| Tuesday, January 6 |
| Future Indian Early Wynn is born in Hartford, AL. |
| Wednesday, January 7 |
| Future Indian Dixie Howell is born in Bowman, KY. |
| Thursday, January 15 |
| Future Indian Steve Gromek is born in Hamtramck, MI. |
| Wednesday, April 14 |
| » Defeated Browns (0-1), 5-0 | League Park II (1-0) | 1-0 | |
| » Starters: Allen Sothoron vs Stan Coveleski | First | -- |
| Saturday, April 17 |
| » Lost to Browns (1-1), 5-4 | League Park II (1-1) | 1-1 | |
| » Starters: Urban Shocker vs George Uhle | Second | 1 out |
| Sunday, April 18 |
| » Defeated Tigers (0-3), 11-4 | League Park II (2-1) | 2-1 | |
| » Starters: Doc Ayers vs Stan Coveleski | Second | ½ out |
| Monday, April 19 |
| » Defeated Tigers (0-4), 7-6 | League Park II (3-1) | 3-1 | Won 2 |
| » Starters: Red Oldham vs Jim Bagby | Third | 1 out |
| Tuesday, April 20 |
| » Defeated Tigers (0-5), 11-10 | League Park II (4-1) | 4-1 | Won 3 |
| » Starters: Ernie Alten vs Ray Caldwell | Third | 1 out |
| » Major-league debuts: Sammy Hale (Tigers) |
| Thursday, April 22 |
| » Defeated Browns (1-3), 11-3 | Sportsman's Park III (1-0) | 5-1 | Won 4 |
| » Starters: Stan Coveleski vs Urban Shocker | Second | 1 out |
| Saturday, April 24 |
| » Defeated Browns (1-4), 10-1 | Sportsman's Park III (2-0) | 6-1 | Won 5 |
| » Starters: Jim Bagby vs Dixie Davis | Third | 1 out |
| Sunday, April 25 |
| » Lost to Browns (2-4), 4-1 | Sportsman's Park III (2-1) | 6-2 | |
| » Starters: Dick Niehaus vs Allen Sothoron | Third | 1 out |
| Tuesday, April 27 |
| » Defeated White Sox (6-1), 3-2 | League Park II (5-1) | 7-2 | |
| » Starters: Red Faber vs Stan Coveleski | Third | 1 out |
| Wednesday, April 28 |
| » Defeated White Sox (6-2), 5-4 | League Park II (6-1) | 8-2 | Won 2 |
| » Starters: Dickie Kerr vs Jim Bagby | First | -- |
| Thursday, April 29 |
| » Lost to White Sox (7-2), 6-1 | League Park II (6-2) | 8-3 | |
| » Starters: Lefty Williams vs Elmer Myers | Third | 1 out |
| Saturday, May 1 |
| » Defeated Tigers (0-12), 9-3 | Tiger Stadium (1-0) | 9-3 | |
| » Starters: Stan Coveleski vs Howard Ehmke | Third | 1 out |
| Former Indian Joe Leonard dies in Washington, DC at the age of 26. |
| Sunday, May 2 |
| » Defeated Tigers (0-13), 5-2 | Tiger Stadium (2-0) | 10-3 | Won 2 |
| » Starters: Jim Bagby vs Red Oldham | Second | 1 out |
| Monday, May 3 |
| » Lost to Tigers (1-13), 5-1 | Tiger Stadium (2-1) | 10-4 | |
| » Starters: Guy Morton vs Dutch Leonard | Third | 1 out |
| Tuesday, May 4 |
| » Lost to Tigers (2-13), 2-1 | Tiger Stadium (2-2) | 10-5 | Lost 2 |
| » Starters: Elmer Myers vs Hooks Dauss | Third | 1 out |
| Wednesday, May 5 |
| » Defeated White Sox (10-4), 3-2 | Comiskey Park I (1-0) | 11-5 | |
| » Starters: Stan Coveleski vs Red Faber | Third | 1 out |
| Thursday, May 6 |
| » Defeated White Sox (10-5), 3-2 | Comiskey Park I (2-0) | 12-5 | Won 2 |
| » Starters: Jim Bagby vs Roy Wilkinson | Second | ½ out |
| Friday, May 7 |
| » Lost to White Sox (11-5), 6-1 | Comiskey Park I (2-1) | 12-6 | |
| » Starters: Ray Caldwell vs Lefty Williams | Third | 1 out |
| Saturday, May 8 |
