| Saturday, January 20 |
| Future Red Sox Joe Dobson is born in Durant, OK. |
| Wednesday, January 24 |
| Future Red Sox Danny Doyle is born in McLoud, OK. |
| Tuesday, January 30 |
| Future Red Sox Mickey Harris is born in New York, NY. |
| Monday, February 12 |
| Future Red Sox Dom DiMaggio is born in San Francisco, CA. |
| Wednesday, April 11 |
| » Defeated Yankees (0-1), 10-3 | Polo Grounds V (1-0) | 1-0 | |
| » Starters: Babe Ruth vs Ray Caldwell | First | -- |
| Thursday, April 12 |
| » Defeated Yankees (0-2), 6-1 | Polo Grounds V (2-0) | 2-0 | Won 2 |
| » Starters: Dutch Leonard vs Bob Shawkey | First | -- |
| Friday, April 13 |
| » Major-league debuts: Jimmy Ring (Reds) |
| Saturday, April 14 |
| » Lost to Yankees (1-2), 7-2 | Polo Grounds V (2-1) | 2-1 | |
| » Starters: Herb Pennock vs George Mogridge | First | -- |
| Monday, April 16 |
| » Defeated Athletics (1-3), 6-1 | Shibe Park (1-0) | 3-1 | |
| » Starters: Babe Ruth vs Socks Seibold | Second | ½ out |
| Tuesday, April 17 |
| » Defeated Athletics (1-4), 3-1 | Shibe Park (2-0) | 4-1 | Won 2 |
| » Starters: Ernie Shore vs Bullet Joe Bush | Second | ½ out |
| Wednesday, April 18 |
| » Defeated Athletics (1-5), 2-0 | Shibe Park (3-0) | 5-1 | Won 3 |
| » Starters: Dutch Leonard vs Win Noyes | First | -- |
| Thursday, April 19 |
| » Lost to Athletics (2-5), 4-3 | Shibe Park (3-1) | 5-2 | |
| » Starters: Carl Mays vs Rube Parnham | First | -- |
| Saturday, April 21 |
| » Defeated Yankees (4-3), 6-4 | Fenway Park (1-0) | 6-2 | |
| » Starters: Bob Shawkey vs Babe Ruth | Second | ½ out |
| Monday, April 23 |
| » Lost to Yankees (5-3), 9-6 | Fenway Park (1-1) | 6-3 | |
| » Starters: Nick Cullop vs Ernie Shore | Second | 1½ out |
| Future Red Sox Tony Lupien is born in Chelmsford, MA. |
| Tuesday, April 24 |
| » Lost to Yankees (6-3), 2-1 | Fenway Park (1-2) | 6-4 | Lost 2 |
| » Starters: George Mogridge vs Dutch Leonard | Third | 2½ out |
| Wednesday, April 25 |
| » Defeated Senators (4-7), 5-4 | Fenway Park (2-2) | 7-4 | |
| » Starters: Doc Ayers vs Babe Ruth | Second | 1½ out |
| Saturday, April 28 |
| » Defeated Senators (4-8), 7-1 | Fenway Park (3-2) | 8-4 | Won 2 |
| » Starters: Walter Johnson vs Ernie Shore | Second | 1½ out |
| Monday, April 30 |
| » Defeated Athletics (6-8), 6-3 | Fenway Park (4-2) | 9-4 | Won 3 |
| » Starters: Jing Johnson vs Babe Ruth | First | -- |
| Thursday, May 3 |
| » Defeated Athletics (6-9), 2-0 | Fenway Park (5-2) | 10-4 | Won 4 |
| » Starters: Bullet Joe Bush vs Dutch Leonard | First | -- |
| Monday, May 7 |
| » Defeated Senators (6-11), 1-0 | Griffith Stadium (1-0) | 11-4 | Won 5 |
| » Starters: Babe Ruth vs Walter Johnson | First | -- |
| Future Red Sox Al Papai is born in Divernon, IL. |
| Wednesday, May 9 |
| » Defeated Senators (6-12), 4-1 | Griffith Stadium (2-0) | 12-4 | Won 6 |
| » Starters: Ernie Shore vs George Dumont | First | -- |
| » Lost to Senators (7-12), 4-3 | Griffith Stadium (2-1) | 12-5 | |
| » Starters: Carl Mays vs Jim Shaw | First | -- |
| Thursday, May 10 |
