| Tuesday, April 14 |
| » Defeated Senators (0-1), 5-3 | Griffith Stadium (1-0) | 1-0 | |
| » Starters: Rube Walberg vs Lloyd Brown | First | -- |
| Wednesday, April 15 |
| » Lost to Senators (1-1), 7-1 | Griffith Stadium (1-1) | 1-1 | |
| » Starters: George Earnshaw vs Bump Hadley | Second | 1 out |
| Thursday, April 16 |
| » Lost to Senators (2-1), 5-4 | Griffith Stadium (1-2) | 1-2 | Lost 2 |
| » Starters: Hank McDonald vs Alvin Crowder | Third | 2 out |
| Saturday, April 18 |
| » Lost to Senators (3-1), 2-1 | Griffith Stadium (1-3) | 1-3 | Lost 3 |
| » Starters: Lefty Grove vs Sam Jones | Second | 2 out |
| Sunday, April 19 |
| » Defeated Yankees (3-2), 3-2 | Yankee Stadium (1-0) | 2-3 | |
| » Starters: Rube Walberg vs Red Ruffing | Third | 2 out |
| Monday, April 20 |
| » Lost to Yankees (4-2), 5-4 | Yankee Stadium (1-1) | 2-4 | |
| » Starters: George Earnshaw vs Hank Johnson | Fourth | 2 out |
| Tuesday, April 21 |
| » Lost to Yankees (5-2), 12-1 | Yankee Stadium (1-2) | 2-5 | Lost 2 |
| » Starters: Roy Mahaffey vs Herb Pennock | Fourth | 3 out |
| Wednesday, April 22 |
| » Defeated Senators (5-3), 5-1 | Shibe Park (1-0) | 3-5 | |
| » Starters: Bump Hadley vs Lefty Grove | Fifth | 3 out |
| Friday, April 24 |
| » Defeated Senators (5-4), 10-7 | Shibe Park (2-0) | 4-5 | Won 2 |
| » Starters: Sam Jones vs Hank McDonald | Fourth | 3 out |
| Saturday, April 25 |
| » Defeated Senators (5-5), 3-2 | Shibe Park (3-0) | 5-5 | Won 3 |
| » Starters: Lloyd Brown vs Rube Walberg | Second | 2 out |
| Tuesday, April 28 |
| » Major-league debuts: Dixie Walker (Yankees) |
| Thursday, April 30 |
| » Lost to Yankees (8-6), 7-2 | Shibe Park (3-1) | 5-6 | |
| » Starters: Hank Johnson vs Rube Walberg | Sixth | 3 out |
| Friday, May 1 |
| » Defeated Yankees (8-7), 4-0 | Shibe Park (4-1) | 6-6 | |
| » Starters: George Pipgras vs George Earnshaw | Fifth | 2 out |
| Sunday, May 3 |
| » Defeated Senators (9-8), 3-1 | Griffith Stadium (2-3) | 7-6 | Won 2 |
| » Starters: Rube Walberg vs Lloyd Brown | Third | 2½ out |
| Monday, May 4 |
| » Lost to Red Sox (6-9), 7-5 | Shibe Park (4-2) | 7-7 | |
| » Starters: Milt Gaston vs Hank McDonald | Fourth | 2½ out |
| Tuesday, May 5 |
| » Defeated Red Sox (6-10), 4-1 | Shibe Park (5-2) | 8-7 | |
| » Starters: Ed Durham vs George Earnshaw | Third | 2½ out |
| Wednesday, May 6 |
| » Defeated Red Sox (6-11), 10-3 | Shibe Park (6-2) | 9-7 | Won 2 |
| » Starters: Jack Russell vs Eddie Rommel | Third | 2 out |
| Saturday, May 9 |
| » Defeated Browns (6-12), 6-4 | Sportsman's Park III (1-0) | 10-7 | Won 3 |
| » Starters: Rube Walberg vs Dolly Gray | Second | 1½ out |
| Tuesday, May 12 |
| » Defeated White Sox (9-12), 5-2 | Comiskey Park I (1-0) | 11-7 | Won 4 |
| » Starters: Lefty Grove vs Pat Caraway | First | -- |
| » Major-league debuts: Frank Grube (White Sox) |
| Wednesday, May 13 |
| » Defeated White Sox (9-13), 7-5 | Comiskey Park I (2-0) | 12-7 | Won 5 |
