| Monday, January 16 |
| Former Indian Claude Rossman dies in Poughkeepsie, NY at the age of 47. |
| Monday, January 23 |
| Future Indian Chico Carrasquel is born in Caracas, Venezuela. |
| Saturday, January 28 |
| Former Indian Jake Thielman dies in Minneapolis, MN at the age of 49. |
| Tuesday, February 7 |
| Future Indian Al Smith is born in Kirkwood, MO. |
| Friday, February 24 |
| Future Indian Bubba Phillips is born in West Point, MS. |
| Friday, March 23 |
| Future Indian Jim Lemon is born in Covington, VA. |
| Tuesday, April 10 |
| » Major-league debuts: Doug Taitt (Red Sox) |
| Wednesday, April 11 |
| » Defeated White Sox (0-1), 8-2 | Comiskey Park I (1-0) | 1-0 | |
| » Starters: George Uhle vs Ted Lyons | First | -- |
| » Major-league debuts: Bill Cissell and Buck Redfern (White Sox) Ed Morgan (Indians) |
| Thursday, April 12 |
| » Defeated White Sox (0-2), 2-1 | Comiskey Park I (2-0) | 2-0 | Won 2 |
| » Starters: Joe Shaute vs Tommy Thomas | First | -- |
| Friday, April 13 |
| » Tied White Sox, 1-1 | Comiskey Park I (2-0) | 2-0 | |
| » Starters: Jake Miller vs Grady Adkins | Second | ½ out |
| » Major-league debuts: Grady Adkins (White Sox) |
| Saturday, April 14 |
| » Defeated Tigers (0-4), 8-6 | Tiger Stadium (1-0) | 3-0 | Won 3 |
| » Starters: Willis Hudlin vs Lil Stoner | First | -- |
| Sunday, April 15 |
| » Lost to Tigers (1-4), 8-2 | Tiger Stadium (1-1) | 3-1 | |
| » Starters: Garland Buckeye vs Josh Billings | Third | 1 out |
| Monday, April 16 |
| » Defeated Tigers (1-5), 5-4 | Tiger Stadium (2-1) | 4-1 | |
| » Starters: George Uhle vs Earl Whitehill | Second | 1 out |
| Tuesday, April 17 |
| » Defeated Tigers (1-6), 6-4 | Tiger Stadium (3-1) | 5-1 | Won 2 |
| » Starters: George Grant vs Sam Gibson | Second | 1½ out |
| Wednesday, April 18 |
| » Defeated White Sox (2-4), 7-1 | League Park II (1-0) | 6-1 | Won 3 |
| » Starters: Grady Adkins vs Joe Shaute | Second | 1½ out |
| Thursday, April 19 |
| » Defeated White Sox (2-5), 9-2 | League Park II (2-0) | 7-1 | Won 4 |
| » Starters: Charlie Barnabe vs Willis Hudlin | First | -- |
| Friday, April 20 |
| » Lost to White Sox (3-5), 11-1 | League Park II (2-1) | 7-2 | |
| » Starters: Tommy Thomas vs Jake Miller | First | -- |
| Sunday, April 22 |
| » Defeated Browns (5-6), 2-1 | Sportsman's Park III (1-0) | 8-2 | |
| » Starters: George Uhle vs George Blaeholder | First | -- |
| Monday, April 23 |
| » Lost to Browns (6-6), 4-2 | Sportsman's Park III (1-1) | 8-3 | |
| » Starters: Joe Shaute vs Dolly Gray | First | -- |
| Tuesday, April 24 |
| » Lost to Browns (7-6), 6-2 | Sportsman's Park III (1-2) | 8-4 | Lost 2 |
| » Starters: Willis Hudlin vs Jack Ogden | First | -- |
| » Major-league debuts: Mel Harder (Indians) |
| Wednesday, April 25 |
| » Defeated Browns (7-7), 7-3 | Sportsman's Park III (2-2) | 9-4 | |
| » Starters: Garland Buckeye vs Lefty Stewart | Second | 1½ out |
| Thursday, April 26 |
| » Defeated Tigers (6-10), 6-1 | League Park II (3-1) | 10-4 | Won 2 |
| » Starters: Vic Sorrell vs George Grant | Second | 1½ out |
| Friday, April 27 |
| » Defeated Tigers (6-11), 10-6 | League Park II (4-1) | 11-4 | Won 3 |
| » Starters: Josh Billings vs George Uhle | First | -- |