| » Defeated Tigers (8-12), 3-1 | Tiger Stadium (1-0) | 13-5 | |
| » Starters: Dutch Leonard vs Harry Coveleski | First | -- |
| Friday, May 11 |
| » Defeated Tigers (8-13), 2-1 | Tiger Stadium (2-0) | 14-5 | Won 2 |
| » Starters: Babe Ruth vs Willie Mitchell | First | -- |
| Saturday, May 12 |
| » Defeated Tigers (8-14), 8-0 | Tiger Stadium (3-0) | 15-5 | Won 3 |
| » Starters: Carl Mays vs Hooks Dauss | First | -- |
| Sunday, May 13 |
| » Lost to Tigers (9-14), 2-1 | Tiger Stadium (3-1) | 15-6 | |
| » Starters: Ernie Shore vs Howard Ehmke | First | -- |
| Future Red Sox Lou Stringer is born in Grand Rapids, MI. |
| Monday, May 14 |
| » Lost to Indians (15-13), 7-6 | League Park II (0-1) | 15-7 | Lost 2 |
| » Starters: Dutch Leonard vs Ed Klepfer | First | -- |
| Tuesday, May 15 |
| » Defeated Indians (15-14), 6-5 | League Park II (1-1) | 16-7 | |
| » Starters: Babe Ruth vs Fritz Coumbe | First | -- |
| Wednesday, May 16 |
| » Defeated Indians (15-15), 5-1 | League Park II (2-1) | 17-7 | Won 2 |
| » Starters: Carl Mays vs Jim Bagby | First | -- |
| Thursday, May 17 |
| » Lost to Indians (16-15), 7-1 | League Park II (2-2) | 17-8 | |
| » Starters: Ernie Shore vs Stan Coveleski | First | -- |
| Friday, May 18 |
| » Lost to White Sox (21-12), 8-2 | Comiskey Park I (0-1) | 17-9 | Lost 2 |
| » Starters: Babe Ruth vs Reb Russell | First | -- |
| Saturday, May 19 |
| » Lost to White Sox (22-12), 8-2 | Comiskey Park I (0-2) | 17-10 | Lost 3 |
| » Starters: Dutch Leonard vs Lefty Williams | Third | ½ out |
| Sunday, May 20 |
| » Defeated White Sox (22-13), 2-1 | Comiskey Park I (1-2) | 18-10 | |
| » Starters: Carl Mays vs Jim Scott | First | -- |
| Wednesday, May 23 |
| » Defeated Browns (15-19), 8-2 | Sportsman's Park III (1-0) | 19-10 | Won 2 |
| » Starters: Ernie Shore vs Ernie Koob | First | -- |
| Thursday, May 24 |
| » Defeated Browns (15-20), 4-3 | Sportsman's Park III (2-0) | 20-10 | Won 3 |
| » Starters: Babe Ruth vs Dave Davenport | First | -- |
| Friday, May 25 |
| » Defeated Browns (15-21), 3-0 | Sportsman's Park III (3-0) | 21-10 | Won 4 |
| » Starters: Dutch Leonard vs Bob Groom | First | -- |
| Saturday, May 26 |
| » Defeated Browns (15-22), 11-7 | Sportsman's Park III (4-0) | 22-10 | Won 5 |
| » Starters: Carl Mays vs Allen Sothoron | First | -- |
| Sunday, May 27 |
| » Tied Browns, 1-1 | Sportsman's Park III (4-0) | 22-10 | |
| » Starters: Carl Mays vs Eddie Plank | First | -- |
| Tuesday, May 29 |
| » Defeated Senators (13-22), 2-1 | Griffith Stadium (3-1) | 23-10 | Won 6 |
| » Starters: Dutch Leonard vs George Dumont | First | -- |
| » Defeated Senators (13-23), 9-0 | Griffith Stadium (4-1) | 24-10 | Won 7 |
| » Starters: Babe Ruth vs Harry Harper | First | -- |
| Wednesday, May 30 |
| » Defeated Senators (13-24), 4-3 | Griffith Stadium (5-1) | 25-10 | Won 8 |
| » Starters: Ernie Shore vs Bert Gallia | First | -- |
| » Defeated Senators (13-25), 3-2 | Griffith Stadium (6-1) | 26-10 | Won 9 |
| » Starters: King Bader vs Jim Shaw | First | -- |
| Thursday, May 31 |
| » Defeated Indians (22-21), 5-1 | Fenway Park (6-2) | 27-10 | Won 10 |
