| Wednesday, March 20 |
| Future White Sox Clyde Shoun is born in Mountain City, TN. |
| Monday, April 1 |
| Future White Sox Jake Wade is born in Morehead City, NC. |
| Thursday, April 11 |
| » Defeated Browns (0-1), 6-2 | Comiskey Park I (1-0) | 1-0 | |
| » Starters: Joe Lake vs Ed Walsh | First | -- |
| » Major-league debuts: Wally Mattick and Buck Weaver (White Sox) Del Pratt (Browns) |
| Friday, April 12 |
| » Defeated Browns (0-2), 2-1 | Comiskey Park I (2-0) | 2-0 | Won 2 |
| » Starters: Jack Powell vs Jim Scott | First | -- |
| Saturday, April 13 |
| » Lost to Browns (1-2), 2-0 | Comiskey Park I (2-1) | 2-1 | |
| » Starters: Elmer Brown vs Rube Peters | Third | 1 out |
| » Major-league debuts: Jack Fournier (White Sox) |
| Sunday, April 14 |
| » Lost to Browns (2-2), 4-1 | Comiskey Park I (2-2) | 2-2 | Lost 2 |
| » Starters: George Baumgardner vs Ed Walsh | Third | 1½ out |
| » Major-league debuts: George Baumgardner (Browns) |
| Monday, April 15 |
| » Defeated Tigers (2-3), 12-7 | Comiskey Park I (3-2) | 3-2 | |
| » Starters: George Mullin vs Doc White | Third | 1 out |
| Tuesday, April 16 |
| » Lost to Tigers (3-3), 10-1 | Comiskey Park I (3-3) | 3-3 | |
| » Starters: Ed Willett vs Rube Peters | Fifth | 1½ out |
| Thursday, April 18 |
| » Defeated Browns (2-5), 12-7 | Sportsman's Park III (1-0) | 4-3 | |
| » Starters: Ed Walsh vs Red Nelson | Fourth | 1 out |
| Saturday, April 20 |
| » Tied Browns, 0-0 | Sportsman's Park III (1-0) | 4-3 | |
| » Starters: Jim Scott vs George Baumgardner | Third | 1½ out |
| Sunday, April 21 |
| » Defeated Browns (2-6), 8-3 | Sportsman's Park III (2-0) | 5-3 | Won 2 |
| » Starters: Rube Peters vs Jack Powell | Third | 1 out |
| Monday, April 22 |
| » Major-league debuts: Wheezer Dell (Cardinals) |
| Tuesday, April 23 |
| » Defeated Indians (5-4), 7-4 | League Park II (1-0) | 6-3 | Won 3 |
| » Starters: Ed Walsh vs Willie Mitchell | Second | 1 out |
| Wednesday, April 24 |
| » Defeated Indians (5-5), 6-1 | League Park II (2-0) | 7-3 | Won 4 |
| » Starters: Frank Lange vs Lefty George | First | -- |
| Thursday, April 25 |
| » Defeated Indians (5-6), 8-0 | League Park II (3-0) | 8-3 | Won 5 |
| » Starters: Joe Benz vs Gene Krapp | First | -- |
| Friday, April 26 |
| » Major-league debuts: Elmer Miller (Cardinals) |
| Saturday, April 27 |
| » Defeated Tigers (5-8), 2-0 | Tiger Stadium (1-0) | 9-3 | Won 6 |
| » Starters: Ed Walsh vs Tex Covington | First | -- |
| Sunday, April 28 |
| » Defeated Tigers (5-9), 9-5 | Tiger Stadium (2-0) | 10-3 | Won 7 |
| » Starters: Frank Lange vs Bill Burns | First | -- |
| Tuesday, April 30 |
| » Lost to Tigers (6-9), 4-3 | Tiger Stadium (2-1) | 10-4 | |
| » Starters: George Mogridge vs Ed Willett | First | -- |
| Wednesday, May 1 |
| » Defeated Tigers (6-10), 5-2 | Tiger Stadium (3-1) | 11-4 | |
| » Starters: Joe Benz vs George Mullin | First | -- |
| Thursday, May 2 |
| » Defeated Indians (7-7), 3-1 | Comiskey Park I (4-3) | 12-4 | Won 2 |
| » Starters: George Kahler vs Ed Walsh | First | -- |
| Friday, May 3 |
| » Defeated Indians (7-8), 7-4 | Comiskey Park I (5-3) | 13-4 | Won 3 |
| » Starters: Willie Mitchell vs Joe Benz | First | -- |
