| Wednesday, January 1 |
| Future Senator Sherry Robertson is born in Montreal, PQ. |
| Wednesday, April 23 |
| » Defeated Athletics (0-1), 1-0 | Griffith Stadium (1-0) | 1-0 | |
| » Starters: Scott Perry vs Walter Johnson | First | -- |
| » Major-league debuts: Ike Davis (Senators) |
| Thursday, April 24 |
| » Lost to Athletics (1-1), 6-5 | Griffith Stadium (1-1) | 1-1 | |
| » Starters: Mule Watson vs Harry Harper | Fourth | 1 out |
| Friday, April 25 |
| » Major-league debuts: Dickey Kerr (White Sox) |
| Sunday, April 27 |
| » Lost to Red Sox (2-0), 8-0 | Griffith Stadium (1-2) | 1-2 | Lost 2 |
| » Starters: Sad Sam Jones vs Jim Shaw | Fourth | 1½ out |
| Monday, April 28 |
| » Lost to Red Sox (3-0), 6-5 | Griffith Stadium (1-3) | 1-3 | Lost 3 |
| » Starters: Carl Mays vs Walter Johnson | Fifth | 2½ out |
| Tuesday, April 29 |
| » Defeated Red Sox (3-1), 4-2 | Griffith Stadium (2-3) | 2-3 | |
| » Starters: Herb Pennock vs Harry Harper | Fifth | 2½ out |
| Wednesday, April 30 |
| » Lost to Red Sox (4-1), 6-1 | Griffith Stadium (2-4) | 2-4 | |
| » Starters: Ray Caldwell vs Harry Thompson | Sixth | 3½ out |
| Friday, May 2 |
| » Defeated Athletics (2-4), 7-2 | Shibe Park (1-0) | 3-4 | |
| » Starters: Jim Shaw vs Walt Kinney | Fifth | 2½ out |
| Saturday, May 3 |
| » Defeated Athletics (2-5), 9-4 | Shibe Park (2-0) | 4-4 | Won 2 |
| » Starters: Harry Harper vs Scott Perry | Fourth | 2 out |
| Sunday, May 4 |
| » Defeated Athletics (2-6), 12-6 | Griffith Stadium (3-4) | 5-4 | Won 3 |
| » Starters: Walt Kinney vs Walter Johnson | Fourth | 2 out |
| Monday, May 5 |
| » Defeated Athletics (2-7), 10-6 | Shibe Park (3-0) | 6-4 | Won 4 |
| » Starters: Jim Shaw vs Jing Johnson | Third | 1½ out |
| Tuesday, May 6 |
| » Lost to Red Sox (6-4), 2-0 | Fenway Park (0-1) | 6-5 | |
| » Starters: Harry Harper vs Ray Caldwell | Fourth | 2½ out |
| Thursday, May 8 |
| » Lost to Red Sox (7-4), 3-0 | Fenway Park (0-2) | 6-6 | Lost 2 |
| » Starters: Walter Johnson vs Sad Sam Jones | Fifth | 4 out |
| Sunday, May 11 |
| » Tied Yankees, 0-0 | Polo Grounds V (0-0) | 6-6 | |
| » Starters: Walter Johnson vs Jack Quinn | Fifth | 4 out |
| Monday, May 12 |
| » Tied Yankees, 4-4 | Polo Grounds V (0-0) | 6-6 | |
| » Starters: Jim Shaw vs Allen Russell | Fifth | 4½ out |
| Tuesday, May 13 |
| » Major-league debuts: Charlie Robertson (White Sox) |
| Wednesday, May 14 |
| » Lost to Indians (10-6), 11-2 | League Park II (0-1) | 6-7 | Lost 3 |
| » Starters: Doc Ayers vs Jim Bagby | Fifth | 5 out |
| Thursday, May 15 |
| » Lost to Indians (11-6), 6-3 | League Park II (0-2) | 6-8 | Lost 4 |
| » Starters: Harry Harper vs Johnny Enzmann | Fifth | 5 out |
| Friday, May 16 |
| Former Senator Germany Schaefer dies in Saranac Lake, NY at the age of 43. |
| Saturday, May 17 |
| » Defeated Tigers (5-13), 3-2 | Tiger Stadium (1-0) | 7-8 | |
| » Starters: Jim Shaw vs Bernie Boland | Fifth | 4½ out |
| Sunday, May 18 |
