| Friday, January 11 |
| Future Athletic Don Mossi is born in St. Helena, CA. |
| Thursday, January 31 |
| Future Athletic Duke Maas is born in Utica, MI. |
| Friday, February 22 |
| Future Athletic Ryne Duren is born in Cazenovia, WI. |
| Wednesday, April 17 |
| » Defeated Senators (0-1), 13-4 | Griffith Stadium (1-0) | 1-0 | |
| » Starters: Carroll Yerkes vs Sam Jones | Second | ½ out |
| » Major-league debuts: Ad Liska (Senators) |
| Thursday, April 18 |
| » Defeated Senators (0-2), 8-2 | Griffith Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Rube Walberg vs Bump Hadley | Second | ½ out |
| Friday, April 19 |
| » Lost to Yankees (2-0), 2-1 | Yankee Stadium (0-1) | 2-1 | |
| » Starters: Jack Quinn vs Waite Hoyt | Third | ½ out |
| Sunday, April 21 |
| » Defeated Yankees (2-1), 7-4 | Yankee Stadium (1-1) | 3-1 | |
| » Starters: Lefty Grove vs Hank Johnson | First | -- |
| Tuesday, April 23 |
| » Lost to Senators (2-3), 4-3 | Shibe Park (0-1) | 3-2 | |
| » Starters: Bump Hadley vs Rube Walberg | Third | ½ out |
| Wednesday, April 24 |
| » Defeated Senators (2-4), 9-4 | Shibe Park (1-1) | 4-2 | |
| » Starters: Firpo Marberry vs George Earnshaw | First | -- |
| Friday, April 26 |
| » Defeated Yankees (3-3), 5-2 | Shibe Park (2-1) | 5-2 | Won 2 |
| » Starters: Herb Pennock vs Jack Quinn | First | -- |
| » Major-league debuts: Liz Funk and Arndt Jorgens (Yankees) |
| Future Athletic Walt Kellner is born in Tucson, AZ. |
| Saturday, April 27 |
| » Lost to Yankees (4-3), 9-7 | Shibe Park (2-2) | 5-3 | |
| » Starters: George Pipgras vs Lefty Grove | Second | 1½ out |
| Sunday, April 28 |
| » Defeated Red Sox (3-5), 7-3 | Braves Field (1-0) | 6-3 | |
| » Starters: Eddie Rommel vs Red Ruffing | Second | 1½ out |
| Monday, April 29 |
| » Defeated Yankees (5-4), 10-1 | Shibe Park (3-2) | 7-3 | Won 2 |
| » Starters: Hank Johnson vs Rube Walberg | First | -- |
| » Major-league debuts: Gordon Rhodes (Yankees) |
| Future Athletic Mickey McDermott is born in Poughkeepsie, NY. |
| Tuesday, April 30 |
| » Lost to Red Sox (4-5), 4-1 | Fenway Park (0-1) | 7-4 | |
| » Starters: George Earnshaw vs Ed Morris | Second | 1½ out |
| Wednesday, May 1 |
| » Defeated Red Sox (4-6), 24-6 | Fenway Park (1-1) | 8-4 | |
| » Starters: Lefty Grove vs Milt Gaston | Second | 1½ out |
| Thursday, May 2 |
| » Defeated Red Sox (4-7), 5-1 | Fenway Park (2-1) | 9-4 | Won 2 |
| » Starters: Lefty Grove vs Jack Russell | Second | 1 out |
| Sunday, May 5 |
| » Defeated Browns (11-5), 2-0 | Sportsman's Park III (1-0) | 10-4 | Won 3 |
| » Starters: Rube Walberg vs Dolly Gray | First | -- |
| Tuesday, May 7 |
| » Lost to White Sox (7-10), 4-2 | Comiskey Park I (0-1) | 10-5 | |
| » Starters: Lefty Grove vs Tommy Thomas | Second | ½ out |
| Future Athletic Dick Williams is born in St. Louis, MO. |
| Wednesday, May 8 |
| » Defeated White Sox (7-11), 5-4 | Comiskey Park I (1-1) | 11-5 | |
