| Thursday, March 18 |
| Future Red Sox Dick Littlefield is born in Detroit, MI. |
| Monday, March 22 |
| Future Red Sox Billy Goodman is born in Concord, NC. |
| Tuesday, April 13 |
| » Lost to Yankees (1-0), 12-11 | Fenway Park (0-1) | 0-1 | |
| » Starters: Bob Shawkey vs Howard Ehmke | Second | 1 out |
| » Major-league debuts: Sam Langford, Tony Welzer and Hal Wiltse (Red Sox) Tony Lazzeri (Yankees) |
| Wednesday, April 14 |
| » Defeated Yankees (1-1), 8-7 | Fenway Park (1-1) | 1-1 | |
| » Starters: Waite Hoyt vs Red Ruffing | Third | 1 out |
| » Major-league debuts: Nick Cullop (Yankees) |
| Friday, April 16 |
| » Lost to Yankees (2-1), 3-2 | Fenway Park (1-2) | 1-2 | |
| » Starters: Herb Pennock vs Paul Zahniser | Fifth | 2 out |
| Saturday, April 17 |
| » Defeated Athletics (1-4), 6-1 | Fenway Park (2-2) | 2-2 | |
| » Starters: Slim Harriss vs Howard Ehmke | Fourth | 1 out |
| Monday, April 19 |
| » Lost to Athletics (2-4), 3-1 | Fenway Park (2-3) | 2-3 | |
| » Starters: Lefty Grove vs Ted Wingfield | Third | 1 out |
| » Defeated Athletics (2-5), 2-1 | Fenway Park (3-3) | 3-3 | |
| » Starters: Dolly Gray vs Red Ruffing | Third | 1 out |
| Wednesday, April 21 |
| » Lost to Yankees (5-2), 8-5 | Yankee Stadium (0-1) | 3-4 | |
| » Starters: Howard Ehmke vs Sam Jones | Fourth | 2 out |
| Thursday, April 22 |
| » Defeated Yankees (5-3), 9-8 | Yankee Stadium (1-1) | 4-4 | |
| » Starters: Tony Welzer vs Myles Thomas | Fifth | 1½ out |
| Friday, April 23 |
| » Lost to Yankees (6-3), 3-1 | Yankee Stadium (1-2) | 4-5 | |
| » Starters: Red Ruffing vs Herb Pennock | Sixth | 2½ out |
| Saturday, April 24 |
| » Lost to Yankees (7-3), 9-1 | Yankee Stadium (1-3) | 4-6 | Lost 2 |
| » Starters: Hal Wiltse vs Urban Shocker | Fifth | 3½ out |
| Sunday, April 25 |
| » Defeated Senators (6-6), 8-6 | Griffith Stadium (1-0) | 5-6 | |
| » Starters: Ted Wingfield vs Stan Coveleski | Fifth | 3 out |
| Monday, April 26 |
| » Lost to Senators (7-6), 6-2 | Griffith Stadium (1-1) | 5-7 | |
| » Starters: Howard Ehmke vs Dutch Ruether | Fourth | 3½ out |
| Tuesday, April 27 |
| » Lost to Senators (8-6), 9-1 | Griffith Stadium (1-2) | 5-8 | Lost 2 |
| » Starters: Tony Welzer vs Walter Johnson | Fourth | 4½ out |
| Wednesday, April 28 |
| » Lost to Senators (9-6), 5-2 | Griffith Stadium (1-3) | 5-9 | Lost 3 |
| » Starters: Hal Wiltse vs Curly Ogden | Fourth | 5½ out |
| Thursday, April 29 |
| » Lost to Athletics (5-10), 4-0 | Shibe Park (0-1) | 5-10 | Lost 4 |
| » Starters: Red Ruffing vs Jack Quinn | Sixth | 6½ out |
| Friday, April 30 |
| » Lost to Athletics (6-10), 5-2 | Shibe Park (0-2) | 5-11 | Lost 5 |
| » Starters: Howard Ehmke vs Dolly Gray | Seventh | 7½ out |
| Saturday, May 1 |
| » Defeated Athletics (6-11), 2-1 | Shibe Park (1-2) | 6-11 | |
| » Starters: Ted Wingfield vs Eddie Rommel | Sixth | 7½ out |
| Monday, May 3 |
| » Lost to Senators (11-9), 6-2 | Fenway Park (3-4) | 6-12 | |
| » Starters: Curly Ogden vs Red Ruffing | Seventh | 7½ out |
| Tuesday, May 4 |
| » Lost to Senators (12-9), 8-7 | Fenway Park (3-5) | 6-13 | Lost 2 |
