| Wednesday, February 10 |
| Future Indian Randy Jackson is born in Little Rock, AR. |
| Thursday, February 25 |
| Former Indian Otto Hess dies in Tucson, AZ at the age of 48. |
| Tuesday, April 13 |
| » Defeated Tigers (0-1), 2-1 | Tiger Stadium (1-0) | 1-0 | |
| » Starters: George Uhle vs Earl Whitehill | First | -- |
| Wednesday, April 14 |
| » Major-league debuts: Nick Cullop (Yankees) |
| Friday, April 16 |
| » Lost to Tigers (1-1), 5-3 | Tiger Stadium (1-1) | 1-1 | |
| » Starters: Joe Shaute vs Augie Johns | Fourth | 1½ out |
| Saturday, April 17 |
| » Defeated White Sox (3-1), 2-0 | Comiskey Park I (1-0) | 2-1 | |
| » Starters: Jake Miller vs Tommy Thomas | Second | ½ out |
| » Major-league debuts: Bill Hunnefield and Tommy Thomas (White Sox) |
| Sunday, April 18 |
| » Lost to White Sox (4-1), 5-1 | Comiskey Park I (1-1) | 2-2 | |
| » Starters: George Uhle vs Ted Lyons | Fifth | 1½ out |
| Monday, April 19 |
| » Defeated White Sox (4-2), 5-1 | Comiskey Park I (2-1) | 3-2 | |
| » Starters: Sherry Smith vs Ted Blankenship | Second | ½ out |
| Tuesday, April 20 |
| » Defeated White Sox (4-3), 9-5 | Comiskey Park I (3-1) | 4-2 | Won 2 |
| » Starters: Joe Shaute vs Sloppy Thurston | First | -- |
| Wednesday, April 21 |
| » Defeated Tigers (4-3), 12-2 | League Park II (1-0) | 5-2 | Won 3 |
| » Starters: Augie Johns vs Benn Karr | First | -- |
| » Major-league debuts: George Smith (Tigers) |
| Friday, April 23 |
| » Defeated Tigers (4-4), 5-3 | League Park II (2-0) | 6-2 | Won 4 |
| » Starters: Ken Holloway vs George Uhle | First | -- |
| Saturday, April 24 |
| » Defeated Tigers (4-5), 4-3 | League Park II (3-0) | 7-2 | Won 5 |
| » Starters: Earl Whitehill vs Dutch Levsen | First | -- |
| Sunday, April 25 |
| » Lost to Browns (4-8), 11-5 | Sportsman's Park III (0-1) | 7-3 | |
| » Starters: Sherry Smith vs Tom Zachary | Second | ½ out |
| Monday, April 26 |
| » Defeated Browns (4-9), 12-1 | Sportsman's Park III (1-1) | 8-3 | |
| » Starters: Joe Shaute vs Joe Giard | First | -- |
| » Major-league debuts: Ernie Nevers (Browns) |
| Tuesday, April 27 |
| » Defeated Browns (4-10), 5-3 | Sportsman's Park III (2-1) | 9-3 | Won 2 |
| » Starters: Garland Buckeye vs Milt Gaston | First | -- |
| Wednesday, April 28 |
| » Defeated Browns (4-11), 7-3 | Sportsman's Park III (3-1) | 10-3 | Won 3 |
| » Starters: George Uhle vs Claude Jonnard | First | -- |
| Thursday, April 29 |
| » Lost to White Sox (10-6), 7-3 | League Park II (3-1) | 10-4 | |
| » Starters: Dixie Leverett vs Dutch Levsen | Second | 1 out |
| Friday, April 30 |
| » Lost to White Sox (11-6), 3-2 | League Park II (3-2) | 10-5 | Lost 2 |
| » Starters: Ted Lyons vs Sherry Smith | Second | 2 out |
| Saturday, May 1 |
| » Lost to White Sox (12-6), 9-6 | League Park II (3-3) | 10-6 | Lost 3 |
| » Starters: Red Faber vs Joe Shaute | Third | 3 out |
| Sunday, May 2 |
| » Lost to White Sox (13-6), 8-3 | League Park II (3-4) | 10-7 | Lost 4 |
| » Starters: Ted Blankenship vs Garland Buckeye | Third | 3½ out |
| Monday, May 3 |
| » Defeated Browns (6-14), 3-1 | League Park II (4-4) | 11-7 | |
