| Wednesday, January 29 |
| Future Indian Hank Edwards is born in Elmwood Place, OH. |
| Monday, March 17 |
| Future Indian Pete Reiser is born in St. Louis, MO. |
| Wednesday, April 23 |
| » Major-league debuts: Ike Davis (Senators) |
| Friday, April 25 |
| » Lost to Tigers (1-0), 4-2 | Tiger Stadium (0-1) | 0-1 | |
| » Starters: Stan Coveleski vs Howard Ehmke | Fifth | 1 out |
| Saturday, April 26 |
| » Defeated Tigers (1-1), 3-1 | Tiger Stadium (1-1) | 1-1 | |
| » Starters: Jim Bagby vs Bernie Boland | Third | ½ out |
| Tuesday, April 29 |
| » Defeated Browns (1-4), 2-0 | Sportsman's Park III (1-0) | 2-1 | Won 2 |
| » Starters: Guy Morton vs Allen Sothoron | Third | 1½ out |
| Wednesday, April 30 |
| » Defeated Browns (1-5), 4-2 | Sportsman's Park III (2-0) | 3-1 | Won 3 |
| » Starters: George Uhle vs Carl Weilman | Third | 1½ out |
| » Major-league debuts: George Uhle (Indians) |
| Thursday, May 1 |
| » Lost to Tigers (2-4), 8-1 | League Park II (0-1) | 3-2 | |
| » Starters: Bernie Boland vs Stan Coveleski | Third | 2 out |
| Friday, May 2 |
| » Lost to Tigers (3-4), 14-6 | League Park II (0-2) | 3-3 | Lost 2 |
| » Starters: Bill James vs Jim Bagby | Fourth | 2 out |
| Saturday, May 3 |
| » Defeated Tigers (3-5), 9-0 | League Park II (1-2) | 4-3 | |
| » Starters: Hooks Dauss vs Guy Morton | Third | 1½ out |
| Sunday, May 4 |
| » Defeated Tigers (3-6), 5-4 | League Park II (2-2) | 5-3 | Won 2 |
| » Starters: Howard Ehmke vs Stan Coveleski | Second | 1½ out |
| Tuesday, May 6 |
| » Lost to Browns (3-6), 6-3 | League Park II (2-3) | 5-4 | |
| » Starters: Dave Davenport vs Fritz Coumbe | Third | 2½ out |
| Wednesday, May 7 |
| » Defeated Browns (3-7), 4-2 | League Park II (3-3) | 6-4 | |
| » Starters: Bert Gallia vs George Uhle | Second | 2½ out |
| Thursday, May 8 |
| » Lost to White Sox (10-2), 4-1 | League Park II (3-4) | 6-5 | |
| » Starters: Eddie Cicotte vs Stan Coveleski | Fourth | 3½ out |
| Saturday, May 10 |
| » Defeated White Sox (10-3), 6-5 | League Park II (4-4) | 7-5 | |
| » Starters: Dickie Kerr vs Johnny Enzmann | Fourth | 2½ out |
| Sunday, May 11 |
| » Lost to White Sox (11-3), 10-2 | League Park II (4-5) | 7-6 | |
| » Starters: Lefty Williams vs George Uhle | Fourth | 3½ out |
| Monday, May 12 |
| » Defeated Tigers (5-9), 6-4 | Tiger Stadium (2-1) | 8-6 | |
| » Starters: Guy Morton vs Bernie Boland | Fourth | 3½ out |
| Tuesday, May 13 |
| » Defeated Tigers (5-10), 8-5 | Tiger Stadium (3-1) | 9-6 | Won 2 |
| » Starters: Fritz Coumbe vs Hooks Dauss | Third | 2½ out |
| Wednesday, May 14 |
| » Defeated Senators (6-7), 11-2 | League Park II (5-5) | 10-6 | Won 3 |
| » Starters: Doc Ayers vs Jim Bagby | Third | 2½ out |
| Thursday, May 15 |
| » Defeated Senators (6-8), 6-3 | League Park II (6-5) | 11-6 | Won 4 |
