| Friday, January 24 |
| Future Red Sox Dick Stigman is born in Nimrod, MN. |
| Wednesday, February 5 |
| Future Red Sox Lee Thomas is born in Peoria, IL. |
| Monday, March 2 |
| Future Red Sox Don Schwall is born in Wilkes-Barre, PA. |
| Saturday, March 7 |
| Future Red Sox Galen Cisco is born in St. Marys, OH. |
| Tuesday, April 14 |
| » Defeated Athletics (0-1), 9-4 | Fenway Park (1-0) | 1-0 | |
| » Starters: Bill Dietrich vs Wes Ferrell | First | -- |
| Thursday, April 16 |
| » Defeated Athletics (0-2), 10-4 | Fenway Park (2-0) | 2-0 | Won 2 |
| » Starters: Hank Johnson vs Johnny Welch | First | -- |
| Friday, April 17 |
| » Defeated Yankees (1-3), 8-0 | Yankee Stadium (1-0) | 3-0 | Won 3 |
| » Starters: Lefty Grove vs Red Ruffing | First | -- |
| » Major-league debuts: Steve Sundra (Yankees) |
| Saturday, April 18 |
| » Lost to Yankees (2-3), 3-2 | Yankee Stadium (1-1) | 3-1 | |
| » Starters: Fritz Ostermueller vs Lefty Gomez | Third | ½ out |
| Sunday, April 19 |
| » Defeated Athletics (0-5), 2-1 | Shibe Park (1-0) | 4-1 | |
| » Starters: Wes Ferrell vs Gordon Rhodes | First | -- |
| Monday, April 20 |
| » Defeated Senators (4-3), 6-5 | Fenway Park (3-0) | 5-1 | Won 2 |
| » Starters: Ed Linke vs Rube Walberg | Second | 1 out |
| » Lost to Senators (5-3), 6-2 | Fenway Park (3-1) | 5-2 | |
| » Starters: Pete Appleton vs Johnny Welch | Second | 1 out |
| Tuesday, April 21 |
| » Defeated Senators (5-4), 8-1 | Fenway Park (4-1) | 6-2 | |
| » Starters: Joe Bokina vs Lefty Grove | Second | 1½ out |
| Wednesday, April 22 |
| » Defeated Senators (5-5), 4-3 | Fenway Park (5-1) | 7-2 | Won 2 |
| » Starters: Bobo Newsom vs Fritz Ostermueller | Second | 2 out |
| Thursday, April 23 |
| » Lost to Athletics (2-6), 9-1 | Shibe Park (1-1) | 7-3 | |
| » Starters: Wes Ferrell vs Harry Kelley | Second | 1½ out |
| Friday, April 24 |
| » Lost to Athletics (3-6), 3-1 | Shibe Park (1-2) | 7-4 | Lost 2 |
| » Starters: Johnny Marcum vs Gordon Rhodes | Second | 1½ out |
| Saturday, April 25 |
| » Defeated Yankees (6-5), 7-2 | Fenway Park (6-1) | 8-4 | |
| » Starters: Monte Pearson vs Lefty Grove | First | -- |
| Sunday, April 26 |
| » Lost to Yankees (7-5), 12-9 | Fenway Park (6-2) | 8-5 | |
| » Starters: Johnny Broaca vs Fritz Ostermueller | Second | 1½ out |
| Tuesday, April 28 |
| » Defeated White Sox (4-6), 11-8 | Fenway Park (7-2) | 9-5 | |
| » Starters: Monty Stratton vs Johnny Welch | Second | 1 out |
| Wednesday, April 29 |
| » Defeated White Sox (4-7), 8-7 | Fenway Park (8-2) | 10-5 | Won 2 |
| » Starters: Vern Kennedy vs Wes Ferrell | First | -- |
| Thursday, April 30 |
| » Defeated White Sox (4-8), 16-4 | Fenway Park (9-2) | 11-5 | Won 3 |
| » Starters: John Whitehead vs Joe Cascarella | First | -- |
| Friday, May 1 |
| » Defeated Indians (8-7), 6-0 | Fenway Park (10-2) | 12-5 | Won 4 |
| » Starters: Mel Harder vs Lefty Grove | First | -- |
| Saturday, May 2 |
| » Lost to Indians (9-7), 7-3 | Fenway Park (10-3) | 12-6 | |
| » Starters: Oral Hildebrand vs Fritz Ostermueller | First | -- |
| Sunday, May 3 |
| » Defeated Tigers (9-7), 6-0 | Fenway Park (11-3) | 13-6 | |