| » Defeated White Sox (11-6), 10-6 | Comiskey Park I (3-1) | 13-6 | |
| » Starters: Elmer Myers vs Red Faber | First | -- |
| Sunday, May 9 |
| » Defeated White Sox (11-7), 4-3 | Comiskey Park I (4-1) | 14-6 | Won 2 |
| » Starters: Stan Coveleski vs Eddie Cicotte | First | -- |
| Monday, May 10 |
| » Defeated Browns (9-10), 7-3 | League Park II (7-2) | 15-6 | Won 3 |
| » Starters: Dixie Davis vs Jim Bagby | First | -- |
| Future Indian Mickey Grasso is born in Newark, NJ. |
| Wednesday, May 12 |
| » Defeated Red Sox (14-7), 9-7 | Fenway Park (1-0) | 16-6 | Won 4 |
| » Starters: Ray Caldwell vs Bullet Joe Bush | First | -- |
| Saturday, May 15 |
| » Lost to Yankees (12-11), 2-0 | Polo Grounds V (0-1) | 16-7 | |
| » Starters: Stan Coveleski vs Jack Quinn | First | -- |
| Sunday, May 16 |
| » Defeated Yankees (12-12), 8-2 | Polo Grounds V (1-1) | 17-7 | |
| » Starters: Jim Bagby vs Carl Mays | First | -- |
| Tuesday, May 18 |
| » Lost to Yankees (13-12), 11-0 | Polo Grounds V (1-2) | 17-8 | |
| » Starters: Elmer Myers vs Bob Shawkey | First | -- |
| Wednesday, May 19 |
| » Defeated Yankees (13-13), 5-0 | Polo Grounds V (2-2) | 18-8 | |
| » Starters: Stan Coveleski vs George Mogridge | First | -- |
| Thursday, May 20 |
| » Defeated Athletics (9-16), 10-4 | Shibe Park (1-0) | 19-8 | Won 2 |
| » Starters: Jim Bagby vs Walt Kinney | First | -- |
| Friday, May 21 |
| » Defeated Athletics (9-17), 9-4 | Shibe Park (2-0) | 20-8 | Won 3 |
| » Starters: Ray Caldwell vs Lyle Bigbee | First | -- |
| Saturday, May 22 |
| » Defeated Athletics (9-18), 4-1 | Shibe Park (3-0) | 21-8 | Won 4 |
| » Starters: Elmer Myers vs Scott Perry | First | -- |
| Sunday, May 23 |
| » Lost to Athletics (10-18), 2-1 | League Park II (7-3) | 21-9 | |
| » Starters: Pat Martin vs Stan Coveleski | First | -- |
| Wednesday, May 26 |
| » Lost to Senators (15-16), 13-9 | Griffith Stadium (0-1) | 21-10 | Lost 2 |
| » Starters: Ray Caldwell vs Tom Zachary | Second | ½ out |
| Friday, May 28 |
| » Defeated White Sox (18-15), 13-6 | League Park II (8-3) | 22-10 | |
| » Starters: Red Faber vs Jim Bagby | First | -- |
| Saturday, May 29 |
| » Lost to White Sox (19-15), 8-7 | League Park II (8-4) | 22-11 | |
| » Starters: Lefty Williams vs Elmer Myers | First | -- |
| » Defeated White Sox (19-16), 8-1 | League Park II (9-4) | 23-11 | |
| » Starters: Roy Wilkinson vs Ray Caldwell | First | -- |
| Sunday, May 30 |
| » Defeated White Sox (19-17), 8-6 | League Park II (10-4) | 24-11 | Won 2 |
| » Starters: Eddie Cicotte vs Joe Boehling | First | -- |
| Monday, May 31 |
| » Defeated Tigers (11-24), 9-5 | League Park II (11-4) | 25-11 | Won 3 |
| » Starters: Hooks Dauss vs Elmer Myers | First | -- |
| » Defeated Tigers (11-25), 7-3 | League Park II (12-4) | 26-11 | Won 4 |
| » Starters: Doc Ayers vs Jim Bagby | First | -- |
| Tuesday, June 1 |
| » Lost to Tigers (12-25), 11-10 | League Park II (12-5) | 26-12 | |
| » Starters: Red Oldham vs George Uhle | First | -- |
| Wednesday, June 2 |
| » Defeated Tigers (12-26), 8-5 | League Park II (13-5) | 27-12 | |
| » Starters: Bernie Boland vs Ray Caldwell | First | -- |
