| Thursday, March 7 |
| Former Senator Doc Amole dies in Wilmington, DE at the age of 34. |
| Monday, April 1 |
| Future Senator Jake Wade is born in Morehead City, NC. |
| Thursday, April 11 |
| » Lost to Athletics (1-0), 4-2 | Shibe Park (0-1) | 0-1 | |
| » Starters: Walter Johnson vs Jack Coombs | Second | 1 out |
| Friday, April 12 |
| » Lost to Athletics (2-0), 3-1 | Shibe Park (0-2) | 0-2 | Lost 2 |
| » Starters: Dixie Walker vs Cy Morgan | Second | 2 out |
| Future Senator Jack Wilson is born in Portland, OR. |
| Monday, April 15 |
| » Defeated Yankees (0-4), 1-0 | Hilltop Park (1-0) | 1-2 | |
| » Starters: Walter Johnson vs Jack Quinn | Fifth | 2 out |
| Tuesday, April 16 |
| » Defeated Yankees (0-5), 10-3 | Hilltop Park (2-0) | 2-2 | Won 2 |
| » Starters: Bob Groom vs Russ Ford | Fourth | 1½ out |
| Friday, April 19 |
| » Defeated Athletics (3-2), 6-0 | Griffith Stadium (1-0) | 3-2 | Won 3 |
| » Starters: Boardwalk Brown vs Walter Johnson | Third | 1 out |
| Saturday, April 20 |
| » Lost to Athletics (4-2), 6-3 | Griffith Stadium (1-1) | 3-3 | |
| » Starters: Jack Coombs vs Dixie Walker | Fourth | 2 out |
| Tuesday, April 23 |
| » Defeated Red Sox (5-2), 6-2 | Fenway Park (1-0) | 4-3 | |
| » Starters: Bob Groom vs Joe Wood | Third | 1 out |
| Wednesday, April 24 |
| » Defeated Red Sox (5-3), 5-2 | Fenway Park (2-0) | 5-3 | Won 2 |
| » Starters: Walter Johnson vs Eddie Cicotte | Second | 1 out |
| » Major-league debuts: Pinch Thomas (Red Sox) |
| Thursday, April 25 |
| » Lost to Red Sox (6-3), 4-1 | Fenway Park (2-1) | 5-4 | |
| » Starters: Tom Hughes vs Charley Hall | Third | 2 out |
| Friday, April 26 |
| » Lost to Yankees (2-8), 10-2 | Griffith Stadium (1-2) | 5-5 | Lost 2 |
| » Starters: Jack Quinn vs Dixie Walker | Fourth | 2½ out |
| Saturday, April 27 |
| » Defeated Yankees (2-9), 5-0 | Griffith Stadium (2-2) | 6-5 | |
| » Starters: Ray Caldwell vs Bob Groom | Third | 2½ out |
| Monday, April 29 |
| » Defeated Yankees (2-10), 2-0 | Griffith Stadium (3-2) | 7-5 | Won 2 |
| » Starters: Hippo Vaughn vs Walter Johnson | Third | 2½ out |
| Wednesday, May 1 |
| » Defeated Red Sox (9-5), 2-1 | Griffith Stadium (4-2) | 8-5 | Won 3 |
| » Starters: Joe Wood vs Tom Hughes | Third | 2 out |
| Thursday, May 2 |
| » Lost to Red Sox (10-5), 6-5 | Griffith Stadium (4-3) | 8-6 | |
| » Starters: Charley Hall vs Bob Groom | Third | 3 out |
| Friday, May 3 |
| » Defeated Red Sox (10-6), 5-1 | Griffith Stadium (5-3) | 9-6 | |
| » Starters: Buck O'Brien vs Walter Johnson | Third | 3 out |
| Saturday, May 4 |
| » Defeated Red Sox (10-7), 8-7 | Griffith Stadium (6-3) | 10-6 | Won 2 |
| » Starters: Hugh Bedient vs Carl Cashion | Second | 2 out |
| Tuesday, May 7 |
| » Lost to White Sox (15-5), 1-0 | Griffith Stadium (6-4) | 10-7 | |
| » Starters: Frank Lange vs Bob Groom | Third | 3½ out |
| Wednesday, May 8 |