| » Starters: Harry Harper vs Johnny Enzmann | Third | 1½ out |
| Saturday, May 17 |
| » Lost to Yankees (9-4), 8-3 | League Park II (6-6) | 11-7 | |
| » Starters: Jack Quinn vs Guy Morton | Third | 2 out |
| Sunday, May 18 |
| » Defeated Yankees (9-5), 4-3 | League Park II (7-6) | 12-7 | |
| » Starters: George Mogridge vs Stan Coveleski | Third | 2 out |
| Monday, May 19 |
| » Lost to Yankees (10-5), 7-0 | League Park II (7-7) | 12-8 | |
| » Starters: Hank Thormahlen vs Jim Bagby | Third | 2½ out |
| Wednesday, May 21 |
| » Defeated Athletics (4-13), 7-2 | League Park II (8-7) | 13-8 | |
| » Starters: Scott Perry vs Guy Morton | Third | 2½ out |
| Thursday, May 22 |
| » Defeated Athletics (4-14), 3-2 | League Park II (9-7) | 14-8 | Won 2 |
| » Starters: Walt Kinney vs Stan Coveleski | Second | 2½ out |
| Saturday, May 24 |
| » Defeated Athletics (4-15), 6-2 | League Park II (10-7) | 15-8 | Won 3 |
| » Starters: Rollie Naylor vs Johnny Enzmann | Second | 2 out |
| Sunday, May 25 |
| » Defeated Red Sox (9-12), 3-2 | League Park II (11-7) | 16-8 | Won 4 |
| » Starters: Carl Mays vs Jim Bagby | Second | 2 out |
| Monday, May 26 |
| » Defeated Red Sox (9-13), 12-7 | League Park II (12-7) | 17-8 | Won 5 |
| » Starters: Babe Ruth vs Guy Morton | Second | 2 out |
| Tuesday, May 27 |
| » Defeated Red Sox (9-14), 6-4 | League Park II (13-7) | 18-8 | Won 6 |
| » Starters: Sad Sam Jones vs Tom Phillips | Second | 2 out |
| Friday, May 30 |
| » Lost to White Sox (22-7), 4-1 | Comiskey Park I (0-1) | 18-9 | |
| » Starters: Jim Bagby vs Red Faber | Second | 4 out |
| » Lost to White Sox (23-7), 3-2 | Comiskey Park I (0-2) | 18-10 | Lost 2 |
| » Starters: Stan Coveleski vs Lefty Williams | Second | 4 out |
| Saturday, May 31 |
| » Lost to White Sox (24-7), 5-2 | Comiskey Park I (0-3) | 18-11 | Lost 3 |
| » Starters: Tom Phillips vs Eddie Cicotte | Second | 5 out |
| » Major-league debuts: Harvey McClellan (White Sox) |
| Sunday, June 1 |
| » Defeated White Sox (24-8), 5-3 | Comiskey Park I (1-3) | 19-11 | |
| » Starters: Jim Bagby vs Dickie Kerr | Second | 4 out |
| Monday, June 2 |
| » Defeated Browns (15-15), 6-3 | League Park II (14-7) | 20-11 | Won 2 |
| » Starters: Dave Davenport vs Stan Coveleski | Second | 2½ out |
| Tuesday, June 3 |
| » Lost to Browns (16-15), 14-6 | League Park II (14-8) | 20-12 | |
| » Starters: Carl Weilman vs Charlie Jamieson | Second | 2 out |
| » Defeated Browns (16-16), 8-5 | League Park II (15-8) | 21-12 | |
| » Starters: Allen Sothoron vs Guy Morton | Second | 2 out |
| Thursday, June 5 |
| » Lost to Athletics (7-24), 10-6 | Shibe Park (0-1) | 21-13 | |
| » Starters: Jim Bagby vs Jing Johnson | Second | 3 out |
| Saturday, June 7 |
| » Defeated Athletics (7-25), 3-2 | Shibe Park (1-1) | 22-13 | |