| » Starters: Joe Boehling vs Carl Mays | First | -- |
| Friday, June 1 |
| » Lost to Indians (23-21), 3-0 | Fenway Park (6-3) | 27-11 | |
| » Starters: Guy Morton vs Babe Ruth | First | -- |
| Saturday, June 2 |
| » Lost to Indians (24-21), 5-0 | Fenway Park (6-4) | 27-12 | Lost 2 |
| » Starters: Jim Bagby vs Dutch Leonard | First | -- |
| Monday, June 4 |
| » Defeated Indians (24-22), 2-1 | Fenway Park (7-4) | 28-12 | |
| » Starters: Stan Coveleski vs Ernie Shore | First | -- |
| Tuesday, June 5 |
| » Defeated Indians (24-23), 11-4 | Fenway Park (8-4) | 29-12 | Won 2 |
| » Starters: Al Gould vs Carl Mays | First | -- |
| Wednesday, June 6 |
| » Lost to Tigers (18-24), 3-0 | Fenway Park (8-5) | 29-13 | |
| » Starters: Hooks Dauss vs Babe Ruth | First | -- |
| Friday, June 8 |
| » Lost to Tigers (19-24), 7-4 | Fenway Park (8-6) | 29-14 | Lost 2 |
| » Starters: Bill James vs Dutch Leonard | Second | 1½ out |
| Saturday, June 9 |
| » Lost to Tigers (20-24), 1-0 | Fenway Park (8-7) | 29-15 | Lost 3 |
| » Starters: Howard Ehmke vs Ernie Shore | Second | 1½ out |
| Wednesday, June 13 |
| » Defeated Browns (18-28), 2-0 | Fenway Park (9-7) | 30-15 | |
| » Starters: Dave Davenport vs Babe Ruth | Second | 2 out |
| » Lost to Browns (19-28), 7-2 | Fenway Park (9-8) | 30-16 | |
| » Starters: Allen Sothoron vs Carl Mays | Second | 2 out |
| Thursday, June 14 |
| » Lost to Browns (20-28), 3-0 | Fenway Park (9-9) | 30-17 | Lost 2 |
| » Starters: Bob Groom vs Dutch Leonard | Second | 1½ out |
| Friday, June 15 |
| » Lost to White Sox (34-17), 8-0 | Fenway Park (9-10) | 30-18 | Lost 3 |
| » Starters: Lefty Williams vs Ernie Shore | Second | 2½ out |
| Saturday, June 16 |
| » Lost to White Sox (35-17), 7-2 | Fenway Park (9-11) | 30-19 | Lost 4 |
| » Starters: Eddie Cicotte vs Babe Ruth | Second | 3½ out |
| Monday, June 18 |
| » Defeated White Sox (35-18), 6-4 | Fenway Park (10-11) | 31-19 | |
| » Starters: Reb Russell vs Carl Mays | Second | 1½ out |
| » Defeated White Sox (35-19), 8-7 | Fenway Park (11-11) | 32-19 | Won 2 |
| » Starters: Jim Scott vs Rube Foster | Second | 1½ out |
| Wednesday, June 20 |
| » Lost to Yankees (29-22), 3-2 | Polo Grounds V (2-2) | 32-20 | |
| » Starters: Dutch Leonard vs George Mogridge | Second | 2 out |
| » Defeated Yankees (29-23), 3-1 | Polo Grounds V (3-2) | 33-20 | |
| » Starters: Babe Ruth vs Nick Cullop | Second | 2 out |
| Thursday, June 21 |
| » Lost to Yankees (30-23), 5-4 | Polo Grounds V (3-3) | 33-21 | |
| » Starters: Ernie Shore vs Slim Love | Second | 2 out |
| Friday, June 22 |
| » Defeated Yankees (30-24), 2-1 | Polo Grounds V (4-3) | 34-21 | |
| » Starters: Carl Mays vs Bob Shawkey | Second | 2 out |
| Saturday, June 23 |
| » Defeated Senators (21-34), 4-0 | Fenway Park (12-11) | 35-21 | Won 2 |
| » Starters: Doc Ayers vs Babe Ruth | Second | 1½ out |
| » Defeated Senators (21-35), 5-0 | Fenway Park (13-11) | 36-21 | Won 3 |
| » Starters: Walter Johnson vs Dutch Leonard | Second | 1½ out |
| Monday, June 25 |
| » Lost to Senators (22-35), 4-0 | Fenway Park (13-12) | 36-22 | |
