| Sunday, January 3 |
| Future Red Sox Sid Hudson is born in Coalfield, TN. |
| Thursday, January 7 |
| Future Red Sox Red Steiner is born in Los Angeles, CA. |
| Tuesday, January 26 |
| Future Red Sox Rip Russell is born in Los Angeles, CA. |
| Friday, February 5 |
| Former Red Sox Ross Barnes dies in Chicago, IL at the age of 65. |
| Friday, February 26 |
| Future Red Sox Bill Conroy is born in Bloomington, IL. |
| Saturday, March 20 |
| Future Red Sox Stan Spence is born in South Portsmouth, KY. |
| Wednesday, April 14 |
| » Lost to Athletics (1-0), 2-0 | Shibe Park (0-1) | 0-1 | |
| » Starters: Ernie Shore vs Herb Pennock | Second | 1 out |
| Thursday, April 15 |
| » Defeated Athletics (1-1), 5-3 | Shibe Park (1-1) | 1-1 | |
| » Starters: Ray Collins vs Bullet Joe Bush | Second | 1 out |
| » Major-league debuts: Carl Mays (Red Sox) |
| Friday, April 16 |
| » Tied Athletics, 6-6 | Shibe Park (1-1) | 1-1 | |
| » Starters: Babe Ruth vs Rube Bressler | Second | ½ out |
| Saturday, April 17 |
| » Defeated Senators (2-2), 7-5 | Griffith Stadium (1-0) | 2-1 | Won 2 |
| » Starters: Rube Foster vs Joe Boehling | First | -- |
| Monday, April 19 |
| » Lost to Senators (3-2), 4-2 | Griffith Stadium (1-1) | 2-2 | |
| » Starters: Carl Mays vs Walter Johnson | Third | 1 out |
| Tuesday, April 20 |
| » Defeated Senators (3-3), 5-2 | Griffith Stadium (2-1) | 3-2 | |
| » Starters: Rube Foster vs Bert Gallia | Second | 1 out |
| Wednesday, April 21 |
| » Lost to Senators (4-3), 11-3 | Griffith Stadium (2-2) | 3-3 | |
| » Starters: Ray Collins vs Joe Boehling | Fourth | 2 out |
| » Major-league debuts: Mike McNally (Red Sox) |
| Thursday, April 22 |
| » Defeated Athletics (2-5), 7-6 | Fenway Park (1-0) | 4-3 | |
| » Starters: Weldon Wyckoff vs Ernie Shore | Third | 2 out |
| Saturday, April 24 |
| » Lost to Athletics (3-5), 6-3 | Fenway Park (1-1) | 4-4 | |
| » Starters: Herb Pennock vs Dutch Leonard | Third | 3½ out |
| Monday, April 26 |
| » Defeated Athletics (3-6), 9-2 | Fenway Park (2-1) | 5-4 | |
| » Starters: Chick Davies vs Babe Ruth | Third | 2 out |
| Tuesday, April 27 |
| » Lost to Yankees (7-4), 2-0 | Fenway Park (2-2) | 5-5 | |
| » Starters: Ray Keating vs Rube Foster | Fifth | 3 out |
| Thursday, April 29 |
| » Lost to Yankees (8-4), 6-4 | Fenway Park (2-3) | 5-6 | Lost 2 |
| » Starters: Marty McHale vs Ernie Shore | Fifth | 4½ out |
| Tuesday, May 4 |
| » Defeated Senators (8-7), 2-0 | Fenway Park (3-3) | 6-6 | |
| » Starters: Walter Johnson vs Rube Foster | Fifth | 3 out |
| Wednesday, May 5 |
| » Defeated Senators (8-8), 1-0 | Fenway Park (4-3) | 7-6 | Won 2 |
| » Starters: Joe Boehling vs Ernie Shore | Fourth | 4 out |
| Thursday, May 6 |
| » Lost to Yankees (11-5), 4-3 | Polo Grounds V (0-1) | 7-7 | |
| » Starters: Babe Ruth vs Jack Warhop | Fifth | 4½ out |
| Friday, May 7 |
| » Defeated Yankees (11-6), 5-3 | Polo Grounds V (1-1) | 8-7 | |
| » Starters: Dutch Leonard vs Ray Caldwell | Fourth | 4½ out |
| Saturday, May 8 |
| » Lost to Yankees (12-6), 10-3 | Polo Grounds V (1-2) | 8-8 | |