| » Starters: Stan Coveleski vs Tom Rogers | Second | 2 out |
| Sunday, June 8 |
| » Defeated Athletics (7-26), 2-1 | League Park II (16-8) | 23-13 | Won 2 |
| » Starters: Rollie Naylor vs Guy Morton | Second | 1 out |
| Monday, June 9 |
| » Lost to Athletics (8-26), 3-1 | Shibe Park (1-2) | 23-14 | |
| » Starters: Johnny Enzmann vs Socks Seibold | Third | 1½ out |
| Tuesday, June 10 |
| » Defeated Senators (12-24), 3-2 | Griffith Stadium (1-0) | 24-14 | |
| » Starters: Jim Bagby vs Jim Shaw | Third | 1½ out |
| Wednesday, June 11 |
| » Lost to Senators (13-24), 6-3 | Griffith Stadium (1-1) | 24-15 | |
| » Starters: George Uhle vs Harry Harper | Third | 2½ out |
| Thursday, June 12 |
| » Defeated Senators (13-25), 5-1 | Griffith Stadium (2-1) | 25-15 | |
| » Starters: Stan Coveleski vs Doc Ayers | Third | 2 out |
| Friday, June 13 |
| » Lost to Senators (14-25), 1-0 | Griffith Stadium (2-2) | 25-16 | |
| » Starters: Guy Morton vs Walter Johnson | Third | 2 out |
| Saturday, June 14 |
| » Defeated Red Sox (18-20), 3-2 | Fenway Park (1-0) | 26-16 | |
| » Starters: Jim Bagby vs Babe Ruth | Third | 2 out |
| Monday, June 16 |
| » Defeated Red Sox (18-21), 1-0 | Fenway Park (2-0) | 27-16 | Won 2 |
| » Starters: Stan Coveleski vs Carl Mays | Third | 1½ out |
| Tuesday, June 17 |
| » Defeated Red Sox (18-22), 4-3 | Fenway Park (3-0) | 28-16 | Won 3 |
| » Starters: Guy Morton vs Herb Pennock | Third | 1 out |
| » Defeated Red Sox (18-23), 3-2 | Fenway Park (4-0) | 29-16 | Won 4 |
| » Starters: Tom Phillips vs Sad Sam Jones | Third | 1 out |
| Wednesday, June 18 |
| » Defeated Yankees (27-15), 13-3 | Polo Grounds V (1-0) | 30-16 | Won 5 |
| » Starters: Jim Bagby vs Hank Thormahlen | First | -- |
| Thursday, June 19 |
| » Defeated Yankees (27-16), 4-3 | Polo Grounds V (2-0) | 31-16 | Won 6 |
| » Starters: Stan Coveleski vs Jack Quinn | First | -- |
| Saturday, June 21 |
| » Lost to Yankees (28-16), 2-1 | Polo Grounds V (2-1) | 31-17 | |
| » Starters: Guy Morton vs Hank Thormahlen | Second | ½ out |
| Sunday, June 22 |
| » Lost to Browns (24-24), 3-0 | League Park II (16-9) | 31-18 | Lost 2 |
| » Starters: Allen Sothoron vs George Uhle | Third | 2 out |
| Monday, June 23 |
| » Defeated White Sox (32-19), 3-2 | Comiskey Park I (2-3) | 32-18 | |
| » Starters: Jim Bagby vs Eddie Cicotte | Second | 2 out |
| Tuesday, June 24 |
| » Defeated White Sox (32-20), 2-0 | Comiskey Park I (3-3) | 33-18 | Won 2 |
| » Starters: Stan Coveleski vs Lefty Williams | Second | 2 out |
| Wednesday, June 25 |
| » Lost to White Sox (33-20), 7-1 | Comiskey Park I (3-4) | 33-19 | |
| » Starters: Guy Morton vs Grover Lowdermilk | Second | 2 out |
| Thursday, June 26 |
| » Lost to Tigers (26-26), 1-0 | Tiger Stadium (3-2) | 33-20 | Lost 2 |