| Saturday, April 28 |
| » Defeated Tigers (6-12), 6-3 | League Park II (5-1) | 12-4 | Won 4 |
| » Starters: Ownie Carroll vs Joe Shaute | First | -- |
| Sunday, April 29 |
| » Lost to Tigers (7-12), 7-6 | League Park II (5-2) | 12-5 | |
| » Starters: Sam Gibson vs Jake Miller | Second | 2½ out |
| Monday, April 30 |
| » Lost to Browns (11-8), 10-3 | League Park II (5-3) | 12-6 | Lost 2 |
| » Starters: George Blaeholder vs Garland Buckeye | Second | 2½ out |
| Tuesday, May 1 |
| » Defeated Browns (11-9), 4-3 | League Park II (6-3) | 13-6 | |
| » Starters: Boom-Boom Beck vs George Grant | Second | 2½ out |
| Wednesday, May 2 |
| » Lost to Browns (12-9), 7-0 | League Park II (6-4) | 13-7 | |
| » Starters: Dolly Gray vs George Uhle | Second | 2½ out |
| Friday, May 4 |
| » Lost to Red Sox (6-11), 3-2 | Fenway Park (0-1) | 13-8 | Lost 2 |
| » Starters: Willis Hudlin vs Danny MacFayden | Second | 2½ out |
| Saturday, May 5 |
| » Defeated Red Sox (6-12), 5-4 | Fenway Park (1-1) | 14-8 | |
| » Starters: Joe Shaute vs Red Ruffing | Third | 2½ out |
| Monday, May 7 |
| » Defeated Red Sox (6-14), 4-2 | Fenway Park (2-1) | 15-8 | Won 2 |
| » Starters: Jake Miller vs Slim Harriss | Third | 2 out |
| Tuesday, May 8 |
| » Defeated Yankees (15-5), 3-0 | Yankee Stadium (1-0) | 16-8 | Won 3 |
| » Starters: George Uhle vs Herb Pennock | Third | 2 out |
| Thursday, May 10 |
| » Lost to Yankees (16-5), 4-2 | Yankee Stadium (1-1) | 16-9 | |
| » Starters: Willis Hudlin vs George Pipgras | Third | 2 out |
| Friday, May 11 |
| » Lost to Yankees (17-5), 7-6 | Yankee Stadium (1-2) | 16-10 | Lost 2 |
| » Starters: Joe Shaute vs Waite Hoyt | Third | 3 out |
| Saturday, May 12 |
| » Defeated Athletics (13-6), 3-1 | Shibe Park (1-0) | 17-10 | |
| » Starters: Jake Miller vs Ossie Orwoll | Third | 3 out |
| Sunday, May 13 |
| » Defeated Athletics (13-7), 2-0 | League Park II (7-4) | 18-10 | Won 2 |
| » Starters: Eddie Rommel vs George Uhle | Third | 3 out |
| Monday, May 14 |
| » Lost to Athletics (14-7), 6-3 | Shibe Park (1-1) | 18-11 | |
| » Starters: Willis Hudlin vs Lefty Grove | Third | 4 out |
| Tuesday, May 15 |
| » Lost to Athletics (15-7), 5-0 | Shibe Park (1-2) | 18-12 | Lost 2 |
| » Starters: Joe Shaute vs Jack Quinn | Third | 5 out |
| Wednesday, May 16 |
| » Lost to Athletics (16-7), 15-2 | Shibe Park (1-3) | 18-13 | Lost 3 |
| » Starters: Jake Miller vs Rube Walberg | Third | 5½ out |
| Future Indian Billy Martin is born in Berkeley, CA. |
| Thursday, May 17 |
| » Defeated Senators (11-16), 8-3 | Griffith Stadium (1-0) | 19-13 | |
| » Starters: George Uhle vs Sam Jones | Third | 5½ out |
| Saturday, May 19 |
| » Defeated Senators (11-17), 9-7 | Griffith Stadium (2-0) | 20-13 | Won 2 |
| » Starters: Joe Shaute vs Milt Gaston | Third | 5 out |
| Sunday, May 20 |
| » Defeated Senators (11-18), 4-3 | Griffith Stadium (3-0) | 21-13 | Won 3 |
| » Starters: Willis Hudlin vs Hod Lisenbee | Third | 5 out |
| Tuesday, May 22 |
| » Lost to White Sox (12-22), 4-3 | Comiskey Park I (2-1) | 21-14 | |
| » Starters: George Uhle vs Ted Blankenship | Third | 6 out |
| Wednesday, May 23 |
| » Lost to White Sox (13-22), 4-3 | Comiskey Park I (2-2) | 21-15 | Lost 2 |