| » Starters: Ray Collins vs Ray Fisher | Fourth | 4½ out |
| Monday, May 10 |
| » Defeated Yankees (12-7), 3-1 | Polo Grounds V (2-2) | 9-8 | |
| » Starters: Rube Foster vs Marty McHale | Fourth | 4½ out |
| Tuesday, May 11 |
| » Lost to Tigers (18-7), 5-1 | Tiger Stadium (0-1) | 9-9 | |
| » Starters: Babe Ruth vs Hooks Dauss | Fourth | 5½ out |
| Wednesday, May 12 |
| » Defeated Tigers (18-8), 4-1 | Tiger Stadium (1-1) | 10-9 | |
| » Starters: Ernie Shore vs Harry Coveleski | Fourth | 4½ out |
| Thursday, May 13 |
| » Defeated Tigers (18-9), 4-2 | Tiger Stadium (2-1) | 11-9 | Won 2 |
| » Starters: Dutch Leonard vs Bernie Boland | Fourth | 3½ out |
| Saturday, May 15 |
| » Defeated Tigers (18-10), 5-2 | Tiger Stadium (3-1) | 12-9 | Won 3 |
| » Starters: Rube Foster vs Jean Dubuc | Fourth | 2 out |
| Sunday, May 16 |
| » Defeated Indians (11-16), 3-0 | League Park II (1-0) | 13-9 | Won 4 |
| » Starters: Joe Wood vs Guy Morton | Third | 2 out |
| Wednesday, May 19 |
| » Lost to Indians (12-16), 5-2 | League Park II (1-1) | 13-10 | |
| » Starters: Rube Foster vs Rip Hagerman | Fourth | 2 out |
| Friday, May 21 |
| » Lost to White Sox (20-12), 3-2 | Comiskey Park I (0-1) | 13-11 | Lost 2 |
| » Starters: Ernie Shore vs Reb Russell | Fourth | 2½ out |
| Saturday, May 22 |
| » Lost to White Sox (21-12), 11-3 | Comiskey Park I (0-2) | 13-12 | Lost 3 |
| » Starters: Babe Ruth vs Joe Benz | Fourth | 4 out |
| Future Red Sox Pinky Woods is born in Waterbury, CT. |
| Sunday, May 23 |
| » Lost to White Sox (22-12), 4-2 | Comiskey Park I (0-3) | 13-13 | Lost 4 |
| » Starters: Joe Wood vs Jim Scott | Fourth | 5 out |
| Monday, May 24 |
| » Lost to Browns (14-20), 4-3 | Sportsman's Park III (0-1) | 13-14 | Lost 5 |
| » Starters: Rube Foster vs Grover Lowdermilk | Fourth | 6 out |
| Friday, May 28 |
| » Defeated Athletics (12-23), 8-5 | Shibe Park (2-1) | 14-14 | |
| » Starters: Carl Mays vs Bob Shawkey | Fourth | 6½ out |
| Saturday, May 29 |
| » Lost to Athletics (13-23), 2-1 | Shibe Park (2-2) | 14-15 | |
| » Starters: Babe Ruth vs Weldon Wyckoff | Fourth | 6½ out |
| » Defeated Athletics (13-24), 6-5 | Shibe Park (3-2) | 15-15 | |
| » Starters: Ernie Shore vs Rube Bressler | Fourth | 6½ out |
| Monday, May 31 |
| » Defeated Athletics (13-25), 2-1 | Shibe Park (4-2) | 16-15 | Won 2 |
| » Starters: Rube Foster vs Bullet Joe Bush | Fourth | 5 out |
| » Defeated Athletics (13-26), 9-2 | Shibe Park (5-2) | 17-15 | Won 3 |
| » Starters: Carl Mays vs Bob Shawkey | Fourth | 5 out |
| Tuesday, June 1 |
| » Defeated Yankees (19-16), 4-3 | Polo Grounds V (3-2) | 18-15 | Won 4 |
| » Starters: Joe Wood vs Ray Keating | Third | 5 out |
| Wednesday, June 2 |
| » Defeated Yankees (19-17), 7-1 | Polo Grounds V (4-2) | 19-15 | Won 5 |
| » Starters: Babe Ruth vs Jack Warhop | Third | 4 out |
| Friday, June 4 |
| » Lost to White Sox (28-15), 2-0 | Fenway Park (4-4) | 19-16 | |
| » Starters: Jim Scott vs Ernie Shore | Third | 5 out |
| Saturday, June 5 |