| » Defeated Tigers (5-14), 8-2 | Tiger Stadium (2-0) | 8-8 | Won 2 |
| » Starters: Walter Johnson vs Howard Ehmke | Fourth | 4½ out |
| Monday, May 19 |
| » Lost to Tigers (6-14), 6-0 | Tiger Stadium (2-1) | 8-9 | |
| » Starters: Doc Ayers vs Hooks Dauss | Fifth | 5 out |
| Wednesday, May 21 |
| » Lost to Browns (9-11), 1-0 | Sportsman's Park III (0-1) | 8-10 | Lost 2 |
| » Starters: Jim Shaw vs Urban Shocker | Sixth | 6 out |
| Thursday, May 22 |
| » Lost to Browns (10-11), 5-4 | Sportsman's Park III (0-2) | 8-11 | Lost 3 |
| » Starters: Walter Johnson vs Bert Gallia | Sixth | 7 out |
| Saturday, May 24 |
| » Lost to Browns (11-11), 2-1 | Sportsman's Park III (0-3) | 8-12 | Lost 4 |
| » Starters: Harry Harper vs Carl Weilman | Sixth | 7½ out |
| Sunday, May 25 |
| » Lost to White Sox (19-7), 6-5 | Comiskey Park I (0-1) | 8-13 | Lost 5 |
| » Starters: Jim Shaw vs Grover Lowdermilk | Seventh | 8½ out |
| Monday, May 26 |
| » Lost to White Sox (20-7), 3-2 | Comiskey Park I (0-2) | 8-14 | Lost 6 |
| » Starters: Harry Thompson vs Lefty Williams | Seventh | 9½ out |
| Tuesday, May 27 |
| » Lost to White Sox (21-7), 4-3 | Comiskey Park I (0-3) | 8-15 | Lost 7 |
| » Starters: Harry Harper vs Eddie Cicotte | Seventh | 10½ out |
| Thursday, May 29 |
| » Lost to Yankees (12-10), 5-4 | Griffith Stadium (3-5) | 8-16 | Lost 8 |
| » Starters: Allen Russell vs Jim Shaw | Seventh | 11 out |
| Friday, May 30 |
| » Lost to Yankees (13-10), 4-2 | Griffith Stadium (3-6) | 8-17 | Lost 9 |
| » Starters: Hank Thormahlen vs Dick Robertson | Seventh | 13 out |
| » Lost to Yankees (14-10), 6-2 | Griffith Stadium (3-7) | 8-18 | Lost 10 |
| » Starters: Jack Quinn vs Doc Ayers | Seventh | 13 out |
| Saturday, May 31 |
| » Lost to Yankees (15-10), 6-5 | Griffith Stadium (3-8) | 8-19 | Lost 11 |
| » Starters: Ernie Shore vs Harry Harper | Seventh | 14 out |
| Sunday, June 1 |
| » Defeated Yankees (15-11), 5-2 | Griffith Stadium (4-8) | 9-19 | |
| » Starters: Allen Russell vs Walter Johnson | Seventh | 13 out |
| Monday, June 2 |
| » Defeated Red Sox (12-16), 4-0 | Griffith Stadium (5-8) | 10-19 | Won 2 |
| » Starters: Carl Mays vs Jim Shaw | Seventh | 11½ out |
| Tuesday, June 3 |
| » Lost to Red Sox (13-16), 4-3 | Griffith Stadium (5-9) | 10-20 | |
| » Starters: Ray Caldwell vs Harry Harper | Seventh | 11½ out |
| Wednesday, June 4 |
| » Lost to Red Sox (14-16), 8-3 | Griffith Stadium (5-10) | 10-21 | Lost 2 |
| » Starters: Bill James vs Dick Robertson | Seventh | 12 out |
| Thursday, June 5 |
| » Defeated Browns (16-17), 6-1 | Griffith Stadium (6-10) | 11-21 | |
| » Starters: Carl Weilman vs Walter Johnson | Seventh | 12 out |
| Friday, June 6 |
| » Defeated Browns (16-18), 7-1 | Griffith Stadium (7-10) | 12-21 | Won 2 |
| » Starters: Dave Davenport vs Jim Shaw | Seventh | 11½ out |
| Saturday, June 7 |
| » Lost to Browns (17-18), 8-0 | Griffith Stadium (7-11) | 12-22 | |
| » Starters: Urban Shocker vs Harry Harper | Seventh | 11½ out |
