| Sunday, January 8 |
| Future Indian Willie Tasby is born in Shreveport, LA. |
| Tuesday, January 17 |
| Future Indian J.W. Porter is born in Shawnee, OK. |
| Thursday, January 19 |
| Former Indian Harry Hinchman dies in Toledo, OH at the age of 55. |
| Friday, February 10 |
| Future Indian Russ Heman is born in Olive, CA. |
| Monday, February 27 |
| Future Indian Sammy Taylor is born in Woodruff, SC. |
| Monday, March 6 |
| Future Indian Ted Abernathy is born in Stanley, NC. |
| Saturday, March 11 |
| Future Indian Jack Spring is born in Spokane, WA. |
| Wednesday, April 12 |
| » Defeated Tigers (0-1), 4-1 | Tiger Stadium (1-0) | 1-0 | |
| » Starters: Clint Brown vs Tommy Bridges | First | -- |
| » Major-league debuts: Pete Fox (Tigers) Bill Knickerbocker (Indians) |
| Thursday, April 13 |
| » Defeated Tigers (0-2), 7-4 | Tiger Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Oral Hildebrand vs Firpo Marberry | First | -- |
| » Major-league debuts: Frank Reiber (Tigers) |
| Saturday, April 15 |
| » Major-league debuts: Schoolboy Rowe (Tigers) |
| Sunday, April 16 |
| » Defeated Browns (0-3), 7-1 | Sportsman's Park III (1-0) | 3-0 | Won 3 |
| » Starters: Wes Ferrell vs Lloyd Brown | Second | ½ out |
| Monday, April 17 |
| » Lost to Browns (1-3), 4-3 | Sportsman's Park III (1-1) | 3-1 | |
| » Starters: Willis Hudlin vs Bump Hadley | Second | 1 out |
| Tuesday, April 18 |
| » Lost to Browns (2-3), 1-0 | Sportsman's Park III (1-2) | 3-2 | Lost 2 |
| » Starters: Mel Harder vs George Blaeholder | Second | 2 out |
| Thursday, April 20 |
| » Defeated Tigers (2-4), 3-1 | Cleveland Stadium (1-0) | 4-2 | |
| » Starters: Vic Sorrell vs Clint Brown | Third | 1½ out |
| Friday, April 21 |
| » Defeated Tigers (2-5), 5-0 | Cleveland Stadium (2-0) | 5-2 | Won 2 |
| » Starters: Schoolboy Rowe vs Oral Hildebrand | Second | 1½ out |
| Saturday, April 22 |
| » Lost to White Sox (6-3), 3-1 | Comiskey Park I (0-1) | 5-3 | |
| » Starters: Willis Hudlin vs Milt Gaston | Third | 2½ out |
| Sunday, April 23 |
| » Lost to White Sox (7-3), 4-1 | Comiskey Park I (0-2) | 5-4 | Lost 2 |
| » Starters: Mel Harder vs Ted Lyons | Third | 2½ out |
| Monday, April 24 |
| » Lost to White Sox (8-3), 5-4 | Comiskey Park I (0-3) | 5-5 | Lost 3 |
| » Starters: Wes Ferrell vs Vic Frasier | Fourth | 2½ out |
| Tuesday, April 25 |
| » Defeated Browns (3-9), 4-1 | Cleveland Stadium (3-0) | 6-5 | |
| » Starters: Bump Hadley vs Clint Brown | Third | 2½ out |
| Wednesday, April 26 |
| » Defeated Browns (3-10), 2-0 | Cleveland Stadium (4-0) | 7-5 | Won 2 |
| » Starters: Lloyd Brown vs Oral Hildebrand | Third | 2 out |
| Thursday, April 27 |
| » Lost to Browns (4-10), 3-2 | Cleveland Stadium (4-1) | 7-6 | |
| » Starters: George Blaeholder vs Mel Harder | Third | 3 out |
| Friday, April 28 |
| » Defeated White Sox (9-5), 5-1 | Cleveland Stadium (5-1) | 8-6 | |
| » Starters: Milt Gaston vs Sarge Connally | Third | 2 out |
| Saturday, April 29 |
| » Defeated White Sox (9-6), 4-1 | Cleveland Stadium (6-1) | 9-6 | Won 2 |
| » Starters: Ted Lyons vs Wes Ferrell | Second | 1 out |
| Sunday, April 30 |
| » Lost to White Sox (10-6), 3-1 | Cleveland Stadium (6-2) | 9-7 | |
| » Starters: Paul Gregory vs Clint Brown | Third | 2½ out |