| » Starters: Jack Quinn vs Red Faber | Second | ½ out |
| Thursday, May 9 |
| » Defeated White Sox (7-12), 9-2 | Comiskey Park I (2-1) | 12-5 | Won 2 |
| » Starters: George Earnshaw vs Grady Adkins | Second | ½ out |
| Friday, May 10 |
| » Lost to Indians (10-11), 9-0 | League Park II (0-1) | 12-6 | |
| » Starters: Rube Walberg vs Jake Miller | Second | 1½ out |
| Saturday, May 11 |
| » Defeated Indians (10-12), 4-2 | League Park II (1-1) | 13-6 | |
| » Starters: Lefty Grove vs Johnny Miljus | Second | ½ out |
| Monday, May 13 |
| » Lost to Tigers (15-11), 5-3 | Tiger Stadium (0-1) | 13-7 | |
| » Starters: George Earnshaw vs George Uhle | First | -- |
| Tuesday, May 14 |
| » Defeated Tigers (15-12), 10-8 | Tiger Stadium (1-1) | 14-7 | |
| » Starters: Jack Quinn vs Augie Prudhomme | First | -- |
| Wednesday, May 15 |
| » Lost to Tigers (16-12), 6-5 | Tiger Stadium (1-2) | 14-8 | |
| » Starters: Rube Walberg vs Vic Sorrell | First | -- |
| Friday, May 17 |
| » Defeated Senators (8-14), 4-1 | Griffith Stadium (3-0) | 15-8 | |
| » Starters: Lefty Grove vs Bump Hadley | First | -- |
| Saturday, May 18 |
| » Defeated Senators (8-15), 5-4 | Griffith Stadium (4-0) | 16-8 | Won 2 |
| » Starters: George Earnshaw vs Sam Jones | First | -- |
| » Defeated Senators (8-16), 7-5 | Griffith Stadium (5-0) | 17-8 | Won 3 |
| » Starters: Jack Quinn vs Lloyd Brown | First | -- |
| Sunday, May 19 |
| » Defeated Senators (8-17), 7-0 | Griffith Stadium (6-0) | 18-8 | Won 4 |
| » Starters: Rube Walberg vs Bobby Burke | First | -- |
| Monday, May 20 |
| » Defeated Red Sox (8-20), 5-1 | Shibe Park (4-2) | 19-8 | Won 5 |
| » Starters: Red Ruffing vs Eddie Rommel | First | -- |
| Wednesday, May 22 |
| » Defeated Red Sox (8-21), 16-2 | Shibe Park (5-2) | 20-8 | Won 6 |
| » Starters: Ed Morris vs Lefty Grove | First | -- |
| Thursday, May 23 |
| » Defeated Senators (10-18), 9-8 | Shibe Park (6-2) | 21-8 | Won 7 |
| » Starters: Bump Hadley vs George Earnshaw | First | -- |
| » Defeated Senators (10-19), 9-8 | Shibe Park (7-2) | 22-8 | Won 8 |
| » Starters: Lloyd Brown vs Rube Walberg | First | -- |
| Friday, May 24 |
| » Defeated Senators (10-20), 10-3 | Shibe Park (8-2) | 23-8 | Won 9 |
| » Starters: Bump Hadley vs George Earnshaw | First | -- |
| Saturday, May 25 |
| » Defeated Senators (10-21), 5-4 | Shibe Park (9-2) | 24-8 | Won 10 |
| » Starters: Firpo Marberry vs Lefty Grove | First | -- |
| Sunday, May 26 |
| » Defeated Senators (10-22), 4-3 | Griffith Stadium (7-0) | 25-8 | Won 11 |
| » Starters: Jack Quinn vs Garland Braxton | First | -- |
| Tuesday, May 28 |
| » Lost to Red Sox (11-24), 5-4 | Fenway Park (2-2) | 25-9 | |
| » Starters: Rube Walberg vs Milt Gaston | First | -- |
| Wednesday, May 29 |
| » Defeated Red Sox (11-25), 7-1 | Fenway Park (3-2) | 26-9 | |
| » Starters: George Earnshaw vs Danny MacFayden | First | -- |
| Thursday, May 30 |
| » Defeated Red Sox (11-26), 9-2 | Fenway Park (4-2) | 27-9 | Won 2 |