| » Starters: Tom Zachary vs Dutch Levsen | Third | 2½ out |
| Tuesday, May 4 |
| » Defeated Browns (6-15), 11-5 | League Park II (5-4) | 12-7 | Won 2 |
| » Starters: Elam Vangilder vs George Uhle | Third | 1½ out |
| Wednesday, May 5 |
| » Lost to Browns (7-15), 11-5 | League Park II (5-5) | 12-8 | |
| » Starters: Chet Falk vs Garland Buckeye | Third | 1½ out |
| Thursday, May 6 |
| » Lost to Red Sox (7-14), 1-0 | Fenway Park (0-1) | 12-9 | Lost 2 |
| » Starters: Sherry Smith vs Hal Wiltse | Fourth | 1½ out |
| Friday, May 7 |
| » Defeated Red Sox (7-15), 11-2 | Fenway Park (1-1) | 13-9 | |
| » Starters: Joe Shaute vs Joe Kiefer | Fourth | 1½ out |
| Saturday, May 8 |
| » Defeated Red Sox (7-16), 10-4 | Fenway Park (2-1) | 14-9 | Won 2 |
| » Starters: Dutch Levsen vs Red Ruffing | Third | ½ out |
| Monday, May 10 |
| » Defeated Red Sox (7-17), 3-0 | Fenway Park (3-1) | 15-9 | Won 3 |
| » Starters: George Uhle vs Howard Ehmke | First | -- |
| Wednesday, May 12 |
| » Lost to Yankees (16-9), 6-5 | Yankee Stadium (0-1) | 15-10 | |
| » Starters: Sherry Smith vs Urban Shocker | Third | 1 out |
| Thursday, May 13 |
| » Lost to Yankees (17-9), 13-9 | Yankee Stadium (0-2) | 15-11 | Lost 2 |
| » Starters: Joe Shaute vs Waite Hoyt | Fourth | 2 out |
| Friday, May 14 |
| » Lost to Yankees (18-9), 2-1 | Yankee Stadium (0-3) | 15-12 | Lost 3 |
| » Starters: Dutch Levsen vs Myles Thomas | Fourth | 3 out |
| Saturday, May 15 |
| » Lost to Senators (20-12), 6-4 | Griffith Stadium (0-1) | 15-13 | Lost 4 |
| » Starters: George Uhle vs Stan Coveleski | Fifth | 4 out |
| Monday, May 17 |
| » Defeated Senators (20-13), 12-5 | Griffith Stadium (1-1) | 16-13 | |
| » Starters: Garland Buckeye vs Dutch Ruether | Fourth | 4 out |
| Tuesday, May 18 |
| » Defeated Senators (20-14), 4-2 | Griffith Stadium (2-1) | 17-13 | Won 2 |
| » Starters: Sherry Smith vs Walter Johnson | Third | 4 out |
| Wednesday, May 19 |
| » Defeated Athletics (18-15), 6-5 | Shibe Park (1-0) | 18-13 | Won 3 |
| » Starters: Dutch Levsen vs Lefty Grove | Second | 4 out |
| Thursday, May 20 |
| » Lost to Athletics (19-15), 10-2 | Shibe Park (1-1) | 18-14 | |
| » Starters: George Uhle vs Slim Harriss | Second | 5 out |
| Friday, May 21 |
| » Defeated Athletics (19-16), 4-3 | Shibe Park (2-1) | 19-14 | |
| » Starters: Garland Buckeye vs Eddie Rommel | Second | 5 out |
| Saturday, May 22 |
| » Defeated Athletics (19-17), 9-5 | Shibe Park (3-1) | 20-14 | Won 2 |
| » Starters: Joe Shaute vs Jack Quinn | Second | 5 out |
| Sunday, May 23 |
| » Lost to White Sox (20-18), 1-0 | League Park II (5-6) | 20-15 | |
| » Starters: Ted Lyons vs Sherry Smith | Second | 6 out |
| Monday, May 24 |
| » Lost to Browns (9-28), 8-5 | League Park II (5-7) | 20-16 | Lost 2 |
| » Starters: Milt Gaston vs Dutch Levsen | Second | 7 out |
| Tuesday, May 25 |
| » Defeated Browns (9-29), 6-4 | League Park II (6-7) | 21-16 | |
| » Starters: Tom Zachary vs George Uhle | Second | 7½ out |
| Wednesday, May 26 |
| » Lost to Tigers (20-18), 7-6 | League Park II (6-8) | 21-17 | |