| Sunday, June 8 |
| » Lost to Browns (18-18), 2-1 | Griffith Stadium (7-12) | 12-23 | Lost 2 |
| » Starters: Bert Gallia vs Walter Johnson | Sixth | 11½ out |
| Tuesday, June 10 |
| » Lost to Indians (24-14), 3-2 | Griffith Stadium (7-13) | 12-24 | Lost 3 |
| » Starters: Jim Bagby vs Jim Shaw | Sixth | 12½ out |
| Wednesday, June 11 |
| » Defeated Indians (24-15), 6-3 | Griffith Stadium (8-13) | 13-24 | |
| » Starters: George Uhle vs Harry Harper | Seventh | 12½ out |
| Thursday, June 12 |
| » Lost to Indians (25-15), 5-1 | Griffith Stadium (8-14) | 13-25 | |
| » Starters: Stan Coveleski vs Doc Ayers | Seventh | 12 out |
| Friday, June 13 |
| » Defeated Indians (25-16), 1-0 | Griffith Stadium (9-14) | 14-25 | |
| » Starters: Guy Morton vs Walter Johnson | Seventh | 11 out |
| Saturday, June 14 |
| » Defeated Tigers (19-22), 7-5 | Griffith Stadium (10-14) | 15-25 | Won 2 |
| » Starters: Dutch Leonard vs Jim Shaw | Seventh | 11 out |
| Sunday, June 15 |
| » Lost to Tigers (20-22), 8-5 | Griffith Stadium (10-15) | 15-26 | |
| » Starters: Howard Ehmke vs Doc Ayers | Seventh | 12 out |
| Monday, June 16 |
| » Lost to Tigers (21-22), 3-1 | Griffith Stadium (10-16) | 15-27 | Lost 2 |
| » Starters: Bernie Boland vs Harry Harper | Seventh | 13 out |
| Tuesday, June 17 |
| » Defeated Tigers (21-23), 2-1 | Griffith Stadium (11-16) | 16-27 | |
| » Starters: Slim Love vs Walter Johnson | Seventh | 13 out |
| Wednesday, June 18 |
| » Defeated White Sox (30-16), 2-0 | Griffith Stadium (12-16) | 17-27 | Won 2 |
| » Starters: Eddie Cicotte vs Jim Shaw | Sixth | 12 out |
| Thursday, June 19 |
| » Lost to White Sox (31-16), 5-4 | Griffith Stadium (12-17) | 17-28 | |
| » Starters: Grover Lowdermilk vs Charlie Whitehouse | Sixth | 13 out |
| Friday, June 20 |
| » Lost to White Sox (32-16), 5-2 | Griffith Stadium (12-18) | 17-29 | Lost 2 |
| » Starters: Lefty Williams vs Harry Harper | Seventh | 14 out |
| Saturday, June 21 |
| » Defeated White Sox (32-17), 6-3 | Griffith Stadium (13-18) | 18-29 | |
| » Starters: Red Faber vs Walter Johnson | Seventh | 13 out |
| Sunday, June 22 |
| » Lost to Athletics (13-33), 8-4 | Griffith Stadium (13-19) | 18-30 | |
| » Starters: Rollie Naylor vs Jim Shaw | Seventh | 12½ out |
| Monday, June 23 |
| » Defeated Red Sox (20-26), 12-3 | Fenway Park (1-2) | 19-30 | |
| » Starters: Harry Harper vs Ray Caldwell | Seventh | 12½ out |
| Tuesday, June 24 |
| » Lost to Red Sox (21-26), 5-2 | Fenway Park (1-3) | 19-31 | |
| » Starters: Dick Robertson vs Ray Caldwell | Seventh | 13½ out |
| Wednesday, June 25 |
| » Defeated Red Sox (21-27), 8-3 | Fenway Park (2-3) | 20-31 | |
| » Starters: Jim Shaw vs Babe Ruth | Seventh | 14 out |
| » Lost to Red Sox (22-27), 1-0 | Fenway Park (2-4) | 20-32 | |
| » Starters: Walter Johnson vs Sad Sam Jones | Seventh | 14 out |
| Thursday, June 26 |
| » Defeated Red Sox (22-28), 3-1 | Fenway Park (3-4) | 21-32 | |