| » Starters: Lefty Grove vs Jack Russell | First | -- |
| » Defeated Red Sox (11-27), 9-3 | Fenway Park (5-2) | 28-9 | Won 3 |
| » Starters: Jack Quinn vs Red Ruffing | First | -- |
| Friday, May 31 |
| » Defeated Tigers (24-21), 9-6 | Shibe Park (10-2) | 29-9 | Won 4 |
| » Starters: Ownie Carroll vs Howard Ehmke | First | -- |
| Saturday, June 1 |
| » Defeated Tigers (24-22), 11-2 | Shibe Park (11-2) | 30-9 | Won 5 |
| » Starters: Earl Whitehill vs George Earnshaw | First | -- |
| Monday, June 3 |
| » Defeated Tigers (24-23), 3-2 | Shibe Park (12-2) | 31-9 | Won 6 |
| » Starters: George Uhle vs Lefty Grove | First | -- |
| Tuesday, June 4 |
| » Lost to Tigers (25-23), 8-4 | Shibe Park (12-3) | 31-10 | |
| » Starters: Vic Sorrell vs Jack Quinn | First | -- |
| Wednesday, June 5 |
| » Defeated Browns (27-18), 5-2 | Shibe Park (13-3) | 32-10 | |
| » Starters: Alvin Crowder vs Rube Walberg | First | -- |
| Thursday, June 6 |
| » Defeated Browns (27-19), 15-4 | Shibe Park (14-3) | 33-10 | Won 2 |
| » Starters: George Blaeholder vs George Earnshaw | First | -- |
| Friday, June 7 |
| » Lost to Browns (28-19), 15-6 | Shibe Park (14-4) | 33-11 | |
| » Starters: Dolly Gray vs Howard Ehmke | First | -- |
| Monday, June 10 |
| » Defeated White Sox (18-33), 3-1 | Shibe Park (15-4) | 34-11 | |
| » Starters: Grady Adkins vs Lefty Grove | First | -- |
| Tuesday, June 11 |
| » Defeated White Sox (18-34), 14-3 | Shibe Park (16-4) | 35-11 | Won 2 |
| » Starters: Ed Walsh vs George Earnshaw | First | -- |
| Wednesday, June 12 |
| » Defeated White Sox (18-35), 7-3 | Shibe Park (17-4) | 36-11 | Won 3 |
| » Starters: Ted Lyons vs Rube Walberg | First | -- |
| Thursday, June 13 |
| » Defeated Indians (25-25), 10-3 | Shibe Park (18-4) | 37-11 | Won 4 |
| » Starters: Jimmy Zinn vs Eddie Rommel | First | -- |
| Friday, June 14 |
| » Defeated Indians (25-26), 9-0 | Shibe Park (19-4) | 38-11 | Won 5 |
| » Starters: Ken Holloway vs Lefty Grove | First | -- |
| Saturday, June 15 |
| » Defeated Indians (25-27), 1-0 | Shibe Park (20-4) | 39-11 | Won 6 |
| » Starters: Willis Hudlin vs George Earnshaw | First | -- |
| Sunday, June 16 |
| » Lost to Indians (26-27), 10-9 | League Park II (1-2) | 39-12 | |
| » Starters: Rube Walberg vs Jake Miller | First | -- |
| Monday, June 17 |
| » Lost to White Sox (21-37), 6-4 | Shibe Park (20-5) | 39-13 | Lost 2 |
| » Starters: Red Faber vs Jack Quinn | First | -- |
| Tuesday, June 18 |
| » Defeated Senators (20-32), 7-6 | Griffith Stadium (8-0) | 40-13 | |
| » Starters: Lefty Grove vs Bump Hadley | First | -- |
| Future Athletic Bill Upton is born in Esther, MO. |
| Thursday, June 20 |
| Future Athletic Wally Burnette is born in Blairs, VA. |
| Friday, June 21 |
| » Defeated Yankees (33-22), 11-1 | Yankee Stadium (2-1) | 41-13 | Won 2 |
| » Starters: Lefty Grove vs Herb Pennock | First | -- |
| » Lost to Yankees (34-22), 8-3 | Yankee Stadium (2-2) | 41-14 | |
