| Thursday, January 22 |
| Future Indian Bobby Young is born in Granite, MD. |
| Sunday, March 1 |
| Future Indian Bob Usher is born in San Diego, CA. |
| Wednesday, March 18 |
| Future Indian Fred Hatfield is born in Lanett, AL. |
| Tuesday, April 14 |
| » Defeated Browns (0-1), 21-14 | Sportsman's Park III (1-0) | 1-0 | |
| » Starters: Sherry Smith vs Bullet Joe Bush | First | -- |
| » Major-league debuts: Leo Dixon (Browns) |
| Thursday, April 16 |
| » Defeated Browns (0-2), 2-1 | Sportsman's Park III (2-0) | 2-0 | Won 2 |
| » Starters: George Uhle vs Elam Vangilder | Second | ½ out |
| Friday, April 17 |
| » Defeated Browns (0-3), 1-0 | Sportsman's Park III (3-0) | 3-0 | Won 3 |
| » Starters: Joe Shaute vs Milt Gaston | First | -- |
| Saturday, April 18 |
| » Defeated Tigers (2-3), 5-3 | Tiger Stadium (1-0) | 4-0 | Won 4 |
| » Starters: Sherry Smith vs Ed Wells | First | -- |
| Monday, April 20 |
| » Defeated Tigers (2-4), 5-4 | Tiger Stadium (2-0) | 5-0 | Won 5 |
| » Starters: George Uhle vs Dutch Leonard | First | -- |
| Tuesday, April 21 |
| » Lost to Tigers (3-4), 4-3 | Tiger Stadium (2-1) | 5-1 | |
| » Starters: Joe Shaute vs Earl Whitehill | First | -- |
| Wednesday, April 22 |
| » Lost to Browns (3-5), 3-2 | League Park II (0-1) | 5-2 | Lost 2 |
| » Starters: Bullet Joe Bush vs Sherry Smith | First | -- |
| Thursday, April 23 |
| » Defeated Browns (3-6), 14-9 | League Park II (1-1) | 6-2 | |
| » Starters: Elam Vangilder vs James Edwards | First | -- |
| Friday, April 24 |
| » Defeated Browns (3-7), 8-4 | League Park II (2-1) | 7-2 | Won 2 |
| » Starters: Dixie Davis vs George Uhle | First | -- |
| Saturday, April 25 |
| » Lost to Browns (4-7), 6-5 | League Park II (2-2) | 7-3 | |
| » Starters: Ernie Wingard vs Joe Shaute | Second | ½ out |
| Sunday, April 26 |
| » Defeated White Sox (8-5), 7-2 | Comiskey Park I (1-0) | 8-3 | |
| » Starters: Sherry Smith vs Sloppy Thurston | First | -- |
| Monday, April 27 |
| » Lost to White Sox (9-5), 12-4 | Comiskey Park I (1-1) | 8-4 | |
| » Starters: Benn Karr vs Charlie Robertson | Second | ½ out |
| Tuesday, April 28 |
| » Defeated White Sox (9-6), 3-2 | Comiskey Park I (2-1) | 9-4 | |
| » Starters: George Uhle vs Ted Blankenship | Third | ½ out |
| Friday, May 1 |
| » Defeated Tigers (4-12), 8-7 | League Park II (3-2) | 10-4 | Won 2 |
| » Starters: Ed Wells vs Joe Shaute | Second | ½ out |
| Saturday, May 2 |
| » Defeated Tigers (4-13), 8-7 | League Park II (4-2) | 11-4 | Won 3 |
| » Starters: Rip Collins vs Sherry Smith | First | -- |
| Sunday, May 3 |
| » Tied Tigers, 6-6 | League Park II (4-2) | 11-4 | |
| » Starters: Earl Whitehill vs George Uhle | First | -- |
| Tuesday, May 5 |
| » Lost to White Sox (12-7), 7-2 | League Park II (4-3) | 11-5 | |
| » Starters: Ted Blankenship vs Joe Shaute | First | -- |
| Thursday, May 7 |
| » Defeated White Sox (12-8), 7-5 | League Park II (5-3) | 12-5 | |
| » Starters: Sarge Connally vs Sherry Smith | First | -- |
| Friday, May 8 |
| » Lost to Athletics (13-5), 5-3 | League Park II (5-4) | 12-6 | |
| » Starters: Sam Gray vs George Uhle | Second | 1 out |