| » Starters: Jake Miller vs Grady Adkins | Third | 7 out |
| Thursday, May 24 |
| » Lost to Browns (16-20), 12-9 | League Park II (7-5) | 21-16 | Lost 3 |
| » Starters: Dolly Gray vs Willis Hudlin | Third | 7½ out |
| Friday, May 25 |
| » Defeated Browns (16-21), 8-4 | League Park II (8-5) | 22-16 | |
| » Starters: Alvin Crowder vs Garland Buckeye | Third | 8 out |
| Saturday, May 26 |
| » Defeated Browns (16-22), 7-4 | League Park II (9-5) | 23-16 | Won 2 |
| » Starters: Jack Ogden vs George Grant | Third | 8 out |
| Sunday, May 27 |
| » Lost to Browns (17-22), 10-8 | League Park II (9-6) | 23-17 | |
| » Starters: George Blaeholder vs George Uhle | Third | 8½ out |
| Wednesday, May 30 |
| » Lost to Tigers (16-26), 4-3 | League Park II (9-7) | 23-18 | Lost 2 |
| » Starters: Earl Whitehill vs Jake Miller | Third | 10½ out |
| » Lost to Tigers (17-26), 6-5 | League Park II (9-8) | 23-19 | Lost 3 |
| » Starters: Ken Holloway vs Willis Hudlin | Third | 10½ out |
| Thursday, May 31 |
| » Lost to Tigers (18-26), 9-4 | League Park II (9-9) | 23-20 | Lost 4 |
| » Starters: Sam Gibson vs Joe Shaute | Third | 11½ out |
| Friday, June 1 |
| » Lost to Tigers (19-26), 5-4 | League Park II (9-10) | 23-21 | Lost 5 |
| » Starters: Josh Billings vs George Uhle | Third | 12 out |
| Saturday, June 2 |
| » Defeated Red Sox (15-23), 6-0 | League Park II (10-10) | 24-21 | |
| » Starters: Ed Morris vs George Grant | Third | 12 out |
| Sunday, June 3 |
| » Lost to Red Sox (16-23), 4-3 | League Park II (10-11) | 24-22 | |
| » Starters: Red Ruffing vs Willis Hudlin | Third | 13 out |
| Wednesday, June 6 |
| » Lost to Yankees (37-8), 8-3 | League Park II (10-12) | 24-23 | Lost 2 |
| » Starters: Herb Pennock vs George Uhle | Third | 14 out |
| Thursday, June 7 |
| » Lost to Yankees (38-8), 8-2 | League Park II (10-13) | 24-24 | Lost 3 |
| » Starters: George Pipgras vs Joe Shaute | Third | 15 out |
| Saturday, June 9 |
| » Lost to Yankees (39-8), 7-3 | League Park II (10-14) | 24-25 | Lost 4 |
| » Starters: Waite Hoyt vs Jake Miller | Fourth | 16 out |
| Sunday, June 10 |
| » Lost to Senators (18-27), 6-5 | League Park II (10-15) | 24-26 | Lost 5 |
| » Starters: Garland Braxton vs Willis Hudlin | Fourth | 16 out |
| Monday, June 11 |
| » Lost to Senators (19-27), 7-6 | League Park II (10-16) | 24-27 | Lost 6 |
| » Starters: Bump Hadley vs George Grant | Fourth | 16 out |
| Tuesday, June 12 |
| » Lost to Senators (20-27), 3-2 | League Park II (10-17) | 24-28 | Lost 7 |
| » Starters: Sam Jones vs Dutch Levsen | Fourth | 17 out |
| Wednesday, June 13 |
| » Defeated Senators (20-28), 8-7 | League Park II (11-17) | 25-28 | |
| » Starters: Hod Lisenbee vs Joe Shaute | Fourth | 17 out |
| Thursday, June 14 |
| » Lost to Athletics (32-19), 9-8 | League Park II (11-18) | 25-29 | |
| » Starters: Rube Walberg vs Willis Hudlin | Fourth | 18 out |
| Friday, June 15 |
| » Lost to Athletics (33-19), 12-5 | League Park II (11-19) | 25-30 | Lost 2 |
| » Starters: Lefty Grove vs Garland Buckeye | Fourth | 18 out |
| Saturday, June 16 |
| » Defeated Athletics (33-20), 9-2 | League Park II (12-19) | 26-30 | |
| » Starters: George Earnshaw vs George Uhle | Fourth | 17 out |
| Sunday, June 17 |