| » Starters: Earl Whitehill vs Benn Karr | Second | 8½ out |
| Thursday, May 27 |
| » Lost to Browns (10-29), 8-5 | Sportsman's Park III (3-2) | 21-18 | Lost 2 |
| » Starters: Garland Buckeye vs Ernie Wingard | Third | 9 out |
| Friday, May 28 |
| » Lost to Browns (11-29), 4-3 | Sportsman's Park III (3-3) | 21-19 | Lost 3 |
| » Starters: Sherry Smith vs Charlie Robertson | Third | 8½ out |
| Saturday, May 29 |
| » Lost to Browns (12-29), 5-4 | Sportsman's Park III (3-4) | 21-20 | Lost 4 |
| » Starters: George Uhle vs Milt Gaston | Sixth | 8½ out |
| Sunday, May 30 |
| » Lost to Browns (13-29), 3-1 | Sportsman's Park III (3-5) | 21-21 | Lost 5 |
| » Starters: Dutch Levsen vs Tom Zachary | Sixth | 9½ out |
| Monday, May 31 |
| » Lost to White Sox (24-21), 3-1 | League Park II (6-9) | 21-22 | Lost 6 |
| » Starters: Ted Lyons vs Jake Miller | Sixth | 9½ out |
| » Defeated White Sox (24-22), 5-4 | League Park II (7-9) | 22-22 | |
| » Starters: Ted Blankenship vs Joe Shaute | Sixth | 9½ out |
| Wednesday, June 2 |
| » Defeated Tigers (23-23), 13-1 | League Park II (8-9) | 23-22 | Won 2 |
| » Starters: Lil Stoner vs Sherry Smith | Sixth | 10½ out |
| » Lost to Tigers (24-23), 7-0 | League Park II (8-10) | 23-23 | |
| » Starters: Ed Wells vs George Uhle | Sixth | 10½ out |
| Thursday, June 3 |
| » Lost to Tigers (25-23), 3-2 | League Park II (8-11) | 23-24 | Lost 2 |
| » Starters: Sam Gibson vs Dutch Levsen | Sixth | 11½ out |
| Friday, June 4 |
| » Defeated Tigers (25-24), 4-3 | League Park II (9-11) | 24-24 | |
| » Starters: Earl Whitehill vs Jake Miller | Sixth | 11 out |
| Saturday, June 5 |
| » Defeated Yankees (34-13), 15-3 | League Park II (10-11) | 25-24 | Won 2 |
| » Starters: Herb Pennock vs Garland Buckeye | Fifth | 10 out |
| Sunday, June 6 |
| » Lost to Yankees (35-13), 6-5 | League Park II (10-12) | 25-25 | |
| » Starters: Waite Hoyt vs Sherry Smith | Fifth | 11 out |
| Monday, June 7 |
| » Defeated Yankees (35-14), 5-2 | League Park II (11-12) | 26-25 | |
| » Starters: Urban Shocker vs George Uhle | Fifth | 10 out |
| Tuesday, June 8 |
| » Defeated Senators (25-24), 5-4 | League Park II (12-12) | 27-25 | Won 2 |
| » Starters: Curly Ogden vs Dutch Levsen | Fourth | 10 out |
| Wednesday, June 9 |
| » Defeated Senators (25-25), 11-5 | League Park II (13-12) | 28-25 | Won 3 |
| » Starters: Joe Bush vs Jake Miller | Fourth | 10 out |
| » Major-league debuts: Bobby Reeves (Senators) |
| Thursday, June 10 |
| » Lost to Senators (26-25), 5-3 | League Park II (13-13) | 28-26 | |
| » Starters: Stan Coveleski vs Garland Buckeye | Fourth | 11 out |
| Saturday, June 12 |
| » Defeated Athletics (31-25), 1-0 | League Park II (14-13) | 29-26 | |
| » Starters: Lefty Grove vs Sherry Smith | Third | 10½ out |
| Sunday, June 13 |
| » Defeated Athletics (31-26), 4-1 | League Park II (15-13) | 30-26 | Won 2 |
| » Starters: Dolly Gray vs George Uhle | Third | 10½ out |
| Monday, June 14 |
| » Defeated Athletics (31-27), 6-5 | League Park II (16-13) | 31-26 | Won 3 |
| » Starters: Eddie Rommel vs Dutch Levsen | Second | 9½ out |