| » Starters: George Earnshaw vs Waite Hoyt | First | -- |
| Saturday, June 22 |
| » Defeated Yankees (34-23), 7-3 | Yankee Stadium (3-2) | 42-14 | |
| » Starters: Rube Walberg vs Fred Heimach | First | -- |
| » Lost to Yankees (35-23), 4-3 | Yankee Stadium (3-3) | 42-15 | |
| » Starters: Jack Quinn vs George Pipgras | First | -- |
| Sunday, June 23 |
| » Defeated Yankees (35-24), 7-4 | Yankee Stadium (4-3) | 43-15 | |
| » Starters: Howard Ehmke vs Ed Wells | First | -- |
| Monday, June 24 |
| » Defeated Red Sox (19-44), 5-4 | Shibe Park (21-5) | 44-15 | Won 2 |
| » Starters: Jack Russell vs Eddie Rommel | First | -- |
| Tuesday, June 25 |
| » Defeated Red Sox (19-45), 7-1 | Shibe Park (22-5) | 45-15 | Won 3 |
| » Starters: Danny MacFayden vs Lefty Grove | First | -- |
| » Defeated Red Sox (19-46), 8-2 | Shibe Park (23-5) | 46-15 | Won 4 |
| » Starters: Red Ruffing vs Bill Shores | First | -- |
| Wednesday, June 26 |
| » Defeated Red Sox (19-47), 6-5 | Shibe Park (24-5) | 47-15 | Won 5 |
| » Starters: Milt Gaston vs George Earnshaw | First | -- |
| Thursday, June 27 |
| » Defeated Yankees (36-26), 6-3 | Shibe Park (25-5) | 48-15 | Won 6 |
| » Starters: Waite Hoyt vs Rube Walberg | First | -- |
| Saturday, June 29 |
| » Lost to Yankees (37-26), 7-5 | Shibe Park (25-6) | 48-16 | |
| » Starters: George Pipgras vs Lefty Grove | First | -- |
| Sunday, June 30 |
| » Lost to Senators (26-37), 12-2 | Griffith Stadium (8-1) | 48-17 | Lost 2 |
| » Starters: Jack Quinn vs Firpo Marberry | First | -- |
| Tuesday, July 2 |
| » Defeated Senators (26-38), 7-4 | Shibe Park (26-6) | 49-17 | |
| » Starters: Bump Hadley vs Rube Walberg | First | -- |
| » Defeated Senators (26-39), 4-1 | Shibe Park (27-6) | 50-17 | Won 2 |
| » Starters: Sam Jones vs George Earnshaw | First | -- |
| Wednesday, July 3 |
| » Defeated Senators (26-40), 9-7 | Shibe Park (28-6) | 51-17 | Won 3 |
| » Starters: Myles Thomas vs Eddie Rommel | First | -- |
| Thursday, July 4 |
| » Defeated Red Sox (22-52), 3-1 | Shibe Park (29-6) | 52-17 | Won 4 |
| » Starters: Milt Gaston vs Lefty Grove | First | -- |
| » Defeated Red Sox (22-53), 8-1 | Shibe Park (30-6) | 53-17 | Won 5 |
| » Starters: Jack Russell vs Jack Quinn | First | -- |
| Saturday, July 6 |
| » Lost to White Sox (26-50), 5-4 | Comiskey Park I (2-2) | 53-18 | |
| » Starters: Rube Walberg vs Tommy Thomas | First | -- |
| Sunday, July 7 |
| » Lost to White Sox (27-50), 9-3 | Comiskey Park I (2-3) | 53-19 | Lost 2 |
| » Starters: George Earnshaw vs Ted Lyons | First | -- |
| Monday, July 8 |
| » Defeated White Sox (27-51), 8-2 | Comiskey Park I (3-3) | 54-19 | |
| » Starters: Lefty Grove vs Hal McKain | First | -- |
| Tuesday, July 9 |
| » Lost to White Sox (28-51), 6-4 | Comiskey Park I (3-4) | 54-20 | |
| » Starters: Jack Quinn vs Red Faber | First | -- |
| Wednesday, July 10 |
| » Defeated Browns (45-31), 4-1 | Sportsman's Park III (2-0) | 55-20 | |
