| Wednesday, April 14 |
| » Major-league debuts: Bob Meusel (Yankees) |
| Thursday, April 15 |
| » Defeated Senators (0-1), 7-6 | Fenway Park (1-0) | 1-0 | |
| » Starters: Walter Johnson vs Allen Russell | First | -- |
| » Major-league debuts: Jim O'Neill (Senators) |
| Saturday, April 17 |
| » Defeated Senators (0-2), 2-1 | Fenway Park (2-0) | 2-0 | Won 2 |
| » Starters: Eric Erickson vs Sad Sam Jones | First | -- |
| Monday, April 19 |
| » Defeated Yankees (1-2), 6-0 | Fenway Park (3-0) | 3-0 | Won 3 |
| » Starters: George Mogridge vs Waite Hoyt | First | -- |
| » Defeated Yankees (1-3), 8-3 | Fenway Park (4-0) | 4-0 | Won 4 |
| » Starters: Carl Mays vs Bullet Joe Bush | First | -- |
| » Major-league debuts: Rip Collins (Yankees) |
| Tuesday, April 20 |
| » Defeated Yankees (1-4), 3-2 | Fenway Park (5-0) | 5-0 | Won 5 |
| » Starters: Bob Shawkey vs Herb Pennock | First | -- |
| » Major-league debuts: Benn Karr (Red Sox) |
| Thursday, April 22 |
| » Lost to Senators (3-2), 8-5 | Griffith Stadium (0-1) | 5-1 | |
| » Starters: Allen Russell vs Jim Shaw | Second | 1 out |
| Friday, April 23 |
| » Defeated Senators (3-3), 4-2 | Griffith Stadium (1-1) | 6-1 | |
| » Starters: Sad Sam Jones vs Harry Courtney | Second | 1½ out |
| Saturday, April 24 |
| » Defeated Senators (3-4), 7-3 | Griffith Stadium (2-1) | 7-1 | Won 2 |
| » Starters: Waite Hoyt vs Jim Shaw | Second | 1½ out |
| Sunday, April 25 |
| » Lost to Senators (4-4), 2-0 | Griffith Stadium (2-2) | 7-2 | |
| » Starters: Bullet Joe Bush vs Walter Johnson | Second | 1½ out |
| Monday, April 26 |
| » Defeated Athletics (2-6), 9-0 | Shibe Park (1-0) | 8-2 | |
| » Starters: Herb Pennock vs Scott Perry | Second | 2 out |
| Wednesday, April 28 |
| » Tied Athletics, 7-7 | Shibe Park (1-0) | 8-2 | |
| » Starters: Sad Sam Jones vs Walt Kinney | First | -- |
| Thursday, April 29 |
| » Defeated Athletics (2-7), 7-1 | Shibe Park (2-0) | 9-2 | Won 2 |
| » Starters: Bullet Joe Bush vs Rollie Naylor | First | -- |
| Friday, April 30 |
| » Defeated Yankees (4-7), 4-2 | Polo Grounds V (1-0) | 10-2 | Won 3 |
| » Starters: Waite Hoyt vs Carl Mays | First | -- |
| Saturday, May 1 |
| » Lost to Yankees (5-7), 6-0 | Polo Grounds V (1-1) | 10-3 | |
| » Starters: Herb Pennock vs Bob Shawkey | Second | 1½ out |
| Sunday, May 2 |
| » Lost to Yankees (6-7), 7-1 | Polo Grounds V (1-2) | 10-4 | Lost 2 |
| » Starters: Sad Sam Jones vs Hank Thormahlen | Third | 1½ out |
| Monday, May 3 |
| » Defeated Yankees (6-8), 3-1 | Polo Grounds V (2-2) | 11-4 | |
| » Starters: Allen Russell vs George Mogridge | Second | 1½ out |
| Tuesday, May 4 |
| » Lost to Yankees (7-8), 6-1 | Polo Grounds V (2-3) | 11-5 | |
| » Starters: Waite Hoyt vs Jack Quinn | Second | 1½ out |
| Wednesday, May 5 |
| » Defeated Athletics (5-10), 4-3 | Fenway Park (6-0) | 12-5 | |
| » Starters: Walt Kinney vs Bullet Joe Bush | Second | 1½ out |
| Thursday, May 6 |
| » Defeated Athletics (5-11), 3-1 | Fenway Park (7-0) | 13-5 | Won 2 |
| » Starters: Dave Keefe vs Sad Sam Jones | First | -- |
| Friday, May 7 |
| » Lost to Athletics (6-11), 5-4 | Fenway Park (7-1) | 13-6 | |