| Monday, May 1 |
| » Defeated White Sox (10-7), 8-1 | Cleveland Stadium (7-2) | 10-7 | |
| » Starters: Ed Durham vs Oral Hildebrand | Third | 2 out |
| Thursday, May 4 |
| » Defeated Senators (10-7), 6-5 | Cleveland Stadium (8-2) | 11-7 | Won 2 |
| » Starters: General Crowder vs Mel Harder | Second | 1½ out |
| Saturday, May 6 |
| » Defeated Yankees (12-6), 7-6 | Cleveland Stadium (9-2) | 12-7 | Won 3 |
| » Starters: George Pipgras vs Wes Ferrell | Second | ½ out |
| Sunday, May 7 |
| » Defeated Yankees (12-7), 7-6 | Cleveland Stadium (10-2) | 13-7 | Won 4 |
| » Starters: Russ Van Atta vs Oral Hildebrand | Second | ½ out |
| » Lost to Yankees (13-7), 8-4 | Cleveland Stadium (10-3) | 13-8 | |
| » Starters: Red Ruffing vs Clint Brown | Second | ½ out |
| Wednesday, May 10 |
| » Defeated Red Sox (6-14), 4-2 | Cleveland Stadium (11-3) | 14-8 | |
| » Starters: Bob Weiland vs Willis Hudlin | First | -- |
| Thursday, May 11 |
| » Defeated Red Sox (6-15), 4-1 | Cleveland Stadium (12-3) | 15-8 | Won 2 |
| » Starters: Ivy Andrews vs Mel Harder | First | -- |
| Friday, May 12 |
| » Lost to Athletics (10-11), 7-3 | Cleveland Stadium (12-4) | 15-9 | |
| » Starters: Roy Mahaffey vs Wes Ferrell | Second | 1 out |
| Sunday, May 14 |
| » Defeated Athletics (10-12), 3-0 | Cleveland Stadium (13-4) | 16-9 | |
| » Starters: Tony Freitas vs Oral Hildebrand | First | -- |
| » Defeated Athletics (10-13), 5-3 | Cleveland Stadium (14-4) | 17-9 | Won 2 |
| » Starters: Hank McDonald vs Clint Brown | First | -- |
| Monday, May 15 |
| » Lost to Athletics (11-13), 1-0 | Shibe Park (0-1) | 17-10 | |
| » Starters: Willis Hudlin vs Sugar Cain | First | -- |
| Tuesday, May 16 |
| » Lost to Senators (17-11), 11-10 | Griffith Stadium (0-1) | 17-11 | Lost 2 |
| » Starters: Belve Bean vs Lefty Stewart | Second | 2 out |
| » Major-league debuts: Cecil Travis (Senators) |
| Wednesday, May 17 |
| » Lost to Senators (18-11), 3-2 | Griffith Stadium (0-2) | 17-12 | Lost 3 |
| » Starters: Wes Ferrell vs General Crowder | Third | 2 out |
| Thursday, May 18 |
| » Defeated Senators (18-12), 6-5 | Griffith Stadium (1-2) | 18-12 | |
| » Starters: Oral Hildebrand vs Earl Whitehill | Second | 2 out |
| Future Indian Carroll Hardy is born in Sturgis, SD. |
| Friday, May 19 |
| » Lost to Athletics (13-14), 9-2 | Shibe Park (0-2) | 18-13 | |
| » Starters: Clint Brown vs Roy Mahaffey | Second | 2 out |
| Saturday, May 20 |
| » Lost to Athletics (14-14), 7-2 | Shibe Park (0-3) | 18-14 | Lost 2 |
| » Starters: Willis Hudlin vs Sugar Cain | Third | 2 out |
| Monday, May 22 |
| » Lost to Yankees (19-11), 3-0 | Yankee Stadium (0-1) | 18-15 | Lost 3 |
| » Starters: Wes Ferrell vs Lefty Gomez | Fourth | 2½ out |
| Tuesday, May 23 |
| » Lost to Yankees (20-11), 8-6 | Yankee Stadium (0-2) | 18-16 | Lost 4 |
| » Starters: Oral Hildebrand vs Johnny Allen | Fifth | 3½ out |
| Thursday, May 25 |
| » Defeated Red Sox (11-21), 3-2 | Fenway Park (1-0) | 19-16 | |
| » Starters: Mel Harder vs Gordon Rhodes | Fourth | 3 out |
| Friday, May 26 |
| » Lost to Red Sox (12-21), 6-5 | Fenway Park (1-1) | 19-17 | |
| » Starters: Clint Brown vs Hank Johnson | Fifth | 3 out |
| Saturday, May 27 |
| » Defeated Red Sox (12-22), 6-0 | Fenway Park (2-1) | 20-17 | |
