| Friday, January 24 |
| Future Indian Dick Stigman is born in Nimrod, MN. |
| Thursday, February 20 |
| Future Indian Wynn Hawkins is born in East Palestine, OH. |
| Thursday, March 12 |
| Future Indian Ray Barker is born in Martinsburg, WV. |
| Tuesday, April 14 |
| » Lost to Tigers (1-0), 3-0 | League Park II (0-1) | 0-1 | |
| » Starters: Schoolboy Rowe vs Mel Harder | Second | 1 out |
| Wednesday, April 15 |
| » Defeated Tigers (1-1), 14-7 | League Park II (1-1) | 1-1 | |
| » Starters: Tommy Bridges vs Willis Hudlin | Third | 1 out |
| Friday, April 17 |
| » Defeated Browns (0-3), 13-10 | Sportsman's Park III (1-0) | 2-1 | Won 2 |
| » Starters: Johnny Allen vs Roy Mahaffey | Third | 1 out |
| Saturday, April 18 |
| » Defeated Browns (0-4), 7-2 | Sportsman's Park III (2-0) | 3-1 | Won 3 |
| » Starters: Lloyd Brown vs Russ VanAtta | Third | ½ out |
| Sunday, April 19 |
| » Defeated Browns (0-5), 13-6 | Sportsman's Park III (3-0) | 4-1 | Won 4 |
| » Starters: Mel Harder vs Ivy Andrews | First | -- |
| Monday, April 20 |
| » Lost to White Sox (4-1), 5-1 | Comiskey Park I (0-1) | 4-2 | |
| » Starters: Oral Hildebrand vs Vern Kennedy | Third | ½ out |
| Wednesday, April 22 |
| » Major-league debuts: Jake Wade (Tigers) |
| Thursday, April 23 |
| » Defeated White Sox (4-2), 6-0 | League Park II (2-1) | 5-2 | |
| » Starters: John Whitehead vs Johnny Allen | First | -- |
| Friday, April 24 |
| » Defeated White Sox (4-3), 6-2 | League Park II (3-1) | 6-2 | Won 2 |
| » Starters: Monty Stratton vs Mel Harder | First | -- |
| Saturday, April 25 |
| » Lost to Browns (3-7), 6-3 | League Park II (3-2) | 6-3 | |
| » Starters: Roy Mahaffey vs Willis Hudlin | Second | 1½ out |
| » Major-league debuts: Jim Gleeson (Indians) |
| Sunday, April 26 |
| » Defeated Browns (3-8), 8-7 | Cleveland Stadium (1-0) | 7-3 | |
| » Starters: Sugar Cain vs Oral Hildebrand | First | -- |
| Monday, April 27 |
| » Defeated Browns (3-9), 2-1 | League Park II (4-2) | 8-3 | Won 2 |
| » Starters: Russ VanAtta vs George Blaeholder | First | -- |
| Tuesday, April 28 |
| » Lost to Yankees (8-5), 2-0 | Yankee Stadium (0-1) | 8-4 | |
| » Starters: Lloyd Brown vs Red Ruffing | First | -- |
| Wednesday, April 29 |
| » Lost to Yankees (9-5), 6-1 | Yankee Stadium (0-2) | 8-5 | Lost 2 |
| » Starters: Thornton Lee vs Lefty Gomez | Third | 1 out |
| Thursday, April 30 |
| » Lost to Yankees (10-5), 8-1 | Yankee Stadium (0-3) | 8-6 | Lost 3 |
| » Starters: Johnny Allen vs Monte Pearson | Third | 2 out |
| » Major-league debuts: Al Milnar (Indians) |
| Friday, May 1 |
| » Lost to Red Sox (12-5), 6-0 | Fenway Park (0-1) | 8-7 | Lost 4 |
| » Starters: Mel Harder vs Lefty Grove | Fifth | 3 out |
| Saturday, May 2 |
| » Defeated Red Sox (12-6), 7-3 | Fenway Park (1-1) | 9-7 | |
| » Starters: Oral Hildebrand vs Fritz Ostermueller | Fifth | 2 out |
| Sunday, May 3 |
| » Defeated Senators (11-9), 3-0 | Griffith Stadium (1-0) | 10-7 | Won 2 |
| » Starters: George Blaeholder vs Bobo Newsom | Third | 2 out |
| Monday, May 4 |
| » Defeated Senators (11-10), 6-3 | Griffith Stadium (2-0) | 11-7 | Won 3 |
| » Starters: Lloyd Brown vs Pete Appleton | Third | 1½ out |
| Tuesday, May 5 |
| » Defeated Senators (11-11), 6-4 | Griffith Stadium (3-0) | 12-7 | Won 4 |
