| Thursday, January 3 |
| Former Red Sox Charlie Smith dies in Wickliffe, OH at the age of 49. |
| Tuesday, February 5 |
| Future Red Sox Al Worthington is born in Birmingham, AL. |
| Saturday, February 23 |
| Future Red Sox Elston Howard is born in St. Louis, MO. |
| Wednesday, April 17 |
| » Major-league debuts: Ad Liska (Senators) |
| Thursday, April 18 |
| » Lost to Yankees (1-0), 7-3 | Yankee Stadium (0-1) | 0-1 | |
| » Starters: Red Ruffing vs George Pipgras | Sixth | 2 out |
| » Major-league debuts: Bill Narleski and Russ Scarritt (Red Sox) |
| Friday, April 19 |
| » Lost to Senators (1-2), 3-1 | Griffith Stadium (0-1) | 0-2 | Lost 2 |
| » Starters: Ed Morris vs Firpo Marberry | Sixth | 2 out |
| » Major-league debuts: Ed Durham (Red Sox) |
| Saturday, April 20 |
| » Defeated Senators (1-3), 6-5 | Griffith Stadium (1-1) | 1-2 | |
| » Starters: Jack Russell vs Sam Jones | Fifth | 1½ out |
| Future Red Sox Harry Agganis is born in Lynn, MA. |
| Tuesday, April 23 |
| » Defeated Yankees (2-2), 4-2 | Fenway Park (1-0) | 2-2 | Won 2 |
| » Starters: George Pipgras vs Ed Morris | Fourth | 1 out |
| Wednesday, April 24 |
| » Lost to Yankees (3-2), 9-3 | Fenway Park (1-1) | 2-3 | |
| » Starters: Waite Hoyt vs Red Ruffing | Sixth | 1½ out |
| Friday, April 26 |
| » Defeated Senators (2-5), 2-1 | Fenway Park (2-1) | 3-3 | |
| » Starters: Ad Liska vs Jack Russell | Fourth | 1½ out |
| Saturday, April 27 |
| » Lost to Senators (3-5), 3-2 | Fenway Park (2-2) | 3-4 | |
| » Starters: Sam Jones vs Danny MacFayden | Sixth | 2 out |
| Sunday, April 28 |
| » Lost to Athletics (6-3), 7-3 | Braves Field (0-1) | 3-5 | Lost 2 |
| » Starters: Eddie Rommel vs Red Ruffing | Seventh | 3 out |
| Monday, April 29 |
| » Major-league debuts: Gordon Rhodes (Yankees) |
| Future Red Sox Mickey McDermott is born in Poughkeepsie, NY. |
| Tuesday, April 30 |
| » Defeated Athletics (7-4), 4-1 | Fenway Park (3-2) | 4-5 | |
| » Starters: George Earnshaw vs Ed Morris | Fifth | 3½ out |
| Wednesday, May 1 |
| » Lost to Athletics (8-4), 24-6 | Fenway Park (3-3) | 4-6 | |
| » Starters: Lefty Grove vs Milt Gaston | Fifth | 4½ out |
| Thursday, May 2 |
| » Lost to Athletics (9-4), 5-1 | Fenway Park (3-4) | 4-7 | Lost 2 |
| » Starters: Lefty Grove vs Jack Russell | Sixth | 5 out |
| Saturday, May 4 |
| » Lost to Tigers (8-9), 2-1 | Tiger Stadium (0-1) | 4-8 | Lost 3 |
| » Starters: Red Ruffing vs Vic Sorrell | Seventh | 5½ out |
| Sunday, May 5 |
| » Lost to Tigers (9-9), 10-2 | Tiger Stadium (0-2) | 4-9 | Lost 4 |
| » Starters: Ed Morris vs Augie Prudhomme | Seventh | 5½ out |
| Monday, May 6 |
| » Lost to Tigers (10-9), 8-4 | Tiger Stadium (0-3) | 4-10 | Lost 5 |
| » Starters: Milt Gaston vs Ownie Carroll | Eighth | 6 out |
| Tuesday, May 7 |
| » Defeated Indians (7-11), 5-4 | League Park II (1-0) | 5-10 | |
| » Starters: Jack Russell vs Wes Ferrell | Seventh | 5½ out |
| Future Red Sox Dick Williams is born in St. Louis, MO. |
| Wednesday, May 8 |
| » Lost to Indians (8-11), 3-1 | League Park II (1-1) | 5-11 | |
| » Starters: Danny MacFayden vs Willis Hudlin | Seventh | 6½ out |
| Thursday, May 9 |