| » Starters: Joe Bush vs Howard Ehmke | Seventh | 7½ out |
| Wednesday, May 5 |
| » Lost to Senators (13-9), 11-0 | Fenway Park (3-6) | 6-14 | Lost 3 |
| » Starters: Stan Coveleski vs Ted Wingfield | Eighth | 7½ out |
| » Major-league debuts: Jack Russell (Red Sox) |
| Thursday, May 6 |
| » Defeated Indians (12-9), 1-0 | Fenway Park (4-6) | 7-14 | |
| » Starters: Sherry Smith vs Hal Wiltse | Seventh | 6½ out |
| Friday, May 7 |
| » Lost to Indians (13-9), 11-2 | Fenway Park (4-7) | 7-15 | |
| » Starters: Joe Shaute vs Joe Kiefer | Seventh | 7½ out |
| Saturday, May 8 |
| » Lost to Indians (14-9), 10-4 | Fenway Park (4-8) | 7-16 | Lost 2 |
| » Starters: Dutch Levsen vs Red Ruffing | Seventh | 7½ out |
| Monday, May 10 |
| » Lost to Indians (15-9), 3-0 | Fenway Park (4-9) | 7-17 | Lost 3 |
| » Starters: George Uhle vs Howard Ehmke | Sixth | 8 out |
| Wednesday, May 12 |
| » Defeated Tigers (11-14), 4-2 | Fenway Park (5-9) | 8-17 | |
| » Starters: Ken Holloway vs Hal Wiltse | Seventh | 8 out |
| Thursday, May 13 |
| » Lost to Tigers (12-14), 13-10 | Fenway Park (5-10) | 8-18 | |
| » Starters: Lil Stoner vs Red Ruffing | Seventh | 9 out |
| Friday, May 14 |
| » Lost to Tigers (13-14), 8-1 | Fenway Park (5-11) | 8-19 | Lost 2 |
| » Starters: Earl Whitehill vs Del Lundgren | Seventh | 10 out |
| Sunday, May 16 |
| » Lost to Tigers (14-15), 6-5 | Tiger Stadium (0-1) | 8-20 | Lost 3 |
| » Starters: Red Ruffing vs Ken Holloway | Seventh | 11 out |
| Tuesday, May 18 |
| » Defeated Browns (8-23), 6-3 | Fenway Park (6-11) | 9-20 | |
| » Starters: Charlie Robertson vs Howard Ehmke | Seventh | 11½ out |
| Wednesday, May 19 |
| » Lost to White Sox (18-16), 9-7 | Fenway Park (6-12) | 9-21 | |
| » Starters: Ted Lyons vs Hal Wiltse | Seventh | 12½ out |
| Thursday, May 20 |
| » Lost to White Sox (19-16), 13-4 | Fenway Park (6-13) | 9-22 | Lost 2 |
| » Starters: Dixie Leverett vs Ted Wingfield | Seventh | 13½ out |
| Friday, May 21 |
| » Defeated White Sox (19-17), 8-7 | Fenway Park (7-13) | 10-22 | |
| » Starters: Ted Blankenship vs Paul Zahniser | Seventh | 13½ out |
| Saturday, May 22 |
| » Defeated White Sox (19-18), 14-8 | Fenway Park (8-13) | 11-22 | Won 2 |
| » Starters: Sloppy Thurston vs Howard Ehmke | Seventh | 13½ out |
| Sunday, May 23 |
| » Lost to Yankees (26-9), 8-3 | Yankee Stadium (1-4) | 11-23 | |
| » Starters: Ted Wingfield vs Waite Hoyt | Seventh | 14½ out |
| Monday, May 24 |
| » Lost to Yankees (27-9), 4-2 | Fenway Park (8-14) | 11-24 | Lost 2 |
| » Starters: Urban Shocker vs Hal Wiltse | Seventh | 15½ out |
| Tuesday, May 25 |
| » Lost to Yankees (28-9), 5-3 | Fenway Park (8-15) | 11-25 | Lost 3 |
| » Starters: Myles Thomas vs Paul Zahniser | Seventh | 17½ out |
| » Lost to Yankees (29-9), 5-4 | Fenway Park (8-16) | 11-26 | Lost 4 |
| » Starters: Herb Pennock vs Howard Ehmke | Seventh | 17½ out |
| Wednesday, May 26 |
| » Lost to Yankees (30-9), 9-8 | Fenway Park (8-17) | 11-27 | Lost 5 |
| » Starters: Sam Jones vs Red Ruffing | Seventh | 18½ out |