| Saturday, May 9 |
| » Lost to Athletics (14-5), 6-5 | League Park II (5-5) | 12-7 | Lost 2 |
| » Starters: Eddie Rommel vs Garland Buckeye | Third | 2 out |
| Monday, May 11 |
| » Lost to Athletics (15-5), 2-1 | League Park II (5-6) | 12-8 | Lost 3 |
| » Starters: Slim Harriss vs Joe Shaute | Third | 3 out |
| Tuesday, May 12 |
| » Defeated Red Sox (7-15), 9-4 | League Park II (6-6) | 13-8 | |
| » Starters: Ted Wingfield vs Sherry Smith | Third | 3 out |
| Wednesday, May 13 |
| » Defeated Red Sox (7-16), 6-4 | League Park II (7-6) | 14-8 | Won 2 |
| » Starters: Ray Francis vs George Uhle | Third | 3 out |
| Thursday, May 14 |
| » Defeated Red Sox (7-17), 4-3 | League Park II (8-6) | 15-8 | Won 3 |
| » Starters: Red Ruffing vs Benn Karr | Third | 3 out |
| Friday, May 15 |
| » Defeated Red Sox (7-18), 10-7 | League Park II (9-6) | 16-8 | Won 4 |
| » Starters: Jack Quinn vs Joe Shaute | Third | 3 out |
| Saturday, May 16 |
| » Lost to Senators (18-8), 6-2 | League Park II (9-7) | 16-9 | |
| » Starters: Walter Johnson vs Sherry Smith | Third | 3½ out |
| Sunday, May 17 |
| » Lost to Senators (19-8), 2-1 | League Park II (9-8) | 16-10 | Lost 2 |
| » Starters: Tom Zachary vs George Uhle | Third | 4½ out |
| Monday, May 18 |
| » Defeated Senators (19-9), 9-6 | League Park II (10-8) | 17-10 | |
| » Starters: George Mogridge vs Benn Karr | Third | 3½ out |
| Tuesday, May 19 |
| » Lost to Senators (20-9), 4-3 | League Park II (10-9) | 17-11 | |
| » Starters: Stan Coveleski vs Joe Shaute | Fourth | 3½ out |
| Wednesday, May 20 |
| » Defeated Yankees (10-19), 10-9 | League Park II (11-9) | 18-11 | |
| » Starters: Urban Shocker vs Sherry Smith | Fourth | 3½ out |
| Thursday, May 21 |
| » Lost to Yankees (11-19), 6-3 | League Park II (11-10) | 18-12 | |
| » Starters: Bob Shawkey vs George Uhle | Fourth | 4½ out |
| Saturday, May 23 |
| » Lost to Yankees (12-19), 7-6 | League Park II (11-11) | 18-13 | Lost 2 |
| » Starters: Waite Hoyt vs Benn Karr | Fourth | 4½ out |
| Tuesday, May 26 |
| » Lost to Browns (17-21), 8-4 | Sportsman's Park III (3-1) | 18-14 | Lost 3 |
| » Starters: Joe Shaute vs Elam Vangilder | Fourth | 5½ out |
| » Lost to Browns (18-21), 5-4 | Sportsman's Park III (3-2) | 18-15 | Lost 4 |
| » Starters: Sherry Smith vs Dave Danforth | Fourth | 5½ out |
| Wednesday, May 27 |
| » Defeated Browns (18-22), 4-2 | Sportsman's Park III (4-2) | 19-15 | |
| » Starters: George Uhle vs Ernie Wingard | Fourth | 4½ out |
| Thursday, May 28 |
| » Lost to Browns (19-22), 4-3 | Sportsman's Park III (4-3) | 19-16 | |
| » Starters: Benn Karr vs Bullet Joe Bush | Fourth | 6 out |
| Friday, May 29 |
| » Lost to Browns (20-22), 7-4 | Sportsman's Park III (4-4) | 19-17 | Lost 2 |
| » Starters: Luther Roy vs Dixie Davis | Fourth | 7 out |
| Saturday, May 30 |
| » Lost to Tigers (17-25), 12-7 | Tiger Stadium (2-2) | 19-18 | Lost 3 |
| » Starters: Sherry Smith vs Rip Collins | Fourth | 9 out |
| » Lost to Tigers (18-25), 10-2 | Tiger Stadium (2-3) | 19-19 | Lost 4 |
| » Starters: Carl Yowell vs Dutch Leonard | Fourth | 9 out |
| Sunday, May 31 |