| » Lost to Athletics (34-20), 8-7 | League Park II (12-20) | 26-31 | |
| » Starters: Howard Ehmke vs Joe Shaute | Fourth | 18 out |
| Wednesday, June 20 |
| » Lost to White Sox (21-35), 6-4 | League Park II (12-21) | 26-32 | Lost 2 |
| » Starters: Ted Lyons vs Dutch Levsen | Fourth | 18 out |
| » Defeated White Sox (21-36), 4-3 | League Park II (13-21) | 27-32 | |
| » Starters: Red Faber vs George Grant | Fourth | 18 out |
| Thursday, June 21 |
| » Defeated White Sox (21-37), 4-2 | League Park II (14-21) | 28-32 | Won 2 |
| » Starters: Tommy Thomas vs Jake Miller | Fourth | 18½ out |
| » Lost to White Sox (22-37), 4-3 | League Park II (14-22) | 28-33 | |
| » Starters: Grady Adkins vs Joe Shaute | Fourth | 18½ out |
| Friday, June 22 |
| » Lost to White Sox (23-37), 7-4 | League Park II (14-23) | 28-34 | Lost 2 |
| » Starters: Ted Blankenship vs George Uhle | Fifth | 19 out |
| Saturday, June 23 |
| » Lost to Browns (34-29), 10-3 | Sportsman's Park III (2-3) | 28-35 | Lost 3 |
| » Starters: Garland Buckeye vs Dolly Gray | Fourth | 18½ out |
| Sunday, June 24 |
| » Defeated Browns (34-30), 4-2 | Sportsman's Park III (3-3) | 29-35 | |
| » Starters: George Grant vs George Blaeholder | Fourth | 18½ out |
| Monday, June 25 |
| » Defeated Browns (34-31), 7-4 | Sportsman's Park III (4-3) | 30-35 | Won 2 |
| » Starters: Willis Hudlin vs Dick Coffman | Fifth | 18 out |
| Tuesday, June 26 |
| » Lost to Browns (35-31), 6-3 | Sportsman's Park III (4-4) | 30-36 | |
| » Starters: Joe Shaute vs Alvin Crowder | Fifth | 18½ out |
| Thursday, June 28 |
| » Lost to White Sox (27-38), 3-2 | Comiskey Park I (2-3) | 30-37 | Lost 2 |
| » Starters: George Uhle vs Ted Blankenship | Fifth | 20 out |
| Friday, June 29 |
| » Defeated White Sox (27-39), 9-8 | Comiskey Park I (3-3) | 31-37 | |
| » Starters: George Grant vs Red Faber | Fifth | 19 out |
| Saturday, June 30 |
| » Defeated White Sox (27-40), 8-1 | Comiskey Park I (4-3) | 32-37 | Won 2 |
| » Starters: Joe Shaute vs Ted Lyons | Fourth | 20 out |
| » Lost to White Sox (28-40), 6-2 | Comiskey Park I (4-4) | 32-38 | |
| » Starters: Dutch Levsen vs Tommy Thomas | Fourth | 20 out |
| Sunday, July 1 |
| » Defeated White Sox (28-41), 5-2 | Comiskey Park I (5-4) | 33-38 | |
| » Starters: Willis Hudlin vs Grady Adkins | Fourth | 20½ out |
| Monday, July 2 |
| » Lost to Tigers (28-43), 7-3 | Tiger Stadium (3-2) | 33-39 | |
| » Starters: George Uhle vs Earl Whitehill | Fourth | 20½ out |
| Tuesday, July 3 |
| » Defeated Tigers (28-44), 6-5 | Tiger Stadium (4-2) | 34-39 | |
| » Starters: George Grant vs Ken Holloway | Fourth | 20½ out |
| Wednesday, July 4 |
| » Lost to Tigers (29-44), 10-5 | Tiger Stadium (4-3) | 34-40 | |
| » Starters: Joe Shaute vs Ownie Carroll | Fourth | 20½ out |
| » Defeated Tigers (29-45), 4-3 | Tiger Stadium (5-3) | 35-40 | |
| » Starters: Jake Miller vs Josh Billings | Fourth | 20½ out |
| Thursday, July 5 |
| Future Indian Jim Baxes is born in San Francisco, CA. |
| Saturday, July 7 |
| » Defeated Athletics (44-32), 2-1 | Shibe Park (2-3) | 36-40 | Won 2 |
| » Starters: Willis Hudlin vs Rube Walberg | Fourth | 21½ out |
| » Lost to Athletics (45-32), 6-2 | Shibe Park (2-4) | 36-41 | |