| Saturday, May 29 |
| » Lost to Senators (23-20), 4-2 | Griffith Stadium (1-4) | 11-28 | Lost 6 |
| » Starters: Tony Welzer vs Stan Coveleski | Eighth | 17½ out |
| Sunday, May 30 |
| » Lost to Senators (24-20), 4-3 | Griffith Stadium (1-5) | 11-29 | Lost 7 |
| » Starters: Hal Wiltse vs Curly Ogden | Eighth | 18½ out |
| Monday, May 31 |
| » Defeated Athletics (26-20), 2-0 | Fenway Park (9-17) | 12-29 | |
| » Starters: Lefty Grove vs Howard Ehmke | Eighth | 18½ out |
| » Lost to Athletics (27-20), 8-2 | Fenway Park (9-18) | 12-30 | |
| » Starters: Dolly Gray vs Paul Zahniser | Eighth | 18½ out |
| Wednesday, June 2 |
| » Defeated Athletics (27-21), 5-4 | Fenway Park (10-18) | 13-30 | |
| » Starters: Slim Harriss vs Ted Wingfield | Eighth | 19½ out |
| » Lost to Athletics (28-21), 5-1 | Fenway Park (10-19) | 13-31 | |
| » Starters: Jack Quinn vs Red Ruffing | Eighth | 19½ out |
| » Major-league debuts: Bill Regan (Red Sox) |
| Thursday, June 3 |
| » Lost to Yankees (34-12), 8-5 | Yankee Stadium (1-5) | 13-32 | Lost 2 |
| » Starters: Hal Wiltse vs Myles Thomas | Eighth | 20½ out |
| Saturday, June 5 |
| » Lost to White Sox (26-23), 8-2 | Comiskey Park I (0-1) | 13-33 | Lost 3 |
| » Starters: Howard Ehmke vs Ted Lyons | Eighth | 20½ out |
| Sunday, June 6 |
| » Defeated White Sox (26-24), 4-3 | Comiskey Park I (1-1) | 14-33 | |
| » Starters: Paul Zahniser vs Ted Blankenship | Seventh | 20½ out |
| Monday, June 7 |
| » Lost to White Sox (27-24), 10-5 | Comiskey Park I (1-2) | 14-34 | |
| » Starters: Red Ruffing vs Tommy Thomas | Seventh | 20½ out |
| Tuesday, June 8 |
| » Lost to Browns (18-33), 6-5 | Sportsman's Park III (0-1) | 14-35 | Lost 2 |
| » Starters: Hal Wiltse vs Tom Zachary | Eighth | 21½ out |
| Wednesday, June 9 |
| » Lost to Browns (19-33), 6-4 | Sportsman's Park III (0-2) | 14-36 | Lost 3 |
| » Starters: Jack Russell vs Joe Giard | Eighth | 22½ out |
| Thursday, June 10 |
| » Defeated Browns (19-34), 8-3 | Sportsman's Park III (1-2) | 15-36 | |
| » Starters: Paul Zahniser vs Elam Vangilder | Eighth | 22½ out |
| Friday, June 11 |
| » Lost to Browns (20-34), 4-3 | Sportsman's Park III (1-3) | 15-37 | |
| » Starters: Howard Ehmke vs Milt Gaston | Eighth | 23½ out |
| Saturday, June 12 |
| » Lost to Tigers (27-29), 5-0 | Tiger Stadium (0-2) | 15-38 | Lost 2 |
| » Starters: Ted Wingfield vs Ed Wells | Seventh | 23½ out |
| Sunday, June 13 |
| » Defeated Tigers (27-30), 7-3 | Tiger Stadium (1-2) | 16-38 | |
| » Starters: Hal Wiltse vs Sam Gibson | Seventh | 23½ out |
| Monday, June 14 |
| » Lost to Tigers (28-30), 8-7 | Tiger Stadium (1-3) | 16-39 | |
| » Starters: Jack Russell vs Earl Whitehill | Eighth | 23½ out |
| Tuesday, June 15 |
| » Lost to Tigers (29-30), 7-6 | Tiger Stadium (1-4) | 16-40 | Lost 2 |
| » Starters: Howard Ehmke vs Lil Stoner | Eighth | 24½ out |
| Thursday, June 17 |
| » Lost to Indians (32-27), 3-1 | League Park II (0-1) | 16-41 | Lost 3 |
| » Starters: Paul Zahniser vs Sherry Smith | Eighth | 24½ out |
| Friday, June 18 |
