| Thursday, January 3 |
| Former Indian Charlie Smith dies in Wickliffe, OH at the age of 49. |
| Friday, January 11 |
| Future Indian Don Mossi is born in St. Helena, CA. |
| Monday, February 18 |
| Future Indian Cal Neeman is born in Valmeyer, IL. |
| Thursday, March 7 |
| Future Indian Red Wilson is born in Milwaukee, WI. |
| Tuesday, April 16 |
| » Defeated Tigers (0-1), 5-4 | League Park II (1-0) | 1-0 | |
| » Starters: Earl Whitehill vs Joe Shaute | First | -- |
| » Major-league debuts: Earl Averill (Indians) Dale Alexander (Tigers) |
| Wednesday, April 17 |
| » Lost to Tigers (1-1), 15-3 | League Park II (1-1) | 1-1 | |
| » Starters: George Uhle vs Ken Holloway | Fourth | 1 out |
| Thursday, April 18 |
| » Defeated Tigers (1-2), 8-4 | League Park II (2-1) | 2-1 | |
| » Starters: Ownie Carroll vs Johnny Miljus | Fourth | 1 out |
| » Major-league debuts: Frank Barnes and Roy Johnson (Tigers) |
| Friday, April 19 |
| » Defeated Tigers (1-3), 7-4 | League Park II (3-1) | 3-1 | Won 2 |
| » Starters: Vic Sorrell vs Willis Hudlin | Second | 1 out |
| Monday, April 22 |
| » Lost to White Sox (2-3), 10-0 | League Park II (3-2) | 3-2 | |
| » Starters: Tommy Thomas vs Joe Shaute | Third | ½ out |
| Tuesday, April 23 |
| » Defeated White Sox (2-4), 5-4 | League Park II (4-2) | 4-2 | |
| » Starters: Grady Adkins vs Jake Miller | First | -- |
| Wednesday, April 24 |
| » Lost to Tigers (4-5), 7-6 | Tiger Stadium (0-1) | 4-3 | |
| » Starters: Johnny Miljus vs Vic Sorrell | Fourth | ½ out |
| Thursday, April 25 |
| » Lost to Tigers (5-5), 5-0 | Tiger Stadium (0-2) | 4-4 | Lost 2 |
| » Starters: Willis Hudlin vs Emil Yde | Fourth | 1½ out |
| Friday, April 26 |
| » Defeated Tigers (5-6), 11-5 | Tiger Stadium (1-2) | 5-4 | |
| » Starters: Wes Ferrell vs Earl Whitehill | Third | 1 out |
| Saturday, April 27 |
| » Lost to White Sox (3-6), 7-1 | Comiskey Park I (0-1) | 5-5 | |
| » Starters: Joe Shaute vs Tommy Thomas | Fourth | 1½ out |
| Sunday, April 28 |
| » Lost to White Sox (4-6), 2-1 | Comiskey Park I (0-2) | 5-6 | Lost 2 |
| » Starters: Jake Miller vs Grady Adkins | Fifth | 2½ out |
| Monday, April 29 |
| » Lost to White Sox (5-6), 13-4 | Comiskey Park I (0-3) | 5-7 | Lost 3 |
| » Starters: Johnny Miljus vs Ted Lyons | Sixth | 3 out |
| Future Indian Steve Ridzik is born in Yonkers, NY. |
| Tuesday, April 30 |
| » Lost to White Sox (6-6), 8-4 | Comiskey Park I (0-4) | 5-8 | Lost 4 |
| » Starters: Willis Hudlin vs Bob Weiland | Seventh | 4½ out |
| Wednesday, May 1 |
| » Lost to Browns (11-4), 4-3 | League Park II (4-3) | 5-9 | Lost 5 |
| » Starters: Alvin Crowder vs Wes Ferrell | Seventh | 5½ out |
| Saturday, May 4 |
| » Defeated Senators (3-8), 4-3 | League Park II (5-3) | 6-9 | |
| » Starters: Bump Hadley vs Joe Shaute | Sixth | 5 out |
| Sunday, May 5 |
| » Defeated Senators (3-9), 1-0 | League Park II (6-3) | 7-9 | Won 2 |
| » Starters: Ad Liska vs Jake Miller | Fifth | 4 out |
| Monday, May 6 |
| » Lost to Senators (4-9), 13-5 | League Park II (6-4) | 7-10 | |
| » Starters: Garland Braxton vs Ken Holloway | Fifth | 4½ out |
| Tuesday, May 7 |
