| Sunday, January 21 |
| Future Indian Sam Mele is born in Astoria, NY. |
| Saturday, March 17 |
| Future Indian Pat Seerey is born in Wilburton, OK. |
| Friday, April 13 |
| Former Indian Gene Krapp dies in Detroit, MI at the age of 36. |
| Wednesday, April 18 |
| » Defeated White Sox (0-1), 6-5 | League Park II (1-0) | 1-0 | |
| » Starters: Red Faber vs Stan Coveleski | First | -- |
| » Major-league debuts: Rube Lutzke (Indians) Willie Kamm (White Sox) |
| Thursday, April 19 |
| » Defeated White Sox (0-2), 6-5 | League Park II (2-0) | 2-0 | Won 2 |
| » Starters: Dixie Leverett vs Jim Joe Edwards | First | -- |
| » Major-league debuts: Roy Elsh (White Sox) |
| Friday, April 20 |
| » Defeated White Sox (0-3), 8-5 | League Park II (3-0) | 3-0 | Won 3 |
| » Starters: Ted Blankenship vs Dewey Metivier | First | -- |
| Saturday, April 21 |
| » Defeated White Sox (0-4), 5-1 | League Park II (4-0) | 4-0 | Won 4 |
| » Starters: Charlie Robertson vs George Uhle | First | -- |
| » Major-league debuts: Mudcat Grant (Indians) |
| Sunday, April 22 |
| » Defeated Tigers (3-2), 1-0 | League Park II (5-0) | 5-0 | Won 5 |
| » Starters: Rip Collins vs Stan Coveleski | First | -- |
| Monday, April 23 |
| » Defeated Tigers (3-3), 3-2 | League Park II (6-0) | 6-0 | Won 6 |
| » Starters: Ken Holloway vs Jim Joe Edwards | First | -- |
| Tuesday, April 24 |
| » Lost to Tigers (4-3), 8-7 | League Park II (6-1) | 6-1 | |
| » Starters: Herman Pillette vs Dewey Metivier | First | -- |
| Wednesday, April 25 |
| » Lost to Tigers (5-3), 2-1 | League Park II (6-2) | 6-2 | Lost 2 |
| » Starters: Hooks Dauss vs George Uhle | First | -- |
| Thursday, April 26 |
| » Defeated White Sox (1-6), 3-0 | Comiskey Park I (1-0) | 7-2 | |
| » Starters: Stan Coveleski vs Red Faber | First | -- |
| Friday, April 27 |
| » Defeated White Sox (1-7), 8-6 | Comiskey Park I (2-0) | 8-2 | Won 2 |
| » Starters: Jim Joe Edwards vs Mike Cvengros | First | -- |
| Saturday, April 28 |
| » Lost to White Sox (2-7), 6-3 | Comiskey Park I (2-1) | 8-3 | |
| » Starters: Dan Boone vs Charlie Robertson | First | -- |
| Sunday, April 29 |
| » Defeated White Sox (2-8), 8-3 | Comiskey Park I (3-1) | 9-3 | |
| » Starters: George Uhle vs Frank Woodward | First | -- |
| Monday, April 30 |
| » Defeated Tigers (8-5), 4-2 | Tiger Stadium (1-0) | 10-3 | Won 2 |
| » Starters: Stan Coveleski vs Rip Collins | First | -- |
| Tuesday, May 1 |
| » Lost to Tigers (9-5), 6-5 | Tiger Stadium (1-1) | 10-4 | |
| » Starters: Jim Joe Edwards vs Ray Francis | First | -- |
| » Major-league debuts: John Kerr (Tigers) |
| Wednesday, May 2 |
| » Lost to Tigers (10-5), 4-3 | Tiger Stadium (1-2) | 10-5 | Lost 2 |
| » Starters: Guy Morton vs Herman Pillette | First | -- |
| Thursday, May 3 |
| » Lost to Tigers (11-5), 6-5 | Tiger Stadium (1-3) | 10-6 | Lost 3 |
| » Starters: George Uhle vs Hooks Dauss | Third | 1 out |
| Friday, May 4 |
| » Lost to Browns (6-9), 9-5 | League Park II (6-3) | 10-7 | Lost 4 |
| » Starters: Urban Shocker vs Stan Coveleski | Third | 1 out |
| Saturday, May 5 |
| » Defeated Browns (6-10), 10-2 | League Park II (7-3) | 11-7 | |