| » Defeated Tigers (18-26), 6-4 | Tiger Stadium (3-3) | 20-19 | |
| » Starters: George Uhle vs Lil Stoner | Fourth | 8 out |
| Monday, June 1 |
| » Lost to Browns (22-24), 10-2 | League Park II (11-12) | 20-20 | |
| » Starters: Bullet Joe Bush vs Benn Karr | Fourth | 8 out |
| Tuesday, June 2 |
| » Lost to Browns (23-24), 8-3 | League Park II (11-13) | 20-21 | Lost 2 |
| » Starters: Milt Gaston vs Jake Miller | Fifth | 9 out |
| Wednesday, June 3 |
| » Lost to Browns (24-24), 7-6 | League Park II (11-14) | 20-22 | Lost 3 |
| » Starters: Dave Danforth vs Joe Shaute | Fifth | 9 out |
| Thursday, June 4 |
| » Defeated Browns (24-25), 11-10 | League Park II (12-14) | 21-22 | |
| » Starters: Ernie Wingard vs George Uhle | Fifth | 9 out |
| Future Indian Dick Aylward is born in Baltimore, MD. |
| Friday, June 5 |
| » Lost to Red Sox (17-29), 5-4 | Fenway Park (0-1) | 21-23 | |
| » Starters: Benn Karr vs Red Ruffing | Fifth | 10 out |
| Saturday, June 6 |
| » Defeated Red Sox (17-30), 8-4 | Fenway Park (1-1) | 22-23 | |
| » Starters: Jake Miller vs Jack Quinn | Fourth | 9 out |
| Monday, June 8 |
| » Lost to Red Sox (18-30), 3-1 | Fenway Park (1-2) | 22-24 | |
| » Starters: Joe Shaute vs Howard Ehmke | Fourth | 9 out |
| Tuesday, June 9 |
| » Defeated Red Sox (18-31), 3-2 | Fenway Park (2-2) | 23-24 | |
| » Starters: George Uhle vs Paul Zahniser | Fourth | 9 out |
| Wednesday, June 10 |
| » Lost to Yankees (21-28), 6-5 | Yankee Stadium (0-1) | 23-25 | |
| » Starters: Benn Karr vs Sad Sam Jones | Fifth | 10 out |
| Thursday, June 11 |
| » Defeated Yankees (21-29), 4-1 | Yankee Stadium (1-1) | 24-25 | |
| » Starters: Jake Miller vs Herb Pennock | Fifth | 9 out |
| Friday, June 12 |
| » Defeated Yankees (21-30), 5-2 | Yankee Stadium (2-1) | 25-25 | Won 2 |
| » Starters: Joe Shaute vs Bob Shawkey | Fourth | 8 out |
| Saturday, June 13 |
| » Lost to Yankees (22-30), 7-4 | Yankee Stadium (2-2) | 25-26 | |
| » Starters: George Uhle vs Waite Hoyt | Fifth | 9 out |
| Sunday, June 14 |
| » Defeated Athletics (34-18), 3-0 | League Park II (13-14) | 26-26 | |
| » Starters: Rube Walberg vs Benn Karr | Fourth | 8 out |
| Monday, June 15 |
| » Lost to Athletics (35-18), 17-15 | Shibe Park (0-1) | 26-27 | |
| » Starters: Jake Miller vs Eddie Rommel | Fourth | 9 out |
| Tuesday, June 16 |
| » Lost to Athletics (36-18), 12-7 | Shibe Park (0-2) | 26-28 | Lost 2 |
| » Starters: Joe Shaute vs Lefty Grove | Fourth | 10 out |
| Wednesday, June 17 |
| » Lost to Athletics (37-18), 10-3 | Shibe Park (0-3) | 26-29 | Lost 3 |
| » Starters: Sherry Smith vs Slim Harriss | Fourth | 11 out |
| Thursday, June 18 |
| » Lost to Athletics (38-18), 6-2 | League Park II (13-15) | 26-30 | Lost 4 |
| » Starters: Rube Walberg vs George Uhle | Fifth | 12 out |
| Friday, June 19 |
| » Lost to Senators (37-20), 7-5 | League Park II (13-16) | 26-31 | Lost 5 |
| » Starters: Vean Gregg vs Benn Karr | Fifth | 13 out |
| Saturday, June 20 |
| » Lost to Senators (38-20), 2-1 | Griffith Stadium (0-1) | 26-32 | Lost 6 |
| » Starters: Jake Miller vs Stan Coveleski | Sixth | 14 out |
| Sunday, June 21 |