| » Starters: Tommy Bridges vs Wes Ferrell | First | -- |
| Tuesday, May 5 |
| » Defeated Tigers (9-8), 2-0 | Fenway Park (12-3) | 14-6 | Won 2 |
| » Starters: Elden Auker vs Lefty Grove | First | -- |
| Wednesday, May 6 |
| » Defeated Browns (3-17), 7-4 | Fenway Park (13-3) | 15-6 | Won 3 |
| » Starters: Jim Walkup vs Johnny Marcum | First | -- |
| Thursday, May 7 |
| » Defeated Browns (3-18), 9-6 | Fenway Park (14-3) | 16-6 | Won 4 |
| » Starters: Russ VanAtta vs Wes Ferrell | First | -- |
| Friday, May 8 |
| » Lost to Senators (12-13), 12-9 | Griffith Stadium (0-1) | 16-7 | |
| » Starters: Fritz Ostermueller vs Jack Russell | First | -- |
| Saturday, May 9 |
| » Defeated Senators (12-14), 9-5 | Griffith Stadium (1-1) | 17-7 | |
| » Starters: Rube Walberg vs Pete Appleton | First | -- |
| Sunday, May 10 |
| » Lost to Senators (13-14), 4-0 | Griffith Stadium (1-2) | 17-8 | |
| » Starters: Lefty Grove vs Bobo Newsom | Second | ½ out |
| Tuesday, May 12 |
| » Lost to Tigers (12-11), 5-0 | Tiger Stadium (0-1) | 17-9 | Lost 2 |
| » Starters: Wes Ferrell vs Vic Sorrell | Second | ½ out |
| Wednesday, May 13 |
| » Defeated Tigers (12-12), 3-1 | Tiger Stadium (1-1) | 18-9 | |
| » Starters: Rube Walberg vs Schoolboy Rowe | Second | ½ out |
| Thursday, May 14 |
| » Defeated Tigers (12-13), 3-1 | Tiger Stadium (2-1) | 19-9 | Won 2 |
| » Starters: Lefty Grove vs Elden Auker | Second | ½ out |
| Friday, May 15 |
| » Lost to Indians (16-10), 7-2 | League Park II (0-1) | 19-10 | |
| » Starters: Johnny Marcum vs Oral Hildebrand | Second | ½ out |
| Saturday, May 16 |
| » Lost to Indians (17-10), 10-3 | League Park II (0-2) | 19-11 | Lost 2 |
| » Starters: Wes Ferrell vs Mel Harder | Second | 1½ out |
| Sunday, May 17 |
| » Defeated White Sox (12-12), 8-7 | Comiskey Park I (1-0) | 20-11 | |
| » Starters: Jim Henry vs John Whitehead | Second | 1½ out |
| Monday, May 18 |
| » Defeated White Sox (12-13), 2-0 | Comiskey Park I (2-0) | 21-11 | Won 2 |
| » Starters: Lefty Grove vs Vern Kennedy | Second | 1 out |
| Tuesday, May 19 |
| » Defeated White Sox (12-14), 4-2 | Comiskey Park I (3-0) | 22-11 | Won 3 |
| » Starters: Johnny Marcum vs Monty Stratton | Second | 1 out |
| Wednesday, May 20 |
| » Lost to Browns (7-24), 12-8 | Sportsman's Park III (0-1) | 22-12 | |
| » Starters: Wes Ferrell vs Tommy Thomas | Second | 1 out |
| Thursday, May 21 |
| » Defeated Browns (7-25), 6-2 | Sportsman's Park III (1-1) | 23-12 | |
| » Starters: Wes Ferrell vs Chief Hogsett | Second | 1 out |
| Saturday, May 23 |
| » Lost to Senators (18-18), 8-7 | Fenway Park (14-4) | 23-13 | |
| » Starters: Bobo Newsom vs Lefty Grove | Second | 1½ out |
| Sunday, May 24 |
| » Lost to Senators (19-18), 12-4 | Fenway Park (14-5) | 23-14 | Lost 2 |
| » Starters: Jack Russell vs Johnny Marcum | Second | 2½ out |
| Former Red Sox Ted Lewis dies in Durham, NH at the age of 64. |
| Monday, May 25 |
| » Defeated Senators (19-19), 6-0 | Fenway Park (15-5) | 24-14 | |
| » Starters: Jimmie DeShong vs Fritz Ostermueller | Second | 1½ out |
| Tuesday, May 26 |
| » Defeated Yankees (25-13), 5-4 | Fenway Park (16-5) | 25-14 | Won 2 |
| » Starters: Red Ruffing vs Wes Ferrell | Second | ½ out |