| » Starters: Ray Kolp vs Jim Joe Edwards | Second | ½ out |
| Sunday, May 6 |
| » Lost to Browns (7-10), 5-4 | League Park II (7-4) | 11-8 | |
| » Starters: Elam Vangilder vs Guy Morton | Second | ½ out |
| Monday, May 7 |
| » Defeated Browns (7-11), 12-3 | League Park II (8-4) | 12-8 | |
| » Starters: Ray Kolp vs George Uhle | Second | 1 out |
| Tuesday, May 8 |
| » Lost to Yankees (12-7), 3-2 | League Park II (8-5) | 12-9 | |
| » Starters: Bob Shawkey vs Stan Coveleski | Second | 1 out |
| Thursday, May 10 |
| » Lost to Yankees (13-7), 13-4 | League Park II (8-6) | 12-10 | Lost 2 |
| » Starters: Herb Pennock vs Jim Joe Edwards | Fourth | 2 out |
| Sunday, May 13 |
| » Defeated Senators (9-11), 5-2 | League Park II (9-6) | 13-10 | |
| » Starters: Cy Warmoth vs Stan Coveleski | Second | 1½ out |
| Monday, May 14 |
| » Defeated Senators (9-12), 6-3 | League Park II (10-6) | 14-10 | Won 2 |
| » Starters: Walter Johnson vs George Uhle | Second | 1½ out |
| Tuesday, May 15 |
| » Defeated Senators (9-13), 10-9 | League Park II (11-6) | 15-10 | Won 3 |
| » Starters: George Mogridge vs Jim Joe Edwards | Second | 1½ out |
| Wednesday, May 16 |
| » Lost to Athletics (13-10), 5-0 | League Park II (11-7) | 15-11 | |
| » Starters: Eddie Rommel vs Stan Coveleski | Second | 2½ out |
| Thursday, May 17 |
| » Lost to Athletics (14-10), 4-2 | League Park II (11-8) | 15-12 | Lost 2 |
| » Starters: Fred Heimach vs George Uhle | Third | 3½ out |
| Friday, May 18 |
| » Lost to Athletics (15-10), 4-1 | League Park II (11-9) | 15-13 | Lost 3 |
| » Starters: Slim Harriss vs Joe Shaute | Third | 4½ out |
| Saturday, May 19 |
| » Lost to Athletics (16-10), 5-2 | League Park II (11-10) | 15-14 | Lost 4 |
| » Starters: Eddie Rommel vs Dewey Metivier | Third | 5½ out |
| Sunday, May 20 |
| » Defeated Red Sox (8-16), 1-0 | League Park II (12-10) | 16-14 | |
| » Starters: Jack Quinn vs Stan Coveleski | Third | 5½ out |
| Tuesday, May 22 |
| » Defeated Red Sox (8-17), 3-2 | League Park II (13-10) | 17-14 | Won 2 |
| » Starters: Howard Ehmke vs George Uhle | Third | 6 out |
| Wednesday, May 23 |
| » Lost to Red Sox (9-17), 8-6 | League Park II (13-11) | 17-15 | |
| » Starters: George Murray vs Joe Shaute | Third | 6½ out |
| Thursday, May 24 |
| » Defeated Browns (13-18), 6-1 | Sportsman's Park III (1-0) | 18-15 | |
| » Starters: Stan Coveleski vs Urban Shocker | Third | 5½ out |
| Saturday, May 26 |
| » Lost to Browns (14-18), 1-0 | Sportsman's Park III (1-1) | 18-16 | |
| » Starters: George Uhle vs Elam Vangilder | Third | 6 out |
| Sunday, May 27 |
| » Defeated Browns (14-19), 6-2 | Sportsman's Park III (2-1) | 19-16 | |
| » Starters: Joe Shaute vs Hub Pruett | Third | 6 out |
| Monday, May 28 |
| Future Indian Bob Kuzava is born in Wyandotte, MI. |
| Tuesday, May 29 |
| » Defeated White Sox (13-20), 6-4 | Comiskey Park I (4-1) | 20-16 | Won 2 |
| » Starters: Stan Coveleski vs Charlie Robertson | Third | 6 out |
| Wednesday, May 30 |
| » Defeated White Sox (13-21), 7-6 | Comiskey Park I (5-1) | 21-16 | Won 3 |
| » Starters: Joe Shaute vs Red Faber | Third | 7 out |