| » Starters: Wes Ferrell vs Lloyd Brown | Fourth | 3 out |
| Sunday, May 28 |
| » Lost to Red Sox (13-22), 5-2 | Fenway Park (2-2) | 20-18 | |
| » Starters: Oral Hildebrand vs Bob Weiland | Fourth | 4 out |
| » Defeated Red Sox (13-23), 11-2 | Fenway Park (3-2) | 21-18 | |
| » Starters: Willis Hudlin vs Ivy Andrews | Fourth | 4 out |
| Tuesday, May 30 |
| » Lost to White Sox (20-17), 7-2 | Comiskey Park I (0-4) | 21-19 | |
| » Starters: Mel Harder vs Ed Durham | Fourth | 4½ out |
| » Defeated White Sox (20-18), 15-8 | Comiskey Park I (1-4) | 22-19 | |
| » Starters: Clint Brown vs Paul Gregory | Fourth | 4½ out |
| Thursday, June 1 |
| » Defeated Browns (16-26), 3-1 | Sportsman's Park III (2-2) | 23-19 | Won 2 |
| » Starters: Wes Ferrell vs Hank McDonald | Fourth | 4 out |
| Friday, June 2 |
| » Defeated Browns (16-27), 2-1 | Sportsman's Park III (3-2) | 24-19 | Won 3 |
| » Starters: Oral Hildebrand vs George Blaeholder | Second | 3½ out |
| » Defeated Browns (16-28), 1-0 | Sportsman's Park III (4-2) | 25-19 | Won 4 |
| » Starters: Mel Harder vs Bump Hadley | Second | 3½ out |
| Saturday, June 3 |
| » Lost to Browns (17-28), 8-5 | Sportsman's Park III (4-3) | 25-20 | |
| » Starters: Willis Hudlin vs Wally Hebert | Third | 4½ out |
| Sunday, June 4 |
| » Defeated Tigers (18-25), 2-1 | Cleveland Stadium (15-4) | 26-20 | |
| » Starters: Carl Fischer vs Clint Brown | Third | 5½ out |
| » Lost to Tigers (19-25), 4-3 | Cleveland Stadium (15-5) | 26-21 | |
| » Starters: Firpo Marberry vs Willis Hudlin | Third | 5½ out |
| Monday, June 5 |
| » Lost to Tigers (20-25), 8-7 | Cleveland Stadium (15-6) | 26-22 | Lost 2 |
| » Starters: Vic Frasier vs Wes Ferrell | Fourth | 6 out |
| Tuesday, June 6 |
| » Lost to Tigers (21-25), 5-2 | Cleveland Stadium (15-7) | 26-23 | Lost 3 |
| » Starters: Schoolboy Rowe vs Mel Harder | Fifth | 7½ out |
| Wednesday, June 7 |
| » Lost to Tigers (22-25), 3-1 | Cleveland Stadium (15-8) | 26-24 | Lost 4 |
| » Starters: Tommy Bridges vs Oral Hildebrand | Fifth | 8 out |
| Future Indian Herb Score is born in Rosedale, NY. |
| Thursday, June 8 |
| » Lost to Browns (18-33), 5-3 | Cleveland Stadium (15-9) | 26-25 | Lost 5 |
| » Starters: Ed Wells vs Clint Brown | Fifth | 8 out |
| Saturday, June 10 |
| » Defeated Browns (18-34), 5-2 | Cleveland Stadium (16-9) | 27-25 | |
| » Manager: Bibb Falk |
| » Starters: George Blaeholder vs Wes Ferrell | Fifth | 7 out |
| Former Indian Jack O'Brien dies in Watervliet, NY at the age of 61. |
| Sunday, June 11 |
| » Defeated Browns (18-35), 1-0 | Cleveland Stadium (17-9) | 28-25 | Won 2 |
| » Manager: Walter Johnson |
| » Starters: Bump Hadley vs Mel Harder | Fifth | 6½ out |
| Tuesday, June 13 |
| » Defeated Tigers (25-28), 1-0 | Tiger Stadium (3-0) | 29-25 | Won 3 |
| » Starters: Oral Hildebrand vs Tommy Bridges | Fourth | 5½ out |
| Wednesday, June 14 |
| » Lost to Tigers (26-28), 13-2 | Tiger Stadium (3-1) | 29-26 | |
| » Starters: Clint Brown vs Firpo Marberry | Fifth | 5½ out |
| Saturday, June 17 |
| » Defeated Tigers (26-29), 3-2 | Cleveland Stadium (18-9) | 30-26 | |
| » Starters: Tommy Bridges vs Wes Ferrell | Third | 5 out |
| Sunday, June 18 |
| » Defeated Red Sox (20-36), 7-0 | Cleveland Stadium (19-9) | 31-26 | Won 2 |
