| Saturday, January 20 |
| Future Indian Camilo Pascual is born in Havana, Cuba. |
| Saturday, February 17 |
| Future Indian Willie Kirkland is born in Siluria, AL. |
| Saturday, March 3 |
| Future Indian Larry Locke is born in Rowes Run, PA. |
| Tuesday, April 17 |
| » Defeated Browns (0-1), 5-2 | League Park II (1-0) | 1-0 | |
| » Starters: George Blaeholder vs Oral Hildebrand | First | -- |
| » Major-league debuts: Harlond Clift and Alan Strange (Browns) |
| Wednesday, April 18 |
| » Lost to Browns (1-1), 2-0 | League Park II (1-1) | 1-1 | |
| » Starters: Bump Hadley vs Monte Pearson | Second | 1 out |
| Thursday, April 19 |
| » Defeated Browns (1-2), 3-2 | League Park II (2-1) | 2-1 | |
| » Starters: Ed Wells vs Mel Harder | First | -- |
| Former Indian Piano Legs Hickman dies in Morgantown, WV at the age of 59. |
| Friday, April 20 |
| » Lost to Tigers (3-1), 4-0 | League Park II (2-2) | 2-2 | |
| » Starters: Carl Fischer vs Lloyd Brown | Third | 1 out |
| Tuesday, April 24 |
| » Defeated Browns (2-3), 15-2 | Sportsman's Park III (1-0) | 3-2 | |
| » Starters: Oral Hildebrand vs Bump Hadley | Third | 1 out |
| » Major-league debuts: Ollie Bejma (Browns) |
| Wednesday, April 25 |
| » Defeated Browns (2-4), 5-1 | Sportsman's Park III (2-0) | 4-2 | Won 2 |
| » Starters: Monte Pearson vs George Blaeholder | Second | ½ out |
| Saturday, April 28 |
| » Lost to Tigers (6-2), 4-1 | Tiger Stadium (0-1) | 4-3 | |
| » Starters: Mel Harder vs Tommy Bridges | Second | 1½ out |
| Sunday, April 29 |
| » Defeated Tigers (6-3), 7-1 | Tiger Stadium (1-1) | 5-3 | |
| » Starters: Oral Hildebrand vs Firpo Marberry | Second | ½ out |
| Monday, April 30 |
| » Lost to White Sox (4-6), 20-10 | Comiskey Park I (0-1) | 5-4 | |
| » Starters: Monte Pearson vs Sam Jones | Third | 1 out |
| » Major-league debuts: Denny Galehouse (Indians) |
| Tuesday, May 1 |
| » Defeated White Sox (4-7), 12-1 | Comiskey Park I (1-1) | 6-4 | |
| » Starters: Willis Hudlin vs Milt Gaston | Third | 1 out |
| Thursday, May 3 |
| Future Indian Chuck Hinton is born in Rocky Mount, NC. |
| Friday, May 4 |
| » Defeated Senators (7-8), 5-3 | Griffith Stadium (1-0) | 7-4 | Won 2 |
| » Starters: Lloyd Brown vs Earl Whitehill | Second | 1½ out |
| Saturday, May 5 |
| » Lost to Senators (8-8), 9-1 | Griffith Stadium (1-1) | 7-5 | |
| » Starters: Oral Hildebrand vs Lefty Stewart | Second | 1½ out |
| Sunday, May 6 |
| » Defeated Athletics (7-9), 4-3 | Shibe Park (1-0) | 8-5 | |
| » Starters: Willis Hudlin vs Roy Mahaffey | Second | 1½ out |
| Monday, May 7 |
| » Lost to Athletics (8-9), 7-3 | Shibe Park (1-1) | 8-6 | |
| » Starters: Mel Harder vs Sugar Cain | Second | 2½ out |
| Tuesday, May 8 |
| » Lost to Athletics (9-9), 2-0 | Shibe Park (1-2) | 8-7 | Lost 2 |
| » Starters: Lloyd Brown vs Joe Cascarella | Third | 3½ out |
| Wednesday, May 9 |
| » Lost to Athletics (10-9), 5-4 | Shibe Park (1-3) | 8-8 | Lost 3 |
| » Starters: Monte Pearson vs Johnny Marcum | Fourth | 3½ out |
| Thursday, May 10 |
| » Defeated Red Sox (10-10), 11-10 | Fenway Park (1-0) | 9-8 | |
| » Starters: Willis Hudlin vs Rube Walberg | Third | 3½ out |