| » Starters: George Earnshaw vs Tommy Thomas | First | -- |
| Thursday, May 14 |
| » Defeated White Sox (9-14), 5-2 | Comiskey Park I (3-0) | 13-7 | Won 6 |
| » Starters: Rube Walberg vs Vic Frasier | First | -- |
| Friday, May 15 |
| » Defeated Indians (12-13), 4-0 | League Park II (1-0) | 14-7 | Won 7 |
| » Starters: Eddie Rommel vs Clint Brown | First | -- |
| Saturday, May 16 |
| » Defeated Indians (12-14), 12-5 | League Park II (2-0) | 15-7 | Won 8 |
| » Starters: Lefty Grove vs Willis Hudlin | First | -- |
| Sunday, May 17 |
| » Defeated Indians (12-15), 15-10 | League Park II (3-0) | 16-7 | Won 9 |
| » Starters: George Earnshaw vs Wes Ferrell | First | -- |
| Monday, May 18 |
| » Defeated Indians (12-16), 10-7 | League Park II (4-0) | 17-7 | Won 10 |
| » Starters: Rube Walberg vs Jake Miller | First | -- |
| Tuesday, May 19 |
| » Defeated Tigers (16-16), 5-0 | Tiger Stadium (1-0) | 18-7 | Won 11 |
| » Starters: George Earnshaw vs Waite Hoyt | First | -- |
| Wednesday, May 20 |
| » Defeated Tigers (16-17), 3-0 | Tiger Stadium (2-0) | 19-7 | Won 12 |
| » Starters: Lefty Grove vs George Uhle | First | -- |
| Thursday, May 21 |
| » Defeated Tigers (16-18), 12-5 | Tiger Stadium (3-0) | 20-7 | Won 13 |
| » Starters: Eddie Rommel vs Tommy Bridges | First | -- |
| Saturday, May 23 |
| » Defeated Red Sox (11-19), 7-1 | Shibe Park (7-2) | 21-7 | Won 14 |
| » Starters: Ed Durham vs George Earnshaw | First | -- |
| Sunday, May 24 |
| » Defeated Yankees (19-11), 7-3 | Yankee Stadium (2-2) | 22-7 | Won 15 |
| » Starters: Rube Walberg vs Red Ruffing | First | -- |
| Monday, May 25 |
| » Defeated Yankees (19-12), 4-2 | Shibe Park (8-2) | 23-7 | Won 16 |
| » Starters: Hank Johnson vs Lefty Grove | First | -- |
| » Defeated Yankees (19-13), 16-4 | Shibe Park (9-2) | 24-7 | Won 17 |
| » Starters: Roy Sherid vs Roy Mahaffey | First | -- |
| Tuesday, May 26 |
| » Lost to Yankees (20-13), 6-2 | Shibe Park (9-3) | 24-8 | |
| » Starters: Lefty Gomez vs Eddie Rommel | First | -- |
| Wednesday, May 27 |
| » Defeated Yankees (20-14), 6-5 | Shibe Park (10-3) | 25-8 | |
| » Starters: George Pipgras vs George Earnshaw | First | -- |
| Thursday, May 28 |
| » Defeated Yankees (20-15), 5-4 | Shibe Park (11-3) | 26-8 | Won 2 |
| » Starters: Red Ruffing vs Rube Walberg | First | -- |
| Saturday, May 30 |
| » Defeated Red Sox (12-24), 5-0 | Fenway Park (1-0) | 27-8 | Won 3 |
| » Starters: Lefty Grove vs Jack Russell | First | -- |
| » Lost to Red Sox (13-24), 6-5 | Fenway Park (1-1) | 27-9 | |
| » Starters: Roy Mahaffey vs Ed Durham | First | -- |
| Sunday, May 31 |
| » Defeated Red Sox (13-25), 7-4 | Braves Field (1-0) | 28-9 | |
| » Starters: George Earnshaw vs Milt Gaston | First | -- |
| » Lost to Red Sox (14-25), 7-3 | Braves Field (1-1) | 28-10 | |
| » Starters: Hank McDonald vs Ed Morris | First | -- |
| Tuesday, June 2 |