| Future Indian Don Newcombe is born in Madison, NJ. |
| Tuesday, June 15 |
| » Lost to Athletics (32-27), 5-0 | League Park II (16-14) | 31-27 | |
| » Starters: Rube Walberg vs Jake Miller | Fourth | 10½ out |
| Thursday, June 17 |
| » Defeated Red Sox (16-41), 3-1 | League Park II (17-14) | 32-27 | |
| » Starters: Paul Zahniser vs Sherry Smith | Fourth | 9½ out |
| Friday, June 18 |
| » Defeated Red Sox (16-42), 6-2 | League Park II (18-14) | 33-27 | Won 2 |
| » Starters: Hal Wiltse vs George Uhle | Third | 9½ out |
| Saturday, June 19 |
| » Lost to Red Sox (17-42), 8-3 | League Park II (18-15) | 33-28 | |
| » Starters: Jack Russell vs Dutch Levsen | Third | 10½ out |
| Sunday, June 20 |
| » Defeated Red Sox (17-43), 1-0 | League Park II (19-15) | 34-28 | |
| » Starters: Fred Heimach vs Jake Miller | Second | 9½ out |
| Monday, June 21 |
| » Defeated White Sox (34-29), 5-2 | Comiskey Park I (4-1) | 35-28 | Won 2 |
| » Starters: Joe Shaute vs Tommy Thomas | Second | 9 out |
| Tuesday, June 22 |
| » Lost to White Sox (35-29), 4-3 | Comiskey Park I (4-2) | 35-29 | |
| » Starters: Sherry Smith vs Ted Lyons | Second | 9½ out |
| Wednesday, June 23 |
| » Lost to White Sox (36-29), 5-3 | Comiskey Park I (4-3) | 35-30 | Lost 2 |
| » Starters: George Uhle vs Ted Blankenship | Fourth | 10 out |
| Thursday, June 24 |
| » Lost to White Sox (37-29), 9-6 | Comiskey Park I (4-4) | 35-31 | Lost 3 |
| » Starters: Garland Buckeye vs Jim Joe Edwards | Third | 10 out |
| Saturday, June 26 |
| » Lost to Tigers (34-32), 5-0 | Tiger Stadium (1-2) | 35-32 | Lost 4 |
| » Starters: Benn Karr vs Ed Wells | Fourth | 12 out |
| » Lost to Tigers (35-32), 7-2 | Tiger Stadium (1-3) | 35-33 | Lost 5 |
| » Starters: Garland Buckeye vs Sam Gibson | Fourth | 12 out |
| Sunday, June 27 |
| » Lost to Tigers (36-32), 5-4 | Tiger Stadium (1-4) | 35-34 | Lost 6 |
| » Starters: Sherry Smith vs Earl Whitehill | Sixth | 13 out |
| » Major-league debuts: Ray Hayworth (Tigers) |
| Monday, June 28 |
| » Defeated Tigers (36-33), 8-4 | Tiger Stadium (2-4) | 36-34 | |
| » Starters: George Uhle vs Wilbur Cooper | Fourth | 12 out |
| Tuesday, June 29 |
| » Defeated White Sox (40-32), 4-2 | League Park II (20-15) | 37-34 | Won 2 |
| » Starters: Milt Steengrafe vs Joe Shaute | Third | 12 out |
| Wednesday, June 30 |
| » Defeated White Sox (40-33), 11-3 | League Park II (21-15) | 38-34 | Won 3 |
| » Starters: Ted Lyons vs Dutch Levsen | Third | 11 out |
| Thursday, July 1 |
| » Defeated Tigers (37-35), 11-6 | Tiger Stadium (3-4) | 39-34 | Won 4 |
| » Starters: Benn Karr vs Sam Gibson | Third | 10½ out |
| Friday, July 2 |
| » Lost to Tigers (38-35), 9-3 | Tiger Stadium (3-5) | 39-35 | |
| » Starters: Sherry Smith vs Hooks Dauss | Third | 10½ out |
| Saturday, July 3 |
| » Defeated Tigers (38-36), 7-5 | Tiger Stadium (4-5) | 40-35 | |
| » Starters: George Uhle vs Wilbur Cooper | Third | 10½ out |
| Sunday, July 4 |
| » Lost to Browns (31-44), 2-1 | League Park II (21-16) | 40-36 | |
| » Starters: Joe Giard vs Joe Shaute | Fourth | 11 out |
| Monday, July 5 |