| » Defeated Senators (38-21), 7-5 | Griffith Stadium (1-1) | 27-32 | |
| » Starters: Sherry Smith vs Walter Johnson | Sixth | 13½ out |
| Monday, June 22 |
| » Lost to Senators (39-21), 7-2 | Griffith Stadium (1-2) | 27-33 | |
| » Starters: George Uhle vs Tom Zachary | Sixth | 13½ out |
| Thursday, June 25 |
| » Lost to White Sox (32-29), 7-2 | Comiskey Park I (2-2) | 27-34 | Lost 2 |
| » Starters: Benn Karr vs Mike Cvengros | Sixth | 15½ out |
| Friday, June 26 |
| » Lost to White Sox (33-29), 3-1 | Comiskey Park I (2-3) | 27-35 | Lost 3 |
| » Starters: Jake Miller vs Red Faber | Sixth | 15½ out |
| Saturday, June 27 |
| » Lost to White Sox (34-29), 2-1 | Comiskey Park I (2-4) | 27-36 | Lost 4 |
| » Starters: Sherry Smith vs Ted Lyons | Seventh | 17 out |
| » Lost to White Sox (35-29), 3-1 | Comiskey Park I (2-5) | 27-37 | Lost 5 |
| » Starters: James Edwards vs Charlie Robertson | Seventh | 17 out |
| Sunday, June 28 |
| » Lost to White Sox (36-29), 8-4 | Comiskey Park I (2-6) | 27-38 | Lost 6 |
| » Starters: George Uhle vs Sloppy Thurston | Seventh | 17 out |
| Monday, June 29 |
| » Lost to Tigers (33-34), 4-1 | League Park II (13-17) | 27-39 | Lost 7 |
| » Starters: Hooks Dauss vs Carl Yowell | Seventh | 17½ out |
| » Lost to Tigers (34-34), 7-4 | League Park II (13-18) | 27-40 | Lost 8 |
| » Starters: Dutch Leonard vs Benn Karr | Seventh | 17½ out |
| Tuesday, June 30 |
| » Defeated Tigers (34-35), 6-3 | League Park II (14-18) | 28-40 | |
| » Starters: Earl Whitehill vs Jake Miller | Seventh | 17 out |
| Wednesday, July 1 |
| » Defeated Tigers (34-36), 11-0 | League Park II (15-18) | 29-40 | Won 2 |
| » Starters: Ed Wells vs Sherry Smith | Seventh | 17 out |
| » Lost to Tigers (35-36), 4-1 | League Park II (15-19) | 29-41 | |
| » Starters: Lil Stoner vs James Edwards | Seventh | 17 out |
| Thursday, July 2 |
| » Defeated Tigers (35-37), 11-3 | League Park II (16-19) | 30-41 | |
| » Starters: Ownie Carroll vs Garland Buckeye | Seventh | 17½ out |
| Friday, July 3 |
| » Lost to White Sox (38-32), 10-5 | League Park II (16-20) | 30-42 | |
| » Starters: Ted Lyons vs Benn Karr | Seventh | 18½ out |
| Saturday, July 4 |
| » Lost to White Sox (39-32), 14-5 | League Park II (16-21) | 30-43 | Lost 2 |
| » Starters: Mike Cvengros vs Bert Cole | Seventh | 18½ out |
| » Defeated White Sox (39-33), 5-4 | League Park II (17-21) | 31-43 | |
| » Starters: Red Faber vs Jake Miller | Seventh | 18½ out |
| Sunday, July 5 |
| » Lost to White Sox (40-33), 5-4 | League Park II (17-22) | 31-44 | |
| » Starters: Sloppy Thurston vs Sherry Smith | Seventh | 19½ out |
| Monday, July 6 |
| » Defeated White Sox (40-34), 3-1 | League Park II (18-22) | 32-44 | |
| » Starters: Charlie Robertson vs Garland Buckeye | Seventh | 18½ out |
| » Defeated White Sox (40-35), 4-3 | League Park II (19-22) | 33-44 | Won 2 |
| » Starters: Mike Cvengros vs Joe Shaute | Seventh | 18½ out |
| Wednesday, July 8 |
| » Defeated Athletics (46-26), 14-3 | League Park II (20-22) | 34-44 | Won 3 |
| » Starters: Rube Walberg vs Benn Karr | Seventh | 18½ out |
| » Lost to Athletics (47-26), 7-5 | League Park II (20-23) | 34-45 | |