| » Lost to White Sox (14-21), 7-2 | Comiskey Park I (5-2) | 21-17 | |
| » Starters: George Uhle vs Dixie Leverett | Third | 7 out |
| Thursday, May 31 |
| » Defeated White Sox (14-22), 5-4 | Comiskey Park I (6-2) | 22-17 | |
| » Starters: Dewey Metivier vs Sloppy Thurston | Second | 7 out |
| Friday, June 1 |
| » Defeated Tigers (19-22), 17-4 | Tiger Stadium (2-3) | 23-17 | Won 2 |
| » Starters: George Uhle vs Ken Holloway | Third | 6 out |
| Saturday, June 2 |
| » Lost to Tigers (20-22), 9-1 | Tiger Stadium (2-4) | 23-18 | |
| » Starters: Stan Coveleski vs Herman Pillette | Third | 6 out |
| Sunday, June 3 |
| » Lost to Tigers (21-22), 8-7 | Tiger Stadium (2-5) | 23-19 | Lost 2 |
| » Starters: Joe Shaute vs Hooks Dauss | Third | 6½ out |
| Monday, June 4 |
| » Defeated Red Sox (15-22), 6-5 | Fenway Park (1-0) | 24-19 | |
| » Starters: Guy Morton vs Alex Ferguson | Third | 5½ out |
| Tuesday, June 5 |
| » Lost to Red Sox (16-22), 10-6 | Fenway Park (1-1) | 24-20 | |
| » Starters: George Uhle vs Jack Quinn | Third | 6½ out |
| Wednesday, June 6 |
| » Defeated Red Sox (16-23), 17-4 | Fenway Park (2-1) | 25-20 | |
| » Starters: Stan Coveleski vs Curt Fullerton | Third | 5½ out |
| Thursday, June 7 |
| » Lost to Red Sox (17-23), 7-1 | Fenway Park (2-2) | 25-21 | |
| » Starters: Joe Shaute vs Howard Ehmke | Third | 6 out |
| Saturday, June 9 |
| » Defeated Yankees (30-16), 13-3 | Yankee Stadium (1-0) | 26-21 | |
| » Starters: George Uhle vs Joe Bush | Third | 4½ out |
| » Major-league debuts: George Pipgras (Yankees) |
| Sunday, June 10 |
| » Lost to Yankees (31-16), 8-7 | Yankee Stadium (1-1) | 26-22 | |
| » Starters: Stan Coveleski vs Waite Hoyt | Third | 5½ out |
| Monday, June 11 |
| » Defeated Yankees (31-17), 4-3 | Yankee Stadium (2-1) | 27-22 | |
| » Starters: Sherry Smith vs Herb Pennock | Third | 4½ out |
| Tuesday, June 12 |
| » Defeated Yankees (31-18), 8-4 | Yankee Stadium (3-1) | 28-22 | Won 2 |
| » Starters: George Uhle vs Bob Shawkey | Third | 3½ out |
| Thursday, June 14 |
| » Lost to Athletics (29-20), 4-3 | Shibe Park (0-1) | 28-23 | |
| » Starters: Stan Coveleski vs Fred Heimach | Third | 4 out |
| Friday, June 15 |
| » Defeated Athletics (29-21), 4-1 | Shibe Park (1-1) | 29-23 | |
| » Starters: Sherry Smith vs Slim Harriss | Third | 4 out |
| Saturday, June 16 |
| » Defeated Athletics (29-22), 8-0 | Shibe Park (2-1) | 30-23 | Won 2 |
| » Starters: Guy Morton vs Eddie Rommel | Third | 4 out |
| Future Indian Allie Clark is born in South Amboy, NJ. |
| Sunday, June 17 |
| » Lost to Athletics (30-22), 6-4 | League Park II (13-12) | 30-24 | |
| » Starters: Bob Hasty vs George Uhle | Third | 5 out |
| Monday, June 18 |
| » Lost to Senators (23-30), 4-3 | Griffith Stadium (0-1) | 30-25 | Lost 2 |
| » Starters: Stan Coveleski vs Walter Johnson | Third | 5 out |
| Tuesday, June 19 |
| » Lost to Senators (24-30), 7-6 | Griffith Stadium (0-2) | 30-26 | Lost 3 |
| » Starters: Sherry Smith vs Cy Warmoth | Third | 6 out |
| Wednesday, June 20 |
| » Defeated Senators (24-31), 5-1 | Griffith Stadium (1-2) | 31-26 | |