| » Defeated White Sox (17-22), 3-2 | Shibe Park (12-3) | 29-10 | |
| » Starters: Pat Caraway vs Rube Walberg | First | -- |
| Wednesday, June 3 |
| » Defeated White Sox (17-23), 2-1 | Shibe Park (13-3) | 30-10 | Won 2 |
| » Starters: Ted Lyons vs Lefty Grove | First | -- |
| Thursday, June 4 |
| » Defeated White Sox (17-24), 4-1 | Shibe Park (14-3) | 31-10 | Won 3 |
| » Starters: Tommy Thomas vs George Earnshaw | First | -- |
| Friday, June 5 |
| » Lost to White Sox (18-24), 7-5 | Shibe Park (14-4) | 31-11 | |
| » Starters: Red Faber vs Roy Mahaffey | First | -- |
| Saturday, June 6 |
| » Defeated Tigers (19-30), 11-5 | Shibe Park (15-4) | 32-11 | |
| » Starters: Waite Hoyt vs Rube Walberg | First | -- |
| Sunday, June 7 |
| » Defeated Tigers (19-31), 12-2 | Tiger Stadium (4-0) | 33-11 | Won 2 |
| » Starters: Roy Mahaffey vs Vic Sorrell | First | -- |
| Monday, June 8 |
| » Defeated Tigers (19-32), 7-3 | Shibe Park (16-4) | 34-11 | Won 3 |
| » Starters: Earl Whitehill vs Lefty Grove | First | -- |
| Tuesday, June 9 |
| » Defeated Tigers (19-33), 12-3 | Shibe Park (17-4) | 35-11 | Won 4 |
| » Starters: Tommy Bridges vs George Earnshaw | First | -- |
| Thursday, June 11 |
| » Lost to Browns (17-26), 8-2 | Shibe Park (17-5) | 35-12 | |
| » Starters: Wally Hebert vs Rube Walberg | First | -- |
| » Major-league debuts: Lew Krausse (Athletics) |
| Friday, June 12 |
| » Defeated Browns (17-27), 6-2 | Shibe Park (18-5) | 36-12 | |
| » Starters: Dick Coffman vs Roy Mahaffey | First | -- |
| Saturday, June 13 |
| » Defeated Browns (17-28), 10-3 | Shibe Park (19-5) | 37-12 | Won 2 |
| » Starters: Lefty Stewart vs Lefty Grove | First | -- |
| » Defeated Browns (17-29), 14-1 | Shibe Park (20-5) | 38-12 | Won 3 |
| » Starters: Dolly Gray vs George Earnshaw | First | -- |
| Sunday, June 14 |
| » Lost to Indians (26-26), 6-4 | League Park II (4-1) | 38-13 | |
| » Starters: Hank McDonald vs Clint Brown | First | -- |
| Monday, June 15 |
| » Defeated Indians (26-27), 4-1 | Shibe Park (21-5) | 39-13 | |
| » Starters: Willis Hudlin vs Rube Walberg | First | -- |
| Wednesday, June 17 |
| » Defeated Indians (26-28), 4-2 | Shibe Park (22-5) | 40-13 | Won 2 |
| » Starters: Wes Ferrell vs George Earnshaw | First | -- |
| Friday, June 19 |
| » Defeated White Sox (19-32), 10-4 | Comiskey Park I (4-0) | 41-13 | Won 3 |
| » Starters: Lefty Grove vs Pat Caraway | First | -- |
| Saturday, June 20 |
| » Defeated White Sox (19-33), 5-4 | Comiskey Park I (5-0) | 42-13 | Won 4 |
| » Starters: Rube Walberg vs Hal McKain | First | -- |
| Sunday, June 21 |
| » Defeated White Sox (19-34), 6-5 | Comiskey Park I (6-0) | 43-13 | Won 5 |
| » Starters: George Earnshaw vs Tommy Thomas | First | -- |
| Monday, June 22 |
| » Lost to White Sox (20-34), 8-2 | Comiskey Park I (6-1) | 43-14 | |
| » Starters: Bill Shores vs Vic Frasier | First | -- |
| Tuesday, June 23 |