| » Lost to Indians (9-11), 4-3 | League Park II (1-2) | 5-12 | Lost 2 |
| » Starters: Milt Gaston vs Joe Shaute | Eighth | 7½ out |
| Friday, May 10 |
| » Lost to Browns (12-8), 4-3 | Sportsman's Park III (0-1) | 5-13 | Lost 3 |
| » Starters: Red Ruffing vs Jack Ogden | Eighth | 8½ out |
| Saturday, May 11 |
| » Defeated Browns (12-9), 8-2 | Sportsman's Park III (1-1) | 6-13 | |
| » Starters: Ed Morris vs Alvin Crowder | Eighth | 7½ out |
| Sunday, May 12 |
| » Lost to Browns (13-9), 15-3 | Sportsman's Park III (1-2) | 6-14 | |
| » Starters: Jack Russell vs Rip Collins | Seventh | 7½ out |
| Monday, May 13 |
| » Defeated White Sox (8-15), 2-1 | Comiskey Park I (1-0) | 7-14 | |
| » Starters: Danny MacFayden vs Grady Adkins | Seventh | 6½ out |
| Tuesday, May 14 |
| » Lost to White Sox (9-15), 6-2 | Comiskey Park I (1-1) | 7-15 | |
| » Starters: Jack Russell vs Bob Weiland | Eighth | 7½ out |
| Wednesday, May 15 |
| » Lost to White Sox (10-15), 8-4 | Comiskey Park I (1-2) | 7-16 | Lost 2 |
| » Starters: Red Ruffing vs Ted Lyons | Eighth | 7½ out |
| Friday, May 17 |
| » Defeated Yankees (13-9), 5-3 | Yankee Stadium (1-1) | 8-16 | |
| » Starters: Ed Morris vs Waite Hoyt | Eighth | 7½ out |
| Saturday, May 18 |
| » Lost to Yankees (14-9), 5-2 | Yankee Stadium (1-2) | 8-17 | |
| » Starters: Danny MacFayden vs Herb Pennock | Eighth | 9½ out |
| » Lost to Yankees (15-9), 5-0 | Yankee Stadium (1-3) | 8-18 | Lost 2 |
| » Starters: Milt Gaston vs George Pipgras | Eighth | 9½ out |
| Sunday, May 19 |
| » Lost to Yankees (16-9), 3-0 | Yankee Stadium (1-4) | 8-19 | Lost 3 |
| » Starters: Jack Russell vs Fred Heimach | Eighth | 10½ out |
| Monday, May 20 |
| » Lost to Athletics (19-8), 5-1 | Shibe Park (0-1) | 8-20 | Lost 4 |
| » Starters: Red Ruffing vs Eddie Rommel | Eighth | 11½ out |
| Wednesday, May 22 |
| » Lost to Athletics (20-8), 16-2 | Shibe Park (0-2) | 8-21 | Lost 5 |
| » Starters: Ed Morris vs Lefty Grove | Eighth | 12½ out |
| Thursday, May 23 |
| » Lost to Yankees (17-11), 7-6 | Fenway Park (3-5) | 8-22 | Lost 6 |
| » Starters: George Pipgras vs Milt Gaston | Eighth | 14 out |
| Friday, May 24 |
| » Defeated Yankees (17-12), 5-0 | Fenway Park (4-5) | 9-22 | |
| » Starters: Herb Pennock vs Danny MacFayden | Eighth | 14 out |
| Saturday, May 25 |
| » Defeated Yankees (17-13), 10-8 | Fenway Park (5-5) | 10-22 | Won 2 |
| » Starters: Fred Heimach vs Jack Russell | Eighth | 14½ out |
| » Lost to Yankees (18-13), 8-3 | Fenway Park (5-6) | 10-23 | |
| » Starters: Tom Zachary vs Red Ruffing | Eighth | 14½ out |
| Sunday, May 26 |
| » Lost to Yankees (19-13), 15-4 | Braves Field (0-2) | 10-24 | Lost 2 |
| » Starters: Waite Hoyt vs Ed Morris | Eighth | 15½ out |
| Tuesday, May 28 |
| » Defeated Athletics (25-9), 5-4 | Fenway Park (6-6) | 11-24 | |
| » Starters: Rube Walberg vs Milt Gaston | Seventh | 14½ out |
| Wednesday, May 29 |
| » Lost to Athletics (26-9), 7-1 | Fenway Park (6-7) | 11-25 | |
| » Starters: George Earnshaw vs Danny MacFayden | Eighth | 15½ out |
| Thursday, May 30 |
| » Lost to Athletics (27-9), 9-2 | Fenway Park (6-8) | 11-26 | Lost 2 |
| » Starters: Lefty Grove vs Jack Russell | Eighth | 17½ out |