| » Starters: Lloyd Brown vs Oral Hildebrand | Third | 4 out |
| » Defeated Red Sox (20-37), 4-0 | Cleveland Stadium (20-9) | 32-26 | Won 3 |
| » Starters: Bob Weiland vs Mel Harder | Third | 4 out |
| Monday, June 19 |
| » Lost to Red Sox (21-37), 5-2 | Cleveland Stadium (20-10) | 32-27 | |
| » Starters: George Pipgras vs Clint Brown | Third | 4 out |
| Tuesday, June 20 |
| » Lost to Red Sox (22-37), 9-5 | Cleveland Stadium (20-11) | 32-28 | Lost 2 |
| » Starters: Hank Johnson vs Sarge Connally | Third | 5 out |
| Wednesday, June 21 |
| » Defeated Athletics (28-28), 11-1 | Cleveland Stadium (21-11) | 33-28 | |
| » Starters: George Earnshaw vs Wes Ferrell | Third | 5 out |
| Thursday, June 22 |
| » Lost to Athletics (29-28), 11-6 | Cleveland Stadium (21-12) | 33-29 | |
| » Starters: Sugar Cain vs Oral Hildebrand | Second | 5 out |
| Friday, June 23 |
| » Lost to Athletics (30-28), 8-4 | Cleveland Stadium (21-13) | 33-30 | Lost 2 |
| » Starters: Roy Mahaffey vs Mel Harder | Third | 6 out |
| Saturday, June 24 |
| » Lost to Athletics (31-28), 6-2 | Cleveland Stadium (21-14) | 33-31 | Lost 3 |
| » Starters: Lefty Grove vs Willis Hudlin | Fourth | 7 out |
| Sunday, June 25 |
| » Lost to Senators (40-23), 9-0 | Cleveland Stadium (21-15) | 33-32 | Lost 4 |
| » Starters: Earl Whitehill vs Wes Ferrell | Fourth | 9 out |
| » Lost to Senators (41-23), 10-1 | Cleveland Stadium (21-16) | 33-33 | Lost 5 |
| » Starters: Bobby Burke vs Belve Bean | Fourth | 9 out |
| » Major-league debuts: Milt Galatzer (Indians) |
| Monday, June 26 |
| » Lost to Senators (42-23), 4-3 | Cleveland Stadium (21-17) | 33-34 | Lost 6 |
| » Starters: General Crowder vs Oral Hildebrand | Fourth | 10 out |
| Future Indian Gene Green is born in Los Angeles, CA. |
| Tuesday, June 27 |
| » Defeated Senators (42-24), 7-6 | Cleveland Stadium (22-17) | 34-34 | |
| » Starters: Tommy Thomas vs Mel Harder | Fourth | 9 out |
| Wednesday, June 28 |
| » Lost to Senators (43-24), 15-2 | Cleveland Stadium (22-18) | 34-35 | |
| » Starters: Lefty Stewart vs Wes Ferrell | Fifth | 10 out |
| Thursday, June 29 |
| » Lost to Yankees (43-25), 9-3 | Cleveland Stadium (22-19) | 34-36 | Lost 2 |
| » Starters: Lefty Gomez vs Willis Hudlin | Fourth | 10 out |
| Friday, June 30 |
| » Defeated Yankees (43-26), 13-12 | Cleveland Stadium (23-19) | 35-36 | |
| » Starters: Russ Van Atta vs Oral Hildebrand | Fifth | 10 out |
| Saturday, July 1 |
| » Lost to Yankees (44-26), 4-2 | Cleveland Stadium (23-20) | 35-37 | |
| » Starters: Johnny Allen vs Wes Ferrell | Fifth | 11 out |
| Sunday, July 2 |
| » Lost to Yankees (45-26), 7-3 | Cleveland Stadium (23-21) | 35-38 | Lost 2 |
| » Starters: Jumbo Brown vs Mel Harder | Fifth | 11½ out |
| Monday, July 3 |
| » Defeated White Sox (34-37), 5-2 | Cleveland Stadium (24-21) | 36-38 | |
| » Starters: Ed Durham vs Oral Hildebrand | Fourth | 11 out |
| Tuesday, July 4 |
| » Defeated White Sox (34-38), 5-2 | Cleveland Stadium (25-21) | 37-38 | Won 2 |
| » Starters: Milt Gaston vs Willis Hudlin | Fourth | 12 out |
| » Lost to White Sox (35-38), 6-3 | Cleveland Stadium (25-22) | 37-39 | |
| » Starters: Whit Wyatt vs Sarge Connally | Fourth | 12 out |
| Wednesday, July 5 |
| » Lost to White Sox (36-38), 10-6 | Cleveland Stadium (25-23) | 37-40 | Lost 2 |