| » Starters: Hi Jasper vs Bernie Boland | Second | 2½ out |
| Friday, June 27 |
| » Lost to Tigers (27-26), 6-1 | Tiger Stadium (3-3) | 33-21 | Lost 3 |
| » Starters: Jim Bagby vs Hooks Dauss | Second | 3 out |
| Saturday, June 28 |
| » Lost to Tigers (28-26), 3-1 | Tiger Stadium (3-4) | 33-22 | Lost 4 |
| » Starters: Stan Coveleski vs Dutch Leonard | Third | 2½ out |
| Sunday, June 29 |
| » Lost to Tigers (29-26), 4-0 | Tiger Stadium (3-5) | 33-23 | Lost 5 |
| » Starters: Guy Morton vs Howard Ehmke | Third | 2½ out |
| Monday, June 30 |
| » Lost to White Sox (35-23), 5-2 | League Park II (16-10) | 33-24 | Lost 6 |
| » Starters: Eddie Cicotte vs Jim Bagby | Third | 4 out |
| Tuesday, July 1 |
| » Defeated White Sox (35-24), 14-9 | League Park II (17-10) | 34-24 | |
| » Starters: Lefty Williams vs Hi Jasper | Third | 4 out |
| Wednesday, July 2 |
| » Lost to White Sox (36-24), 6-4 | League Park II (17-11) | 34-25 | |
| » Starters: Dickie Kerr vs Stan Coveleski | Third | 4 out |
| Thursday, July 3 |
| » Lost to White Sox (37-24), 17-1 | League Park II (17-12) | 34-26 | Lost 2 |
| » Starters: Lefty Williams vs Guy Morton | Third | 4 out |
| Friday, July 4 |
| » Defeated Browns (29-30), 9-4 | League Park II (18-12) | 35-26 | |
| » Starters: Bert Gallia vs Jim Bagby | Third | 4 out |
| » Defeated Browns (29-31), 11-1 | League Park II (19-12) | 36-26 | Won 2 |
| » Starters: Rasty Wright vs Stan Coveleski | Third | 4 out |
| » Major-league debuts: Gene Robertson (Browns) |
| Saturday, July 5 |
| » Lost to Browns (30-31), 6-2 | Sportsman's Park III (2-1) | 36-27 | |
| » Starters: Hi Jasper vs Allen Sothoron | Third | 4½ out |
| Sunday, July 6 |
| » Lost to Browns (31-31), 6-3 | Sportsman's Park III (2-2) | 36-28 | Lost 2 |
| » Starters: Elmer Myers vs Carl Weilman | Third | 4½ out |
| Monday, July 7 |
| » Lost to Browns (32-31), 3-2 | Sportsman's Park III (2-3) | 36-29 | Lost 3 |
| » Starters: Guy Morton vs Urban Shocker | Third | 5½ out |
| Tuesday, July 8 |
| » Defeated Browns (32-32), 4-2 | Sportsman's Park III (3-3) | 37-29 | |
| » Starters: Jim Bagby vs Ernie Koob | Third | 5 out |
| Wednesday, July 9 |
| » Defeated Yankees (40-23), 2-0 | League Park II (20-12) | 38-29 | Won 2 |
| » Starters: Bob Shawkey vs Stan Coveleski | Third | 4 out |
| Thursday, July 10 |
| » Lost to Yankees (41-23), 1-0 | League Park II (20-13) | 38-30 | |
| » Starters: Jack Quinn vs Elmer Myers | Third | 5 out |
| » Defeated Yankees (41-24), 7-3 | League Park II (21-13) | 39-30 | |
| » Starters: Hank Thormahlen vs Hi Jasper | Third | 5 out |
| Friday, July 11 |
| » Defeated Yankees (41-25), 5-1 | League Park II (22-13) | 40-30 | Won 2 |
| » Starters: Ernie Shore vs Jim Bagby | Third | 5 out |
| Saturday, July 12 |