| » Lost to Athletics (28-9), 9-3 | Fenway Park (6-9) | 11-27 | Lost 3 |
| » Starters: Jack Quinn vs Red Ruffing | Eighth | 17½ out |
| Saturday, June 1 |
| » Lost to Indians (20-20), 3-2 | Fenway Park (6-10) | 11-28 | Lost 4 |
| » Starters: Jake Miller vs Ed Morris | Eighth | 19 out |
| Sunday, June 2 |
| » Defeated Indians (20-21), 12-3 | Braves Field (1-2) | 12-28 | |
| » Starters: Joe Shaute vs Milt Gaston | Eighth | 18½ out |
| Tuesday, June 4 |
| » Lost to Indians (21-21), 4-0 | Fenway Park (6-11) | 12-29 | |
| » Starters: Jimmy Zinn vs Red Ruffing | Eighth | 19 out |
| Wednesday, June 5 |
| » Defeated White Sox (16-31), 17-2 | Fenway Park (7-11) | 13-29 | |
| » Starters: Tommy Thomas vs Danny MacFayden | Eighth | 19 out |
| Thursday, June 6 |
| » Lost to White Sox (17-31), 9-5 | Fenway Park (7-12) | 13-30 | |
| » Starters: Grady Adkins vs Ed Morris | Eighth | 20 out |
| Saturday, June 8 |
| » Lost to White Sox (18-31), 7-2 | Fenway Park (7-13) | 13-31 | Lost 2 |
| » Starters: Ted Lyons vs Jack Russell | Eighth | 19½ out |
| » Defeated White Sox (18-32), 4-1 | Fenway Park (8-13) | 14-31 | |
| » Starters: Red Faber vs Milt Gaston | Eighth | 19½ out |
| Sunday, June 9 |
| » Defeated Tigers (27-25), 7-6 | Braves Field (2-2) | 15-31 | Won 2 |
| » Starters: George Uhle vs Ed Morris | Eighth | 19 out |
| Monday, June 10 |
| » Lost to Tigers (28-25), 1-0 | Fenway Park (8-14) | 15-32 | |
| » Starters: Vic Sorrell vs Red Ruffing | Eighth | 20 out |
| Tuesday, June 11 |
| » Lost to Tigers (29-25), 5-3 | Fenway Park (8-15) | 15-33 | Lost 2 |
| » Starters: Ownie Carroll vs Danny MacFayden | Eighth | 21 out |
| Thursday, June 13 |
| » Defeated Browns (29-23), 4-1 | Fenway Park (9-15) | 16-33 | |
| » Starters: Rip Collins vs Milt Gaston | Eighth | 21½ out |
| Friday, June 14 |
| » Lost to Browns (30-23), 7-6 | Fenway Park (9-16) | 16-34 | |
| » Starters: Alvin Crowder vs Ed Morris | Eighth | 22½ out |
| Saturday, June 15 |
| » Lost to Browns (31-23), 12-8 | Fenway Park (9-17) | 16-35 | Lost 2 |
| » Starters: Dolly Gray vs Jack Russell | Eighth | 23½ out |
| Sunday, June 16 |
| » Lost to Browns (32-23), 5-2 | Braves Field (2-3) | 16-36 | Lost 3 |
| » Starters: Chad Kimsey vs Danny MacFayden | Eighth | 23½ out |
| Monday, June 17 |
| » Defeated Tigers (30-29), 6-5 | Fenway Park (10-17) | 17-36 | |
| » Starters: Ownie Carroll vs Red Ruffing | Eighth | 23 out |
| » Lost to Tigers (31-29), 8-3 | Fenway Park (10-18) | 17-37 | |
| » Starters: George Uhle vs Milt Gaston | Eighth | 23 out |
| Tuesday, June 18 |
| » Lost to Yankees (32-20), 9-0 | Yankee Stadium (1-5) | 17-38 | Lost 2 |
| » Starters: Ed Morris vs Fred Heimach | Eighth | 23½ out |
| » Defeated Yankees (32-21), 7-4 | Yankee Stadium (2-5) | 18-38 | |
| » Starters: Bill Bayne vs George Pipgras | Eighth | 23½ out |
| Wednesday, June 19 |
| » Lost to Yankees (33-21), 13-2 | Yankee Stadium (2-6) | 18-39 | |
| » Starters: Jack Russell vs Ed Wells | Eighth | 24 out |
| Thursday, June 20 |
| » Defeated Senators (20-33), 6-4 | Griffith Stadium (2-1) | 19-39 | |
| » Starters: Danny MacFayden vs Ad Liska | Eighth | 23½ out |
| Friday, June 21 |