| » Starters: Harry Harper vs Rube Foster | Second | 2 out |
| » Defeated Senators (22-36), 4-3 | Fenway Park (14-12) | 37-22 | |
| » Starters: George Dumont vs Herb Pennock | Second | 2 out |
| Tuesday, June 26 |
| » Lost to Senators (23-36), 3-2 | Fenway Park (14-13) | 37-23 | |
| » Starters: Jim Shaw vs Carl Mays | Second | 2½ out |
| Wednesday, June 27 |
| » Lost to Senators (24-36), 7-6 | Fenway Park (14-14) | 37-24 | Lost 2 |
| » Starters: Bert Gallia vs Ernie Shore | Second | 4 out |
| Thursday, June 28 |
| » Defeated Yankees (35-26), 3-2 | Fenway Park (15-14) | 38-24 | |
| » Starters: Ray Fisher vs Dutch Leonard | Second | 2½ out |
| » Defeated Yankees (35-27), 5-0 | Fenway Park (16-14) | 39-24 | Won 2 |
| » Starters: Ray Caldwell vs Herb Pennock | Second | 2½ out |
| Friday, June 29 |
| » Defeated Yankees (35-28), 2-1 | Fenway Park (17-14) | 40-24 | Won 3 |
| » Starters: George Mogridge vs Rube Foster | Second | 2½ out |
| Saturday, June 30 |
| » Defeated Yankees (35-29), 9-2 | Fenway Park (18-14) | 41-24 | Won 4 |
| » Starters: Nick Cullop vs Carl Mays | Second | 1½ out |
| Monday, July 2 |
| » Tied Yankees, 4-4 | Fenway Park (18-14) | 41-24 | |
| » Starters: George Mogridge vs Ernie Shore | Second | 1½ out |
| Tuesday, July 3 |
| » Lost to Athletics (24-39), 3-0 | Fenway Park (18-15) | 41-25 | |
| » Starters: Elmer Myers vs Babe Ruth | Second | 2 out |
| » Defeated Athletics (24-40), 6-1 | Fenway Park (19-15) | 42-25 | |
| » Starters: Win Noyes vs Dutch Leonard | Second | 2 out |
| Wednesday, July 4 |
| » Defeated Athletics (24-41), 6-3 | Fenway Park (20-15) | 43-25 | Won 2 |
| » Starters: Jing Johnson vs Herb Pennock | Second | 2 out |
| » Defeated Athletics (24-42), 6-2 | Fenway Park (21-15) | 44-25 | Won 3 |
| » Starters: Cy Falkenberg vs Rube Foster | Second | 2 out |
| Thursday, July 5 |
| » Defeated Athletics (24-43), 4-3 | Fenway Park (22-15) | 45-25 | Won 4 |
| » Starters: Bullet Joe Bush vs Carl Mays | Second | ½ out |
| » Defeated Athletics (24-44), 4-2 | Fenway Park (23-15) | 46-25 | Won 5 |
| » Starters: Socks Seibold vs Ernie Shore | Second | ½ out |
| Saturday, July 7 |
| » Lost to Indians (40-37), 3-1 | League Park II (2-3) | 46-26 | |
| » Starters: Babe Ruth vs Stan Coveleski | First | -- |
| Sunday, July 8 |
| » Lost to Indians (41-37), 1-0 | League Park II (2-4) | 46-27 | Lost 2 |
| » Starters: Dutch Leonard vs Jim Bagby | Second | 1 out |
| Monday, July 9 |
| » Lost to Indians (42-37), 4-3 | League Park II (2-5) | 46-28 | Lost 3 |
| » Starters: Carl Mays vs Ed Klepfer | Second | 1 out |
| Wednesday, July 11 |
| » Defeated Tigers (38-38), 1-0 | Tiger Stadium (4-1) | 47-28 | |
| » Starters: Babe Ruth vs Hooks Dauss | First | -- |
| Thursday, July 12 |
| » Lost to Tigers (39-38), 5-0 | Tiger Stadium (4-2) | 47-29 | |
| » Starters: Ernie Shore vs Howard Ehmke | Second | 1½ out |
| Friday, July 13 |
| » Lost to Tigers (40-38), 1-0 | Tiger Stadium (4-3) | 47-30 | Lost 2 |
| » Starters: Dutch Leonard vs Bernie Boland | Second | 1½ out |
| Saturday, July 14 |