| » Starters: Guy Morton vs George Mogridge | Third | 5 out |
| Thursday, June 21 |
| » Lost to Senators (25-31), 6-5 | Griffith Stadium (1-3) | 31-27 | |
| » Starters: George Uhle vs Skipper Friday | Third | 5½ out |
| Saturday, June 23 |
| » Lost to Browns (28-29), 8-2 | League Park II (13-13) | 31-28 | Lost 2 |
| » Starters: Urban Shocker vs Stan Coveleski | Third | 7 out |
| Sunday, June 24 |
| » Defeated Browns (28-30), 8-2 | League Park II (14-13) | 32-28 | |
| » Starters: Elam Vangilder vs Sherry Smith | Third | 6½ out |
| Monday, June 25 |
| » Lost to Browns (29-30), 9-4 | League Park II (14-14) | 32-29 | |
| » Starters: Dave Danforth vs Guy Morton | Third | 7½ out |
| Tuesday, June 26 |
| » Defeated Browns (29-31), 9-1 | League Park II (15-14) | 33-29 | |
| » Starters: Dixie Davis vs George Uhle | Third | 6½ out |
| Friday, June 29 |
| » Lost to White Sox (27-31), 5-4 | League Park II (15-15) | 33-30 | |
| » Starters: Mike Cvengros vs Stan Coveleski | Third | 8 out |
| Saturday, June 30 |
| » Lost to White Sox (28-31), 3-1 | League Park II (15-16) | 33-31 | Lost 2 |
| » Starters: Red Faber vs Guy Morton | Third | 9½ out |
| » Lost to White Sox (29-31), 5-4 | League Park II (15-17) | 33-32 | Lost 3 |
| » Starters: Ted Blankenship vs George Uhle | Third | 9½ out |
| Sunday, July 1 |
| » Lost to White Sox (30-31), 6-2 | League Park II (15-18) | 33-33 | Lost 4 |
| » Starters: Mike Cvengros vs Jim Joe Edwards | Third | 10½ out |
| Tuesday, July 3 |
| » Lost to Tigers (32-34), 12-8 | League Park II (15-19) | 33-34 | Lost 5 |
| » Starters: Herman Pillette vs Stan Coveleski | Third | 12 out |
| Wednesday, July 4 |
| » Defeated Tigers (32-35), 10-7 | League Park II (16-19) | 34-34 | |
| » Starters: Hooks Dauss vs Guy Morton | Fourth | 13 out |
| » Lost to Tigers (33-35), 15-3 | League Park II (16-20) | 34-35 | |
| » Starters: Bert Cole vs George Uhle | Fourth | 13 out |
| Thursday, July 5 |
| » Defeated Tigers (33-36), 10-0 | League Park II (17-20) | 35-35 | |
| » Starters: Ken Holloway vs Sherry Smith | Fourth | 12½ out |
| Friday, July 6 |
| » Defeated Red Sox (26-38), 5-3 | League Park II (18-20) | 36-35 | Won 2 |
| » Starters: Howard Ehmke vs George Uhle | Second | 12½ out |
| Saturday, July 7 |
| » Defeated Red Sox (26-39), 27-3 | League Park II (19-20) | 37-35 | Won 3 |
| » Starters: Curt Fullerton vs Stan Coveleski | Second | 11 out |
| » Defeated Red Sox (26-40), 8-5 | League Park II (20-20) | 38-35 | Won 4 |
| » Starters: George Murray vs Phil Bedgood | Second | 11 out |
| Sunday, July 8 |
| » Defeated Red Sox (26-41), 15-10 | League Park II (21-20) | 39-35 | Won 5 |
| » Starters: Alex Ferguson vs Joe Shaute | Second | 11 out |
| Monday, July 9 |
| » Lost to Red Sox (27-41), 4-1 | League Park II (21-21) | 39-36 | |
| » Starters: Bill Piercy vs Sherry Smith | Second | 12 out |
| Tuesday, July 10 |
| » Defeated Athletics (37-37), 4-3 | League Park II (22-21) | 40-36 | |
| » Starters: Fred Heimach vs George Uhle | Second | 12 out |
| Wednesday, July 11 |
| » Defeated Athletics (37-38), 4-2 | League Park II (23-21) | 41-36 | Won 2 |