| » Lost to Senators (30-41), 6-3 | League Park II (22-14) | 40-31 | |
| » Starters: Eric Erickson vs Elmer Myers | Third | 5½ out |
| » Lost to Senators (31-41), 5-3 | League Park II (22-15) | 40-32 | Lost 2 |
| » Starters: Jim Shaw vs Guy Morton | Third | 5½ out |
| Sunday, July 13 |
| » Defeated Senators (31-42), 5-4 | League Park II (23-15) | 41-32 | |
| » Starters: Molly Craft vs Stan Coveleski | Third | 5½ out |
| Monday, July 14 |
| » Defeated Senators (31-43), 7-1 | League Park II (24-15) | 42-32 | Won 2 |
| » Starters: Harry Harper vs Hi Jasper | Third | 5½ out |
| Tuesday, July 15 |
| » Lost to Senators (32-43), 3-0 | League Park II (24-16) | 42-33 | |
| » Starters: Walter Johnson vs Jim Bagby | Third | 6½ out |
| Wednesday, July 16 |
| » Defeated Red Sox (31-41), 3-1 | League Park II (25-16) | 43-33 | |
| » Starters: Herb Pennock vs Elmer Myers | Third | 5½ out |
| Thursday, July 17 |
| » Defeated Red Sox (31-42), 4-0 | League Park II (26-16) | 44-33 | Won 2 |
| » Starters: Babe Ruth vs Guy Morton | Third | 4½ out |
| Friday, July 18 |
| » Lost to Red Sox (32-42), 8-7 | League Park II (26-17) | 44-34 | |
| » Starters: Ray Caldwell vs Hi Jasper | Third | 5½ out |
| Saturday, July 19 |
| » Defeated Red Sox (32-43), 7-4 | League Park II (27-17) | 45-34 | |
| » Manager: Tris Speaker |
| » Starters: Sad Sam Jones vs Stan Coveleski | Third | 5½ out |
| Sunday, July 20 |
| » Defeated Athletics (19-57), 3-2 | League Park II (28-17) | 46-34 | Won 2 |
| » Starters: Scott Perry vs Jim Bagby | Third | 5½ out |
| Monday, July 21 |
| » Defeated Athletics (19-58), 7-1 | League Park II (29-17) | 47-34 | Won 3 |
| » Starters: Tom Rogers vs Guy Morton | Second | 6 out |
| Tuesday, July 22 |
| » Defeated Athletics (19-59), 4-3 | League Park II (30-17) | 48-34 | Won 4 |
| » Starters: Rollie Naylor vs Elmer Myers | Second | 5 out |
| Thursday, July 24 |
| » Lost to Tigers (46-36), 4-2 | League Park II (30-18) | 48-35 | |
| » Starters: Bernie Boland vs Stan Coveleski | Second | 6 out |
| Friday, July 25 |
| » Lost to Tigers (47-36), 11-5 | League Park II (30-19) | 48-36 | Lost 2 |
| » Starters: Hooks Dauss vs Hi Jasper | Second | 7 out |
| Saturday, July 26 |
| » Defeated Tigers (47-37), 9-1 | League Park II (31-19) | 49-36 | |
| » Starters: Howard Ehmke vs Jim Bagby | Second | 6 out |
| Sunday, July 27 |
| » Lost to Tigers (48-37), 2-1 | League Park II (31-20) | 49-37 | |
| » Starters: Bernie Boland vs Elmer Myers | Second | 6 out |
| Tuesday, July 29 |
| » Defeated Athletics (22-62), 8-2 | Shibe Park (2-2) | 50-37 | |
| » Starters: Stan Coveleski vs Scott Perry | Third | 5½ out |
| » Lost to Athletics (23-62), 11-7 | Shibe Park (2-3) | 50-38 | |
| » Starters: Guy Morton vs Walt Kinney | Third | 5½ out |
| Wednesday, July 30 |