| » Lost to Indians (33-27), 6-2 | League Park II (0-2) | 16-42 | Lost 4 |
| » Starters: Hal Wiltse vs George Uhle | Seventh | 25½ out |
| Saturday, June 19 |
| » Defeated Indians (33-28), 8-3 | League Park II (1-2) | 17-42 | |
| » Starters: Jack Russell vs Dutch Levsen | Seventh | 25½ out |
| Sunday, June 20 |
| » Lost to Indians (34-28), 1-0 | League Park II (1-3) | 17-43 | |
| » Starters: Fred Heimach vs Jake Miller | Seventh | 25½ out |
| Monday, June 21 |
| » Lost to Athletics (35-29), 7-6 | Shibe Park (1-3) | 17-44 | Lost 2 |
| » Starters: Paul Zahniser vs Howard Ehmke | Eighth | 26 out |
| Thursday, June 24 |
| » Defeated Yankees (44-20), 6-5 | Fenway Park (11-19) | 18-44 | |
| » Starters: Herb Pennock vs Hal Wiltse | Seventh | 25 out |
| Friday, June 25 |
| » Lost to Yankees (45-20), 12-2 | Fenway Park (11-20) | 18-45 | |
| » Starters: Sam Jones vs Fred Heimach | Seventh | 27 out |
| » Lost to Yankees (46-20), 11-4 | Fenway Park (11-21) | 18-46 | Lost 2 |
| » Starters: Urban Shocker vs Paul Zahniser | Seventh | 27 out |
| Sunday, June 27 |
| » Lost to Yankees (47-20), 7-1 | Yankee Stadium (1-6) | 18-47 | Lost 3 |
| » Starters: Fred Heimach vs Walter Beall | Eighth | 28 out |
| Monday, June 28 |
| » Defeated Senators (33-33), 6-2 | Fenway Park (12-21) | 19-47 | |
| » Starters: Curly Ogden vs Hal Wiltse | Seventh | 27 out |
| Tuesday, June 29 |
| » Defeated Senators (33-34), 2-1 | Fenway Park (13-21) | 20-47 | Won 2 |
| » Starters: Stan Coveleski vs Slim Harriss | Seventh | 27 out |
| Wednesday, June 30 |
| » Lost to Senators (34-34), 8-5 | Fenway Park (13-22) | 20-48 | |
| » Starters: Bill Morrell vs Ted Wingfield | Seventh | 27 out |
| » Major-league debuts: Danny Taylor (Senators) |
| Thursday, July 1 |
| » Defeated Athletics (37-35), 10-5 | Shibe Park (2-3) | 21-48 | |
| » Starters: Fred Heimach vs Lefty Grove | Seventh | 26½ out |
| Friday, July 2 |
| » Lost to Athletics (38-35), 4-3 | Shibe Park (2-4) | 21-49 | |
| » Starters: Hal Wiltse vs Howard Ehmke | Seventh | 26½ out |
| Saturday, July 3 |
| » Lost to Athletics (39-35), 12-4 | Shibe Park (2-5) | 21-50 | Lost 2 |
| » Starters: Slim Harriss vs Eddie Rommel | Seventh | 28 out |
| » Lost to Athletics (40-35), 8-5 | Shibe Park (2-6) | 21-51 | Lost 3 |
| » Starters: Ted Wingfield vs Dolly Gray | Seventh | 28 out |
| Monday, July 5 |
| » Lost to Senators (37-36), 7-4 | Griffith Stadium (1-6) | 21-52 | Lost 4 |
| » Starters: Fred Heimach vs Walter Johnson | Eighth | 28 out |
| » Lost to Senators (38-36), 3-2 | Griffith Stadium (1-7) | 21-53 | Lost 5 |
| » Starters: Slim Harriss vs Firpo Marberry | Eighth | 28 out |
| Wednesday, July 7 |
| » Lost to Athletics (43-35), 6-5 | Shibe Park (2-7) | 21-54 | Lost 6 |
| » Starters: Red Ruffing vs Eddie Rommel | Eighth | 28 out |
| » Defeated Athletics (43-36), 4-2 | Shibe Park (3-7) | 22-54 | |
| » Starters: Paul Zahniser vs Jack Quinn | Eighth | 28 out |
| Thursday, July 8 |
| » Defeated Tigers (38-41), 7-3 | Fenway Park (14-22) | 23-54 | Won 2 |
| » Starters: Ed Wells vs Hal Wiltse | Eighth | 27 out |