| » Starters: George Uhle vs Eddie Rommel | Fourth | 21½ out |
| Monday, July 9 |
| » Lost to Athletics (46-32), 14-4 | Shibe Park (2-5) | 36-42 | Lost 2 |
| » Starters: George Grant vs Jack Quinn | Fourth | 21 out |
| Tuesday, July 10 |
| » Lost to Senators (35-44), 9-5 | Griffith Stadium (3-1) | 36-43 | Lost 3 |
| » Starters: Joe Shaute vs Lloyd Brown | Fourth | 22 out |
| » Lost to Senators (36-44), 9-0 | Griffith Stadium (3-2) | 36-44 | Lost 4 |
| » Starters: Jake Miller vs Milt Gaston | Fourth | 22 out |
| Wednesday, July 11 |
| » Defeated Senators (36-45), 2-1 | Griffith Stadium (4-2) | 37-44 | |
| » Starters: Willis Hudlin vs Bump Hadley | Fourth | 21½ out |
| Thursday, July 12 |
| » Defeated Senators (36-46), 2-1 | Griffith Stadium (5-2) | 38-44 | Won 2 |
| » Starters: George Uhle vs Garland Braxton | Fourth | 20½ out |
| Sunday, July 15 |
| » Lost to Yankees (59-23), 3-0 | Yankee Stadium (1-3) | 38-45 | |
| » Starters: Joe Shaute vs Herb Pennock | Fifth | 22½ out |
| » Lost to Yankees (60-23), 6-4 | Yankee Stadium (1-4) | 38-46 | Lost 2 |
| » Starters: George Grant vs Myles Thomas | Fifth | 22½ out |
| Monday, July 16 |
| » Lost to Yankees (61-23), 7-3 | Yankee Stadium (1-5) | 38-47 | Lost 3 |
| » Starters: Bill Bayne vs George Pipgras | Fifth | 24½ out |
| » Lost to Yankees (62-23), 6-2 | Yankee Stadium (1-6) | 38-48 | Lost 4 |
| » Starters: Willis Hudlin vs Hank Johnson | Fifth | 24½ out |
| Tuesday, July 17 |
| » Lost to Yankees (63-23), 4-2 | Yankee Stadium (1-7) | 38-49 | Lost 5 |
| » Starters: George Uhle vs Al Shealy | Fifth | 25½ out |
| Wednesday, July 18 |
| » Defeated Red Sox (34-50), 6-5 | Fenway Park (3-1) | 39-49 | |
| » Starters: Jake Miller vs Jack Russell | Fifth | 25½ out |
| Future Indian Billy Harrell is born in Norristown, PA. Former Indian Ed Killian dies in Detroit, MI at the age of 52 |
| Thursday, July 19 |
| » Lost to Red Sox (35-50), 3-2 | Fenway Park (3-2) | 39-50 | |
| » Starters: Joe Shaute vs Ed Morris | Fifth | 26½ out |
| Saturday, July 21 |
| » Lost to Red Sox (36-50), 5-2 | Fenway Park (3-3) | 39-51 | Lost 2 |
| » Starters: George Grant vs Red Ruffing | Fifth | 27 out |
| » Defeated Red Sox (36-51), 5-1 | Fenway Park (4-3) | 40-51 | |
| » Starters: Bill Bayne vs Slim Harriss | Fifth | 27 out |
| Sunday, July 22 |
| » Lost to Browns (48-46), 8-5 | League Park II (14-24) | 40-52 | |
| » Starters: Dolly Gray vs Willis Hudlin | Sixth | 27 out |
| Future Indian Stu Locklin is born in Appleton, WI. |
| Monday, July 23 |
| » Lost to Browns (49-46), 10-0 | League Park II (14-25) | 40-53 | Lost 2 |
| » Starters: George Blaeholder vs George Uhle | Sixth | 27 out |
| Wednesday, July 25 |
| » Defeated Red Sox (37-53), 10-2 | League Park II (15-25) | 41-53 | |
| » Starters: Ed Morris vs Jake Miller | Fifth | 25½ out |
| » Defeated Red Sox (37-54), 15-5 | League Park II (16-25) | 42-53 | Won 2 |
| » Starters: Pat Simmons vs Joe Shaute | Fifth | 25½ out |
| Thursday, July 26 |
| » Defeated Red Sox (37-55), 4-2 | League Park II (17-25) | 43-53 | Won 3 |
| » Starters: Red Ruffing vs Bill Bayne | Fourth | 24½ out |
| » Defeated Red Sox (37-56), 4-3 | League Park II (18-25) | 44-53 | Won 4 |
| » Starters: Slim Harriss vs George Grant | Fourth | 24½ out |