| Friday, May 11 |
| » Defeated Red Sox (10-11), 6-5 | Fenway Park (2-0) | 10-8 | Won 2 |
| » Starters: Mel Harder vs Fritz Ostermueller | Second | 3½ out |
| Saturday, May 12 |
| » Defeated Red Sox (10-12), 7-2 | Fenway Park (3-0) | 11-8 | Won 3 |
| » Starters: Oral Hildebrand vs Bob Weiland | Second | 3½ out |
| Sunday, May 13 |
| » Lost to Yankees (17-6), 8-0 | Yankee Stadium (0-1) | 11-9 | |
| » Starters: Lloyd Brown vs Lefty Gomez | Second | 4½ out |
| Future Indian Leon Wagner is born in Chattanooga, TN. |
| Thursday, May 17 |
| » Defeated Senators (12-14), 14-6 | League Park II (3-2) | 12-9 | |
| » Starters: Earl Whitehill vs Monte Pearson | Second | 3½ out |
| Friday, May 18 |
| » Lost to Senators (13-14), 3-1 | League Park II (3-3) | 12-10 | |
| » Starters: Lefty Stewart vs Lloyd Brown | Third | 3½ out |
| Saturday, May 19 |
| » Lost to Senators (14-14), 3-2 | League Park II (3-4) | 12-11 | Lost 2 |
| » Starters: Monte Weaver vs Mel Harder | Third | 4½ out |
| Sunday, May 20 |
| » Defeated Yankees (18-9), 8-5 | Cleveland Stadium (1-0) | 13-11 | |
| » Starters: Danny MacFayden vs Monte Pearson | Second | 3½ out |
| Monday, May 21 |
| » Defeated Yankees (18-10), 9-5 | League Park II (4-4) | 14-11 | Won 2 |
| » Starters: George Uhle vs Willis Hudlin | Second | 2½ out |
| Tuesday, May 22 |
| » Defeated Yankees (18-11), 5-1 | League Park II (5-4) | 15-11 | Won 3 |
| » Starters: Johnny Murphy vs Lloyd Brown | Second | 1½ out |
| Wednesday, May 23 |
| » Lost to Red Sox (15-16), 7-5 | League Park II (5-5) | 15-12 | |
| » Starters: Lefty Grove vs Mel Harder | Second | 1½ out |
| Friday, May 25 |
| » Defeated Red Sox (15-17), 18-3 | League Park II (6-5) | 16-12 | |
| » Starters: Gordon Rhodes vs Monte Pearson | Second | 2 out |
| Saturday, May 26 |
| » Defeated Athletics (15-18), 7-0 | League Park II (7-5) | 17-12 | Won 2 |
| » Starters: Joe Cascarella vs Willis Hudlin | Second | 2 out |
| Future Indian Jim Mahoney is born in Englewood, NJ. |
| Sunday, May 27 |
| » Defeated Athletics (15-19), 7-6 | Cleveland Stadium (2-0) | 18-12 | Won 3 |
| » Starters: Roy Mahaffey vs Lloyd Brown | First | -- |
| Monday, May 28 |
| » Defeated Athletics (15-20), 6-5 | League Park II (8-5) | 19-12 | Won 4 |
| » Starters: Johnny Marcum vs Oral Hildebrand | First | -- |
| Tuesday, May 29 |
| » Defeated White Sox (13-21), 5-0 | League Park II (9-5) | 20-12 | Won 5 |
| » Starters: Milt Gaston vs Mel Harder | First | -- |
| Wednesday, May 30 |
| » Lost to White Sox (14-21), 8-7 | League Park II (9-6) | 20-13 | |
| » Starters: George Earnshaw vs Monte Pearson | First | -- |
| » Defeated White Sox (14-22), 5-4 | League Park II (10-6) | 21-13 | |
| » Starters: Les Tietje vs Willis Hudlin | First | -- |
| Thursday, May 31 |
| » Lost to White Sox (15-22), 12-5 | League Park II (10-7) | 21-14 | |
| » Starters: Sam Jones vs Belve Bean | First | -- |
| Saturday, June 2 |
| » Lost to Browns (19-19), 3-2 | Sportsman's Park III (2-1) | 21-15 | Lost 2 |
| » Starters: Lloyd Brown vs Bobo Newsom | First | -- |
| Sunday, June 3 |
| » Lost to Browns (20-19), 12-8 | Sportsman's Park III (2-2) | 21-16 | Lost 3 |
