
| Sunday, July 4 |
| » Defeated Athletics (20-42), 7-6 | Fenway Park (23-10) | 34-26 | Won 3 |
| » Starters: Herman Fink vs Lefty Grove | Third | 5½ out |
| » Defeated Athletics (20-43), 4-2 | Fenway Park (24-10) | 35-26 | Won 4 |
| » Starters: Bud Thomas vs Bobo Newsom | Third | 5½ out |
| Monday, July 5 |
| » Lost to Yankees (43-22), 15-0 | Yankee Stadium (1-2) | 35-27 | |
| » Starters: Jack Wilson vs Red Ruffing | Fourth | 7½ out |
| » Lost to Yankees (44-22), 8-4 | Yankee Stadium (1-3) | 35-28 | Lost 2 |
| » Starters: Rube Walberg vs Spud Chandler | Fourth | 7½ out |
| Wednesday, July 7 |
| Future Red Sox George Smith is born in St. Petersburg, FL. |
| Friday, July 9 |
| » Defeated Athletics (20-45), 12-11 | Shibe Park (2-0) | 36-28 | |
| » Starters: Bobo Newsom vs George Turbeville | Fourth | 7½ out |
| Saturday, July 10 |
| » Defeated Athletics (20-46), 9-2 | Shibe Park (3-0) | 37-28 | Won 2 |
| » Starters: Lefty Grove vs George Caster | Fourth | 7 out |
| » Defeated Athletics (20-47), 5-2 | Shibe Park (4-0) | 38-28 | Won 3 |
| » Starters: Johnny Marcum vs Herman Fink | Fourth | 7 out |
| Sunday, July 11 |
| » Defeated Athletics (20-48), 9-4 | Shibe Park (5-0) | 39-28 | Won 4 |
| » Starters: Jack Wilson vs Bud Thomas | Fourth | 6½ out |
| » Defeated Athletics (20-49), 8-2 | Shibe Park (6-0) | 40-28 | Won 5 |
| » Starters: Archie McKain vs Eddie Smith | Fourth | 6½ out |
| Wednesday, July 14 |
| » Defeated Browns (22-48), 15-6 | Sportsman's Park III (5-2) | 41-28 | Won 6 |
| » Starters: Bobo Newsom vs Jim Walkup | Second | 6½ out |
| Thursday, July 15 |
| » Lost to Browns (23-48), 5-3 | Sportsman's Park III (5-3) | 41-29 | |
| » Starters: Johnny Marcum vs Oral Hildebrand | Second | 7½ out |
| Friday, July 16 |
| » Defeated Browns (23-49), 6-4 | Sportsman's Park III (6-3) | 42-29 | |
| » Starters: Jack Wilson vs Jack Knott | Second | 6½ out |
| Saturday, July 17 |
| » Lost to White Sox (46-32), 4-0 | Comiskey Park I (1-3) | 42-30 | |
| » Starters: Lefty Grove vs John Whitehead | Fourth | 7½ out |
| Sunday, July 18 |
| » Lost to White Sox (47-32), 6-5 | Comiskey Park I (1-4) | 42-31 | Lost 2 |
| » Starters: Bobo Newsom vs Ted Lyons | Fourth | 9 out |
| » Lost to White Sox (48-32), 1-0 | Comiskey Park I (1-5) | 42-32 | Lost 3 |
| » Starters: Archie McKain vs Monty Stratton | Fourth | 9 out |
| Monday, July 19 |
| » Lost to White Sox (49-32), 6-4 | Comiskey Park I (1-6) | 42-33 | Lost 4 |
| » Starters: Johnny Marcum vs Vern Kennedy | Fourth | 10 out |
| Tuesday, July 20 |
| » Lost to Tigers (47-31), 10-9 | Tiger Stadium (1-5) | 42-34 | Lost 5 |
| » Starters: Jack Wilson vs Elden Auker | Fourth | 11½ out |
| Wednesday, July 21 |
| » Defeated Tigers (47-32), 10-3 | Tiger Stadium (2-5) | 43-34 | |
| » Starters: Lefty Grove vs Tommy Bridges | Fourth | 11½ out |
| Thursday, July 22 |
| » Lost to Tigers (48-32), 17-4 | Tiger Stadium (2-6) | 43-35 | |
| » Starters: Bobo Newsom vs Jake Wade | Fourth | 11½ out |
| Friday, July 23 |
| » Defeated Indians (40-39), 6-2 | League Park II (3-2) | 44-35 | |
| » Starters: Archie McKain vs Willis Hudlin | Fourth | 10½ out |