| » Starters: Howard Ehmke vs Dolly Gray | First | -- |
| » Lost to Browns (46-31), 7-5 | Sportsman's Park III (2-1) | 55-21 | |
| » Starters: Rube Walberg vs George Blaeholder | First | -- |
| Friday, July 12 |
| » Defeated Browns (46-32), 10-0 | Sportsman's Park III (3-1) | 56-21 | |
| » Starters: Lefty Grove vs Chad Kimsey | First | -- |
| » Defeated Browns (46-33), 8-2 | Sportsman's Park III (4-1) | 57-21 | Won 2 |
| » Starters: George Earnshaw vs Alvin Crowder | First | -- |
| Saturday, July 13 |
| » Lost to Browns (47-33), 3-1 | Sportsman's Park III (4-2) | 57-22 | |
| » Starters: Rube Walberg vs Rip Collins | First | -- |
| » Defeated Browns (47-34), 4-0 | Sportsman's Park III (5-2) | 58-22 | |
| » Starters: Bill Shores vs Dolly Gray | First | -- |
| Sunday, July 14 |
| » Defeated Indians (40-39), 5-3 | League Park II (2-2) | 59-22 | Won 2 |
| » Starters: Carroll Yerkes vs Willis Hudlin | First | -- |
| Monday, July 15 |
| » Lost to Indians (41-39), 8-5 | League Park II (2-3) | 59-23 | |
| » Starters: Howard Ehmke vs Wes Ferrell | First | -- |
| » Defeated Indians (41-40), 4-0 | League Park II (3-3) | 60-23 | |
| » Starters: George Earnshaw vs Johnny Miljus | First | -- |
| Tuesday, July 16 |
| » Defeated Indians (41-41), 7-5 | League Park II (4-3) | 61-23 | Won 2 |
| » Starters: Lefty Grove vs Joe Shaute | First | -- |
| Wednesday, July 17 |
| » Lost to Indians (42-41), 5-2 | League Park II (4-4) | 61-24 | |
| » Starters: Bill Shores vs Jake Miller | First | -- |
| Thursday, July 18 |
| » Defeated Tigers (45-42), 8-4 | Tiger Stadium (2-2) | 62-24 | |
| » Starters: Rube Walberg vs George Uhle | First | -- |
| Friday, July 19 |
| » Defeated Tigers (45-43), 4-2 | Tiger Stadium (3-2) | 63-24 | Won 2 |
| » Starters: George Earnshaw vs Ownie Carroll | First | -- |
| Saturday, July 20 |
| » Defeated Tigers (45-44), 6-2 | Tiger Stadium (4-2) | 64-24 | Won 3 |
| » Starters: Lefty Grove vs Vic Sorrell | First | -- |
| Sunday, July 21 |
| » Defeated Tigers (45-45), 10-7 | Tiger Stadium (5-2) | 65-24 | Won 4 |
| » Starters: Bill Shores vs Skinny Graham | First | -- |
| Tuesday, July 23 |
| » Defeated Indians (45-44), 4-1 | Shibe Park (31-6) | 66-24 | Won 5 |
| » Starters: Willis Hudlin vs Rube Walberg | First | -- |
| » Lost to Indians (46-44), 9-3 | Shibe Park (31-7) | 66-25 | |
| » Starters: Wes Ferrell vs Bill Shores | First | -- |
| Wednesday, July 24 |
| » Defeated Indians (46-45), 5-3 | Shibe Park (32-7) | 67-25 | |
| » Starters: Joe Shaute vs George Earnshaw | First | -- |
| Thursday, July 25 |
| » Defeated Indians (46-46), 21-3 | Shibe Park (33-7) | 68-25 | Won 2 |
| » Starters: Johnny Miljus vs Lefty Grove | First | -- |
| Friday, July 26 |
| » Defeated White Sox (37-58), 3-1 | Shibe Park (34-7) | 69-25 | Won 3 |
| » Starters: Ted Lyons vs Howard Ehmke | First | -- |
| Saturday, July 27 |
| » Defeated White Sox (37-59), 8-1 | Shibe Park (35-7) | 70-25 | Won 4 |