| Thursday, June 3 |
| » Lost to Tigers (13-26), 6-3 | League Park II (13-6) | 27-13 | |
| » Starters: Dutch Leonard vs Joe Boehling | First | -- |
| Friday, June 4 |
| » Lost to Browns (15-24), 7-6 | League Park II (13-7) | 27-14 | Lost 2 |
| » Starters: Allen Sothoron vs Jim Bagby | First | -- |
| Saturday, June 5 |
| » Lost to Browns (16-24), 6-0 | League Park II (13-8) | 27-15 | Lost 3 |
| » Starters: Urban Shocker vs Dick Niehaus | First | -- |
| Sunday, June 6 |
| » Lost to Browns (17-24), 6-2 | League Park II (13-9) | 27-16 | Lost 4 |
| » Starters: Carl Weilman vs Stan Coveleski | First | -- |
| » Defeated Browns (17-25), 2-1 | League Park II (14-9) | 28-16 | |
| » Starters: Dixie Davis vs Jim Bagby | First | -- |
| Tuesday, June 8 |
| » Defeated Athletics (16-30), 7-5 | League Park II (15-9) | 29-16 | Won 2 |
| » Starters: Roy Moore vs Ray Caldwell | First | -- |
| Wednesday, June 9 |
| » Defeated Athletics (16-31), 6-1 | League Park II (16-9) | 30-16 | Won 3 |
| » Starters: Scott Perry vs George Uhle | First | -- |
| Thursday, June 10 |
| » Defeated Athletics (16-32), 7-2 | League Park II (17-9) | 31-16 | Won 4 |
| » Starters: Bob Hasty vs Stan Coveleski | First | -- |
| Future Indian Johnny Podgajny is born in Chester, PA. |
| Friday, June 11 |
| » Defeated Athletics (16-33), 5-2 | League Park II (18-9) | 32-16 | Won 5 |
| » Starters: Roy Moore vs Jim Bagby | First | -- |
| Saturday, June 12 |
| » Defeated Yankees (33-18), 5-4 | League Park II (19-9) | 33-16 | Won 6 |
| » Starters: Jack Quinn vs Ray Caldwell | First | -- |
| Sunday, June 13 |
| » Lost to Yankees (34-18), 14-0 | League Park II (19-10) | 33-17 | |
| » Starters: Bob Shawkey vs George Uhle | First | -- |
| Monday, June 14 |
| » Defeated Yankees (34-19), 7-1 | League Park II (20-10) | 34-17 | |
| » Starters: Hank Thormahlen vs Stan Coveleski | First | -- |
| Tuesday, June 15 |
| » Defeated Yankees (34-20), 10-2 | League Park II (21-10) | 35-17 | Won 2 |
| » Starters: Carl Mays vs Jim Bagby | First | -- |
| Friday, June 18 |
| » Defeated Senators (24-26), 9-2 | League Park II (22-10) | 36-17 | Won 3 |
| » Starters: Walter Johnson vs Ray Caldwell | First | -- |
| Saturday, June 19 |
| » Lost to Senators (25-26), 5-1 | League Park II (22-11) | 36-18 | |
| » Starters: Eric Erickson vs Stan Coveleski | First | -- |
| Sunday, June 20 |
| » Lost to Red Sox (28-24), 10-9 | League Park II (22-12) | 36-19 | Lost 2 |
| » Starters: Herb Pennock vs Jim Bagby | First | -- |
| Monday, June 21 |
| » Defeated Red Sox (28-25), 3-2 | League Park II (23-12) | 37-19 | |
| » Starters: Harry Harper vs George Uhle | First | -- |
| Tuesday, June 22 |
| » Defeated Red Sox (28-26), 13-5 | League Park II (24-12) | 38-19 | Won 2 |
| » Starters: Bullet Joe Bush vs Ray Caldwell | First | -- |
| Wednesday, June 23 |
| » Defeated Red Sox (28-27), 7-6 | League Park II (25-12) | 39-19 | Won 3 |
| » Starters: Sad Sam Jones vs Guy Morton | First | -- |
| Friday, June 25 |
| » Lost to White Sox (34-25), 6-3 | Comiskey Park I (4-2) | 39-20 | |
| » Starters: Stan Coveleski vs Lefty Williams | First | -- |