| Wednesday, May 27 |
| » Lost to Yankees (26-13), 9-8 | Fenway Park (16-6) | 25-15 | |
| » Starters: Johnny Broaca vs Johnny Marcum | Second | 1½ out |
| Thursday, May 28 |
| » Lost to Yankees (27-13), 10-6 | Fenway Park (16-7) | 25-16 | Lost 2 |
| » Starters: Pat Malone vs Fritz Ostermueller | Second | 2½ out |
| Saturday, May 30 |
| » Lost to Athletics (13-25), 6-4 | Shibe Park (1-3) | 25-17 | Lost 3 |
| » Starters: Wes Ferrell vs Herman Fink | Second | 3½ out |
| » Defeated Athletics (13-26), 6-2 | Shibe Park (2-3) | 26-17 | |
| » Starters: Jim Henry vs Buck Ross | Second | 3½ out |
| Sunday, May 31 |
| » Lost to Yankees (30-13), 5-4 | Yankee Stadium (1-2) | 26-18 | |
| » Starters: Lefty Grove vs Johnny Broaca | Second | 4½ out |
| Tuesday, June 2 |
| » Defeated Indians (24-18), 14-6 | Fenway Park (17-7) | 27-18 | |
| » Starters: Oral Hildebrand vs Johnny Marcum | Second | 3½ out |
| Wednesday, June 3 |
| » Defeated Indians (24-19), 6-2 | Fenway Park (18-7) | 28-18 | Won 2 |
| » Starters: Johnny Allen vs Wes Ferrell | Second | 3½ out |
| Thursday, June 4 |
| » Defeated Indians (24-20), 4-3 | Fenway Park (19-7) | 29-18 | Won 3 |
| » Starters: George Blaeholder vs Lefty Grove | Second | 2½ out |
| Friday, June 5 |
| » Defeated White Sox (21-23), 8-6 | Fenway Park (20-7) | 30-18 | Won 4 |
| » Starters: Sugar Cain vs Jack Wilson | Second | 2½ out |
| Saturday, June 6 |
| » Defeated White Sox (21-24), 10-6 | Fenway Park (21-7) | 31-18 | Won 5 |
| » Starters: Vern Kennedy vs Jim Henry | Second | 1½ out |
| Sunday, June 7 |
| » Lost to White Sox (22-24), 13-5 | Fenway Park (21-8) | 31-19 | |
| » Starters: Ted Lyons vs Wes Ferrell | Second | 2½ out |
| Monday, June 8 |
| » Defeated Tigers (27-24), 6-3 | Fenway Park (22-8) | 32-19 | |
| » Starters: Tommy Bridges vs Lefty Grove | Second | 3 out |
| » Lost to Tigers (28-24), 12-7 | Fenway Park (22-9) | 32-20 | |
| » Starters: Elden Auker vs Fritz Ostermueller | Second | 3 out |
| Tuesday, June 9 |
| » Lost to Tigers (29-24), 8-4 | Fenway Park (22-10) | 32-21 | Lost 2 |
| » Starters: Vic Sorrell vs Rube Walberg | Second | 3 out |
| Wednesday, June 10 |
| » Defeated Tigers (29-25), 4-3 | Fenway Park (23-10) | 33-21 | |
| » Starters: Red Phillips vs Wes Ferrell | Second | 2½ out |
| Thursday, June 11 |
| » Defeated Browns (16-35), 7-5 | Fenway Park (24-10) | 34-21 | Won 2 |
| » Starters: Tommy Thomas vs Jim Henry | Second | 2½ out |
| Tuesday, June 16 |
| » Lost to White Sox (26-27), 4-2 | Comiskey Park I (3-1) | 34-22 | |
| » Starters: Lefty Grove vs Sugar Cain | Second | 3 out |
| Wednesday, June 17 |
| » Defeated White Sox (26-28), 9-4 | Comiskey Park I (4-1) | 35-22 | |
| » Starters: Wes Ferrell vs Ted Lyons | Second | 3½ out |
| Thursday, June 18 |
| » Lost to White Sox (27-28), 1-0 | Comiskey Park I (4-2) | 35-23 | |
| » Starters: Johnny Marcum vs John Whitehead | Second | 4½ out |
| Saturday, June 20 |
| » Lost to Browns (19-36), 7-5 | Sportsman's Park III (1-2) | 35-24 | Lost 2 |
| » Starters: Lefty Grove vs Tommy Thomas | Second | 5 out |
| Sunday, June 21 |
| » Defeated Browns (19-37), 3-0 | Sportsman's Park III (2-2) | 36-24 | |
