| Friday, January 28 |
| Future Indian Bob Muncrief is born in Madill, OK. |
| Thursday, March 2 |
| Future Indian Mickey Rocco is born in St. Paul, MN. |
| Tuesday, April 11 |
| Future Indian Sam Chapman is born in Tiburon, CA. |
| Wednesday, April 12 |
| » Lost to Browns (1-0), 6-1 | League Park II (0-1) | 0-1 | |
| » Starters: Bob Groom vs Willie Mitchell | Second | 1 out |
| Thursday, April 13 |
| » Lost to Browns (2-0), 4-2 | League Park II (0-2) | 0-2 | Lost 2 |
| » Starters: Dave Davenport vs Guy Morton | Fifth | 2 out |
| Friday, April 14 |
| » Major-league debuts: George Cunningham (Tigers) |
| Saturday, April 15 |
| » Defeated Browns (2-1), 3-0 | League Park II (1-2) | 1-2 | |
| » Starters: Jim Park vs Ed Klepfer | Fifth | 2 out |
| Sunday, April 16 |
| » Defeated Tigers (1-4), 4-3 | League Park II (2-2) | 2-2 | Won 2 |
| » Starters: Hooks Dauss vs Jim Bagby | Fifth | 1½ out |
| Monday, April 17 |
| » Lost to Tigers (2-4), 3-1 | League Park II (2-3) | 2-3 | |
| » Starters: George Cunningham vs Stan Coveleski | Fifth | 2½ out |
| Tuesday, April 18 |
| » Lost to Tigers (3-4), 4-3 | League Park II (2-4) | 2-4 | Lost 2 |
| » Starters: Harry Coveleski vs Guy Morton | Seventh | 2½ out |
| Friday, April 21 |
| » Lost to Browns (5-3), 11-1 | Sportsman's Park III (0-1) | 2-5 | Lost 3 |
| » Starters: Willie Mitchell vs Bob Groom | Seventh | 3 out |
| Saturday, April 22 |
| » Tied Browns, 1-1 | Sportsman's Park III (0-1) | 2-5 | |
| » Starters: Ed Klepfer vs Dave Davenport | Seventh | 3 out |
| Sunday, April 23 |
| » Defeated Browns (5-4), 14-2 | Sportsman's Park III (1-1) | 3-5 | |
| » Starters: Guy Morton vs Bill Fincher | Seventh | 2½ out |
| Monday, April 24 |
| » Defeated Browns (5-5), 5-4 | Sportsman's Park III (2-1) | 4-5 | Won 2 |
| » Starters: Grover Lowdermilk vs Bob Groom | Sixth | 2 out |
| Tuesday, April 25 |
| » Defeated White Sox (6-7), 9-2 | League Park II (3-4) | 5-5 | Won 3 |
| » Starters: Eddie Cicotte vs Fritz Coumbe | Fourth | 2 out |
| Wednesday, April 26 |
| » Defeated White Sox (6-8), 5-3 | League Park II (4-4) | 6-5 | Won 4 |
| » Starters: Jim Scott vs Stan Coveleski | Third | 1 out |
| Thursday, April 27 |
| » Lost to White Sox (7-8), 5-3 | League Park II (4-5) | 6-6 | |
| » Starters: Red Faber vs Willie Mitchell | Fourth | 1½ out |
| Friday, April 28 |
| » Defeated White Sox (7-9), 2-1 | League Park II (5-5) | 7-6 | |
| » Starters: Lefty Williams vs Guy Morton | Fourth | 1½ out |
| Saturday, April 29 |
| » Lost to Tigers (9-5), 5-4 | Tiger Stadium (0-1) | 7-7 | |
| » Starters: Ed Klepfer vs Jean Dubuc | Fifth | 2 out |
| Sunday, April 30 |
| » Defeated Tigers (9-6), 12-6 | Tiger Stadium (1-1) | 8-7 | |
| » Starters: Jim Bagby vs Bill James | Fourth | 1 out |
| Monday, May 1 |
| » Defeated Tigers (9-7), 2-0 | Tiger Stadium (2-1) | 9-7 | Won 2 |
| » Starters: Stan Coveleski vs Hooks Dauss | Second | ½ out |
| Tuesday, May 2 |
| » Defeated Tigers (9-8), 6-1 | Tiger Stadium (3-1) | 10-7 | Won 3 |
| » Starters: Guy Morton vs Harry Coveleski | Second | ½ out |
| Thursday, May 4 |
| » Defeated White Sox (10-10), 2-0 | Comiskey Park I (1-0) | 11-7 | Won 4 |