| Saturday, June 26 |
| » Lost to White Sox (35-25), 12-7 | Comiskey Park I (4-3) | 39-21 | Lost 2 |
| » Starters: Ray Caldwell vs Red Faber | First | -- |
| Sunday, June 27 |
| » Defeated White Sox (35-26), 4-1 | Comiskey Park I (5-3) | 40-21 | |
| » Starters: Jim Bagby vs Dickie Kerr | First | -- |
| Monday, June 28 |
| » Defeated Browns (30-32), 7-4 | Sportsman's Park III (3-1) | 41-21 | Won 2 |
| » Starters: Stan Coveleski vs Allen Sothoron | First | -- |
| Tuesday, June 29 |
| » Defeated Browns (30-33), 9-6 | Sportsman's Park III (4-1) | 42-21 | Won 3 |
| » Starters: Ray Caldwell vs Urban Shocker | First | -- |
| » Defeated Browns (30-34), 5-4 | Sportsman's Park III (5-1) | 43-21 | Won 4 |
| » Starters: Guy Morton vs Carl Weilman | First | -- |
| Wednesday, June 30 |
| » Lost to Browns (31-34), 10-8 | Sportsman's Park III (5-2) | 43-22 | |
| » Starters: Jim Bagby vs Dixie Davis | First | -- |
| Friday, July 2 |
| » Defeated Tigers (21-44), 10-3 | Tiger Stadium (3-2) | 44-22 | |
| » Starters: Stan Coveleski vs Hooks Dauss | Second | 1½ out |
| Saturday, July 3 |
| » Defeated Tigers (21-45), 6-3 | Tiger Stadium (4-2) | 45-22 | Won 2 |
| » Starters: Jim Bagby vs Red Oldham | Second | 2 out |
| Future Indian Paul O'Dea is born in Cleveland, OH. |
| Sunday, July 4 |
| » Defeated Tigers (21-46), 11-3 | Tiger Stadium (5-2) | 46-22 | Won 3 |
| » Starters: Guy Morton vs Dutch Leonard | First | -- |
| Monday, July 5 |
| » Lost to White Sox (42-28), 5-3 | Comiskey Park I (5-4) | 46-23 | |
| » Starters: Ray Caldwell vs Lefty Williams | First | -- |
| » Lost to White Sox (43-28), 6-5 | Comiskey Park I (5-5) | 46-24 | Lost 2 |
| » Starters: Stan Coveleski vs Dickie Kerr | First | -- |
| Tuesday, July 6 |
| » Lost to White Sox (44-28), 5-4 | Comiskey Park I (5-6) | 46-25 | Lost 3 |
| » Starters: Jim Bagby vs Red Faber | Second | 2 out |
| Thursday, July 8 |
| » Defeated Senators (36-31), 4-2 | Griffith Stadium (1-1) | 47-25 | |
| » Starters: Guy Morton vs Jim Shaw | First | -- |
| » Defeated Senators (36-32), 9-6 | Griffith Stadium (2-1) | 48-25 | Won 2 |
| » Starters: Dick Niehaus vs Bill Snyder | First | -- |
| Friday, July 9 |
| » Defeated Senators (36-33), 8-4 | Griffith Stadium (3-1) | 49-25 | Won 3 |
| » Starters: Ray Caldwell vs Tom Zachary | First | -- |
| Saturday, July 10 |
| » Defeated Senators (36-34), 7-2 | Griffith Stadium (4-1) | 50-25 | Won 4 |
| » Starters: Stan Coveleski vs Bill Snyder | First | -- |
| » Lost to Senators (37-34), 2-1 | Griffith Stadium (4-2) | 50-26 | |
| » Starters: Jim Bagby vs Jim Shaw | First | -- |
| Sunday, July 11 |
| » Defeated Senators (37-35), 4-0 | Griffith Stadium (5-2) | 51-26 | |
| » Starters: Guy Morton vs Walter Johnson | First | -- |
| Tuesday, July 13 |
| » Defeated Athletics (21-60), 4-3 | Shibe Park (4-0) | 52-26 | Won 2 |
| » Starters: Ray Caldwell vs Dave Keefe | First | -- |
| Wednesday, July 14 |
| » Defeated Athletics (21-61), 5-3 | Shibe Park (5-0) | 53-26 | Won 3 |
| » Starters: Stan Coveleski vs Roy Moore | First | -- |
| Future Indian Bryan Stephens is born in Fayetteville, AR. |