| Future Red Sox Gene Patton is born in Coatesville, PA. |
| Friday, July 9 |
| » Lost to Tigers (39-41), 9-0 | Fenway Park (14-23) | 23-55 | |
| » Starters: Rip Collins vs Fred Heimach | Eighth | 28 out |
| Saturday, July 10 |
| » Defeated Tigers (39-42), 6-5 | Fenway Park (15-23) | 24-55 | |
| » Starters: Sam Gibson vs Slim Harriss | Eighth | 28½ out |
| » Lost to Tigers (40-42), 4-2 | Fenway Park (15-24) | 24-56 | |
| » Starters: Lil Stoner vs Hal Wiltse | Eighth | 28½ out |
| Monday, July 12 |
| » Lost to Tigers (41-42), 5-2 | Fenway Park (15-25) | 24-57 | Lost 2 |
| » Starters: Rip Collins vs Paul Zahniser | Eighth | 28 out |
| Tuesday, July 13 |
| » Lost to Indians (45-40), 6-1 | Fenway Park (15-26) | 24-58 | Lost 3 |
| » Starters: Benn Karr vs Hal Wiltse | Seventh | 28 out |
| Thursday, July 15 |
| » Lost to Indians (46-40), 4-2 | Fenway Park (15-27) | 24-59 | Lost 4 |
| » Starters: Sherry Smith vs Red Ruffing | Eighth | 28 out |
| » Defeated Indians (46-41), 6-2 | Fenway Park (16-27) | 25-59 | |
| » Starters: Joe Shaute vs Fred Heimach | Eighth | 28 out |
| Saturday, July 17 |
| » Defeated White Sox (46-41), 3-2 | Fenway Park (17-27) | 26-59 | Won 2 |
| » Starters: Ted Blankenship vs Slim Harriss | Eighth | 28 out |
| » Defeated White Sox (46-42), 4-3 | Fenway Park (18-27) | 27-59 | Won 3 |
| » Starters: Ted Lyons vs Ted Wingfield | Eighth | 28 out |
| Monday, July 19 |
| » Lost to White Sox (47-42), 5-4 | Fenway Park (18-28) | 27-60 | |
| » Starters: Tommy Thomas vs Fred Heimach | Eighth | 28½ out |
| Tuesday, July 20 |
| » Lost to White Sox (48-42), 13-2 | Fenway Park (18-29) | 27-61 | Lost 2 |
| » Starters: Red Faber vs Red Ruffing | Eighth | 28½ out |
| Wednesday, July 21 |
| » Lost to Browns (38-52), 11-1 | Fenway Park (18-30) | 27-62 | Lost 3 |
| » Starters: Elam Vangilder vs Paul Zahniser | Eighth | 29½ out |
| » Lost to Browns (39-52), 7-4 | Fenway Park (18-31) | 27-63 | Lost 4 |
| » Starters: Joe Giard vs Ted Wingfield | Eighth | 29½ out |
| Thursday, July 22 |
| » Lost to Browns (40-52), 5-4 | Fenway Park (18-32) | 27-64 | Lost 5 |
| » Starters: Ernie Wingard vs Slim Harriss | Eighth | 30½ out |
| Friday, July 23 |
| » Lost to Browns (41-52), 6-4 | Fenway Park (18-33) | 27-65 | Lost 6 |
| » Starters: Tom Zachary vs Tony Welzer | Eighth | 31½ out |
| Saturday, July 24 |
| » Defeated Browns (41-53), 14-9 | Fenway Park (19-33) | 28-65 | |
| » Starters: Win Ballou vs Fred Heimach | Eighth | 31½ out |
| » Tied Browns, 5-5 | Fenway Park (19-33) | 28-65 | |
| » Starters: Ernie Nevers vs Hal Wiltse | Eighth | 31½ out |
| Monday, July 26 |
| » Lost to Athletics (51-44), 5-0 | Shibe Park (3-8) | 28-66 | |
| » Starters: Paul Zahniser vs Eddie Rommel | Eighth | 32½ out |
| Tuesday, July 27 |
| » Defeated Tigers (51-47), 7-0 | Tiger Stadium (2-4) | 29-66 | |
| » Starters: Slim Harriss vs Sam Gibson | Eighth | 32½ out |
| Wednesday, July 28 |
| » Defeated Tigers (51-48), 5-4 | Tiger Stadium (3-4) | 30-66 | Won 2 |
| » Starters: Red Ruffing vs Rip Collins | Eighth | 32½ out |
| Thursday, July 29 |