| » Starters: Eddie Rommel vs George Uhle | Seventh | 18½ out |
| Thursday, July 9 |
| » Defeated Athletics (47-27), 13-11 | League Park II (21-23) | 35-45 | |
| » Starters: Slim Harriss vs Jake Miller | Sixth | 18½ out |
| Friday, July 10 |
| » Defeated Athletics (47-28), 6-1 | League Park II (22-23) | 36-45 | Won 2 |
| » Starters: Lefty Grove vs Garland Buckeye | Sixth | 17½ out |
| Saturday, July 11 |
| » Lost to Red Sox (25-54), 14-7 | League Park II (22-24) | 36-46 | |
| » Starters: Red Ruffing vs Joe Shaute | Sixth | 17½ out |
| Sunday, July 12 |
| » Defeated Red Sox (25-55), 13-2 | League Park II (23-24) | 37-46 | |
| » Starters: Howard Ehmke vs Benn Karr | Sixth | 17½ out |
| Monday, July 13 |
| » Lost to Red Sox (26-55), 12-11 | League Park II (23-25) | 37-47 | |
| » Starters: Oscar Fuhr vs Sherry Smith | Sixth | 17½ out |
| Tuesday, July 14 |
| » Defeated Red Sox (26-56), 6-1 | League Park II (24-25) | 38-47 | |
| » Starters: Paul Zahniser vs Garland Buckeye | Sixth | 16½ out |
| Wednesday, July 15 |
| » Defeated Yankees (34-49), 5-4 | League Park II (25-25) | 39-47 | Won 2 |
| » Starters: Bob Shawkey vs Bert Cole | Sixth | 16 out |
| » Lost to Yankees (35-49), 9-4 | League Park II (25-26) | 39-48 | |
| » Starters: Herb Pennock vs Jake Miller | Sixth | 16 out |
| Thursday, July 16 |
| » Defeated Yankees (35-50), 17-9 | League Park II (26-26) | 40-48 | |
| » Starters: Sad Sam Jones vs Joe Shaute | Sixth | 16 out |
| Friday, July 17 |
| » Lost to Yankees (36-50), 5-1 | League Park II (26-27) | 40-49 | |
| » Starters: Waite Hoyt vs Sherry Smith | Sixth | 17 out |
| Saturday, July 18 |
| » Lost to Senators (55-31), 19-6 | League Park II (26-28) | 40-50 | Lost 2 |
| » Starters: Vean Gregg vs Garland Buckeye | Sixth | 17 out |
| Sunday, July 19 |
| » Lost to Senators (56-31), 4-2 | League Park II (26-29) | 40-51 | Lost 3 |
| » Starters: Dutch Ruether vs Benn Karr | Sixth | 18 out |
| Monday, July 20 |
| » Lost to Senators (57-31), 9-1 | League Park II (26-30) | 40-52 | Lost 4 |
| » Starters: Stan Coveleski vs Jake Miller | Fifth | 19 out |
| Thursday, July 23 |
| » Defeated Browns (48-45), 10-1 | Sportsman's Park III (5-4) | 41-52 | |
| » Starters: Sherry Smith vs Milt Gaston | Sixth | 18½ out |
| Saturday, July 25 |
| » Defeated Browns (48-46), 12-7 | Sportsman's Park III (6-4) | 42-52 | Won 2 |
| » Starters: Garland Buckeye vs Dave Danforth | Fifth | 19 out |
| Sunday, July 26 |
| » Defeated Browns (48-47), 11-6 | Sportsman's Park III (7-4) | 43-52 | Won 3 |
| » Starters: Benn Karr vs Bullet Joe Bush | Fifth | 18½ out |
| Tuesday, July 28 |
| » Defeated Red Sox (28-67), 16-7 | Fenway Park (3-2) | 44-52 | Won 4 |
| » Starters: Sherry Smith vs Red Ruffing | Sixth | 18 out |
| » Major-league debuts: Jack Rothrock (Red Sox) |
| Wednesday, July 29 |
| » Defeated Red Sox (28-68), 10-5 | Fenway Park (4-2) | 45-52 | Won 5 |
| » Starters: Jake Miller vs Howard Ehmke | Sixth | 18 out |
| Thursday, July 30 |
| » Defeated Red Sox (28-69), 7-2 | Fenway Park (5-2) | 46-52 | Won 6 |
| » Starters: Garland Buckeye vs Paul Zahniser | Sixth | 18 out |