| » Defeated White Sox (28-16), 4-2 | Fenway Park (5-4) | 20-16 | |
| » Starters: Reb Russell vs Rube Foster | Third | 4 out |
| Monday, June 7 |
| » Defeated White Sox (28-17), 3-0 | Fenway Park (6-4) | 21-16 | Won 2 |
| » Starters: Red Faber vs Joe Wood | Third | 5 out |
| Tuesday, June 8 |
| » Lost to White Sox (29-17), 4-3 | Fenway Park (6-5) | 21-17 | |
| » Starters: Joe Benz vs Carl Mays | Third | 4 out |
| Wednesday, June 9 |
| » Lost to Tigers (31-18), 15-0 | Fenway Park (6-6) | 21-18 | Lost 2 |
| » Starters: Hooks Dauss vs Ray Collins | Third | 5 out |
| Thursday, June 10 |
| » Defeated Tigers (31-19), 6-5 | Fenway Park (7-6) | 22-18 | |
| » Starters: Harry Coveleski vs Ernie Shore | Third | 5 out |
| Friday, June 11 |
| » Defeated Tigers (31-20), 4-3 | Fenway Park (8-6) | 23-18 | Won 2 |
| » Starters: Hooks Dauss vs Rube Foster | Third | 4 out |
| Saturday, June 12 |
| » Defeated Indians (20-26), 5-4 | Fenway Park (9-6) | 24-18 | Won 3 |
| » Starters: Fritz Coumbe vs Vean Gregg | Third | 4 out |
| Monday, June 14 |
| » Defeated Indians (20-27), 4-1 | Fenway Park (10-6) | 25-18 | Won 4 |
| » Starters: Willie Mitchell vs Joe Wood | Third | 4 out |
| Wednesday, June 16 |
| » Defeated Indians (20-28), 4-3 | Fenway Park (11-6) | 26-18 | Won 5 |
| » Starters: Guy Morton vs Ernie Shore | Third | 4 out |
| Thursday, June 17 |
| » Defeated Browns (19-33), 11-10 | Fenway Park (12-6) | 27-18 | Won 6 |
| » Starters: Parson Perryman vs Babe Ruth | Third | 4 out |
| Friday, June 18 |
| » Defeated Browns (19-34), 3-1 | Fenway Park (13-6) | 28-18 | Won 7 |
| » Starters: Earl Hamilton vs Rube Foster | Second | 4 out |
| Saturday, June 19 |
| » Tied Browns, 5-5 | Fenway Park (13-6) | 28-18 | |
| » Starters: Grover Lowdermilk vs Vean Gregg | Second | 4½ out |
| Monday, June 21 |
| » Defeated Senators (24-25), 8-3 | Griffith Stadium (3-2) | 29-18 | Won 8 |
| » Starters: Babe Ruth vs Jim Shaw | Second | 4½ out |
| » Lost to Senators (25-25), 6-5 | Griffith Stadium (3-3) | 29-19 | |
| » Starters: Ernie Shore vs Joe Boehling | Second | 4½ out |
| Tuesday, June 22 |
| » Lost to Senators (26-25), 7-4 | Griffith Stadium (3-4) | 29-20 | Lost 2 |
| » Starters: Rube Foster vs Doc Ayers | Second | 4½ out |
| Wednesday, June 23 |
| » Lost to Senators (27-25), 5-0 | Griffith Stadium (3-5) | 29-21 | Lost 3 |
| » Starters: Carl Mays vs Walter Johnson | Third | 6 out |
| Future Red Sox Aaron Robinson is born in Lancaster, SC. |
| Thursday, June 24 |
| » Defeated Senators (27-26), 12-4 | Griffith Stadium (4-5) | 30-21 | |
| » Starters: Ray Collins vs Joe Boehling | Third | 6 out |
| Friday, June 25 |
| » Defeated Yankees (30-27), 9-5 | Fenway Park (14-6) | 31-21 | Won 2 |
| » Starters: Ray Caldwell vs Babe Ruth | Second | 5½ out |
| Saturday, June 26 |
| » Lost to Yankees (31-27), 5-1 | Fenway Park (14-7) | 31-22 | |
| » Starters: Jack Warhop vs Rube Foster | Second | 5 out |
| » Defeated Yankees (31-28), 4-2 | Fenway Park (15-7) | 32-22 | |
| » Starters: Boardwalk Brown vs Joe Wood | Second | 5 out |
| Monday, June 28 |