| » Starters: Wes Ferrell vs Ivy Andrews | Second | 4½ out |
| » Lost to Browns (20-37), 6-3 | Sportsman's Park III (2-3) | 36-25 | |
| » Starters: Jack Wilson vs Chief Hogsett | Second | 4½ out |
| Monday, June 22 |
| » Lost to Tigers (32-31), 8-7 | Tiger Stadium (2-2) | 36-26 | Lost 2 |
| » Starters: Johnny Marcum vs Red Phillips | Second | 5½ out |
| Tuesday, June 23 |
| » Defeated Tigers (32-32), 7-6 | Tiger Stadium (3-2) | 37-26 | |
| » Starters: Lefty Grove vs Elden Auker | Second | 4½ out |
| Wednesday, June 24 |
| » Lost to Tigers (33-32), 7-6 | Tiger Stadium (3-3) | 37-27 | |
| » Starters: Wes Ferrell vs Tommy Bridges | Second | 5½ out |
| Thursday, June 25 |
| » Defeated Indians (33-32), 9-4 | League Park II (1-2) | 38-27 | |
| » Starters: Fritz Ostermueller vs Lloyd Brown | Second | 5½ out |
| Friday, June 26 |
| » Lost to Indians (34-32), 8-7 | League Park II (1-3) | 38-28 | |
| » Starters: Jack Wilson vs Denny Galehouse | Second | 6 out |
| Saturday, June 27 |
| » Lost to Indians (35-32), 14-5 | League Park II (1-4) | 38-29 | Lost 2 |
| » Starters: Wes Ferrell vs Johnny Allen | Second | 7 out |
| » Major-league debuts: Roy Weatherly (Indians) Emerson Dickman (Red Sox) |
| Sunday, June 28 |
| » Lost to Indians (36-32), 11-3 | Cleveland Stadium (0-1) | 38-30 | Lost 3 |
| » Starters: Fritz Ostermueller vs George Blaeholder | Second | 7½ out |
| Tuesday, June 30 |
| » Lost to Yankees (46-22), 10-5 | Yankee Stadium (1-3) | 38-31 | Lost 4 |
| » Starters: Lefty Grove vs Lefty Gomez | Second | 9½ out |
| » Lost to Yankees (47-22), 6-3 | Yankee Stadium (1-4) | 38-32 | Lost 5 |
| » Starters: Johnny Marcum vs Bump Hadley | Second | 9½ out |
| Wednesday, July 1 |
| » Lost to Yankees (48-22), 5-0 | Yankee Stadium (1-5) | 38-33 | Lost 6 |
| » Starters: Wes Ferrell vs Red Ruffing | Third | 10½ out |
| Thursday, July 2 |
| » Lost to Yankees (49-22), 8-7 | Yankee Stadium (1-6) | 38-34 | Lost 7 |
| » Starters: Jack Wilson vs Monte Pearson | Fifth | 11½ out |
| Saturday, July 4 |
| » Defeated Athletics (24-45), 1-0 | Fenway Park (25-10) | 39-34 | |
| » Starters: Herman Fink vs Lefty Grove | Third | 11½ out |
| » Defeated Athletics (24-46), 5-4 | Fenway Park (26-10) | 40-34 | Won 2 |
| » Starters: Harry Kelley vs Johnny Marcum | Third | 11½ out |
| Sunday, July 5 |
| » Defeated Athletics (24-47), 16-2 | Fenway Park (27-10) | 41-34 | Won 3 |
| » Starters: Pete Naktenis vs Wes Ferrell | Third | 10 out |
| » Defeated Athletics (24-48), 8-2 | Fenway Park (28-10) | 42-34 | Won 4 |
| » Starters: Buck Ross vs Jim Henry | Third | 10 out |
| Thursday, July 9 |
| » Defeated White Sox (35-39), 7-2 | Fenway Park (29-10) | 43-34 | Won 5 |
| » Starters: John Whitehead vs Wes Ferrell | Third | 9 out |
| Friday, July 10 |
| » Lost to White Sox (36-39), 8-2 | Fenway Park (29-11) | 43-35 | |
| » Starters: Vern Kennedy vs Johnny Marcum | Third | 10 out |
| Saturday, July 11 |
| » Lost to White Sox (37-39), 9-1 | Fenway Park (29-12) | 43-36 | Lost 2 |
| » Starters: Sugar Cain vs Jack Wilson | Third | 10 out |
| Sunday, July 12 |
| » Lost to Indians (42-38), 5-2 | Fenway Park (29-13) | 43-37 | Lost 3 |