| » Starters: Rollie Naylor vs Allen Russell | Second | 1½ out |
| Monday, May 10 |
| » Defeated Athletics (6-12), 7-1 | Fenway Park (8-1) | 14-6 | |
| » Starters: Scott Perry vs Harry Harper | Second | ½ out |
| Wednesday, May 12 |
| » Lost to Indians (16-6), 9-7 | Fenway Park (8-2) | 14-7 | |
| » Starters: Ray Caldwell vs Bullet Joe Bush | Second | 1½ out |
| Saturday, May 15 |
| » Lost to White Sox (12-9), 2-1 | Fenway Park (8-3) | 14-8 | Lost 2 |
| » Starters: Red Faber vs Herb Pennock | Second | 1½ out |
| Monday, May 17 |
| » Defeated White Sox (12-10), 2-1 | Fenway Park (9-3) | 15-8 | |
| » Starters: Roy Wilkinson vs Sad Sam Jones | Second | 1½ out |
| Tuesday, May 18 |
| » Lost to White Sox (13-10), 4-3 | Fenway Park (9-4) | 15-9 | |
| » Starters: Lefty Williams vs Bullet Joe Bush | Second | 1½ out |
| Wednesday, May 19 |
| » Defeated White Sox (13-11), 3-2 | Fenway Park (10-4) | 16-9 | |
| » Starters: Eddie Cicotte vs Harry Harper | Second | 1½ out |
| Thursday, May 20 |
| » Defeated Tigers (7-20), 6-0 | Fenway Park (11-4) | 17-9 | Won 2 |
| » Starters: Dutch Leonard vs Herb Pennock | Second | 1½ out |
| » Major-league debuts: Larry Woodall (Tigers) |
| Friday, May 21 |
| » Defeated Tigers (7-21), 8-3 | Fenway Park (12-4) | 18-9 | Won 3 |
| » Starters: Hooks Dauss vs Allen Russell | Second | 1½ out |
| Monday, May 24 |
| » Defeated Browns (13-16), 5-1 | Fenway Park (13-4) | 19-9 | Won 4 |
| » Starters: Elam Vangilder vs Bullet Joe Bush | Second | 1 out |
| Tuesday, May 25 |
| » Defeated Browns (13-17), 3-2 | Fenway Park (14-4) | 20-9 | Won 5 |
| » Starters: Allen Sothoron vs Sad Sam Jones | Second | ½ out |
| Wednesday, May 26 |
| » Defeated Browns (13-18), 9-5 | Fenway Park (15-4) | 21-9 | Won 6 |
| » Starters: Urban Shocker vs Herb Pennock | First | -- |
| Thursday, May 27 |
| » Lost to Yankees (18-15), 6-1 | Fenway Park (15-5) | 21-10 | |
| » Starters: Bob Shawkey vs Harry Harper | First | -- |
| Friday, May 28 |
| » Lost to Yankees (19-15), 4-3 | Fenway Park (15-6) | 21-11 | Lost 2 |
| » Starters: Ernie Shore vs Allen Russell | Second | 1 out |
| Saturday, May 29 |
| » Lost to Yankees (20-15), 4-3 | Fenway Park (15-7) | 21-12 | Lost 3 |
| » Starters: Jack Quinn vs Bullet Joe Bush | Second | 2 out |
| » Lost to Yankees (21-15), 8-3 | Fenway Park (15-8) | 21-13 | Lost 4 |
| » Starters: Carl Mays vs Sad Sam Jones | Second | 2 out |
| Monday, May 31 |
| » Defeated Athletics (12-25), 3-1 | Fenway Park (16-8) | 22-13 | |
| » Starters: Rollie Naylor vs Herb Pennock | Second | 3½ out |
| » Lost to Athletics (13-25), 9-4 | Fenway Park (16-9) | 22-14 | |
| » Starters: Scott Perry vs Harry Harper | Second | 3½ out |
| Tuesday, June 1 |
| » Lost to Athletics (14-25), 8-6 | Fenway Park (16-10) | 22-15 | Lost 2 |
| » Starters: Bob Hasty vs Harry Harper | Third | 4 out |
| » Lost to Athletics (15-25), 7-2 | Fenway Park (16-11) | 22-16 | Lost 3 |
| » Starters: Slim Harriss vs Bullet Joe Bush | Third | 4 out |
| Thursday, June 3 |
| » Lost to Senators (21-20), 2-1 | Griffith Stadium (2-3) | 22-17 | Lost 4 |