| » Defeated Tigers (40-39), 4-1 | Tiger Stadium (5-3) | 48-30 | |
| » Starters: Carl Mays vs Bill James | Second | 1½ out |
| Sunday, July 15 |
| » Defeated Browns (31-51), 4-2 | Sportsman's Park III (5-0) | 49-30 | Won 2 |
| » Starters: Babe Ruth vs Allen Sothoron | First | -- |
| » Defeated Browns (31-52), 6-3 | Sportsman's Park III (6-0) | 50-30 | Won 3 |
| » Starters: Ernie Shore vs Tom Rogers | First | -- |
| Monday, July 16 |
| » Lost to Browns (32-52), 2-0 | Sportsman's Park III (6-1) | 50-31 | |
| » Starters: Rube Foster vs Dave Davenport | Second | ½ out |
| Tuesday, July 17 |
| » Lost to Browns (33-52), 3-2 | Sportsman's Park III (6-2) | 50-32 | Lost 2 |
| » Starters: Dutch Leonard vs Eddie Plank | Second | 2 out |
| Future Red Sox Lou Boudreau is born in Harvey, IL. |
| Wednesday, July 18 |
| » Defeated Browns (33-53), 1-0 | Sportsman's Park III (7-2) | 51-32 | |
| » Starters: Carl Mays vs Ernie Koob | Second | 2½ out |
| Thursday, July 19 |
| » Defeated White Sox (55-32), 3-2 | Comiskey Park I (2-2) | 52-32 | Won 2 |
| » Starters: Babe Ruth vs Lefty Williams | Second | 1½ out |
| Friday, July 20 |
| » Lost to White Sox (56-32), 5-2 | Comiskey Park I (2-3) | 52-33 | |
| » Starters: Rube Foster vs Eddie Cicotte | Second | 2½ out |
| Saturday, July 21 |
| » Tied White Sox, 5-5 | Comiskey Park I (2-3) | 52-33 | |
| » Starters: Dutch Leonard vs Red Faber | Second | 2½ out |
| Sunday, July 22 |
| » Lost to White Sox (57-32), 2-0 | Comiskey Park I (2-4) | 52-34 | Lost 2 |
| » Starters: Carl Mays vs Reb Russell | Second | 3½ out |
| Monday, July 23 |
| » Lost to White Sox (58-32), 5-3 | Comiskey Park I (2-5) | 52-35 | Lost 3 |
| » Starters: Ernie Shore vs Lefty Williams | Second | 4½ out |
| Future Red Sox Ray Scarborough is born in Mount Gilead, NC. |
| Wednesday, July 25 |
| » Defeated Browns (36-56), 5-4 | Fenway Park (24-15) | 53-35 | |
| » Starters: Dave Davenport vs Dutch Leonard | Second | 5 out |
| Thursday, July 26 |
| » Defeated Browns (36-57), 11-2 | Fenway Park (25-15) | 54-35 | Won 2 |
| » Starters: Ernie Koob vs Babe Ruth | Second | 3½ out |
| » Defeated Browns (36-58), 8-3 | Fenway Park (26-15) | 55-35 | Won 3 |
| » Starters: Allen Sothoron vs Rube Foster | Second | 3½ out |
| Friday, July 27 |
| Future Red Sox Bill Sayles is born in Portland, OR. |
| Saturday, July 28 |
| » Defeated Browns (36-59), 3-2 | Fenway Park (27-15) | 56-35 | Won 4 |
| » Starters: Eddie Plank vs Carl Mays | Second | 2 out |
| » Defeated Browns (36-60), 3-2 | Fenway Park (28-15) | 57-35 | Won 5 |
| » Starters: Bob Groom vs Ernie Shore | Second | 2 out |
| Monday, July 30 |
| » Defeated White Sox (61-36), 3-1 | Fenway Park (29-15) | 58-35 | Won 6 |
| » Starters: Lefty Williams vs Babe Ruth | Second | 2 out |
| Tuesday, July 31 |
| » Defeated White Sox (61-37), 5-2 | Fenway Park (30-15) | 59-35 | Won 7 |
| » Starters: Eddie Cicotte vs Dutch Leonard | First | -- |
| Wednesday, August 1 |
| » Lost to White Sox (62-37), 4-0 | Fenway Park (30-16) | 59-36 | |
| » Starters: Reb Russell vs Carl Mays | Second | 2 out |