| » Starters: Chad Kimsey vs Mel Harder | Fifth | 12½ out |
| Saturday, July 8 |
| » Lost to Senators (48-25), 6-2 | Griffith Stadium (1-3) | 37-41 | Lost 3 |
| » Starters: Wes Ferrell vs General Crowder | Fifth | 14½ out |
| » Lost to Senators (49-25), 5-4 | Griffith Stadium (1-4) | 37-42 | Lost 4 |
| » Starters: Oral Hildebrand vs Earl Whitehill | Fifth | 14½ out |
| Sunday, July 9 |
| » Lost to Senators (50-25), 3-2 | Griffith Stadium (1-5) | 37-43 | Lost 5 |
| » Starters: Monte Pearson vs Tommy Thomas | Sixth | 15½ out |
| Monday, July 10 |
| » Defeated Senators (50-26), 3-2 | Griffith Stadium (2-5) | 38-43 | |
| » Starters: Mel Harder vs Lefty Stewart | Sixth | 14½ out |
| Tuesday, July 11 |
| » Lost to Athletics (40-39), 6-4 | Shibe Park (0-4) | 38-44 | |
| » Starters: Clint Brown vs Roy Mahaffey | Sixth | 14½ out |
| Wednesday, July 12 |
| » Lost to Athletics (41-39), 6-4 | Shibe Park (0-5) | 38-45 | Lost 2 |
| » Starters: Oral Hildebrand vs Rube Walberg | Sixth | 15½ out |
| Thursday, July 13 |
| » Defeated Athletics (41-40), 6-5 | Shibe Park (1-5) | 39-45 | |
| » Starters: Monte Pearson vs Sugar Cain | Sixth | 14½ out |
| Friday, July 14 |
| » Lost to Athletics (42-40), 3-2 | Shibe Park (1-6) | 39-46 | |
| » Starters: Wes Ferrell vs Dick Barrett | Sixth | 14½ out |
| Saturday, July 15 |
| » Lost to Red Sox (35-47), 7-2 | Fenway Park (3-3) | 39-47 | Lost 2 |
| » Starters: Mel Harder vs Gordon Rhodes | Sixth | 16 out |
| Sunday, July 16 |
| » Defeated Red Sox (35-48), 2-1 | Fenway Park (4-3) | 40-47 | |
| » Starters: Willis Hudlin vs Bob Weiland | Fifth | 15 out |
| Tuesday, July 18 |
| » Defeated Red Sox (35-49), 2-1 | Fenway Park (5-3) | 41-47 | Won 2 |
| » Starters: Monte Pearson vs Lloyd Brown | Sixth | 15 out |
| Wednesday, July 19 |
| » Defeated Red Sox (35-50), 8-7 | Fenway Park (6-3) | 42-47 | Won 3 |
| » Starters: Wes Ferrell vs Hank Johnson | Fifth | 14 out |
| Thursday, July 20 |
| » Defeated Yankees (54-32), 3-1 | Yankee Stadium (1-2) | 43-47 | Won 4 |
| » Starters: Mel Harder vs Lefty Gomez | Fifth | 13 out |
| Friday, July 21 |
| » Lost to Yankees (55-32), 10-2 | Yankee Stadium (1-3) | 43-48 | |
| » Starters: Willis Hudlin vs Russ Van Atta | Fifth | 14 out |
| Saturday, July 22 |
| » Defeated Yankees (55-33), 2-1 | Yankee Stadium (2-3) | 44-48 | |
| » Starters: Monte Pearson vs Red Ruffing | Fifth | 14 out |
| Sunday, July 23 |
| » Lost to Yankees (56-33), 8-1 | Yankee Stadium (2-4) | 44-49 | |
| » Starters: Wes Ferrell vs Johnny Allen | Sixth | 15 out |
| » Lost to Yankees (57-33), 8-1 | Yankee Stadium (2-5) | 44-50 | Lost 2 |
| » Starters: Oral Hildebrand vs Danny MacFayden | Sixth | 15 out |
| Former Indian Rip Williams dies in Keokuk, IA at the age of 52. |
| Tuesday, July 25 |
| » Defeated White Sox (43-49), 2-1 | Comiskey Park I (2-4) | 45-50 | |
| » Starters: Mel Harder vs Sad Sam Jones | Fifth | 15½ out |
| Wednesday, July 26 |
| » Defeated White Sox (43-50), 7-1 | Comiskey Park I (3-4) | 46-50 | Won 2 |
| » Starters: Willis Hudlin vs Joe Heving | Fifth | 15 out |
| Thursday, July 27 |
| » Defeated White Sox (43-51), 9-1 | Comiskey Park I (4-4) | 47-50 | Won 3 |
| » Starters: Monte Pearson vs Milt Gaston | Fourth | 15 out |