| » Starters: Oral Hildebrand vs Bump Hadley | Third | 2 out |
| Tuesday, June 5 |
| » Lost to Tigers (25-18), 20-2 | Tiger Stadium (1-2) | 21-17 | Lost 4 |
| » Starters: Lloyd Brown vs Vic Sorrell | Third | 1½ out |
| » Defeated Tigers (25-19), 5-4 | Tiger Stadium (2-2) | 22-17 | |
| » Starters: Monte Pearson vs Elden Auker | Third | 1½ out |
| Wednesday, June 6 |
| » Lost to Tigers (26-19), 2-1 | Tiger Stadium (2-3) | 22-18 | |
| » Starters: Bob Weiland vs Schoolboy Rowe | Third | 2½ out |
| Thursday, June 7 |
| » Lost to Tigers (27-19), 11-6 | Tiger Stadium (2-4) | 22-19 | Lost 2 |
| » Starters: Oral Hildebrand vs Tommy Bridges | Third | 2½ out |
| Friday, June 8 |
| » Lost to Browns (24-20), 8-6 | League Park II (10-8) | 22-20 | Lost 3 |
| » Starters: Ed Wells vs Willis Hudlin | Fourth | 3½ out |
| Saturday, June 9 |
| » Defeated Browns (24-21), 3-1 | League Park II (11-8) | 23-20 | |
| » Starters: Ivy Andrews vs Monte Pearson | Third | 3½ out |
| Sunday, June 10 |
| » Defeated Browns (24-22), 6-1 | Cleveland Stadium (3-0) | 24-20 | Won 2 |
| » Starters: Dick Coffman vs Bob Weiland | Third | 2½ out |
| » Major-league debuts: Lefty Mills (Browns) |
| Wednesday, June 13 |
| » Lost to Athletics (20-28), 11-2 | Shibe Park (1-4) | 24-21 | |
| » Starters: Monte Pearson vs Sugar Cain | Third | 3 out |
| Thursday, June 14 |
| » Defeated Athletics (20-29), 11-7 | Shibe Park (2-4) | 25-21 | |
| » Starters: Mel Harder vs Joe Cascarella | Third | 2½ out |
| Friday, June 15 |
| » Defeated Athletics (20-30), 12-6 | Shibe Park (3-4) | 26-21 | Won 2 |
| » Starters: Oral Hildebrand vs Roy Mahaffey | Third | 2½ out |
| Saturday, June 16 |
| » Lost to Senators (30-25), 7-1 | Griffith Stadium (1-2) | 26-22 | |
| » Starters: Bob Weiland vs Tommy Thomas | Fourth | 4 out |
| » Lost to Senators (31-25), 5-3 | Griffith Stadium (1-3) | 26-23 | Lost 2 |
| » Starters: Lloyd Brown vs Bobby Burke | Fourth | 4 out |
| Sunday, June 17 |
| » Defeated Senators (31-26), 8-5 | Griffith Stadium (2-3) | 27-23 | |
| » Starters: Monte Pearson vs Earl Whitehill | Fourth | 3½ out |
| Tuesday, June 19 |
| » Lost to Senators (32-26), 6-2 | Griffith Stadium (2-4) | 27-24 | |
| » Starters: Oral Hildebrand vs Lefty Stewart | Fourth | 3 out |
| » Defeated Senators (32-27), 3-0 | Griffith Stadium (3-4) | 28-24 | |
| » Starters: Mel Harder vs Monte Weaver | Fourth | 3 out |
| Wednesday, June 20 |
| » Lost to Yankees (33-22), 3-2 | Yankee Stadium (0-2) | 28-25 | |
| » Starters: Bob Weiland vs Johnny Broaca | Fifth | 5 out |
| » Lost to Yankees (34-22), 3-0 | Yankee Stadium (0-3) | 28-26 | Lost 2 |
| » Starters: Lloyd Brown vs Red Ruffing | Fifth | 5 out |
| Thursday, June 21 |
| » Defeated Yankees (34-23), 9-5 | Yankee Stadium (1-3) | 29-26 | |
| » Starters: Willis Hudlin vs Danny MacFayden | Fourth | 4 out |
| Friday, June 22 |
| » Defeated Yankees (34-24), 4-1 | Yankee Stadium (2-3) | 30-26 | Won 2 |
| » Starters: Monte Pearson vs Lefty Gomez | Third | 3½ out |
| Future Indian Russ Snyder is born in Oak, NE. |
| Saturday, June 23 |
| » Lost to Yankees (35-24), 6-3 | Yankee Stadium (2-4) | 30-27 | |