| » Lost to Athletics (24-62), 2-1 | Shibe Park (2-4) | 50-39 | Lost 2 |
| » Starters: Hi Jasper vs Walt Kinney | Third | 6 out |
| Friday, August 1 |
| » Lost to Senators (39-53), 3-2 | Griffith Stadium (2-3) | 50-40 | Lost 3 |
| » Starters: Jim Bagby vs Harry Harper | Third | 7 out |
| Saturday, August 2 |
| » Defeated Senators (39-54), 12-6 | Griffith Stadium (3-3) | 51-40 | |
| » Starters: Elmer Myers vs Eric Erickson | Second | 6½ out |
| Sunday, August 3 |
| » Defeated Senators (39-55), 4-0 | Griffith Stadium (4-3) | 52-40 | Won 2 |
| » Starters: Stan Coveleski vs Jim Shaw | Second | 6 out |
| Tuesday, August 5 |
| » Lost to Red Sox (42-49), 7-5 | Fenway Park (4-1) | 52-41 | |
| » Starters: Jim Bagby vs Waite Hoyt | Second | 6 out |
| Thursday, August 7 |
| » Lost to Red Sox (43-49), 8-7 | Fenway Park (4-2) | 52-42 | Lost 2 |
| » Starters: Elmer Myers vs Herb Pennock | Fourth | 6½ out |
| Friday, August 8 |
| » Defeated Red Sox (43-50), 5-4 | Fenway Park (5-2) | 53-42 | |
| » Starters: Stan Coveleski vs Sad Sam Jones | Fourth | 6 out |
| Saturday, August 9 |
| » Defeated Yankees (52-42), 6-4 | Polo Grounds V (3-1) | 54-42 | Won 2 |
| » Starters: Jim Bagby vs Bob Shawkey | Third | 5 out |
| Sunday, August 10 |
| » Lost to Yankees (53-42), 11-4 | Polo Grounds V (3-2) | 54-43 | |
| » Starters: Elmer Myers vs Carl Mays | Fourth | 6 out |
| Monday, August 11 |
| » Defeated Yankees (53-43), 15-9 | Polo Grounds V (4-2) | 55-43 | |
| » Starters: Jim Bagby vs Jack Quinn | Third | 6 out |
| Tuesday, August 12 |
| » Defeated Yankees (53-44), 2-1 | Polo Grounds V (5-2) | 56-43 | Won 2 |
| » Starters: Stan Coveleski vs George Mogridge | Third | 5½ out |
| Thursday, August 14 |
| » Defeated Senators (40-61), 4-3 | League Park II (32-20) | 57-43 | Won 3 |
| » Starters: Eric Erickson vs Hi Jasper | Third | 4½ out |
| Friday, August 15 |
| » Lost to Senators (41-61), 3-2 | League Park II (32-21) | 57-44 | |
| » Starters: Jim Shaw vs Elmer Myers | Third | 5½ out |
| Sunday, August 17 |
| » Lost to Yankees (55-46), 6-2 | League Park II (32-22) | 57-45 | Lost 2 |
| » Starters: George Mogridge vs Stan Coveleski | Third | 7 out |
| Monday, August 18 |
| » Defeated Yankees (55-47), 2-1 | League Park II (33-22) | 58-45 | |
| » Starters: Carl Mays vs Jim Bagby | Third | 7 out |
| Tuesday, August 19 |
| » Defeated Yankees (55-48), 5-1 | League Park II (34-22) | 59-45 | Won 2 |
| » Starters: Jack Quinn vs Stan Coveleski | Third | 7 out |
| Wednesday, August 20 |
| » Defeated Red Sox (48-57), 5-2 | League Park II (35-22) | 60-45 | Won 3 |
| » Starters: Sad Sam Jones vs George Uhle | Third | 7 out |
| Thursday, August 21 |
| » Lost to Red Sox (49-57), 4-3 | League Park II (35-23) | 60-46 | |
| » Starters: Herb Pennock vs Hi Jasper | Third | 8 out |
| Friday, August 22 |