| » Lost to White Sox (16-5), 7-6 | Griffith Stadium (6-5) | 10-8 | Lost 2 |
| » Starters: Joe Benz vs Walter Johnson | Third | 4½ out |
| Thursday, May 9 |
| » Lost to White Sox (17-5), 7-2 | Griffith Stadium (6-6) | 10-9 | Lost 3 |
| » Starters: Joe Benz vs Dixie Walker | Fourth | 5½ out |
| » Major-league debuts: Howard Shanks (Senators) |
| Friday, May 10 |
| » Lost to White Sox (18-5), 5-2 | Griffith Stadium (6-7) | 10-10 | Lost 4 |
| » Starters: Rube Peters vs Bob Groom | Fourth | 6½ out |
| Saturday, May 11 |
| » Defeated Indians (9-10), 8-0 | Griffith Stadium (7-7) | 11-10 | |
| » Starters: Willie Mitchell vs Walter Johnson | Third | 6½ out |
| Sunday, May 12 |
| » Lost to Indians (10-10), 6-1 | League Park II (0-1) | 11-11 | |
| » Starters: Jerry Akers vs George Kahler | Fourth | 7 out |
| Monday, May 13 |
| » Defeated Indians (10-11), 9-6 | Griffith Stadium (8-7) | 12-11 | |
| » Starters: Fred Blanding vs Dixie Walker | Third | 7 out |
| Tuesday, May 14 |
| » Lost to Indians (11-11), 3-2 | Griffith Stadium (8-8) | 12-12 | |
| » Starters: Vean Gregg vs Bob Groom | Fourth | 8 out |
| Friday, May 17 |
| » Defeated Browns (6-18), 6-2 | Griffith Stadium (9-8) | 13-12 | |
| » Starters: Elmer Brown vs Walter Johnson | Third | 7½ out |
| Saturday, May 18 |
| » Lost to Browns (7-18), 8-2 | Griffith Stadium (9-9) | 13-13 | |
| » Starters: Joe Lake vs Tom Hughes | Fourth | 8½ out |
| Monday, May 20 |
| » Defeated Browns (7-19), 5-4 | Griffith Stadium (10-9) | 14-13 | |
| » Starters: George Baumgardner vs Dixie Walker | Fourth | 7½ out |
| Tuesday, May 21 |
| » Lost to Tigers (15-15), 2-0 | Griffith Stadium (10-10) | 14-14 | |
| » Starters: George Mullin vs Walter Johnson | Fourth | 7½ out |
| Wednesday, May 22 |
| » Defeated Tigers (15-16), 5-4 | Griffith Stadium (11-10) | 15-14 | |
| » Starters: Ed Willett vs Bob Groom | Third | 7½ out |
| Thursday, May 23 |
| » Defeated Tigers (15-17), 5-2 | Griffith Stadium (12-10) | 16-14 | Won 2 |
| » Starters: Bill Burns vs Tom Hughes | Third | 7½ out |
| Friday, May 24 |
| » Lost to Yankees (9-19), 11-6 | Hilltop Park (2-1) | 16-15 | |
| » Starters: Dixie Walker vs Jack Quinn | Third | 8 out |
| Saturday, May 25 |
| » Lost to Yankees (10-19), 6-3 | Hilltop Park (2-2) | 16-16 | Lost 2 |
| » Starters: Walter Johnson vs Russ Ford | Third | 9½ out |
| » Lost to Yankees (11-19), 9-5 | Hilltop Park (2-3) | 16-17 | Lost 3 |
| » Starters: Bob Groom vs Hippo Vaughn | Third | 9½ out |
| Monday, May 27 |
| » Lost to Yankees (12-19), 10-5 | Hilltop Park (2-4) | 16-18 | Lost 4 |
| » Starters: Tom Hughes vs Ray Caldwell | Fourth | 9½ out |
| Tuesday, May 28 |
| » Defeated Yankees (12-20), 8-3 | Hilltop Park (3-4) | 17-18 | |
| » Starters: Walter Johnson vs Jack Quinn | Fourth | 9½ out |
| Wednesday, May 29 |
| » Lost to Red Sox (23-12), 21-8 | Fenway Park (2-2) | 17-19 | |