| Thursday, August 2 |
| » Lost to White Sox (63-37), 7-1 | Fenway Park (30-17) | 59-37 | Lost 2 |
| » Starters: Red Faber vs Ernie Shore | Second | 2 out |
| Friday, August 3 |
| » Lost to Indians (55-48), 2-1 | Fenway Park (30-18) | 59-38 | Lost 3 |
| » Starters: Jim Bagby vs Babe Ruth | Second | 3 out |
| Saturday, August 4 |
| » Defeated Indians (55-49), 3-2 | Fenway Park (31-18) | 60-38 | |
| » Starters: Stan Coveleski vs Dutch Leonard | Second | 3½ out |
| Monday, August 6 |
| » Lost to Indians (56-49), 2-0 | Fenway Park (31-19) | 60-39 | |
| » Starters: Ed Klepfer vs Rube Foster | Second | 3½ out |
| Tuesday, August 7 |
| » Defeated Indians (56-50), 8-6 | Fenway Park (32-19) | 61-39 | |
| » Starters: Joe Boehling vs Ernie Shore | Second | 2½ out |
| Wednesday, August 8 |
| » Lost to Tigers (55-49), 6-2 | Fenway Park (32-20) | 61-40 | |
| » Starters: Hooks Dauss vs Dutch Leonard | Second | 2½ out |
| Friday, August 10 |
| » Defeated Tigers (55-50), 5-4 | Fenway Park (33-20) | 62-40 | |
| » Starters: Bill James vs Babe Ruth | Second | 2½ out |
| » Defeated Tigers (55-51), 5-1 | Fenway Park (34-20) | 63-40 | Won 2 |
| » Starters: Howard Ehmke vs Rube Foster | Second | 2½ out |
| Saturday, August 11 |
| » Defeated Tigers (55-52), 7-2 | Fenway Park (35-20) | 64-40 | Won 3 |
| » Starters: Hooks Dauss vs Carl Mays | Second | 2 out |
| » Lost to Tigers (56-52), 5-0 | Fenway Park (35-21) | 64-41 | |
| » Starters: Howard Ehmke vs Ernie Shore | Second | 2 out |
| Monday, August 13 |
| » Defeated Athletics (40-64), 5-1 | Shibe Park (4-1) | 65-41 | |
| » Starters: Dutch Leonard vs Elmer Myers | Second | 2 out |
| Tuesday, August 14 |
| » Lost to Athletics (41-64), 3-1 | Shibe Park (4-2) | 65-42 | |
| » Starters: Babe Ruth vs Bullet Joe Bush | Second | 2½ out |
| Wednesday, August 15 |
| » Defeated Athletics (41-65), 4-2 | Shibe Park (5-2) | 66-42 | |
| » Starters: Rube Foster vs Win Noyes | Second | 2½ out |
| Friday, August 17 |
| » Defeated Indians (61-55), 3-1 | League Park II (3-5) | 67-42 | Won 2 |
| » Starters: Carl Mays vs Jim Bagby | First | -- |
| Saturday, August 18 |
| » Lost to Indians (62-55), 2-1 | League Park II (3-6) | 67-43 | |
| » Starters: Dutch Leonard vs Stan Coveleski | Second | 2 out |
| » Defeated Indians (62-56), 9-1 | League Park II (4-6) | 68-43 | |
| » Starters: Babe Ruth vs Guy Morton | Second | 2 out |
| Sunday, August 19 |
| » Lost to Indians (63-56), 7-2 | League Park II (4-7) | 68-44 | |
| » Starters: Sad Sam Jones vs Ed Klepfer | Second | 2 out |
| Monday, August 20 |
| » Lost to White Sox (73-44), 7-0 | Comiskey Park I (2-6) | 68-45 | Lost 2 |
| » Starters: Rube Foster vs Red Faber | Second | 2 out |
| » Defeated White Sox (73-45), 3-1 | Comiskey Park I (3-6) | 69-45 | |
| » Starters: Carl Mays vs Eddie Cicotte | Second | 2 out |
| Tuesday, August 21 |
| » Lost to White Sox (74-45), 2-0 | Comiskey Park I (3-7) | 69-46 | |
| » Starters: Babe Ruth vs Reb Russell | Second | 3 out |
| Wednesday, August 22 |
| » Defeated White Sox (74-46), 5-1 | Comiskey Park I (4-7) | 70-46 | |