| » Defeated Red Sox (49-58), 10-7 | League Park II (36-23) | 61-46 | |
| » Starters: Herb Pennock vs Jim Bagby | Third | 8 out |
| Saturday, August 23 |
| » Defeated Athletics (28-78), 6-2 | League Park II (37-23) | 62-46 | Won 2 |
| » Starters: Jing Johnson vs Stan Coveleski | Third | 8 out |
| Sunday, August 24 |
| » Defeated Athletics (28-79), 2-1 | League Park II (38-23) | 63-46 | Won 3 |
| » Starters: Rollie Naylor vs Ray Caldwell | Third | 8 out |
| Monday, August 25 |
| » Defeated Athletics (28-80), 12-0 | League Park II (39-23) | 64-46 | Won 4 |
| » Starters: Walt Kinney vs George Uhle | Third | 7 out |
| Tuesday, August 26 |
| » Defeated Tigers (65-46), 7-2 | League Park II (40-23) | 65-46 | Won 5 |
| » Starters: Bernie Boland vs Jim Bagby | Second | 7 out |
| Wednesday, August 27 |
| » Defeated Tigers (65-47), 7-5 | League Park II (41-23) | 66-46 | Won 6 |
| » Starters: Hooks Dauss vs Stan Coveleski | Second | 7 out |
| Friday, August 29 |
| » Lost to White Sox (75-40), 3-2 | League Park II (41-24) | 66-47 | |
| » Starters: Eddie Cicotte vs Ray Caldwell | Second | 8 out |
| Saturday, August 30 |
| » Defeated White Sox (75-41), 4-0 | League Park II (42-24) | 67-47 | |
| » Starters: Bill James vs Elmer Myers | Second | 7 out |
| Sunday, August 31 |
| » Defeated White Sox (75-42), 6-1 | League Park II (43-24) | 68-47 | Won 2 |
| » Starters: Lefty Williams vs Stan Coveleski | Second | 6 out |
| Monday, September 1 |
| » Defeated Browns (60-57), 5-3 | Sportsman's Park III (4-3) | 69-47 | Won 3 |
| » Starters: George Uhle vs Bert Gallia | Second | 7 out |
| » Lost to Browns (61-57), 4-3 | Sportsman's Park III (4-4) | 69-48 | |
| » Starters: Jim Bagby vs Lefty Leifield | Second | 7 out |
| Tuesday, September 2 |
| » Defeated Browns (61-58), 4-3 | Sportsman's Park III (5-4) | 70-48 | |
| » Starters: Ray Caldwell vs Urban Shocker | Second | 6 out |
| Wednesday, September 3 |
| » Lost to Browns (62-58), 6-5 | Sportsman's Park III (5-5) | 70-49 | |
| » Starters: Guy Morton vs Allen Sothoron | Second | 6½ out |
| Friday, September 5 |
| » Lost to White Sox (78-43), 9-1 | Comiskey Park I (3-5) | 70-50 | Lost 2 |
| » Starters: Elmer Myers vs Eddie Cicotte | Third | 7½ out |
| Saturday, September 6 |
| » Defeated White Sox (78-44), 11-2 | Comiskey Park I (4-5) | 71-50 | |
| » Starters: Jim Bagby vs Lefty Williams | Second | 6½ out |
| Sunday, September 7 |
| » Lost to White Sox (79-44), 8-3 | Comiskey Park I (4-6) | 71-51 | |
| » Starters: Stan Coveleski vs Dickie Kerr | Second | 7½ out |
| Monday, September 8 |
| » Major-league debuts: Hod Ford (Braves) |
| Tuesday, September 9 |
| » Major-league debuts: Al Wingo (Athletics) |
| Wednesday, September 10 |
| » Defeated Yankees (66-55), 3-0 | Polo Grounds V (6-2) | 72-51 | |
