| Sunday, April 5 |
| Future White Sox Jimmie Schaffer is born in Limeport, PA. |
| Tuesday, April 14 |
| » Defeated Browns (0-1), 7-6 | Comiskey Park I (1-0) | 1-0 | |
| » Starters: Ivy Andrews vs John Whitehead | First | -- |
| Wednesday, April 15 |
| » Defeated Browns (0-2), 6-3 | Comiskey Park I (2-0) | 2-0 | Won 2 |
| » Starters: Jack Knott vs Monty Stratton | First | -- |
| Friday, April 17 |
| » Defeated Tigers (1-2), 5-3 | Tiger Stadium (1-0) | 3-0 | Won 3 |
| » Starters: John Whitehead vs Elden Auker | First | -- |
| Sunday, April 19 |
| » Lost to Tigers (2-2), 5-0 | Tiger Stadium (1-1) | 3-1 | |
| » Starters: Monty Stratton vs Schoolboy Rowe | Second | ½ out |
| Monday, April 20 |
| » Defeated Indians (4-2), 5-1 | Comiskey Park I (3-0) | 4-1 | |
| » Starters: Oral Hildebrand vs Vern Kennedy | First | -- |
| Thursday, April 23 |
| » Lost to Indians (5-2), 6-0 | League Park II (0-1) | 4-2 | |
| » Starters: John Whitehead vs Johnny Allen | Third | ½ out |
| Friday, April 24 |
| » Lost to Indians (6-2), 6-2 | League Park II (0-2) | 4-3 | Lost 2 |
| » Starters: Monty Stratton vs Mel Harder | Fourth | 1½ out |
| Saturday, April 25 |
| » Lost to Tigers (5-4), 8-6 | Comiskey Park I (3-1) | 4-4 | Lost 3 |
| » Starters: Roxie Lawson vs Vern Kennedy | Fifth | 2 out |
| Sunday, April 26 |
| » Lost to Tigers (6-4), 6-4 | Comiskey Park I (3-2) | 4-5 | Lost 4 |
| » Starters: Vic Sorrell vs John Whitehead | Sixth | 2½ out |
| Tuesday, April 28 |
| » Lost to Red Sox (9-5), 11-8 | Fenway Park (0-1) | 4-6 | Lost 5 |
| » Starters: Monty Stratton vs Johnny Welch | Sixth | 3 out |
| Wednesday, April 29 |
| » Lost to Red Sox (10-5), 8-7 | Fenway Park (0-2) | 4-7 | Lost 6 |
| » Starters: Vern Kennedy vs Wes Ferrell | Seventh | 4 out |
| Thursday, April 30 |
| » Lost to Red Sox (11-5), 16-4 | Fenway Park (0-3) | 4-8 | Lost 7 |
| » Starters: John Whitehead vs Joe Cascarella | Seventh | 5 out |
| Friday, May 1 |
| » Lost to Yankees (11-5), 3-2 | Yankee Stadium (0-1) | 4-9 | Lost 8 |
| » Starters: Ted Lyons vs Johnny Broaca | Seventh | 6 out |
| Saturday, May 2 |
| » Defeated Yankees (11-6), 6-4 | Yankee Stadium (1-1) | 5-9 | |
| » Starters: Monty Stratton vs Red Ruffing | Seventh | 5 out |
| Sunday, May 3 |
| » Defeated Athletics (6-11), 8-4 | Shibe Park (1-0) | 6-9 | Won 2 |
| » Starters: John Whitehead vs Gordon Rhodes | Sixth | 5 out |
| Tuesday, May 5 |
| » Lost to Athletics (7-11), 8-5 | Shibe Park (1-1) | 6-10 | |
| » Starters: Vern Kennedy vs Harry Kelley | Seventh | 6 out |
| Wednesday, May 6 |
| » Defeated Senators (11-12), 5-1 | Griffith Stadium (1-0) | 7-10 | |
| » Starters: Ted Lyons vs Ed Linke | Sixth | 6 out |
| Thursday, May 7 |
| » Defeated Senators (11-13), 11-6 | Griffith Stadium (2-0) | 8-10 | Won 2 |
| » Starters: Monty Stratton vs Bobo Newsom | Sixth | 6 out |
| Saturday, May 9 |
| » Defeated Browns (3-19), 7-3 | Sportsman's Park III (1-0) | 9-10 | Won 3 |
| » Starters: Sugar Cain vs Les Tietje | Fifth | 5½ out |
| Future White Sox Floyd Robinson is born in Prescott, AR. |
| Monday, May 11 |
| » Defeated Browns (3-20), 19-6 | Sportsman's Park III (2-0) | 10-10 | Won 4 |