| » Starters: Thornton Lee vs Jimmie DeShong | Third | 1½ out |
| Wednesday, May 6 |
| » Defeated Athletics (7-12), 7-1 | Shibe Park (1-0) | 13-7 | Won 5 |
| » Starters: Johnny Allen vs George Turbeville | Third | 1½ out |
| Thursday, May 7 |
| » Defeated Athletics (7-13), 4-3 | Shibe Park (2-0) | 14-7 | Won 6 |
| » Starters: Mel Harder vs Buck Ross | Third | 1½ out |
| Saturday, May 9 |
| » Lost to Tigers (10-10), 4-3 | Tiger Stadium (0-1) | 14-8 | |
| » Starters: Oral Hildebrand vs Schoolboy Rowe | Third | 2 out |
| Sunday, May 10 |
| » Defeated Tigers (10-11), 9-7 | Tiger Stadium (1-1) | 15-8 | |
| » Starters: George Blaeholder vs Elden Auker | Third | 1½ out |
| Monday, May 11 |
| » Lost to Tigers (11-11), 8-3 | Tiger Stadium (1-2) | 15-9 | |
| » Starters: Johnny Allen vs Tommy Bridges | Third | 2 out |
| Thursday, May 14 |
| » Lost to Athletics (9-15), 4-0 | League Park II (4-3) | 15-10 | Lost 2 |
| » Starters: Gordon Rhodes vs Lloyd Brown | Third | 3 out |
| Future Indian Dick Howser is born in Miami, FL. |
| Friday, May 15 |
| » Defeated Red Sox (19-10), 7-2 | League Park II (5-3) | 16-10 | |
| » Starters: Johnny Marcum vs Oral Hildebrand | Third | 2 out |
| Saturday, May 16 |
| » Defeated Red Sox (19-11), 10-3 | League Park II (6-3) | 17-10 | Won 2 |
| » Starters: Wes Ferrell vs Mel Harder | Third | 2 out |
| Sunday, May 17 |
| » Lost to Yankees (21-9), 8-4 | Cleveland Stadium (1-1) | 17-11 | |
| » Starters: Lefty Gomez vs Johnny Allen | Third | 3 out |
| Tuesday, May 19 |
| » Lost to Yankees (22-9), 10-4 | League Park II (6-4) | 17-12 | Lost 2 |
| » Starters: Monte Pearson vs George Blaeholder | Third | 4 out |
| Wednesday, May 20 |
| » Lost to Senators (16-18), 7-6 | League Park II (6-5) | 17-13 | Lost 3 |
| » Starters: Jimmie DeShong vs Thornton Lee | Third | 4 out |
| Thursday, May 21 |
| » Lost to Senators (17-18), 7-4 | League Park II (6-6) | 17-14 | Lost 4 |
| » Starters: Earl Whitehill vs Oral Hildebrand | Fourth | 4 out |
| Future Indian Barry Latman is born in Los Angeles, CA. |
| Friday, May 22 |
| » Lost to Tigers (19-14), 13-10 | League Park II (6-7) | 17-15 | Lost 5 |
| » Starters: Elden Auker vs Mel Harder | Fourth | 4½ out |
| Saturday, May 23 |
| » Lost to Tigers (20-14), 13-5 | League Park II (6-8) | 17-16 | Lost 6 |
| » Starters: Tommy Bridges vs Johnny Allen | Fourth | 5½ out |
| » Defeated Tigers (20-15), 4-3 | League Park II (7-8) | 18-16 | |
| » Starters: Joe Sullivan vs George Blaeholder | Fourth | 5½ out |
| Sunday, May 24 |
| » Defeated Tigers (20-16), 7-0 | Cleveland Stadium (2-1) | 19-16 | Won 2 |
| » Starters: Schoolboy Rowe vs Lloyd Brown | Fourth | 5½ out |
| Tuesday, May 26 |
| » Lost to Browns (9-28), 8-5 | League Park II (7-9) | 19-17 | |
| » Starters: Chief Hogsett vs Mel Harder | Fifth | 5 out |
| Wednesday, May 27 |
| » Defeated Browns (9-29), 12-2 | League Park II (8-9) | 20-17 | |
| » Starters: Roy Mahaffey vs Oral Hildebrand | Fourth | 5 out |
| Thursday, May 28 |
| » Defeated Browns (9-30), 6-5 | League Park II (9-9) | 21-17 | Won 2 |
| » Starters: Jack Knott vs Johnny Allen | Third | 5 out |
| Saturday, May 30 |
| » Defeated White Sox (19-19), 4-3 | League Park II (10-9) | 22-17 | Won 3 |
| » Starters: John Whitehead vs Lloyd Brown | Third | 5 out |