| » Defeated Browns (20-36), 3-0 | Sportsman's Park III (2-0) | 44-14 | |
| » Starters: Lefty Grove vs Rip Collins | First | -- |
| » Lost to Browns (21-36), 5-4 | Sportsman's Park III (2-1) | 44-15 | |
| » Starters: Roy Mahaffey vs George Blaeholder | First | -- |
| Wednesday, June 24 |
| » Lost to Browns (22-36), 6-5 | Sportsman's Park III (2-2) | 44-16 | Lost 2 |
| » Starters: Rube Walberg vs Wally Hebert | First | -- |
| Thursday, June 25 |
| » Lost to Browns (23-36), 6-5 | Sportsman's Park III (2-3) | 44-17 | Lost 3 |
| » Starters: George Earnshaw vs Dolly Gray | First | -- |
| » Lost to Browns (24-36), 8-5 | Sportsman's Park III (2-4) | 44-18 | Lost 4 |
| » Starters: Bill Shores vs Lefty Stewart | First | -- |
| Saturday, June 27 |
| » Defeated Tigers (24-41), 9-5 | Tiger Stadium (5-0) | 45-18 | |
| » Starters: Lefty Grove vs Art Herring | First | -- |
| Sunday, June 28 |
| » Defeated Tigers (24-42), 9-1 | Tiger Stadium (6-0) | 46-18 | Won 2 |
| » Starters: Roy Mahaffey vs Tommy Bridges | First | -- |
| » Defeated Tigers (24-43), 5-1 | Tiger Stadium (7-0) | 47-18 | Won 3 |
| » Starters: Rube Walberg vs George Uhle | First | -- |
| Monday, June 29 |
| » Lost to Tigers (25-43), 6-5 | Tiger Stadium (7-1) | 47-19 | |
| » Starters: Eddie Rommel vs Earl Whitehill | First | -- |
| Tuesday, June 30 |
| » Defeated Indians (34-34), 11-7 | League Park II (5-1) | 48-19 | |
| » Starters: George Earnshaw vs Clint Brown | First | -- |
| Wednesday, July 1 |
| » Defeated Indians (34-35), 4-3 | League Park II (6-1) | 49-19 | Won 2 |
| » Starters: Lefty Grove vs Wes Ferrell | First | -- |
| Thursday, July 2 |
| » Lost to Indians (35-35), 12-4 | League Park II (6-2) | 49-20 | |
| » Starters: Rube Walberg vs Willis Hudlin | First | -- |
| Saturday, July 4 |
| » Defeated Red Sox (27-40), 9-7 | Shibe Park (23-5) | 50-20 | |
| » Starters: Ed Morris vs Roy Mahaffey | First | -- |
| » Defeated Red Sox (27-41), 6-2 | Shibe Park (24-5) | 51-20 | Won 2 |
| » Starters: Wilcy Moore vs Waite Hoyt | First | -- |
| Sunday, July 5 |
| » Lost to Senators (48-27), 4-2 | Griffith Stadium (2-4) | 51-21 | |
| » Starters: George Earnshaw vs Firpo Marberry | First | -- |
| Monday, July 6 |
| » Tied Senators, 0-0 | Griffith Stadium (2-4) | 51-21 | |
| » Starters: Rube Walberg vs Bump Hadley | First | -- |
| Tuesday, July 7 |
| » Defeated Senators (48-28), 7-3 | Griffith Stadium (3-4) | 52-21 | |
| » Starters: George Earnshaw vs Alvin Crowder | First | -- |
| Wednesday, July 8 |
| » Defeated Senators (48-29), 6-3 | Griffith Stadium (4-4) | 53-21 | Won 2 |
| » Starters: Lefty Grove vs Lloyd Brown | First | -- |
| Thursday, July 9 |
| » Lost to Yankees (42-31), 9-4 | Yankee Stadium (2-3) | 53-22 | |
| » Starters: Roy Mahaffey vs Lefty Gomez | First | -- |
| Friday, July 10 |
| » Defeated Yankees (42-32), 8-6 | Yankee Stadium (3-3) | 54-22 | |
| » Starters: Rube Walberg vs Hank Johnson | First | -- |