| » Lost to Red Sox (5-10), 5-4 | League Park II (6-5) | 7-11 | Lost 2 |
| » Starters: Jack Russell vs Wes Ferrell | Sixth | 5 out |
| Future Indian Dick Williams is born in St. Louis, MO. |
| Wednesday, May 8 |
| » Defeated Red Sox (5-11), 3-1 | League Park II (7-5) | 8-11 | |
| » Starters: Danny MacFayden vs Willis Hudlin | Fifth | 5 out |
| Thursday, May 9 |
| » Defeated Red Sox (5-12), 4-3 | League Park II (8-5) | 9-11 | Won 2 |
| » Starters: Milt Gaston vs Joe Shaute | Fifth | 5 out |
| Friday, May 10 |
| » Defeated Athletics (12-6), 9-0 | League Park II (9-5) | 10-11 | Won 3 |
| » Starters: Rube Walberg vs Jake Miller | Fifth | 5 out |
| Saturday, May 11 |
| » Lost to Athletics (13-6), 4-2 | League Park II (9-6) | 10-12 | |
| » Starters: Lefty Grove vs Johnny Miljus | Fifth | 5 out |
| Monday, May 13 |
| » Defeated Yankees (13-7), 4-3 | League Park II (10-6) | 11-12 | |
| » Starters: Fred Heimach vs Willis Hudlin | Fourth | 3½ out |
| Wednesday, May 15 |
| » Defeated Yankees (13-8), 7-1 | League Park II (11-6) | 12-12 | Won 2 |
| » Starters: George Pipgras vs Joe Shaute | Fifth | 3 out |
| Thursday, May 16 |
| » Lost to Browns (15-10), 1-0 | Sportsman's Park III (0-1) | 12-13 | |
| » Starters: Jake Miller vs Alvin Crowder | Fifth | 3½ out |
| Friday, May 17 |
| » Lost to Browns (16-10), 7-6 | Sportsman's Park III (0-2) | 12-14 | Lost 2 |
| » Starters: Johnny Miljus vs Jack Ogden | Fifth | 4½ out |
| Sunday, May 19 |
| » Defeated Browns (16-11), 10-6 | Sportsman's Park III (1-2) | 13-14 | |
| » Starters: Joe Shaute vs Lefty Stewart | Fifth | 5½ out |
| Tuesday, May 21 |
| » Lost to Tigers (19-14), 2-1 | Tiger Stadium (1-3) | 13-15 | |
| » Starters: Willis Hudlin vs Ownie Carroll | Fifth | 6½ out |
| Wednesday, May 22 |
| » Defeated Tigers (19-15), 7-4 | Tiger Stadium (2-3) | 14-15 | |
| » Starters: Jake Miller vs Earl Whitehill | Fifth | 6½ out |
| Thursday, May 23 |
| » Defeated Browns (19-12), 5-4 | League Park II (12-6) | 15-15 | Won 2 |
| » Starters: Lefty Stewart vs Joe Shaute | Fifth | 7½ out |
| » Lost to Browns (20-12), 7-5 | League Park II (12-7) | 15-16 | |
| » Starters: George Blaeholder vs Wes Ferrell | Fifth | 7½ out |
| Friday, May 24 |
| » Lost to Browns (21-12), 5-0 | League Park II (12-8) | 15-17 | Lost 2 |
| » Starters: Dolly Gray vs Jimmy Zinn | Fifth | 8½ out |
| Saturday, May 25 |
| » Defeated Browns (21-13), 5-1 | League Park II (13-8) | 16-17 | |
| » Starters: Alvin Crowder vs Ken Holloway | Fifth | 8½ out |
| Sunday, May 26 |
| » Lost to Browns (22-13), 1-0 | League Park II (13-9) | 16-18 | |
| » Starters: Rip Collins vs Willis Hudlin | Fifth | 9½ out |
| Monday, May 27 |
| » Lost to Browns (23-13), 3-1 | League Park II (13-10) | 16-19 | Lost 2 |
| » Starters: George Blaeholder vs Jake Miller | Fifth | 10 out |
| Tuesday, May 28 |
| » Defeated White Sox (15-24), 5-2 | Comiskey Park I (1-4) | 17-19 | |
| » Starters: Joe Shaute vs Dan Dugan | Fifth | 9 out |
| Wednesday, May 29 |
| » Defeated White Sox (15-25), 11-1 | Comiskey Park I (2-4) | 18-19 | Won 2 |
| » Starters: Jimmy Zinn vs Tommy Thomas | Fifth | 9 out |