| Future Indian Bill Glynn is born in Sussex, NJ. |
| Friday, July 31 |
| » Lost to Red Sox (29-69), 7-2 | Fenway Park (5-3) | 46-53 | |
| » Starters: Benn Karr vs Ted Wingfield | Sixth | 18½ out |
| Saturday, August 1 |
| » Lost to Yankees (42-55), 8-3 | Yankee Stadium (2-3) | 46-54 | Lost 2 |
| » Starters: Sherry Smith vs Herb Pennock | Fifth | 18½ out |
| Sunday, August 2 |
| » Defeated Yankees (42-56), 3-2 | Yankee Stadium (3-3) | 47-54 | |
| » Starters: Jake Miller vs Bob Shawkey | Sixth | 18 out |
| Monday, August 3 |
| » Lost to Yankees (43-56), 3-2 | Yankee Stadium (3-4) | 47-55 | |
| » Starters: Garland Buckeye vs Sad Sam Jones | Sixth | 19 out |
| Future Indian Dave Hoskins is born in Greenwood, MS. |
| Tuesday, August 4 |
| » Lost to Yankees (44-56), 4-1 | Yankee Stadium (3-5) | 47-56 | Lost 2 |
| » Starters: Benn Karr vs Urban Shocker | Sixth | 20 out |
| Thursday, August 6 |
| » Defeated Athletics (64-34), 9-6 | Shibe Park (1-3) | 48-56 | |
| » Starters: Sherry Smith vs Slim Harriss | Sixth | 20 out |
| » Lost to Athletics (65-34), 6-1 | Shibe Park (1-4) | 48-57 | |
| » Starters: Jake Miller vs Rube Walberg | Sixth | 20 out |
| Friday, August 7 |
| » Defeated Athletics (65-35), 10-4 | Shibe Park (2-4) | 49-57 | |
| » Starters: Garland Buckeye vs Jack Quinn | Sixth | 20 out |
| » Lost to Athletics (66-35), 2-0 | Shibe Park (2-5) | 49-58 | |
| » Starters: George Uhle vs Eddie Rommel | Sixth | 20 out |
| Saturday, August 8 |
| » Lost to Athletics (67-35), 10-4 | Shibe Park (2-6) | 49-59 | Lost 2 |
| » Starters: Benn Karr vs Sam Gray | Sixth | 21 out |
| Sunday, August 9 |
| » Defeated Senators (66-38), 7-6 | Griffith Stadium (2-2) | 50-59 | |
| » Starters: Sherry Smith vs Walter Johnson | Sixth | 20½ out |
| Monday, August 10 |
| » Lost to Senators (67-38), 3-2 | Griffith Stadium (2-3) | 50-60 | |
| » Starters: Jake Miller vs Dutch Ruether | Sixth | 21½ out |
| Tuesday, August 11 |
| » Lost to Senators (68-38), 3-1 | Griffith Stadium (2-4) | 50-61 | Lost 2 |
| » Starters: Garland Buckeye vs Stan Coveleski | Sixth | 22½ out |
| Thursday, August 13 |
| » Defeated Senators (68-39), 2-0 | Griffith Stadium (3-4) | 51-61 | |
| » Starters: George Uhle vs Tom Zachary | Sixth | 22½ out |
| » Lost to Senators (69-39), 5-4 | Griffith Stadium (3-5) | 51-62 | |
| » Starters: Benn Karr vs Walter Johnson | Sixth | 22½ out |
| Friday, August 14 |
| » Lost to Browns (54-56), 10-7 | League Park II (26-31) | 51-63 | Lost 2 |
| » Starters: Ernie Wingard vs Sherry Smith | Sixth | 23½ out |
| Saturday, August 15 |
| » Lost to Browns (55-56), 3-0 | League Park II (26-32) | 51-64 | Lost 3 |
| » Starters: Joe Giard vs Jake Miller | Sixth | 24 out |
| Sunday, August 16 |
| » Defeated Browns (55-57), 7-6 | League Park II (27-32) | 52-64 | |
| » Starters: Elam Vangilder vs Garland Buckeye | Sixth | 23½ out |
| Future Indian Willie Jones is born in Dillon, SC. |
| Tuesday, August 18 |
| » Lost to Senators (72-40), 7-4 | League Park II (27-33) | 52-65 | |
| » Starters: Walter Johnson vs George Uhle | Sixth | 23½ out |
| Wednesday, August 19 |