| Thursday, July 15 |
| » Defeated Athletics (21-62), 5-1 | Shibe Park (6-0) | 54-26 | Won 4 |
| » Starters: Jim Bagby vs Slim Harriss | First | -- |
| Friday, July 16 |
| » Lost to Athletics (22-62), 5-4 | Shibe Park (6-1) | 54-27 | |
| » Starters: George Uhle vs Rollie Naylor | First | -- |
| Saturday, July 17 |
| » Defeated Red Sox (37-41), 5-2 | Fenway Park (2-0) | 55-27 | |
| » Starters: Ray Caldwell vs Sad Sam Jones | First | -- |
| » Defeated Red Sox (37-42), 5-2 | Fenway Park (3-0) | 56-27 | Won 2 |
| » Starters: Guy Morton vs Harry Harper | First | -- |
| Monday, July 19 |
| » Defeated Red Sox (37-43), 10-6 | Fenway Park (4-0) | 57-27 | Won 3 |
| » Starters: Stan Coveleski vs Bullet Joe Bush | First | -- |
| » Lost to Red Sox (38-43), 5-4 | Fenway Park (4-1) | 57-28 | |
| » Starters: Jim Bagby vs Herb Pennock | First | -- |
| Tuesday, July 20 |
| » Defeated Red Sox (38-44), 9-8 | Fenway Park (5-1) | 58-28 | |
| » Starters: Guy Morton vs Gary Fortune | First | -- |
| Wednesday, July 21 |
| » Lost to Yankees (59-32), 4-3 | Polo Grounds V (2-3) | 58-29 | |
| » Starters: Ray Caldwell vs Carl Mays | First | -- |
| Thursday, July 22 |
| » Lost to Yankees (60-32), 11-3 | Polo Grounds V (2-4) | 58-30 | Lost 2 |
| » Starters: Stan Coveleski vs Rip Collins | First | -- |
| Friday, July 23 |
| » Lost to Yankees (61-32), 6-3 | Polo Grounds V (2-5) | 58-31 | Lost 3 |
| » Starters: Guy Morton vs Bob Shawkey | Second | 2 out |
| Saturday, July 24 |
| » Defeated Yankees (61-33), 4-2 | Polo Grounds V (3-5) | 59-31 | |
| » Starters: Jim Bagby vs Jack Quinn | First | -- |
| Sunday, July 25 |
| » Defeated White Sox (55-36), 7-2 | League Park II (26-12) | 60-31 | Won 2 |
| » Starters: Lefty Williams vs Stan Coveleski | First | -- |
| Monday, July 26 |
| Future Indian Eddie Bockman is born in Santa Ana, CA. |
| Tuesday, July 27 |
| » Defeated Senators (42-43), 5-4 | League Park II (27-12) | 61-31 | Won 3 |
| » Starters: Tom Zachary vs Guy Morton | First | -- |
| » Lost to Senators (43-43), 19-6 | League Park II (27-13) | 61-32 | |
| » Starters: Eric Erickson vs Ray Caldwell | First | -- |
| Wednesday, July 28 |
| » Defeated Red Sox (40-49), 8-0 | League Park II (28-13) | 62-32 | |
| » Starters: Harry Harper vs Jim Bagby | First | -- |
| Thursday, July 29 |
| » Defeated Red Sox (40-50), 9-3 | League Park II (29-13) | 63-32 | Won 2 |
| » Starters: Herb Pennock vs Stan Coveleski | First | -- |
| Friday, July 30 |
| » Defeated Red Sox (40-51), 13-4 | League Park II (30-13) | 64-32 | Won 3 |
| » Starters: Bullet Joe Bush vs Ray Caldwell | First | -- |
| Saturday, July 31 |
| » Defeated Red Sox (40-52), 2-1 | League Park II (31-13) | 65-32 | Won 4 |
| » Starters: Sad Sam Jones vs Guy Morton | First | -- |
| Sunday, August 1 |
| » Lost to Senators (45-47), 8-5 | League Park II (31-14) | 65-33 | |
| » Starters: Jim Shaw vs Jim Bagby | First | -- |
| Monday, August 2 |
| » Defeated Senators (45-48), 2-0 | League Park II (32-14) | 66-33 | |
| » Starters: Harry Courtney vs Stan Coveleski | First | -- |
| Tuesday, August 3 |
| » Defeated Senators (45-49), 10-5 | League Park II (33-14) | 67-33 | Won 2 |