| Saturday, July 28 |
| » Lost to Yankees (69-28), 6-2 | League Park II (18-26) | 44-54 | |
| » Starters: Herb Pennock vs George Uhle | Fourth | 24½ out |
| » Defeated Yankees (69-29), 9-4 | League Park II (19-26) | 45-54 | |
| » Starters: Al Shealy vs Willis Hudlin | Fourth | 24½ out |
| Sunday, July 29 |
| » Defeated Yankees (69-30), 24-6 | League Park II (20-26) | 46-54 | Won 2 |
| » Starters: George Pipgras vs Joe Shaute | Fourth | 23½ out |
| Monday, July 30 |
| » Defeated Yankees (69-31), 4-2 | League Park II (21-26) | 47-54 | Won 3 |
| » Starters: George Pipgras vs Jake Miller | Fourth | 22½ out |
| Tuesday, July 31 |
| » Lost to Yankees (70-31), 12-9 | League Park II (21-27) | 47-55 | |
| » Starters: Waite Hoyt vs Bill Bayne | Fourth | 23½ out |
| Wednesday, August 1 |
| » Lost to Athletics (65-36), 6-4 | League Park II (21-28) | 47-56 | Lost 2 |
| » Starters: Howard Ehmke vs Willis Hudlin | Fourth | 24½ out |
| Thursday, August 2 |
| » Lost to Athletics (66-36), 6-0 | League Park II (21-29) | 47-57 | Lost 3 |
| » Starters: George Earnshaw vs George Uhle | Fifth | 24½ out |
| Friday, August 3 |
| » Defeated Athletics (66-37), 9-5 | League Park II (22-29) | 48-57 | |
| » Starters: Rube Walberg vs Joe Shaute | Fourth | 23½ out |
| Saturday, August 4 |
| » Defeated Senators (47-60), 2-1 | League Park II (23-29) | 49-57 | Won 2 |
| » Starters: Garland Braxton vs George Grant | Fourth | 23½ out |
| Monday, August 6 |
| » Defeated Senators (47-61), 7-4 | League Park II (24-29) | 50-57 | Won 3 |
| » Starters: Milt Gaston vs Jake Miller | Fourth | 22½ out |
| » Lost to Senators (48-61), 11-2 | League Park II (24-30) | 50-58 | |
| » Starters: Bump Hadley vs Johnny Miljus | Fourth | 22½ out |
| Tuesday, August 7 |
| » Lost to Senators (49-61), 8-0 | League Park II (24-31) | 50-59 | Lost 2 |
| » Starters: Sam Jones vs George Uhle | Fourth | 23½ out |
| Friday, August 10 |
| » Lost to Tigers (47-60), 8-7 | League Park II (24-32) | 50-60 | Lost 3 |
| » Starters: Ken Holloway vs Willis Hudlin | Fifth | 25 out |
| Saturday, August 11 |
| » Lost to Tigers (48-60), 10-4 | League Park II (24-33) | 50-61 | Lost 4 |
| » Starters: Vic Sorrell vs Joe Shaute | Fifth | 26 out |
| Sunday, August 12 |
| » Defeated Tigers (48-61), 3-2 | League Park II (25-33) | 51-61 | |
| » Starters: Earl Whitehill vs Jake Miller | Fourth | 26 out |
| Monday, August 13 |
| » Lost to Red Sox (41-70), 6-2 | Fenway Park (4-4) | 51-62 | |
| » Starters: George Grant vs Ed Morris | Fifth | 26½ out |
| Tuesday, August 14 |
| » Defeated Red Sox (41-71), 2-1 | Fenway Park (5-4) | 52-62 | |
| » Starters: George Uhle vs Red Ruffing | Fifth | 25½ out |
| Wednesday, August 15 |
| » Defeated Red Sox (41-72), 7-0 | Fenway Park (6-4) | 53-62 | Won 2 |
| » Starters: Joe Shaute vs Marty Griffin | Fifth | 24½ out |
| Thursday, August 16 |
| » Defeated Red Sox (41-73), 10-8 | Fenway Park (7-4) | 54-62 | Won 3 |
| » Starters: Bill Bayne vs Danny MacFayden | Fourth | 24½ out |
| Saturday, August 18 |
| » Lost to Yankees (79-37), 8-5 | Yankee Stadium (1-8) | 54-63 | |
| » Starters: Jake Miller vs George Pipgras | Fourth | 25½ out |
| Sunday, August 19 |