| » Defeated White Sox (19-20), 11-3 | League Park II (11-9) | 23-17 | Won 4 |
| » Starters: Sugar Cain vs George Blaeholder | Third | 5 out |
| Sunday, May 31 |
| » Defeated White Sox (19-21), 7-5 | Cleveland Stadium (3-1) | 24-17 | Won 5 |
| » Starters: Vern Kennedy vs Mel Harder | Third | 5 out |
| Tuesday, June 2 |
| » Lost to Red Sox (27-18), 14-6 | Fenway Park (1-2) | 24-18 | |
| » Starters: Oral Hildebrand vs Johnny Marcum | Third | 5 out |
| Wednesday, June 3 |
| » Lost to Red Sox (28-18), 6-2 | Fenway Park (1-3) | 24-19 | Lost 2 |
| » Starters: Johnny Allen vs Wes Ferrell | Third | 6 out |
| Thursday, June 4 |
| » Lost to Red Sox (29-18), 4-3 | Fenway Park (1-4) | 24-20 | Lost 3 |
| » Starters: George Blaeholder vs Lefty Grove | Third | 6 out |
| Friday, June 5 |
| » Lost to Yankees (32-15), 4-3 | Yankee Stadium (0-4) | 24-21 | Lost 4 |
| » Starters: Lloyd Brown vs Lefty Gomez | Third | 7 out |
| Saturday, June 6 |
| » Defeated Yankees (32-16), 4-2 | Yankee Stadium (1-4) | 25-21 | |
| » Starters: Mel Harder vs Monte Pearson | Third | 6 out |
| Sunday, June 7 |
| » Lost to Yankees (33-16), 5-4 | Yankee Stadium (1-5) | 25-22 | |
| » Starters: Oral Hildebrand vs Red Ruffing | Fourth | 7 out |
| Tuesday, June 9 |
| » Lost to Senators (26-25), 2-1 | Griffith Stadium (3-1) | 25-23 | Lost 2 |
| » Starters: Johnny Allen vs Pete Appleton | Fourth | 7½ out |
| Wednesday, June 10 |
| » Defeated Senators (26-26), 10-2 | Griffith Stadium (4-1) | 26-23 | |
| » Starters: George Blaeholder vs Earl Whitehill | Fourth | 7 out |
| Thursday, June 11 |
| » Lost to Athletics (17-32), 5-2 | Shibe Park (2-1) | 26-24 | |
| » Starters: Mel Harder vs Harry Kelley | Fourth | 8 out |
| Saturday, June 13 |
| » Lost to Athletics (18-32), 7-3 | Shibe Park (2-2) | 26-25 | Lost 2 |
| » Starters: Lloyd Brown vs Gordon Rhodes | Third | 8½ out |
| » Defeated Athletics (18-33), 19-1 | Shibe Park (3-2) | 27-25 | |
| » Starters: Johnny Allen vs Herman Fink | Third | 8½ out |
| Sunday, June 14 |
| » Lost to Athletics (19-33), 8-6 | Shibe Park (3-3) | 27-26 | |
| » Starters: Oral Hildebrand vs Buck Ross | Fourth | 9 out |
| Tuesday, June 16 |
| » Defeated Yankees (36-18), 8-4 | League Park II (12-9) | 28-26 | |
| » Starters: Lefty Gomez vs George Blaeholder | Third | 8 out |
| Wednesday, June 17 |
| » Lost to Yankees (37-18), 15-4 | League Park II (12-10) | 28-27 | |
| » Starters: Red Ruffing vs Lloyd Brown | Fourth | 10 out |
| » Lost to Yankees (38-18), 12-2 | League Park II (12-11) | 28-28 | Lost 2 |
| » Starters: Monte Pearson vs Mel Harder | Fourth | 10 out |
| Thursday, June 18 |
| » Lost to Yankees (39-18), 6-5 | League Park II (12-12) | 28-29 | Lost 3 |
| » Starters: Bump Hadley vs Johnny Allen | Sixth | 11 out |
| Friday, June 19 |
| » Defeated Senators (31-29), 9-6 | League Park II (13-12) | 29-29 | |
| » Starters: Pete Appleton vs Thornton Lee | Fifth | 11 out |
| Saturday, June 20 |
| » Defeated Senators (31-30), 2-1 | League Park II (14-12) | 30-29 | Won 2 |
| » Starters: Joe Cascarella vs Mel Harder | Fourth | 10 out |
| Sunday, June 21 |
| » Defeated Senators (31-31), 8-3 | Cleveland Stadium (4-1) | 31-29 | Won 3 |
| » Starters: Earl Whitehill vs Denny Galehouse | Third | 9 out |