| Thursday, May 30 |
| » Defeated White Sox (15-26), 6-5 | Comiskey Park I (3-4) | 19-19 | Won 3 |
| » Starters: Willis Hudlin vs Ted Lyons | Fifth | 10 out |
| » Lost to White Sox (16-26), 3-2 | Comiskey Park I (3-5) | 19-20 | |
| » Starters: Ken Holloway vs Red Faber | Fifth | 10 out |
| Saturday, June 1 |
| » Defeated Red Sox (11-28), 3-2 | Fenway Park (1-0) | 20-20 | |
| » Starters: Jake Miller vs Ed Morris | Fifth | 10½ out |
| Sunday, June 2 |
| » Lost to Red Sox (12-28), 12-3 | Braves Field (0-1) | 20-21 | |
| » Starters: Joe Shaute vs Milt Gaston | Fifth | 11 out |
| Tuesday, June 4 |
| » Defeated Red Sox (12-29), 4-0 | Fenway Park (2-0) | 21-21 | |
| » Starters: Jimmy Zinn vs Red Ruffing | Fifth | 10½ out |
| Wednesday, June 5 |
| » Lost to Yankees (25-16), 6-5 | Yankee Stadium (0-1) | 21-22 | |
| » Starters: Joe Shaute vs Waite Hoyt | Fifth | 11½ out |
| Thursday, June 6 |
| » Defeated Yankees (25-17), 9-7 | Yankee Stadium (1-1) | 22-22 | |
| » Starters: Jake Miller vs George Pipgras | Fifth | 11½ out |
| Friday, June 7 |
| » Defeated Yankees (25-18), 7-3 | Yankee Stadium (2-1) | 23-22 | Won 2 |
| » Starters: Willis Hudlin vs Ed Wells | Fifth | 10½ out |
| Sunday, June 9 |
| » Lost to Senators (17-27), 5-2 | Griffith Stadium (0-1) | 23-23 | |
| » Starters: Johnny Miljus vs Ad Liska | Fifth | 11 out |
| Monday, June 10 |
| » Defeated Senators (17-28), 4-3 | Griffith Stadium (1-1) | 24-23 | |
| » Starters: Joe Shaute vs Bump Hadley | Fifth | 11 out |
| Future Indian Hank Foiles is born in Richmond, VA. |
| Tuesday, June 11 |
| » Lost to Senators (18-28), 13-3 | Griffith Stadium (1-2) | 24-24 | |
| » Starters: Jake Miller vs Firpo Marberry | Fifth | 12 out |
| Wednesday, June 12 |
| » Defeated Senators (18-29), 9-5 | Griffith Stadium (2-2) | 25-24 | |
| » Starters: Willis Hudlin vs Bobby Burke | Fifth | 12 out |
| Thursday, June 13 |
| » Lost to Athletics (37-11), 10-3 | Shibe Park (0-1) | 25-25 | |
| » Starters: Jimmy Zinn vs Eddie Rommel | Fifth | 13 out |
| Friday, June 14 |
| » Lost to Athletics (38-11), 9-0 | Shibe Park (0-2) | 25-26 | Lost 2 |
| » Starters: Ken Holloway vs Lefty Grove | Fifth | 14 out |
| Saturday, June 15 |
| » Lost to Athletics (39-11), 1-0 | Shibe Park (0-3) | 25-27 | Lost 3 |
| » Starters: Willis Hudlin vs George Earnshaw | Fifth | 15 out |
| Sunday, June 16 |
| » Defeated Athletics (39-12), 10-9 | League Park II (14-10) | 26-27 | |
| » Starters: Rube Walberg vs Jake Miller | Fifth | 14 out |
| Wednesday, June 19 |
| » Lost to Tigers (32-29), 8-3 | League Park II (14-11) | 26-28 | |
| » Starters: Emil Yde vs Willis Hudlin | Fifth | 14½ out |
| Future Indian Don Ferrarese is born in Oakland, CA. |
| Thursday, June 20 |
| » Lost to Tigers (33-29), 8-4 | League Park II (14-12) | 26-29 | Lost 2 |
| » Starters: Vic Sorrell vs Jimmy Zinn | Fifth | 15 out |
| Saturday, June 22 |
| » Defeated Tigers (33-30), 4-3 | League Park II (15-12) | 27-29 | |
| » Starters: Ownie Carroll vs Wes Ferrell | Fifth | 14½ out |
| Sunday, June 23 |
| » Lost to Tigers (34-30), 8-7 | League Park II (15-13) | 27-30 | |
| » Starters: George Uhle vs Willis Hudlin | Fourth | 15½ out |