| » Starters: Harry Harper vs Herb Pennock | Seventh | 13½ out |
| Friday, June 27 |
| Former Senator Larry Schlafly dies in Canton, OH at the age of 41. |
| Saturday, June 28 |
| » Defeated Athletics (13-37), 4-1 | Shibe Park (4-0) | 22-32 | Won 2 |
| » Starters: Jim Shaw vs Jing Johnson | Seventh | 12½ out |
| » Defeated Athletics (13-38), 6-3 | Shibe Park (5-0) | 23-32 | Won 3 |
| » Starters: Eric Erickson vs Scott Perry | Seventh | 12½ out |
| Sunday, June 29 |
| » Defeated Athletics (13-39), 1-0 | Griffith Stadium (14-19) | 24-32 | Won 4 |
| » Starters: Rollie Naylor vs Walter Johnson | Seventh | 11½ out |
| Monday, June 30 |
| » Lost to Athletics (14-39), 4-3 | Shibe Park (5-1) | 24-33 | |
| » Starters: Dick Robertson vs Tom Rogers | Seventh | 13 out |
| Tuesday, July 1 |
| » Lost to Yankees (36-18), 1-0 | Griffith Stadium (14-20) | 24-34 | Lost 2 |
| » Starters: Allen Russell vs Harry Harper | Seventh | 14 out |
| Wednesday, July 2 |
| » Defeated Yankees (36-19), 6-4 | Griffith Stadium (15-20) | 25-34 | |
| » Starters: Hank Thormahlen vs Jim Shaw | Seventh | 13 out |
| Thursday, July 3 |
| » Defeated Yankees (36-20), 1-0 | Griffith Stadium (16-20) | 26-34 | Won 2 |
| » Starters: Ernie Shore vs Walter Johnson | Seventh | 12 out |
| Friday, July 4 |
| » Lost to Yankees (37-20), 8-2 | Polo Grounds V (0-1) | 26-35 | |
| » Starters: Eric Erickson vs Bob Shawkey | Seventh | 14 out |
| » Lost to Yankees (38-20), 6-5 | Polo Grounds V (0-2) | 26-36 | Lost 2 |
| » Starters: Harry Harper vs Jack Quinn | Seventh | 14 out |
| Saturday, July 5 |
| » Lost to Yankees (39-20), 6-4 | Polo Grounds V (0-3) | 26-37 | Lost 3 |
| » Starters: Molly Craft vs Pete Schneider | Seventh | 14 out |
| » Defeated Yankees (39-21), 11-5 | Polo Grounds V (1-3) | 27-37 | |
| » Starters: Jim Shaw vs Allen Russell | Seventh | 14 out |
| Sunday, July 6 |
| » Defeated Yankees (39-22), 3-1 | Polo Grounds V (2-3) | 28-37 | Won 2 |
| » Starters: Walter Johnson vs Allen Russell | Seventh | 13 out |
| Monday, July 7 |
| » Lost to Yankees (40-22), 3-2 | Polo Grounds V (2-4) | 28-38 | |
| » Starters: Eric Erickson vs Ernie Shore | Seventh | 14 out |
| Wednesday, July 9 |
| » Lost to Tigers (33-32), 2-1 | Tiger Stadium (2-2) | 28-39 | Lost 2 |
| » Starters: Jim Shaw vs Bernie Boland | Sixth | 14 out |
| Thursday, July 10 |
| » Lost to Tigers (34-32), 6-5 | Tiger Stadium (2-3) | 28-40 | Lost 3 |
| » Starters: Harry Harper vs Hooks Dauss | Seventh | 15 out |
| » Defeated Tigers (34-33), 7-5 | Tiger Stadium (3-3) | 29-40 | |
| » Starters: Walter Johnson vs Dutch Leonard | Seventh | 15 out |
| Friday, July 11 |
| » Lost to Tigers (35-33), 3-1 | Tiger Stadium (3-4) | 29-41 | |
| » Starters: Harry Harper vs Slim Love | Seventh | 16 out |
| Saturday, July 12 |
| » Defeated Indians (40-31), 6-3 | League Park II (1-2) | 30-41 | |
| » Starters: Eric Erickson vs Elmer Myers | Seventh | 14½ out |
| » Defeated Indians (40-32), 5-3 | League Park II (2-2) | 31-41 | Won 2 |