| Monday, June 22 |
| » Lost to Athletics (23-36), 4-3 | League Park II (14-13) | 31-30 | |
| » Starters: Gordon Rhodes vs Johnny Allen | Fourth | 10 out |
| Tuesday, June 23 |
| » Lost to Athletics (24-36), 8-6 | League Park II (14-14) | 31-31 | Lost 2 |
| » Starters: Buck Ross vs George Blaeholder | Fourth | 10 out |
| Wednesday, June 24 |
| » Defeated Athletics (24-37), 5-3 | League Park II (15-14) | 32-31 | |
| » Starters: Harry Kelley vs Mel Harder | Third | 9½ out |
| » Defeated Athletics (24-38), 14-2 | League Park II (16-14) | 33-31 | Won 2 |
| » Starters: Bill Dietrich vs Oral Hildebrand | Third | 9½ out |
| Thursday, June 25 |
| » Lost to Red Sox (38-27), 9-4 | League Park II (16-15) | 33-32 | |
| » Starters: Fritz Ostermueller vs Lloyd Brown | Fifth | 10½ out |
| Friday, June 26 |
| » Defeated Red Sox (38-28), 8-7 | League Park II (17-15) | 34-32 | |
| » Starters: Jack Wilson vs Denny Galehouse | Fourth | 10 out |
| Saturday, June 27 |
| » Defeated Red Sox (38-29), 14-5 | League Park II (18-15) | 35-32 | Won 2 |
| » Starters: Wes Ferrell vs Johnny Allen | Third | 10 out |
| » Major-league debuts: Roy Weatherly (Indians) Emerson Dickman (Red Sox) |
| Sunday, June 28 |
| » Defeated Red Sox (38-30), 11-3 | Cleveland Stadium (5-1) | 36-32 | Won 3 |
| » Starters: Fritz Ostermueller vs George Blaeholder | Third | 9½ out |
| Wednesday, July 1 |
| » Lost to Browns (22-42), 16-12 | Sportsman's Park III (3-1) | 36-33 | |
| » Starters: Oral Hildebrand vs Jack Knott | Fourth | 11½ out |
| » Tied Browns, 5-5 | Sportsman's Park III (3-1) | 36-33 | |
| » Starters: Mel Harder vs Earl Caldwell | Fourth | 11½ out |
| Thursday, July 2 |
| » Defeated Browns (22-43), 14-6 | Sportsman's Park III (4-1) | 37-33 | |
| » Starters: Lloyd Brown vs Roy Mahaffey | Fourth | 11 out |
| » Defeated Browns (22-44), 4-2 | Sportsman's Park III (5-1) | 38-33 | Won 2 |
| » Starters: Johnny Allen vs Ivy Andrews | Fourth | 11 out |
| Friday, July 3 |
| » Lost to White Sox (32-37), 6-5 | Comiskey Park I (0-2) | 38-34 | |
| » Starters: George Blaeholder vs Italo Chelini | Fourth | 11½ out |
| Saturday, July 4 |
| » Lost to White Sox (33-37), 9-2 | Comiskey Park I (0-3) | 38-35 | Lost 2 |
| » Starters: Thornton Lee vs Vern Kennedy | Fifth | 13½ out |
| » Lost to White Sox (34-37), 8-4 | Comiskey Park I (0-4) | 38-36 | Lost 3 |
| » Starters: Willis Hudlin vs Sugar Cain | Fifth | 13½ out |
| Sunday, July 5 |
| » Defeated White Sox (34-38), 11-4 | Comiskey Park I (1-4) | 39-36 | |
| » Starters: Mel Harder vs Clint Brown | Fifth | 13 out |
| » Lost to White Sox (35-38), 4-2 | Comiskey Park I (1-5) | 39-37 | |
| » Starters: Lloyd Brown vs John Whitehead | Fifth | 13 out |
| Thursday, July 9 |
| » Defeated Yankees (51-24), 11-4 | Yankee Stadium (2-5) | 40-37 | |
| » Starters: Johnny Allen vs Monte Pearson | Fifth | 12 out |
| Friday, July 10 |
| » Lost to Yankees (52-24), 18-0 | Yankee Stadium (2-6) | 40-38 | |
| » Starters: Lloyd Brown vs Red Ruffing | Fifth | 13 out |
| Saturday, July 11 |
| » Defeated Yankees (52-25), 10-2 | Yankee Stadium (3-6) | 41-38 | |
| » Starters: Mel Harder vs Lefty Gomez | Fifth | 12 out |
| Sunday, July 12 |
| » Defeated Red Sox (43-37), 5-2 | Fenway Park (2-4) | 42-38 | Won 2 |