| » Lost to Tigers (52-48), 6-5 | Tiger Stadium (3-5) | 30-67 | |
| » Starters: Hal Wiltse vs Lil Stoner | Eighth | 33½ out |
| Friday, July 30 |
| » Defeated Tigers (52-49), 4-3 | Tiger Stadium (4-5) | 31-67 | |
| » Starters: Paul Zahniser vs Earl Whitehill | Eighth | 33½ out |
| Saturday, July 31 |
| » Lost to Indians (58-44), 6-2 | League Park II (1-4) | 31-68 | |
| » Starters: Slim Harriss vs Sherry Smith | Eighth | 34½ out |
| Sunday, August 1 |
| » Lost to Indians (59-44), 2-1 | League Park II (1-5) | 31-69 | Lost 2 |
| » Starters: Red Ruffing vs Dutch Levsen | Eighth | 35½ out |
| Tuesday, August 3 |
| » Defeated Indians (59-45), 8-7 | League Park II (2-5) | 32-69 | |
| » Starters: Hal Wiltse vs Garland Buckeye | Eighth | 34½ out |
| » Defeated Indians (59-46), 2-0 | League Park II (3-5) | 33-69 | Won 2 |
| » Starters: Paul Zahniser vs Joe Shaute | Eighth | 34½ out |
| Wednesday, August 4 |
| » Lost to White Sox (53-52), 7-3 | Comiskey Park I (1-3) | 33-70 | |
| » Starters: Slim Harriss vs Ted Lyons | Eighth | 34½ out |
| Thursday, August 5 |
| » Lost to White Sox (54-52), 7-2 | Comiskey Park I (1-4) | 33-71 | Lost 2 |
| » Starters: Red Ruffing vs Tommy Thomas | Eighth | 35½ out |
| Friday, August 6 |
| » Lost to White Sox (55-52), 7-4 | Comiskey Park I (1-5) | 33-72 | Lost 3 |
| » Starters: Ted Wingfield vs Sarge Connally | Eighth | 36½ out |
| Saturday, August 7 |
| » Lost to Browns (46-61), 5-2 | Sportsman's Park III (1-4) | 33-73 | Lost 4 |
| » Starters: Paul Zahniser vs Win Ballou | Eighth | 36½ out |
| Sunday, August 8 |
| » Defeated Browns (46-62), 4-2 | Sportsman's Park III (2-4) | 34-73 | |
| » Starters: Hal Wiltse vs Ernie Nevers | Eighth | 35½ out |
| Monday, August 9 |
| » Defeated Browns (46-63), 7-5 | Sportsman's Park III (3-4) | 35-73 | Won 2 |
| » Starters: Slim Harriss vs Chet Falk | Eighth | 35½ out |
| Tuesday, August 10 |
| » Lost to Browns (47-63), 6-4 | Sportsman's Park III (3-5) | 35-74 | |
| » Starters: Fred Heimach vs Elam Vangilder | Eighth | 35½ out |
| Thursday, August 12 |
| » Lost to Athletics (60-52), 5-1 | Fenway Park (19-34) | 35-75 | Lost 2 |
| » Starters: Howard Ehmke vs Hal Wiltse | Eighth | 35 out |
| » Lost to Athletics (61-52), 5-0 | Fenway Park (19-35) | 35-76 | Lost 3 |
| » Starters: Eddie Rommel vs Paul Zahniser | Eighth | 35 out |
| Saturday, August 14 |
| » Defeated Athletics (61-53), 3-1 | Fenway Park (20-35) | 36-76 | |
| » Starters: Dolly Gray vs Red Ruffing | Eighth | 35½ out |
| » Lost to Athletics (62-53), 3-2 | Fenway Park (20-36) | 36-77 | |
| » Starters: Lefty Grove vs Slim Harriss | Eighth | 35½ out |
| Sunday, August 15 |
| » Lost to Yankees (74-43), 4-2 | Yankee Stadium (1-7) | 36-78 | Lost 2 |
| » Starters: Ted Wingfield vs Herb Pennock | Eighth | 35½ out |
| » Defeated Yankees (74-44), 5-3 | Yankee Stadium (2-7) | 37-78 | |
| » Starters: Paul Zahniser vs Myles Thomas | Eighth | 35½ out |
| Monday, August 16 |
| » Lost to Browns (50-65), 6-1 | Fenway Park (20-37) | 37-79 | |
| » Starters: Elam Vangilder vs Hal Wiltse | Eighth | 35½ out |