| » Starters: Allen Russell vs Walter Johnson | Third | 4½ out |
| Sunday, June 6 |
| » Lost to Senators (22-20), 5-4 | Griffith Stadium (2-4) | 22-18 | Lost 5 |
| » Starters: Herb Pennock vs Bill Snyder | Third | 4 out |
| Tuesday, June 8 |
| » Defeated White Sox (25-20), 4-1 | Comiskey Park I (1-0) | 23-18 | |
| » Starters: Sad Sam Jones vs Roy Wilkinson | Third | 4 out |
| Wednesday, June 9 |
| » Defeated White Sox (25-21), 3-2 | Comiskey Park I (2-0) | 24-18 | Won 2 |
| » Starters: Bullet Joe Bush vs Lefty Williams | Third | 4 out |
| Thursday, June 10 |
| » Defeated White Sox (25-22), 8-1 | Comiskey Park I (3-0) | 25-18 | Won 3 |
| » Starters: Harry Harper vs Eddie Cicotte | Third | 4 out |
| Friday, June 11 |
| » Lost to White Sox (26-22), 5-4 | Comiskey Park I (3-1) | 25-19 | |
| » Starters: Herb Pennock vs Red Faber | Third | 5 out |
| Saturday, June 12 |
| » Lost to Browns (20-27), 15-4 | Sportsman's Park III (0-1) | 25-20 | Lost 2 |
| » Starters: Sad Sam Jones vs Allen Sothoron | Third | 6 out |
| Sunday, June 13 |
| » Lost to Browns (21-27), 11-5 | Sportsman's Park III (0-2) | 25-21 | Lost 3 |
| » Starters: Sad Sam Jones vs Urban Shocker | Fourth | 6 out |
| Monday, June 14 |
| » Lost to Browns (22-27), 10-5 | Sportsman's Park III (0-3) | 25-22 | Lost 4 |
| » Starters: Allen Russell vs Dixie Davis | Fourth | 7 out |
| Tuesday, June 15 |
| » Lost to Browns (23-27), 12-8 | Sportsman's Park III (0-4) | 25-23 | Lost 5 |
| » Starters: Herb Pennock vs Elam Vangilder | Fourth | 8 out |
| Thursday, June 17 |
| » Defeated Tigers (18-34), 2-1 | Tiger Stadium (1-0) | 26-23 | |
| » Starters: Bullet Joe Bush vs Hooks Dauss | Fourth | 7½ out |
| Friday, June 18 |
| » Lost to Tigers (19-34), 1-0 | Tiger Stadium (1-1) | 26-24 | |
| » Starters: Sad Sam Jones vs Doc Ayers | Fourth | 8½ out |
| Saturday, June 19 |
| » Defeated Tigers (19-35), 4-3 | Tiger Stadium (2-1) | 27-24 | |
| » Starters: Allen Russell vs Howard Ehmke | Fourth | 7½ out |
| Sunday, June 20 |
| » Defeated Indians (36-19), 10-9 | League Park II (1-0) | 28-24 | Won 2 |
| » Starters: Herb Pennock vs Jim Bagby | Fourth | 6½ out |
| Monday, June 21 |
| » Lost to Indians (37-19), 3-2 | League Park II (1-1) | 28-25 | |
| » Starters: Harry Harper vs George Uhle | Fourth | 7½ out |
| Tuesday, June 22 |
| » Lost to Indians (38-19), 13-5 | League Park II (1-2) | 28-26 | Lost 2 |
| » Starters: Bullet Joe Bush vs Ray Caldwell | Fourth | 8½ out |
| Future Red Sox Walt Masterson is born in Philadelphia, PA. |
| Wednesday, June 23 |
| » Lost to Indians (39-19), 7-6 | League Park II (1-3) | 28-27 | Lost 3 |
| » Starters: Sad Sam Jones vs Guy Morton | Fifth | 9½ out |
| Friday, June 25 |
| » Defeated Yankees (39-23), 6-3 | Polo Grounds V (3-3) | 29-27 | |
| » Starters: Herb Pennock vs Jack Quinn | Fifth | 8½ out |
| Saturday, June 26 |
| » Lost to Yankees (40-23), 14-0 | Polo Grounds V (3-4) | 29-28 | |
| » Starters: Bullet Joe Bush vs Rip Collins | Fifth | 8½ out |
| Sunday, June 27 |
| » Lost to Yankees (41-23), 7-5 | Polo Grounds V (3-5) | 29-29 | Lost 2 |
| » Starters: Allen Russell vs Carl Mays | Fifth | 9½ out |