| Saturday, July 11 |
| » Lost to Yankees (43-32), 3-1 | Yankee Stadium (3-4) | 54-23 | |
| » Starters: Hank McDonald vs Red Ruffing | First | -- |
| Sunday, July 12 |
| » Defeated Red Sox (28-47), 7-2 | Braves Field (2-1) | 55-23 | |
| » Starters: Waite Hoyt vs Wilcy Moore | First | -- |
| » Defeated Red Sox (28-48), 6-2 | Braves Field (3-1) | 56-23 | Won 2 |
| » Starters: Roy Mahaffey vs Ed Morris | First | -- |
| Monday, July 13 |
| » Defeated Senators (51-31), 12-7 | Shibe Park (25-5) | 57-23 | Won 3 |
| » Starters: Firpo Marberry vs Lefty Grove | First | -- |
| » Lost to Senators (52-31), 6-4 | Shibe Park (25-6) | 57-24 | |
| » Starters: Alvin Crowder vs Rube Walberg | First | -- |
| Tuesday, July 14 |
| » Lost to Tigers (32-49), 12-3 | Shibe Park (25-7) | 57-25 | Lost 2 |
| » Starters: Art Herring vs George Earnshaw | First | -- |
| Wednesday, July 15 |
| » Defeated Tigers (32-50), 5-3 | Shibe Park (26-7) | 58-25 | |
| » Starters: Tommy Bridges vs Waite Hoyt | First | -- |
| » Defeated Tigers (32-51), 11-0 | Shibe Park (27-7) | 59-25 | Won 2 |
| » Starters: Earl Whitehill vs Hank McDonald | First | -- |
| Thursday, July 16 |
| » Defeated Tigers (32-52), 5-3 | Shibe Park (28-7) | 60-25 | Won 3 |
| » Starters: Vic Sorrell vs Roy Mahaffey | First | -- |
| Friday, July 17 |
| » Defeated Tigers (32-53), 6-3 | Shibe Park (29-7) | 61-25 | Won 4 |
| » Starters: George Uhle vs Lefty Grove | First | -- |
| Saturday, July 18 |
| » Defeated White Sox (30-52), 7-6 | Shibe Park (30-7) | 62-25 | Won 5 |
| » Starters: Red Faber vs George Earnshaw | First | -- |
| » Defeated White Sox (30-53), 7-2 | Shibe Park (31-7) | 63-25 | Won 6 |
| » Starters: Pat Caraway vs Rube Walberg | First | -- |
| Monday, July 20 |
| » Defeated White Sox (30-54), 12-7 | Shibe Park (32-7) | 64-25 | Won 7 |
| » Starters: Tommy Thomas vs Hank McDonald | First | -- |
| Tuesday, July 21 |
| » Defeated White Sox (30-55), 10-5 | Shibe Park (33-7) | 65-25 | Won 8 |
| » Starters: Vic Frasier vs Waite Hoyt | First | -- |
| Wednesday, July 22 |
| » Defeated Indians (44-45), 7-3 | Shibe Park (34-7) | 66-25 | Won 9 |
| » Starters: Mel Harder vs Rube Walberg | First | -- |
| Thursday, July 23 |
| » Defeated Indians (44-46), 5-2 | Shibe Park (35-7) | 67-25 | Won 10 |
| » Starters: Willis Hudlin vs George Earnshaw | First | -- |
| Friday, July 24 |
| » Defeated Indians (44-47), 2-1 | Shibe Park (36-7) | 68-25 | Won 11 |
| » Starters: Clint Brown vs Roy Mahaffey | First | -- |
| Saturday, July 25 |
| » Defeated Indians (44-48), 6-3 | Shibe Park (37-7) | 69-25 | Won 12 |
| » Starters: Wes Ferrell vs Lefty Grove | First | -- |
| » Defeated Indians (44-49), 3-2 | Shibe Park (38-7) | 70-25 | Won 13 |
| » Starters: Sarge Connally vs Hank McDonald | First | -- |
| Sunday, July 26 |
| » Lost to Indians (45-49), 13-2 | League Park II (6-3) | 70-26 | |
| » Starters: Waite Hoyt vs Mel Harder | First | -- |