| » Starters: Eddie Rommel vs Stan Coveleski | Second | 12 out |
| Thursday, July 12 |
| » Defeated Athletics (37-39), 11-0 | League Park II (24-21) | 42-36 | Won 3 |
| » Starters: Slim Harriss vs Guy Morton | Second | 12 out |
| Friday, July 13 |
| » Defeated Athletics (37-40), 16-7 | League Park II (25-21) | 43-36 | Won 4 |
| » Starters: Rube Walberg vs Dewey Metivier | Second | 11 out |
| Saturday, July 14 |
| » Defeated Yankees (53-25), 4-2 | League Park II (26-21) | 44-36 | Won 5 |
| » Starters: Herb Pennock vs George Uhle | Second | 11 out |
| » Lost to Yankees (54-25), 10-7 | League Park II (26-22) | 44-37 | |
| » Starters: Sam Jones vs Sherry Smith | Second | 11 out |
| Sunday, July 15 |
| » Lost to Yankees (55-25), 4-2 | League Park II (26-23) | 44-38 | Lost 2 |
| » Starters: Waite Hoyt vs Stan Coveleski | Second | 12 out |
| Monday, July 16 |
| » Defeated Yankees (55-26), 6-0 | League Park II (27-23) | 45-38 | |
| » Starters: Bob Shawkey vs Stan Coveleski | Second | 12 out |
| » Lost to Yankees (56-26), 11-7 | League Park II (27-24) | 45-39 | |
| » Starters: Joe Bush vs Sherry Smith | Second | 12 out |
| Tuesday, July 17 |
| » Defeated Yankees (56-27), 13-0 | League Park II (28-24) | 46-39 | |
| » Starters: Carl Mays vs George Uhle | Second | 11 out |
| Wednesday, July 18 |
| » Defeated Senators (34-48), 4-1 | League Park II (29-24) | 47-39 | Won 2 |
| » Starters: Walter Johnson vs Guy Morton | Second | 11 out |
| Thursday, July 19 |
| » Defeated Senators (34-49), 3-2 | League Park II (30-24) | 48-39 | Won 3 |
| » Starters: Allan Russell vs Stan Coveleski | Second | 10 out |
| Friday, July 20 |
| » Lost to Senators (35-49), 12-5 | League Park II (30-25) | 48-40 | |
| » Starters: Tom Zachary vs George Uhle | Second | 10½ out |
| Saturday, July 21 |
| » Lost to Senators (36-49), 7-5 | League Park II (30-26) | 48-41 | Lost 2 |
| » Starters: Paul Zahniser vs Guy Morton | Second | 11½ out |
| Sunday, July 22 |
| » Lost to Senators (37-49), 3-1 | League Park II (30-27) | 48-42 | Lost 3 |
| » Starters: Walter Johnson vs Stan Coveleski | Second | 12½ out |
| Monday, July 23 |
| » Defeated Browns (45-43), 9-2 | Sportsman's Park III (3-1) | 49-42 | |
| » Starters: George Uhle vs Urban Shocker | Second | 12 out |
| Tuesday, July 24 |
| » Lost to Browns (46-43), 3-1 | Sportsman's Park III (3-2) | 49-43 | |
| » Starters: Dan Boone vs Elam Vangilder | Second | 12½ out |
| » Defeated Browns (46-44), 3-2 | Sportsman's Park III (4-2) | 50-43 | |
| » Starters: Jim Joe Edwards vs Ray Kolp | Second | 12½ out |
| Wednesday, July 25 |
| » Lost to Browns (47-44), 3-2 | Sportsman's Park III (4-3) | 50-44 | |
| » Starters: Stan Coveleski vs Dave Danforth | Second | 13½ out |
| Friday, July 27 |
| Future Indian Ray Boone is born in San Diego, CA. |
| Saturday, July 28 |
| » Lost to Red Sox (34-55), 10-5 | Fenway Park (2-3) | 50-45 | Lost 2 |
| » Starters: Guy Morton vs Bill Piercy | Second | 14½ out |
| Monday, July 30 |
| » Defeated Red Sox (34-56), 5-4 | Fenway Park (3-3) | 51-45 | |
| » Starters: George Uhle vs Jack Quinn | Second | 14 out |
| » Defeated Red Sox (34-57), 2-0 | Fenway Park (4-3) | 52-45 | Won 2 |