| » Starters: Oral Hildebrand vs Johnny Murphy | Fourth | 5 out |
| Sunday, June 24 |
| » Defeated Red Sox (33-29), 6-2 | Fenway Park (4-0) | 31-27 | |
| » Starters: Mel Harder vs Wes Ferrell | Third | 5 out |
| Monday, June 25 |
| » Lost to Red Sox (34-29), 6-3 | Fenway Park (4-1) | 31-28 | |
| » Starters: Bob Weiland vs Gordon Rhodes | Fifth | 5 out |
| Tuesday, June 26 |
| » Defeated Red Sox (34-30), 10-2 | Fenway Park (5-1) | 32-28 | |
| » Starters: Willis Hudlin vs Fritz Ostermueller | Fourth | 5 out |
| Wednesday, June 27 |
| » Lost to Red Sox (35-30), 6-0 | Fenway Park (5-2) | 32-29 | |
| » Starters: Monte Pearson vs Hank Johnson | Fifth | 6 out |
| Friday, June 29 |
| » Defeated White Sox (21-46), 5-2 | Comiskey Park I (2-1) | 33-29 | |
| » Starters: Mel Harder vs Les Tietje | Third | 6 out |
| Saturday, June 30 |
| » Lost to White Sox (22-46), 2-1 | Comiskey Park I (2-2) | 33-30 | |
| » Starters: Willis Hudlin vs George Earnshaw | Fourth | 6½ out |
| Sunday, July 1 |
| » Lost to White Sox (23-46), 12-5 | Comiskey Park I (2-3) | 33-31 | Lost 2 |
| » Starters: Monte Pearson vs Ted Lyons | Fourth | 7 out |
| » Defeated White Sox (23-47), 4-3 | Comiskey Park I (3-3) | 34-31 | |
| » Starters: Oral Hildebrand vs Milt Gaston | Fourth | 7 out |
| Monday, July 2 |
| » Lost to Tigers (42-27), 9-2 | League Park II (11-9) | 34-32 | |
| » Starters: Tommy Bridges vs Lloyd Brown | Fifth | 7½ out |
| » Defeated Tigers (42-28), 6-5 | League Park II (12-9) | 35-32 | |
| » Starters: Elden Auker vs Bob Weiland | Fifth | 7½ out |
| Tuesday, July 3 |
| » Lost to Tigers (43-28), 7-2 | League Park II (12-10) | 35-33 | |
| » Starters: Luke Hamlin vs Monte Pearson | Fifth | 7½ out |
| Wednesday, July 4 |
| » Defeated Tigers (43-29), 8-6 | Tiger Stadium (3-4) | 36-33 | |
| » Starters: Mel Harder vs Firpo Marberry | Fifth | 7½ out |
| » Lost to Tigers (44-29), 5-2 | Tiger Stadium (3-5) | 36-34 | |
| » Starters: Willis Hudlin vs Carl Fischer | Fifth | 7½ out |
| Thursday, July 5 |
| » Defeated White Sox (24-49), 8-0 | League Park II (13-10) | 37-34 | |
| » Starters: George Earnshaw vs Oral Hildebrand | Fourth | 7½ out |
| Future Indian Gordy Coleman is born in Rockville, MD. |
| Friday, July 6 |
| » Lost to White Sox (25-49), 7-5 | League Park II (13-11) | 37-35 | |
| » Starters: Milt Gaston vs Ralph Winegarner | Fifth | 7½ out |
| » Major-league debuts: Jocko Conlan (White Sox) |
| Sunday, July 8 |
| » Defeated White Sox (25-50), 5-1 | Cleveland Stadium (4-0) | 38-35 | |
| » Starters: Sam Jones vs Willis Hudlin | Fourth | 7½ out |
| » Defeated White Sox (25-51), 10-5 | Cleveland Stadium (5-0) | 39-35 | Won 2 |
| » Starters: Whit Wyatt vs Monte Pearson | Fourth | 7½ out |
| Wednesday, July 11 |
| » Lost to Yankees (47-27), 9-4 | League Park II (13-12) | 39-36 | |
| » Starters: Johnny Murphy vs Lloyd Brown | Fourth | 8½ out |
| Friday, July 13 |
| » Lost to Senators (40-39), 3-2 | League Park II (13-13) | 39-37 | Lost 2 |
| » Starters: Lefty Stewart vs Oral Hildebrand | Fourth | 9 out |
| Saturday, July 14 |
| » Defeated Senators (40-40), 2-0 | League Park II (14-13) | 40-37 | |