| Monday, June 24 |
| » Defeated Browns (35-25), 10-4 | Sportsman's Park III (2-2) | 28-30 | |
| » Starters: Jake Miller vs Alvin Crowder | Fifth | 15½ out |
| Tuesday, June 25 |
| » Defeated Browns (35-26), 10-7 | Sportsman's Park III (3-2) | 29-30 | Won 2 |
| » Starters: Jimmy Zinn vs George Blaeholder | Fifth | 16½ out |
| » Lost to Browns (36-26), 8-0 | Sportsman's Park III (3-3) | 29-31 | |
| » Starters: Joe Shaute vs Lefty Stewart | Fifth | 16½ out |
| Wednesday, June 26 |
| » Lost to Browns (37-26), 6-2 | Sportsman's Park III (3-4) | 29-32 | Lost 2 |
| » Starters: Willis Hudlin vs Rip Collins | Fifth | 17½ out |
| Thursday, June 27 |
| » Lost to Tigers (37-31), 6-2 | Tiger Stadium (2-4) | 29-33 | Lost 3 |
| » Starters: Wes Ferrell vs Ownie Carroll | Fifth | 18½ out |
| Friday, June 28 |
| » Defeated Tigers (37-32), 5-4 | Tiger Stadium (3-4) | 30-33 | |
| » Starters: Johnny Miljus vs George Uhle | Fifth | 18 out |
| Saturday, June 29 |
| » Defeated Tigers (37-33), 12-9 | Tiger Stadium (4-4) | 31-33 | Won 2 |
| » Starters: Jake Miller vs Emil Yde | Fifth | 17 out |
| Sunday, June 30 |
| » Lost to Tigers (38-33), 11-10 | Tiger Stadium (4-5) | 31-34 | |
| » Starters: Jimmy Zinn vs Vic Sorrell | Fifth | 17 out |
| Tuesday, July 2 |
| » Defeated White Sox (23-47), 4-3 | League Park II (16-13) | 32-34 | |
| » Starters: Tommy Thomas vs Joe Shaute | Fifth | 17 out |
| » Defeated White Sox (23-48), 5-4 | League Park II (17-13) | 33-34 | Won 2 |
| » Starters: Bob Weiland vs Willis Hudlin | Fifth | 17 out |
| Wednesday, July 3 |
| » Lost to White Sox (24-48), 6-3 | League Park II (17-14) | 33-35 | |
| » Starters: Ed Walsh vs Wes Ferrell | Fifth | 18 out |
| Thursday, July 4 |
| » Lost to White Sox (25-48), 9-2 | League Park II (17-15) | 33-36 | Lost 2 |
| » Starters: Red Faber vs Jake Miller | Fifth | 19 out |
| » Defeated White Sox (25-49), 12-5 | League Park II (18-15) | 34-36 | |
| » Starters: Ted Lyons vs Johnny Miljus | Fifth | 19 out |
| Future Indian Chuck Tanner is born in New Castle, PA. |
| Friday, July 5 |
| » Defeated White Sox (25-50), 11-10 | League Park II (19-15) | 35-36 | Won 2 |
| » Starters: Bob Weiland vs Jimmy Zinn | Fifth | 18½ out |
| Sunday, July 7 |
| » Defeated Red Sox (22-54), 4-2 | League Park II (20-15) | 36-36 | Won 3 |
| » Starters: Red Ruffing vs Willis Hudlin | Fifth | 17½ out |
| » Lost to Red Sox (23-54), 3-0 | League Park II (20-16) | 36-37 | |
| » Starters: Ed Morris vs Wes Ferrell | Fifth | 17½ out |
| Monday, July 8 |
| » Defeated Red Sox (23-55), 5-2 | League Park II (21-16) | 37-37 | |
| » Starters: Danny MacFayden vs Joe Shaute | Fifth | 17½ out |
| Future Indian John Powers is born in Birmingham, AL. |
| Tuesday, July 9 |
| Future Indian Wally Post is born in St. Wendelin, OH. |
| Wednesday, July 10 |
| » Defeated Senators (28-45), 9-7 | League Park II (22-16) | 38-37 | Won 2 |
| » Starters: Lloyd Brown vs Johnny Miljus | Fifth | 16½ out |
| Thursday, July 11 |
| » Lost to Senators (29-45), 9-3 | League Park II (22-17) | 38-38 | |
| » Starters: Firpo Marberry vs Jimmy Zinn | Fifth | 17 out |