| » Lost to Senators (73-40), 12-8 | League Park II (27-34) | 52-66 | Lost 2 |
| » Starters: Dutch Ruether vs Sherry Smith | Sixth | 23½ out |
| » Major-league debuts: Johnny Hodapp (Indians) |
| Thursday, August 20 |
| » Lost to Senators (74-40), 1-0 | League Park II (27-35) | 52-67 | Lost 3 |
| » Starters: Tom Zachary vs Jake Miller | Sixth | 24½ out |
| Friday, August 21 |
| » Defeated Yankees (48-65), 2-1 | League Park II (28-35) | 53-67 | |
| » Starters: Sad Sam Jones vs Garland Buckeye | Sixth | 23½ out |
| Saturday, August 22 |
| » Defeated Yankees (48-66), 5-4 | League Park II (29-35) | 54-67 | Won 2 |
| » Starters: Bob Shawkey vs George Uhle | Sixth | 23½ out |
| Sunday, August 23 |
| » Defeated Yankees (48-67), 7-6 | League Park II (30-35) | 55-67 | Won 3 |
| » Starters: Urban Shocker vs Benn Karr | Sixth | 23½ out |
| Monday, August 24 |
| » Defeated Yankees (48-68), 5-1 | League Park II (31-35) | 56-67 | Won 4 |
| » Starters: Waite Hoyt vs Jake Miller | Sixth | 22½ out |
| Tuesday, August 25 |
| » Defeated Athletics (74-43), 4-3 | League Park II (32-35) | 57-67 | Won 5 |
| » Starters: Rube Walberg vs Garland Buckeye | Sixth | 21½ out |
| Wednesday, August 26 |
| » Defeated Athletics (74-44), 8-1 | League Park II (33-35) | 58-67 | Won 6 |
| » Starters: Slim Harriss vs George Uhle | Sixth | 20½ out |
| Friday, August 28 |
| » Lost to Red Sox (36-86), 2-1 | League Park II (33-36) | 58-68 | |
| » Starters: Paul Zahniser vs Jake Miller | Sixth | 21 out |
| Saturday, August 29 |
| » Defeated Red Sox (36-87), 3-2 | League Park II (34-36) | 59-68 | |
| » Starters: Red Ruffing vs By Speece | Sixth | 21 out |
| Sunday, August 30 |
| » Defeated Red Sox (36-88), 2-1 | League Park II (35-36) | 60-68 | Won 2 |
| » Starters: Ted Wingfield vs Sherry Smith | Sixth | 21 out |
| Thursday, September 3 |
| » Lost to Tigers (65-60), 11-9 | League Park II (35-37) | 60-69 | |
| » Starters: Earl Whitehill vs George Uhle | Sixth | 22½ out |
| Saturday, September 5 |
| » Lost to Tigers (66-60), 6-4 | League Park II (35-38) | 60-70 | Lost 2 |
| » Starters: Hooks Dauss vs Garland Buckeye | Sixth | 24 out |
| Monday, September 7 |
| » Defeated White Sox (69-61), 6-5 | League Park II (36-38) | 61-70 | |
| » Starters: Ted Blankenship vs Jake Miller | Sixth | 24½ out |
| » Lost to White Sox (70-61), 5-0 | League Park II (36-39) | 61-71 | |
| » Starters: James Edwards vs Sherry Smith | Sixth | 24½ out |
| Tuesday, September 8 |
| » Defeated White Sox (70-62), 4-2 | League Park II (37-39) | 62-71 | |
| » Starters: Charlie Robertson vs George Uhle | Sixth | 23½ out |
| Thursday, September 10 |
| » Lost to Tigers (69-61), 6-1 | Tiger Stadium (3-4) | 62-72 | |
| » Starters: Jake Miller vs Hooks Dauss | Sixth | 23 out |
| » Defeated Tigers (69-62), 7-2 | Tiger Stadium (4-4) | 63-72 | |
| » Starters: Garland Buckeye vs Ed Wells | Sixth | 23 out |
| Friday, September 11 |
| » Lost to Tigers (70-62), 5-4 | Tiger Stadium (4-5) | 63-73 | |
| » Starters: Sherry Smith vs Ken Holloway | Sixth | 24 out |
| Saturday, September 12 |
| » Defeated Tigers (70-63), 4-1 | Tiger Stadium (5-5) | 64-73 | |