| » Starters: Earl Whitehill vs Mel Harder | Fourth | 8½ out |
| Sunday, July 15 |
| » Defeated Senators (40-41), 10-8 | Cleveland Stadium (6-0) | 41-37 | Won 2 |
| » Starters: Monte Weaver vs Willis Hudlin | Fourth | 8 out |
| » Defeated Senators (40-42), 10-8 | Cleveland Stadium (7-0) | 42-37 | Won 3 |
| » Starters: Tommy Thomas vs Monte Pearson | Fourth | 8 out |
| Monday, July 16 |
| » Lost to Yankees (49-30), 7-4 | League Park II (14-14) | 42-38 | |
| » Starters: Johnny Allen vs Thornton Lee | Fourth | 8 out |
| Tuesday, July 17 |
| » Defeated Yankees (49-31), 13-5 | League Park II (15-14) | 43-38 | |
| » Starters: Johnny Broaca vs Oral Hildebrand | Fourth | 8 out |
| Wednesday, July 18 |
| » Defeated Yankees (49-32), 15-14 | League Park II (16-14) | 44-38 | Won 2 |
| » Starters: Red Ruffing vs Mel Harder | Fourth | 8 out |
| Thursday, July 19 |
| » Defeated Red Sox (47-39), 6-5 | League Park II (17-14) | 45-38 | Won 3 |
| » Starters: Fritz Ostermueller vs Willis Hudlin | Fourth | 7½ out |
| Friday, July 20 |
| » Defeated Red Sox (47-40), 5-3 | League Park II (18-14) | 46-38 | Won 4 |
| » Starters: Rube Walberg vs Monte Pearson | Third | 6½ out |
| Saturday, July 21 |
| » Lost to Red Sox (48-40), 7-6 | League Park II (18-15) | 46-39 | |
| » Starters: Wes Ferrell vs Oral Hildebrand | Fourth | 7½ out |
| Sunday, July 22 |
| » Defeated Red Sox (48-41), 4-2 | Cleveland Stadium (8-0) | 47-39 | |
| » Starters: Hank Johnson vs Mel Harder | Third | 6½ out |
| » Defeated Red Sox (48-42), 6-5 | Cleveland Stadium (9-0) | 48-39 | Won 2 |
| » Starters: Joe Mulligan vs Thornton Lee | Third | 6½ out |
| Monday, July 23 |
| » Lost to Athletics (35-52), 11-9 | League Park II (18-16) | 48-40 | |
| » Starters: Sugar Cain vs Willis Hudlin | Third | 7½ out |
| Tuesday, July 24 |
| » Defeated Athletics (35-53), 10-6 | League Park II (19-16) | 49-40 | |
| » Starters: Johnny Marcum vs Monte Pearson | Third | 7½ out |
| Wednesday, July 25 |
| » Defeated Athletics (35-54), 8-3 | League Park II (20-16) | 50-40 | Won 2 |
| » Starters: Mort Flohr vs Oral Hildebrand | Third | 6½ out |
| Saturday, July 28 |
| » Defeated Browns (40-46), 10-8 | Sportsman's Park III (3-2) | 51-40 | Won 3 |
| » Starters: Mel Harder vs Ivy Andrews | Third | 6½ out |
| » Lost to Browns (41-46), 3-2 | Sportsman's Park III (3-3) | 51-41 | |
| » Starters: Willis Hudlin vs Bump Hadley | Third | 6½ out |
| Sunday, July 29 |
| » Defeated Browns (41-47), 11-5 | Sportsman's Park III (4-3) | 52-41 | |
| » Starters: Oral Hildebrand vs George Blaeholder | Third | 5½ out |
| » Defeated Browns (41-48), 6-3 | Sportsman's Park III (5-3) | 53-41 | Won 2 |
| » Starters: Monte Pearson vs Bobo Newsom | Third | 5½ out |
| Tuesday, July 31 |
| » Defeated Tigers (59-37), 9-7 | League Park II (21-16) | 54-41 | Won 3 |
| » Starters: Carl Fischer vs Thornton Lee | Third | 5½ out |
| » Lost to Tigers (60-37), 4-2 | League Park II (21-17) | 54-42 | |
| » Starters: Tommy Bridges vs Bob Weiland | Third | 5½ out |
| Wednesday, August 1 |
| » Lost to Tigers (61-37), 10-7 | League Park II (21-18) | 54-43 | Lost 2 |
| » Starters: Luke Hamlin vs Willis Hudlin | Third | 6½ out |