| Saturday, May 4 |
| » Lost to Indians (8-8), 4-3 | Comiskey Park I (5-4) | 13-5 | |
| » Starters: Fred Blanding vs Doc White | First | -- |
| Sunday, May 5 |
| » Defeated Indians (8-9), 2-1 | Comiskey Park I (6-4) | 14-5 | |
| » Starters: George Kahler vs George Mogridge | First | -- |
| Tuesday, May 7 |
| » Defeated Senators (10-7), 1-0 | Griffith Stadium (1-0) | 15-5 | Won 2 |
| » Starters: Frank Lange vs Bob Groom | First | -- |
| Wednesday, May 8 |
| » Defeated Senators (10-8), 7-6 | Griffith Stadium (2-0) | 16-5 | Won 3 |
| » Starters: Joe Benz vs Walter Johnson | First | -- |
| Thursday, May 9 |
| » Defeated Senators (10-9), 7-2 | Griffith Stadium (3-0) | 17-5 | Won 4 |
| » Starters: Joe Benz vs Dixie Walker | First | -- |
| » Major-league debuts: Howard Shanks (Senators) |
| Friday, May 10 |
| » Defeated Senators (10-10), 5-2 | Griffith Stadium (4-0) | 18-5 | Won 5 |
| » Starters: Rube Peters vs Bob Groom | First | -- |
| Saturday, May 11 |
| » Defeated Athletics (9-10), 9-5 | Shibe Park (1-0) | 19-5 | Won 6 |
| » Starters: Frank Lange vs Eddie Plank | First | -- |
| Monday, May 13 |
| » Defeated Athletics (9-11), 3-1 | Shibe Park (2-0) | 20-5 | Won 7 |
| » Starters: Ed Walsh vs Boardwalk Brown | First | -- |
| Tuesday, May 14 |
| » Defeated Athletics (9-12), 7-0 | Shibe Park (3-0) | 21-5 | Won 8 |
| » Starters: Joe Benz vs Jack Coombs | First | -- |
| Wednesday, May 15 |
| » Lost to Athletics (10-12), 8-6 | Shibe Park (3-1) | 21-6 | |
| » Starters: Frank Lange vs Byron Houck | First | -- |
| Friday, May 17 |
| » Defeated Red Sox (16-9), 5-2 | Fenway Park (1-0) | 22-6 | |
| » Starters: Ed Walsh vs Larry Pape | First | -- |
| Saturday, May 18 |
| » Defeated Red Sox (16-10), 3-1 | Fenway Park (2-0) | 23-6 | Won 2 |
| » Starters: Joe Benz vs Hugh Bedient | First | -- |
| Monday, May 20 |
| » Lost to Red Sox (17-10), 2-0 | Fenway Park (2-1) | 23-7 | |
| » Starters: Ed Walsh vs Joe Wood | First | -- |
| Tuesday, May 21 |
| » Lost to Yankees (8-17), 9-8 | Hilltop Park (0-1) | 23-8 | Lost 2 |
| » Starters: Rube Peters vs Russ Ford | First | -- |
| Future White Sox Monty Stratton is born in Celeste, TX. |
| Wednesday, May 22 |
| » Defeated Yankees (8-18), 11-5 | Hilltop Park (1-1) | 24-8 | |
| » Starters: Frank Lange vs Ray Caldwell | First | -- |
| Thursday, May 23 |
| » Defeated Yankees (8-19), 10-4 | Hilltop Park (2-1) | 25-8 | Won 2 |
| » Starters: Joe Benz vs Red Hoff | First | -- |
| Saturday, May 25 |
| » Defeated Tigers (15-18), 5-4 | Comiskey Park I (7-4) | 26-8 | Won 3 |
| » Starters: Ralph Works vs Ed Walsh | First | -- |
| Sunday, May 26 |
| » Lost to Tigers (16-18), 6-2 | Comiskey Park I (7-5) | 26-9 | |
| » Starters: George Mullin vs Joe Benz | First | -- |
| Tuesday, May 28 |
| » Defeated Indians (14-18), 7-3 | League Park II (4-0) | 27-9 | |
| » Starters: Frank Lange vs Gene Krapp | First | -- |
| Wednesday, May 29 |
| » Lost to Indians (15-18), 4-2 | League Park II (4-1) | 27-10 | |
| » Starters: Joe Benz vs George Kahler | First | -- |
| » Lost to Indians (16-18), 5-0 | League Park II (4-2) | 27-11 | Lost 2 |
| » Starters: George Mogridge vs Fred Blanding | First | -- |