| » Lost to Senators (21-33), 5-4 | Griffith Stadium (2-2) | 19-40 | |
| » Starters: Red Ruffing vs Firpo Marberry | Eighth | 24 out |
| Saturday, June 22 |
| » Lost to Senators (22-33), 3-2 | Griffith Stadium (2-3) | 19-41 | Lost 2 |
| » Starters: Milt Gaston vs Lloyd Brown | Eighth | 25 out |
| » Lost to Senators (23-33), 5-1 | Griffith Stadium (2-4) | 19-42 | Lost 3 |
| » Starters: Ed Morris vs Bobby Burke | Eighth | 25 out |
| Sunday, June 23 |
| » Lost to Senators (24-33), 7-1 | Griffith Stadium (2-5) | 19-43 | Lost 4 |
| » Starters: Bill Bayne vs Myles Thomas | Seventh | 26 out |
| Monday, June 24 |
| » Lost to Athletics (44-15), 5-4 | Shibe Park (0-3) | 19-44 | Lost 5 |
| » Starters: Jack Russell vs Eddie Rommel | Eighth | 27 out |
| Tuesday, June 25 |
| » Lost to Athletics (45-15), 7-1 | Shibe Park (0-4) | 19-45 | Lost 6 |
| » Starters: Danny MacFayden vs Lefty Grove | Eighth | 29 out |
| » Lost to Athletics (46-15), 8-2 | Shibe Park (0-5) | 19-46 | Lost 7 |
| » Starters: Red Ruffing vs Bill Shores | Eighth | 29 out |
| Wednesday, June 26 |
| » Lost to Athletics (47-15), 6-5 | Shibe Park (0-6) | 19-47 | Lost 8 |
| » Starters: Milt Gaston vs George Earnshaw | Eighth | 30 out |
| Thursday, June 27 |
| » Defeated Senators (25-35), 4-1 | Fenway Park (11-18) | 20-47 | |
| » Starters: Ad Liska vs Ed Morris | Eighth | 30 out |
| Friday, June 28 |
| » Defeated Senators (25-36), 5-2 | Fenway Park (12-18) | 21-47 | Won 2 |
| » Starters: Myles Thomas vs Jack Russell | Eighth | 29½ out |
| Saturday, June 29 |
| » Defeated Senators (25-37), 5-2 | Fenway Park (13-18) | 22-47 | Won 3 |
| » Starters: Bobby Burke vs Red Ruffing | Eighth | 28½ out |
| Sunday, June 30 |
| » Lost to Yankees (38-26), 6-4 | Braves Field (2-4) | 22-48 | |
| » Starters: Ed Wells vs Danny MacFayden | Eighth | 28½ out |
| Monday, July 1 |
| » Lost to Yankees (39-26), 3-2 | Yankee Stadium (2-7) | 22-49 | Lost 2 |
| » Starters: Bill Bayne vs Herb Pennock | Eighth | 29 out |
| Tuesday, July 2 |
| » Lost to Yankees (40-26), 4-3 | Yankee Stadium (2-8) | 22-50 | Lost 3 |
| » Starters: Ed Morris vs Waite Hoyt | Eighth | 30½ out |
| Future Red Sox Chuck Stobbs is born in Wheeling, WV. |
| Wednesday, July 3 |
| » Lost to Yankees (41-26), 6-5 | Yankee Stadium (2-9) | 22-51 | Lost 4 |
| » Starters: Red Ruffing vs Tom Zachary | Eighth | 31½ out |
| Thursday, July 4 |
| » Lost to Athletics (52-17), 3-1 | Shibe Park (0-7) | 22-52 | Lost 5 |
| » Starters: Milt Gaston vs Lefty Grove | Eighth | 33½ out |
| » Lost to Athletics (53-17), 8-1 | Shibe Park (0-8) | 22-53 | Lost 6 |
| » Starters: Jack Russell vs Jack Quinn | Eighth | 33½ out |
| Sunday, July 7 |
| » Lost to Indians (36-36), 4-2 | League Park II (1-3) | 22-54 | Lost 7 |
| » Starters: Red Ruffing vs Willis Hudlin | Eighth | 32½ out |
| » Defeated Indians (36-37), 3-0 | League Park II (2-3) | 23-54 | |
| » Starters: Ed Morris vs Wes Ferrell | Eighth | 32½ out |
| Monday, July 8 |
| » Lost to Indians (37-37), 5-2 | League Park II (2-4) | 23-55 | |
| » Starters: Danny MacFayden vs Joe Shaute | Eighth | 33½ out |
| Wednesday, July 10 |
| » Lost to Tigers (42-38), 10-6 | Tiger Stadium (0-4) | 23-56 | Lost 2 |