| » Starters: Fritz Coumbe vs Lefty Williams | Second | ½ out |
| Friday, May 5 |
| » Defeated White Sox (10-11), 3-2 | Comiskey Park I (2-0) | 12-7 | Won 5 |
| » Starters: Stan Coveleski vs Reb Russell | Second | 1 out |
| Saturday, May 6 |
| » Defeated White Sox (10-12), 4-1 | Comiskey Park I (3-0) | 13-7 | Won 6 |
| » Starters: Guy Morton vs Jim Scott | First | -- |
| Sunday, May 7 |
| » Defeated White Sox (10-13), 5-2 | Comiskey Park I (4-0) | 14-7 | Won 7 |
| » Starters: Fritz Coumbe vs Red Faber | First | -- |
| Monday, May 8 |
| » Defeated Tigers (10-11), 3-1 | League Park II (6-5) | 15-7 | Won 8 |
| » Starters: Jean Dubuc vs Jim Bagby | First | -- |
| Tuesday, May 9 |
| » Lost to Red Sox (11-11), 5-1 | Fenway Park (0-1) | 15-8 | |
| » Starters: Stan Coveleski vs Dutch Leonard | First | -- |
| Wednesday, May 10 |
| » Defeated Red Sox (11-12), 6-2 | Fenway Park (1-1) | 16-8 | |
| » Starters: Guy Morton vs Babe Ruth | First | -- |
| Thursday, May 11 |
| » Lost to Red Sox (12-12), 6-5 | Fenway Park (1-2) | 16-9 | |
| » Starters: Willie Mitchell vs Ernie Shore | First | -- |
| Friday, May 12 |
| » Defeated Red Sox (12-13), 3-1 | Fenway Park (2-2) | 17-9 | |
| » Starters: Fritz Coumbe vs Herb Pennock | First | -- |
| Saturday, May 13 |
| » Defeated Yankees (13-11), 4-2 | Polo Grounds V (1-0) | 18-9 | Won 2 |
| » Starters: Stan Coveleski vs Ray Fisher | First | -- |
| Monday, May 15 |
| » Defeated Yankees (13-12), 6-4 | Polo Grounds V (2-0) | 19-9 | Won 3 |
| » Starters: Guy Morton vs Cliff Markle | First | -- |
| Tuesday, May 16 |
| » Major-league debuts: Patsy Gharrity (Senators) |
| Thursday, May 18 |
| » Defeated Senators (18-10), 4-2 | Griffith Stadium (1-0) | 20-9 | Won 4 |
| » Starters: Stan Coveleski vs Walter Johnson | First | -- |
| Friday, May 19 |
| » Defeated Senators (18-11), 7-1 | Griffith Stadium (2-0) | 21-9 | Won 5 |
| » Starters: Guy Morton vs Joe Boehling | First | -- |
| Saturday, May 20 |
| » Lost to Senators (19-11), 13-3 | Griffith Stadium (2-1) | 21-10 | |
| » Starters: Ed Klepfer vs Bert Gallia | First | -- |
| Sunday, May 21 |
| » Lost to Senators (20-11), 4-3 | League Park II (6-6) | 21-11 | Lost 2 |
| » Starters: Walter Johnson vs Stan Coveleski | First | -- |
| Monday, May 22 |
| » Lost to Athletics (13-17), 10-8 | Shibe Park (0-1) | 21-12 | Lost 3 |
| » Starters: Fritz Coumbe vs Elmer Myers | Second | ½ out |
| Wednesday, May 24 |
| » Defeated Athletics (13-18), 5-4 | Shibe Park (1-1) | 22-12 | |
| » Starters: Guy Morton vs Bullet Joe Bush | First | -- |
| Friday, May 26 |
| » Defeated Browns (12-20), 4-2 | League Park II (7-6) | 23-12 | Won 2 |
| » Starters: Dave Davenport vs Ed Klepfer | First | -- |
| Sunday, May 28 |
| » Lost to White Sox (15-19), 2-0 | Comiskey Park I (4-1) | 23-13 | |
| » Starters: Fritz Coumbe vs Jim Scott | Second | 1½ out |
| » Lost to White Sox (16-19), 2-0 | Comiskey Park I (4-2) | 23-14 | Lost 2 |
| » Starters: Guy Morton vs Red Faber | Second | 1½ out |
| Tuesday, May 30 |
| » Lost to Browns (14-23), 5-4 | Sportsman's Park III (2-2) | 23-15 | Lost 3 |
| » Starters: Stan Coveleski vs Dave Davenport | Second | 1 out |