| » Defeated Yankees (79-38), 3-2 | Yankee Stadium (2-8) | 55-63 | |
| » Starters: Joe Shaute vs Fred Heimach | Fourth | 25½ out |
| » Lost to Yankees (80-38), 10-2 | Yankee Stadium (2-9) | 55-64 | |
| » Starters: George Uhle vs Hank Johnson | Fourth | 25½ out |
| Monday, August 20 |
| » Major-league debuts: Art Shires (White Sox) |
| Tuesday, August 21 |
| » Lost to Athletics (75-43), 12-4 | Shibe Park (2-6) | 55-65 | Lost 2 |
| » Starters: Bill Bayne vs Jack Quinn | Fifth | 26½ out |
| Wednesday, August 22 |
| » Lost to Athletics (76-43), 6-5 | Shibe Park (2-7) | 55-66 | Lost 3 |
| » Starters: George Uhle vs George Earnshaw | Fifth | 27 out |
| Thursday, August 23 |
| » Lost to Athletics (77-43), 3-1 | Shibe Park (2-8) | 55-67 | Lost 4 |
| » Starters: Jake Miller vs Lefty Grove | Sixth | 27½ out |
| Friday, August 24 |
| » Lost to Athletics (78-43), 1-0 | Shibe Park (2-9) | 55-68 | Lost 5 |
| » Starters: Joe Shaute vs Rube Walberg | Sixth | 27 out |
| Saturday, August 25 |
| » Defeated Senators (55-68), 10-9 | Griffith Stadium (6-2) | 56-68 | |
| » Starters: Willis Hudlin vs Milt Gaston | Sixth | 27 out |
| » Lost to Senators (56-68), 4-3 | Griffith Stadium (6-3) | 56-69 | |
| » Starters: George Grant vs Lloyd Brown | Sixth | 27 out |
| Sunday, August 26 |
| » Lost to Senators (57-68), 5-1 | Griffith Stadium (6-4) | 56-70 | Lost 2 |
| » Starters: Johnny Miljus vs Garland Braxton | Sixth | 27½ out |
| Monday, August 27 |
| » Defeated Senators (57-69), 5-3 | Griffith Stadium (7-4) | 57-70 | |
| » Starters: George Uhle vs Bump Hadley | Sixth | 28 out |
| » Major-league debuts: Jim Weaver (Senators) |
| Tuesday, August 28 |
| » Lost to Tigers (57-69), 8-4 | Tiger Stadium (5-4) | 57-71 | |
| » Starters: Jake Miller vs Sam Gibson | Sixth | 28½ out |
| Wednesday, August 29 |
| » Defeated Tigers (57-70), 9-5 | Tiger Stadium (6-4) | 58-71 | |
| » Starters: Joe Shaute vs Lil Stoner | Fifth | 28 out |
| Thursday, August 30 |
| » Lost to Tigers (58-70), 5-3 | Tiger Stadium (6-5) | 58-72 | |
| » Starters: Willis Hudlin vs Vic Sorrell | Sixth | 28 out |
| Saturday, September 1 |
| » Defeated White Sox (56-71), 6-2 | Comiskey Park I (6-4) | 59-72 | |
| » Starters: Johnny Miljus vs Red Faber | Sixth | 28 out |
| Sunday, September 2 |
| » Lost to White Sox (57-71), 3-1 | Comiskey Park I (6-5) | 59-73 | |
| » Starters: Jake Miller vs Tommy Thomas | Sixth | 28 out |
| Monday, September 3 |
| » Lost to Browns (71-61), 5-3 | Sportsman's Park III (4-5) | 59-74 | Lost 2 |
| » Starters: Joe Shaute vs George Blaeholder | Seventh | 29 out |
| » Lost to Browns (72-61), 16-10 | Sportsman's Park III (4-6) | 59-75 | Lost 3 |
| » Starters: George Uhle vs Lefty Stewart | Seventh | 29 out |
| Tuesday, September 4 |
| » Lost to Browns (73-61), 9-6 | Sportsman's Park III (4-7) | 59-76 | Lost 4 |
| » Starters: Willis Hudlin vs Alvin Crowder | Fifth | 29½ out |
| Thursday, September 6 |
| » Lost to White Sox (62-72), 2-1 | League Park II (25-34) | 59-77 | Lost 5 |
| » Starters: Tommy Thomas vs Johnny Miljus | Sixth | 30 out |
| Saturday, September 8 |
| » Lost to White Sox (63-72), 8-7 | League Park II (25-35) | 59-78 | Lost 6 |
| » Starters: Grady Adkins vs Willie Underhill | Seventh | 30½ out |
| Sunday, September 9 |