| Friday, July 28 |
| » Defeated Tigers (46-50), 7-2 | Cleveland Stadium (26-23) | 48-50 | Won 4 |
| » Starters: Vic Sorrell vs Oral Hildebrand | Fourth | 14½ out |
| » Major-league debuts: Johnny Pasek (Tigers) |
| Saturday, July 29 |
| » Defeated Tigers (46-51), 1-0 | Cleveland Stadium (27-23) | 49-50 | Won 5 |
| » Starters: Carl Fischer vs Clint Brown | Fourth | 14½ out |
| Sunday, July 30 |
| » Lost to Tigers (47-51), 6-1 | Cleveland Stadium (27-24) | 49-51 | |
| » Starters: Tommy Bridges vs Mel Harder | Fourth | 14½ out |
| Monday, July 31 |
| » Lost to Browns (38-65), 12-8 | Sportsman's Park III (4-4) | 49-52 | Lost 2 |
| » Starters: Willis Hudlin vs Ed Wells | Fourth | 14½ out |
| Tuesday, August 1 |
| » Lost to Browns (39-65), 5-2 | Sportsman's Park III (4-5) | 49-53 | Lost 3 |
| » Starters: Monte Pearson vs Sam Gray | Fifth | 15 out |
| Wednesday, August 2 |
| » Defeated Browns (39-66), 16-8 | Sportsman's Park III (5-5) | 50-53 | |
| » Starters: Wes Ferrell vs George Blaeholder | Fourth | 15 out |
| Thursday, August 3 |
| » Defeated Browns (39-67), 7-2 | Sportsman's Park III (6-5) | 51-53 | Won 2 |
| » Starters: Mel Harder vs Ed Wells | Fourth | 15 out |
| Saturday, August 5 |
| » Defeated Tigers (48-54), 15-6 | Tiger Stadium (4-1) | 52-53 | Won 3 |
| » Starters: Clint Brown vs Tommy Bridges | Fourth | 15½ out |
| » Lost to Tigers (49-54), 7-1 | Tiger Stadium (4-2) | 52-54 | |
| » Starters: Willis Hudlin vs Carl Fischer | Fourth | 15½ out |
| Sunday, August 6 |
| » Lost to Tigers (50-54), 7-3 | Tiger Stadium (4-3) | 52-55 | Lost 2 |
| » Starters: Oral Hildebrand vs Vic Frasier | Fifth | 16 out |
| » Lost to Tigers (51-54), 2-1 | Tiger Stadium (4-4) | 52-56 | Lost 3 |
| » Starters: Monte Pearson vs Firpo Marberry | Fifth | 16 out |
| Monday, August 7 |
| » Lost to Tigers (52-54), 6-3 | Tiger Stadium (4-5) | 52-57 | Lost 4 |
| » Starters: Mel Harder vs Vic Sorrell | Fifth | 15½ out |
| Thursday, August 10 |
| Future Indian Rocky Colavito is born in New York, NY. |
| Saturday, August 12 |
| » Defeated Browns (42-69), 4-3 | Cleveland Stadium (28-24) | 53-57 | |
| » Starters: Ed Wells vs Oral Hildebrand | Fourth | 17½ out |
| Sunday, August 13 |
| » Defeated Browns (42-70), 5-3 | Cleveland Stadium (29-24) | 54-57 | Won 2 |
| » Starters: Bump Hadley vs Mel Harder | Fourth | 17 out |
| » Defeated Browns (42-71), 3-2 | Cleveland Stadium (30-24) | 55-57 | Won 3 |
| » Starters: George Blaeholder vs Monte Pearson | Fourth | 17 out |
| Monday, August 14 |
| » Lost to Athletics (54-53), 11-5 | Cleveland Stadium (30-25) | 55-58 | |
| » Starters: Roy Mahaffey vs Willis Hudlin | Fourth | 17½ out |
| Tuesday, August 15 |
| » Lost to Athletics (55-53), 8-7 | Cleveland Stadium (30-26) | 55-59 | Lost 2 |
| » Starters: Lefty Grove vs Wes Ferrell | Fifth | 18½ out |
| Wednesday, August 16 |
| » Defeated Athletics (55-54), 5-4 | Cleveland Stadium (31-26) | 56-59 | |
| » Starters: Sugar Cain vs Oral Hildebrand | Fifth | 18½ out |
| Thursday, August 17 |
| » Defeated Athletics (55-55), 15-4 | Cleveland Stadium (32-26) | 57-59 | Won 2 |
| » Starters: George Earnshaw vs Monte Pearson | Fourth | 18½ out |
| Friday, August 18 |
| » Defeated Red Sox (49-62), 2-1 | Cleveland Stadium (33-26) | 58-59 | Won 3 |