| » Tied Browns, 1-1 | Sportsman's Park III (2-2) | 23-15 | |
| » Starters: Jim Bagby vs George Baumgardner | Second | 1 out |
| Wednesday, May 31 |
| » Defeated Browns (14-24), 10-5 | Sportsman's Park III (3-2) | 24-15 | |
| » Starters: Willie Mitchell vs Bob Groom | First | -- |
| Thursday, June 1 |
| » Defeated Browns (14-25), 3-2 | Sportsman's Park III (4-2) | 25-15 | Won 2 |
| » Starters: Guy Morton vs Jim Park | First | -- |
| » Lost to Browns (15-25), 6-5 | Sportsman's Park III (4-3) | 25-16 | |
| » Starters: Grover Lowdermilk vs George Baumgardner | First | -- |
| Friday, June 2 |
| » Lost to Browns (16-25), 2-1 | Sportsman's Park III (4-4) | 25-17 | Lost 2 |
| » Starters: Ed Klepfer vs Carl Weilman | Second | 1 out |
| Saturday, June 3 |
| » Defeated Red Sox (22-19), 11-2 | League Park II (8-6) | 26-17 | |
| » Starters: Dutch Leonard vs Stan Coveleski | First | -- |
| Sunday, June 4 |
| » Defeated Red Sox (22-20), 9-3 | League Park II (9-6) | 27-17 | Won 2 |
| » Starters: Carl Mays vs Jim Bagby | First | -- |
| Monday, June 5 |
| » Lost to Red Sox (23-20), 5-0 | League Park II (9-7) | 27-18 | |
| » Starters: Babe Ruth vs Fritz Coumbe | First | -- |
| Thursday, June 8 |
| » Tied Senators, 5-5 | League Park II (9-7) | 27-18 | |
| » Starters: Harry Harper vs Stan Coveleski | First | -- |
| Friday, June 9 |
| » Lost to Senators (25-19), 7-4 | League Park II (9-8) | 27-19 | Lost 2 |
| » Starters: Walter Johnson vs Willie Mitchell | First | -- |
| Saturday, June 10 |
| » Defeated Athletics (15-27), 10-1 | League Park II (10-8) | 28-19 | |
| » Starters: Tom Sheehan vs Stan Coveleski | First | -- |
| Sunday, June 11 |
| » Defeated Athletics (15-28), 7-2 | League Park II (11-8) | 29-19 | Won 2 |
| » Starters: Elmer Myers vs Guy Morton | First | -- |
| Monday, June 12 |
| » Defeated Athletics (15-29), 3-1 | League Park II (12-8) | 30-19 | Won 3 |
| » Starters: Bullet Joe Bush vs Ed Klepfer | First | -- |
| Tuesday, June 13 |
| » Defeated Athletics (15-30), 11-2 | League Park II (13-8) | 31-19 | Won 4 |
| » Starters: Elmer Myers vs Jim Bagby | First | -- |
| Thursday, June 15 |
| » Defeated Yankees (25-23), 3-2 | League Park II (14-8) | 32-19 | Won 5 |
| » Starters: Ray Caldwell vs Stan Coveleski | First | -- |
| Saturday, June 17 |
| » Lost to Yankees (26-23), 5-3 | League Park II (14-9) | 32-20 | |
| » Starters: Bob Shawkey vs Jim Bagby | First | -- |
| Sunday, June 18 |
| » Lost to Yankees (27-23), 19-3 | League Park II (14-10) | 32-21 | Lost 2 |
| » Starters: Nick Cullop vs Fritz Coumbe | First | -- |
| Monday, June 19 |
| » Lost to Yankees (28-23), 7-6 | League Park II (14-11) | 32-22 | Lost 3 |
| » Starters: Ray Caldwell vs Stan Coveleski | First | -- |
| Tuesday, June 20 |
| » Lost to Tigers (31-24), 2-1 | Tiger Stadium (3-2) | 32-23 | Lost 4 |
| » Starters: Grover Lowdermilk vs Hooks Dauss | First | -- |
| Wednesday, June 21 |
| » Lost to Tigers (32-24), 3-0 | Tiger Stadium (3-3) | 32-24 | Lost 5 |
| » Starters: Jim Bagby vs Harry Coveleski | First | -- |
| Thursday, June 22 |
| » Defeated Tigers (32-25), 4-3 | Tiger Stadium (4-3) | 33-24 | |
| » Starters: Stan Coveleski vs Jean Dubuc | First | -- |
| Saturday, June 24 |