| Friday, July 12 |
| » Defeated Senators (29-46), 3-2 | League Park II (23-17) | 39-38 | |
| » Starters: Myles Thomas vs Joe Shaute | Fifth | 17½ out |
| Saturday, July 13 |
| » Defeated Senators (29-47), 6-1 | League Park II (24-17) | 40-38 | Won 2 |
| » Starters: Sam Jones vs Jake Miller | Fifth | 17 out |
| Sunday, July 14 |
| » Lost to Athletics (59-22), 5-3 | League Park II (24-18) | 40-39 | |
| » Starters: Carroll Yerkes vs Willis Hudlin | Fifth | 18 out |
| Monday, July 15 |
| » Defeated Athletics (59-23), 8-5 | League Park II (25-18) | 41-39 | |
| » Starters: Howard Ehmke vs Wes Ferrell | Fifth | 18 out |
| » Lost to Athletics (60-23), 4-0 | League Park II (25-19) | 41-40 | |
| » Starters: George Earnshaw vs Johnny Miljus | Fifth | 18 out |
| Tuesday, July 16 |
| » Lost to Athletics (61-23), 7-5 | League Park II (25-20) | 41-41 | Lost 2 |
| » Starters: Lefty Grove vs Joe Shaute | Fifth | 19 out |
| Wednesday, July 17 |
| » Defeated Athletics (61-24), 5-2 | League Park II (26-20) | 42-41 | |
| » Starters: Bill Shores vs Jake Miller | Fifth | 18 out |
| Friday, July 19 |
| » Lost to Yankees (52-30), 7-2 | League Park II (26-21) | 42-42 | |
| » Starters: Tom Zachary vs Willis Hudlin | Fifth | 19 out |
| » Defeated Yankees (52-31), 11-3 | League Park II (27-21) | 43-42 | |
| » Starters: George Pipgras vs Wes Ferrell | Fifth | 19 out |
| » Major-league debuts: Bots Nekola (Yankees) |
| Saturday, July 20 |
| » Defeated Yankees (52-32), 8-4 | League Park II (28-21) | 44-42 | Won 2 |
| » Starters: Herb Pennock vs Joe Shaute | Fifth | 19½ out |
| » Lost to Yankees (53-32), 11-6 | League Park II (28-22) | 44-43 | |
| » Starters: Roy Sherid vs Johnny Miljus | Fifth | 19½ out |
| » Major-league debuts: Milt Shoffner (Indians) |
| Sunday, July 21 |
| » Defeated Yankees (53-33), 6-4 | League Park II (29-22) | 45-43 | |
| » Starters: Waite Hoyt vs Jake Miller | Fourth | 19½ out |
| Tuesday, July 23 |
| » Lost to Athletics (66-24), 4-1 | Shibe Park (0-4) | 45-44 | |
| » Starters: Willis Hudlin vs Rube Walberg | Fourth | 19½ out |
| » Defeated Athletics (66-25), 9-3 | Shibe Park (1-4) | 46-44 | |
| » Starters: Wes Ferrell vs Bill Shores | Fourth | 19½ out |
| Wednesday, July 24 |
| » Lost to Athletics (67-25), 5-3 | Shibe Park (1-5) | 46-45 | |
| » Starters: Joe Shaute vs George Earnshaw | Fourth | 20½ out |
| Thursday, July 25 |
| » Lost to Athletics (68-25), 21-3 | Shibe Park (1-6) | 46-46 | Lost 2 |
| » Starters: Johnny Miljus vs Lefty Grove | Fourth | 21½ out |
| Friday, July 26 |
| » Defeated Senators (35-54), 4-2 | Griffith Stadium (3-2) | 47-46 | |
| » Starters: Jake Miller vs Sam Jones | Fourth | 21½ out |
| Saturday, July 27 |
| » Defeated Senators (35-55), 5-3 | Griffith Stadium (4-2) | 48-46 | Won 2 |
| » Starters: Willis Hudlin vs Garland Braxton | Fourth | 21½ out |
| Sunday, July 28 |
| » Defeated Senators (35-56), 9-6 | Griffith Stadium (5-2) | 49-46 | Won 3 |
| » Starters: Joe Shaute vs Bobby Burke | Fourth | 21 out |
| Tuesday, July 30 |
| » Defeated Red Sox (28-67), 11-4 | Fenway Park (3-0) | 50-46 | Won 4 |