| » Starters: Johnny Allen vs Lefty Grove | Fifth | 11½ out |
| Monday, July 13 |
| » Defeated Red Sox (43-38), 11-3 | Fenway Park (3-4) | 43-38 | Won 3 |
| » Starters: George Blaeholder vs Fritz Ostermueller | Fourth | 10½ out |
| Tuesday, July 14 |
| » Defeated Red Sox (43-39), 5-1 | Fenway Park (4-4) | 44-38 | Won 4 |
| » Starters: Oral Hildebrand vs Wes Ferrell | Fourth | 10 out |
| Wednesday, July 15 |
| » Defeated Athletics (28-51), 6-4 | Shibe Park (4-3) | 45-38 | Won 5 |
| » Starters: Mel Harder vs Gordon Rhodes | Third | 9½ out |
| Thursday, July 16 |
| » Defeated Athletics (28-52), 7-0 | Shibe Park (5-3) | 46-38 | Won 6 |
| » Starters: Johnny Allen vs Herman Fink | Second | 9½ out |
| Future Indian Eddie Fisher is born in Shreveport, LA. |
| Friday, July 17 |
| » Defeated Athletics (28-53), 5-1 | Shibe Park (6-3) | 47-38 | Won 7 |
| » Starters: Denny Galehouse vs Carl Doyle | Second | 9½ out |
| Saturday, July 18 |
| » Defeated Senators (44-41), 10-3 | Griffith Stadium (5-1) | 48-38 | Won 8 |
| » Starters: Lloyd Brown vs Bobo Newsom | Second | 9 out |
| Sunday, July 19 |
| » Defeated Senators (44-42), 11-3 | Griffith Stadium (6-1) | 49-38 | Won 9 |
| » Starters: Thornton Lee vs Joe Cascarella | Second | 9 out |
| » Lost to Senators (45-42), 9-5 | Griffith Stadium (6-2) | 49-39 | |
| » Starters: George Blaeholder vs Monte Weaver | Second | 9 out |
| » Major-league debuts: Bob Feller (Indians) |
| Tuesday, July 21 |
| » Defeated Red Sox (48-42), 6-5 | League Park II (19-15) | 50-39 | |
| » Starters: Lefty Grove vs Mel Harder | Second | 8 out |
| Wednesday, July 22 |
| » Defeated Red Sox (48-43), 8-3 | League Park II (20-15) | 51-39 | Won 2 |
| » Starters: Wes Ferrell vs Johnny Allen | Second | 7 out |
| Thursday, July 23 |
| » Lost to Red Sox (49-43), 9-8 | League Park II (20-16) | 51-40 | |
| » Starters: Fritz Ostermueller vs Oral Hildebrand | Second | 8 out |
| Friday, July 24 |
| » Defeated Athletics (29-61), 16-3 | League Park II (21-16) | 52-40 | |
| » Starters: Gordon Rhodes vs Denny Galehouse | Second | 7½ out |
| Saturday, July 25 |
| » Lost to Athletics (30-61), 15-12 | League Park II (21-17) | 52-41 | |
| » Starters: Carl Doyle vs George Blaeholder | Second | 8½ out |
| Sunday, July 26 |
| » Lost to Athletics (31-61), 13-0 | Cleveland Stadium (5-2) | 52-42 | Lost 2 |
| » Starters: Buck Ross vs Mel Harder | Second | 9½ out |
| » Defeated Athletics (31-62), 8-5 | Cleveland Stadium (6-2) | 53-42 | |
| » Starters: Gordon Rhodes vs Johnny Allen | Second | 9½ out |
| Tuesday, July 28 |
| » Defeated Senators (49-46), 6-3 | League Park II (22-17) | 54-42 | Won 2 |
| » Starters: Earl Whitehill vs Lloyd Brown | Second | 9 out |
| Wednesday, July 29 |
| » Defeated Senators (49-47), 11-6 | League Park II (23-17) | 55-42 | Won 3 |
| » Starters: Syd Cohen vs Thornton Lee | Second | 8½ out |
| » Defeated Senators (49-48), 6-5 | League Park II (24-17) | 56-42 | Won 4 |
| » Starters: Monte Weaver vs Denny Galehouse | Second | 8½ out |
| Thursday, July 30 |
| » Defeated Senators (49-49), 11-8 | League Park II (25-17) | 57-42 | Won 5 |
| » Starters: Jimmie DeShong vs George Blaeholder | Second | 7½ out |
| Friday, July 31 |
| » Lost to Yankees (65-34), 11-7 | League Park II (25-18) | 57-43 | |