| » Defeated Tigers (32-26), 10-8 | Tiger Stadium (5-3) | 34-24 | Won 2 |
| » Starters: Grover Lowdermilk vs Hooks Dauss | First | -- |
| Sunday, June 25 |
| » Lost to White Sox (29-28), 4-3 | Comiskey Park I (4-3) | 34-25 | |
| » Starters: Fritz Coumbe vs Jim Scott | First | -- |
| Monday, June 26 |
| » Defeated White Sox (29-29), 2-0 | League Park II (15-11) | 35-25 | |
| » Starters: Dave Danforth vs Fred Beebe | First | -- |
| Tuesday, June 27 |
| » Lost to White Sox (30-29), 4-2 | League Park II (15-12) | 35-26 | |
| » Starters: Lefty Williams vs Jim Bagby | First | -- |
| Wednesday, June 28 |
| » Lost to White Sox (31-29), 5-1 | League Park II (15-13) | 35-27 | Lost 2 |
| » Starters: Reb Russell vs Stan Coveleski | Second | ½ out |
| Thursday, June 29 |
| » Lost to Browns (29-35), 7-0 | League Park II (15-14) | 35-28 | Lost 3 |
| » Starters: Dave Davenport vs Grover Lowdermilk | Second | 1½ out |
| Friday, June 30 |
| » Defeated Browns (29-36), 2-1 | League Park II (16-14) | 36-28 | |
| » Starters: Bob Groom vs Fred Beebe | Second | 1½ out |
| Saturday, July 1 |
| » Defeated Browns (29-37), 5-4 | League Park II (17-14) | 37-28 | Won 2 |
| » Starters: Earl Hamilton vs Jim Bagby | Second | 1½ out |
| Sunday, July 2 |
| » Defeated Browns (29-38), 3-2 | League Park II (18-14) | 38-28 | Won 3 |
| » Starters: Dave Davenport vs Ed Klepfer | Second | 1 out |
| Monday, July 3 |
| » Defeated Tigers (34-35), 6-4 | League Park II (19-14) | 39-28 | Won 4 |
| » Starters: Hooks Dauss vs Grover Lowdermilk | Second | 1 out |
| Tuesday, July 4 |
| » Lost to Tigers (35-35), 6-2 | League Park II (19-15) | 39-29 | |
| » Starters: Bernie Boland vs Fred Beebe | Second | 1 out |
| » Defeated Tigers (35-36), 6-3 | League Park II (20-15) | 40-29 | |
| » Starters: Bill James vs Stan Coveleski | Second | 1 out |
| Thursday, July 6 |
| » Lost to Red Sox (38-31), 6-5 | Fenway Park (2-3) | 40-30 | |
| » Starters: Ed Klepfer vs Rube Foster | Second | 2½ out |
| Friday, July 7 |
| » Lost to Red Sox (39-31), 2-1 | Fenway Park (2-4) | 40-31 | Lost 2 |
| » Starters: Fred Beebe vs Babe Ruth | Second | 3½ out |
| Saturday, July 8 |
| » Defeated Red Sox (39-32), 5-1 | Fenway Park (3-4) | 41-31 | |
| » Starters: Stan Coveleski vs Ernie Shore | Second | 2½ out |
| Monday, July 10 |
| » Defeated Yankees (43-29), 3-2 | Polo Grounds V (3-0) | 42-31 | Won 2 |
| » Starters: Ed Klepfer vs Bob Shawkey | Second | 1½ out |
| Tuesday, July 11 |
| » Lost to Yankees (44-29), 8-2 | Polo Grounds V (3-1) | 42-32 | |
| » Starters: Fred Beebe vs Nick Cullop | Second | 1½ out |
| » Defeated Yankees (44-30), 4-2 | Polo Grounds V (4-1) | 43-32 | |
| » Starters: Grover Lowdermilk vs Ray Keating | Second | 1½ out |
| Wednesday, July 12 |
| » Defeated Yankees (44-31), 1-0 | Polo Grounds V (5-1) | 44-32 | Won 2 |
| » Starters: Jim Bagby vs Ray Caldwell | First | -- |
| » Defeated Yankees (44-32), 6-3 | Polo Grounds V (6-1) | 45-32 | Won 3 |
| » Starters: Al Gould vs Ray Fisher | First | -- |
| Thursday, July 13 |
| » Lost to Yankees (45-32), 6-3 | Polo Grounds V (6-2) | 45-33 | |
| » Starters: Ed Klepfer vs Bob Shawkey | Second | ½ out |