| Monday, July 27 |
| » Defeated Browns (42-50), 5-4 | Shibe Park (39-7) | 71-26 | |
| » Starters: George Blaeholder vs Rube Walberg | First | -- |
| Tuesday, July 28 |
| » Defeated Browns (42-51), 6-3 | Shibe Park (40-7) | 72-26 | Won 2 |
| » Starters: Wally Hebert vs George Earnshaw | First | -- |
| Wednesday, July 29 |
| » Defeated Browns (42-52), 4-2 | Shibe Park (41-7) | 73-26 | Won 3 |
| » Starters: Lefty Stewart vs Roy Mahaffey | First | -- |
| Thursday, July 30 |
| » Defeated Browns (42-53), 8-5 | Shibe Park (42-7) | 74-26 | Won 4 |
| » Starters: Dolly Gray vs Waite Hoyt | First | -- |
| Saturday, August 1 |
| » Lost to Senators (62-37), 2-1 | Griffith Stadium (4-5) | 74-27 | |
| » Starters: Rube Walberg vs Firpo Marberry | First | -- |
| Sunday, August 2 |
| » Lost to Senators (63-37), 10-6 | Griffith Stadium (4-6) | 74-28 | Lost 2 |
| » Starters: Hank McDonald vs Sam Jones | First | -- |
| Monday, August 3 |
| » Defeated Senators (63-38), 3-2 | Shibe Park (43-7) | 75-28 | |
| » Starters: Sam Jones vs Lefty Grove | First | -- |
| » Defeated Senators (63-39), 6-5 | Shibe Park (44-7) | 76-28 | Won 2 |
| » Starters: Carl Fischer vs George Earnshaw | First | -- |
| Thursday, August 6 |
| » Lost to Yankees (61-42), 5-3 | Yankee Stadium (3-5) | 76-29 | |
| » Starters: Rube Walberg vs Lefty Gomez | First | -- |
| Saturday, August 8 |
| » Lost to Yankees (62-42), 3-2 | Yankee Stadium (3-6) | 76-30 | Lost 2 |
| » Starters: George Earnshaw vs Red Ruffing | First | -- |
| Sunday, August 9 |
| » Defeated Yankees (62-43), 5-3 | Yankee Stadium (4-6) | 77-30 | |
| » Starters: Roy Mahaffey vs George Pipgras | First | -- |
| Tuesday, August 11 |
| » Defeated Tigers (41-68), 8-1 | Tiger Stadium (8-1) | 78-30 | Won 2 |
| » Starters: Lefty Grove vs Vic Sorrell | First | -- |
| Wednesday, August 12 |
| » Lost to Tigers (42-68), 7-6 | Tiger Stadium (8-2) | 78-31 | |
| » Starters: George Earnshaw vs Art Herring | First | -- |
| Thursday, August 13 |
| » Defeated Tigers (42-69), 5-2 | Tiger Stadium (9-2) | 79-31 | |
| » Starters: Rube Walberg vs Earl Whitehill | First | -- |
| Saturday, August 15 |
| » Defeated Indians (53-58), 4-3 | League Park II (7-3) | 80-31 | Won 2 |
| » Starters: Lefty Grove vs Wes Ferrell | First | -- |
| Sunday, August 16 |
| » Defeated Indians (53-59), 6-4 | League Park II (8-3) | 81-31 | Won 3 |
| » Starters: Roy Mahaffey vs Sarge Connally | First | -- |
| Wednesday, August 19 |
| » Defeated White Sox (46-69), 4-2 | Comiskey Park I (7-1) | 82-31 | Won 4 |
| » Starters: Lefty Grove vs Red Faber | First | -- |
| Thursday, August 20 |
| » Lost to White Sox (47-69), 11-6 | Comiskey Park I (7-2) | 82-32 | |
| » Starters: Waite Hoyt vs Tommy Thomas | First | -- |
| Friday, August 21 |
| » Defeated White Sox (47-70), 15-12 | Comiskey Park I (8-2) | 83-32 | |
| » Starters: Rube Walberg vs Bob Weiland | First | -- |