| » Starters: John Whitehead vs Roy Mahaffey | Fourth | 5 out |
| Thursday, May 14 |
| » Defeated Senators (13-15), 13-12 | Comiskey Park I (4-2) | 11-10 | Won 5 |
| » Starters: Jack Russell vs Monty Stratton | Fourth | 5 out |
| Friday, May 15 |
| » Defeated Yankees (19-9), 9-7 | Comiskey Park I (5-2) | 12-10 | Won 6 |
| » Starters: Johnny Broaca vs Sugar Cain | Fourth | 4 out |
| Saturday, May 16 |
| » Lost to Yankees (20-9), 8-2 | Comiskey Park I (5-3) | 12-11 | |
| » Starters: Bump Hadley vs Ted Lyons | Fourth | 5 out |
| Sunday, May 17 |
| » Lost to Red Sox (20-11), 8-7 | Comiskey Park I (5-4) | 12-12 | Lost 2 |
| » Starters: Jim Henry vs John Whitehead | Fourth | 6 out |
| Monday, May 18 |
| » Lost to Red Sox (21-11), 2-0 | Comiskey Park I (5-5) | 12-13 | Lost 3 |
| » Starters: Lefty Grove vs Vern Kennedy | Fifth | 6½ out |
| Tuesday, May 19 |
| » Lost to Red Sox (22-11), 4-2 | Comiskey Park I (5-6) | 12-14 | Lost 4 |
| » Starters: Johnny Marcum vs Monty Stratton | Fifth | 7½ out |
| Wednesday, May 20 |
| » Defeated Athletics (10-19), 4-0 | Comiskey Park I (6-6) | 13-14 | |
| » Starters: Buck Ross vs Sugar Cain | Fifth | 6½ out |
| Thursday, May 21 |
| » Defeated Athletics (10-20), 3-2 | Comiskey Park I (7-6) | 14-14 | Won 2 |
| » Starters: Harry Kelley vs John Whitehead | Fifth | 5½ out |
| Future White Sox Barry Latman is born in Los Angeles, CA. |
| Friday, May 22 |
| » Defeated Browns (7-26), 5-3 | Comiskey Park I (8-6) | 15-14 | Won 3 |
| » Starters: Ivy Andrews vs Ted Lyons | Fifth | 5 out |
| Saturday, May 23 |
| » Defeated Browns (7-27), 8-3 | Comiskey Park I (9-6) | 16-14 | Won 4 |
| » Starters: Roy Mahaffey vs Vern Kennedy | Fifth | 6 out |
| » Lost to Browns (8-27), 5-1 | Comiskey Park I (9-7) | 16-15 | |
| » Starters: Jack Knott vs Monty Stratton | Fifth | 6 out |
| Sunday, May 24 |
| » Defeated Browns (8-28), 7-5 | Comiskey Park I (10-7) | 17-15 | |
| » Starters: Tommy Thomas vs Ray Phelps | Fifth | 6 out |
| Tuesday, May 26 |
| » Lost to Tigers (21-16), 12-9 | Tiger Stadium (1-2) | 17-16 | |
| » Starters: John Whitehead vs Alvin Crowder | Fourth | 5 out |
| » Defeated Tigers (21-17), 9-2 | Tiger Stadium (2-2) | 18-16 | |
| » Starters: Sugar Cain vs Elden Auker | Fourth | 5 out |
| Wednesday, May 27 |
| » Lost to Tigers (22-17), 3-2 | Tiger Stadium (2-3) | 18-17 | |
| » Starters: Ted Lyons vs Tommy Bridges | Fifth | 6 out |
| Thursday, May 28 |
| » Defeated Tigers (22-18), 6-5 | Tiger Stadium (3-3) | 19-17 | |
| » Starters: Vern Kennedy vs Vic Sorrell | Fifth | 6 out |
| Friday, May 29 |
| » Lost to Tigers (23-18), 4-3 | Tiger Stadium (3-4) | 19-18 | |
| » Starters: Ray Phelps vs Red Phillips | Fifth | 6½ out |
| Saturday, May 30 |
| » Lost to Indians (22-17), 4-3 | League Park II (0-3) | 19-19 | Lost 2 |
| » Starters: John Whitehead vs Lloyd Brown | Sixth | 8½ out |
| » Lost to Indians (23-17), 11-3 | League Park II (0-4) | 19-20 | Lost 3 |
| » Starters: Sugar Cain vs George Blaeholder | Sixth | 8½ out |
| Sunday, May 31 |
| » Lost to Indians (24-17), 7-5 | Cleveland Stadium (0-1) | 19-21 | Lost 4 |
| » Starters: Vern Kennedy vs Mel Harder | Sixth | 9½ out |