| » Starters: Milt Gaston vs Vic Sorrell | Eighth | 33½ out |
| Thursday, July 11 |
| » Defeated Tigers (42-39), 15-8 | Tiger Stadium (1-4) | 24-56 | |
| » Starters: Jack Russell vs Augie Prudhomme | Eighth | 33 out |
| Friday, July 12 |
| » Lost to Tigers (43-39), 13-12 | Tiger Stadium (1-5) | 24-57 | |
| » Starters: Red Ruffing vs Earl Whitehill | Eighth | 34½ out |
| Sunday, July 14 |
| » Defeated Browns (47-35), 5-2 | Sportsman's Park III (2-2) | 25-57 | |
| » Starters: Jack Russell vs George Blaeholder | Eighth | 34½ out |
| Monday, July 15 |
| » Lost to Browns (48-35), 10-3 | Sportsman's Park III (2-3) | 25-58 | |
| » Starters: Danny MacFayden vs Lefty Stewart | Eighth | 35 out |
| Tuesday, July 16 |
| » Defeated Browns (48-36), 11-2 | Sportsman's Park III (3-3) | 26-58 | |
| » Starters: Milt Gaston vs Rip Collins | Eighth | 35 out |
| Wednesday, July 17 |
| » Lost to Browns (49-36), 4-0 | Sportsman's Park III (3-4) | 26-59 | |
| » Starters: Red Ruffing vs Dolly Gray | Eighth | 35 out |
| Thursday, July 18 |
| » Lost to White Sox (32-56), 2-1 | Comiskey Park I (1-3) | 26-60 | Lost 2 |
| » Starters: Danny MacFayden vs Red Faber | Eighth | 36 out |
| Friday, July 19 |
| » Lost to White Sox (33-56), 2-1 | Comiskey Park I (1-4) | 26-61 | Lost 3 |
| » Starters: Jack Russell vs Tommy Thomas | Eighth | 37 out |
| Saturday, July 20 |
| » Lost to White Sox (34-56), 4-3 | Comiskey Park I (1-5) | 26-62 | Lost 4 |
| » Starters: Milt Gaston vs Ed Walsh | Eighth | 38 out |
| Sunday, July 21 |
| » Lost to White Sox (35-56), 10-0 | Comiskey Park I (1-6) | 26-63 | Lost 5 |
| » Starters: Red Ruffing vs Ted Lyons | Eighth | 39 out |
| Tuesday, July 23 |
| » Lost to Browns (52-39), 11-4 | Fenway Park (13-19) | 26-64 | Lost 6 |
| » Starters: Alvin Crowder vs Danny MacFayden | Eighth | 39½ out |
| Wednesday, July 24 |
| » Defeated Browns (52-40), 9-7 | Fenway Park (14-19) | 27-64 | |
| » Starters: Jack Ogden vs Jack Russell | Eighth | 39½ out |
| Friday, July 26 |
| » Lost to Tigers (46-47), 4-1 | Fenway Park (14-20) | 27-65 | |
| » Starters: Ownie Carroll vs Milt Gaston | Eighth | 41 out |
| Saturday, July 27 |
| » Defeated Tigers (46-48), 4-0 | Fenway Park (15-20) | 28-65 | |
| » Starters: Vic Sorrell vs Red Ruffing | Eighth | 41 out |
| Sunday, July 28 |
| » Lost to Tigers (47-48), 5-3 | Braves Field (2-5) | 28-66 | |
| » Starters: Skinny Graham vs Jack Russell | Eighth | 41½ out |
| Tuesday, July 30 |
| » Lost to Indians (50-46), 11-4 | Fenway Park (15-21) | 28-67 | Lost 2 |
| » Starters: Wes Ferrell vs Ed Morris | Eighth | 42 out |
| Wednesday, July 31 |
| » Defeated Indians (50-47), 4-0 | Fenway Park (16-21) | 29-67 | |
| » Starters: Jake Miller vs Danny MacFayden | Eighth | 42½ out |
| » Lost to Indians (51-47), 6-2 | Fenway Park (16-22) | 29-68 | |
| » Starters: Willis Hudlin vs Milt Gaston | Eighth | 42½ out |
| Thursday, August 1 |
| » Lost to Indians (52-47), 10-3 | Fenway Park (16-23) | 29-69 | Lost 2 |
| » Starters: Jimmy Zinn vs Red Ruffing | Eighth | 43½ out |
| Friday, August 2 |
| » Defeated White Sox (39-62), 3-2 | Fenway Park (17-23) | 30-69 | |
| » Starters: Red Faber vs Jack Russell | Eighth | 43½ out |