| » Starters: Jim Shaw vs Guy Morton | Seventh | 14½ out |
| Sunday, July 13 |
| » Lost to Indians (41-32), 5-4 | League Park II (2-3) | 31-42 | |
| » Starters: Molly Craft vs Stan Coveleski | Sixth | 15½ out |
| Monday, July 14 |
| » Lost to Indians (42-32), 7-1 | League Park II (2-4) | 31-43 | Lost 2 |
| » Starters: Harry Harper vs Hi Jasper | Sixth | 16½ out |
| Tuesday, July 15 |
| » Defeated Indians (42-33), 3-0 | League Park II (3-4) | 32-43 | |
| » Starters: Walter Johnson vs Jim Bagby | Seventh | 16½ out |
| Wednesday, July 16 |
| » Defeated White Sox (48-27), 11-1 | Comiskey Park I (1-3) | 33-43 | Won 2 |
| » Starters: Eric Erickson vs Grover Lowdermilk | Sixth | 15½ out |
| Thursday, July 17 |
| » Defeated White Sox (48-28), 9-4 | Comiskey Park I (2-3) | 34-43 | Won 3 |
| » Starters: Jim Shaw vs Red Faber | Sixth | 14½ out |
| Friday, July 18 |
| » Lost to White Sox (49-28), 3-0 | Comiskey Park I (2-4) | 34-44 | |
| » Starters: Harry Harper vs Lefty Williams | Sixth | 15½ out |
| » Major-league debuts: John Sullivan (White Sox) |
| Saturday, July 19 |
| » Lost to White Sox (50-28), 6-5 | Comiskey Park I (2-5) | 34-45 | Lost 2 |
| » Starters: Walter Johnson vs John Sullivan | Sixth | 16½ out |
| Sunday, July 20 |
| » Lost to Browns (41-36), 6-5 | Sportsman's Park III (0-4) | 34-46 | Lost 3 |
| » Starters: Ed Gill vs Allen Sothoron | Seventh | 17 out |
| » Defeated Browns (41-37), 13-7 | Sportsman's Park III (1-4) | 35-46 | |
| » Starters: Eric Erickson vs Rasty Wright | Seventh | 17 out |
| Monday, July 21 |
| » Lost to Browns (42-37), 5-4 | Sportsman's Park III (1-5) | 35-47 | |
| » Starters: Jim Shaw vs Dave Davenport | Seventh | 18½ out |
| Tuesday, July 22 |
| » Lost to Browns (43-37), 5-0 | Sportsman's Park III (1-6) | 35-48 | Lost 2 |
| » Starters: Harry Harper vs Carl Weilman | Seventh | 18½ out |
| Thursday, July 24 |
| » Defeated Athletics (19-60), 1-0 | Griffith Stadium (17-20) | 36-48 | |
| » Starters: Walt Kinney vs Walter Johnson | Seventh | 18½ out |
| Friday, July 25 |
| » Lost to Athletics (20-60), 6-4 | Griffith Stadium (17-21) | 36-49 | |
| » Starters: Scott Perry vs Eric Erickson | Seventh | 19½ out |
| Saturday, July 26 |
| » Lost to Athletics (21-60), 4-1 | Griffith Stadium (17-22) | 36-50 | Lost 2 |
| » Starters: Jing Johnson vs Harry Harper | Seventh | 19 out |
| » Defeated Athletics (21-61), 14-2 | Griffith Stadium (18-22) | 37-50 | |
| » Starters: Rollie Naylor vs Jim Shaw | Seventh | 19 out |
| Sunday, July 27 |
| » Lost to Athletics (22-61), 3-2 | Griffith Stadium (18-23) | 37-51 | |
| » Starters: Tom Rogers vs Tom Zachary | Seventh | 19 out |
| Tuesday, July 29 |
| » Lost to Browns (46-39), 6-3 | Griffith Stadium (18-24) | 37-52 | Lost 2 |
| » Starters: Allen Sothoron vs Eric Erickson | Seventh | 19 out |
| Wednesday, July 30 |
| » Defeated Browns (46-40), 1-0 | Griffith Stadium (19-24) | 38-52 | |
| » Starters: Dave Davenport vs Jim Shaw | Seventh | 18½ out |