| » Defeated White Sox (42-36), 4-2 | Comiskey Park I (5-4) | 41-36 | |
| » Starters: Dutch Levsen vs Ted Lyons | Fourth | 10 out |
| » Lost to White Sox (43-36), 8-0 | Comiskey Park I (5-5) | 41-37 | |
| » Starters: Garland Buckeye vs Tommy Thomas | Fourth | 10 out |
| Tuesday, July 6 |
| » Lost to White Sox (44-36), 8-0 | Comiskey Park I (5-6) | 41-38 | Lost 2 |
| » Starters: Benn Karr vs Ted Blankenship | Fourth | 10½ out |
| Thursday, July 8 |
| » Defeated Yankees (50-27), 6-1 | Yankee Stadium (1-3) | 42-38 | |
| » Starters: George Uhle vs Herb Pennock | Fourth | 9½ out |
| Friday, July 9 |
| » Lost to Yankees (51-27), 8-2 | Yankee Stadium (1-4) | 42-39 | |
| » Starters: Sherry Smith vs Sam Jones | Fourth | 10½ out |
| Saturday, July 10 |
| » Lost to Yankees (52-27), 4-3 | Yankee Stadium (1-5) | 42-40 | Lost 2 |
| » Starters: Joe Shaute vs Urban Shocker | Fifth | 11½ out |
| Sunday, July 11 |
| » Defeated Yankees (52-28), 8-3 | Yankee Stadium (2-5) | 43-40 | |
| » Starters: Dutch Levsen vs Myles Thomas | Fifth | 10½ out |
| Monday, July 12 |
| » Defeated Yankees (52-29), 6-2 | Yankee Stadium (3-5) | 44-40 | Won 2 |
| » Starters: George Uhle vs Bob Shawkey | Fifth | 9½ out |
| Tuesday, July 13 |
| » Defeated Red Sox (24-58), 6-1 | Fenway Park (4-1) | 45-40 | Won 3 |
| » Starters: Benn Karr vs Hal Wiltse | Fourth | 8½ out |
| Thursday, July 15 |
| » Defeated Red Sox (24-59), 4-2 | Fenway Park (5-1) | 46-40 | Won 4 |
| » Starters: Sherry Smith vs Red Ruffing | Fourth | 8½ out |
| » Lost to Red Sox (25-59), 6-2 | Fenway Park (5-2) | 46-41 | |
| » Starters: Joe Shaute vs Fred Heimach | Fourth | 8½ out |
| Friday, July 16 |
| » Defeated Senators (42-39), 8-0 | Griffith Stadium (3-1) | 47-41 | |
| » Starters: Dutch Levsen vs Walter Johnson | Fourth | 8½ out |
| Saturday, July 17 |
| » Lost to Senators (43-39), 5-3 | Griffith Stadium (3-2) | 47-42 | |
| » Starters: George Uhle vs Dutch Ruether | Third | 9½ out |
| Sunday, July 18 |
| » Defeated Senators (43-40), 5-3 | Griffith Stadium (4-2) | 48-42 | |
| » Starters: Benn Karr vs Stan Coveleski | Third | 8½ out |
| Monday, July 19 |
| » Lost to Senators (44-40), 4-1 | Griffith Stadium (4-3) | 48-43 | |
| » Starters: Jake Miller vs Firpo Marberry | Fourth | 9½ out |
| Tuesday, July 20 |
| » Defeated Senators (44-41), 9-2 | Griffith Stadium (5-3) | 49-43 | |
| » Starters: Sherry Smith vs Bill Morrell | Third | 8½ out |
| Wednesday, July 21 |
| » Defeated Athletics (49-42), 6-0 | Shibe Park (4-1) | 50-43 | Won 2 |
| » Starters: Dutch Levsen vs Howard Ehmke | Second | 8 out |
| Thursday, July 22 |
| » Defeated Athletics (49-43), 4-2 | Shibe Park (5-1) | 51-43 | Won 3 |
| » Starters: George Uhle vs Lefty Grove | Second | 8 out |
| Friday, July 23 |
| » Defeated Athletics (49-44), 8-5 | Shibe Park (6-1) | 52-43 | Won 4 |
| » Starters: Garland Buckeye vs Rube Walberg | Second | 8 out |
| Saturday, July 24 |
| » Lost to Athletics (50-44), 6-5 | Shibe Park (6-2) | 52-44 | |
| » Starters: Jake Miller vs Jack Quinn | Second | 9 out |
| Sunday, July 25 |