| » Starters: Ray Caldwell vs Carl Mays | Second | 7 out |
| » Defeated Yankees (66-56), 3-2 | Polo Grounds V (7-2) | 73-51 | Won 2 |
| » Starters: George Uhle vs Jack Quinn | Second | 7 out |
| Thursday, September 11 |
| » Lost to Yankees (67-56), 2-1 | Polo Grounds V (7-3) | 73-52 | |
| » Starters: Jim Bagby vs Bob Shawkey | Second | 7½ out |
| Friday, September 12 |
| » Defeated Red Sox (62-63), 4-3 | Fenway Park (6-2) | 74-52 | |
| » Starters: Stan Coveleski vs Sad Sam Jones | Second | 7½ out |
| Saturday, September 13 |
| » Defeated Red Sox (62-64), 4-3 | Fenway Park (7-2) | 75-52 | Won 2 |
| » Starters: Elmer Myers vs Waite Hoyt | Second | 7½ out |
| Tuesday, September 16 |
| » Defeated Athletics (34-95), 8-2 | Shibe Park (3-4) | 76-52 | Won 3 |
| » Starters: Stan Coveleski vs Bob Hasty | Second | 7 out |
| » Defeated Athletics (34-96), 12-8 | Shibe Park (4-4) | 77-52 | Won 4 |
| » Starters: George Uhle vs Ray Roberts | Second | 7 out |
| Wednesday, September 17 |
| » Defeated Athletics (34-97), 8-2 | Shibe Park (5-4) | 78-52 | Won 5 |
| » Starters: Ray Caldwell vs Dan Boone | Second | 7½ out |
| Thursday, September 18 |
| » Defeated Athletics (34-98), 4-1 | Shibe Park (6-4) | 79-52 | Won 6 |
| » Starters: George Uhle vs Charlie Eckert | Second | 6½ out |
| Friday, September 19 |
| » Defeated Senators (53-81), 12-3 | Griffith Stadium (5-3) | 80-52 | Won 7 |
| » Starters: Jim Bagby vs Jim Shaw | Second | 6½ out |
| Saturday, September 20 |
| » Defeated Senators (53-82), 6-3 | Griffith Stadium (6-3) | 81-52 | Won 8 |
| » Starters: Stan Coveleski vs Bill Snyder | Second | 4½ out |
| » Defeated Senators (53-83), 3-1 | Griffith Stadium (7-3) | 82-52 | Won 9 |
| » Starters: Elmer Myers vs Tom Zachary | Second | 4½ out |
| Sunday, September 21 |
| » Defeated Senators (53-84), 8-4 | Griffith Stadium (8-3) | 83-52 | Won 10 |
| » Starters: Ray Caldwell vs Jim Shaw | Second | 4 out |
| Wednesday, September 24 |
| » Lost to Tigers (76-60), 4-1 | Tiger Stadium (3-6) | 83-53 | |
| » Starters: Jim Bagby vs Dutch Leonard | Second | 5 out |
| Thursday, September 25 |
| » Lost to Tigers (77-60), 9-5 | Tiger Stadium (3-7) | 83-54 | Lost 2 |
| » Starters: Elmer Myers vs Bernie Boland | Second | 5 out |
| Saturday, September 27 |
| » Defeated Browns (66-72), 11-3 | League Park II (44-24) | 84-54 | |
| » Starters: Rasty Wright vs George Uhle | Second | 3½ out |
| Sunday, September 28 |
| » Lost to Browns (67-72), 8-5 | League Park II (44-25) | 84-55 | |
| » Starters: Bill Bayne vs Stan Coveleski | Second | 3½ out |
| Friday, October 17 |
| Future Indian Howie Moss is born in Gastonia, NC. |
| Thursday, December 11 |
| Future Indian Merl Combs is born in Los Angeles, CA. |
Game information provided by Retrosheet (www.retrosheet.org) |