| Tuesday, June 29 |
| » Lost to Yankees (42-23), 6-5 | Polo Grounds V (3-6) | 29-30 | Lost 3 |
| » Starters: Sad Sam Jones vs Ernie Shore | Fifth | 11½ out |
| Wednesday, June 30 |
| » Defeated Senators (31-28), 4-3 | Fenway Park (17-11) | 30-30 | |
| » Starters: Jim Shaw vs Bullet Joe Bush | Fifth | 11 out |
| » Lost to Senators (32-28), 5-2 | Fenway Park (17-12) | 30-31 | |
| » Starters: Tom Zachary vs Herb Pennock | Fifth | 11 out |
| Thursday, July 1 |
| » Lost to Senators (33-28), 1-0 | Fenway Park (17-13) | 30-32 | Lost 2 |
| » Starters: Walter Johnson vs Harry Harper | Fifth | 12 out |
| Friday, July 2 |
| » Defeated Senators (33-29), 10-9 | Fenway Park (18-13) | 31-32 | |
| » Starters: Eric Erickson vs Sad Sam Jones | Fifth | 12 out |
| Monday, July 5 |
| » Defeated Athletics (17-54), 6-1 | Shibe Park (3-0) | 32-32 | Won 2 |
| » Starters: Herb Pennock vs Bob Hasty | Fifth | 10½ out |
| » Defeated Athletics (17-55), 10-3 | Shibe Park (4-0) | 33-32 | Won 3 |
| » Starters: Bullet Joe Bush vs Slim Harriss | Fifth | 10½ out |
| Tuesday, July 6 |
| » Defeated Athletics (17-56), 11-0 | Shibe Park (5-0) | 34-32 | Won 4 |
| » Starters: Sad Sam Jones vs Roy Moore | Fifth | 11 out |
| » Lost to Athletics (18-56), 5-1 | Shibe Park (5-1) | 34-33 | |
| » Starters: Harry Harper vs Rollie Naylor | Fifth | 11 out |
| Wednesday, July 7 |
| » Lost to Athletics (19-56), 6-0 | Shibe Park (5-2) | 34-34 | Lost 2 |
| » Starters: Benn Karr vs Dave Keefe | Fifth | 12 out |
| » Lost to Athletics (20-56), 1-0 | Shibe Park (5-3) | 34-35 | Lost 3 |
| » Starters: Gary Fortune vs Scott Perry | Fifth | 12 out |
| Thursday, July 8 |
| » Lost to Browns (35-38), 4-0 | Fenway Park (18-14) | 34-36 | Lost 4 |
| » Starters: Urban Shocker vs Herb Pennock | Fifth | 12½ out |
| Friday, July 9 |
| » Defeated Browns (35-39), 2-1 | Fenway Park (19-14) | 35-36 | |
| » Starters: Dixie Davis vs Bullet Joe Bush | Fifth | 12½ out |
| Saturday, July 10 |
| » Lost to Browns (36-39), 9-2 | Fenway Park (19-15) | 35-37 | |
| » Starters: Allen Sothoron vs Sad Sam Jones | Fifth | 13 out |
| Monday, July 12 |
| » Lost to Browns (37-39), 3-2 | Fenway Park (19-16) | 35-38 | Lost 2 |
| » Starters: Elam Vangilder vs Harry Harper | Sixth | 14 out |
| Tuesday, July 13 |
| » Lost to Tigers (24-50), 10-4 | Fenway Park (19-17) | 35-39 | Lost 3 |
| » Starters: Dutch Leonard vs Herb Pennock | Sixth | 15 out |
| Wednesday, July 14 |
| » Defeated Tigers (24-51), 6-5 | Fenway Park (20-17) | 36-39 | |
| » Starters: Doc Ayers vs Bullet Joe Bush | Sixth | 14½ out |
| » Defeated Tigers (24-52), 4-0 | Fenway Park (21-17) | 37-39 | Won 2 |
| » Starters: Red Oldham vs Herb Pennock | Sixth | 14½ out |
| Friday, July 16 |
| » Lost to Tigers (25-52), 6-5 | Fenway Park (21-18) | 37-40 | |
| » Starters: Hooks Dauss vs Gary Fortune | Sixth | 15 out |
| Saturday, July 17 |
| » Lost to Indians (55-27), 5-2 | Fenway Park (21-19) | 37-41 | Lost 2 |
| » Starters: Ray Caldwell vs Sad Sam Jones | Sixth | 17 out |
| » Lost to Indians (56-27), 5-2 | Fenway Park (21-20) | 37-42 | Lost 3 |