| » Starters: Gordon Rhodes vs Mel Harder | Third | 18½ out |
| Saturday, August 19 |
| » Defeated Red Sox (49-63), 6-5 | Cleveland Stadium (34-26) | 59-59 | Won 4 |
| » Starters: Ivy Andrews vs Clint Brown | Third | 18½ out |
| Sunday, August 20 |
| » Defeated Red Sox (49-64), 14-6 | Cleveland Stadium (35-26) | 60-59 | Won 5 |
| » Starters: Hank Johnson vs Oral Hildebrand | Third | 18½ out |
| » Defeated Red Sox (49-65), 9-4 | Cleveland Stadium (36-26) | 61-59 | Won 6 |
| » Starters: Bob Kline vs Wes Ferrell | Third | 18½ out |
| Monday, August 21 |
| » Defeated Red Sox (49-66), 10-1 | Cleveland Stadium (37-26) | 62-59 | Won 7 |
| » Starters: Bob Weiland vs Monte Pearson | Third | 18 out |
| Tuesday, August 22 |
| » Lost to Yankees (69-46), 4-3 | Cleveland Stadium (37-27) | 62-60 | |
| » Starters: Lefty Gomez vs Mel Harder | Third | 18 out |
| Wednesday, August 23 |
| » Defeated Yankees (69-47), 2-1 | Cleveland Stadium (38-27) | 63-60 | |
| » Starters: Red Ruffing vs Clint Brown | Third | 17½ out |
| Thursday, August 24 |
| » Lost to Yankees (70-47), 10-1 | Cleveland Stadium (38-28) | 63-61 | |
| » Starters: Johnny Allen vs Oral Hildebrand | Third | 18½ out |
| Friday, August 25 |
| » Defeated Yankees (70-48), 6-4 | Cleveland Stadium (39-28) | 64-61 | |
| » Starters: Charlie Devens vs Monte Pearson | Third | 18½ out |
| Saturday, August 26 |
| » Defeated Senators (80-41), 5-4 | Cleveland Stadium (40-28) | 65-61 | Won 2 |
| » Starters: Monte Weaver vs Wes Ferrell | Third | 17½ out |
| Sunday, August 27 |
| » Lost to Senators (81-41), 14-1 | Cleveland Stadium (40-29) | 65-62 | |
| » Starters: Earl Whitehill vs Mel Harder | Third | 17½ out |
| » Defeated Senators (81-42), 6-3 | Cleveland Stadium (41-29) | 66-62 | |
| » Starters: General Crowder vs Clint Brown | Third | 17½ out |
| Tuesday, August 29 |
| » Lost to Senators (82-42), 2-1 | Cleveland Stadium (41-30) | 66-63 | |
| » Starters: Lefty Stewart vs Oral Hildebrand | Third | 17½ out |
| » Defeated Senators (82-43), 7-2 | Cleveland Stadium (42-30) | 67-63 | |
| » Starters: Bobby Burke vs Monte Pearson | Third | 17½ out |
| Thursday, August 31 |
| » Defeated White Sox (60-68), 4-1 | Comiskey Park I (5-4) | 68-63 | Won 2 |
| » Starters: Mel Harder vs Ted Lyons | Third | 17 out |
| Saturday, September 2 |
| » Defeated White Sox (60-69), 12-4 | Comiskey Park I (6-4) | 69-63 | Won 3 |
| » Starters: Monte Pearson vs Milt Gaston | Third | 16 out |
| Sunday, September 3 |
| » Defeated White Sox (60-70), 14-3 | Comiskey Park I (7-4) | 70-63 | Won 4 |
| » Starters: Wes Ferrell vs Joe Heving | Third | 16 out |
| » Major-league debuts: Milt Bocek (White Sox) |
| Monday, September 4 |
| » Defeated Browns (49-83), 3-2 | Cleveland Stadium (43-30) | 71-63 | Won 5 |
| » Starters: Ed Wells vs Oral Hildebrand | Third | 15 out |
| » Defeated Browns (49-84), 2-0 | Cleveland Stadium (44-30) | 72-63 | Won 6 |
| » Starters: Wally Hebert vs Clint Brown | Third | 15 out |
| Tuesday, September 5 |
| » Major-league debuts: Phil Weintraub (Giants) |
| Wednesday, September 6 |
| » Lost to Athletics (65-65), 5-4 | Shibe Park (1-7) | 72-64 | |
| » Starters: Mel Harder vs Lefty Grove | Third | 17 out |
| Thursday, September 7 |