| Saturday, August 3 |
| » Lost to White Sox (40-62), 15-4 | Fenway Park (17-24) | 30-70 | |
| » Starters: Tommy Thomas vs Red Ruffing | Eighth | 44 out |
| Sunday, August 4 |
| » Defeated White Sox (40-63), 8-0 | Braves Field (3-5) | 31-70 | |
| » Starters: Ed Walsh vs Ed Morris | Eighth | 43½ out |
| Wednesday, August 7 |
| » Lost to Senators (41-60), 4-2 | Fenway Park (17-25) | 31-71 | |
| » Starters: Myles Thomas vs Danny MacFayden | Eighth | 44 out |
| Thursday, August 8 |
| » Lost to Senators (42-60), 3-2 | Fenway Park (17-26) | 31-72 | Lost 2 |
| » Starters: Lloyd Brown vs Milt Gaston | Seventh | 44 out |
| Saturday, August 10 |
| » Defeated White Sox (42-65), 10-7 | Comiskey Park I (2-6) | 32-72 | |
| » Starters: Jack Russell vs Ed Walsh | Eighth | 44 out |
| Sunday, August 11 |
| » Lost to White Sox (43-65), 6-3 | Comiskey Park I (2-7) | 32-73 | |
| » Starters: Red Ruffing vs Tommy Thomas | Eighth | 44 out |
| Monday, August 12 |
| » Defeated White Sox (43-66), 3-0 | Comiskey Park I (3-7) | 33-73 | |
| » Starters: Danny MacFayden vs Ted Lyons | Eighth | 44 out |
| Tuesday, August 13 |
| » Defeated White Sox (43-67), 8-2 | Comiskey Park I (4-7) | 34-73 | Won 2 |
| » Starters: Ed Morris vs Bob Weiland | Eighth | 44 out |
| Wednesday, August 14 |
| » Defeated Browns (57-54), 4-1 | Sportsman's Park III (4-4) | 35-73 | Won 3 |
| » Starters: Milt Gaston vs Dolly Gray | Eighth | 44 out |
| Thursday, August 15 |
| » Lost to Browns (58-54), 3-0 | Sportsman's Park III (4-5) | 35-74 | |
| » Starters: Jack Russell vs George Blaeholder | Eighth | 44½ out |
| Friday, August 16 |
| » Defeated Browns (58-55), 3-2 | Sportsman's Park III (5-5) | 36-74 | |
| » Starters: Red Ruffing vs Alvin Crowder | Eighth | 44½ out |
| Saturday, August 17 |
| » Defeated Browns (58-56), 1-0 | Sportsman's Park III (6-5) | 37-74 | Won 2 |
| » Starters: Danny MacFayden vs Lefty Stewart | Eighth | 43½ out |
| Sunday, August 18 |
| » Defeated Tigers (54-60), 5-4 | Tiger Stadium (2-5) | 38-74 | Won 3 |
| » Starters: Ed Morris vs Ownie Carroll | Eighth | 42½ out |
| Monday, August 19 |
| » Defeated Tigers (54-61), 3-2 | Tiger Stadium (3-5) | 39-74 | Won 4 |
| » Starters: Milt Gaston vs Earl Whitehill | Eighth | 43 out |
| » Lost to Tigers (55-61), 6-2 | Tiger Stadium (3-6) | 39-75 | |
| » Starters: Jack Russell vs Vic Sorrell | Eighth | 43 out |
| Tuesday, August 20 |
| » Defeated Tigers (55-62), 12-8 | Tiger Stadium (4-6) | 40-75 | |
| » Starters: Red Ruffing vs Skinny Graham | Eighth | 42 out |
| Wednesday, August 21 |
| » Lost to Tigers (56-62), 13-2 | Tiger Stadium (4-7) | 40-76 | |
| » Starters: Bill Bayne vs George Uhle | Eighth | 42 out |
| Friday, August 23 |
| » Defeated Indians (61-56), 8-5 | League Park II (3-4) | 41-76 | |
| » Starters: Danny MacFayden vs Willis Hudlin | Eighth | 40½ out |
| Saturday, August 24 |
| » Defeated Indians (61-57), 5-2 | League Park II (4-4) | 42-76 | Won 2 |
| » Starters: Ed Morris vs Jake Miller | Eighth | 41 out |
| » Lost to Indians (62-57), 6-2 | League Park II (4-5) | 42-77 | |
| » Starters: Milt Gaston vs Ken Holloway | Eighth | 41 out |
| Sunday, August 25 |