| » Starters: Wes Ferrell vs Ed Morris | Fourth | 20½ out |
| Wednesday, July 31 |
| » Lost to Red Sox (29-67), 4-0 | Fenway Park (3-1) | 50-47 | |
| » Starters: Jake Miller vs Danny MacFayden | Fourth | 21 out |
| » Defeated Red Sox (29-68), 6-2 | Fenway Park (4-1) | 51-47 | |
| » Starters: Willis Hudlin vs Milt Gaston | Fourth | 21 out |
| Thursday, August 1 |
| » Defeated Red Sox (29-69), 10-3 | Fenway Park (5-1) | 52-47 | Won 2 |
| » Starters: Jimmy Zinn vs Red Ruffing | Fourth | 21 out |
| Friday, August 2 |
| » Defeated Yankees (60-35), 9-8 | Yankee Stadium (3-1) | 53-47 | Won 3 |
| » Starters: Joe Shaute vs George Pipgras | Fourth | 21 out |
| Sunday, August 4 |
| » Lost to Yankees (61-35), 12-0 | Yankee Stadium (3-2) | 53-48 | |
| » Starters: Jake Miller vs Tom Zachary | Fourth | 21 out |
| » Defeated Yankees (61-36), 14-6 | Yankee Stadium (4-2) | 54-48 | |
| » Starters: Wes Ferrell vs Herb Pennock | Fourth | 21 out |
| Tuesday, August 6 |
| » Defeated Tigers (49-54), 6-5 | League Park II (30-22) | 55-48 | Won 2 |
| » Starters: Vic Sorrell vs Willis Hudlin | Third | 20½ out |
| Wednesday, August 7 |
| » Lost to Tigers (50-54), 14-4 | League Park II (30-23) | 55-49 | |
| » Starters: Ownie Carroll vs Joe Shaute | Fourth | 21 out |
| Thursday, August 8 |
| » Lost to Tigers (51-54), 9-6 | League Park II (30-24) | 55-50 | Lost 2 |
| » Starters: Skinny Graham vs Johnny Miljus | Third | 21 out |
| Saturday, August 10 |
| » Lost to Yankees (65-38), 4-2 | League Park II (30-25) | 55-51 | Lost 3 |
| » Starters: Tom Zachary vs Jake Miller | Fourth | 22 out |
| Sunday, August 11 |
| » Defeated Yankees (65-39), 6-5 | League Park II (31-25) | 56-51 | |
| » Starters: Ed Wells vs Willis Hudlin | Third | 21 out |
| Monday, August 12 |
| » Defeated Yankees (65-40), 11-7 | League Park II (32-25) | 57-51 | Won 2 |
| » Starters: George Pipgras vs Joe Shaute | Third | 21 out |
| Tuesday, August 13 |
| » Defeated Yankees (65-41), 3-2 | League Park II (33-25) | 58-51 | Won 3 |
| » Starters: Fred Heimach vs Wes Ferrell | Third | 21 out |
| Wednesday, August 14 |
| » Lost to Athletics (81-31), 5-3 | League Park II (33-26) | 58-52 | |
| » Starters: Lefty Grove vs Jake Miller | Third | 22 out |
| Friday, August 16 |
| » Lost to Athletics (82-31), 6-5 | League Park II (33-27) | 58-53 | Lost 2 |
| » Starters: George Earnshaw vs Joe Shaute | Third | 23 out |
| Saturday, August 17 |
| » Defeated Athletics (82-32), 2-1 | League Park II (34-27) | 59-53 | |
| » Starters: Rube Walberg vs Wes Ferrell | Third | 22 out |
| Sunday, August 18 |
| » Defeated Senators (48-63), 8-1 | League Park II (35-27) | 60-53 | Won 2 |
| » Starters: Garland Braxton vs Willis Hudlin | Third | 21 out |
| Monday, August 19 |
| » Lost to Senators (49-63), 5-3 | League Park II (35-28) | 60-54 | |
| » Starters: Sam Jones vs Jake Miller | Third | 22 out |
| Tuesday, August 20 |
| » Lost to Senators (50-63), 6-2 | League Park II (35-29) | 60-55 | Lost 2 |
| » Starters: Bobby Burke vs Milt Shoffner | Third | 22 out |
| Wednesday, August 21 |
| » Defeated Senators (50-64), 3-1 | League Park II (36-29) | 61-55 | |