| » Starters: Hal McKain vs Rube Walberg | First | -- |
| Monday, July 29 |
| » Lost to White Sox (38-59), 8-6 | Shibe Park (35-8) | 70-26 | |
| » Starters: Red Faber vs George Earnshaw | First | -- |
| Tuesday, July 30 |
| » Defeated Tigers (47-49), 5-4 | Shibe Park (36-8) | 71-26 | |
| » Starters: George Uhle vs Lefty Grove | First | -- |
| Wednesday, July 31 |
| » Defeated Tigers (47-50), 10-1 | Shibe Park (37-8) | 72-26 | Won 2 |
| » Starters: Ownie Carroll vs Rube Walberg | First | -- |
| Thursday, August 1 |
| » Defeated Tigers (47-51), 7-4 | Shibe Park (38-8) | 73-26 | Won 3 |
| » Starters: Vic Sorrell vs George Earnshaw | First | -- |
| Friday, August 2 |
| » Defeated Tigers (47-52), 11-10 | Shibe Park (39-8) | 74-26 | Won 4 |
| » Starters: Skinny Graham vs Jack Quinn | First | -- |
| Saturday, August 3 |
| » Tied Browns, 8-8 | Shibe Park (39-8) | 74-26 | |
| » Starters: Dolly Gray vs Lefty Grove | First | -- |
| Monday, August 5 |
| » Lost to Browns (54-46), 6-4 | Shibe Park (39-9) | 74-27 | |
| » Starters: Lefty Stewart vs Rube Walberg | First | -- |
| » Defeated Browns (54-47), 8-7 | Shibe Park (40-9) | 75-27 | |
| » Starters: Rip Collins vs Lefty Grove | First | -- |
| Tuesday, August 6 |
| » Lost to Browns (55-47), 8-3 | Shibe Park (40-10) | 75-28 | |
| » Starters: Alvin Crowder vs Bill Shores | First | -- |
| » Defeated Browns (55-48), 11-3 | Shibe Park (41-10) | 76-28 | |
| » Starters: Jack Ogden vs Eddie Rommel | First | -- |
| Wednesday, August 7 |
| » Lost to Yankees (63-37), 13-1 | Shibe Park (41-11) | 76-29 | |
| » Starters: George Pipgras vs Howard Ehmke | First | -- |
| » Defeated Yankees (63-38), 4-2 | Shibe Park (42-11) | 77-29 | |
| » Starters: Roy Sherid vs George Earnshaw | First | -- |
| Thursday, August 8 |
| » Lost to Yankees (64-38), 6-4 | Shibe Park (42-12) | 77-30 | |
| » Starters: Herb Pennock vs Rube Walberg | First | -- |
| Saturday, August 10 |
| » Defeated Tigers (51-55), 6-5 | Tiger Stadium (6-2) | 78-30 | |
| » Starters: Lefty Grove vs Earl Whitehill | First | -- |
| Sunday, August 11 |
| » Lost to Tigers (52-55), 9-8 | Tiger Stadium (6-3) | 78-31 | |
| » Starters: George Earnshaw vs Vic Sorrell | First | -- |
| Monday, August 12 |
| » Defeated Tigers (52-56), 6-0 | Tiger Stadium (7-3) | 79-31 | |
| » Starters: Rube Walberg vs George Uhle | First | -- |
| Tuesday, August 13 |
| » Defeated Tigers (52-57), 4-3 | Tiger Stadium (8-3) | 80-31 | Won 2 |
| » Starters: Jack Quinn vs Vic Sorrell | First | -- |
| Wednesday, August 14 |
| » Defeated Indians (58-52), 5-3 | League Park II (5-4) | 81-31 | Won 3 |
| » Starters: Lefty Grove vs Jake Miller | First | -- |
| Friday, August 16 |
| » Defeated Indians (58-53), 6-5 | League Park II (6-4) | 82-31 | Won 4 |
| » Starters: George Earnshaw vs Joe Shaute | First | -- |
| Saturday, August 17 |
| » Lost to Indians (59-53), 2-1 | League Park II (6-5) | 82-32 | |