| » Starters: Tom Zachary vs Ray Caldwell | First | -- |
| Future Indian Jim Hegan is born in Lynn, MA. |
| Wednesday, August 4 |
| » Lost to Senators (46-49), 11-3 | League Park II (33-15) | 67-34 | |
| » Starters: Eric Erickson vs Guy Morton | First | -- |
| Friday, August 6 |
| » Lost to Athletics (32-71), 2-1 | League Park II (33-16) | 67-35 | Lost 2 |
| » Starters: Eddie Rommel vs Stan Coveleski | First | -- |
| Saturday, August 7 |
| » Defeated Athletics (32-72), 9-1 | League Park II (34-16) | 68-35 | |
| » Starters: Slim Harriss vs Jim Bagby | First | -- |
| Sunday, August 8 |
| » Defeated Athletics (32-73), 5-0 | League Park II (35-16) | 69-35 | Won 2 |
| » Starters: Scott Perry vs Ray Caldwell | First | -- |
| Monday, August 9 |
| » Lost to Yankees (68-42), 6-3 | League Park II (35-17) | 69-36 | |
| » Starters: Bob Shawkey vs Guy Morton | First | -- |
| Wednesday, August 11 |
| » Lost to Yankees (69-42), 7-4 | League Park II (35-18) | 69-37 | Lost 2 |
| » Starters: Carl Mays vs Jim Bagby | First | -- |
| Thursday, August 12 |
| » Lost to Yankees (70-42), 5-1 | League Park II (35-19) | 69-38 | Lost 3 |
| » Starters: Jack Quinn vs Stan Coveleski | First | -- |
| Friday, August 13 |
| » Lost to Yankees (71-42), 4-3 | League Park II (35-20) | 69-39 | Lost 4 |
| » Starters: Bob Shawkey vs Ray Caldwell | First | -- |
| Saturday, August 14 |
| » Lost to Browns (53-53), 5-3 | League Park II (35-21) | 69-40 | Lost 5 |
| » Starters: Urban Shocker vs Guy Morton | First | -- |
| Sunday, August 15 |
| » Defeated Browns (53-54), 5-0 | League Park II (36-21) | 70-40 | |
| » Starters: Dixie Davis vs Bob Clark | First | -- |
| Monday, August 16 |
| » Defeated Yankees (72-44), 4-3 | Polo Grounds V (4-5) | 71-40 | Won 2 |
| » Starters: Stan Coveleski vs Carl Mays | First | -- |
| Tuesday, August 17 |
| Former Indian Ray Chapman dies in New York, NY at the age of 30. |
| Wednesday, August 18 |
| » Lost to Yankees (73-44), 4-3 | Polo Grounds V (4-6) | 71-41 | |
| » Starters: Jim Bagby vs Jack Quinn | First | -- |
| Future Indian Bob Kennedy is born in Chicago, IL. |
| Thursday, August 19 |
| » Defeated Yankees (73-45), 3-2 | Polo Grounds V (5-6) | 72-41 | |
| » Starters: Ray Caldwell vs Bob Shawkey | First | -- |
| Saturday, August 21 |
| » Lost to Red Sox (53-60), 12-0 | Fenway Park (5-2) | 72-42 | |
| » Starters: Guy Morton vs Waite Hoyt | Second | 1½ out |
| » Lost to Red Sox (54-60), 4-0 | Fenway Park (5-3) | 72-43 | Lost 2 |
| » Starters: Stan Coveleski vs Herb Pennock | Second | 1½ out |
| Monday, August 23 |
| » Defeated Red Sox (54-61), 2-1 | Fenway Park (6-3) | 73-43 | |
| » Starters: Ray Caldwell vs Sad Sam Jones | Second | 2 out |
| » Lost to Red Sox (55-61), 4-3 | Fenway Park (6-4) | 73-44 | |
| » Starters: Jim Bagby vs Harry Harper | Second | 2 out |
| Tuesday, August 24 |
| » Lost to Red Sox (56-61), 7-2 | Fenway Park (6-5) | 73-45 | Lost 2 |
| » Starters: Bob Clark vs Bullet Joe Bush | Second | 2 out |
| Wednesday, August 25 |
| » Lost to Athletics (38-81), 2-1 | Shibe Park (6-2) | 73-46 | Lost 3 |