| » Defeated Browns (41-54), 7-4 | League Park II (22-16) | 53-44 | |
| » Starters: Joe Giard vs Sherry Smith | Second | 9 out |
| Wednesday, July 28 |
| » Defeated Athletics (51-45), 5-2 | League Park II (23-16) | 54-44 | Won 2 |
| » Starters: Rube Walberg vs Dutch Levsen | Second | 9 out |
| » Defeated Athletics (51-46), 2-0 | League Park II (24-16) | 55-44 | Won 3 |
| » Starters: Howard Ehmke vs George Uhle | Second | 9 out |
| Thursday, July 29 |
| » Defeated Athletics (51-47), 3-2 | League Park II (25-16) | 56-44 | Won 4 |
| » Starters: Lefty Grove vs Garland Buckeye | Second | 9 out |
| Friday, July 30 |
| » Defeated Athletics (51-48), 4-1 | League Park II (26-16) | 57-44 | Won 5 |
| » Starters: Eddie Rommel vs Joe Shaute | Second | 9 out |
| Saturday, July 31 |
| » Defeated Red Sox (31-68), 6-2 | League Park II (27-16) | 58-44 | Won 6 |
| » Starters: Slim Harriss vs Sherry Smith | Second | 9 out |
| Sunday, August 1 |
| » Defeated Red Sox (31-69), 2-1 | League Park II (28-16) | 59-44 | Won 7 |
| » Starters: Red Ruffing vs Dutch Levsen | Second | 9 out |
| Tuesday, August 3 |
| » Lost to Red Sox (32-69), 8-7 | League Park II (28-17) | 59-45 | |
| » Starters: Hal Wiltse vs Garland Buckeye | Second | 10 out |
| » Lost to Red Sox (33-69), 2-0 | League Park II (28-18) | 59-46 | Lost 2 |
| » Starters: Paul Zahniser vs Joe Shaute | Second | 10 out |
| Wednesday, August 4 |
| » Defeated Yankees (68-36), 4-2 | League Park II (29-18) | 60-46 | |
| » Starters: Waite Hoyt vs George Uhle | Second | 9 out |
| Thursday, August 5 |
| » Lost to Yankees (69-36), 8-2 | League Park II (29-19) | 60-47 | |
| » Starters: Sam Jones vs Sherry Smith | Second | 10 out |
| Friday, August 6 |
| » Lost to Yankees (70-36), 8-7 | League Park II (29-20) | 60-48 | Lost 2 |
| » Starters: Urban Shocker vs Dutch Levsen | Second | 11 out |
| Saturday, August 7 |
| » Defeated Senators (52-52), 8-5 | League Park II (30-20) | 61-48 | |
| » Starters: Alvin Crowder vs Joe Shaute | Second | 10½ out |
| » Lost to Senators (53-52), 9-2 | League Park II (30-21) | 61-49 | |
| » Starters: Stan Coveleski vs Jake Miller | Second | 10½ out |
| Sunday, August 8 |
| » Defeated Senators (53-53), 7-4 | League Park II (31-21) | 62-49 | |
| » Starters: George Murray vs George Uhle | Second | 9½ out |
| Monday, August 9 |
| » Defeated Senators (53-54), 7-5 | League Park II (32-21) | 63-49 | Won 2 |
| » Starters: Walter Johnson vs Sherry Smith | Second | 9½ out |
| Tuesday, August 10 |
| » Lost to Senators (54-54), 4-1 | League Park II (32-22) | 63-50 | |
| » Starters: Dutch Ruether vs Dutch Levsen | Second | 9½ out |
| Wednesday, August 11 |
| » Lost to White Sox (57-56), 7-2 | League Park II (32-23) | 63-51 | Lost 2 |
| » Starters: Jim Joe Edwards vs Joe Shaute | Second | 9 out |
| Thursday, August 12 |
| » Defeated White Sox (57-57), 5-0 | League Park II (33-23) | 64-51 | |
| » Starters: Red Faber vs Jake Miller | Second | 8 out |
| Sunday, August 15 |
| » Lost to Browns (49-64), 11-7 | League Park II (33-24) | 64-52 | |
| » Starters: Joe Giard vs Willis Hudlin | Second | 8½ out |