| Friday, July 14 |
| » Lost to Senators (40-37), 4-3 | Griffith Stadium (2-2) | 45-34 | Lost 2 |
| » Starters: Fred Beebe vs Doc Ayers | Second | 1 out |
| Saturday, July 15 |
| » Lost to Senators (41-37), 3-2 | Griffith Stadium (2-3) | 45-35 | Lost 3 |
| » Starters: Jim Bagby vs Walter Johnson | Second | 1 out |
| Sunday, July 16 |
| » Lost to Senators (42-37), 4-2 | League Park II (20-16) | 45-36 | Lost 4 |
| » Starters: Joe Boehling vs Stan Coveleski | Third | 1½ out |
| Monday, July 17 |
| » Defeated Senators (42-38), 7-5 | Griffith Stadium (3-3) | 46-36 | |
| » Starters: Ed Klepfer vs Harry Harper | Third | 2 out |
| Tuesday, July 18 |
| » Lost to Senators (43-38), 3-2 | Griffith Stadium (3-4) | 46-37 | |
| » Starters: Al Gould vs Bert Gallia | Third | 2 out |
| Wednesday, July 19 |
| » Defeated Athletics (18-59), 12-5 | Shibe Park (2-1) | 47-37 | |
| » Starters: Jim Bagby vs George Hesselbacher | Third | 2½ out |
| Thursday, July 20 |
| » Defeated Athletics (18-60), 4-2 | Shibe Park (3-1) | 48-37 | Won 2 |
| » Starters: Fred Beebe vs Tom Sheehan | Third | 2 out |
| » Lost to Athletics (19-60), 2-0 | Shibe Park (3-2) | 48-38 | |
| » Starters: Grover Lowdermilk vs Bullet Joe Bush | Third | 2 out |
| Future Indian Don Black is born in Salix, IA. |
| Friday, July 21 |
| » Defeated Athletics (19-61), 7-2 | Shibe Park (4-2) | 49-38 | |
| » Starters: Fritz Coumbe vs Jack Nabors | Third | 1½ out |
| Sunday, July 23 |
| » Lost to Browns (38-49), 5-2 | League Park II (20-17) | 49-39 | |
| » Starters: Bob Groom vs Al Gould | Third | 2½ out |
| Tuesday, July 25 |
| » Defeated Red Sox (49-38), 5-4 | League Park II (21-17) | 50-39 | |
| » Starters: Babe Ruth vs Jim Bagby | Third | 1½ out |
| Wednesday, July 26 |
| » Lost to Red Sox (50-38), 3-2 | League Park II (21-18) | 50-40 | |
| » Starters: Carl Mays vs Fred Beebe | Third | 1½ out |
| Thursday, July 27 |
| » Lost to Red Sox (51-38), 7-6 | League Park II (21-19) | 50-41 | Lost 2 |
| » Starters: Rube Foster vs Stan Coveleski | Third | 2½ out |
| Friday, July 28 |
| » Lost to Red Sox (52-38), 3-2 | League Park II (21-20) | 50-42 | Lost 3 |
| » Starters: Ernie Shore vs Al Gould | Third | 3½ out |
| Saturday, July 29 |
| » Defeated Senators (47-45), 10-0 | League Park II (22-20) | 51-42 | |
| » Starters: Bert Gallia vs Jim Bagby | Fourth | 2 out |
| Sunday, July 30 |
| » Lost to Senators (48-45), 2-1 | League Park II (22-21) | 51-43 | |
| » Starters: Walter Johnson vs Fred Beebe | Fourth | 2½ out |
| Monday, July 31 |
| » Lost to Senators (49-45), 11-1 | League Park II (22-22) | 51-44 | Lost 2 |
| » Starters: Harry Harper vs Grover Lowdermilk | Fourth | 3½ out |
| Tuesday, August 1 |
| » Defeated Senators (49-46), 6-1 | League Park II (23-22) | 52-44 | |
| » Starters: Joe Boehling vs Stan Coveleski | Fourth | 3½ out |
| Wednesday, August 2 |
| » Defeated Senators (49-47), 3-0 | League Park II (24-22) | 53-44 | Won 2 |
| » Starters: Bert Gallia vs Al Gould | Third | 3½ out |
| Thursday, August 3 |
| » Defeated Athletics (19-75), 3-1 | League Park II (25-22) | 54-44 | Won 3 |
| » Starters: Bullet Joe Bush vs Jim Bagby | Third | 3 out |
| Friday, August 4 |