| Saturday, August 22 |
| » Defeated White Sox (47-71), 7-1 | Comiskey Park I (9-2) | 84-32 | Won 2 |
| » Starters: Rube Walberg vs Pat Caraway | First | -- |
| Sunday, August 23 |
| » Lost to Browns (50-68), 1-0 | Sportsman's Park III (2-5) | 84-33 | |
| » Starters: Lefty Grove vs Dick Coffman | First | -- |
| » Defeated Browns (50-69), 10-0 | Sportsman's Park III (3-5) | 85-33 | |
| » Starters: Waite Hoyt vs Lefty Stewart | First | -- |
| Monday, August 24 |
| » Defeated Browns (50-70), 5-1 | Sportsman's Park III (4-5) | 86-33 | Won 2 |
| » Starters: Roy Mahaffey vs Dolly Gray | First | -- |
| Tuesday, August 25 |
| » Defeated Browns (50-71), 4-1 | Sportsman's Park III (5-5) | 87-33 | Won 3 |
| » Starters: Eddie Rommel vs George Blaeholder | First | -- |
| Wednesday, August 26 |
| » Lost to Browns (51-71), 9-5 | Sportsman's Park III (5-6) | 87-34 | |
| » Starters: Rube Walberg vs Rip Collins | First | -- |
| Friday, August 28 |
| » Defeated Yankees (72-51), 5-4 | Shibe Park (45-7) | 88-34 | |
| » Starters: Red Ruffing vs Roy Mahaffey | First | -- |
| Saturday, August 29 |
| » Defeated Yankees (72-52), 7-4 | Shibe Park (46-7) | 89-34 | Won 2 |
| » Starters: Lefty Gomez vs Lefty Grove | First | -- |
| Sunday, August 30 |
| » Lost to Senators (74-51), 5-1 | Griffith Stadium (4-7) | 89-35 | |
| » Starters: Eddie Rommel vs Alvin Crowder | First | -- |
| Monday, August 31 |
| » Defeated Red Sox (49-75), 3-0 | Shibe Park (47-7) | 90-35 | |
| » Starters: Wilcy Moore vs Waite Hoyt | First | -- |
| Tuesday, September 1 |
| » Lost to Senators (76-51), 5-1 | Shibe Park (47-8) | 90-36 | |
| » Starters: Sam Jones vs Rube Walberg | First | -- |
| Wednesday, September 2 |
| » Lost to Senators (77-51), 5-2 | Shibe Park (47-9) | 90-37 | Lost 2 |
| » Starters: Alvin Crowder vs Roy Mahaffey | First | -- |
| Friday, September 4 |
| » Defeated Red Sox (49-79), 2-0 | Fenway Park (2-1) | 91-37 | |
| » Starters: Lefty Grove vs Ed Durham | First | -- |
| » Defeated Red Sox (49-80), 6-1 | Fenway Park (3-1) | 92-37 | Won 2 |
| » Starters: Waite Hoyt vs Jack Russell | First | -- |
| Saturday, September 5 |
| » Defeated Red Sox (49-81), 8-0 | Fenway Park (4-1) | 93-37 | Won 3 |
| » Starters: George Earnshaw vs Danny MacFayden | First | -- |
| » Lost to Red Sox (50-81), 6-3 | Fenway Park (4-2) | 93-38 | |
| » Starters: Rube Walberg vs Wilcy Moore | First | -- |
| Sunday, September 6 |
| » Defeated Red Sox (50-82), 5-3 | Braves Field (4-1) | 94-38 | |
| » Starters: Eddie Rommel vs Milt Gaston | First | -- |
| Monday, September 7 |
| » Lost to Yankees (79-55), 15-3 | Shibe Park (47-10) | 94-39 | |
| » Starters: Ivy Andrews vs Roy Mahaffey | First | -- |
| » Lost to Yankees (80-55), 9-4 | Shibe Park (47-11) | 94-40 | Lost 2 |
| » Starters: Gordon Rhodes vs Waite Hoyt | First | -- |
| Tuesday, September 8 |
| » Defeated Senators (81-54), 10-1 | Shibe Park (48-11) | 95-40 | |