| » Lost to Indians (63-57), 5-4 | League Park II (4-6) | 42-78 | Lost 2 |
| » Starters: Jack Russell vs Wes Ferrell | Eighth | 40½ out |
| » Defeated Indians (63-58), 5-3 | League Park II (5-6) | 43-78 | |
| » Starters: Red Ruffing vs Jimmy Zinn | Eighth | 40½ out |
| Tuesday, August 27 |
| » Lost to Senators (54-65), 5-4 | Griffith Stadium (2-6) | 43-79 | |
| » Starters: Danny MacFayden vs Sam Jones | Eighth | 40½ out |
| Wednesday, August 28 |
| » Lost to Senators (55-65), 7-4 | Griffith Stadium (2-7) | 43-80 | Lost 2 |
| » Starters: Milt Gaston vs Myles Thomas | Eighth | 41½ out |
| Thursday, August 29 |
| » Lost to Athletics (86-39), 7-6 | Shibe Park (0-9) | 43-81 | Lost 3 |
| » Starters: Ed Morris vs Bill Shores | Eighth | 42½ out |
| Friday, August 30 |
| » Defeated Athletics (86-40), 4-2 | Shibe Park (1-9) | 44-81 | |
| » Starters: Jack Russell vs George Earnshaw | Eighth | 41½ out |
| Saturday, August 31 |
| » Lost to Athletics (87-40), 9-4 | Shibe Park (1-10) | 44-82 | |
| » Starters: Red Ruffing vs Lefty Grove | Eighth | 42½ out |
| Sunday, September 1 |
| » Lost to Yankees (74-51), 6-4 | Braves Field (3-6) | 44-83 | Lost 2 |
| » Starters: Tom Zachary vs Bill Bayne | Eighth | 42½ out |
| Monday, September 2 |
| » Lost to Senators (58-68), 10-7 | Fenway Park (17-27) | 44-84 | Lost 3 |
| » Starters: Myles Thomas vs Danny MacFayden | Eighth | 43½ out |
| » Defeated Senators (58-69), 7-2 | Fenway Park (18-27) | 45-84 | |
| » Starters: Bump Hadley vs Milt Gaston | Eighth | 43½ out |
| Tuesday, September 3 |
| » Lost to Senators (59-69), 10-5 | Fenway Park (18-28) | 45-85 | |
| » Starters: Firpo Marberry vs Ed Morris | Eighth | 44½ out |
| Wednesday, September 4 |
| » Defeated Senators (59-70), 5-1 | Fenway Park (19-28) | 46-85 | |
| » Starters: Sam Jones vs Jack Russell | Eighth | 44 out |
| Saturday, September 7 |
| » Defeated Browns (67-62), 4-3 | Fenway Park (20-28) | 47-85 | Won 2 |
| » Starters: Alvin Crowder vs Red Ruffing | Eighth | 43½ out |
| Sunday, September 8 |
| » Defeated Browns (67-63), 4-3 | Braves Field (4-6) | 48-85 | Won 3 |
| » Starters: Dolly Gray vs Ed Morris | Eighth | 43 out |
| » Tied Browns, 0-0 | Braves Field (4-6) | 48-85 | |
| » Starters: George Blaeholder vs Milt Gaston | Eighth | 43 out |
| Monday, September 9 |
| » Defeated Browns (67-64), 6-2 | Fenway Park (21-28) | 49-85 | Won 4 |
| » Starters: Jack Ogden vs Danny MacFayden | Eighth | 42½ out |
| Tuesday, September 10 |
| » Lost to Browns (68-64), 6-1 | Fenway Park (21-29) | 49-86 | |
| » Starters: Rip Collins vs Jack Russell | Eighth | 44 out |
| » Lost to Browns (69-64), 1-0 | Fenway Park (21-30) | 49-87 | Lost 2 |
| » Starters: Dick Coffman vs Jack Russell | Eighth | 44 out |
| Wednesday, September 11 |
| » Defeated Tigers (62-73), 8-7 | Fenway Park (22-30) | 50-87 | |
| » Starters: Vic Sorrell vs Red Ruffing | Eighth | 44 out |
| Thursday, September 12 |
| » Lost to Tigers (63-73), 2-1 | Fenway Park (22-31) | 50-88 | |
| » Starters: Art Herring vs Ed Morris | Eighth | 45 out |
| Saturday, September 14 |
| » Lost to Tigers (64-73), 2-1 | Fenway Park (22-32) | 50-89 | Lost 2 |