| » Lost to Yankees (32-28), 3-2 | Fenway Park (15-8) | 32-23 | |
| » Starters: Ray Fisher vs Ernie Shore | Third | 6 out |
| » Defeated Yankees (32-29), 6-3 | Fenway Park (16-8) | 33-23 | |
| » Starters: Marty McHale vs Vean Gregg | Third | 6 out |
| Tuesday, June 29 |
| » Defeated Yankees (32-30), 4-3 | Fenway Park (17-8) | 34-23 | Won 2 |
| » Starters: Ray Caldwell vs Babe Ruth | Second | 6 out |
| Future Red Sox Dizzy Trout is born in Sandcut, IN. |
| Wednesday, June 30 |
| » Defeated Athletics (22-41), 10-5 | Fenway Park (18-8) | 35-23 | Won 3 |
| » Starters: Bruno Haas vs Rube Foster | Second | 5½ out |
| » Defeated Athletics (22-42), 10-7 | Fenway Park (19-8) | 36-23 | Won 4 |
| » Starters: Rube Bressler vs Herb Pennock | Second | 5½ out |
| Friday, July 2 |
| Future Red Sox Hal Wagner is born in East Riverton, NJ. |
| Saturday, July 3 |
| » Lost to Athletics (23-42), 7-3 | Fenway Park (19-9) | 36-24 | |
| » Starters: Cap Crowell vs Ray Collins | Second | 5 out |
| » Defeated Athletics (23-43), 11-0 | Fenway Park (20-9) | 37-24 | |
| » Starters: Weldon Wyckoff vs Joe Wood | Second | 5 out |
| Monday, July 5 |
| » Defeated Senators (32-31), 4-0 | Fenway Park (21-9) | 38-24 | Won 2 |
| » Starters: Doc Ayers vs Rube Foster | Second | 4½ out |
| » Defeated Senators (32-32), 6-0 | Fenway Park (22-9) | 39-24 | Won 3 |
| » Starters: Jim Shaw vs Babe Ruth | Second | 4½ out |
| Tuesday, July 6 |
| » Defeated Senators (32-33), 5-1 | Fenway Park (23-9) | 40-24 | Won 4 |
| » Starters: Joe Boehling vs Ernie Shore | Second | 4 out |
| » Defeated Senators (32-34), 4-1 | Fenway Park (24-9) | 41-24 | Won 5 |
| » Starters: Walter Johnson vs Vean Gregg | Second | 4 out |
| Wednesday, July 7 |
| » Defeated Senators (32-35), 9-4 | Fenway Park (25-9) | 42-24 | Won 6 |
| » Starters: Bert Gallia vs Joe Wood | Second | 3 out |
| » Defeated Senators (32-36), 1-0 | Fenway Park (26-9) | 43-24 | Won 7 |
| » Starters: Joe Engel vs Dutch Leonard | Second | 3 out |
| Friday, July 9 |
| » Lost to Tigers (45-28), 15-4 | Tiger Stadium (3-2) | 43-25 | |
| » Starters: Babe Ruth vs Harry Coveleski | Second | 3 out |
| Saturday, July 10 |
| » Defeated Tigers (45-29), 6-3 | Tiger Stadium (4-2) | 44-25 | |
| » Starters: Rube Foster vs Jean Dubuc | Second | 2½ out |
| Future Red Sox George Dickey is born in Kensett, AR. |
| Sunday, July 11 |
| » Lost to Tigers (46-29), 5-4 | Tiger Stadium (4-3) | 44-26 | |
| » Starters: Ernie Shore vs Hooks Dauss | Second | 3 out |
| Monday, July 12 |
| » Defeated Tigers (46-30), 15-12 | Tiger Stadium (5-3) | 45-26 | |
| » Starters: Dutch Leonard vs Harry Coveleski | Second | 3 out |
| Tuesday, July 13 |
| » Defeated Indians (26-47), 7-3 | League Park II (2-1) | 46-26 | Won 2 |
| » Starters: Babe Ruth vs Roy Walker | Second | 2½ out |
| » Lost to Indians (27-47), 6-5 | League Park II (2-2) | 46-27 | |
| » Starters: Carl Mays vs Willie Mitchell | Second | 2½ out |
| Wednesday, July 14 |
| » Lost to Indians (28-47), 3-2 | League Park II (2-3) | 46-28 | Lost 2 |