| » Starters: Dutch Leonard vs Lefty Williams | Second | 2 out |
| Thursday, August 23 |
| » Defeated Browns (46-74), 4-2 | Sportsman's Park III (8-2) | 71-46 | Won 2 |
| » Starters: Carl Mays vs Allen Sothoron | Second | 2 out |
| Saturday, August 25 |
| » Defeated Browns (46-75), 3-2 | Sportsman's Park III (9-2) | 72-46 | Won 3 |
| » Starters: Rube Foster vs Ernie Koob | Second | 2 out |
| Sunday, August 26 |
| » Defeated Tigers (62-59), 6-3 | Tiger Stadium (6-3) | 73-46 | Won 4 |
| » Starters: Dutch Leonard vs Howard Ehmke | Second | 2 out |
| Monday, August 27 |
| » Lost to Tigers (63-59), 5-1 | Tiger Stadium (6-4) | 73-47 | |
| » Starters: Babe Ruth vs Bill James | Second | 3 out |
| Thursday, August 30 |
| » Tied Athletics, 1-1 | Fenway Park (35-21) | 73-47 | |
| » Starters: Jing Johnson vs Dutch Leonard | Second | 5 out |
| Friday, August 31 |
| » Defeated Athletics (44-76), 5-3 | Fenway Park (36-21) | 74-47 | |
| » Starters: Socks Seibold vs Babe Ruth | Second | 4½ out |
| » Defeated Athletics (44-77), 6-2 | Fenway Park (37-21) | 75-47 | Won 2 |
| » Starters: Elmer Myers vs Carl Mays | Second | 4½ out |
| Saturday, September 1 |
| » Defeated Athletics (44-78), 6-1 | Fenway Park (38-21) | 76-47 | Won 3 |
| » Starters: Rube Schauer vs Ernie Shore | Second | 3½ out |
| Monday, September 3 |
| » Lost to Yankees (57-65), 1-0 | Fenway Park (38-22) | 76-48 | |
| » Starters: Bob Shawkey vs Rube Foster | Second | 6½ out |
| » Lost to Yankees (58-65), 4-1 | Fenway Park (38-23) | 76-49 | Lost 2 |
| » Starters: Ray Fisher vs Dutch Leonard | Second | 6½ out |
| Tuesday, September 4 |
| » Defeated Yankees (58-66), 4-2 | Fenway Park (39-23) | 77-49 | |
| » Starters: George Mogridge vs Babe Ruth | Second | 7 out |
| » Lost to Yankees (59-66), 7-3 | Fenway Park (39-24) | 77-50 | |
| » Starters: Ray Caldwell vs Carl Mays | Second | 7 out |
| Wednesday, September 5 |
| » Defeated Athletics (47-79), 2-1 | Shibe Park (6-2) | 78-50 | |
| » Starters: Dutch Leonard vs Socks Seibold | Second | 7 out |
| Thursday, September 6 |
| » Defeated Athletics (47-80), 3-1 | Shibe Park (7-2) | 79-50 | Won 2 |
| » Starters: Ernie Shore vs Rube Schauer | Second | 6½ out |
| Friday, September 7 |
| » Defeated Athletics (47-81), 5-0 | Shibe Park (8-2) | 80-50 | Won 3 |
| » Starters: Rube Foster vs Jing Johnson | Second | 6 out |
| Future Red Sox Roy Partee is born in Los Angeles, CA. |
| Monday, September 10 |
| » Lost to Senators (61-68), 2-1 | Griffith Stadium (6-2) | 80-51 | |
| » Starters: Babe Ruth vs Harry Harper | Second | 6½ out |
| » Defeated Senators (61-69), 4-3 | Griffith Stadium (7-2) | 81-51 | |
| » Starters: Carl Mays vs Jim Shaw | Second | 6½ out |
| Tuesday, September 11 |
| » Lost to Senators (62-69), 4-3 | Griffith Stadium (7-3) | 81-52 | |
| » Starters: Dutch Leonard vs Walter Johnson | Second | 7 out |
| Wednesday, September 12 |
| » Tied Senators, 1-1 | Griffith Stadium (7-3) | 81-52 | |
| » Starters: Ernie Shore vs Doc Ayers | Second | 7 out |
| Thursday, September 13 |