| Thursday, August 2 |
| » Lost to Tigers (62-37), 3-0 | League Park II (21-19) | 54-44 | Lost 3 |
| » Starters: Elden Auker vs Mel Harder | Third | 7½ out |
| Friday, August 3 |
| » Defeated Browns (43-52), 6-4 | League Park II (22-19) | 55-44 | |
| » Starters: George Blaeholder vs Monte Pearson | Third | 7½ out |
| Saturday, August 4 |
| » Lost to Browns (44-52), 8-7 | League Park II (22-20) | 55-45 | |
| » Starters: Bump Hadley vs Oral Hildebrand | Third | 8½ out |
| Sunday, August 5 |
| » Defeated Browns (44-53), 5-2 | Cleveland Stadium (10-0) | 56-45 | |
| » Starters: Bobo Newsom vs Willis Hudlin | Third | 8½ out |
| Tuesday, August 7 |
| » Lost to White Sox (37-68), 8-2 | Comiskey Park I (3-4) | 56-46 | |
| » Starters: Mel Harder vs George Earnshaw | Third | 9½ out |
| Wednesday, August 8 |
| » Defeated White Sox (37-69), 11-4 | Comiskey Park I (4-4) | 57-46 | |
| » Starters: Monte Pearson vs Sam Jones | Third | 9½ out |
| Friday, August 10 |
| » Lost to Tigers (69-37), 6-5 | Tiger Stadium (3-6) | 57-47 | |
| » Starters: Oral Hildebrand vs Schoolboy Rowe | Third | 11 out |
| Saturday, August 11 |
| » Lost to Tigers (70-37), 7-0 | Tiger Stadium (3-7) | 57-48 | Lost 2 |
| » Starters: Willis Hudlin vs Elden Auker | Third | 12 out |
| Sunday, August 12 |
| » Lost to Tigers (71-37), 6-5 | Tiger Stadium (3-8) | 57-49 | Lost 3 |
| » Starters: Monte Pearson vs Luke Hamlin | Third | 13 out |
| Tuesday, August 14 |
| » Defeated Senators (49-59), 5-1 | Griffith Stadium (4-4) | 58-49 | |
| » Starters: Mel Harder vs Lefty Stewart | Third | 13½ out |
| Friday, August 17 |
| » Lost to Senators (50-59), 4-3 | Griffith Stadium (4-5) | 58-50 | |
| » Starters: Oral Hildebrand vs Earl Whitehill | Third | 14 out |
| » Lost to Senators (51-59), 1-0 | Griffith Stadium (4-6) | 58-51 | Lost 2 |
| » Starters: Monte Pearson vs Bobby Burke | Third | 14 out |
| Saturday, August 18 |
| » Lost to Athletics (46-62), 2-1 | Shibe Park (3-5) | 58-52 | Lost 3 |
| » Starters: Willis Hudlin vs Johnny Marcum | Fourth | 13½ out |
| » Defeated Athletics (46-63), 10-0 | Shibe Park (4-5) | 59-52 | |
| » Starters: Mel Harder vs Roy Mahaffey | Fourth | 13½ out |
| Sunday, August 19 |
| » Lost to Athletics (47-63), 9-5 | Shibe Park (4-6) | 59-53 | |
| » Starters: Clint Brown vs Sugar Cain | Third | 15 out |
| Tuesday, August 21 |
| » Defeated Athletics (47-64), 12-11 | Shibe Park (5-6) | 60-53 | |
| » Starters: Oral Hildebrand vs Al Benton | Third | 15 out |
| Wednesday, August 22 |
| » Lost to Yankees (72-45), 9-0 | Yankee Stadium (2-5) | 60-54 | |
| » Starters: Monte Pearson vs Lefty Gomez | Third | 14½ out |
| » Defeated Yankees (72-46), 10-4 | Yankee Stadium (3-5) | 61-54 | |
| » Starters: Mel Harder vs Jimmie DeShong | Third | 14½ out |
| Thursday, August 23 |
| » Lost to Yankees (73-46), 9-2 | Yankee Stadium (3-6) | 61-55 | |
| » Starters: Willis Hudlin vs Red Ruffing | Third | 14½ out |
| Future Indian Johnny Romano is born in Hoboken, NJ. |
| Saturday, August 25 |
| » Defeated Yankees (73-47), 5-3 | Yankee Stadium (4-6) | 62-55 | |
| » Starters: Monte Pearson vs Johnny Murphy | Third | 15½ out |