| » Starters: Benn Karr vs Earl Whitehill | Sixth | 24½ out |
| » Lost to Tigers (71-63), 3-2 | Tiger Stadium (5-6) | 64-74 | |
| » Starters: By Speece vs Lil Stoner | Sixth | 24½ out |
| Sunday, September 13 |
| » Defeated Tigers (71-64), 8-6 | Tiger Stadium (6-6) | 65-74 | |
| » Starters: George Uhle vs Rip Collins | Sixth | 24 out |
| Monday, September 14 |
| » Major-league debuts: Charlie Engle (Athletics) |
| Tuesday, September 15 |
| » Major-league debuts: Tom Jenkins (Red Sox) |
| Wednesday, September 16 |
| » Lost to Yankees (60-78), 8-0 | Yankee Stadium (3-6) | 65-75 | |
| » Starters: Garland Buckeye vs Urban Shocker | Sixth | 25½ out |
| » Lost to Yankees (61-78), 4-3 | Yankee Stadium (3-7) | 65-76 | Lost 2 |
| » Starters: By Speece vs Herb Pennock | Sixth | 25½ out |
| Thursday, September 17 |
| » Lost to Yankees (62-78), 5-0 | Yankee Stadium (3-8) | 65-77 | Lost 3 |
| » Starters: Sherry Smith vs Hank Johnson | Sixth | 26 out |
| Friday, September 18 |
| » Defeated Red Sox (42-98), 6-5 | Fenway Park (6-3) | 66-77 | |
| » Starters: Benn Karr vs Buster Ross | Sixth | 26 out |
| Saturday, September 19 |
| » Lost to Red Sox (43-98), 3-2 | Fenway Park (6-4) | 66-78 | |
| » Starters: Jake Miller vs Howard Ehmke | Sixth | 26 out |
| » Defeated Red Sox (43-99), 5-0 | Fenway Park (7-4) | 67-78 | |
| » Starters: Garland Buckeye vs Joe Kiefer | Sixth | 26 out |
| Tuesday, September 22 |
| » Lost to Senators (93-50), 3-2 | Griffith Stadium (3-6) | 67-79 | |
| » Starters: Dutch Levsen vs Stan Coveleski | Sixth | 27½ out |
| Thursday, September 24 |
| » Lost to Senators (94-50), 4-3 | Griffith Stadium (3-7) | 67-80 | Lost 2 |
| » Starters: Sherry Smith vs Dutch Ruether | Sixth | 29½ out |
| » Lost to Senators (95-50), 6-2 | Griffith Stadium (3-8) | 67-81 | Lost 3 |
| » Starters: Joe Shaute vs Alex Ferguson | Sixth | 29½ out |
| Friday, September 25 |
| » Defeated Athletics (87-61), 9-5 | Shibe Park (3-6) | 68-81 | |
| » Starters: Carl Yowell vs Rube Walberg | Sixth | 28½ out |
| Saturday, September 26 |
| » Defeated Athletics (87-62), 7-2 | Shibe Park (4-6) | 69-81 | Won 2 |
| » Starters: Dutch Levsen vs Eddie Rommel | Sixth | 27 out |
| » Defeated Athletics (87-63), 6-0 | Shibe Park (5-6) | 70-81 | Won 3 |
| » Starters: Ray Benge vs Sam Gray | Sixth | 27 out |
| » Major-league debuts: Ray Benge (Indians) |
| Thursday, October 1 |
| » Lost to White Sox (77-75), 3-0 | Comiskey Park I (2-7) | 70-82 | |
| » Starters: Carl Yowell vs Ted Blankenship | Sixth | 27 out |
| Saturday, October 3 |
| » Lost to White Sox (78-75), 9-2 | Comiskey Park I (2-8) | 70-83 | Lost 2 |
| » Starters: Dutch Levsen vs Ted Lyons | Sixth | 27 out |
| Sunday, October 4 |
| » Lost to White Sox (79-75), 10-8 | Comiskey Park I (2-9) | 70-84 | Lost 3 |
| » Starters: Ray Benge vs Red Faber | Sixth | 27½ out |
| Tuesday, December 1 |
| Future Indian Cal McLish is born in Anadarko, OK. |
| Thursday, December 3 |
| Future Indian Harry Simpson is born in Atlanta, GA. |
| Monday, December 14 |
| Future Indian Sam Jones is born in Stewartsville, OH. |
Game information provided by Retrosheet (www.retrosheet.org) |