| » Starters: Ownie Carroll vs Milt Gaston | Eighth | 46½ out |
| Sunday, September 15 |
| » Defeated White Sox (53-83), 5-4 | Braves Field (5-6) | 51-89 | |
| » Starters: Ted Lyons vs Danny MacFayden | Eighth | 46½ out |
| » Lost to White Sox (54-83), 3-2 | Braves Field (5-7) | 51-90 | |
| » Starters: Hal McKain vs Jack Russell | Eighth | 46½ out |
| Monday, September 16 |
| » Defeated White Sox (54-84), 4-3 | Fenway Park (23-32) | 52-90 | |
| » Starters: Tommy Thomas vs Red Ruffing | Eighth | 45½ out |
| Tuesday, September 17 |
| » Defeated White Sox (54-85), 6-4 | Fenway Park (24-32) | 53-90 | Won 2 |
| » Starters: Ed Walsh vs Ed Carroll | Eighth | 45 out |
| Thursday, September 19 |
| » Defeated Indians (74-67), 3-2 | Fenway Park (25-32) | 54-90 | Won 3 |
| » Starters: Willis Hudlin vs Milt Gaston | Eighth | 45 out |
| Friday, September 20 |
| » Lost to Indians (75-67), 4-2 | Fenway Park (25-33) | 54-91 | |
| » Starters: Ken Holloway vs Danny MacFayden | Eighth | 46 out |
| » Major-league debuts: Joe Cicero and Ed Connolly (Red Sox) |
| Saturday, September 21 |
| » Defeated Indians (75-68), 4-3 | Fenway Park (26-33) | 55-91 | |
| » Starters: Johnny Miljus vs Jack Russell | Seventh | 46 out |
| Sunday, September 22 |
| » Lost to Indians (76-68), 7-4 | Braves Field (5-8) | 55-92 | |
| » Starters: Wes Ferrell vs Ed Carroll | Eighth | 46 out |
| Tuesday, September 24 |
| » Lost to Yankees (85-62), 5-3 | Fenway Park (26-34) | 55-93 | Lost 2 |
| » Starters: Tom Zachary vs Bill Bayne | Eighth | 46½ out |
| Wednesday, September 25 |
| » Lost to Yankees (86-62), 11-10 | Fenway Park (26-35) | 55-94 | Lost 3 |
| » Starters: Bots Nekola vs Ray Dobens | Eighth | 47 out |
| Thursday, September 26 |
| » Lost to Athletics (101-45), 5-3 | Fenway Park (26-36) | 55-95 | Lost 4 |
| » Starters: George Earnshaw vs Jack Russell | Eighth | 48 out |
| Saturday, September 28 |
| » Lost to Athletics (102-45), 6-3 | Fenway Park (26-37) | 55-96 | Lost 5 |
| » Starters: Bill Shores vs Danny MacFayden | Eighth | 49 out |
| Sunday, September 29 |
| » Defeated Athletics (102-46), 10-0 | Braves Field (6-8) | 56-96 | |
| » Starters: Lefty Grove vs Red Ruffing | Eighth | 48 out |
| Saturday, October 5 |
| » Defeated Senators (71-80), 4-3 | Griffith Stadium (3-7) | 57-96 | Won 2 |
| » Starters: Milt Gaston vs Firpo Marberry | Eighth | 48 out |
| Sunday, October 6 |
| » Defeated Senators (71-81), 2-1 | Griffith Stadium (4-7) | 58-96 | Won 3 |
| » Starters: Ed Durham vs Ad Liska | Eighth | 48 out |
| Wednesday, October 9 |
| Former Red Sox Red Kleinow dies in New York, NY at the age of 51. |
| Monday, November 11 |
| Future Red Sox Ike Delock is born in Highland Park, MI. |
| Thursday, November 14 |
| Future Red Sox Jimmy Piersall is born in Waterbury, CT. |
| Sunday, November 17 |
| Future Red Sox Norm Zauchin is born in Royal Oak, MI. |
| Wednesday, November 20 |
| Future Red Sox Lou Berberet is born in Long Beach, CA. |
| Saturday, November 30 |
| Future Red Sox Leo Kiely is born in Hoboken, NJ. |
| Wednesday, December 11 |
| Former Red Sox Doc McMahon dies in Woburn, MA at the age of 43. |
Game information provided by Retrosheet (www.retrosheet.org) |