| » Starters: Joe Wood vs Guy Morton | Second | 2 out |
| » Defeated Indians (28-48), 7-1 | League Park II (3-3) | 47-28 | |
| » Starters: Ray Collins vs Fritz Coumbe | Second | 2 out |
| Thursday, July 15 |
| » Defeated Indians (28-49), 4-3 | League Park II (4-3) | 48-28 | Won 2 |
| » Starters: Ernie Shore vs Rip Hagerman | Second | 2 out |
| Saturday, July 17 |
| » Defeated White Sox (52-30), 6-4 | Comiskey Park I (1-3) | 49-28 | Won 3 |
| » Starters: Rube Foster vs Jim Scott | Second | 2½ out |
| » Lost to White Sox (53-30), 4-0 | Comiskey Park I (1-4) | 49-29 | |
| » Starters: Dutch Leonard vs Reb Russell | Second | 2½ out |
| Sunday, July 18 |
| » Defeated White Sox (53-31), 6-2 | Comiskey Park I (2-4) | 50-29 | |
| » Starters: Joe Wood vs Red Faber | First | -- |
| Monday, July 19 |
| » Defeated White Sox (53-32), 6-4 | Comiskey Park I (3-4) | 51-29 | Won 2 |
| » Starters: Ray Collins vs Joe Benz | First | -- |
| Tuesday, July 20 |
| » Defeated White Sox (53-33), 3-0 | Comiskey Park I (4-4) | 52-29 | Won 3 |
| » Starters: Ernie Shore vs Eddie Cicotte | First | -- |
| Wednesday, July 21 |
| » Defeated Browns (33-50), 4-2 | Sportsman's Park III (1-1) | 53-29 | Won 4 |
| » Starters: Babe Ruth vs Bill James | First | -- |
| Thursday, July 22 |
| » Defeated Browns (33-51), 7-3 | Sportsman's Park III (2-1) | 54-29 | Won 5 |
| » Starters: Rube Foster vs Grover Lowdermilk | First | -- |
| Friday, July 23 |
| » Defeated Browns (33-52), 8-3 | Sportsman's Park III (3-1) | 55-29 | Won 6 |
| » Starters: Dutch Leonard vs Grover Lowdermilk | First | -- |
| Saturday, July 24 |
| » Defeated Browns (33-53), 7-3 | Sportsman's Park III (4-1) | 56-29 | Won 7 |
| » Starters: Rube Foster vs Earl Hamilton | First | -- |
| » Lost to Browns (34-53), 3-2 | Sportsman's Park III (4-2) | 56-30 | |
| » Starters: Ernie Shore vs Carl Weilman | First | -- |
| Sunday, July 25 |
| » Lost to Browns (35-53), 9-8 | Sportsman's Park III (4-3) | 56-31 | Lost 2 |
| » Starters: Babe Ruth vs Bill James | First | -- |
| » Tied Browns, 1-1 | Sportsman's Park III (4-3) | 56-31 | |
| » Starters: Dutch Leonard vs Ernie Koob | First | -- |
| Monday, July 26 |
| Future Red Sox Mel Deutsch is born in Caldwell, TX. |
| Tuesday, July 27 |
| » Defeated White Sox (56-34), 3-1 | Fenway Park (27-9) | 57-31 | |
| » Starters: Reb Russell vs Joe Wood | First | -- |
| Wednesday, July 28 |
| » Lost to White Sox (57-34), 1-0 | Fenway Park (27-10) | 57-32 | |
| » Starters: Jim Scott vs Ernie Shore | First | -- |
| Friday, July 30 |
| » Lost to Tigers (57-35), 7-6 | Fenway Park (27-11) | 57-33 | Lost 2 |
| » Starters: Hooks Dauss vs Dutch Leonard | First | -- |
| Saturday, July 31 |
| » Defeated Tigers (57-36), 4-1 | Fenway Park (28-11) | 58-33 | |
| » Starters: Harry Coveleski vs Rube Foster | First | -- |
| Monday, August 2 |
| » Lost to Tigers (58-36), 5-3 | Fenway Park (28-12) | 58-34 | |
| » Starters: Hooks Dauss vs Ray Collins | First | -- |
| Tuesday, August 3 |
| » Defeated Tigers (58-37), 2-1 | Fenway Park (29-12) | 59-34 | |