| » Starters: Stan Coveleski vs Slim Harriss | Second | 2½ out |
| Thursday, August 26 |
| » Lost to Athletics (39-81), 3-2 | Shibe Park (6-3) | 73-47 | Lost 4 |
| » Starters: Ray Caldwell vs Dave Keefe | Second | 3½ out |
| Friday, August 27 |
| » Defeated Athletics (39-82), 15-3 | Shibe Park (7-3) | 74-47 | |
| » Starters: Jim Bagby vs Rollie Naylor | Second | 2½ out |
| Sunday, August 29 |
| » Lost to Senators (52-64), 3-2 | Griffith Stadium (5-3) | 74-48 | |
| » Starters: Stan Coveleski vs Harry Courtney | Third | 2½ out |
| Monday, August 30 |
| » Defeated Senators (52-65), 8-2 | Griffith Stadium (6-3) | 75-48 | |
| » Starters: Ray Caldwell vs Jim Shaw | Third | 1½ out |
| Tuesday, August 31 |
| » Defeated Senators (52-66), 7-1 | Griffith Stadium (7-3) | 76-48 | Won 2 |
| » Starters: Jim Bagby vs Eric Erickson | Second | ½ out |
| Wednesday, September 1 |
| » Defeated Senators (52-67), 9-5 | Griffith Stadium (8-3) | 77-48 | Won 3 |
| » Starters: Duster Mails vs Jose Acosta | First | -- |
| Friday, September 3 |
| » Lost to Tigers (49-76), 1-0 | League Park II (36-22) | 77-49 | |
| » Starters: Dutch Leonard vs Stan Coveleski | First | -- |
| Saturday, September 4 |
| » Defeated Tigers (49-77), 12-3 | League Park II (37-22) | 78-49 | |
| » Starters: Doc Ayers vs Ray Caldwell | First | -- |
| Sunday, September 5 |
| » Defeated Tigers (49-78), 4-3 | League Park II (38-22) | 79-49 | Won 2 |
| » Starters: Hooks Dauss vs Jim Bagby | First | -- |
| Future Indian Gene Bearden is born in Lexa, AR. |
| Monday, September 6 |
| » Defeated Browns (64-62), 7-2 | League Park II (39-22) | 80-49 | Won 3 |
| » Starters: Carl Weilman vs Duster Mails | First | -- |
| » Defeated Browns (64-63), 6-5 | League Park II (40-22) | 81-49 | Won 4 |
| » Starters: Dixie Davis vs Guy Morton | First | -- |
| Thursday, September 9 |
| » Defeated Yankees (83-53), 10-4 | League Park II (41-22) | 82-49 | Won 5 |
| » Starters: Jack Quinn vs Stan Coveleski | First | -- |
| Friday, September 10 |
| » Lost to Yankees (84-53), 6-1 | League Park II (41-23) | 82-50 | |
| » Starters: Bob Shawkey vs Ray Caldwell | First | -- |
| » Major-league debuts: Joe Sewell (Indians) |
| Saturday, September 11 |
| » Lost to Yankees (85-53), 6-2 | League Park II (41-24) | 82-51 | Lost 2 |
| » Starters: Hank Thormahlen vs Jim Bagby | First | -- |
| Sunday, September 12 |
| » Defeated Athletics (44-91), 5-2 | League Park II (42-24) | 83-51 | |
| » Starters: Scott Perry vs Duster Mails | Second | 2½ out |
| Monday, September 13 |
| » Defeated Athletics (44-92), 3-2 | League Park II (43-24) | 84-51 | Won 2 |
| » Starters: Rollie Naylor vs Stan Coveleski | First | -- |
| Tuesday, September 14 |
| » Lost to Athletics (45-92), 8-0 | League Park II (43-25) | 84-52 | |
| » Starters: Eddie Rommel vs Ray Caldwell | Second | 2½ out |
| Wednesday, September 15 |
| » Defeated Athletics (45-93), 14-0 | League Park II (44-25) | 85-52 | |
| » Starters: Dave Keefe vs Jim Bagby | Second | 2 out |
| Thursday, September 16 |
| » Defeated Senators (61-73), 1-0 | League Park II (45-25) | 86-52 | Won 2 |