| » Starters: Dixie Walker vs Joe Wood | Sixth | 9½ out |
| » Lost to Red Sox (24-12), 12-11 | Fenway Park (2-3) | 17-20 | Lost 2 |
| » Starters: Bob Groom vs Eddie Cicotte | Sixth | 9½ out |
| Thursday, May 30 |
| » Lost to Red Sox (25-12), 3-2 | Fenway Park (2-4) | 17-21 | Lost 3 |
| » Starters: Joe Engel vs Hugh Bedient | Sixth | 9½ out |
| » Defeated Red Sox (25-13), 5-0 | Fenway Park (3-4) | 18-21 | |
| » Starters: Walter Johnson vs Buck O'Brien | Sixth | 9½ out |
| » Major-league debuts: Joe Engel (Senators) |
| Saturday, June 1 |
| » Defeated Browns (12-27), 8-3 | Sportsman's Park III (1-0) | 19-21 | Won 2 |
| » Starters: Tom Hughes vs Red Nelson | Sixth | 9½ out |
| Sunday, June 2 |
| » Defeated Browns (12-28), 6-3 | Sportsman's Park III (2-0) | 20-21 | Won 3 |
| » Starters: Bob Groom vs Joe Lake | Fifth | 8½ out |
| Monday, June 3 |
| » Defeated Browns (12-29), 13-4 | Sportsman's Park III (3-0) | 21-21 | Won 4 |
| » Starters: Joe Engel vs George Baumgardner | Fifth | 7½ out |
| Tuesday, June 4 |
| » Defeated Browns (12-30), 3-2 | Sportsman's Park III (4-0) | 22-21 | Won 5 |
| » Starters: Walter Johnson vs Jack Powell | Fifth | 7½ out |
| Wednesday, June 5 |
| » Defeated White Sox (30-15), 8-4 | Comiskey Park I (1-0) | 23-21 | Won 6 |
| » Starters: Tom Hughes vs Joe Benz | Fourth | 6½ out |
| Thursday, June 6 |
| » Defeated White Sox (30-16), 9-1 | Comiskey Park I (2-0) | 24-21 | Won 7 |
| » Starters: Paul Musser vs Ed Walsh | Third | 5½ out |
| » Major-league debuts: Paul Musser (Senators) |
| Friday, June 7 |
| » Defeated White Sox (30-17), 4-2 | Comiskey Park I (3-0) | 25-21 | Won 8 |
| » Starters: Bob Groom vs Frank Lange | Third | 4½ out |
| Saturday, June 8 |
| » Defeated White Sox (30-18), 7-1 | Comiskey Park I (4-0) | 26-21 | Won 9 |
| » Starters: Walter Johnson vs Doc White | Third | 3½ out |
| Sunday, June 9 |
| » Defeated Tigers (25-24), 4-3 | Tiger Stadium (1-0) | 27-21 | Won 10 |
| » Starters: Paul Musser vs Ed Willett | Third | 3½ out |
| Monday, June 10 |
| » Defeated Tigers (25-25), 7-3 | Tiger Stadium (2-0) | 28-21 | Won 11 |
| » Starters: Joe Engel vs George Mullin | Third | 2½ out |
| Tuesday, June 11 |
| » Defeated Tigers (25-26), 3-2 | Tiger Stadium (3-0) | 29-21 | Won 12 |
| » Starters: Bob Groom vs Jean Dubuc | Third | 2½ out |
| Wednesday, June 12 |
| » Defeated Tigers (25-27), 5-1 | Tiger Stadium (4-0) | 30-21 | Won 13 |
| » Starters: Walter Johnson vs Tex Covington | Third | 2½ out |
| Thursday, June 13 |
| » Defeated Indians (23-26), 6-3 | League Park II (1-1) | 31-21 | Won 14 |
| » Starters: Bob Groom vs Lefty George | Third | 1½ out |
| Friday, June 14 |
| » Defeated Indians (23-27), 13-8 | League Park II (2-1) | 32-21 | Won 15 |
| » Starters: Tom Hughes vs Fred Blanding | Third | 1 out |
| Saturday, June 15 |
| » Defeated Indians (23-28), 6-5 | League Park II (3-1) | 33-21 | Won 16 |