| » Starters: Lloyd Brown vs Wes Ferrell | Third | 21 out |
| Friday, August 23 |
| » Lost to Red Sox (41-76), 8-5 | League Park II (36-30) | 61-56 | |
| » Starters: Danny MacFayden vs Willis Hudlin | Fourth | 20½ out |
| Saturday, August 24 |
| » Lost to Red Sox (42-76), 5-2 | League Park II (36-31) | 61-57 | Lost 2 |
| » Starters: Ed Morris vs Jake Miller | Fourth | 21 out |
| » Defeated Red Sox (42-77), 6-2 | League Park II (37-31) | 62-57 | |
| » Starters: Milt Gaston vs Ken Holloway | Fourth | 21 out |
| Sunday, August 25 |
| » Defeated Red Sox (42-78), 5-4 | League Park II (38-31) | 63-57 | Won 2 |
| » Starters: Jack Russell vs Wes Ferrell | Fourth | 20½ out |
| » Lost to Red Sox (43-78), 5-3 | League Park II (38-32) | 63-58 | |
| » Starters: Red Ruffing vs Jimmy Zinn | Fourth | 20½ out |
| Thursday, August 29 |
| » Lost to White Sox (50-73), 2-1 | Comiskey Park I (3-6) | 63-59 | Lost 2 |
| » Starters: Willis Hudlin vs Ted Lyons | Fourth | 21½ out |
| Saturday, August 31 |
| » Defeated White Sox (50-74), 8-5 | Comiskey Park I (4-6) | 64-59 | |
| » Starters: Wes Ferrell vs Hal McKain | Fourth | 21 out |
| Sunday, September 1 |
| » Defeated White Sox (50-75), 5-0 | Comiskey Park I (5-6) | 65-59 | Won 2 |
| » Starters: Ken Holloway vs Tommy Thomas | Fourth | 20 out |
| Monday, September 2 |
| » Defeated Browns (66-60), 2-1 | League Park II (39-32) | 66-59 | Won 3 |
| » Starters: Dolly Gray vs Jake Miller | Third | 20 out |
| » Defeated Browns (66-61), 9-5 | League Park II (40-32) | 67-59 | Won 4 |
| » Starters: Alvin Crowder vs Willis Hudlin | Third | 20 out |
| Wednesday, September 4 |
| » Defeated Tigers (60-68), 7-2 | Tiger Stadium (5-5) | 68-59 | Won 5 |
| » Starters: Wes Ferrell vs Earl Whitehill | Third | 20 out |
| Thursday, September 5 |
| » Defeated Tigers (60-69), 4-0 | Tiger Stadium (6-5) | 69-59 | Won 6 |
| » Starters: Ken Holloway vs Phil Page | Third | 19½ out |
| Saturday, September 7 |
| » Lost to Athletics (91-41), 5-1 | Shibe Park (1-7) | 69-60 | |
| » Starters: Jake Miller vs Lefty Grove | Third | 19½ out |
| » Defeated Athletics (91-42), 4-0 | Shibe Park (2-7) | 70-60 | |
| » Starters: Willis Hudlin vs Rube Walberg | Third | 19½ out |
| Tuesday, September 10 |
| » Lost to Athletics (92-42), 6-5 | Shibe Park (2-8) | 70-61 | |
| » Starters: Wes Ferrell vs George Earnshaw | Third | 20½ out |
| Wednesday, September 11 |
| » Lost to Senators (61-72), 5-2 | Griffith Stadium (5-3) | 70-62 | Lost 2 |
| » Starters: Willis Hudlin vs Firpo Marberry | Third | 21½ out |
| Thursday, September 12 |
| » Defeated Senators (61-73), 5-1 | Griffith Stadium (6-3) | 71-62 | |
| » Starters: Jake Miller vs Myles Thomas | Third | 21½ out |
| Friday, September 13 |
| » Lost to Senators (62-73), 4-3 | Griffith Stadium (6-4) | 71-63 | |
| » Starters: Milt Shoffner vs Sam Jones | Third | 22½ out |
| Saturday, September 14 |
| » Defeated Senators (62-74), 4-1 | Griffith Stadium (7-4) | 72-63 | |
| » Starters: Wes Ferrell vs Lloyd Brown | Third | 22½ out |
| Sunday, September 15 |
| » Lost to Yankees (80-58), 1-0 | Yankee Stadium (4-3) | 72-64 | |