| Thursday, May 30 |
| » Defeated Indians (16-19), 3-1 | League Park II (5-2) | 28-11 | |
| » Starters: Ed Walsh vs Willie Mitchell | First | -- |
| » Lost to Indians (17-19), 10-3 | League Park II (5-3) | 28-12 | |
| » Starters: Frank Lange vs Vean Gregg | First | -- |
| Saturday, June 1 |
| » Defeated Athletics (17-17), 6-3 | Comiskey Park I (8-5) | 29-12 | |
| » Starters: Chief Bender vs Joe Benz | First | -- |
| Sunday, June 2 |
| » Lost to Athletics (18-17), 3-1 | Comiskey Park I (8-6) | 29-13 | |
| » Starters: Jack Coombs vs Ed Walsh | First | -- |
| Monday, June 3 |
| » Lost to Athletics (19-17), 8-4 | Comiskey Park I (8-7) | 29-14 | Lost 2 |
| » Starters: Eddie Plank vs George Mogridge | First | -- |
| Tuesday, June 4 |
| » Defeated Athletics (19-18), 2-0 | Comiskey Park I (9-7) | 30-14 | |
| » Starters: Cy Morgan vs Frank Lange | First | -- |
| Wednesday, June 5 |
| » Lost to Senators (23-21), 8-4 | Comiskey Park I (9-8) | 30-15 | |
| » Starters: Tom Hughes vs Joe Benz | First | -- |
| Thursday, June 6 |
| » Lost to Senators (24-21), 9-1 | Comiskey Park I (9-9) | 30-16 | Lost 2 |
| » Starters: Paul Musser vs Ed Walsh | First | -- |
| » Major-league debuts: Paul Musser (Senators) |
| Friday, June 7 |
| » Lost to Senators (25-21), 4-2 | Comiskey Park I (9-10) | 30-17 | Lost 3 |
| » Starters: Bob Groom vs Frank Lange | First | -- |
| Saturday, June 8 |
| » Lost to Senators (26-21), 7-1 | Comiskey Park I (9-11) | 30-18 | Lost 4 |
| » Starters: Walter Johnson vs Doc White | First | -- |
| Sunday, June 9 |
| » Defeated Yankees (14-29), 2-1 | Comiskey Park I (10-11) | 31-18 | |
| » Starters: Ray Fisher vs George Mogridge | First | -- |
| Monday, June 10 |
| » Lost to Yankees (15-29), 5-1 | Comiskey Park I (10-12) | 31-19 | |
| » Starters: Russ Ford vs Frank Lange | Second | 1 out |
| Tuesday, June 11 |
| » Lost to Yankees (16-29), 6-3 | Comiskey Park I (10-13) | 31-20 | Lost 2 |
| » Starters: Jack Warhop vs Doc White | Second | 1 out |
| Wednesday, June 12 |
| » Defeated Yankees (16-30), 11-2 | Comiskey Park I (11-13) | 32-20 | |
| » Starters: Hippo Vaughn vs Ed Walsh | Second | 1 out |
| Thursday, June 13 |
| » Defeated Red Sox (32-19), 3-2 | Comiskey Park I (12-13) | 33-20 | Won 2 |
| » Starters: Ray Collins vs Ed Walsh | Second | 1 out |
| Saturday, June 15 |
| » Lost to Red Sox (33-19), 4-3 | Comiskey Park I (12-14) | 33-21 | |
| » Starters: Buck O'Brien vs Ed Walsh | Second | 1 out |
| Sunday, June 16 |
| » Lost to Red Sox (34-19), 6-4 | Comiskey Park I (12-15) | 33-22 | Lost 2 |
| » Starters: Joe Wood vs Frank Lange | Third | 2 out |
| Monday, June 17 |
| » Lost to Red Sox (35-19), 4-1 | Comiskey Park I (12-16) | 33-23 | Lost 3 |
| » Starters: Charley Hall vs Ed Walsh | Third | 3 out |
| Tuesday, June 18 |
| » Lost to Browns (16-37), 4-3 | Comiskey Park I (12-17) | 33-24 | Lost 4 |
| » Starters: Jack Powell vs George Mogridge | Third | 3½ out |
| Wednesday, June 19 |
| » Defeated Browns (16-38), 2-1 | Comiskey Park I (13-17) | 34-24 | |
| » Starters: Elmer Brown vs Joe Benz | Third | 3½ out |
| Friday, June 21 |
| » Defeated Browns (16-39), 8-1 | Comiskey Park I (14-17) | 35-24 | Won 2 |