| » Lost to White Sox (64-72), 10-1 | League Park II (25-36) | 59-79 | Lost 7 |
| » Starters: Ted Lyons vs Willis Hudlin | Seventh | 31½ out |
| Monday, September 10 |
| » Lost to Browns (75-62), 5-3 | League Park II (25-37) | 59-80 | Lost 8 |
| » Starters: George Blaeholder vs Joe Shaute | Seventh | 32 out |
| Tuesday, September 11 |
| » Lost to Browns (76-62), 16-6 | League Park II (25-38) | 59-81 | Lost 9 |
| » Starters: Lefty Stewart vs Jake Miller | Seventh | 33 out |
| Saturday, September 15 |
| » Lost to Athletics (91-50), 5-0 | League Park II (25-39) | 59-82 | Lost 10 |
| » Starters: Jack Quinn vs Willis Hudlin | Seventh | 32½ out |
| Sunday, September 16 |
| » Lost to Athletics (92-50), 7-1 | League Park II (25-40) | 59-83 | Lost 11 |
| » Starters: Lefty Grove vs Joe Shaute | Seventh | 33½ out |
| Future Indian Vito Valentinetti is born in West New York, NJ. |
| Tuesday, September 18 |
| » Defeated Athletics (92-51), 3-2 | League Park II (26-40) | 60-83 | |
| » Starters: Rube Walberg vs Jake Miller | Sixth | 34 out |
| Friday, September 21 |
| » Lost to Senators (69-76), 2-1 | League Park II (26-41) | 60-84 | |
| » Starters: Garland Braxton vs Willie Underhill | Seventh | 35 out |
| » Lost to Senators (70-76), 2-1 | League Park II (26-42) | 60-85 | Lost 2 |
| » Starters: Sam Jones vs Jim Moore | Seventh | 35 out |
| » Major-league debuts: Jim Moore (Indians) |
| Saturday, September 22 |
| » Lost to Senators (71-76), 6-0 | League Park II (26-43) | 60-86 | Lost 3 |
| » Starters: Bump Hadley vs Wes Ferrell | Seventh | 35 out |
| Sunday, September 23 |
| » Lost to Yankees (96-51), 5-0 | League Park II (26-44) | 60-87 | Lost 4 |
| » Starters: Waite Hoyt vs Joe Shaute | Sixth | 36 out |
| Monday, September 24 |
| » Defeated Yankees (96-52), 4-3 | League Park II (27-44) | 61-87 | |
| » Starters: George Pipgras vs Jake Miller | Seventh | 35 out |
| Tuesday, September 25 |
| » Lost to Yankees (97-52), 10-1 | League Park II (27-45) | 61-88 | |
| » Starters: Tom Zachary vs George Grant | Seventh | 36 out |
| Thursday, September 27 |
| » Defeated Red Sox (53-96), 14-10 | League Park II (28-45) | 62-88 | |
| » Starters: Red Ruffing vs Willie Underhill | Seventh | 37 out |
| » Lost to Red Sox (54-96), 7-4 | League Park II (28-46) | 62-89 | |
| » Starters: Ed Morris vs Mel Harder | Seventh | 37 out |
| » Major-league debuts: Clint Brown (Indians) |
| Friday, September 28 |
| » Lost to Red Sox (55-96), 1-0 | League Park II (28-47) | 62-90 | Lost 2 |
| » Starters: Jack Russell vs Wes Ferrell | Seventh | 38 out |
| Saturday, September 29 |
| » Lost to Red Sox (56-96), 6-5 | League Park II (28-48) | 62-91 | Lost 3 |
| » Starters: Merle Settlemire vs Clint Brown | Seventh | 38 out |
| Sunday, September 30 |
| » Lost to Red Sox (57-96), 7-2 | League Park II (28-49) | 62-92 | Lost 4 |
| » Starters: Danny MacFayden vs Les Barnhart | Seventh | 39 out |
| Monday, October 1 |
| Future Indian Hal Naragon is born in Zanesville, OH. |
| Sunday, October 21 |
| Future Indian Valmy Thomas is born in Santurce, P.R. |
| Sunday, November 25 |
| Future Indian Ray Narleski is born in Camden, NJ. |
Game information provided by Retrosheet (www.retrosheet.org) |