| » Defeated Athletics (19-76), 5-2 | League Park II (26-22) | 55-44 | Won 4 |
| » Starters: Tom Sheehan vs Fred Beebe | Third | 2½ out |
| Saturday, August 5 |
| » Defeated Athletics (19-77), 12-3 | League Park II (27-22) | 56-44 | Won 5 |
| » Starters: Jing Johnson vs Stan Coveleski | Third | 2½ out |
| Sunday, August 6 |
| » Defeated Athletics (19-78), 5-2 | League Park II (28-22) | 57-44 | Won 6 |
| » Starters: Jack Nabors vs Guy Morton | Third | 1½ out |
| Monday, August 7 |
| » Lost to Yankees (55-47), 3-2 | League Park II (28-23) | 57-45 | |
| » Starters: Ray Fisher vs Jim Bagby | Third | 2½ out |
| Tuesday, August 8 |
| » Defeated Yankees (55-48), 9-4 | League Park II (29-23) | 58-45 | |
| » Starters: Allen Russell vs Al Gould | Third | 1½ out |
| Wednesday, August 9 |
| » Defeated Yankees (55-49), 5-3 | League Park II (30-23) | 59-45 | Won 2 |
| » Starters: Bob Shawkey vs Stan Coveleski | Third | 1 out |
| Thursday, August 10 |
| » Defeated Yankees (55-50), 3-2 | League Park II (31-23) | 60-45 | Won 3 |
| » Starters: Allen Russell vs Otis Lambeth | Second | 1 out |
| Friday, August 11 |
| » Lost to Browns (58-51), 5-4 | Sportsman's Park III (4-5) | 60-46 | |
| » Starters: Jim Bagby vs Dave Davenport | Second | 2 out |
| » Lost to Browns (59-51), 3-1 | Sportsman's Park III (4-6) | 60-47 | Lost 2 |
| » Starters: Ed Klepfer vs Bob Groom | Second | 2 out |
| Saturday, August 12 |
| » Lost to Browns (60-51), 11-0 | Sportsman's Park III (4-7) | 60-48 | Lost 3 |
| » Starters: Guy Morton vs Eddie Plank | Third | 3 out |
| Sunday, August 13 |
| » Defeated Browns (60-52), 4-3 | League Park II (32-23) | 61-48 | |
| » Starters: Carl Weilman vs Otis Lambeth | Second | 2½ out |
| Monday, August 14 |
| » Defeated Tigers (60-53), 3-2 | League Park II (33-23) | 62-48 | Won 2 |
| » Starters: Jean Dubuc vs Jim Bagby | Second | 1½ out |
| Wednesday, August 16 |
| » Lost to Yankees (58-52), 5-3 | Polo Grounds V (6-3) | 62-49 | |
| » Starters: Al Gould vs Allen Russell | Second | 3½ out |
| Thursday, August 17 |
| » Lost to Yankees (59-52), 5-4 | Polo Grounds V (6-4) | 62-50 | Lost 2 |
| » Starters: Stan Coveleski vs Ray Fisher | Second | 3½ out |
| Friday, August 18 |
| » Lost to Yankees (60-52), 4-3 | Polo Grounds V (6-5) | 62-51 | Lost 3 |
| » Starters: Otis Lambeth vs Urban Shocker | Third | 3½ out |
| Saturday, August 19 |
| » Lost to Red Sox (66-47), 2-1 | Fenway Park (3-5) | 62-52 | Lost 4 |
| » Starters: Joe Boehling vs Babe Ruth | Third | 4½ out |
| Monday, August 21 |
| » Lost to Red Sox (67-47), 4-0 | Fenway Park (3-6) | 62-53 | Lost 5 |
| » Starters: Guy Morton vs Ernie Shore | Fourth | 5½ out |
| Tuesday, August 22 |
| » Lost to Red Sox (68-47), 3-0 | Fenway Park (3-7) | 62-54 | Lost 6 |
| » Starters: Jim Bagby vs Carl Mays | Sixth | 6½ out |
| Wednesday, August 23 |
| » Lost to Red Sox (69-47), 7-3 | Fenway Park (3-8) | 62-55 | Lost 7 |
| » Starters: Joe Boehling vs Dutch Leonard | Sixth | 7½ out |
| Thursday, August 24 |
| » Lost to Athletics (25-88), 6-5 | Shibe Park (4-3) | 62-56 | Lost 8 |
| » Starters: Otis Lambeth vs Jack Nabors | Fifth | 8 out |
| » Defeated Athletics (25-89), 4-2 | Shibe Park (5-3) | 63-56 | |