| » Starters: Curly Brown vs Ed Walsh | Second | 4 out |
| Saturday, June 22 |
| » Defeated Browns (16-40), 8-1 | Comiskey Park I (15-17) | 36-24 | Won 3 |
| » Starters: Jack Powell vs Joe Benz | Second | 4½ out |
| Sunday, June 23 |
| » Lost to Indians (27-30), 2-1 | Comiskey Park I (15-18) | 36-25 | |
| » Starters: Vean Gregg vs Doc White | Second | 5 out |
| Future White Sox Gene Ford is born in Fort Dodge, IA. |
| Tuesday, June 25 |
| » Lost to Browns (17-41), 7-2 | Comiskey Park I (15-19) | 36-26 | Lost 2 |
| » Starters: Elmer Brown vs Ed Walsh | Second | 6 out |
| Wednesday, June 26 |
| » Defeated Browns (17-42), 7-0 | Comiskey Park I (16-19) | 37-26 | |
| » Starters: Mack Allison vs Joe Benz | Second | 5½ out |
| Friday, June 28 |
| » Lost to Tigers (31-35), 10-9 | Tiger Stadium (3-2) | 37-27 | |
| » Starters: Doc White vs Jean Dubuc | Third | 6½ out |
| Sunday, June 30 |
| » Defeated Tigers (31-36), 12-0 | Tiger Stadium (4-2) | 38-27 | |
| » Starters: Ed Walsh vs Tex Covington | Third | 7½ out |
| » Lost to Tigers (32-36), 11-9 | Tiger Stadium (4-3) | 38-28 | |
| » Starters: George Mogridge vs Ed Willett | Third | 7½ out |
| Tuesday, July 2 |
| » Lost to Browns (19-46), 2-1 | Sportsman's Park III (2-1) | 38-29 | Lost 2 |
| » Starters: Joe Benz vs Earl Hamilton | Third | 7½ out |
| » Defeated Browns (19-47), 5-4 | Sportsman's Park III (3-1) | 39-29 | |
| » Starters: Ed Walsh vs Elmer Brown | Third | 7½ out |
| Thursday, July 4 |
| » Defeated Indians (34-35), 2-1 | Comiskey Park I (17-19) | 40-29 | Won 2 |
| » Starters: Fred Blanding vs Rube Peters | Fourth | 8 out |
| » Lost to Indians (35-35), 9-4 | Comiskey Park I (17-20) | 40-30 | |
| » Starters: Vean Gregg vs George Mogridge | Fourth | 8 out |
| Friday, July 5 |
| » Defeated Tigers (36-38), 7-3 | Comiskey Park I (18-20) | 41-30 | |
| » Starters: Ralph Works vs Ed Walsh | Fourth | 7½ out |
| Saturday, July 6 |
| » Lost to Tigers (37-38), 4-0 | Comiskey Park I (18-21) | 41-31 | |
| » Starters: Jean Dubuc vs Joe Benz | Fourth | 8 out |
| » Defeated Tigers (37-39), 10-9 | Comiskey Park I (19-21) | 42-31 | |
| » Starters: Harry Moran vs Frank Lange | Fourth | 8 out |
| Tuesday, July 9 |
| » Lost to Athletics (42-32), 3-2 | Shibe Park (3-2) | 42-32 | |
| » Starters: Ed Walsh vs Jack Coombs | Third | 9½ out |
| Wednesday, July 10 |
| » Defeated Athletics (42-33), 4-3 | Shibe Park (4-2) | 43-32 | |
| » Starters: Rube Peters vs Eddie Plank | Third | 8½ out |
| Friday, July 12 |
| » Lost to Athletics (43-33), 2-0 | Shibe Park (4-3) | 43-33 | |
| » Starters: Joe Benz vs Chief Bender | Fourth | 10½ out |
| » Lost to Athletics (44-33), 4-1 | Shibe Park (4-4) | 43-34 | Lost 2 |
| » Starters: Ed Walsh vs Boardwalk Brown | Fourth | 10½ out |
| Saturday, July 13 |
| » Lost to Senators (50-32), 4-2 | Griffith Stadium (4-1) | 43-35 | Lost 3 |
| » Starters: Eddie Cicotte vs Walter Johnson | Fourth | 11½ out |
| Monday, July 15 |
| » Defeated Senators (50-33), 4-2 | Griffith Stadium (5-1) | 44-35 | |
| » Starters: Doc White vs Bob Groom | Fourth | 10½ out |
| Tuesday, July 16 |