| » Starters: Bump Hadley vs Mel Harder | Second | 8½ out |
| Future Indian Vic Davalillo is born in Cabimas, Venezuela. |
| Saturday, August 1 |
| » Lost to Yankees (66-34), 5-4 | League Park II (25-19) | 57-44 | Lost 2 |
| » Starters: Lefty Gomez vs Johnny Allen | Second | 9½ out |
| Sunday, August 2 |
| » Tied Yankees, 4-4 | Cleveland Stadium (6-2) | 57-44 | |
| » Starters: Monte Pearson vs Oral Hildebrand | Second | 9½ out |
| Monday, August 3 |
| » Lost to Tigers (54-47), 9-4 | Tiger Stadium (1-3) | 57-45 | Lost 3 |
| » Starters: Mel Harder vs Schoolboy Rowe | Second | 10 out |
| Tuesday, August 4 |
| » Lost to Tigers (55-47), 9-0 | Tiger Stadium (1-4) | 57-46 | Lost 4 |
| » Starters: Lloyd Brown vs Tommy Bridges | Second | 11 out |
| Wednesday, August 5 |
| » Defeated Tigers (55-48), 6-4 | Tiger Stadium (2-4) | 58-46 | |
| » Starters: Johnny Allen vs Elden Auker | Second | 11 out |
| Thursday, August 6 |
| » Lost to Tigers (56-48), 9-0 | Tiger Stadium (2-5) | 58-47 | |
| » Starters: Willis Hudlin vs Jake Wade | Second | 11½ out |
| Friday, August 7 |
| » Defeated White Sox (57-48), 8-1 | League Park II (26-19) | 59-47 | |
| » Starters: Italo Chelini vs Denny Galehouse | Second | 11 out |
| Saturday, August 8 |
| » Lost to White Sox (58-48), 9-7 | League Park II (26-20) | 59-48 | |
| » Starters: Vern Kennedy vs Mel Harder | Second | 12 out |
| Sunday, August 9 |
| » Defeated White Sox (58-49), 9-1 | Cleveland Stadium (7-2) | 60-48 | |
| » Starters: Ted Lyons vs Johnny Allen | Second | 12 out |
| » Defeated White Sox (58-50), 5-2 | Cleveland Stadium (8-2) | 61-48 | Won 2 |
| » Starters: Bill Dietrich vs Oral Hildebrand | Second | 12 out |
| Tuesday, August 11 |
| » Defeated Tigers (57-51), 6-5 | League Park II (27-20) | 62-48 | Won 3 |
| » Starters: Jake Wade vs Denny Galehouse | Second | 10½ out |
| Wednesday, August 12 |
| » Lost to Tigers (58-51), 7-4 | League Park II (27-21) | 62-49 | |
| » Starters: Tommy Bridges vs Willis Hudlin | Second | 11½ out |
| Future Indian Ellis Burton is born in Los Angeles, CA. |
| Thursday, August 13 |
| » Defeated Tigers (58-52), 8-0 | League Park II (28-21) | 63-49 | |
| » Starters: Schoolboy Rowe vs Johnny Allen | Second | 11 out |
| Friday, August 14 |
| » Defeated Browns (40-71), 12-10 | Sportsman's Park III (6-1) | 64-49 | Won 2 |
| » Starters: Oral Hildebrand vs Chief Hogsett | Second | 10 out |
| Saturday, August 15 |
| » Lost to Browns (41-71), 4-0 | Sportsman's Park III (6-2) | 64-50 | |
| » Starters: Denny Galehouse vs Earl Caldwell | Second | 11 out |
| Sunday, August 16 |
| » Lost to Browns (42-71), 9-2 | Sportsman's Park III (6-3) | 64-51 | Lost 2 |
| » Starters: Willis Hudlin vs Ivy Andrews | Second | 11½ out |
| Monday, August 17 |
| » Lost to White Sox (60-56), 7-3 | Comiskey Park I (1-6) | 64-52 | Lost 3 |
| » Starters: Johnny Allen vs Ted Lyons | Second | 11½ out |
| Tuesday, August 18 |
| » Lost to White Sox (61-56), 11-10 | Comiskey Park I (1-7) | 64-53 | Lost 4 |
| » Starters: Oral Hildebrand vs Clint Brown | Second | 11½ out |
| Friday, August 21 |
| » Defeated Browns (44-74), 4-2 | League Park II (29-21) | 65-53 | |
| » Starters: Ivy Andrews vs Mel Harder | Second | 12 out |
| Saturday, August 22 |