| » Starters: Stan Coveleski vs Curt Fullerton | Second | 14 out |
| Tuesday, July 31 |
| » Defeated Red Sox (34-58), 5-4 | Fenway Park (5-3) | 53-45 | Won 3 |
| » Starters: Guy Morton vs Howard Ehmke | Second | 13½ out |
| Wednesday, August 1 |
| » Defeated Yankees (65-31), 5-3 | Yankee Stadium (4-1) | 54-45 | Won 4 |
| » Starters: Sherry Smith vs Herb Pennock | Second | 12½ out |
| Thursday, August 2 |
| » Lost to Yankees (66-31), 4-2 | Yankee Stadium (4-2) | 54-46 | |
| » Starters: Jim Joe Edwards vs Waite Hoyt | Second | 13½ out |
| Saturday, August 4 |
| » Defeated Yankees (66-32), 15-7 | Yankee Stadium (5-2) | 55-46 | |
| » Starters: George Uhle vs Bob Shawkey | Second | 12½ out |
| Sunday, August 5 |
| » Lost to Senators (45-52), 6-5 | Griffith Stadium (1-4) | 55-47 | |
| » Starters: Stan Coveleski vs Walter Johnson | Second | 13½ out |
| Monday, August 6 |
| » Defeated Senators (45-53), 5-2 | Griffith Stadium (2-4) | 56-47 | |
| » Starters: Sherry Smith vs George Mogridge | Second | 13½ out |
| Tuesday, August 7 |
| » Defeated Senators (45-54), 22-2 | Griffith Stadium (3-4) | 57-47 | Won 2 |
| » Starters: George Uhle vs Monroe Mitchell | Second | 12½ out |
| » Major-league debuts: Squire Potter (Senators) |
| Thursday, August 9 |
| » Lost to Senators (46-54), 2-1 | Griffith Stadium (3-5) | 57-48 | |
| » Starters: Stan Coveleski vs Walter Johnson | Second | 12 out |
| Saturday, August 11 |
| » Defeated Athletics (45-57), 9-5 | Shibe Park (3-1) | 58-48 | |
| » Starters: George Uhle vs Bob Hasty | Second | 12 out |
| » Defeated Athletics (45-58), 10-2 | Shibe Park (4-1) | 59-48 | Won 2 |
| » Starters: Sherry Smith vs Eddie Rommel | Second | 12 out |
| Sunday, August 12 |
| » Lost to Red Sox (42-61), 8-3 | League Park II (30-28) | 59-49 | |
| » Starters: Bill Piercy vs George Uhle | Second | 12 out |
| Monday, August 13 |
| » Lost to Athletics (46-58), 14-3 | Shibe Park (4-2) | 59-50 | Lost 2 |
| » Starters: Stan Coveleski vs Fred Heimach | Second | 12 out |
| » Defeated Athletics (46-59), 8-6 | Shibe Park (5-2) | 60-50 | |
| » Starters: Jim Joe Edwards vs Slim Harriss | Second | 12 out |
| Wednesday, August 15 |
| » Lost to Red Sox (43-61), 8-6 | League Park II (30-29) | 60-51 | |
| » Starters: Curt Fullerton vs Stan Coveleski | Second | 12 out |
| Thursday, August 16 |
| » Defeated Red Sox (43-62), 12-3 | League Park II (31-29) | 61-51 | |
| » Starters: Howard Ehmke vs George Uhle | Second | 12 out |
| Saturday, August 18 |
| » Lost to Athletics (48-62), 11-7 | League Park II (31-30) | 61-52 | |
| » Starters: Rube Walberg vs Sherry Smith | Second | 13½ out |
| Sunday, August 19 |
| » Defeated Athletics (48-63), 16-3 | League Park II (32-30) | 62-52 | |
| » Starters: Bob Hasty vs George Uhle | Second | 12½ out |
| Wednesday, August 22 |
| » Lost to Senators (55-57), 8-5 | League Park II (32-31) | 62-53 | |
| » Starters: Tom Zachary vs Jim Joe Edwards | Second | 13 out |
| Thursday, August 23 |
| » Defeated Senators (55-58), 2-1 | League Park II (33-31) | 63-53 | |
| » Starters: George Mogridge vs George Uhle | Second | 12 out |