| » Lost to Yankees (74-47), 9-3 | Yankee Stadium (4-7) | 62-56 | |
| » Starters: Thornton Lee vs Johnny Broaca | Third | 15½ out |
| Sunday, August 26 |
| » Defeated Red Sox (63-61), 3-2 | Fenway Park (6-2) | 63-56 | |
| » Starters: Oral Hildebrand vs Wes Ferrell | Third | 16 out |
| » Lost to Red Sox (64-61), 5-2 | Fenway Park (6-3) | 63-57 | |
| » Starters: Mel Harder vs Fritz Ostermueller | Third | 16 out |
| Monday, August 27 |
| » Defeated Red Sox (64-62), 6-5 | Fenway Park (7-3) | 64-57 | |
| » Starters: Willis Hudlin vs Herb Pennock | Third | 16 out |
| Tuesday, August 28 |
| » Lost to Red Sox (65-62), 8-2 | Fenway Park (7-4) | 64-58 | |
| » Starters: Ralph Winegarner vs Lefty Grove | Third | 16½ out |
| Thursday, August 30 |
| » Lost to Tigers (83-43), 6-1 | League Park II (22-21) | 64-59 | Lost 2 |
| » Starters: Carl Fischer vs Monte Pearson | Third | 17½ out |
| Saturday, September 1 |
| » Lost to Tigers (84-43), 6-4 | League Park II (22-22) | 64-60 | Lost 3 |
| » Starters: Tommy Bridges vs Oral Hildebrand | Third | 18½ out |
| Sunday, September 2 |
| » Defeated Tigers (84-44), 1-0 | Cleveland Stadium (11-0) | 65-60 | |
| » Starters: Elden Auker vs Mel Harder | Third | 17½ out |
| Monday, September 3 |
| » Defeated Browns (59-67), 9-5 | Sportsman's Park III (6-3) | 66-60 | Won 2 |
| » Starters: Monte Pearson vs George Blaeholder | Third | 16½ out |
| » Defeated Browns (59-68), 6-4 | Sportsman's Park III (7-3) | 67-60 | Won 3 |
| » Starters: Willis Hudlin vs Ed Wells | Third | 16½ out |
| Tuesday, September 4 |
| » Defeated Browns (59-69), 8-4 | Sportsman's Park III (8-3) | 68-60 | Won 4 |
| » Starters: Lloyd Brown vs Jack Knott | Third | 16 out |
| Wednesday, September 5 |
| » Defeated Red Sox (67-64), 11-2 | League Park II (23-22) | 69-60 | Won 5 |
| » Starters: Lefty Grove vs Ralph Winegarner | Third | 16 out |
| Thursday, September 6 |
| » Lost to Red Sox (68-64), 6-1 | League Park II (23-23) | 69-61 | |
| » Starters: Gordon Rhodes vs Mel Harder | Third | 16½ out |
| Saturday, September 8 |
| » Defeated Red Sox (68-65), 5-1 | League Park II (24-23) | 70-61 | |
| » Starters: Wes Ferrell vs Monte Pearson | Third | 14½ out |
| » Defeated Red Sox (68-66), 3-2 | League Park II (25-23) | 71-61 | Won 2 |
| » Starters: Fritz Ostermueller vs Willis Hudlin | Third | 14½ out |
| Sunday, September 9 |
| » Defeated Athletics (55-75), 8-3 | Cleveland Stadium (12-0) | 72-61 | Won 3 |
| » Starters: Jack Wilson vs Oral Hildebrand | Third | 14 out |
| » Defeated Athletics (55-76), 6-5 | Cleveland Stadium (13-0) | 73-61 | Won 4 |
| » Starters: Johnny Marcum vs Clint Brown | Third | 14 out |
| » Major-league debuts: Jack Wilson (Athletics) |
| Monday, September 10 |
| » Lost to Athletics (56-76), 9-6 | League Park II (25-24) | 73-62 | |
| » Starters: George Caster vs Ralph Winegarner | Third | 15 out |
| Future Indian Roger Maris is born in Hibbing, MN. |
| Tuesday, September 11 |
| » Lost to Athletics (57-76), 6-4 | League Park II (25-25) | 73-63 | Lost 2 |
| » Starters: Joe Cascarella vs Mel Harder | Third | 15 out |
| Wednesday, September 12 |