| » Defeated Browns (44-75), 6-0 | League Park II (30-21) | 66-53 | Won 2 |
| » Starters: Chief Hogsett vs Johnny Allen | Second | 12 out |
| Sunday, August 23 |
| » Defeated Browns (44-76), 4-1 | Cleveland Stadium (9-2) | 67-53 | Won 3 |
| » Starters: Earl Caldwell vs Bob Feller | Second | 11½ out |
| Tuesday, August 25 |
| » Lost to Senators (63-59), 5-3 | Griffith Stadium (6-3) | 67-54 | |
| » Starters: Thornton Lee vs Bobo Newsom | Second | 12½ out |
| Wednesday, August 26 |
| » Lost to Senators (64-59), 14-1 | Griffith Stadium (6-4) | 67-55 | Lost 2 |
| » Starters: Denny Galehouse vs Joe Cascarella | Second | 12½ out |
| Thursday, August 27 |
| » Defeated Senators (64-60), 10-9 | Griffith Stadium (7-4) | 68-55 | |
| » Starters: Mel Harder vs Earl Whitehill | Second | 12½ out |
| Saturday, August 29 |
| » Defeated Athletics (45-80), 13-2 | Shibe Park (7-3) | 69-55 | Won 2 |
| » Starters: Johnny Allen vs Gordon Rhodes | Second | 14 out |
| » Lost to Athletics (46-80), 5-3 | Shibe Park (7-4) | 69-56 | |
| » Starters: Denny Galehouse vs Buck Ross | Second | 14 out |
| Sunday, August 30 |
| » Lost to Red Sox (63-65), 3-2 | Fenway Park (4-5) | 69-57 | Lost 2 |
| » Starters: Oral Hildebrand vs Wes Ferrell | Second | 16 out |
| » Lost to Red Sox (64-65), 5-1 | Fenway Park (4-6) | 69-58 | Lost 3 |
| » Starters: Bob Feller vs Rube Walberg | Second | 16 out |
| Tuesday, September 1 |
| » Lost to Red Sox (65-65), 4-1 | Fenway Park (4-7) | 69-59 | Lost 4 |
| » Starters: Mel Harder vs Lefty Grove | Second | 17 out |
| Wednesday, September 2 |
| » Defeated Yankees (86-43), 4-3 | Yankee Stadium (4-6) | 70-59 | |
| » Starters: Johnny Allen vs Red Ruffing | Second | 16 out |
| Thursday, September 3 |
| » Lost to Yankees (87-43), 6-4 | Yankee Stadium (4-7) | 70-60 | |
| » Starters: Bob Feller vs Lefty Gomez | Second | 17 out |
| Saturday, September 5 |
| » Lost to White Sox (69-63), 9-0 | Comiskey Park I (1-8) | 70-61 | Lost 2 |
| » Starters: Oral Hildebrand vs Vern Kennedy | Second | 17½ out |
| Sunday, September 6 |
| » Lost to White Sox (70-63), 15-1 | Comiskey Park I (1-9) | 70-62 | Lost 3 |
| » Starters: Mel Harder vs Ted Lyons | Fourth | 17½ out |
| » Lost to White Sox (71-63), 6-3 | Comiskey Park I (1-10) | 70-63 | Lost 4 |
| » Starters: Johnny Allen vs Monty Stratton | Fourth | 17½ out |
| Monday, September 7 |
| » Lost to Browns (49-83), 6-4 | League Park II (30-22) | 70-64 | Lost 5 |
| » Starters: Chief Hogsett vs Denny Galehouse | Fourth | 18½ out |
| » Defeated Browns (49-84), 7-1 | League Park II (31-22) | 71-64 | |
| » Starters: Ivy Andrews vs Bob Feller | Fourth | 18½ out |
| Wednesday, September 9 |
| » Lost to Yankees (91-46), 11-3 | League Park II (31-23) | 71-65 | |
| » Starters: Monte Pearson vs Mel Harder | Fifth | 20½ out |
| » Lost to Yankees (92-46), 12-9 | League Park II (31-24) | 71-66 | Lost 2 |
| » Starters: Bump Hadley vs Oral Hildebrand | Fifth | 20½ out |
| Thursday, September 10 |
| » Defeated Yankees (92-47), 5-4 | League Park II (32-24) | 72-66 | |
| » Starters: Johnny Broaca vs Johnny Allen | Fourth | 19½ out |
| Friday, September 11 |
| » Lost to Senators (74-66), 7-2 | League Park II (32-25) | 72-67 | |
| » Starters: Earl Whitehill vs Denny Galehouse | Fifth | 20½ out |