| » Defeated Browns (50-66), 7-1 | Fenway Park (21-37) | 38-79 | |
| » Starters: Milt Gaston vs Slim Harriss | Eighth | 35½ out |
| Tuesday, August 17 |
| » Defeated Browns (50-67), 5-1 | Fenway Park (22-37) | 39-79 | Won 2 |
| » Starters: Tom Zachary vs Fred Heimach | Eighth | 34 out |
| » Defeated Browns (50-68), 4-0 | Fenway Park (23-37) | 40-79 | Won 3 |
| » Starters: Ernie Nevers vs Tony Welzer | Eighth | 34 out |
| Wednesday, August 18 |
| » Defeated Browns (50-69), 4-2 | Fenway Park (24-37) | 41-79 | Won 4 |
| » Starters: Dixie Davis vs Red Ruffing | Eighth | 33½ out |
| Thursday, August 19 |
| » Defeated White Sox (58-59), 1-0 | Fenway Park (25-37) | 42-79 | Won 5 |
| » Starters: Tommy Thomas vs Ted Wingfield | Seventh | 33 out |
| Friday, August 20 |
| » Lost to White Sox (59-59), 5-1 | Fenway Park (25-38) | 42-80 | |
| » Starters: Red Faber vs Paul Zahniser | Eighth | 34 out |
| Saturday, August 21 |
| » Lost to White Sox (60-59), 6-0 | Fenway Park (25-39) | 42-81 | Lost 2 |
| » Starters: Ted Lyons vs Slim Harriss | Eighth | 35 out |
| Monday, August 23 |
| » Lost to Tigers (63-57), 9-1 | Fenway Park (25-40) | 42-82 | Lost 3 |
| » Starters: Rip Collins vs Hal Wiltse | Eighth | 36 out |
| Wednesday, August 25 |
| » Lost to Tigers (64-57), 11-4 | Fenway Park (25-41) | 42-83 | Lost 4 |
| » Starters: Sam Gibson vs Ted Wingfield | Eighth | 36½ out |
| » Lost to Tigers (65-57), 7-6 | Fenway Park (25-42) | 42-84 | Lost 5 |
| » Starters: Lil Stoner vs Slim Harriss | Eighth | 36½ out |
| » Major-league debuts: Danny MacFayden (Red Sox) |
| Future Red Sox Jim Suchecki is born in Chicago, IL. |
| Friday, August 27 |
| » Lost to Indians (69-55), 9-3 | Fenway Park (25-43) | 42-85 | Lost 6 |
| » Starters: Joe Shaute vs Paul Zahniser | Eighth | 38 out |
| » Lost to Indians (70-55), 5-4 | Fenway Park (25-44) | 42-86 | Lost 7 |
| » Starters: Jake Miller vs Fred Heimach | Eighth | 38 out |
| Saturday, August 28 |
| » Lost to Indians (71-55), 6-1 | Fenway Park (25-45) | 42-87 | Lost 8 |
| » Starters: Dutch Levsen vs Hal Wiltse | Eighth | 38½ out |
| » Lost to Indians (72-55), 5-1 | Fenway Park (25-46) | 42-88 | Lost 9 |
| » Starters: Dutch Levsen vs Slim Harriss | Eighth | 38½ out |
| Tuesday, August 31 |
| » Lost to Senators (66-60), 2-0 | Fenway Park (25-47) | 42-89 | Lost 10 |
| » Starters: Stan Coveleski vs Jack Russell | Eighth | 38½ out |
| Wednesday, September 1 |
| » Lost to Senators (67-60), 14-12 | Fenway Park (25-48) | 42-90 | Lost 11 |
| » Starters: George Murray vs Slim Harriss | Eighth | 39½ out |
| Friday, September 3 |
| » Lost to Senators (68-60), 3-2 | Fenway Park (25-49) | 42-91 | Lost 12 |
| » Starters: Alvin Crowder vs Hal Wiltse | Eighth | 40½ out |
| » Lost to Senators (69-60), 5-1 | Fenway Park (25-50) | 42-92 | Lost 13 |
| » Starters: George Murray vs Paul Zahniser | Eighth | 40½ out |
| Saturday, September 4 |
| » Lost to Senators (70-60), 5-1 | Fenway Park (25-51) | 42-93 | Lost 14 |
| » Starters: Walter Johnson vs Danny MacFayden | Eighth | 41½ out |