| Tuesday, June 2 |
| » Defeated Yankees (30-14), 11-9 | Yankee Stadium (2-1) | 20-21 | |
| » Starters: Ted Lyons vs Pat Malone | Sixth | 8½ out |
| Wednesday, June 3 |
| » Lost to Yankees (31-14), 11-1 | Yankee Stadium (2-2) | 20-22 | |
| » Starters: Ray Phelps vs Red Ruffing | Fifth | 9½ out |
| Thursday, June 4 |
| » Defeated Yankees (31-15), 16-3 | Yankee Stadium (3-2) | 21-22 | |
| » Starters: John Whitehead vs Monte Pearson | Sixth | 8½ out |
| Friday, June 5 |
| » Lost to Red Sox (30-18), 8-6 | Fenway Park (0-4) | 21-23 | |
| » Starters: Sugar Cain vs Jack Wilson | Fifth | 9½ out |
| Saturday, June 6 |
| » Lost to Red Sox (31-18), 10-6 | Fenway Park (0-5) | 21-24 | Lost 2 |
| » Starters: Vern Kennedy vs Jim Henry | Sixth | 9½ out |
| Sunday, June 7 |
| » Defeated Red Sox (31-19), 13-5 | Fenway Park (1-5) | 22-24 | |
| » Starters: Ted Lyons vs Wes Ferrell | Sixth | 9½ out |
| Monday, June 8 |
| » Lost to Athletics (16-31), 5-4 | Shibe Park (1-2) | 22-25 | |
| » Starters: John Whitehead vs Buck Ross | Sixth | 10½ out |
| Tuesday, June 9 |
| » Defeated Athletics (16-32), 5-2 | Shibe Park (2-2) | 23-25 | |
| » Starters: Vern Kennedy vs Herman Fink | Sixth | 9½ out |
| Thursday, June 11 |
| » Lost to Senators (27-26), 2-0 | Griffith Stadium (2-1) | 23-26 | |
| » Starters: Sugar Cain vs Jimmie DeShong | Sixth | 10½ out |
| Friday, June 12 |
| » Lost to Senators (28-26), 6-0 | Griffith Stadium (2-2) | 23-27 | Lost 2 |
| » Starters: Ted Lyons vs Bobo Newsom | Sixth | 11½ out |
| Saturday, June 13 |
| » Defeated Senators (28-27), 15-2 | Griffith Stadium (3-2) | 24-27 | |
| » Starters: John Whitehead vs Ed Linke | Sixth | 11 out |
| Sunday, June 14 |
| » Defeated Senators (28-28), 6-4 | Griffith Stadium (4-2) | 25-27 | Won 2 |
| » Starters: Vern Kennedy vs Pete Appleton | Sixth | 10½ out |
| Tuesday, June 16 |
| » Defeated Red Sox (34-22), 4-2 | Comiskey Park I (11-7) | 26-27 | Won 3 |
| » Starters: Lefty Grove vs Sugar Cain | Fifth | 9½ out |
| Wednesday, June 17 |
| » Lost to Red Sox (35-22), 9-4 | Comiskey Park I (11-8) | 26-28 | |
| » Starters: Wes Ferrell vs Ted Lyons | Sixth | 11 out |
| Thursday, June 18 |
| » Defeated Red Sox (35-23), 1-0 | Comiskey Park I (12-8) | 27-28 | |
| » Starters: Johnny Marcum vs John Whitehead | Fifth | 11 out |
| Friday, June 19 |
| » Defeated Athletics (20-36), 5-4 | Comiskey Park I (13-8) | 28-28 | Won 2 |
| » Starters: Stu Flythe vs Vern Kennedy | Fourth | 11 out |
| Saturday, June 20 |
| » Lost to Athletics (21-36), 2-1 | Comiskey Park I (13-9) | 28-29 | |
| » Starters: Harry Kelley vs Sugar Cain | Sixth | 11 out |
| » Major-league debuts: Larry Rosenthal (White Sox) |
| Sunday, June 21 |
| » Lost to Athletics (22-36), 11-5 | Comiskey Park I (13-10) | 28-30 | Lost 2 |
| » Starters: Herman Fink vs Ray Phelps | Fifth | 11 out |
| Monday, June 22 |
| » Lost to Yankees (41-20), 9-6 | Comiskey Park I (13-11) | 28-31 | Lost 3 |
| » Starters: Monte Pearson vs John Whitehead | Sixth | 12 out |
| Tuesday, June 23 |
| » Defeated Yankees (41-21), 13-4 | Comiskey Park I (14-11) | 29-31 | |
| » Starters: Jumbo Brown vs Vern Kennedy | Sixth | 11 out |