| » Lost to Senators (51-33), 7-2 | Griffith Stadium (5-2) | 44-36 | |
| » Starters: Rube Peters vs Walter Johnson | Fourth | 11½ out |
| Future White Sox Milt Bocek is born in Chicago, IL. |
| Wednesday, July 17 |
| » Defeated Red Sox (57-27), 1-0 | Fenway Park (3-1) | 45-36 | |
| » Starters: Ed Walsh vs Buck O'Brien | Fourth | 11½ out |
| » Lost to Red Sox (58-27), 7-3 | Fenway Park (3-2) | 45-37 | |
| » Starters: Rube Peters vs Joe Wood | Fourth | 11½ out |
| Friday, July 19 |
| » Lost to Red Sox (59-27), 8-0 | Fenway Park (3-3) | 45-38 | Lost 2 |
| » Starters: Joe Benz vs Ray Collins | Fourth | 13½ out |
| » Lost to Red Sox (60-27), 2-1 | Fenway Park (3-4) | 45-39 | Lost 3 |
| » Starters: Eddie Cicotte vs Hugh Bedient | Fourth | 13½ out |
| Saturday, July 20 |
| » Lost to Red Sox (61-27), 3-2 | Fenway Park (3-5) | 45-40 | Lost 4 |
| » Starters: Ed Walsh vs Charley Hall | Fourth | 14½ out |
| Monday, July 22 |
| » Lost to Yankees (26-56), 13-3 | Hilltop Park (2-2) | 45-41 | Lost 5 |
| » Starters: Rube Peters vs Ray Fisher | Fourth | 15½ out |
| Tuesday, July 23 |
| » Defeated Yankees (26-57), 6-4 | Hilltop Park (3-2) | 46-41 | |
| » Starters: Joe Benz vs Russ Ford | Fourth | 15½ out |
| Wednesday, July 24 |
| » Lost to Yankees (27-57), 4-3 | Hilltop Park (3-3) | 46-42 | |
| » Starters: Ed Walsh vs George McConnell | Fourth | 15½ out |
| Future White Sox Alex Carrasquel is born in Caracas, Venezuela. |
| Thursday, July 25 |
| » Defeated Yankees (27-58), 6-4 | Hilltop Park (4-3) | 47-42 | |
| » Starters: Joe Benz vs Ray Caldwell | Fourth | 14½ out |
| Saturday, July 27 |
| » Lost to Red Sox (64-29), 5-3 | Comiskey Park I (19-22) | 47-43 | |
| » Starters: Buck O'Brien vs Ed Walsh | Fourth | 15½ out |
| Sunday, July 28 |
| » Lost to Red Sox (65-29), 5-4 | Comiskey Park I (19-23) | 47-44 | Lost 2 |
| » Starters: Joe Wood vs Eddie Cicotte | Fourth | 16½ out |
| Monday, July 29 |
| » Lost to Red Sox (66-29), 7-5 | Comiskey Park I (19-24) | 47-45 | Lost 3 |
| » Starters: Ray Collins vs Joe Benz | Fourth | 17½ out |
| Tuesday, July 30 |
| » Defeated Red Sox (66-30), 6-5 | Comiskey Park I (20-24) | 48-45 | |
| » Starters: Charley Hall vs Ed Walsh | Fourth | 16½ out |
| Wednesday, July 31 |
| » Lost to Yankees (31-61), 12-3 | Comiskey Park I (20-25) | 48-46 | |
| » Starters: Russ Ford vs Eddie Cicotte | Fourth | 17½ out |
| Thursday, August 1 |
| » Defeated Yankees (31-62), 2-1 | Comiskey Park I (21-25) | 49-46 | |
| » Starters: George McConnell vs Doc White | Fourth | 16½ out |
| Friday, August 2 |
| » Defeated Yankees (31-63), 5-3 | Comiskey Park I (22-25) | 50-46 | Won 2 |
| » Starters: Jack Warhop vs Frank Lange | Fourth | 16½ out |
| Saturday, August 3 |
| » Lost to Yankees (32-63), 2-1 | Comiskey Park I (22-26) | 50-47 | |
| » Starters: Ray Caldwell vs Joe Benz | Fourth | 16½ out |
| Sunday, August 4 |
| » Lost to Senators (63-38), 3-2 | Comiskey Park I (22-27) | 50-48 | Lost 2 |
| » Starters: Tom Hughes vs Ed Walsh | Fourth | 17½ out |
| Monday, August 5 |
| » Lost to Senators (64-38), 8-7 | Comiskey Park I (22-28) | 50-49 | Lost 3 |
| » Starters: Bob Groom vs Eddie Cicotte | Fourth | 17½ out |
| » Major-league debuts: Ernie Johnson (White Sox) |