| » Starters: Guy Morton vs Harry Harper | Sixth | 17 out |
| Monday, July 19 |
| » Lost to Indians (57-27), 10-6 | Fenway Park (21-21) | 37-43 | Lost 4 |
| » Starters: Stan Coveleski vs Bullet Joe Bush | Sixth | 17 out |
| » Defeated Indians (57-28), 5-4 | Fenway Park (22-21) | 38-43 | |
| » Starters: Jim Bagby vs Herb Pennock | Sixth | 17 out |
| Tuesday, July 20 |
| » Lost to Indians (58-28), 9-8 | Fenway Park (22-22) | 38-44 | |
| » Starters: Guy Morton vs Gary Fortune | Sixth | 18 out |
| Wednesday, July 21 |
| » Defeated White Sox (52-35), 2-1 | Fenway Park (23-22) | 39-44 | |
| » Starters: Lefty Williams vs Sad Sam Jones | Sixth | 17 out |
| Thursday, July 22 |
| » Lost to White Sox (53-35), 2-1 | Fenway Park (23-23) | 39-45 | |
| » Starters: Dickie Kerr vs Harry Harper | Sixth | 17 out |
| Friday, July 23 |
| » Lost to White Sox (54-35), 8-7 | Fenway Park (23-24) | 39-46 | Lost 2 |
| » Starters: Red Faber vs Herb Pennock | Sixth | 18 out |
| Saturday, July 24 |
| » Lost to White Sox (55-35), 7-4 | Fenway Park (23-25) | 39-47 | Lost 3 |
| » Starters: Eddie Cicotte vs Bullet Joe Bush | Sixth | 18 out |
| Sunday, July 25 |
| » Lost to Yankees (62-33), 8-2 | Polo Grounds V (3-7) | 39-48 | Lost 4 |
| » Starters: Waite Hoyt vs Carl Mays | Sixth | 19 out |
| Monday, July 26 |
| » Defeated Yankees (62-34), 9-0 | Polo Grounds V (4-7) | 40-48 | |
| » Starters: Sad Sam Jones vs Rip Collins | Sixth | 18½ out |
| Wednesday, July 28 |
| » Lost to Indians (62-32), 8-0 | League Park II (1-4) | 40-49 | |
| » Starters: Harry Harper vs Jim Bagby | Sixth | 19½ out |
| Thursday, July 29 |
| » Lost to Indians (63-32), 9-3 | League Park II (1-5) | 40-50 | Lost 2 |
| » Starters: Herb Pennock vs Stan Coveleski | Sixth | 20½ out |
| Friday, July 30 |
| » Lost to Indians (64-32), 13-4 | League Park II (1-6) | 40-51 | Lost 3 |
| » Starters: Bullet Joe Bush vs Ray Caldwell | Sixth | 21½ out |
| Saturday, July 31 |
| » Lost to Indians (65-32), 2-1 | League Park II (1-7) | 40-52 | Lost 4 |
| » Starters: Sad Sam Jones vs Guy Morton | Sixth | 22½ out |
| Sunday, August 1 |
| » Defeated Tigers (35-59), 4-2 | Tiger Stadium (3-1) | 41-52 | |
| » Starters: Waite Hoyt vs Howard Ehmke | Sixth | 21½ out |
| Monday, August 2 |
| » Lost to Tigers (36-59), 5-2 | Tiger Stadium (3-2) | 41-53 | |
| » Starters: Bullet Joe Bush vs Red Oldham | Sixth | 23 out |
| » Lost to Tigers (37-59), 2-1 | Tiger Stadium (3-3) | 41-54 | Lost 2 |
| » Starters: Harry Harper vs Hooks Dauss | Sixth | 23 out |
| Tuesday, August 3 |
| » Defeated Tigers (37-60), 3-1 | Tiger Stadium (4-3) | 42-54 | |
| » Starters: Herb Pennock vs Doc Ayers | Sixth | 23 out |
| Wednesday, August 4 |
| » Defeated Tigers (37-61), 5-1 | Tiger Stadium (5-3) | 43-54 | Won 2 |
| » Starters: Bullet Joe Bush vs Dutch Leonard | Sixth | 22 out |
| Thursday, August 5 |
| » Defeated White Sox (63-40), 4-2 | Comiskey Park I (4-1) | 44-54 | Won 3 |
| » Starters: Sad Sam Jones vs Eddie Cicotte | Sixth | 21½ out |
| Friday, August 6 |
| » Lost to White Sox (64-40), 4-3 | Comiskey Park I (4-2) | 44-55 | |
| » Starters: Elmer Myers vs Lefty Williams | Sixth | 21½ out |