| » Defeated Browns (49-65), 6-4 | League Park II (34-24) | 65-52 | |
| » Starters: Ernie Wingard vs George Uhle | Second | 8½ out |
| » Major-league debuts: Willis Hudlin (Indians) |
| Tuesday, August 17 |
| » Lost to Athletics (63-54), 9-4 | Shibe Park (6-3) | 65-53 | |
| » Starters: Dutch Levsen vs Howard Ehmke | Second | 9 out |
| » Lost to Athletics (64-54), 6-4 | Shibe Park (6-4) | 65-54 | Lost 2 |
| » Starters: Joe Shaute vs Eddie Rommel | Second | 9 out |
| Sunday, August 22 |
| » Defeated Senators (59-57), 10-2 | Griffith Stadium (6-3) | 66-54 | |
| » Starters: George Uhle vs Dutch Ruether | Second | 9 out |
| » Defeated Senators (59-58), 6-0 | Griffith Stadium (7-3) | 67-54 | Won 2 |
| » Starters: Joe Shaute vs Stan Coveleski | Second | 9 out |
| Monday, August 23 |
| » Lost to Yankees (77-45), 3-2 | Yankee Stadium (3-6) | 67-55 | |
| » Starters: Dutch Levsen vs Urban Shocker | Second | 10 out |
| Wednesday, August 25 |
| » Defeated Yankees (77-46), 6-0 | Yankee Stadium (4-6) | 68-55 | |
| » Starters: George Uhle vs Sam Jones | Second | 9 out |
| Friday, August 27 |
| » Defeated Red Sox (42-85), 9-3 | Fenway Park (6-2) | 69-55 | Won 2 |
| » Starters: Joe Shaute vs Paul Zahniser | Second | 8½ out |
| » Defeated Red Sox (42-86), 5-4 | Fenway Park (7-2) | 70-55 | Won 3 |
| » Starters: Jake Miller vs Fred Heimach | Second | 8½ out |
| Saturday, August 28 |
| » Defeated Red Sox (42-87), 6-1 | Fenway Park (8-2) | 71-55 | Won 4 |
| » Starters: Dutch Levsen vs Hal Wiltse | Second | 7 out |
| » Defeated Red Sox (42-88), 5-1 | Fenway Park (9-2) | 72-55 | Won 5 |
| » Starters: Dutch Levsen vs Slim Harriss | Second | 7 out |
| Sunday, August 29 |
| » Defeated Browns (52-76), 2-1 | League Park II (35-24) | 73-55 | Won 6 |
| » Starters: Win Ballou vs George Uhle | Second | 7 out |
| Tuesday, August 31 |
| » Defeated Browns (52-77), 6-5 | League Park II (36-24) | 74-55 | Won 7 |
| » Starters: Elam Vangilder vs Joe Shaute | Second | 5½ out |
| Friday, September 3 |
| » Defeated Tigers (68-63), 9-1 | League Park II (37-24) | 75-55 | Won 8 |
| » Starters: Earl Whitehill vs George Uhle | Second | 5½ out |
| Sunday, September 5 |
| » Defeated Tigers (68-64), 8-7 | League Park II (38-24) | 76-55 | Won 9 |
| » Starters: Ed Wells vs Dutch Levsen | Second | 6 out |
| » Lost to Tigers (69-64), 2-0 | League Park II (38-25) | 76-56 | |
| » Starters: Sam Gibson vs Joe Shaute | Second | 6 out |
| Monday, September 6 |
| » Defeated Browns (53-80), 7-6 | Sportsman's Park III (4-5) | 77-56 | |
| » Starters: Dutch Levsen vs Joe Giard | Second | 6 out |
| » Lost to Browns (54-80), 3-1 | Sportsman's Park III (4-6) | 77-57 | |
| » Starters: Willis Hudlin vs Ernie Wingard | Second | 6 out |
| Tuesday, September 7 |
| » Lost to Browns (55-80), 8-3 | Sportsman's Park III (4-7) | 77-58 | Lost 2 |
| » Starters: George Uhle vs Chet Falk | Second | 7 out |
| Wednesday, September 8 |
| » Lost to Tigers (70-67), 10-7 | Tiger Stadium (4-6) | 77-59 | Lost 3 |
| » Starters: Joe Shaute vs Earl Whitehill | Second | 7 out |
| Thursday, September 9 |