| Wednesday, June 24 |
| » Lost to Yankees (42-21), 18-11 | Comiskey Park I (14-12) | 29-32 | |
| » Starters: Lefty Gomez vs Sugar Cain | Fifth | 12 out |
| Thursday, June 25 |
| » Lost to Yankees (43-21), 7-6 | Comiskey Park I (14-13) | 29-33 | Lost 2 |
| » Starters: Bump Hadley vs Ted Lyons | Sixth | 13 out |
| Saturday, June 27 |
| » Lost to Senators (35-31), 2-1 | Comiskey Park I (14-14) | 29-34 | Lost 3 |
| » Starters: Earl Whitehill vs John Whitehead | Fourth | 13½ out |
| » Defeated Senators (35-32), 7-3 | Comiskey Park I (15-14) | 30-34 | |
| » Starters: Jimmie DeShong vs Italo Chelini | Fourth | 13½ out |
| Sunday, June 28 |
| » Lost to Senators (36-32), 12-9 | Comiskey Park I (15-15) | 30-35 | |
| » Starters: Bobo Newsom vs Vern Kennedy | Fifth | 13½ out |
| » Defeated Senators (36-33), 4-1 | Comiskey Park I (16-15) | 31-35 | |
| » Starters: Joe Cascarella vs Sugar Cain | Fifth | 13½ out |
| Wednesday, July 1 |
| » Lost to Tigers (37-32), 21-6 | Comiskey Park I (16-16) | 31-36 | |
| » Starters: Tommy Bridges vs Ted Lyons | Fifth | 15½ out |
| Thursday, July 2 |
| » Lost to Tigers (38-32), 7-1 | Comiskey Park I (16-17) | 31-37 | Lost 2 |
| » Starters: Schoolboy Rowe vs John Whitehead | Sixth | 16½ out |
| Friday, July 3 |
| » Defeated Indians (38-34), 6-5 | Comiskey Park I (17-17) | 32-37 | |
| » Starters: George Blaeholder vs Italo Chelini | Fifth | 16 out |
| Saturday, July 4 |
| » Defeated Indians (38-35), 9-2 | Comiskey Park I (18-17) | 33-37 | Won 2 |
| » Starters: Thornton Lee vs Vern Kennedy | Sixth | 16 out |
| » Defeated Indians (38-36), 8-4 | Comiskey Park I (19-17) | 34-37 | Won 3 |
| » Starters: Willis Hudlin vs Sugar Cain | Sixth | 16 out |
| Sunday, July 5 |
| » Lost to Indians (39-36), 11-4 | Comiskey Park I (19-18) | 34-38 | |
| » Starters: Mel Harder vs Clint Brown | Sixth | 15½ out |
| » Defeated Indians (39-37), 4-2 | Comiskey Park I (20-18) | 35-38 | |
| » Starters: Lloyd Brown vs John Whitehead | Sixth | 15½ out |
| Thursday, July 9 |
| » Lost to Red Sox (43-34), 7-2 | Fenway Park (1-6) | 35-39 | |
| » Starters: John Whitehead vs Wes Ferrell | Sixth | 15½ out |
| Friday, July 10 |
| » Defeated Red Sox (43-35), 8-2 | Fenway Park (2-6) | 36-39 | |
| » Starters: Vern Kennedy vs Johnny Marcum | Sixth | 15½ out |
| Saturday, July 11 |
| » Defeated Red Sox (43-36), 9-1 | Fenway Park (3-6) | 37-39 | Won 2 |
| » Starters: Sugar Cain vs Jack Wilson | Sixth | 14½ out |
| Sunday, July 12 |
| » Defeated Yankees (52-26), 5-0 | Yankee Stadium (4-2) | 38-39 | Won 3 |
| » Starters: Ted Lyons vs Johnny Broaca | Sixth | 14½ out |
| » Lost to Yankees (53-26), 5-4 | Yankee Stadium (4-3) | 38-40 | |
| » Starters: Italo Chelini vs Bump Hadley | Sixth | 14½ out |
| Monday, July 13 |
| » Defeated Yankees (53-27), 6-3 | Yankee Stadium (5-3) | 39-40 | |
| » Starters: John Whitehead vs Monte Pearson | Fifth | 13½ out |
| Wednesday, July 15 |
| » Defeated Senators (44-38), 6-4 | Griffith Stadium (5-2) | 40-40 | Won 2 |
| » Starters: Vern Kennedy vs Jimmie DeShong | Sixth | 13 out |
| Thursday, July 16 |
| » Defeated Senators (44-39), 9-7 | Griffith Stadium (6-2) | 41-40 | Won 3 |