| » Starters: Ken Holloway vs Tom Zachary | Third | 22½ out |
| » Defeated Yankees (80-59), 10-0 | Yankee Stadium (5-3) | 73-64 | |
| » Starters: Willis Hudlin vs Waite Hoyt | Third | 22½ out |
| Monday, September 16 |
| » Defeated Yankees (80-60), 4-2 | Yankee Stadium (6-3) | 74-64 | Won 2 |
| » Starters: Johnny Miljus vs Ed Wells | Third | 21½ out |
| Wednesday, September 18 |
| » Lost to Yankees (81-60), 9-7 | Yankee Stadium (6-4) | 74-65 | |
| » Starters: Jake Miller vs Herb Pennock | Third | 22½ out |
| » Lost to Yankees (82-60), 12-2 | Yankee Stadium (6-5) | 74-66 | Lost 2 |
| » Starters: Wes Ferrell vs Roy Sherid | Third | 22½ out |
| Thursday, September 19 |
| » Lost to Red Sox (54-90), 3-2 | Fenway Park (5-2) | 74-67 | Lost 3 |
| » Starters: Willis Hudlin vs Milt Gaston | Third | 23½ out |
| Friday, September 20 |
| » Defeated Red Sox (54-91), 4-2 | Fenway Park (6-2) | 75-67 | |
| » Starters: Ken Holloway vs Danny MacFayden | Third | 23½ out |
| » Major-league debuts: Joe Cicero and Ed Connolly (Red Sox) |
| Saturday, September 21 |
| » Lost to Red Sox (55-91), 4-3 | Fenway Park (6-3) | 75-68 | |
| » Starters: Johnny Miljus vs Jack Russell | Third | 24½ out |
| Sunday, September 22 |
| » Defeated Red Sox (55-92), 7-4 | Braves Field (1-1) | 76-68 | |
| » Starters: Wes Ferrell vs Ed Carroll | Third | 23½ out |
| Tuesday, September 24 |
| » Defeated White Sox (56-89), 7-4 | League Park II (41-32) | 77-68 | Won 2 |
| » Starters: Ted Lyons vs Willis Hudlin | Third | 23 out |
| Wednesday, September 25 |
| » Defeated White Sox (56-90), 9-7 | League Park II (42-32) | 78-68 | Won 3 |
| » Starters: Ed Walsh vs Ken Holloway | Third | 22½ out |
| Friday, September 27 |
| Former Indian Johnny Gochnauer dies in Altoona, PA at the age of 55. |
| Saturday, September 28 |
| » Defeated Browns (76-71), 4-1 | League Park II (43-32) | 79-68 | Won 4 |
| » Starters: Lefty Stewart vs Jake Miller | Third | 23 out |
| Sunday, September 29 |
| » Defeated Browns (76-72), 4-0 | League Park II (44-32) | 80-68 | Won 5 |
| » Starters: George Blaeholder vs Wes Ferrell | Third | 22 out |
| Thursday, October 3 |
| » Lost to Browns (77-72), 3-2 | Sportsman's Park III (3-5) | 80-69 | |
| » Starters: Willis Hudlin vs Alvin Crowder | Third | 22½ out |
| Saturday, October 5 |
| » Defeated Browns (77-73), 3-2 | Sportsman's Park III (4-5) | 81-69 | |
| » Starters: Wes Ferrell vs Dolly Gray | Third | 22½ out |
| Sunday, October 6 |
| » Lost to Browns (78-73), 4-2 | Sportsman's Park III (4-6) | 81-70 | |
| » Starters: Clint Brown vs Fred Stiely | Third | 24 out |
| » Lost to Browns (79-73), 4-1 | Sportsman's Park III (4-7) | 81-71 | Lost 2 |
| » Starters: Milt Shoffner vs Chad Kimsey | Third | 24 out |
| Thursday, October 10 |
| Future Indian Bobby Tiefenauer is born in Desloge, MO. |
| Thursday, November 14 |
| Future Indian Jimmy Piersall is born in Waterbury, CT. |
| Saturday, December 14 |
| Future Indian Pete Whisenant is born in Asheville, NC. |
| Monday, December 23 |
| Future Indian Al Cicotte is born in Melvindale, MI. |
Game information provided by Retrosheet (www.retrosheet.org) |