| » Starters: Johnny Allen vs Lefty Grove | Third | 10½ out |
| Monday, July 13 |
| » Lost to Indians (43-38), 11-3 | Fenway Park (29-14) | 43-38 | Lost 4 |
| » Starters: George Blaeholder vs Fritz Ostermueller | Fourth | 10½ out |
| Tuesday, July 14 |
| » Lost to Indians (44-38), 5-1 | Fenway Park (29-15) | 43-39 | Lost 5 |
| » Starters: Oral Hildebrand vs Wes Ferrell | Fifth | 11 out |
| Wednesday, July 15 |
| » Defeated Browns (24-53), 11-3 | Fenway Park (30-15) | 44-39 | |
| » Starters: Jack Knott vs Johnny Marcum | Fifth | 10 out |
| » Defeated Browns (24-54), 9-1 | Fenway Park (31-15) | 45-39 | Won 2 |
| » Starters: Roy Mahaffey vs Fritz Ostermueller | Fifth | 10 out |
| Thursday, July 16 |
| » Lost to Browns (25-54), 6-3 | Fenway Park (31-16) | 45-40 | |
| » Starters: Earl Caldwell vs Lefty Grove | Fourth | 10½ out |
| » Defeated Browns (25-55), 5-4 | Fenway Park (32-16) | 46-40 | |
| » Starters: Tommy Thomas vs Jim Henry | Fourth | 10½ out |
| Friday, July 17 |
| » Defeated Browns (25-56), 2-1 | Fenway Park (33-16) | 47-40 | Won 2 |
| » Starters: Ivy Andrews vs Wes Ferrell | Third | 10½ out |
| Saturday, July 18 |
| » Lost to Tigers (46-39), 6-5 | Fenway Park (33-17) | 47-41 | |
| » Starters: Elden Auker vs Fritz Ostermueller | Fourth | 11 out |
| Sunday, July 19 |
| » Defeated Tigers (46-40), 12-3 | Fenway Park (34-17) | 48-41 | |
| » Starters: Schoolboy Rowe vs Johnny Marcum | Third | 10½ out |
| Tuesday, July 21 |
| » Lost to Indians (50-39), 6-5 | League Park II (1-5) | 48-42 | |
| » Starters: Lefty Grove vs Mel Harder | Fourth | 10½ out |
| Wednesday, July 22 |
| » Lost to Indians (51-39), 8-3 | League Park II (1-6) | 48-43 | Lost 2 |
| » Starters: Wes Ferrell vs Johnny Allen | Fifth | 10½ out |
| Thursday, July 23 |
| » Defeated Indians (51-40), 9-8 | League Park II (2-6) | 49-43 | |
| » Starters: Fritz Ostermueller vs Oral Hildebrand | Fifth | 10½ out |
| Friday, July 24 |
| » Defeated Tigers (49-42), 7-4 | Tiger Stadium (4-3) | 50-43 | Won 2 |
| » Starters: Johnny Marcum vs Vic Sorrell | Fourth | 10 out |
| Saturday, July 25 |
| » Defeated Tigers (49-43), 18-3 | Tiger Stadium (5-3) | 51-43 | Won 3 |
| » Starters: Lefty Grove vs Tommy Bridges | Third | 10 out |
| Sunday, July 26 |
| » Defeated Tigers (49-44), 10-3 | Tiger Stadium (6-3) | 52-43 | Won 4 |
| » Starters: Wes Ferrell vs Elden Auker | Third | 10½ out |
| Monday, July 27 |
| » Lost to Browns (31-62), 7-5 | Sportsman's Park III (2-4) | 52-44 | |
| » Starters: Jim Henry vs Ivy Andrews | Third | 10½ out |
| Future Red Sox Don Lock is born in Wichita, KS. |
| Tuesday, July 28 |
| » Defeated Browns (31-63), 5-2 | Sportsman's Park III (3-4) | 53-44 | |
| » Starters: Johnny Marcum vs Earl Caldwell | Third | 10½ out |
| Wednesday, July 29 |
| » Lost to Browns (32-63), 9-3 | Sportsman's Park III (3-5) | 53-45 | |
| » Starters: Fritz Ostermueller vs Chief Hogsett | Third | 11½ out |
| Thursday, July 30 |
| » Lost to Browns (33-63), 4-3 | Sportsman's Park III (3-6) | 53-46 | Lost 2 |
| » Starters: Wes Ferrell vs Tommy Thomas | Third | 11½ out |
| Friday, July 31 |
| » Defeated White Sox (51-46), 7-3 | Comiskey Park I (5-2) | 54-46 | |