| » Lost to Yankees (66-70), 13-7 | Polo Grounds V (4-4) | 81-53 | Lost 2 |
| » Starters: Rube Foster vs Bob Shawkey | Second | 7½ out |
| Friday, September 14 |
| » Defeated Yankees (66-71), 6-5 | Polo Grounds V (5-4) | 82-53 | |
| » Starters: Carl Mays vs George Mogridge | Second | 7½ out |
| Saturday, September 15 |
| » Defeated Yankees (66-72), 8-3 | Polo Grounds V (6-4) | 83-53 | Won 2 |
| » Starters: Babe Ruth vs Nick Cullop | Second | 7 out |
| Monday, September 17 |
| » Defeated Yankees (66-73), 6-1 | Polo Grounds V (7-4) | 84-53 | Won 3 |
| » Starters: Dutch Leonard vs Ray Fisher | Second | 7 out |
| Wednesday, September 19 |
| » Lost to Tigers (70-72), 5-2 | Fenway Park (39-25) | 84-54 | |
| » Starters: Bill James vs Ernie Shore | Second | 8 out |
| » Lost to Tigers (71-72), 1-0 | Fenway Park (39-26) | 84-55 | Lost 2 |
| » Starters: Hooks Dauss vs Carl Mays | Second | 8 out |
| Thursday, September 20 |
| » Lost to Tigers (72-72), 1-0 | Fenway Park (39-27) | 84-56 | Lost 3 |
| » Starters: Willie Mitchell vs Babe Ruth | Second | 9 out |
| Friday, September 21 |
| » Lost to White Sox (96-49), 2-1 | Fenway Park (39-28) | 84-57 | Lost 4 |
| » Starters: Red Faber vs Dutch Leonard | Second | 10 out |
| Saturday, September 22 |
| » Defeated White Sox (96-50), 4-1 | Fenway Park (40-28) | 85-57 | |
| » Starters: Joe Benz vs Carl Mays | Second | 9 out |
| » Major-league debuts: Jimmy Cooney (Red Sox) |
| Monday, September 24 |
| » Defeated White Sox (96-51), 3-0 | Fenway Park (41-28) | 86-57 | Won 2 |
| » Starters: Reb Russell vs Babe Ruth | Second | 8 out |
| Tuesday, September 25 |
| » Defeated Indians (85-63), 4-3 | Fenway Park (42-28) | 87-57 | Won 3 |
| » Starters: Ed Klepfer vs Ernie Shore | Second | 8 out |
| Wednesday, September 26 |
| » Lost to Indians (86-63), 2-0 | Fenway Park (42-29) | 87-58 | |
| » Starters: Fritz Coumbe vs Dutch Leonard | Second | 8 out |
| Friday, September 28 |
| » Lost to Browns (57-95), 2-1 | Fenway Park (42-30) | 87-59 | Lost 2 |
| » Starters: Allen Sothoron vs Carl Mays | Second | 9 out |
| Saturday, September 29 |
| » Defeated Browns (57-96), 13-5 | Fenway Park (43-30) | 88-59 | |
| » Starters: Ernie Koob vs Rube Foster | Second | 8 out |
| » Defeated Browns (57-97), 11-0 | Fenway Park (44-30) | 89-59 | Won 2 |
| » Starters: Dave Davenport vs Babe Ruth | Second | 8 out |
| Tuesday, October 2 |
| » Lost to Senators (72-78), 9-7 | Fenway Park (44-31) | 89-60 | |
| » Starters: Harry Harper vs Dutch Leonard | Second | 7½ out |
| » Defeated Senators (72-79), 2-1 | Fenway Park (45-31) | 90-60 | |
| » Starters: Doc Ayers vs Carl Mays | Second | 7½ out |
| Wednesday, October 3 |
| » Lost to Senators (73-79), 6-0 | Fenway Park (45-32) | 90-61 | |
| » Starters: Walter Johnson vs Babe Ruth | Second | 8 out |
| Thursday, October 4 |
| » Lost to Senators (74-79), 5-4 | Fenway Park (45-33) | 90-62 | Lost 2 |
| » Starters: Jim Shaw vs Herb Pennock | Second | 8½ out |
| Wednesday, October 17 |
| Future Red Sox John Ostrowski is born in Chicago, IL. |
Game information provided by Retrosheet (www.retrosheet.org) |