| » Starters: Sugar Cain vs Pete Appleton | Sixth | 13 out |
| Future White Sox Eddie Fisher is born in Shreveport, LA. |
| Friday, July 17 |
| » Defeated Senators (44-40), 16-5 | Griffith Stadium (7-2) | 42-40 | Won 4 |
| » Starters: Italo Chelini vs Earl Whitehill | Sixth | 13 out |
| Saturday, July 18 |
| » Defeated Athletics (28-54), 7-4 | Shibe Park (3-2) | 43-40 | Won 5 |
| » Starters: Ted Lyons vs Harry Kelley | Fifth | 12 out |
| » Defeated Athletics (28-55), 21-14 | Shibe Park (4-2) | 44-40 | Won 6 |
| » Starters: John Whitehead vs Buck Ross | Fifth | 12 out |
| Sunday, July 19 |
| » Defeated Athletics (28-56), 11-5 | Shibe Park (5-2) | 45-40 | Won 7 |
| » Starters: Vern Kennedy vs Gordon Rhodes | Fourth | 11 out |
| » Defeated Athletics (28-57), 8-2 | Shibe Park (6-2) | 46-40 | Won 8 |
| » Starters: Sugar Cain vs Herman Fink | Fourth | 11 out |
| Tuesday, July 21 |
| » Lost to Senators (46-42), 6-5 | Comiskey Park I (20-19) | 46-41 | |
| » Starters: Jimmie DeShong vs Italo Chelini | Fifth | 11 out |
| Wednesday, July 22 |
| » Defeated Senators (46-43), 3-2 | Comiskey Park I (21-19) | 47-41 | |
| » Starters: Earl Whitehill vs John Whitehead | Fourth | 10 out |
| Thursday, July 23 |
| » Defeated Senators (46-44), 7-6 | Comiskey Park I (22-19) | 48-41 | Won 2 |
| » Starters: Bobo Newsom vs Vern Kennedy | Fourth | 10 out |
| Saturday, July 25 |
| » Lost to Yankees (60-32), 5-3 | Comiskey Park I (22-20) | 48-42 | |
| » Starters: Red Ruffing vs Ted Lyons | Fifth | 11 out |
| Sunday, July 26 |
| » Lost to Yankees (61-32), 12-3 | Comiskey Park I (22-21) | 48-43 | Lost 2 |
| » Starters: Johnny Broaca vs Sugar Cain | Fifth | 13 out |
| » Lost to Yankees (62-32), 11-8 | Comiskey Park I (22-22) | 48-44 | Lost 3 |
| » Starters: Bump Hadley vs John Whitehead | Fifth | 13 out |
| Monday, July 27 |
| » Lost to Athletics (32-62), 15-8 | Comiskey Park I (22-23) | 48-45 | Lost 4 |
| » Starters: Harry Kelley vs Vern Kennedy | Sixth | 13 out |
| Tuesday, July 28 |
| » Defeated Athletics (32-63), 19-6 | Comiskey Park I (23-23) | 49-45 | |
| » Starters: Carl Doyle vs Bill Dietrich | Fifth | 13 out |
| Wednesday, July 29 |
| » Defeated Athletics (32-64), 7-5 | Comiskey Park I (24-23) | 50-45 | Won 2 |
| » Starters: Herman Fink vs Sugar Cain | Fourth | 13 out |
| Thursday, July 30 |
| » Defeated Athletics (32-65), 7-4 | Comiskey Park I (25-23) | 51-45 | Won 3 |
| » Starters: Gordon Rhodes vs Vern Kennedy | Fourth | 12 out |
| Friday, July 31 |
| » Lost to Red Sox (54-46), 7-3 | Comiskey Park I (25-24) | 51-46 | |
| » Starters: Lefty Grove vs Ted Lyons | Fifth | 13 out |
| Saturday, August 1 |
| » Defeated Red Sox (54-47), 3-0 | Comiskey Park I (26-24) | 52-46 | |
| » Starters: Johnny Marcum vs Bill Dietrich | Fifth | 13 out |
| Sunday, August 2 |
| » Defeated Red Sox (54-48), 9-1 | Comiskey Park I (27-24) | 53-46 | Won 2 |
| » Starters: Jack Russell vs Sugar Cain | Third | 12 out |
| » Defeated Red Sox (54-49), 12-11 | Comiskey Park I (28-24) | 54-46 | Won 3 |
| » Starters: Wes Ferrell vs Vern Kennedy | Third | 12 out |
| Tuesday, August 4 |