| » Starters: Lefty Grove vs Ted Lyons | Third | 11½ out |
| Saturday, August 1 |
| » Lost to White Sox (52-46), 3-0 | Comiskey Park I (5-3) | 54-47 | |
| » Starters: Johnny Marcum vs Bill Dietrich | Third | 12½ out |
| Sunday, August 2 |
| » Lost to White Sox (53-46), 9-1 | Comiskey Park I (5-4) | 54-48 | Lost 2 |
| » Starters: Jack Russell vs Sugar Cain | Fifth | 13½ out |
| » Lost to White Sox (54-46), 12-11 | Comiskey Park I (5-5) | 54-49 | Lost 3 |
| » Starters: Wes Ferrell vs Vern Kennedy | Fifth | 13½ out |
| Tuesday, August 4 |
| » Lost to Yankees (67-34), 4-2 | Fenway Park (34-18) | 54-50 | Lost 4 |
| » Starters: Red Ruffing vs Lefty Grove | Fifth | 14½ out |
| Wednesday, August 5 |
| » Lost to Yankees (68-34), 7-2 | Fenway Park (34-19) | 54-51 | Lost 5 |
| » Starters: Johnny Broaca vs Johnny Marcum | Fifth | 15½ out |
| Friday, August 7 |
| » Lost to Senators (51-53), 3-2 | Griffith Stadium (1-3) | 54-52 | Lost 6 |
| » Starters: Wes Ferrell vs Earl Whitehill | Fifth | 16 out |
| Saturday, August 8 |
| » Lost to Senators (52-53), 2-0 | Griffith Stadium (1-4) | 54-53 | Lost 7 |
| » Starters: Jack Russell vs Pete Appleton | Fifth | 17 out |
| Sunday, August 9 |
| » Defeated Senators (52-54), 8-2 | Griffith Stadium (2-4) | 55-53 | |
| » Starters: Fritz Ostermueller vs Bobo Newsom | Fifth | 17½ out |
| Tuesday, August 11 |
| » Defeated Athletics (36-71), 4-1 | Fenway Park (35-19) | 56-53 | Won 2 |
| » Starters: Herman Fink vs Johnny Marcum | Fifth | 16 out |
| Future Red Sox Bill Monboquette is born in Medford, MA. |
| Wednesday, August 12 |
| » Defeated Athletics (36-72), 6-4 | Fenway Park (36-19) | 57-53 | Won 3 |
| » Starters: Hod Lisenbee vs Wes Ferrell | Fifth | 16½ out |
| » Lost to Athletics (37-72), 6-0 | Fenway Park (36-20) | 57-54 | |
| » Starters: Harry Kelley vs Mike Meola | Fifth | 16½ out |
| Friday, August 14 |
| » Defeated Senators (54-56), 9-0 | Fenway Park (37-20) | 58-54 | |
| » Starters: Pete Appleton vs Lefty Grove | Fifth | 15½ out |
| Saturday, August 15 |
| » Lost to Senators (55-56), 11-5 | Fenway Park (37-21) | 58-55 | |
| » Starters: Jimmie DeShong vs Fritz Ostermueller | Fifth | 16½ out |
| Sunday, August 16 |
| » Lost to Senators (56-56), 7-6 | Fenway Park (37-22) | 58-56 | Lost 2 |
| » Starters: Joe Cascarella vs Wes Ferrell | Fifth | 17½ out |
| » Lost to Senators (57-56), 3-2 | Fenway Park (37-23) | 58-57 | Lost 3 |
| » Starters: Bobo Newsom vs Johnny Marcum | Fifth | 17½ out |
| Tuesday, August 18 |
| » Defeated Athletics (39-75), 6-2 | Shibe Park (3-3) | 59-57 | |
| » Starters: Lefty Grove vs Gordon Rhodes | Sixth | 16 out |
| Wednesday, August 19 |
| » Lost to Athletics (40-75), 5-4 | Shibe Park (3-4) | 59-58 | |
| » Starters: Jack Wilson vs Buck Ross | Sixth | 17½ out |
| » Lost to Athletics (41-75), 7-2 | Shibe Park (3-5) | 59-59 | Lost 2 |
| » Starters: Fritz Ostermueller vs Harry Kelley | Sixth | 17½ out |
| Friday, August 21 |
| » Lost to Yankees (76-40), 4-1 | Yankee Stadium (1-7) | 59-60 | Lost 3 |
| » Starters: Wes Ferrell vs Monte Pearson | Sixth | 18½ out |
| Saturday, August 22 |