| Saturday, July 24 |
| » Lost to Indians (41-39), 6-5 | League Park II (3-3) | 44-36 | |
| » Starters: Bobo Newsom vs Bob Feller | Fourth | 10½ out |
| Sunday, July 25 |
| » Defeated Indians (41-40), 4-1 | Cleveland Stadium (1-1) | 45-36 | |
| » Starters: Lefty Grove vs Earl Whitehill | Fourth | 10 out |
| Tuesday, July 27 |
| » Lost to Browns (28-57), 8-5 | Fenway Park (24-11) | 45-37 | |
| » Starters: Lou Koupal vs Johnny Marcum | Fourth | 11 out |
| Wednesday, July 28 |
| » Defeated Browns (28-58), 5-4 | Fenway Park (25-11) | 46-37 | |
| » Starters: Oral Hildebrand vs Bobo Newsom | Fourth | 10 out |
| Thursday, July 29 |
| » Defeated Browns (28-59), 5-3 | Fenway Park (26-11) | 47-37 | Won 2 |
| » Starters: Bill Trotter vs Archie McKain | Fourth | 10 out |
| Friday, July 30 |
| » Defeated Tigers (51-36), 6-5 | Fenway Park (27-11) | 48-37 | Won 3 |
| » Starters: Tommy Bridges vs Lefty Grove | Fourth | 10 out |
| Saturday, July 31 |
| » Defeated Tigers (51-37), 12-1 | Fenway Park (28-11) | 49-37 | Won 4 |
| » Starters: Jake Wade vs Fritz Ostermueller | Fourth | 9 out |
| Sunday, August 1 |
| » Defeated Tigers (51-38), 11-4 | Fenway Park (29-11) | 50-37 | Won 5 |
| » Starters: Roxie Lawson vs Jack Wilson | Third | 9 out |
| » Tied Tigers, 2-2 | Fenway Park (29-11) | 50-37 | |
| » Starters: Elden Auker vs Bobo Newsom | Third | 9 out |
| Tuesday, August 3 |
| » Defeated Indians (43-45), 13-2 | Fenway Park (30-11) | 51-37 | Won 6 |
| » Starters: Mel Harder vs Lefty Grove | Third | 9½ out |
| Wednesday, August 4 |
| » Defeated Indians (43-46), 8-6 | Fenway Park (31-11) | 52-37 | Won 7 |
| » Starters: Denny Galehouse vs Archie McKain | Third | 9 out |
| » Defeated Indians (43-47), 6-5 | Fenway Park (32-11) | 53-37 | Won 8 |
| » Starters: Whit Wyatt vs Fritz Ostermueller | Third | 9 out |
| Thursday, August 5 |
| » Defeated Indians (43-48), 5-4 | Fenway Park (33-11) | 54-37 | Won 9 |
| » Starters: Willis Hudlin vs Bobo Newsom | Second | 9 out |
| Friday, August 6 |
| » Defeated White Sox (57-41), 7-3 | Fenway Park (34-11) | 55-37 | Won 10 |
| » Starters: Bill Dietrich vs Jack Wilson | Second | 9 out |
| Saturday, August 7 |
| » Defeated White Sox (57-42), 5-4 | Fenway Park (35-11) | 56-37 | Won 11 |
| » Starters: Ted Lyons vs Lefty Grove | Second | 9 out |
| Sunday, August 8 |
| » Defeated White Sox (57-43), 7-6 | Fenway Park (36-11) | 57-37 | Won 12 |
| » Starters: Vern Kennedy vs Archie McKain | Second | 9½ out |
| » Lost to White Sox (58-43), 13-0 | Fenway Park (36-12) | 57-38 | |
| » Starters: John Whitehead vs Fritz Ostermueller | Second | 9½ out |
| Wednesday, August 11 |
| » Lost to Yankees (68-29), 8-5 | Fenway Park (36-13) | 57-39 | Lost 2 |
| » Starters: Red Ruffing vs Lefty Grove | Second | 11½ out |
| » Lost to Yankees (69-29), 10-4 | Fenway Park (36-14) | 57-40 | Lost 3 |
| » Starters: Pat Malone vs Bobo Newsom | Second | 11½ out |
| Thursday, August 12 |
| » Defeated Yankees (69-30), 16-10 | Fenway Park (37-14) | 58-40 | |
| » Starters: Monte Pearson vs Johnny Marcum | Second | 11½ out |
| » Lost to Yankees (70-30), 5-3 | Fenway Park (37-15) | 58-41 | |