| » Starters: Rube Walberg vs Wes Ferrell | First | -- |
| Sunday, August 18 |
| » Lost to Browns (59-56), 4-3 | Sportsman's Park III (5-3) | 82-33 | Lost 2 |
| » Starters: Lefty Grove vs Dolly Gray | First | -- |
| Monday, August 19 |
| » Defeated Browns (59-57), 8-2 | Sportsman's Park III (6-3) | 83-33 | |
| » Starters: Bill Shores vs George Blaeholder | First | -- |
| Tuesday, August 20 |
| » Lost to Browns (60-57), 2-1 | Sportsman's Park III (6-4) | 83-34 | |
| » Starters: George Earnshaw vs Alvin Crowder | First | -- |
| Wednesday, August 21 |
| » Lost to Browns (61-57), 7-5 | Sportsman's Park III (6-5) | 83-35 | Lost 2 |
| » Starters: Rube Walberg vs Rip Collins | First | -- |
| Thursday, August 22 |
| » Lost to White Sox (47-72), 4-3 | Comiskey Park I (3-5) | 83-36 | Lost 3 |
| » Starters: Lefty Grove vs Ted Lyons | First | -- |
| Friday, August 23 |
| » Lost to White Sox (48-72), 3-1 | Comiskey Park I (3-6) | 83-37 | Lost 4 |
| » Starters: Jack Quinn vs Hal McKain | First | -- |
| Saturday, August 24 |
| » Defeated White Sox (48-73), 5-2 | Comiskey Park I (4-6) | 84-37 | |
| » Starters: Rube Walberg vs Red Faber | First | -- |
| Sunday, August 25 |
| » Lost to White Sox (49-73), 3-0 | Comiskey Park I (4-7) | 84-38 | |
| » Starters: Bill Shores vs Tommy Thomas | First | -- |
| Tuesday, August 27 |
| » Lost to Yankees (70-49), 2-0 | Yankee Stadium (4-4) | 84-39 | Lost 2 |
| » Starters: George Earnshaw vs George Pipgras | First | -- |
| Wednesday, August 28 |
| » Defeated Yankees (70-50), 9-7 | Yankee Stadium (5-4) | 85-39 | |
| » Starters: Rube Walberg vs Roy Sherid | First | -- |
| Thursday, August 29 |
| » Defeated Red Sox (43-81), 7-6 | Shibe Park (43-12) | 86-39 | Won 2 |
| » Starters: Ed Morris vs Bill Shores | First | -- |
| Friday, August 30 |
| » Lost to Red Sox (44-81), 4-2 | Shibe Park (43-13) | 86-40 | |
| » Starters: Jack Russell vs George Earnshaw | First | -- |
| Saturday, August 31 |
| » Defeated Red Sox (44-82), 9-4 | Shibe Park (44-13) | 87-40 | |
| » Starters: Red Ruffing vs Lefty Grove | First | -- |
| Sunday, September 1 |
| » Lost to Senators (57-68), 12-3 | Griffith Stadium (8-2) | 87-41 | |
| » Starters: Bill Shores vs Sam Jones | First | -- |
| Monday, September 2 |
| » Defeated Yankees (74-52), 10-3 | Shibe Park (45-13) | 88-41 | |
| » Starters: George Pipgras vs Jack Quinn | First | -- |
| » Defeated Yankees (74-53), 6-5 | Shibe Park (46-13) | 89-41 | Won 2 |
| » Starters: Herb Pennock vs Rube Walberg | First | -- |
| Tuesday, September 3 |
| » Defeated Yankees (74-54), 10-2 | Shibe Park (47-13) | 90-41 | Won 3 |
| » Starters: George Pipgras vs George Earnshaw | First | -- |
| Saturday, September 7 |
| » Defeated Indians (69-60), 5-1 | Shibe Park (48-13) | 91-41 | Won 4 |
| » Starters: Jake Miller vs Lefty Grove | First | -- |
| » Lost to Indians (70-60), 4-0 | Shibe Park (48-14) | 91-42 | |