| » Lost to Yankees (77-40), 3-2 | Yankee Stadium (1-8) | 59-61 | Lost 4 |
| » Starters: Lefty Grove vs Johnny Broaca | Sixth | 19½ out |
| Sunday, August 23 |
| » Lost to Yankees (78-40), 5-3 | Yankee Stadium (1-9) | 59-62 | Lost 5 |
| » Starters: Johnny Marcum vs Red Ruffing | Sixth | 19½ out |
| » Defeated Yankees (78-41), 6-3 | Yankee Stadium (2-9) | 60-62 | |
| » Starters: Fritz Ostermueller vs Bump Hadley | Sixth | 19½ out |
| Tuesday, August 25 |
| » Lost to Tigers (66-57), 5-0 | Fenway Park (37-24) | 60-63 | |
| » Starters: Schoolboy Rowe vs Jack Wilson | Sixth | 20½ out |
| Wednesday, August 26 |
| » Defeated Tigers (66-58), 7-0 | Fenway Park (38-24) | 61-63 | |
| » Starters: Elden Auker vs Wes Ferrell | Sixth | 19½ out |
| Thursday, August 27 |
| » Lost to Tigers (67-58), 4-2 | Fenway Park (38-25) | 61-64 | |
| » Starters: Tommy Bridges vs Lefty Grove | Sixth | 20½ out |
| Friday, August 28 |
| » Lost to Browns (46-78), 8-1 | Fenway Park (38-26) | 61-65 | Lost 2 |
| » Starters: Earl Caldwell vs Johnny Marcum | Sixth | 21½ out |
| » Defeated Browns (46-79), 2-1 | Fenway Park (39-26) | 62-65 | |
| » Starters: Jack Knott vs Fritz Ostermueller | Sixth | 21½ out |
| Sunday, August 30 |
| » Defeated Indians (69-57), 3-2 | Fenway Park (40-26) | 63-65 | Won 2 |
| » Starters: Oral Hildebrand vs Wes Ferrell | Sixth | 22 out |
| » Defeated Indians (69-58), 5-1 | Fenway Park (41-26) | 64-65 | Won 3 |
| » Starters: Bob Feller vs Rube Walberg | Sixth | 22 out |
| Tuesday, September 1 |
| » Defeated Indians (69-59), 4-1 | Fenway Park (42-26) | 65-65 | Won 4 |
| » Starters: Mel Harder vs Lefty Grove | Fifth | 22 out |
| Thursday, September 3 |
| » Lost to White Sox (68-62), 3-2 | Fenway Park (42-27) | 65-66 | |
| » Starters: John Whitehead vs Wes Ferrell | Fifth | 22 out |
| » Defeated White Sox (68-63), 5-0 | Fenway Park (43-27) | 66-66 | |
| » Starters: Sugar Cain vs Johnny Marcum | Fifth | 22 out |
| Friday, September 4 |
| » Lost to Yankees (88-43), 9-6 | Fenway Park (43-28) | 66-67 | |
| » Starters: Johnny Murphy vs Fritz Ostermueller | Sixth | 23 out |
| Saturday, September 5 |
| » Defeated Yankees (88-44), 3-2 | Fenway Park (44-28) | 67-67 | |
| » Starters: Bump Hadley vs Rube Walberg | Sixth | 22 out |
| » Tied Yankees, 7-7 | Fenway Park (44-28) | 67-67 | |
| » Starters: Monte Pearson vs Mike Meola | Sixth | 22 out |
| Sunday, September 6 |
| » Defeated Yankees (88-45), 14-5 | Fenway Park (45-28) | 68-67 | Won 2 |
| » Starters: Johnny Broaca vs Wes Ferrell | Fifth | 20 out |
| » Defeated Yankees (88-46), 4-2 | Fenway Park (46-28) | 69-67 | Won 3 |
| » Starters: Jumbo Brown vs Lefty Grove | Fifth | 20 out |
| Monday, September 7 |
| » Lost to Senators (72-64), 6-4 | Griffith Stadium (2-5) | 69-68 | |
| » Starters: Jack Wilson vs Jimmie DeShong | Fifth | 21 out |
| » Defeated Senators (72-65), 6-5 | Griffith Stadium (3-5) | 70-68 | |
| » Starters: Fritz Ostermueller vs Bobo Newsom | Fifth | 21 out |
| Wednesday, September 9 |
| » Lost to White Sox (74-64), 3-2 | Comiskey Park I (5-6) | 70-69 | |
| » Starters: Rube Walberg vs Vern Kennedy | Sixth | 22½ out |
| » Major-league debuts: Fabian Gaffke (Red Sox) |