| » Starters: Al Gould vs Jing Johnson | Fifth | 8 out |
| Future Indian Chubby Dean is born in Mount Airy, NC. |
| Friday, August 25 |
| » Defeated Athletics (25-90), 13-9 | Shibe Park (6-3) | 64-56 | Won 2 |
| » Starters: Jim Bagby vs Jack Nabors | Fourth | 6½ out |
| » Defeated Athletics (25-91), 10-2 | Shibe Park (7-3) | 65-56 | Won 3 |
| » Starters: Fred Beebe vs Bullet Joe Bush | Fourth | 6½ out |
| Saturday, August 26 |
| » Lost to Athletics (26-91), 5-0 | Shibe Park (7-4) | 65-57 | |
| » Starters: Stan Coveleski vs Bullet Joe Bush | Sixth | 6½ out |
| Sunday, August 27 |
| » Defeated Yankees (65-56), 5-1 | League Park II (34-23) | 66-57 | |
| » Starters: Allen Russell vs Otis Lambeth | Fourth | 6 out |
| Monday, August 28 |
| » Lost to Senators (58-61), 2-0 | Griffith Stadium (3-5) | 66-58 | |
| » Starters: Joe Boehling vs Walter Johnson | Fifth | 6½ out |
| Tuesday, August 29 |
| » Defeated Senators (58-62), 4-0 | Griffith Stadium (4-5) | 67-58 | |
| » Starters: Jim Bagby vs Jim Shaw | Fifth | 5 out |
| Wednesday, August 30 |
| » Lost to Senators (59-62), 3-1 | Griffith Stadium (4-6) | 67-59 | |
| » Starters: Fritz Coumbe vs Bert Gallia | Fifth | 6 out |
| Thursday, August 31 |
| » Lost to Senators (60-62), 5-3 | Griffith Stadium (4-7) | 67-60 | Lost 2 |
| » Starters: Otis Lambeth vs Doc Ayers | Fifth | 6 out |
| Future Indian Ray Mack is born in Cleveland, OH. |
| Saturday, September 2 |
| » Defeated Browns (69-59), 5-4 | League Park II (35-23) | 68-60 | |
| » Starters: Dave Davenport vs Joe Boehling | Fifth | 5½ out |
| Sunday, September 3 |
| » Lost to Tigers (72-57), 5-3 | Tiger Stadium (5-4) | 68-61 | |
| » Starters: Jim Bagby vs Hooks Dauss | Sixth | 6 out |
| Monday, September 4 |
| » Lost to Tigers (73-57), 11-8 | Tiger Stadium (5-5) | 68-62 | Lost 2 |
| » Starters: Stan Coveleski vs Bernie Boland | Sixth | 7 out |
| » Lost to Tigers (74-57), 7-5 | Tiger Stadium (5-6) | 68-63 | Lost 3 |
| » Starters: Guy Morton vs Willie Mitchell | Sixth | 7 out |
| Wednesday, September 6 |
| » Lost to White Sox (73-58), 4-3 | Comiskey Park I (4-4) | 68-64 | Lost 4 |
| » Starters: Joe Boehling vs Reb Russell | Sixth | 8 out |
| Thursday, September 7 |
| » Lost to White Sox (74-58), 5-3 | Comiskey Park I (4-5) | 68-65 | Lost 5 |
| » Starters: Jim Bagby vs Red Faber | Sixth | 9 out |
| Friday, September 8 |
| » Lost to White Sox (75-58), 3-2 | Comiskey Park I (4-6) | 68-66 | Lost 6 |
| » Starters: Fritz Coumbe vs Joe Benz | Seventh | 9½ out |
| Future Indian Jim Bagby Jr. is born in Cleveland, OH. |
| Saturday, September 9 |
| » Lost to White Sox (76-58), 5-4 | Comiskey Park I (4-7) | 68-67 | Lost 7 |
| » Starters: Otis Lambeth vs Lefty Williams | Seventh | 10 out |
| Sunday, September 10 |
| » Defeated Tigers (77-59), 8-2 | League Park II (36-23) | 69-67 | |
| » Starters: Bill James vs Guy Morton | Seventh | 9½ out |
| Monday, September 11 |
| » Lost to Tigers (78-59), 9-1 | League Park II (36-24) | 69-68 | |
| » Starters: Hooks Dauss vs Joe Boehling | Sixth | 10½ out |
| » Major-league debuts: Ken Penner (Indians) |
| Tuesday, September 12 |