| » Starters: Harry Coveleski vs Ernie Shore | First | -- |
| Saturday, August 7 |
| » Defeated Indians (37-58), 2-0 | Fenway Park (30-12) | 60-34 | Won 2 |
| » Starters: Guy Morton vs Joe Wood | First | -- |
| » Defeated Indians (37-59), 6-2 | Fenway Park (31-12) | 61-34 | Won 3 |
| » Starters: Roy Walker vs Dutch Leonard | First | -- |
| Monday, August 9 |
| » Defeated Browns (39-60), 2-0 | Fenway Park (32-12) | 62-34 | Won 4 |
| » Starters: Carl Weilman vs Rube Foster | First | -- |
| Tuesday, August 10 |
| » Lost to Browns (40-60), 3-2 | Fenway Park (32-13) | 62-35 | |
| » Starters: Ernie Koob vs Ernie Shore | First | -- |
| » Defeated Browns (40-61), 10-3 | Fenway Park (33-13) | 63-35 | |
| » Starters: Grover Lowdermilk vs Babe Ruth | First | -- |
| Wednesday, August 11 |
| » Defeated Browns (40-62), 11-3 | Fenway Park (34-13) | 64-35 | Won 2 |
| » Starters: Earl Hamilton vs Joe Wood | First | -- |
| » Defeated Browns (40-63), 2-1 | Fenway Park (35-13) | 65-35 | Won 3 |
| » Starters: Bill James vs Dutch Leonard | First | -- |
| Thursday, August 12 |
| » Defeated Browns (40-64), 4-0 | Fenway Park (36-13) | 66-35 | Won 4 |
| » Starters: Carl Weilman vs Rube Foster | First | -- |
| Friday, August 13 |
| » Defeated Senators (54-50), 3-2 | Fenway Park (37-13) | 67-35 | Won 5 |
| » Starters: Joe Boehling vs Ernie Shore | First | -- |
| Saturday, August 14 |
| » Defeated Senators (54-51), 4-3 | Fenway Park (38-13) | 68-35 | Won 6 |
| » Starters: Walter Johnson vs Babe Ruth | First | -- |
| Monday, August 16 |
| » Defeated Senators (54-52), 1-0 | Fenway Park (39-13) | 69-35 | Won 7 |
| » Starters: Bert Gallia vs Joe Wood | First | -- |
| Wednesday, August 18 |
| » Lost to White Sox (65-42), 5-3 | Comiskey Park I (4-5) | 69-36 | |
| » Starters: Dutch Leonard vs Reb Russell | First | -- |
| Thursday, August 19 |
| » Lost to White Sox (66-42), 2-1 | Comiskey Park I (4-6) | 69-37 | Lost 2 |
| » Starters: Rube Foster vs Red Faber | First | -- |
| Friday, August 20 |
| » Defeated White Sox (66-43), 4-1 | Comiskey Park I (5-6) | 70-37 | |
| » Starters: Ernie Shore vs Joe Benz | First | -- |
| Saturday, August 21 |
| » Defeated Browns (41-69), 4-1 | Sportsman's Park III (5-3) | 71-37 | Won 2 |
| » Starters: Babe Ruth vs Carl Weilman | First | -- |
| Sunday, August 22 |
| » Defeated Browns (41-70), 6-1 | Sportsman's Park III (6-3) | 72-37 | Won 3 |
| » Starters: Rube Foster vs Ernie Koob | First | -- |
| » Defeated Browns (41-71), 5-3 | Sportsman's Park III (7-3) | 73-37 | Won 4 |
| » Starters: Dutch Leonard vs Grover Lowdermilk | First | -- |
| Monday, August 23 |
| » Defeated Browns (41-72), 7-0 | Sportsman's Park III (8-3) | 74-37 | Won 5 |
| » Starters: Vean Gregg vs Earl Hamilton | First | -- |
| Tuesday, August 24 |
| » Defeated Tigers (74-41), 3-1 | Tiger Stadium (6-3) | 75-37 | Won 6 |
| » Starters: Ernie Shore vs Harry Coveleski | First | -- |
| Wednesday, August 25 |
| » Defeated Tigers (74-42), 2-1 | Tiger Stadium (7-3) | 76-37 | Won 7 |
| » Starters: Babe Ruth vs Bill James | First | -- |