| » Starters: Willis Hudlin vs Rube Walberg | First | -- |
| Tuesday, September 10 |
| » Defeated Indians (70-61), 6-5 | Shibe Park (49-14) | 92-42 | |
| » Starters: Wes Ferrell vs George Earnshaw | First | -- |
| Wednesday, September 11 |
| » Defeated White Sox (53-79), 7-4 | Shibe Park (50-14) | 93-42 | Won 2 |
| » Starters: Ted Lyons vs Lefty Grove | First | -- |
| Thursday, September 12 |
| » Defeated White Sox (53-80), 4-3 | Shibe Park (51-14) | 94-42 | Won 3 |
| » Starters: Tommy Thomas vs Rube Walberg | First | -- |
| Friday, September 13 |
| » Defeated White Sox (53-81), 5-2 | Shibe Park (52-14) | 95-42 | Won 4 |
| » Starters: Ed Walsh vs Howard Ehmke | First | -- |
| Saturday, September 14 |
| » Defeated White Sox (53-82), 5-0 | Shibe Park (53-14) | 96-42 | Won 5 |
| » Starters: Red Faber vs George Earnshaw | First | -- |
| Monday, September 16 |
| » Lost to Browns (72-66), 3-2 | Shibe Park (53-15) | 96-43 | |
| » Starters: Alvin Crowder vs Jack Quinn | First | -- |
| Wednesday, September 18 |
| » Lost to Browns (73-66), 6-2 | Shibe Park (53-16) | 96-44 | Lost 2 |
| » Starters: Dolly Gray vs Lefty Grove | First | -- |
| » Defeated Browns (73-67), 4-3 | Shibe Park (54-16) | 97-44 | |
| » Starters: Rip Collins vs George Earnshaw | First | -- |
| » Major-league debuts: Doc Cramer (Athletics) |
| Thursday, September 19 |
| » Defeated Tigers (65-78), 5-4 | Shibe Park (55-16) | 98-44 | Won 2 |
| » Starters: Art Herring vs Rube Walberg | First | -- |
| Friday, September 20 |
| » Defeated Tigers (65-79), 2-1 | Shibe Park (56-16) | 99-44 | Won 3 |
| » Starters: Whit Wyatt vs Bill Shores | First | -- |
| Saturday, September 21 |
| » Defeated Tigers (65-80), 10-7 | Shibe Park (57-16) | 100-44 | Won 4 |
| » Starters: George Uhle vs Bill Breckinridge | First | -- |
| Sunday, September 22 |
| » Lost to Senators (68-77), 7-6 | Griffith Stadium (8-3) | 100-45 | |
| » Starters: Lefty Grove vs Bump Hadley | First | -- |
| Former Athletic Elton Chamberlain dies in Baltimore, MD at the age of 62. |
| Thursday, September 26 |
| » Defeated Red Sox (55-95), 5-3 | Fenway Park (6-2) | 101-45 | |
| » Starters: George Earnshaw vs Jack Russell | First | -- |
| Saturday, September 28 |
| » Defeated Red Sox (55-96), 6-3 | Fenway Park (7-2) | 102-45 | Won 2 |
| » Starters: Bill Shores vs Danny MacFayden | First | -- |
| Sunday, September 29 |
| » Lost to Red Sox (56-96), 10-0 | Braves Field (1-1) | 102-46 | |
| » Starters: Lefty Grove vs Red Ruffing | First | -- |
| Saturday, October 5 |
| » Defeated Yankees (88-65), 8-4 | Yankee Stadium (6-4) | 103-46 | |
| » Starters: Lefty Grove vs Roy Sherid | First | -- |
| Sunday, October 6 |
| » Defeated Yankees (88-66), 5-2 | Yankee Stadium (7-4) | 104-46 | Won 2 |
| » Starters: Bill Shores vs Gordon Rhodes | First | -- |
| Friday, October 11 |
| Future Athletic Skeeter Kell is born in Swifton, AR. |
Game information provided by Retrosheet (www.retrosheet.org) |