| » Lost to Tigers (79-59), 10-2 | League Park II (36-25) | 69-69 | Lost 2 |
| » Starters: Howard Ehmke vs Stan Coveleski | Seventh | 10½ out |
| » Major-league debuts: Hank DeBerry (Indians) |
| Wednesday, September 13 |
| » Defeated Athletics (30-104), 8-4 | League Park II (37-25) | 70-69 | |
| » Starters: Elmer Myers vs Fred Beebe | Seventh | 10 out |
| » Major-league debuts: Roy Grover (Athletics) |
| Thursday, September 14 |
| » Defeated Athletics (30-105), 9-1 | League Park II (38-25) | 71-69 | Won 2 |
| » Starters: Jack Nabors vs Al Gould | Sixth | 9 out |
| Friday, September 15 |
| » Defeated Athletics (30-106), 3-2 | League Park II (39-25) | 72-69 | Won 3 |
| » Starters: Tom Sheehan vs Ken Penner | Sixth | 9 out |
| Saturday, September 16 |
| » Lost to Yankees (73-66), 4-3 | League Park II (39-26) | 72-70 | |
| » Starters: Ray Fisher vs Otis Lambeth | Sixth | 10 out |
| Sunday, September 17 |
| » Defeated Yankees (73-67), 9-7 | League Park II (40-26) | 73-70 | |
| » Starters: Bob Shawkey vs Pop-boy Smith | Sixth | 10 out |
| Tuesday, September 19 |
| » Lost to Senators (71-69), 9-6 | League Park II (40-27) | 73-71 | |
| » Starters: Bert Gallia vs Jim Bagby | Sixth | 10½ out |
| Wednesday, September 20 |
| » Defeated Senators (71-70), 3-2 | League Park II (41-27) | 74-71 | |
| » Starters: Doc Ayers vs Joe Boehling | Sixth | 10½ out |
| Thursday, September 21 |
| » Defeated Senators (71-71), 3-2 | League Park II (42-27) | 75-71 | Won 2 |
| » Starters: Walter Johnson vs Pop-boy Smith | Fifth | 10½ out |
| Friday, September 22 |
| » Lost to Red Sox (85-59), 4-1 | League Park II (42-28) | 75-72 | |
| » Starters: Ernie Shore vs Jim Bagby | Sixth | 11½ out |
| Saturday, September 23 |
| » Lost to Red Sox (86-59), 5-3 | League Park II (42-29) | 75-73 | Lost 2 |
| » Starters: Carl Mays vs Otis Lambeth | Sixth | 12½ out |
| Sunday, September 24 |
| » Defeated Red Sox (86-60), 5-3 | League Park II (43-29) | 76-73 | |
| » Starters: Dutch Leonard vs Joe Boehling | Sixth | 11½ out |
| Monday, September 25 |
| » Lost to Red Sox (87-60), 2-0 | League Park II (43-30) | 76-74 | |
| » Starters: Babe Ruth vs Pop-boy Smith | Sixth | 12½ out |
| Saturday, September 30 |
| » Lost to White Sox (87-64), 7-2 | League Park II (43-31) | 76-75 | Lost 2 |
| » Starters: Reb Russell vs Jim Bagby | Seventh | 14½ out |
| » Lost to White Sox (88-64), 7-3 | League Park II (43-32) | 76-76 | Lost 3 |
| » Starters: Lefty Williams vs Joe Boehling | Seventh | 14½ out |
| Sunday, October 1 |
| » Defeated White Sox (88-65), 2-0 | League Park II (44-32) | 77-76 | |
| » Starters: Red Faber vs Fritz Coumbe | Seventh | 14½ out |
| » Lost to White Sox (89-65), 8-4 | League Park II (44-33) | 77-77 | |
| » Starters: Eddie Cicotte vs Ken Penner | Seventh | 14½ out |
| Tuesday, October 3 |
| » Major-league debuts: Axel Lindstrom (Athletics) |
| Tuesday, October 31 |
| Future Indian Ken Keltner is born in Milwaukee, WI. |
| Wednesday, December 13 |
| Future Indian Hank Majeski is born in Staten Island, NY. |
| Wednesday, December 27 |
| Future Indian Charlie Brewster is born in Marthaville, LA. |
Game information provided by Retrosheet (www.retrosheet.org) |