| Tuesday, August 6 |
| » Defeated Senators (64-39), 2-1 | Comiskey Park I (23-28) | 51-49 | |
| » Starters: Bob Groom vs Doc White | Fourth | 17½ out |
| Future White Sox Bud Hafey is born in Berkeley, CA. |
| Wednesday, August 7 |
| » Lost to Senators (65-39), 10-1 | Comiskey Park I (23-29) | 51-50 | |
| » Starters: Walter Johnson vs Frank Lange | Fifth | 18 out |
| Friday, August 9 |
| » Defeated Athletics (60-43), 7-6 | Comiskey Park I (24-29) | 52-50 | |
| » Starters: Boardwalk Brown vs Ed Walsh | Fourth | 18½ out |
| Saturday, August 10 |
| » Lost to Athletics (61-43), 8-0 | Comiskey Park I (24-30) | 52-51 | |
| » Starters: Eddie Plank vs Joe Benz | Fourth | 19½ out |
| Sunday, August 11 |
| » Lost to Athletics (62-43), 9-6 | Comiskey Park I (24-31) | 52-52 | Lost 2 |
| » Starters: Chief Bender vs Doc White | Fourth | 20 out |
| » Lost to Athletics (63-43), 2-1 | Comiskey Park I (24-32) | 52-53 | Lost 3 |
| » Starters: Jack Coombs vs Roy Crabb | Fourth | 20 out |
| » Major-league debuts: Ray Schalk (White Sox) |
| Monday, August 12 |
| » Lost to Indians (51-56), 3-1 | League Park II (5-4) | 52-54 | Lost 4 |
| » Starters: Ed Walsh vs George Kahler | Fifth | 20½ out |
| Tuesday, August 13 |
| » Defeated Senators (66-43), 5-3 | Griffith Stadium (6-2) | 53-54 | |
| » Starters: Rube Peters vs Tom Hughes | Fourth | 20 out |
| Wednesday, August 14 |
| » Defeated Senators (66-44), 6-0 | Griffith Stadium (7-2) | 54-54 | Won 2 |
| » Starters: Eddie Cicotte vs Bob Groom | Fourth | 20½ out |
| Thursday, August 15 |
| » Lost to Senators (67-44), 4-3 | Griffith Stadium (7-3) | 54-55 | |
| » Starters: Doc White vs Carl Cashion | Fourth | 21½ out |
| Friday, August 16 |
| » Lost to Senators (68-44), 4-0 | Griffith Stadium (7-4) | 54-56 | Lost 2 |
| » Starters: Joe Benz vs Walter Johnson | Fourth | 21½ out |
| Saturday, August 17 |
| » Defeated Athletics (67-44), 5-4 | Shibe Park (5-4) | 55-56 | |
| » Starters: Ed Walsh vs Eddie Plank | Fourth | 21½ out |
| Tuesday, August 20 |
| » Defeated Athletics (67-45), 6-1 | Shibe Park (6-4) | 56-56 | Won 2 |
| » Starters: Eddie Cicotte vs Jack Coombs | Fourth | 21½ out |
| » Defeated Athletics (67-46), 3-2 | Shibe Park (7-4) | 57-56 | Won 3 |
| » Starters: Doc White vs Chief Bender | Fourth | 21½ out |
| Wednesday, August 21 |
| » Lost to Yankees (40-73), 6-1 | Hilltop Park (4-4) | 57-57 | |
| » Starters: Joe Benz vs Ray Caldwell | Fourth | 21½ out |
| Thursday, August 22 |
| » Defeated Yankees (40-74), 9-4 | Hilltop Park (5-4) | 58-57 | |
| » Starters: Wiley Taylor vs Jack Warhop | Fourth | 21½ out |
| Friday, August 23 |
| » Defeated Yankees (40-75), 4-2 | Hilltop Park (6-4) | 59-57 | Won 2 |
| » Starters: Eddie Cicotte vs Ray Fisher | Fourth | 21½ out |
| Saturday, August 24 |
| » Lost to Yankees (41-75), 7-6 | Hilltop Park (6-5) | 59-58 | |
| » Starters: Doc White vs Russ Ford | Fourth | 22½ out |
| Sunday, August 25 |
| » Major-league debuts: Frank Snyder (Cardinals) |
| Monday, August 26 |
| » Defeated Red Sox (82-37), 4-2 | Fenway Park (4-5) | 60-58 | |
| » Starters: Ed Walsh vs Ray Collins | Fourth | 21½ out |
| Tuesday, August 27 |