| Saturday, August 7 |
| » Defeated White Sox (64-41), 4-2 | Comiskey Park I (5-2) | 45-55 | |
| » Starters: Harry Harper vs Red Faber | Sixth | 21½ out |
| Sunday, August 8 |
| » Lost to White Sox (65-41), 2-0 | Comiskey Park I (5-3) | 45-56 | |
| » Starters: Herb Pennock vs Dickie Kerr | Sixth | 22½ out |
| Monday, August 9 |
| » Defeated Browns (51-52), 5-4 | Sportsman's Park III (1-4) | 46-56 | |
| » Starters: Sad Sam Jones vs Dixie Davis | Sixth | 21½ out |
| Tuesday, August 10 |
| » Lost to Browns (52-52), 6-4 | Sportsman's Park III (1-5) | 46-57 | |
| » Starters: Bullet Joe Bush vs Adrian Lynch | Sixth | 22 out |
| Wednesday, August 11 |
| » Defeated Browns (52-53), 5-3 | Sportsman's Park III (2-5) | 47-57 | |
| » Starters: Harry Harper vs Allen Sothoron | Fifth | 21 out |
| Friday, August 13 |
| » Lost to Athletics (35-74), 3-1 | Shibe Park (5-4) | 47-58 | |
| » Starters: Sad Sam Jones vs Scott Perry | Fifth | 20 out |
| » Defeated Athletics (35-75), 7-0 | Shibe Park (6-4) | 48-58 | |
| » Starters: Elmer Myers vs Rollie Naylor | Fifth | 20 out |
| Saturday, August 14 |
| » Defeated Athletics (35-76), 6-3 | Shibe Park (7-4) | 49-58 | Won 2 |
| » Starters: Bullet Joe Bush vs Dave Keefe | Fifth | 19 out |
| Monday, August 16 |
| » Defeated Tigers (41-68), 6-4 | Fenway Park (24-25) | 50-58 | Won 3 |
| » Starters: Hooks Dauss vs Herb Pennock | Fifth | 19½ out |
| Tuesday, August 17 |
| » Defeated Tigers (41-69), 4-3 | Fenway Park (25-25) | 51-58 | Won 4 |
| » Starters: Red Oldham vs Sad Sam Jones | Fifth | 19½ out |
| » Lost to Tigers (42-69), 3-1 | Fenway Park (25-26) | 51-59 | |
| » Starters: Howard Ehmke vs Harry Harper | Fifth | 19½ out |
| Wednesday, August 18 |
| » Defeated Tigers (42-70), 6-5 | Fenway Park (26-26) | 52-59 | |
| » Starters: Doc Ayers vs Elmer Myers | Fifth | 18½ out |
| Thursday, August 19 |
| » Lost to Tigers (43-70), 4-0 | Fenway Park (26-27) | 52-60 | |
| » Starters: Dutch Leonard vs Bullet Joe Bush | Fifth | 19½ out |
| Saturday, August 21 |
| » Defeated Indians (72-42), 12-0 | Fenway Park (27-27) | 53-60 | |
| » Starters: Guy Morton vs Waite Hoyt | Fifth | 19 out |
| » Defeated Indians (72-43), 4-0 | Fenway Park (28-27) | 54-60 | Won 2 |
| » Starters: Stan Coveleski vs Herb Pennock | Fifth | 19 out |
| Monday, August 23 |
| » Lost to Indians (73-43), 2-1 | Fenway Park (28-28) | 54-61 | |
| » Starters: Ray Caldwell vs Sad Sam Jones | Fifth | 19½ out |
| » Defeated Indians (73-44), 4-3 | Fenway Park (29-28) | 55-61 | |
| » Starters: Jim Bagby vs Harry Harper | Fifth | 19½ out |
| Tuesday, August 24 |
| » Defeated Indians (73-45), 7-2 | Fenway Park (30-28) | 56-61 | Won 2 |
| » Starters: Bob Clark vs Bullet Joe Bush | Fifth | 18½ out |
| Wednesday, August 25 |
| » Defeated Browns (58-57), 11-1 | Fenway Park (31-28) | 57-61 | Won 3 |
| » Starters: Allen Sothoron vs Elmer Myers | Fifth | 18 out |
| Thursday, August 26 |
| » Lost to Browns (59-57), 8-0 | Fenway Park (31-29) | 57-62 | |
| » Starters: Carl Weilman vs Waite Hoyt | Fifth | 19 out |
| Friday, August 27 |
| » Lost to Browns (60-57), 6-5 | Fenway Park (31-30) | 57-63 | Lost 2 |