| Friday, August 24 |
| » Lost to Senators (56-58), 20-8 | League Park II (33-32) | 63-54 | |
| » Starters: Paul Zahniser vs Phil Bedgood | Second | 13 out |
| Saturday, August 25 |
| » Defeated Yankees (75-41), 5-2 | League Park II (34-32) | 64-54 | |
| » Starters: Sam Jones vs Dan Boone | Second | 12 out |
| Sunday, August 26 |
| » Defeated Yankees (75-42), 4-3 | League Park II (35-32) | 65-54 | Won 2 |
| » Starters: Joe Bush vs George Uhle | Second | 11 out |
| Monday, August 27 |
| » Lost to Yankees (76-42), 10-3 | League Park II (35-33) | 65-55 | |
| » Starters: Bob Shawkey vs Jim Joe Edwards | Second | 12 out |
| Thursday, August 30 |
| » Defeated White Sox (55-64), 3-2 | Comiskey Park I (7-2) | 66-55 | |
| » Starters: George Uhle vs Mike Cvengros | Second | 12 out |
| Saturday, September 1 |
| » Lost to White Sox (56-64), 14-6 | Comiskey Park I (7-3) | 66-56 | |
| » Starters: Dan Boone vs Red Faber | Second | 13½ out |
| Monday, September 3 |
| » Defeated Browns (63-58), 4-2 | League Park II (36-33) | 67-56 | |
| » Starters: Dixie Davis vs George Uhle | Second | 13 out |
| » Defeated Browns (63-59), 5-2 | League Park II (37-33) | 68-56 | Won 2 |
| » Starters: Urban Shocker vs Jim Joe Edwards | Second | 13 out |
| Tuesday, September 4 |
| » Defeated Browns (63-60), 6-2 | League Park II (38-33) | 69-56 | Won 3 |
| » Starters: Dave Danforth vs Joe Shaute | Second | 13 out |
| Friday, September 7 |
| » Lost to Tigers (65-58), 11-9 | League Park II (38-34) | 69-57 | |
| » Starters: Hooks Dauss vs George Uhle | Second | 14 out |
| Saturday, September 8 |
| » Defeated Tigers (65-59), 4-3 | League Park II (39-34) | 70-57 | |
| » Starters: Syl Johnson vs Joe Shaute | Second | 13 out |
| Sunday, September 9 |
| » Defeated Tigers (65-60), 5-3 | League Park II (40-34) | 71-57 | Won 2 |
| » Starters: Herman Pillette vs Jim Joe Edwards | Second | 13½ out |
| Thursday, September 13 |
| » Lost to Red Sox (51-78), 9-8 | Fenway Park (5-4) | 71-58 | |
| » Starters: George Uhle vs Les Howe | Second | 15½ out |
| Friday, September 14 |
| » Lost to Red Sox (52-78), 4-3 | Fenway Park (5-5) | 71-59 | Lost 2 |
| » Starters: Joe Shaute vs Jack Quinn | Second | 15½ out |
| Saturday, September 15 |
| » Lost to Red Sox (53-78), 11-6 | Fenway Park (5-6) | 71-60 | Lost 3 |
| » Starters: Guy Morton vs Howard Ehmke | Second | 16½ out |
| Sunday, September 16 |
| » Lost to Yankees (91-46), 4-2 | Yankee Stadium (5-3) | 71-61 | Lost 4 |
| » Starters: George Uhle vs Waite Hoyt | Second | 18½ out |
| » Lost to Yankees (92-46), 3-2 | Yankee Stadium (5-4) | 71-62 | Lost 5 |
| » Starters: Jim Joe Edwards vs Herb Pennock | Second | 18½ out |
| Monday, September 17 |
| » Defeated Yankees (92-47), 6-2 | Yankee Stadium (6-4) | 72-62 | |
| » Starters: Sherry Smith vs Joe Bush | Second | 17½ out |
| Tuesday, September 18 |
| » Defeated Yankees (92-48), 8-3 | Yankee Stadium (7-4) | 73-62 | Won 2 |
| » Starters: Joe Shaute vs Bob Shawkey | Second | 16½ out |
| Sunday, September 23 |
| » Lost to Senators (69-71), 12-10 | Griffith Stadium (3-6) | 73-63 | |