| » Tied Red Sox, 8-8 | Fenway Park (4-5) | 60-58 | |
| » Starters: Eddie Cicotte vs Hugh Bedient | Fourth | 21½ out |
| Wednesday, August 28 |
| » Lost to Red Sox (83-37), 5-3 | Fenway Park (4-6) | 60-59 | |
| » Starters: Joe Benz vs Buck O'Brien | Fourth | 23½ out |
| » Lost to Red Sox (84-37), 3-0 | Fenway Park (4-7) | 60-60 | Lost 2 |
| » Starters: Wiley Taylor vs Joe Wood | Fourth | 23½ out |
| Thursday, August 29 |
| » Major-league debuts: Wilbur Cooper (Pirates) |
| Friday, August 30 |
| » Lost to Indians (54-69), 7-2 | League Park II (5-5) | 60-61 | Lost 3 |
| » Starters: Phil Douglas vs Fred Blanding | Fourth | 25 out |
| » Major-league debuts: Ray Chapman (Indians) Phil Douglas (White Sox) |
| Saturday, August 31 |
| » Defeated Indians (54-70), 2-1 | League Park II (6-5) | 61-61 | |
| » Starters: Eddie Cicotte vs Vean Gregg | Fourth | 25 out |
| Sunday, September 1 |
| » Defeated Tigers (57-70), 7-6 | Comiskey Park I (25-32) | 62-61 | Won 2 |
| » Starters: Ed Willett vs Ed Walsh | Fourth | 24½ out |
| Monday, September 2 |
| » Lost to Tigers (58-70), 12-4 | Comiskey Park I (25-33) | 62-62 | |
| » Starters: Jean Dubuc vs Joe Benz | Fourth | 26 out |
| » Major-league debuts: Babe Borton, Mutz Ens and Polly McLarry (White Sox) |
| Tuesday, September 3 |
| » Defeated Tigers (58-71), 5-2 | Comiskey Park I (26-33) | 63-62 | |
| » Starters: George Mullin vs Eddie Cicotte | Fourth | 25½ out |
| » Tied Tigers, 6-6 | Comiskey Park I (26-33) | 63-62 | |
| » Starters: Tex Covington vs Wiley Taylor | Fourth | 25½ out |
| Wednesday, September 4 |
| » Lost to Tigers (59-71), 12-4 | Comiskey Park I (26-34) | 63-63 | |
| » Starters: Ed Willett vs Jim Scott | Fourth | 26½ out |
| Future White Sox Gordon Malzberger is born in Utopia, TX. |
| Thursday, September 5 |
| » Defeated Indians (55-73), 4-1 | Comiskey Park I (27-34) | 64-63 | |
| » Starters: Fred Blanding vs Doc White | Fourth | 26½ out |
| Friday, September 6 |
| » Lost to Indians (56-73), 5-2 | Comiskey Park I (27-35) | 64-64 | |
| » Starters: Jim Baskette vs Joe Benz | Fourth | 27½ out |
| Saturday, September 7 |
| » Lost to Indians (57-73), 3-2 | Comiskey Park I (27-36) | 64-65 | Lost 2 |
| » Starters: Bill Steen vs Eddie Cicotte | Fourth | 27½ out |
| Sunday, September 8 |
| » Lost to Indians (58-73), 5-2 | Comiskey Park I (27-37) | 64-66 | Lost 3 |
| » Starters: Willie Mitchell vs Ed Walsh | Fourth | 28 out |
| Tuesday, September 10 |
| » Lost to Red Sox (93-38), 5-4 | Comiskey Park I (27-38) | 64-67 | Lost 4 |
| » Starters: Joe Wood vs Joe Benz | Fourth | 29 out |
| Wednesday, September 11 |
| » Lost to Red Sox (94-38), 6-0 | Comiskey Park I (27-39) | 64-68 | Lost 5 |
| » Starters: Ray Collins vs Eddie Cicotte | Fourth | 30 out |
| Thursday, September 12 |
| » Lost to Red Sox (95-38), 3-1 | Comiskey Park I (27-40) | 64-69 | Lost 6 |
| » Starters: Buck O'Brien vs Frank Lange | Fourth | 31 out |
| Friday, September 13 |
| » Defeated Yankees (48-86), 2-0 | Comiskey Park I (28-40) | 65-69 | |
| » Starters: Russ Ford vs Ed Walsh | Fourth | 31 out |
| Saturday, September 14 |
| » Defeated Yankees (48-87), 4-1 | Comiskey Park I (29-40) | 66-69 | Won 2 |