| » Defeated Browns (35-66), 8-2 | Sportsman's Park III (3-0) | 55-46 | Won 4 |
| » Starters: Ted Lyons vs Tommy Thomas | Third | 12 out |
| Wednesday, August 5 |
| » Lost to Browns (36-66), 16-4 | Sportsman's Park III (3-1) | 55-47 | |
| » Starters: Vern Kennedy vs Ivy Andrews | Third | 13 out |
| » Tied Browns, 9-9 | Sportsman's Park III (3-1) | 55-47 | |
| » Starters: Bill Dietrich vs Jack Knott | Third | 13 out |
| Thursday, August 6 |
| » Defeated Browns (36-67), 9-6 | Sportsman's Park III (4-1) | 56-47 | |
| » Starters: Sugar Cain vs Jack Knott | Third | 12 out |
| » Defeated Browns (36-68), 4-1 | Sportsman's Park III (5-1) | 57-47 | Won 2 |
| » Starters: Bill Dietrich vs Chief Hogsett | Third | 12 out |
| Friday, August 7 |
| » Lost to Indians (59-47), 8-1 | League Park II (0-5) | 57-48 | |
| » Starters: Italo Chelini vs Denny Galehouse | Third | 12½ out |
| Future White Sox Jerry McNertney is born in Boone, IA. |
| Saturday, August 8 |
| » Defeated Indians (59-48), 9-7 | League Park II (1-5) | 58-48 | |
| » Starters: Vern Kennedy vs Mel Harder | Third | 12½ out |
| Sunday, August 9 |
| » Lost to Indians (60-48), 9-1 | Cleveland Stadium (0-2) | 58-49 | |
| » Starters: Ted Lyons vs Johnny Allen | Third | 14½ out |
| » Lost to Indians (61-48), 5-2 | Cleveland Stadium (0-3) | 58-50 | Lost 2 |
| » Starters: Bill Dietrich vs Oral Hildebrand | Third | 14½ out |
| Tuesday, August 11 |
| » Lost to Browns (39-69), 7-2 | Comiskey Park I (28-25) | 58-51 | Lost 3 |
| » Starters: Ivy Andrews vs Sugar Cain | Third | 14 out |
| Wednesday, August 12 |
| » Defeated Browns (39-70), 8-3 | Comiskey Park I (29-25) | 59-51 | |
| » Starters: Jack Knott vs Vern Kennedy | Third | 14 out |
| Thursday, August 13 |
| » Lost to Browns (40-70), 7-3 | Comiskey Park I (29-26) | 59-52 | |
| » Starters: Tommy Thomas vs John Whitehead | Third | 14½ out |
| Saturday, August 15 |
| » Lost to Tigers (59-52), 3-1 | Comiskey Park I (29-27) | 59-53 | Lost 2 |
| » Starters: Elden Auker vs Bill Dietrich | Fourth | 15½ out |
| » Lost to Tigers (60-52), 10-3 | Comiskey Park I (29-28) | 59-54 | Lost 3 |
| » Starters: Jake Wade vs Sugar Cain | Fourth | 15½ out |
| Sunday, August 16 |
| » Lost to Tigers (61-52), 6-4 | Comiskey Park I (29-29) | 59-55 | Lost 4 |
| » Starters: Tommy Bridges vs Vern Kennedy | Fourth | 16½ out |
| » Lost to Tigers (62-52), 8-6 | Comiskey Park I (29-30) | 59-56 | Lost 5 |
| » Starters: Schoolboy Rowe vs John Whitehead | Fourth | 16½ out |
| Monday, August 17 |
| » Defeated Indians (64-52), 7-3 | Comiskey Park I (30-30) | 60-56 | |
| » Starters: Johnny Allen vs Ted Lyons | Fourth | 15½ out |
| Future White Sox John Buzhardt is born in Prosperity, SC. |
| Tuesday, August 18 |
| » Defeated Indians (64-53), 11-10 | Comiskey Park I (31-30) | 61-56 | Won 2 |
| » Starters: Oral Hildebrand vs Clint Brown | Fourth | 14½ out |
| Friday, August 21 |
| » Lost to Tigers (65-54), 8-6 | Tiger Stadium (3-5) | 61-57 | |
| » Starters: Bill Dietrich vs Schoolboy Rowe | Fourth | 16 out |
| Saturday, August 22 |
| » Defeated Tigers (65-55), 9-3 | Tiger Stadium (4-5) | 62-57 | |
| » Starters: Vern Kennedy vs Elden Auker | Fourth | 16 out |