| Sunday, September 5 |
| » Lost to Senators (71-60), 6-2 | Griffith Stadium (1-8) | 42-94 | Lost 15 |
| » Starters: Jack Russell vs Stan Coveleski | Eighth | 42 out |
| Monday, September 6 |
| » Lost to Senators (72-60), 2-1 | Griffith Stadium (1-9) | 42-95 | Lost 16 |
| » Starters: Slim Harriss vs Alvin Crowder | Eighth | 42½ out |
| Tuesday, September 7 |
| » Lost to Yankees (84-51), 4-2 | Yankee Stadium (2-8) | 42-96 | Lost 17 |
| » Starters: Ted Wingfield vs Urban Shocker | Eighth | 43½ out |
| Wednesday, September 8 |
| » Defeated Yankees (84-52), 5-2 | Yankee Stadium (3-8) | 43-96 | |
| » Starters: Hal Wiltse vs Sam Jones | Eighth | 42½ out |
| Thursday, September 9 |
| » Lost to Yankees (85-52), 10-0 | Yankee Stadium (3-9) | 43-97 | |
| » Starters: Paul Zahniser vs Bob Shawkey | Eighth | 43½ out |
| Saturday, September 11 |
| » Defeated Browns (56-83), 5-4 | Sportsman's Park III (4-5) | 44-97 | |
| » Starters: Del Lundgren vs Ernie Wingard | Eighth | 43½ out |
| Sunday, September 12 |
| » Defeated Browns (56-84), 11-3 | Sportsman's Park III (5-5) | 45-97 | Won 2 |
| » Starters: Hal Wiltse vs Elam Vangilder | Eighth | 43½ out |
| » Lost to Browns (57-84), 1-0 | Sportsman's Park III (5-6) | 45-98 | |
| » Starters: Red Ruffing vs Milt Gaston | Eighth | 43½ out |
| Wednesday, September 15 |
| » Lost to White Sox (72-70), 5-1 | Comiskey Park I (1-6) | 45-99 | Lost 2 |
| » Starters: Ted Wingfield vs Tommy Thomas | Eighth | 43½ out |
| Thursday, September 16 |
| » Lost to White Sox (73-70), 6-4 | Comiskey Park I (1-7) | 45-100 | Lost 3 |
| » Starters: Slim Harriss vs Ted Blankenship | Eighth | 43 out |
| Friday, September 17 |
| » Lost to White Sox (74-70), 3-2 | Comiskey Park I (1-8) | 45-101 | Lost 4 |
| » Starters: Red Ruffing vs Ted Lyons | Eighth | 43 out |
| Saturday, September 18 |
| » Lost to White Sox (75-70), 6-3 | Comiskey Park I (1-9) | 45-102 | Lost 5 |
| » Starters: Hal Wiltse vs Sarge Connally | Eighth | 43 out |
| Sunday, September 19 |
| » Lost to White Sox (76-70), 6-3 | Comiskey Park I (1-10) | 45-103 | Lost 6 |
| » Starters: Paul Zahniser vs Tommy Thomas | Eighth | 44 out |
| Future Red Sox Murray Wall is born in Dallas, TX. |
| Monday, September 20 |
| » Defeated Indians (85-63), 3-2 | League Park II (4-5) | 46-103 | |
| » Starters: Ted Wingfield vs Sherry Smith | Eighth | 42½ out |
| Tuesday, September 21 |
| » Lost to Indians (86-63), 6-1 | League Park II (4-6) | 46-104 | |
| » Starters: Red Ruffing vs George Uhle | Eighth | 43½ out |
| Wednesday, September 22 |
| » Lost to Indians (87-63), 5-1 | League Park II (4-7) | 46-105 | Lost 2 |
| » Starters: Fred Heimach vs Garland Buckeye | Eighth | 43½ out |
| Sunday, September 26 |
| » Lost to Tigers (78-75), 11-2 | Tiger Stadium (4-6) | 46-106 | Lost 3 |
| » Starters: Paul Zahniser vs Sam Gibson | Eighth | 44½ out |
| » Lost to Tigers (79-75), 5-4 | Tiger Stadium (4-7) | 46-107 | Lost 4 |
| » Starters: Ted Wingfield vs Rudy Kneisch | Eighth | 44½ out |
Game information provided by Retrosheet (www.retrosheet.org) |