| » Starters: Tom Zachary vs Duster Mails | First | -- |
| Friday, September 17 |
| » Defeated Senators (61-74), 9-3 | League Park II (46-25) | 87-52 | Won 3 |
| » Starters: Harry Courtney vs Stan Coveleski | First | -- |
| Saturday, September 18 |
| » Defeated Senators (61-75), 7-5 | League Park II (47-25) | 88-52 | Won 4 |
| » Starters: Eric Erickson vs Ray Caldwell | First | -- |
| Sunday, September 19 |
| » Defeated Red Sox (67-77), 2-0 | League Park II (48-25) | 89-52 | Won 5 |
| » Starters: Herb Pennock vs Jim Bagby | First | -- |
| Monday, September 20 |
| » Defeated Red Sox (67-78), 8-3 | League Park II (49-25) | 90-52 | Won 6 |
| » Starters: Bullet Joe Bush vs Duster Mails | First | -- |
| Tuesday, September 21 |
| » Defeated Red Sox (67-79), 12-1 | League Park II (50-25) | 91-52 | Won 7 |
| » Starters: Sad Sam Jones vs Stan Coveleski | First | -- |
| Wednesday, September 22 |
| » Major-league debuts: Clyde Barnhart (Pirates) |
| Future Indian Bob Lemon is born in San Bernardino, CA. |
| Thursday, September 23 |
| » Lost to White Sox (92-55), 10-3 | League Park II (50-26) | 91-53 | |
| » Starters: Dickie Kerr vs Jim Bagby | First | -- |
| Future Indian Marino Pieretti is born in Lucca, Italy. |
| Friday, September 24 |
| » Defeated White Sox (92-56), 2-0 | League Park II (51-26) | 92-53 | |
| » Starters: Red Faber vs Duster Mails | First | -- |
| Saturday, September 25 |
| » Lost to White Sox (93-56), 5-1 | League Park II (51-27) | 92-54 | |
| » Starters: Lefty Williams vs Stan Coveleski | First | -- |
| Sunday, September 26 |
| » Defeated Browns (74-73), 7-5 | Sportsman's Park III (6-2) | 93-54 | |
| » Starters: Ray Caldwell vs Carl Weilman | First | -- |
| » Major-league debuts: Marty McManus (Browns) |
| Monday, September 27 |
| » Defeated Browns (74-74), 8-4 | Sportsman's Park III (7-2) | 94-54 | Won 2 |
| » Starters: Duster Mails vs Dixie Davis | First | -- |
| Tuesday, September 28 |
| » Defeated Browns (74-75), 9-5 | Sportsman's Park III (8-2) | 95-54 | Won 3 |
| » Starters: Jim Bagby vs Bill Bayne | First | -- |
| Wednesday, September 29 |
| » Defeated Browns (74-76), 10-2 | Sportsman's Park III (9-2) | 96-54 | Won 4 |
| » Starters: Stan Coveleski vs Carl Weilman | First | -- |
| Friday, October 1 |
| » Lost to Tigers (60-91), 5-4 | Tiger Stadium (5-3) | 96-55 | |
| » Starters: Duster Mails vs Howard Ehmke | First | -- |
| » Defeated Tigers (60-92), 10-3 | Tiger Stadium (6-3) | 97-55 | |
| » Starters: Ray Caldwell vs Doc Ayers | First | -- |
| Saturday, October 2 |
| » Defeated Tigers (60-93), 10-1 | Tiger Stadium (7-3) | 98-55 | Won 2 |
| » Starters: Jim Bagby vs Red Oldham | First | -- |
| Sunday, October 3 |
| » Lost to Tigers (61-93), 6-5 | Tiger Stadium (7-4) | 98-56 | |
| » Starters: Guy Morton vs Allen Conkwright | First | -- |
| Friday, October 8 |
| Future Indian Catfish Metkovich is born in Angels Camp, CA. |
| Monday, November 8 |
| Future Indian Wally Westlake is born in Gridley, CA. |
| Wednesday, December 15 |
| Future Indian Eddie Robinson is born in Paris, TX. |
Game information provided by Retrosheet (www.retrosheet.org) |