| » Starters: Dixie Davis vs Herb Pennock | Fifth | 19 out |
| Saturday, August 28 |
| » Lost to Browns (61-57), 7-0 | Fenway Park (31-31) | 57-64 | Lost 3 |
| » Starters: Joe DeBerry vs Harry Harper | Fifth | 19 out |
| Monday, August 30 |
| » Defeated White Sox (77-47), 4-0 | Fenway Park (32-31) | 58-64 | |
| » Starters: Lefty Williams vs Sad Sam Jones | Fifth | 18 out |
| Tuesday, August 31 |
| » Defeated White Sox (77-48), 7-3 | Fenway Park (33-31) | 59-64 | Won 2 |
| » Starters: Eddie Cicotte vs Bullet Joe Bush | Fifth | 17 out |
| Wednesday, September 1 |
| » Defeated White Sox (77-49), 6-2 | Fenway Park (34-31) | 60-64 | Won 3 |
| » Starters: Dickie Kerr vs Herb Pennock | Fifth | 16½ out |
| Thursday, September 2 |
| » Defeated Yankees (78-51), 6-2 | Fenway Park (35-31) | 61-64 | Won 4 |
| » Starters: Bob Shawkey vs Elmer Myers | Fifth | 16 out |
| Friday, September 3 |
| » Lost to Yankees (79-51), 5-3 | Fenway Park (35-32) | 61-65 | |
| » Starters: Jack Quinn vs Waite Hoyt | Fifth | 16 out |
| Saturday, September 4 |
| » Lost to Yankees (80-51), 5-3 | Fenway Park (35-33) | 61-66 | Lost 2 |
| » Starters: Rip Collins vs Sad Sam Jones | Fifth | 16½ out |
| » Defeated Yankees (80-52), 6-5 | Fenway Park (36-33) | 62-66 | |
| » Starters: Carl Mays vs Bullet Joe Bush | Fifth | 16½ out |
| Sunday, September 5 |
| » Lost to Senators (54-68), 5-3 | Griffith Stadium (2-5) | 62-67 | |
| » Starters: Herb Pennock vs Harry Courtney | Fifth | 17½ out |
| Monday, September 6 |
| » Lost to Senators (55-68), 6-0 | Griffith Stadium (2-6) | 62-68 | Lost 2 |
| » Starters: Sad Sam Jones vs Tom Zachary | Fifth | 19½ out |
| » Lost to Senators (56-68), 6-4 | Griffith Stadium (2-7) | 62-69 | Lost 3 |
| » Starters: Waite Hoyt vs Harry Biemiller | Fifth | 19½ out |
| Tuesday, September 7 |
| » Lost to Senators (57-68), 5-1 | Griffith Stadium (2-8) | 62-70 | Lost 4 |
| » Starters: Harry Harper vs Jim Shaw | Fifth | 19½ out |
| » Defeated Senators (57-69), 5-3 | Griffith Stadium (3-8) | 63-70 | |
| » Starters: Elmer Myers vs Harry Courtney | Fifth | 19½ out |
| Thursday, September 9 |
| » Lost to White Sox (83-52), 6-5 | Comiskey Park I (5-4) | 63-71 | |
| » Starters: Bullet Joe Bush vs Eddie Cicotte | Fifth | 20½ out |
| Friday, September 10 |
| » Lost to White Sox (84-52), 5-3 | Comiskey Park I (5-5) | 63-72 | Lost 2 |
| » Starters: Herb Pennock vs Red Faber | Fifth | 20½ out |
| Saturday, September 11 |
| » Defeated White Sox (84-53), 9-7 | Comiskey Park I (6-5) | 64-72 | |
| » Starters: Sad Sam Jones vs Dickie Kerr | Fifth | 19½ out |
| Sunday, September 12 |
| » Defeated Browns (66-67), 9-7 | Sportsman's Park III (3-5) | 65-72 | Won 2 |
| » Starters: Waite Hoyt vs Joe DeBerry | Fifth | 20 out |
| Monday, September 13 |
| » Defeated Browns (66-68), 5-4 | Sportsman's Park III (4-5) | 66-72 | Won 3 |
| » Starters: Elmer Myers vs Bill Bayne | Fifth | 19½ out |
| Tuesday, September 14 |
| » Lost to Browns (67-68), 7-4 | Sportsman's Park III (4-6) | 66-73 | |
| » Starters: Harry Harper vs Dixie Davis | Fifth | 21 out |