| Sunday, August 23 |
| » Defeated Tigers (65-56), 4-2 | Tiger Stadium (5-5) | 63-57 | Won 2 |
| » Starters: John Whitehead vs Jake Wade | Fourth | 15½ out |
| Monday, August 24 |
| » Defeated Tigers (65-57), 8-4 | Tiger Stadium (6-5) | 64-57 | Won 3 |
| » Starters: Ted Lyons vs Tommy Bridges | Fourth | 15 out |
| Tuesday, August 25 |
| » Lost to Athletics (44-78), 13-11 | Shibe Park (6-3) | 64-58 | |
| » Starters: Sugar Cain vs Stu Flythe | Fourth | 16 out |
| Wednesday, August 26 |
| » Defeated Athletics (44-79), 6-3 | Shibe Park (7-3) | 65-58 | |
| » Starters: Vern Kennedy vs Herman Fink | Fourth | 15 out |
| Thursday, August 27 |
| » Lost to Athletics (45-79), 5-2 | Shibe Park (7-4) | 65-59 | |
| » Starters: Bill Dietrich vs Randy Gumpert | Fourth | 16 out |
| Friday, August 28 |
| » Defeated Senators (64-61), 6-5 | Griffith Stadium (8-2) | 66-59 | |
| » Starters: John Whitehead vs Pete Appleton | Fourth | 16½ out |
| Saturday, August 29 |
| » Defeated Senators (64-62), 5-4 | Griffith Stadium (9-2) | 67-59 | Won 2 |
| » Starters: Sugar Cain vs Jimmie DeShong | Third | 16½ out |
| Sunday, August 30 |
| » Lost to Yankees (84-42), 8-1 | Yankee Stadium (5-4) | 67-60 | |
| » Starters: Ted Lyons vs Bump Hadley | Fourth | 18½ out |
| » Lost to Yankees (85-42), 4-1 | Yankee Stadium (5-5) | 67-61 | Lost 2 |
| » Starters: Vern Kennedy vs Monte Pearson | Fourth | 18½ out |
| Monday, August 31 |
| » Lost to Yankees (86-42), 5-1 | Yankee Stadium (5-6) | 67-62 | Lost 3 |
| » Starters: Bill Dietrich vs Johnny Broaca | Fourth | 19½ out |
| Thursday, September 3 |
| » Defeated Red Sox (65-66), 3-2 | Fenway Park (4-6) | 68-62 | |
| » Starters: John Whitehead vs Wes Ferrell | Fourth | 19½ out |
| » Lost to Red Sox (66-66), 5-0 | Fenway Park (4-7) | 68-63 | |
| » Starters: Sugar Cain vs Johnny Marcum | Fourth | 19½ out |
| Saturday, September 5 |
| » Defeated Indians (70-61), 9-0 | Comiskey Park I (32-30) | 69-63 | |
| » Starters: Oral Hildebrand vs Vern Kennedy | Fourth | 19 out |
| Sunday, September 6 |
| » Defeated Indians (70-62), 15-1 | Comiskey Park I (33-30) | 70-63 | Won 2 |
| » Starters: Mel Harder vs Ted Lyons | Second | 17 out |
| » Defeated Indians (70-63), 6-3 | Comiskey Park I (34-30) | 71-63 | Won 3 |
| » Starters: Johnny Allen vs Monty Stratton | Second | 17 out |
| Monday, September 7 |
| » Lost to Tigers (72-63), 8-7 | Comiskey Park I (34-31) | 71-64 | |
| » Starters: Schoolboy Rowe vs John Whitehead | Second | 18 out |
| » Defeated Tigers (72-64), 8-7 | Comiskey Park I (35-31) | 72-64 | |
| » Starters: Tommy Bridges vs Bill Dietrich | Second | 18 out |
| Future White Sox Chuck Lindstrom is born in Chicago, IL. |
| Tuesday, September 8 |
| » Defeated Tigers (72-65), 7-5 | Comiskey Park I (36-31) | 73-64 | Won 2 |
| » Starters: Elden Auker vs Sugar Cain | Second | 17½ out |
| Wednesday, September 9 |
| » Defeated Red Sox (70-69), 3-2 | Comiskey Park I (37-31) | 74-64 | Won 3 |
| » Starters: Rube Walberg vs Vern Kennedy | Second | 18 out |
| » Major-league debuts: Fabian Gaffke (Red Sox) |
| Friday, September 11 |