| » Lost to Athletics (66-65), 6-0 | Shibe Park (1-8) | 72-65 | Lost 2 |
| » Starters: Monte Pearson vs Johnny Marcum | Third | 17 out |
| Friday, September 8 |
| » Lost to Athletics (67-65), 9-2 | Shibe Park (1-9) | 72-66 | Lost 3 |
| » Starters: Wes Ferrell vs Sugar Cain | Third | 18 out |
| Saturday, September 9 |
| » Lost to Athletics (68-65), 5-3 | Shibe Park (1-10) | 72-67 | Lost 4 |
| » Starters: Clint Brown vs Roy Mahaffey | Third | 19 out |
| Sunday, September 10 |
| » Lost to Senators (90-46), 7-3 | Griffith Stadium (2-6) | 72-68 | Lost 5 |
| » Starters: Oral Hildebrand vs Lefty Stewart | Third | 20 out |
| Monday, September 11 |
| » Lost to Senators (91-46), 5-1 | Griffith Stadium (2-7) | 72-69 | Lost 6 |
| » Starters: Mel Harder vs Monte Weaver | Fourth | 21 out |
| » Major-league debuts: Hal Trosky (Indians) |
| Tuesday, September 12 |
| » Defeated Senators (91-47), 3-1 | Griffith Stadium (3-7) | 73-69 | |
| » Starters: Monte Pearson vs General Crowder | Fourth | 20 out |
| Sunday, September 17 |
| » Lost to Yankees (82-54), 3-2 | Yankee Stadium (2-6) | 73-70 | |
| » Starters: Monte Pearson vs Russ Van Atta | Fourth | 23 out |
| » Lost to Yankees (83-54), 6-1 | Yankee Stadium (2-7) | 73-71 | Lost 2 |
| » Starters: Mel Harder vs Lefty Gomez | Fourth | 23 out |
| Monday, September 18 |
| » Defeated Red Sox (58-84), 9-0 | Fenway Park (7-3) | 74-71 | |
| » Starters: Oral Hildebrand vs Gordon Rhodes | Fourth | 22 out |
| Tuesday, September 19 |
| » Lost to Red Sox (59-84), 4-3 | Fenway Park (7-4) | 74-72 | |
| » Starters: Clint Brown vs Bob Weiland | Fourth | 22 out |
| » Major-league debuts: Thornton Lee (Indians) |
| Thursday, September 21 |
| » Major-league debuts: Frankie Hayes (Athletics) |
| Saturday, September 23 |
| » Lost to White Sox (64-82), 6-5 | Cleveland Stadium (44-31) | 74-73 | Lost 2 |
| » Starters: Les Tietje vs Mel Harder | Fourth | 23 out |
| Sunday, September 24 |
| » Lost to White Sox (65-82), 8-7 | Cleveland Stadium (44-32) | 74-74 | Lost 3 |
| » Starters: Ira Hutchinson vs Oral Hildebrand | Fourth | 22½ out |
| » Defeated White Sox (65-83), 12-6 | Cleveland Stadium (45-32) | 75-74 | |
| » Starters: Paul Gregory vs Thornton Lee | Fourth | 22½ out |
| » Major-league debuts: Ira Hutchinson (White Sox) |
| Saturday, September 30 |
| » Lost to Tigers (74-79), 3-0 | Tiger Stadium (4-6) | 75-75 | |
| » Starters: Thornton Lee vs Elden Auker | Fourth | 23½ out |
| Sunday, October 1 |
| » Lost to Tigers (75-79), 5-3 | Tiger Stadium (4-7) | 75-76 | Lost 2 |
| » Starters: Clint Brown vs Luke Hamlin | Fourth | 23½ out |
| Monday, October 23 |
| Future Indian Jake Striker is born in New Washington, OH. |
| Saturday, November 4 |
| Future Indian Tito Francona is born in Aliquippa, PA. |
| Tuesday, November 7 |
| Future Indian Bob Hale is born in Sarasota, FL. |
| Friday, November 17 |
| Future Indian Orlando Pena is born in Victoria De Las Tunas, Cuba. |
| Monday, November 27 |
| Future Indian Billy Moran is born in Montgomery, AL. |
| Wednesday, November 29 |
| Former Indian John Humphries dies in Salinas, CA at the age of 73. |
| Wednesday, December 27 |
| Former Indian Fritz Buelow dies in Detroit, MI at the age of 58. |
Game information provided by Retrosheet (www.retrosheet.org) |