| Thursday, July 31 |
| » Lost to Browns (47-40), 3-2 | Griffith Stadium (19-25) | 38-53 | |
| » Starters: Urban Shocker vs Walter Johnson | Sixth | 19½ out |
| Friday, August 1 |
| » Defeated Indians (50-40), 3-2 | Griffith Stadium (20-25) | 39-53 | |
| » Starters: Jim Bagby vs Harry Harper | Sixth | 19 out |
| Saturday, August 2 |
| » Lost to Indians (51-40), 12-6 | Griffith Stadium (20-26) | 39-54 | |
| » Starters: Elmer Myers vs Eric Erickson | Fifth | 19½ out |
| Sunday, August 3 |
| » Lost to Indians (52-40), 4-0 | Griffith Stadium (20-27) | 39-55 | Lost 2 |
| » Starters: Stan Coveleski vs Jim Shaw | Seventh | 20 out |
| Tuesday, August 5 |
| » Lost to Tigers (52-41), 2-1 | Griffith Stadium (20-28) | 39-56 | Lost 3 |
| » Starters: Bernie Boland vs Walter Johnson | Sixth | 20 out |
| Wednesday, August 6 |
| » Lost to Tigers (53-41), 4-1 | Griffith Stadium (20-29) | 39-57 | Lost 4 |
| » Starters: Dutch Leonard vs Harry Harper | Seventh | 20½ out |
| Future Senator Leon Culberson is born in Halls, GA. |
| Thursday, August 7 |
| » Lost to Tigers (54-41), 4-3 | Griffith Stadium (20-30) | 39-58 | Lost 5 |
| » Starters: Howard Ehmke vs Jim Shaw | Seventh | 21 out |
| Saturday, August 9 |
| » Defeated White Sox (60-38), 11-6 | Griffith Stadium (21-30) | 40-58 | |
| » Starters: Erskine Mayer vs Walter Johnson | Seventh | 20 out |
| Future Senator Fred Sanford is born in Garfield, UT. |
| Sunday, August 10 |
| » Lost to White Sox (61-38), 1-0 | Griffith Stadium (21-31) | 40-59 | |
| » Starters: Eddie Cicotte vs Jim Shaw | Seventh | 21 out |
| Monday, August 11 |
| » Lost to White Sox (62-38), 7-4 | Griffith Stadium (21-32) | 40-60 | Lost 2 |
| » Starters: Lefty Williams vs Harry Harper | Seventh | 22 out |
| Thursday, August 14 |
| » Lost to Indians (57-43), 4-3 | League Park II (3-5) | 40-61 | Lost 3 |
| » Starters: Eric Erickson vs Hi Jasper | Seventh | 22 out |
| Friday, August 15 |
| » Defeated Indians (57-44), 3-2 | League Park II (4-5) | 41-61 | |
| » Starters: Jim Shaw vs Elmer Myers | Sixth | 22 out |
| Sunday, August 17 |
| » Defeated Tigers (59-43), 4-2 | Tiger Stadium (4-4) | 42-61 | Won 2 |
| » Starters: Walter Johnson vs Dutch Leonard | Seventh | 22½ out |
| Monday, August 18 |
| » Lost to Tigers (60-43), 4-3 | Tiger Stadium (4-5) | 42-62 | |
| » Starters: Jim Shaw vs Bernie Boland | Seventh | 23½ out |
| Tuesday, August 19 |
| » Lost to Tigers (61-43), 7-2 | Tiger Stadium (4-6) | 42-63 | Lost 2 |
| » Starters: Harry Harper vs Hooks Dauss | Seventh | 24½ out |
| Wednesday, August 20 |
| » Lost to White Sox (68-39), 10-3 | Comiskey Park I (2-6) | 42-64 | Lost 3 |
| » Starters: Eric Erickson vs Eddie Cicotte | Seventh | 25½ out |
| Future Senator Earl Harrist is born in Dubach, LA. |
| Thursday, August 21 |
| » Lost to White Sox (69-39), 11-4 | Comiskey Park I (2-7) | 42-65 | Lost 4 |
| » Starters: Tom Zachary vs Lefty Williams | Seventh | 26½ out |
| Friday, August 22 |