| » Starters: Ray Keating vs Doc White | Fourth | 30½ out |
| Sunday, September 15 |
| » Defeated Yankees (48-88), 4-2 | Comiskey Park I (30-40) | 67-69 | Won 3 |
| » Starters: Ray Caldwell vs Eddie Cicotte | Fourth | 30 out |
| Wednesday, September 18 |
| » Defeated Athletics (82-57), 9-1 | Comiskey Park I (31-40) | 68-69 | Won 4 |
| » Starters: Stan Coveleski vs Frank Lange | Fourth | 29 out |
| » Lost to Athletics (83-57), 12-0 | Comiskey Park I (31-41) | 68-70 | |
| » Starters: Boardwalk Brown vs Doc White | Fourth | 29 out |
| Thursday, September 19 |
| » Defeated Athletics (83-58), 1-0 | Comiskey Park I (32-41) | 69-70 | |
| » Starters: Byron Houck vs Ed Walsh | Fourth | 27½ out |
| Friday, September 20 |
| » Defeated Senators (85-58), 6-1 | Comiskey Park I (33-41) | 70-70 | Won 2 |
| » Starters: Joe Engel vs Eddie Cicotte | Fourth | 26½ out |
| Sunday, September 22 |
| » Lost to Senators (86-58), 6-3 | Comiskey Park I (33-42) | 70-71 | |
| » Starters: Walter Johnson vs Jim Scott | Fourth | 28 out |
| » Lost to Senators (87-58), 4-1 | Comiskey Park I (33-43) | 70-72 | Lost 2 |
| » Starters: Bob Groom vs Frank Lange | Fourth | 28 out |
| Monday, September 23 |
| » Major-league debuts: Ted Cather (Cardinals) |
| Tuesday, September 24 |
| » Defeated Browns (48-95), 6-2 | Sportsman's Park III (4-1) | 71-72 | |
| » Starters: Ed Walsh vs Jack Powell | Fourth | 27½ out |
| » Tied Browns, 2-2 | Sportsman's Park III (4-1) | 71-72 | |
| » Starters: Joe Benz vs Earl Hamilton | Fourth | 27½ out |
| » Major-league debuts: Frank Crossin (Browns) |
| Wednesday, September 25 |
| » Lost to Browns (49-95), 5-3 | Sportsman's Park III (4-2) | 71-73 | |
| » Starters: Doc White vs George Baumgardner | Fourth | 29 out |
| » Lost to Browns (50-95), 12-0 | Sportsman's Park III (4-3) | 71-74 | Lost 2 |
| » Starters: Eddie Cicotte vs Carl Weilman | Fourth | 29 out |
| Friday, September 27 |
| » Defeated Browns (50-96), 9-5 | Sportsman's Park III (5-3) | 72-74 | |
| » Starters: Frank Lange vs Mack Allison | Fourth | 28½ out |
| » Defeated Browns (50-97), 8-2 | Sportsman's Park III (6-3) | 73-74 | Won 2 |
| » Starters: Eddie Cicotte vs Roy Mitchell | Fourth | 28½ out |
| Saturday, September 28 |
| » Lost to Browns (51-97), 5-4 | Sportsman's Park III (6-4) | 73-75 | |
| » Starters: Doc White vs Earl Hamilton | Fourth | 29 out |
| » Lost to Browns (52-97), 5-0 | Sportsman's Park III (6-5) | 73-76 | Lost 2 |
| » Starters: Frank Lange vs Carl Weilman | Fourth | 29 out |
| Sunday, September 29 |
| » Defeated Browns (52-98), 4-0 | Comiskey Park I (34-43) | 74-76 | |
| » Starters: George Baumgardner vs Ed Walsh | Fourth | 28½ out |
| Wednesday, October 2 |
| » Defeated Tigers (69-81), 8-5 | Tiger Stadium (5-3) | 75-76 | Won 2 |
| » Starters: Eddie Cicotte vs Willie Jensen | Third | 29 out |
| Friday, October 4 |
| » Defeated Tigers (69-82), 7-2 | Tiger Stadium (6-3) | 76-76 | Won 3 |
| » Starters: Ed Walsh vs George Boehler | Fourth | 28½ out |
| Saturday, October 5 |
| » Defeated Tigers (69-83), 5-0 | Tiger Stadium (7-3) | 77-76 | Won 4 |
| » Starters: Doc White vs Hooks Dauss | Fourth | |