| » Starters: Bump Hadley vs Archie McKain | Second | 11½ out |
| Friday, August 13 |
| » Lost to Senators (46-53), 3-0 | Griffith Stadium (1-5) | 58-42 | Lost 2 |
| » Starters: Johnny Marcum vs Pete Appleton | Second | 11½ out |
| Saturday, August 14 |
| » Lost to Senators (47-53), 8-3 | Griffith Stadium (1-6) | 58-43 | Lost 3 |
| » Starters: Bobo Newsom vs Ed Linke | Third | 11½ out |
| Sunday, August 15 |
| » Lost to Senators (48-53), 8-3 | Griffith Stadium (1-7) | 58-44 | Lost 4 |
| » Starters: Lefty Grove vs Wes Ferrell | Fourth | 12 out |
| » Lost to Senators (49-53), 9-3 | Griffith Stadium (1-8) | 58-45 | Lost 5 |
| » Starters: Archie McKain vs Monte Weaver | Fourth | 12 out |
| Monday, August 16 |
| Former Red Sox Bunk Congalton dies in Cleveland, OH at the age of 63. |
| Tuesday, August 17 |
| » Defeated Athletics (32-70), 6-1 | Shibe Park (7-0) | 59-45 | |
| » Starters: Jack Wilson vs Buck Ross | Fourth | 12½ out |
| Future Red Sox Diego Segui is born in Holguin, Cuba. |
| Wednesday, August 18 |
| » Lost to Athletics (33-70), 4-2 | Shibe Park (7-1) | 59-46 | |
| » Starters: Bobo Newsom vs George Caster | Fourth | 13½ out |
| Thursday, August 19 |
| » Defeated Athletics (33-71), 5-4 | Shibe Park (8-1) | 60-46 | |
| » Starters: Johnny Marcum vs Harry Kelley | Fourth | 13½ out |
| Friday, August 20 |
| » Lost to Senators (50-57), 3-1 | Fenway Park (37-16) | 60-47 | |
| » Starters: Monte Weaver vs Lefty Grove | Fourth | 14½ out |
| Tuesday, August 24 |
| » Lost to Indians (53-55), 4-3 | League Park II (3-4) | 60-48 | Lost 2 |
| » Starters: Lefty Grove vs Johnny Allen | Fourth | 14½ out |
| Wednesday, August 25 |
| » Lost to Indians (54-55), 8-1 | League Park II (3-5) | 60-49 | Lost 3 |
| » Starters: Bobo Newsom vs Bob Feller | Fourth | 15 out |
| » Defeated Indians (54-56), 7-2 | League Park II (4-5) | 61-49 | |
| » Starters: Archie McKain vs Willis Hudlin | Fourth | 15 out |
| Thursday, August 26 |
| » Lost to Tigers (68-46), 6-5 | Tiger Stadium (2-7) | 61-50 | |
| » Starters: Johnny Marcum vs Roxie Lawson | Fourth | 16 out |
| Friday, August 27 |
| » Defeated Tigers (68-47), 8-5 | Tiger Stadium (3-7) | 62-50 | |
| » Starters: Jack Wilson vs Jake Wade | Fourth | 16 out |
| Saturday, August 28 |
| » Defeated Tigers (68-48), 3-0 | Tiger Stadium (4-7) | 63-50 | Won 2 |
| » Starters: Lefty Grove vs Boots Poffenberger | Fourth | 15 out |
| Sunday, August 29 |
| » Defeated Browns (36-80), 2-0 | Sportsman's Park III (7-3) | 64-50 | Won 3 |
| » Starters: Bobo Newsom vs Bill Trotter | Fourth | 15½ out |
| » Lost to Browns (37-80), 8-3 | Sportsman's Park III (7-4) | 64-51 | |
| » Starters: Archie McKain vs Jack Knott | Fourth | 15½ out |
| Tuesday, August 31 |
| » Lost to White Sox (69-53), 7-6 | Comiskey Park I (1-7) | 64-52 | Lost 2 |
| » Starters: Jack Wilson vs Vern Kennedy | Fourth | 16 out |
| Future Red Sox Tracy Stallard is born in Coeburn, VA. |
| Wednesday, September 1 |
| » Defeated White Sox (69-54), 2-0 | Comiskey Park I (2-7) | 65-52 | |
| » Starters: Lefty Grove vs Bill Dietrich | Fourth | 15 out |
| Thursday, September 2 |