| Friday, September 11 |
| » Defeated Browns (49-86), 6-2 | Sportsman's Park III (4-6) | 71-69 | |
| » Starters: Wes Ferrell vs Earl Caldwell | Sixth | 22 out |
| Saturday, September 12 |
| » Lost to Browns (50-86), 6-4 | Sportsman's Park III (4-7) | 71-70 | |
| » Starters: Fritz Ostermueller vs Tommy Thomas | Sixth | 22½ out |
| » Lost to Browns (51-86), 3-2 | Sportsman's Park III (4-8) | 71-71 | Lost 2 |
| » Starters: Mike Meola vs Earl Caldwell | Sixth | 22½ out |
| Sunday, September 13 |
| » Defeated Tigers (74-68), 7-4 | Tiger Stadium (7-3) | 72-71 | |
| » Starters: Rube Walberg vs Red Phillips | Fifth | 23 out |
| Monday, September 14 |
| » Lost to Tigers (75-68), 1-0 | Tiger Stadium (7-4) | 72-72 | |
| » Starters: Jack Wilson vs Tommy Bridges | Fifth | 23½ out |
| Future Red Sox Stan Williams is born in Enfield, NH. |
| Tuesday, September 15 |
| » Lost to Indians (75-68), 13-2 | League Park II (2-7) | 72-73 | Lost 2 |
| » Starters: Jennings Poindexter vs Johnny Allen | Sixth | 24½ out |
| Wednesday, September 16 |
| » Lost to Indians (76-68), 13-3 | League Park II (2-8) | 72-74 | Lost 3 |
| » Starters: Ted Olson vs Bill Zuber | Fifth | 25 out |
| » Major-league debuts: Bill Zuber (Indians) |
| Saturday, September 19 |
| » Defeated Athletics (49-96), 5-1 | Shibe Park (4-5) | 73-74 | |
| » Starters: Wes Ferrell vs Buck Ross | Sixth | 25 out |
| Sunday, September 20 |
| » Lost to Athletics (50-96), 3-1 | Shibe Park (4-6) | 73-75 | |
| » Starters: Lefty Grove vs Herman Fink | Sixth | 26 out |
| » Lost to Athletics (51-96), 5-4 | Shibe Park (4-7) | 73-76 | Lost 2 |
| » Starters: Ted Olson vs Eddie Smith | Sixth | 26 out |
| Tuesday, September 22 |
| » Lost to Senators (79-70), 4-0 | Griffith Stadium (3-6) | 73-77 | Lost 3 |
| » Starters: Rube Walberg vs Joe Cascarella | Sixth | 27 out |
| Wednesday, September 23 |
| » Lost to Senators (80-70), 3-2 | Griffith Stadium (3-7) | 73-78 | Lost 4 |
| » Starters: Jennings Poindexter vs Pete Appleton | Sixth | 28 out |
| Friday, September 25 |
| » Lost to Senators (81-70), 9-3 | Griffith Stadium (3-8) | 73-79 | Lost 5 |
| » Starters: Jim Henry vs Jimmie DeShong | Sixth | 28½ out |
| Sunday, September 27 |
| » Lost to Athletics (53-99), 8-4 | Fenway Park (46-29) | 73-80 | Lost 6 |
| » Starters: George Turbeville vs Jennings Poindexter | Sixth | 28½ out |
| » Defeated Athletics (53-100), 5-4 | Fenway Park (47-29) | 74-80 | |
| » Starters: Fred Archer vs Ted Olson | Sixth | 28½ out |
| Saturday, October 3 |
| Future Red Sox Jack Lamabe is born in Farmingdale, NY. |
| Tuesday, October 27 |
| Future Red Sox Lee Stange is born in Chicago, IL. |
| Saturday, October 31 |
| Former Red Sox Deacon McGuire dies in Duck Lake, MI at the age of 73. |
| Tuesday, November 17 |
| Future Red Sox Gary Bell is born in San Antonio, TX. |
| Friday, November 20 |
| Future Red Sox Jay Ritchie is born in Salisbury, NC. |
| Friday, December 11 |
| Former Red Sox Myron Grimshaw dies in Canajoharie, NY at the age of 62. |
| Thursday, December 17 |
| Future Red Sox Jerry Adair is born in Sand Springs, OK. |
Game information provided by Retrosheet (www.retrosheet.org) |