| » Starters: George Uhle vs George Mogridge | Second | 17 out |
| » Defeated Senators (69-72), 6-0 | Griffith Stadium (4-6) | 74-63 | |
| » Starters: Jim Joe Edwards vs Walter Johnson | Second | 17 out |
| » Major-league debuts: Ted Wingfield (Senators) |
| Tuesday, September 25 |
| » Lost to Athletics (62-78), 6-5 | Shibe Park (5-3) | 74-64 | |
| » Starters: Sherry Smith vs Fred Heimach | Second | 18 out |
| » Lost to Athletics (63-78), 5-1 | Shibe Park (5-4) | 74-65 | Lost 2 |
| » Starters: Joe Shaute vs Roy Meeker | Second | 18 out |
| Wednesday, September 26 |
| » Defeated Athletics (63-79), 5-3 | Shibe Park (6-4) | 75-65 | |
| » Starters: Jim Joe Edwards vs Rube Walberg | Second | 16½ out |
| » Defeated Athletics (63-80), 6-2 | Shibe Park (7-4) | 76-65 | Won 2 |
| » Starters: George Uhle vs Dennis Burns | Second | 16½ out |
| Thursday, September 27 |
| » Lost to Tigers (75-69), 5-4 | Tiger Stadium (2-6) | 76-66 | |
| » Starters: Joe Shaute vs Hooks Dauss | Second | 17½ out |
| Friday, September 28 |
| » Lost to Tigers (76-69), 17-3 | Tiger Stadium (2-7) | 76-67 | Lost 2 |
| » Starters: Sherry Smith vs Herman Pillette | Second | 18½ out |
| » Major-league debuts: Dutch Levsen (Indians) |
| Saturday, September 29 |
| » Lost to Tigers (77-69), 3-0 | Tiger Stadium (2-8) | 76-68 | Lost 3 |
| » Starters: George Uhle vs Hooks Dauss | Second | 18 out |
| Sunday, September 30 |
| » Defeated Tigers (77-70), 4-3 | Tiger Stadium (3-8) | 77-68 | |
| » Starters: Jim Joe Edwards vs Ray Francis | Second | 17½ out |
| Monday, October 1 |
| » Defeated Browns (73-73), 13-5 | Sportsman's Park III (5-3) | 78-68 | Won 2 |
| » Starters: Joe Shaute vs Dave Danforth | Second | 17 out |
| Tuesday, October 2 |
| » Lost to Browns (74-73), 10-5 | Sportsman's Park III (5-4) | 78-69 | |
| » Starters: Sherry Smith vs Elam Vangilder | Second | 17½ out |
| Wednesday, October 3 |
| » Defeated Browns (74-74), 9-2 | Sportsman's Park III (6-4) | 79-69 | |
| » Starters: George Uhle vs Ray Kolp | Second | 17 out |
| Thursday, October 4 |
| » Defeated Browns (74-75), 9-1 | Sportsman's Park III (7-4) | 80-69 | Won 2 |
| » Starters: Jim Joe Edwards vs Rasty Wright | Second | 16 out |
| Friday, October 5 |
| » Defeated White Sox (67-84), 6-1 | League Park II (41-34) | 81-69 | Won 3 |
| » Starters: Sloppy Thurston vs Joe Shaute | Second | 16 out |
| Saturday, October 6 |
| » Lost to White Sox (68-84), 6-3 | League Park II (41-35) | 81-70 | |
| » Starters: Red Faber vs George Uhle | Third | 17½ out |
| » Lost to White Sox (69-84), 7-6 | League Park II (41-36) | 81-71 | Lost 2 |
| » Starters: Charlie Robertson vs Jim Joe Edwards | Third | 17½ out |
| Sunday, October 7 |
| » Defeated White Sox (69-85), 9-6 | League Park II (42-36) | 82-71 | |
| » Starters: Ted Blankenship vs Joe Shaute | Third | 16½ out |
| Friday, November 9 |
| Future Indian Ted Sepkowski is born in Baltimore, MD. |
| Saturday, November 17 |
| Future Indian Mike Garcia is born in San Gabriel, CA. |
| Thursday, December 13 |
| Future Indian Larry Doby is born in Camden, SC. |
Game information provided by Retrosheet (www.retrosheet.org) |