| » Lost to White Sox (70-54), 4-2 | Comiskey Park I (2-8) | 65-53 | |
| » Starters: Johnny Marcum vs Thornton Lee | Fourth | 15½ out |
| » Lost to White Sox (71-54), 10-8 | Comiskey Park I (2-9) | 65-54 | Lost 2 |
| » Starters: Archie McKain vs John Whitehead | Fourth | 15½ out |
| Friday, September 3 |
| » Major-league debuts: Jimmy Wasdell (Senators) |
| Saturday, September 4 |
| » Defeated Athletics (39-81), 5-4 | Fenway Park (38-16) | 66-54 | |
| » Starters: George Caster vs Bobo Newsom | Fourth | 15½ out |
| » Lost to Athletics (40-81), 10-4 | Fenway Park (38-17) | 66-55 | |
| » Starters: Bud Thomas vs Jack Wilson | Fourth | 15½ out |
| Monday, September 6 |
| » Defeated Senators (56-66), 6-2 | Fenway Park (39-17) | 67-55 | |
| » Starters: Wes Ferrell vs Lefty Grove | Fourth | 17 out |
| » Lost to Senators (57-66), 2-0 | Fenway Park (39-18) | 67-56 | |
| » Starters: Bill Phebus vs Archie McKain | Fourth | 17 out |
| Tuesday, September 7 |
| » Lost to Senators (58-66), 11-5 | Fenway Park (39-19) | 67-57 | Lost 2 |
| » Starters: Jimmie DeShong vs Rube Walberg | Fourth | 18 out |
| » Lost to Senators (59-66), 5-4 | Fenway Park (39-20) | 67-58 | Lost 3 |
| » Starters: Monte Weaver vs Johnny Marcum | Fourth | 18 out |
| Wednesday, September 8 |
| » Lost to Yankees (86-40), 3-2 | Yankee Stadium (1-4) | 67-59 | Lost 4 |
| » Starters: Bobo Newsom vs Red Ruffing | Fourth | 20 out |
| » Lost to Yankees (87-40), 9-6 | Yankee Stadium (1-5) | 67-60 | Lost 5 |
| » Starters: Jack Wilson vs Monte Pearson | Fourth | 20 out |
| Thursday, September 9 |
| » Defeated Yankees (87-41), 13-7 | Yankee Stadium (2-5) | 68-60 | |
| » Starters: Archie McKain vs Pat Malone | Fourth | 19 out |
| Friday, September 10 |
| » Defeated Yankees (87-42), 4-3 | Yankee Stadium (3-5) | 69-60 | Won 2 |
| » Starters: Lefty Grove vs Ivy Andrews | Fourth | 18 out |
| Saturday, September 11 |
| » Defeated Athletics (42-87), 6-4 | Shibe Park (9-1) | 70-60 | Won 3 |
| » Starters: Bobo Newsom vs Eddie Smith | Fourth | 18 out |
| Sunday, September 12 |
| » Defeated Athletics (42-88), 13-6 | Shibe Park (10-1) | 71-60 | Won 4 |
| » Starters: Jack Wilson vs George Caster | Fourth | 17½ out |
| Wednesday, September 15 |
| » Lost to White Sox (77-59), 5-3 | Fenway Park (39-21) | 71-61 | |
| » Starters: Bill Dietrich vs Lefty Grove | Fourth | 18½ out |
| Friday, September 17 |
| » Lost to Indians (73-65), 4-1 | Fenway Park (39-22) | 71-62 | Lost 2 |
| » Starters: Johnny Allen vs Bobo Newsom | Fourth | 19½ out |
| Future Red Sox Orlando Cepeda is born in Ponce, P.R. |
| Saturday, September 18 |
| » Lost to Indians (74-65), 7-6 | Fenway Park (39-23) | 71-63 | Lost 3 |
| » Starters: Mel Harder vs Archie McKain | Fifth | 21 out |
| Monday, September 20 |
| » Lost to Browns (42-98), 8-6 | Fenway Park (39-24) | 71-64 | Lost 4 |
| » Starters: Bill Trotter vs Johnny Marcum | Fourth | 21 out |
| » Defeated Browns (42-99), 7-5 | Fenway Park (40-24) | 72-64 | |
| » Starters: Jim Walkup vs Joe Gonzales | Fourth | 21 out |
| Tuesday, September 21 |
| » Defeated Tigers (83-58), 12-7 | Fenway Park (41-24) | 73-64 | Won 2 |
| » Starters: Boots Poffenberger vs Lefty Grove | Fourth | 21 out |