| » Lost to White Sox (70-39), 3-0 | Comiskey Park I (2-8) | 42-66 | Lost 5 |
| » Starters: Jim Shaw vs Bill James | Seventh | 27½ out |
| Saturday, August 23 |
| » Lost to Browns (58-50), 11-4 | Sportsman's Park III (1-7) | 42-67 | Lost 6 |
| » Starters: Harry Harper vs Bert Gallia | Seventh | 28½ out |
| Sunday, August 24 |
| » Defeated Browns (58-51), 5-0 | Sportsman's Park III (2-7) | 43-67 | |
| » Starters: Tom Zachary vs Lefty Leifield | Seventh | 28½ out |
| Monday, August 25 |
| » Lost to Browns (59-51), 4-3 | Sportsman's Park III (2-8) | 43-68 | |
| » Starters: Jim Shaw vs Urban Shocker | Seventh | 28½ out |
| Thursday, August 28 |
| » Lost to Yankees (59-51), 5-4 | Polo Grounds V (2-5) | 43-69 | Lost 2 |
| » Starters: Walter Johnson vs Carl Mays | Seventh | 30½ out |
| » Lost to Yankees (60-51), 5-3 | Polo Grounds V (2-6) | 43-70 | Lost 3 |
| » Starters: Harry Harper vs George Mogridge | Seventh | 30½ out |
| » Major-league debuts: Frank Ellerbe and Bucky Harris (Senators) |
| Friday, August 29 |
| » Lost to Yankees (61-51), 4-1 | Polo Grounds V (2-7) | 43-71 | Lost 4 |
| » Starters: Eric Erickson vs Jack Quinn | Sixth | 32 out |
| » Lost to Yankees (62-51), 5-1 | Polo Grounds V (2-8) | 43-72 | Lost 5 |
| » Starters: Jim Shaw vs Hank Thormahlen | Sixth | 32 out |
| Sunday, August 31 |
| » Defeated Red Sox (53-62), 6-2 | Griffith Stadium (22-32) | 44-72 | |
| » Starters: Sad Sam Jones vs Tom Zachary | Seventh | 30½ out |
| Monday, September 1 |
| » Lost to Red Sox (54-62), 2-1 | Fenway Park (3-5) | 44-73 | |
| » Starters: Harry Harper vs Babe Ruth | Seventh | 32½ out |
| » Lost to Red Sox (55-62), 4-1 | Fenway Park (3-6) | 44-74 | Lost 2 |
| » Starters: Jim Shaw vs Allen Russell | Seventh | 32½ out |
| Tuesday, September 2 |
| » Lost to Athletics (31-85), 4-2 | Shibe Park (5-2) | 44-75 | Lost 3 |
| » Starters: Eric Erickson vs Walt Kinney | Seventh | 32½ out |
| Wednesday, September 3 |
| » Defeated Athletics (31-86), 4-3 | Shibe Park (6-2) | 45-75 | |
| » Starters: Ed Gill vs Jing Johnson | Seventh | 32 out |
| Thursday, September 4 |
| » Defeated Athletics (31-87), 8-2 | Shibe Park (7-2) | 46-75 | Won 2 |
| » Starters: Walter Johnson vs Jimmy Zinn | Seventh | 32 out |
| » Lost to Athletics (32-87), 6-3 | Shibe Park (7-3) | 46-76 | |
| » Starters: Harry Harper vs Rollie Naylor | Seventh | 32 out |
| Saturday, September 6 |
| » Defeated Yankees (65-52), 4-1 | Griffith Stadium (23-32) | 47-76 | |
| » Starters: Carl Mays vs Jim Shaw | Seventh | 31½ out |
| Sunday, September 7 |
| » Lost to Yankees (66-52), 3-2 | Griffith Stadium (23-33) | 47-77 | |
| » Starters: Bob Shawkey vs Eric Erickson | Seventh | 32½ out |
| Tuesday, September 9 |
| » Lost to White Sox (80-44), 2-0 | Griffith Stadium (23-34) | 47-78 | Lost 2 |
| » Starters: Bill James vs Walter Johnson | Seventh | 33½ out |
| Thursday, September 11 |
| » Defeated White Sox (80-45), 4-3 | Griffith Stadium (24-34) | 48-78 | |