| Wednesday, September 15 |
| » Lost to Browns (68-68), 18-5 | Sportsman's Park III (4-7) | 66-74 | Lost 2 |
| » Starters: Benn Karr vs Carl Weilman | Fifth | 21½ out |
| Thursday, September 16 |
| » Lost to Tigers (54-84), 7-6 | Tiger Stadium (5-4) | 66-75 | Lost 3 |
| » Starters: Bullet Joe Bush vs Roy Crumpler | Fifth | 21½ out |
| Friday, September 17 |
| » Lost to Tigers (55-84), 14-13 | Tiger Stadium (5-5) | 66-76 | Lost 4 |
| » Starters: Sad Sam Jones vs John Bogart | Fifth | 22½ out |
| » Major-league debuts: Clarence Huber (Tigers) |
| Saturday, September 18 |
| » Defeated Tigers (55-85), 7-4 | Tiger Stadium (6-5) | 67-76 | |
| » Starters: Elmer Myers vs Mutt Wilson | Fifth | 22½ out |
| Sunday, September 19 |
| » Lost to Indians (89-52), 2-0 | League Park II (1-8) | 67-77 | |
| » Starters: Herb Pennock vs Jim Bagby | Fifth | 23½ out |
| Monday, September 20 |
| » Lost to Indians (90-52), 8-3 | League Park II (1-9) | 67-78 | Lost 2 |
| » Starters: Bullet Joe Bush vs Duster Mails | Fifth | 24½ out |
| Tuesday, September 21 |
| » Lost to Indians (91-52), 12-1 | League Park II (1-10) | 67-79 | Lost 3 |
| » Starters: Sad Sam Jones vs Stan Coveleski | Fifth | 25½ out |
| Wednesday, September 22 |
| » Major-league debuts: Clyde Barnhart (Pirates) |
| Thursday, September 23 |
| » Defeated Athletics (46-99), 9-2 | Fenway Park (37-33) | 68-79 | |
| » Starters: Scott Perry vs Elmer Myers | Fifth | 24½ out |
| Friday, September 24 |
| » Lost to Athletics (47-99), 10-9 | Fenway Park (37-34) | 68-80 | |
| » Starters: Rollie Naylor vs Herb Pennock | Fifth | 25½ out |
| » Major-league debuts: Ray Grimes (Red Sox) |
| Saturday, September 25 |
| » Defeated Athletics (47-100), 4-2 | Fenway Park (38-34) | 69-80 | |
| » Starters: Dave Keefe vs Bullet Joe Bush | Fifth | 24½ out |
| Sunday, September 26 |
| » Major-league debuts: Doc Prothro (Senators) |
| Monday, September 27 |
| » Defeated Senators (64-81), 2-1 | Fenway Park (39-34) | 70-80 | Won 2 |
| » Starters: Al Schacht vs Sad Sam Jones | Fifth | 24½ out |
| » Defeated Senators (64-82), 2-0 | Fenway Park (40-34) | 71-80 | Won 3 |
| » Starters: Eric Erickson vs Harry Harper | Fifth | 24½ out |
| Tuesday, September 28 |
| » Defeated Senators (64-83), 5-3 | Fenway Park (41-34) | 72-80 | Won 4 |
| » Starters: Jim Shaw vs Herb Pennock | Fifth | 25 out |
| » Lost to Senators (65-83), 7-6 | Fenway Park (41-35) | 72-81 | |
| » Starters: Harry Courtney vs Elmer Myers | Fifth | 25 out |
| Friday, October 8 |
| Future Red Sox Catfish Metkovich is born in Angels Camp, CA. |
| Saturday, October 23 |
| Future Red Sox Vern Stephens is born in McAlister, NM. |
| Tuesday, October 26 |
| Future Red Sox Bud Byerly is born in Webster Groves, MO. |
| Tuesday, November 23 |
| Future Red Sox Jake Jones is born in Epps, LA. |
| Saturday, November 27 |
| Future Red Sox Johnny Schmitz is born in Wausau, WI. |
| Monday, December 6 |
| Future Red Sox Gus Niarhos is born in Birmingham, AL. |
| Tuesday, December 21 |
| Future Red Sox Bill Werle is born in Oakland, CA. |
Game information provided by Retrosheet (www.retrosheet.org) |