| » Starters: Sam Jones vs Lefty Grove | First | -- |
| Wednesday, September 9 |
| » Lost to Senators (82-54), 2-1 | Shibe Park (48-12) | 95-41 | |
| » Starters: Alvin Crowder vs Rube Walberg | First | -- |
| Thursday, September 10 |
| » Defeated Browns (57-81), 6-3 | Shibe Park (49-12) | 96-41 | |
| » Starters: Wally Hebert vs George Earnshaw | First | -- |
| Saturday, September 12 |
| » Defeated Browns (57-82), 3-2 | Shibe Park (50-12) | 97-41 | Won 2 |
| » Starters: Dolly Gray vs Lefty Grove | First | -- |
| » Lost to Browns (58-82), 10-2 | Shibe Park (50-13) | 97-42 | |
| » Starters: Dick Coffman vs Waite Hoyt | First | -- |
| Monday, September 14 |
| » Lost to Indians (72-66), 6-2 | Shibe Park (50-14) | 97-43 | Lost 2 |
| » Starters: Willis Hudlin vs Rube Walberg | First | -- |
| » Defeated Indians (72-67), 9-7 | Shibe Park (51-14) | 98-43 | |
| » Starters: Clint Brown vs Waite Hoyt | First | -- |
| Tuesday, September 15 |
| » Defeated Indians (72-68), 14-3 | Shibe Park (52-14) | 99-43 | Won 2 |
| » Starters: Mel Harder vs Eddie Rommel | First | -- |
| Wednesday, September 16 |
| » Defeated Indians (72-69), 7-5 | Shibe Park (53-14) | 100-43 | Won 3 |
| » Starters: Wes Ferrell vs George Earnshaw | First | -- |
| Thursday, September 17 |
| » Major-league debuts: Babe Phelps (Senators) |
| Friday, September 18 |
| » Defeated White Sox (55-88), 3-1 | Shibe Park (54-14) | 101-43 | Won 4 |
| » Starters: Red Faber vs Lefty Grove | First | -- |
| Saturday, September 19 |
| » Defeated White Sox (55-89), 10-3 | Shibe Park (55-14) | 102-43 | Won 5 |
| » Starters: Bob Weiland vs Rube Walberg | First | -- |
| » Defeated White Sox (55-90), 3-1 | Shibe Park (56-14) | 103-43 | Won 6 |
| » Starters: Tommy Thomas vs Waite Hoyt | First | -- |
| Sunday, September 20 |
| » Major-league debuts: Monte Weaver (Senators) |
| Monday, September 21 |
| » Defeated Tigers (59-88), 3-2 | Shibe Park (57-14) | 104-43 | Won 7 |
| » Starters: Chief Hogsett vs Eddie Rommel | First | -- |
| » Lost to Tigers (60-88), 6-5 | Shibe Park (57-15) | 104-44 | |
| » Starters: Tommy Bridges vs Jim Peterson | First | -- |
| Tuesday, September 22 |
| » Defeated Tigers (60-89), 8-6 | Shibe Park (58-15) | 105-44 | |
| » Starters: Art Herring vs George Earnshaw | First | -- |
| Thursday, September 24 |
| » Defeated Red Sox (61-89), 9-4 | Shibe Park (59-15) | 106-44 | Won 2 |
| » Starters: Wilcy Moore vs Lefty Grove | First | -- |
| Friday, September 25 |
| » Defeated Red Sox (61-90), 7-1 | Shibe Park (60-15) | 107-44 | Won 3 |
| » Starters: Ed Durham vs Lew Krausse | First | -- |
| Sunday, September 27 |
| » Lost to Yankees (94-59), 13-1 | Yankee Stadium (4-7) | 107-45 | |
| » Starters: Lefty Grove vs Gordon Rhodes | First | -- |
| Monday, November 9 |
| Future Athletic Whitey Herzog is born in New Athens, IL. |
Game information provided by Retrosheet (www.retrosheet.org) |