| » Starters: Dickie Kerr vs Jim Shaw | Seventh | 33½ out |
| » Lost to White Sox (81-45), 5-0 | Griffith Stadium (24-35) | 48-79 | |
| » Starters: Lefty Williams vs Tom Zachary | Seventh | 33½ out |
| Friday, September 12 |
| » Defeated Tigers (72-55), 4-0 | Griffith Stadium (25-35) | 49-79 | |
| » Starters: Bernie Boland vs Eric Erickson | Seventh | 33½ out |
| Saturday, September 13 |
| » Defeated Tigers (72-56), 9-8 | Griffith Stadium (26-35) | 50-79 | Won 2 |
| » Starters: Dutch Leonard vs Harry Courtney | Seventh | 33½ out |
| » Major-league debuts: Henry Courtney (Senators) |
| Sunday, September 14 |
| » Lost to Tigers (73-56), 9-4 | Griffith Stadium (26-36) | 50-80 | |
| » Starters: Howard Ehmke vs Tom Zachary | Seventh | 34 out |
| Tuesday, September 16 |
| » Defeated Browns (64-66), 5-3 | Griffith Stadium (27-36) | 51-80 | |
| » Starters: Lefty Leifield vs Walter Johnson | Seventh | 34 out |
| Wednesday, September 17 |
| » Major-league debuts: Curt Walker (Yankees) |
| Thursday, September 18 |
| » Defeated Browns (64-67), 12-3 | Griffith Stadium (28-36) | 52-80 | Won 2 |
| » Starters: Allen Sothoron vs Al Schacht | Seventh | 33½ out |
| » Defeated Browns (64-68), 7-0 | Griffith Stadium (29-36) | 53-80 | Won 3 |
| » Starters: Bert Gallia vs Harry Courtney | Seventh | 33½ out |
| » Major-league debuts: Al Schacht (Senators) Elam Vangilder (Browns) |
| Friday, September 19 |
| » Lost to Indians (80-52), 12-3 | Griffith Stadium (29-37) | 53-81 | |
| » Starters: Jim Bagby vs Jim Shaw | Seventh | 34½ out |
| Saturday, September 20 |
| » Lost to Indians (81-52), 6-3 | Griffith Stadium (29-38) | 53-82 | Lost 2 |
| » Starters: Stan Coveleski vs Bill Snyder | Seventh | 34½ out |
| » Lost to Indians (82-52), 3-1 | Griffith Stadium (29-39) | 53-83 | Lost 3 |
| » Starters: Elmer Myers vs Tom Zachary | Seventh | 34½ out |
| Sunday, September 21 |
| » Lost to Indians (83-52), 8-4 | Griffith Stadium (29-40) | 53-84 | Lost 4 |
| » Starters: Ray Caldwell vs Jim Shaw | Seventh | 35 out |
| Saturday, September 27 |
| » Defeated Red Sox (66-69), 7-5 | Griffith Stadium (30-40) | 54-84 | |
| » Starters: Allen Russell vs Rip Jordan | Seventh | 33 out |
| » Defeated Red Sox (66-70), 4-1 | Griffith Stadium (31-40) | 55-84 | Won 2 |
| » Starters: Allen Russell vs Harry Courtney | Seventh | 33 out |
| Future Senator Johnny Pesky is born in Portland, OR. |
| Sunday, September 28 |
| » Defeated Red Sox (66-71), 8-7 | Griffith Stadium (32-40) | 56-84 | Won 3 |
| » Starters: Bob McGraw vs Al Schacht | Seventh | 32 out |
| Sunday, November 9 |
| Future Senator Gerry Priddy is born in Los Angeles, CA. |
| Friday, December 5 |
| Future Senator Baby Ortiz is born in Camaguey, Cuba. |
| Thursday, December 11 |
| Future Senator Merl Combs is born in Los Angeles, CA. |
| Wednesday, December 31 |
| Future Senator Tommy Byrne is born in Baltimore, MD. |
Game information provided by Retrosheet (www.retrosheet.org) |