| » Lost to Tigers (71-67), 3-1 | Tiger Stadium (4-7) | 77-60 | Lost 4 |
| » Starters: Garland Buckeye vs Sam Gibson | Second | 8 out |
| Saturday, September 11 |
| » Defeated Senators (72-61), 8-1 | League Park II (39-25) | 78-60 | |
| » Starters: Walter Johnson vs George Uhle | Second | 7½ out |
| » Defeated Senators (72-62), 3-2 | League Park II (40-25) | 79-60 | Won 2 |
| » Starters: Stan Coveleski vs Sherry Smith | Second | 7½ out |
| Sunday, September 12 |
| » Defeated Senators (72-63), 14-4 | League Park II (41-25) | 80-60 | Won 3 |
| » Starters: George Murray vs Dutch Levsen | Second | 7 out |
| Monday, September 13 |
| » Defeated Senators (72-64), 6-3 | League Park II (42-25) | 81-60 | Won 4 |
| » Starters: Alvin Crowder vs Joe Shaute | Second | 5½ out |
| Wednesday, September 15 |
| » Lost to Yankees (87-54), 6-4 | League Park II (42-26) | 81-61 | |
| » Starters: Sam Jones vs George Uhle | Second | 6½ out |
| Thursday, September 16 |
| » Defeated Yankees (87-55), 2-1 | League Park II (43-26) | 82-61 | |
| » Starters: Dutch Ruether vs Dutch Levsen | Second | 4½ out |
| » Defeated Yankees (87-56), 5-0 | League Park II (44-26) | 83-61 | Won 2 |
| » Starters: Herb Pennock vs Garland Buckeye | Second | 4½ out |
| Friday, September 17 |
| » Defeated Yankees (87-57), 5-1 | League Park II (45-26) | 84-61 | Won 3 |
| » Starters: Waite Hoyt vs Joe Shaute | Second | 3½ out |
| Saturday, September 18 |
| » Defeated Yankees (87-58), 3-1 | League Park II (46-26) | 85-61 | Won 4 |
| » Starters: Urban Shocker vs George Uhle | Second | 2½ out |
| Sunday, September 19 |
| » Lost to Yankees (88-58), 8-3 | League Park II (46-27) | 85-62 | |
| » Starters: Dutch Ruether vs Dutch Levsen | Second | 3½ out |
| Monday, September 20 |
| » Lost to Red Sox (46-103), 3-2 | League Park II (46-28) | 85-63 | Lost 2 |
| » Starters: Ted Wingfield vs Sherry Smith | Second | 3 out |
| Tuesday, September 21 |
| » Defeated Red Sox (46-104), 6-1 | League Park II (47-28) | 86-63 | |
| » Starters: Red Ruffing vs George Uhle | Second | 3 out |
| Wednesday, September 22 |
| » Defeated Red Sox (46-105), 5-1 | League Park II (48-28) | 87-63 | Won 2 |
| » Starters: Fred Heimach vs Garland Buckeye | Second | 2 out |
| Friday, September 24 |
| » Lost to Athletics (81-66), 3-1 | League Park II (48-29) | 87-64 | |
| » Starters: Eddie Rommel vs George Uhle | Second | 2½ out |
| Sunday, September 26 |
| » Lost to Athletics (82-66), 8-5 | League Park II (48-30) | 87-65 | Lost 2 |
| » Starters: Howard Ehmke vs Dutch Levsen | Second | 3½ out |
| » Lost to Athletics (83-66), 2-0 | League Park II (48-31) | 87-66 | Lost 3 |
| » Starters: Rube Walberg vs Garland Buckeye | Second | 3½ out |
| Monday, September 27 |
| » Defeated Athletics (83-67), 5-4 | League Park II (49-31) | 88-66 | |
| » Starters: Lefty Grove vs George Uhle | Second | 3 out |
| Monday, October 11 |
| Future Indian Joe Ginsberg is born in New York, NY. |
| Saturday, December 11 |
| Future Indian John Gray is born in West Palm Beach, FL. |
Game information provided by Retrosheet (www.retrosheet.org) |