| Former Indian Braggo Roth dies in Chicago, IL at the age of 45. |
| Saturday, September 12 |
| » Lost to Senators (75-66), 12-2 | League Park II (32-26) | 72-68 | Lost 2 |
| » Starters: Jimmie DeShong vs Al Milnar | Fifth | 20½ out |
| Sunday, September 13 |
| » Defeated Athletics (49-92), 5-2 | Cleveland Stadium (10-2) | 73-68 | |
| » Starters: Randy Gumpert vs Bob Feller | Fourth | 20½ out |
| » Defeated Athletics (49-93), 5-4 | Cleveland Stadium (11-2) | 74-68 | Won 2 |
| » Starters: Herman Fink vs Denny Galehouse | Fourth | 20½ out |
| » Major-league debuts: Jeff Heath (Indians) |
| Monday, September 14 |
| Future Indian Stan Williams is born in Enfield, NH. |
| Tuesday, September 15 |
| » Defeated Red Sox (72-73), 13-2 | League Park II (33-26) | 75-68 | Won 3 |
| » Starters: Jennings Poindexter vs Johnny Allen | Fifth | 20½ out |
| Wednesday, September 16 |
| » Defeated Red Sox (72-74), 13-3 | League Park II (34-26) | 76-68 | Won 4 |
| » Starters: Ted Olson vs Bill Zuber | Fourth | 20 out |
| » Major-league debuts: Bill Zuber (Indians) |
| Thursday, September 17 |
| » Lost to Tigers (78-68), 5-2 | Tiger Stadium (2-6) | 76-69 | |
| » Starters: Denny Galehouse vs Jake Wade | Fifth | 20½ out |
| Friday, September 18 |
| » Lost to Tigers (79-68), 6-3 | Tiger Stadium (2-7) | 76-70 | Lost 2 |
| » Starters: Bob Feller vs Tommy Bridges | Fifth | 21 out |
| Saturday, September 19 |
| » Lost to Tigers (80-68), 7-3 | Tiger Stadium (2-8) | 76-71 | Lost 3 |
| » Starters: Mel Harder vs Schoolboy Rowe | Fifth | 22 out |
| Former Indian Bill Hart dies in Cincinnati, OH at the age of 72. |
| Sunday, September 20 |
| » Lost to Tigers (81-68), 5-3 | Tiger Stadium (2-9) | 76-72 | Lost 4 |
| » Starters: Al Milnar vs Jake Wade | Fifth | 22½ out |
| Tuesday, September 22 |
| » Tied White Sox, 8-8 | League Park II (34-26) | 76-72 | |
| » Starters: Monty Stratton vs Denny Galehouse | Fifth | 23 out |
| Wednesday, September 23 |
| » Defeated White Sox (78-70), 17-2 | League Park II (35-26) | 77-72 | |
| » Starters: Vern Kennedy vs Bob Feller | Fifth | 23½ out |
| » Lost to White Sox (79-70), 8-3 | League Park II (35-27) | 77-73 | |
| » Starters: Bill Dietrich vs Mel Harder | Fifth | 23½ out |
| Friday, September 25 |
| » Lost to Browns (57-92), 8-2 | League Park II (35-28) | 77-74 | Lost 2 |
| » Starters: Chief Hogsett vs Bill Zuber | Fifth | 23½ out |
| » Defeated Browns (57-93), 7-6 | League Park II (36-28) | 78-74 | |
| » Starters: Russ VanAtta vs Al Milnar | Fifth | 23½ out |
| Saturday, September 26 |
| » Defeated Tigers (83-70), 5-3 | League Park II (37-28) | 79-74 | Won 2 |
| » Starters: Tommy Bridges vs Willis Hudlin | Fifth | 23½ out |
| Sunday, September 27 |
| » Defeated Tigers (83-71), 9-1 | Cleveland Stadium (12-2) | 80-74 | Won 3 |
| » Starters: Schoolboy Rowe vs Bob Feller | Fifth | 22½ out |
| Tuesday, October 27 |
| Future Indian Lee Stange is born in Chicago, IL. |
| Saturday, October 31 |
| Former Indian Deacon McGuire dies in Duck Lake, MI at the age of 73. |
| Tuesday, November 17 |
| Future Indian Gary Bell is born in San Antonio, TX. |
| Thursday, December 10 |
| Future Indian Doc Edwards is born in Red Jacket, WV. |
Game information provided by Retrosheet (www.retrosheet.org) |