| » Defeated Athletics (49-90), 17-2 | Comiskey Park I (38-31) | 75-64 | Won 4 |
| » Starters: Hod Lisenbee vs Monty Stratton | Second | 17½ out |
| Former White Sox Braggo Roth dies in Chicago, IL at the age of 45. |
| Saturday, September 12 |
| » Defeated Athletics (49-91), 5-1 | Comiskey Park I (39-31) | 76-64 | Won 5 |
| » Starters: Buck Ross vs John Whitehead | Second | 16½ out |
| Sunday, September 13 |
| » Major-league debuts: Jeff Heath (Indians) |
| Monday, September 14 |
| » Defeated Senators (75-67), 5-4 | Comiskey Park I (40-31) | 77-64 | Won 6 |
| » Starters: Pete Appleton vs Ted Lyons | Second | 16½ out |
| » Defeated Senators (75-68), 11-3 | Comiskey Park I (41-31) | 78-64 | Won 7 |
| » Starters: Joe Cascarella vs Vern Kennedy | Second | 16½ out |
| Tuesday, September 15 |
| » Lost to Yankees (96-48), 7-1 | Comiskey Park I (41-32) | 78-65 | |
| » Starters: Monte Pearson vs Sugar Cain | Second | 17½ out |
| Wednesday, September 16 |
| » Major-league debuts: Birdie Tebbetts (Tigers) |
| Thursday, September 17 |
| » Lost to Browns (52-90), 5-2 | Sportsman's Park III (5-2) | 78-66 | Lost 2 |
| » Starters: Monty Stratton vs Jack Knott | Second | 18 out |
| Friday, September 18 |
| » Lost to Browns (53-90), 6-5 | Sportsman's Park III (5-3) | 78-67 | Lost 3 |
| » Starters: John Whitehead vs Tommy Thomas | Second | 18½ out |
| Sunday, September 20 |
| » Lost to Browns (54-90), 8-5 | Sportsman's Park III (5-4) | 78-68 | Lost 4 |
| » Starters: Ted Lyons vs Ivy Andrews | Third | 20 out |
| » Lost to Browns (55-90), 9-3 | Sportsman's Park III (5-5) | 78-69 | Lost 5 |
| » Starters: Vern Kennedy vs Chief Hogsett | Third | 20 out |
| Tuesday, September 22 |
| » Tied Indians, 8-8 | League Park II (1-5) | 78-69 | |
| » Starters: Monty Stratton vs Denny Galehouse | Third | 20½ out |
| Wednesday, September 23 |
| » Lost to Indians (77-72), 17-2 | League Park II (1-6) | 78-70 | Lost 6 |
| » Starters: Vern Kennedy vs Bob Feller | Fourth | 21 out |
| » Defeated Indians (77-73), 8-3 | League Park II (2-6) | 79-70 | |
| » Starters: Bill Dietrich vs Mel Harder | Fourth | 21 out |
| Saturday, September 26 |
| » Defeated Browns (57-94), 5-3 | Comiskey Park I (42-32) | 80-70 | Won 2 |
| » Starters: Jack Knott vs Ted Lyons | Third | 20½ out |
| » Defeated Browns (57-95), 8-6 | Comiskey Park I (43-32) | 81-70 | Won 3 |
| » Starters: Earl Caldwell vs Monty Stratton | Third | 20½ out |
| Tuesday, September 29 |
| Future White Sox Hal Trosky is born in Cleveland, OH. |
| Saturday, October 3 |
| Future White Sox Jack Lamabe is born in Farmingdale, NY. |
| Thursday, October 22 |
| Former White Sox Fred Olmstead dies in Muskogee, OK at the age of 56. |
| Tuesday, October 27 |
| Future White Sox Lee Stange is born in Chicago, IL. |
| Tuesday, November 17 |
| Future White Sox Gary Bell is born in San Antonio, TX. |
| Sunday, December 13 |
| Future White Sox J.C. Martin is born in Axton, VA. |
| Thursday, December 17 |
| Future White Sox Jerry Adair is born in Sand Springs, OK. |
| Saturday, December 26 |
| Future White Sox Wayne Causey is born in Ruston, LA. |
Game information provided by Retrosheet (www.retrosheet.org) |