| » Defeated Athletics (57-77), 3-2 | League Park II (26-25) | 74-63 | |
| » Starters: Bill Dietrich vs Willis Hudlin | Third | 14 out |
| Thursday, September 13 |
| » Lost to Yankees (86-53), 3-1 | League Park II (26-26) | 74-64 | |
| » Starters: Lefty Gomez vs Oral Hildebrand | Third | 15 out |
| Friday, September 14 |
| » Defeated Yankees (86-54), 12-5 | League Park II (27-26) | 75-64 | |
| » Starters: Red Ruffing vs Thornton Lee | Third | 15 out |
| Saturday, September 15 |
| » Lost to Yankees (87-54), 2-1 | League Park II (27-27) | 75-65 | |
| » Starters: Johnny Murphy vs Monte Pearson | Third | 16 out |
| Sunday, September 16 |
| » Defeated Yankees (87-55), 5-2 | Cleveland Stadium (14-0) | 76-65 | |
| » Starters: Johnny Broaca vs Mel Harder | Third | 16 out |
| Monday, September 17 |
| » Lost to Senators (62-78), 13-6 | League Park II (27-28) | 76-66 | |
| » Starters: Reese Diggs vs Oral Hildebrand | Third | 17 out |
| Tuesday, September 18 |
| » Defeated Senators (62-79), 5-4 | League Park II (28-28) | 77-66 | |
| » Starters: Lefty Stewart vs Thornton Lee | Third | 16½ out |
| » Defeated Senators (62-80), 9-6 | League Park II (29-28) | 78-66 | Won 2 |
| » Starters: Tommy Thomas vs Lloyd Brown | Third | 16½ out |
| » Major-league debuts: Syd Cohen (Senators) |
| Wednesday, September 19 |
| » Lost to Senators (63-80), 5-2 | League Park II (29-29) | 78-67 | |
| » Starters: Bobby Burke vs Monte Pearson | Third | 16½ out |
| Thursday, September 20 |
| » Defeated Senators (63-81), 6-1 | League Park II (30-29) | 79-67 | |
| » Starters: Syd Cohen vs Mel Harder | Third | 15½ out |
| Saturday, September 22 |
| » Defeated White Sox (51-93), 9-8 | Comiskey Park I (5-4) | 80-67 | Won 2 |
| » Starters: Oral Hildebrand vs Hugo Klaerner | Third | 16 out |
| Future Indian Lou Johnson is born in Lexington, KY. |
| Sunday, September 23 |
| » Defeated White Sox (51-94), 2-1 | Comiskey Park I (6-4) | 81-67 | Won 3 |
| » Starters: Monte Pearson vs Vern Kennedy | Third | 15 out |
| » Defeated White Sox (51-95), 5-1 | Comiskey Park I (7-4) | 82-67 | Won 4 |
| » Starters: Ralph Winegarner vs Les Tietje | Third | 15 out |
| Tuesday, September 25 |
| » Lost to Browns (67-82), 3-0 | League Park II (30-30) | 82-68 | |
| » Starters: Bump Hadley vs Mel Harder | Third | 15½ out |
| Wednesday, September 26 |
| » Defeated Browns (67-83), 6-2 | League Park II (31-30) | 83-68 | |
| » Starters: Bobo Newsom vs Willis Hudlin | Third | 16 out |
| Saturday, September 29 |
| » Defeated White Sox (52-98), 4-0 | League Park II (32-30) | 84-68 | Won 2 |
| » Starters: Les Tietje vs Mel Harder | Third | 15 out |
| Sunday, September 30 |
| » Lost to White Sox (53-98), 9-5 | Cleveland Stadium (14-1) | 84-69 | |
| » Starters: Ted Lyons vs Bill Perrin | Third | 16 out |
| » Defeated White Sox (53-99), 5-3 | Cleveland Stadium (15-1) | 85-69 | |
| » Starters: Vern Kennedy vs Ralph Winegarner | Third | 16 out |
| Thursday, October 18 |
| Former Indian Guy Morton dies in Sheffield, AL at the age of 42. |
| Tuesday, December 11 |
| Future Indian Lee Maye is born in Tuscaloosa, AL. |
Game information provided by Retrosheet (www.retrosheet.org) |