| Thursday, August 26 |
| » Lost to Tigers (75-42), 7-6 | Tiger Stadium (7-4) | 76-38 | |
| » Starters: Rube Foster vs Hooks Dauss | First | -- |
| Friday, August 27 |
| » Lost to Indians (45-71), 4-3 | League Park II (4-4) | 76-39 | Lost 2 |
| » Starters: Vean Gregg vs Willie Mitchell | First | -- |
| Saturday, August 28 |
| » Defeated Indians (45-72), 5-3 | League Park II (5-4) | 77-39 | |
| » Starters: Babe Ruth vs Guy Morton | First | -- |
| » Defeated Indians (45-73), 3-1 | League Park II (6-4) | 78-39 | Won 2 |
| » Starters: Ernie Shore vs Allan Collamore | First | -- |
| Sunday, August 29 |
| » Defeated Indians (45-74), 1-0 | League Park II (7-4) | 79-39 | Won 3 |
| » Starters: Dutch Leonard vs Ed Klepfer | First | -- |
| Future Red Sox Ford Garrison is born in Greenville, SC. |
| Wednesday, September 1 |
| » Defeated Athletics (36-82), 6-0 | Shibe Park (6-2) | 80-39 | Won 4 |
| » Starters: Rube Foster vs Weldon Wyckoff | First | -- |
| Thursday, September 2 |
| » Defeated Athletics (36-83), 8-3 | Shibe Park (7-2) | 81-39 | Won 5 |
| » Starters: Babe Ruth vs Tom Knowlson | First | -- |
| Friday, September 3 |
| » Defeated Athletics (36-84), 10-2 | Shibe Park (8-2) | 82-39 | Won 6 |
| » Starters: Ernie Shore vs Tom Sheehan | First | -- |
| Saturday, September 4 |
| » Defeated Athletics (36-85), 3-2 | Shibe Park (9-2) | 83-39 | Won 7 |
| » Starters: Dutch Leonard vs Bullet Joe Bush | First | -- |
| Monday, September 6 |
| » Lost to Yankees (57-65), 4-0 | Fenway Park (39-14) | 83-40 | |
| » Starters: Ray Fisher vs Rube Foster | First | -- |
| » Lost to Yankees (58-65), 5-2 | Fenway Park (39-15) | 83-41 | Lost 2 |
| » Starters: Ray Caldwell vs Babe Ruth | First | -- |
| Tuesday, September 7 |
| » Lost to Yankees (59-65), 8-3 | Fenway Park (39-16) | 83-42 | Lost 3 |
| » Starters: George Mogridge vs Ernie Shore | First | -- |
| Wednesday, September 8 |
| » Lost to Athletics (38-88), 1-0 | Fenway Park (39-17) | 83-43 | Lost 4 |
| » Starters: Tom Sheehan vs Dutch Leonard | First | -- |
| » Defeated Athletics (38-89), 13-2 | Fenway Park (40-17) | 84-43 | |
| » Starters: Cap Crowell vs Vean Gregg | First | -- |
| Thursday, September 9 |
| » Defeated Athletics (38-90), 5-0 | Fenway Park (41-17) | 85-43 | Won 2 |
| » Starters: Tom Knowlson vs Ernie Shore | First | -- |
| Friday, September 10 |
| » Defeated Athletics (38-91), 7-2 | Fenway Park (42-17) | 86-43 | Won 3 |
| » Starters: Weldon Wyckoff vs Babe Ruth | First | -- |
| Saturday, September 11 |
| » Defeated White Sox (79-53), 5-4 | Fenway Park (43-17) | 87-43 | Won 4 |
| » Starters: Reb Russell vs Rube Foster | First | -- |
| Monday, September 13 |
| » Defeated White Sox (79-54), 2-1 | Fenway Park (44-17) | 88-43 | Won 5 |
| » Starters: Jim Scott vs Dutch Leonard | First | -- |
| » Defeated White Sox (79-55), 4-1 | Fenway Park (45-17) | 89-43 | Won 6 |
| » Starters: Red Faber vs Ernie Shore | First | -- |
| Tuesday, September 14 |
| » Defeated White Sox (79-56), 2-1 | Fenway Park (46-17) | 90-43 | Won 7 |