| » Lost to Tigers (84-58), 4-1 | Fenway Park (41-25) | 73-65 | |
| » Starters: George Gill vs Jack Wilson | Fourth | 21 out |
| Wednesday, September 22 |
| » Lost to Tigers (85-58), 6-4 | Fenway Park (41-26) | 73-66 | Lost 2 |
| » Starters: Tommy Bridges vs Bobo Newsom | Fourth | 22½ out |
| Thursday, September 23 |
| » Defeated Tigers (85-59), 4-3 | Fenway Park (42-26) | 74-66 | |
| » Starters: Elden Auker vs Jim Henry | Fourth | 21½ out |
| » Major-league debuts: Johnny Peacock (Red Sox) |
| Friday, September 24 |
| » Lost to Yankees (98-46), 5-1 | Fenway Park (42-27) | 74-67 | |
| » Starters: Joe Vance vs Archie McKain | Fourth | 22½ out |
| Saturday, September 25 |
| » Lost to Yankees (99-46), 5-2 | Fenway Park (42-28) | 74-68 | Lost 2 |
| » Starters: Lefty Gomez vs Lefty Grove | Fifth | 23½ out |
| Sunday, September 26 |
| » Defeated Yankees (99-47), 7-2 | Fenway Park (43-28) | 75-68 | |
| » Starters: Bump Hadley vs Jack Wilson | Fifth | 22½ out |
| Monday, September 27 |
| » Defeated Athletics (48-95), 6-2 | Fenway Park (44-28) | 76-68 | Won 2 |
| » Starters: George Caster vs Bobo Newsom | Fifth | 22½ out |
| » Lost to Athletics (49-95), 6-0 | Fenway Park (44-29) | 76-69 | |
| » Starters: Bud Thomas vs Bobo Newsom | Fifth | 22½ out |
| Wednesday, September 29 |
| » Defeated Senators (71-76), 3-1 | Griffith Stadium (2-8) | 77-69 | |
| » Starters: Lefty Grove vs Jimmie DeShong | Fourth | 21½ out |
| » Defeated Senators (71-77), 7-4 | Griffith Stadium (3-8) | 78-69 | Won 2 |
| » Starters: Jim Henry vs Pete Appleton | Fourth | 21½ out |
| Thursday, September 30 |
| » Lost to Senators (72-77), 4-3 | Griffith Stadium (3-9) | 78-70 | |
| » Starters: Archie McKain vs Wes Ferrell | Fifth | 20½ out |
| » Defeated Senators (72-78), 9-3 | Griffith Stadium (4-9) | 79-70 | |
| » Starters: Jack Wilson vs Bill Phebus | Fifth | 20½ out |
| Friday, October 1 |
| » Defeated Yankees (101-52), 4-2 | Yankee Stadium (4-5) | 80-70 | Won 2 |
| » Starters: Bobo Newsom vs Lefty Gomez | Fifth | 19½ out |
| Saturday, October 2 |
| » Lost to Yankees (102-52), 11-3 | Yankee Stadium (4-6) | 80-71 | |
| » Starters: Johnny Marcum vs Red Ruffing | Fifth | 20½ out |
| Sunday, October 3 |
| » Lost to Yankees (103-52), 6-1 | Yankee Stadium (4-7) | 80-72 | Lost 2 |
| » Starters: Joe Gonzales vs Monte Pearson | Fifth | 21½ out |
| Wednesday, October 13 |
| Future Red Sox Lu Clinton is born in Ponca City, OK. |
| Monday, October 18 |
| Former Red Sox Charlie Starr dies in Pasadena, CA at the age of 60. |
| Wednesday, October 20 |
| Future Red Sox Juan Marichal is born in Laguna Verde, D.R. |
| Monday, October 25 |
| Future Red Sox Chuck Schilling is born in Brooklyn, NY. |
| Monday, November 15 |
| Future Red Sox Ray Webster is born in Grass Valley, CA. |
| Saturday, November 27 |
| Future Red Sox Bill Short is born in Kingston, NY. |
| Monday, November 29 |
| Future Red Sox George Thomas is born in Minneapolis, MN. |
| Wednesday, December 8 |
| Future Red Sox Jim Pagliaroni is born in Dearborn, MI. |
Game information provided by Retrosheet (www.retrosheet.org) |