| » Starters: Joe Benz vs Babe Ruth | First | -- |
| Wednesday, September 15 |
| » Lost to White Sox (80-56), 3-1 | Fenway Park (46-18) | 90-44 | |
| » Starters: Red Faber vs Vean Gregg | First | -- |
| Thursday, September 16 |
| » Lost to Tigers (91-48), 6-1 | Fenway Park (46-19) | 90-45 | Lost 2 |
| » Starters: Hooks Dauss vs Rube Foster | First | -- |
| Friday, September 17 |
| » Defeated Tigers (91-49), 7-2 | Fenway Park (47-19) | 91-45 | |
| » Starters: Bill James vs Dutch Leonard | First | -- |
| Saturday, September 18 |
| » Defeated Tigers (91-50), 1-0 | Fenway Park (48-19) | 92-45 | Won 2 |
| » Starters: Harry Coveleski vs Ernie Shore | First | -- |
| Monday, September 20 |
| » Defeated Tigers (91-51), 3-2 | Fenway Park (49-19) | 93-45 | Won 3 |
| » Starters: Hooks Dauss vs Babe Ruth | First | -- |
| Wednesday, September 22 |
| » Defeated Indians (54-88), 3-2 | Fenway Park (50-19) | 94-45 | Won 4 |
| » Starters: Sad Sam Jones vs Dutch Leonard | First | -- |
| » Defeated Indians (54-89), 7-1 | Fenway Park (51-19) | 95-45 | Won 5 |
| » Starters: Willie Mitchell vs Rube Foster | First | -- |
| » Major-league debuts: Chick Shorten (Red Sox) |
| Thursday, September 23 |
| » Defeated Indians (54-90), 5-4 | Fenway Park (52-19) | 96-45 | Won 6 |
| » Starters: Ed Klepfer vs Joe Wood | First | -- |
| » Defeated Indians (54-91), 6-2 | Fenway Park (53-19) | 97-45 | Won 7 |
| » Starters: Lynn Brenton vs Ernie Shore | First | -- |
| Friday, September 24 |
| » Lost to Browns (62-84), 8-4 | Fenway Park (53-20) | 97-46 | |
| » Starters: Ernie Koob vs Babe Ruth | First | -- |
| Saturday, September 25 |
| » Defeated Browns (62-85), 3-2 | Fenway Park (54-20) | 98-46 | |
| » Starters: Earl Hamilton vs Rube Foster | First | -- |
| Monday, September 27 |
| » Defeated Browns (62-86), 8-4 | Fenway Park (55-20) | 99-46 | Won 2 |
| » Starters: George Sisler vs Dutch Leonard | First | -- |
| Saturday, October 2 |
| » Lost to Senators (84-66), 3-1 | Griffith Stadium (4-6) | 99-47 | |
| » Starters: Joe Wood vs Walter Johnson | First | -- |
| » Tied Senators, 3-3 | Griffith Stadium (4-6) | 99-47 | |
| » Starters: Ernie Shore vs George Dumont | First | -- |
| Monday, October 4 |
| » Lost to Yankees (67-81), 5-1 | Polo Grounds V (4-3) | 99-48 | Lost 2 |
| » Starters: Dutch Leonard vs Cliff Markle | First | -- |
| » Lost to Yankees (68-81), 3-2 | Polo Grounds V (4-4) | 99-49 | Lost 3 |
| » Starters: Rube Foster vs Ray Caldwell | First | -- |
| Wednesday, October 6 |
| » Defeated Yankees (68-82), 2-0 | Polo Grounds V (5-4) | 100-49 | |
| » Starters: Ernie Shore vs George Mogridge | First | -- |
| » Defeated Yankees (68-83), 4-2 | Polo Grounds V (6-4) | 101-49 | Won 2 |
| » Starters: Babe Ruth vs Dan Tipple | First | -- |
| Thursday, October 7 |
| » Lost to Yankees (69-83), 4-3 | Polo Grounds V (6-5) | 101-50 | |
| » Starters: Vean Gregg vs Neal Brady | First | -- |
| Thursday, November 11 |
| Future Red Sox Bill Lefebvre is born in Natick, RI. |
Game information provided by Retrosheet (www.retrosheet.org) |