| » Starters: Carl Cashion vs Willie Mitchell | Second | 1 out |
| Tuesday, June 18 |
| » Defeated Athletics (28-22), 5-4 | Griffith Stadium (13-10) | 34-21 | Won 17 |
| » Starters: Cy Morgan vs Bob Groom | Second | 1½ out |
| Wednesday, June 19 |
| » Lost to Athletics (29-22), 2-1 | Shibe Park (0-3) | 34-22 | |
| » Starters: Tom Hughes vs Jack Coombs | Second | 3 out |
| » Lost to Athletics (30-22), 4-3 | Shibe Park (0-4) | 34-23 | Lost 2 |
| » Starters: Barney Pelty vs Chief Bender | Second | 3 out |
| Thursday, June 20 |
| » Lost to Athletics (31-22), 5-0 | Shibe Park (0-5) | 34-24 | Lost 3 |
| » Starters: Joe Engel vs Eddie Plank | Fourth | 4½ out |
| » Lost to Athletics (32-22), 8-1 | Shibe Park (0-6) | 34-25 | Lost 4 |
| » Starters: Carl Cashion vs Boardwalk Brown | Fourth | 4½ out |
| » Major-league debuts: Joe Boehling (Senators) |
| Friday, June 21 |
| » Defeated Athletics (32-23), 8-2 | Shibe Park (1-6) | 35-25 | |
| » Starters: Bob Groom vs Cy Morgan | Third | 4½ out |
| Saturday, June 22 |
| » Defeated Athletics (32-24), 12-4 | Shibe Park (2-6) | 36-25 | Won 2 |
| » Starters: Tom Hughes vs Jack Coombs | Third | 5 out |
| Sunday, June 23 |
| » Major-league debuts: Harry Moran (Tigers) |
| Monday, June 24 |
| » Lost to Red Sox (41-19), 3-1 | Griffith Stadium (13-11) | 36-26 | |
| » Starters: Hugh Bedient vs Barney Pelty | Third | 6 out |
| Wednesday, June 26 |
| » Defeated Red Sox (41-20), 3-2 | Griffith Stadium (14-11) | 37-26 | |
| » Starters: Buck O'Brien vs Bob Groom | Third | 6 out |
| » Lost to Red Sox (42-20), 3-0 | Griffith Stadium (14-12) | 37-27 | |
| » Starters: Joe Wood vs Walter Johnson | Third | 6 out |
| Thursday, June 27 |
| » Defeated Red Sox (42-21), 8-4 | Griffith Stadium (15-12) | 38-27 | |
| » Starters: Charley Hall vs Tom Hughes | Third | 5 out |
| Friday, June 28 |
| » Lost to Athletics (36-25), 4-3 | Griffith Stadium (15-13) | 38-28 | |
| » Starters: Chief Bender vs Hippo Vaughn | Fourth | 7 out |
| » Lost to Athletics (37-25), 5-4 | Griffith Stadium (15-14) | 38-29 | Lost 2 |
| » Starters: Cy Morgan vs Barney Pelty | Fourth | 7 out |
| Saturday, June 29 |
| » Lost to Athletics (38-25), 2-1 | Griffith Stadium (15-15) | 38-30 | Lost 3 |
| » Starters: Eddie Plank vs Walter Johnson | Fourth | 8½ out |
| Monday, July 1 |
| » Lost to Athletics (39-25), 6-2 | Griffith Stadium (15-16) | 38-31 | Lost 4 |
| » Starters: Boardwalk Brown vs Bob Groom | Fourth | 9½ out |
| Tuesday, July 2 |
| » Defeated Athletics (39-26), 5-3 | Griffith Stadium (16-16) | 39-31 | |
| » Starters: Byron Houck vs Tom Hughes | Fourth | 8½ out |
| Wednesday, July 3 |
| » Defeated Yankees (19-45), 3-2 | Griffith Stadium (17-16) | 40-31 | Won 2 |
| » Starters: Jack Warhop vs Hippo Vaughn | Fourth | 8 out |
| » Defeated Yankees (19-46), 10-2 | Griffith Stadium (18-16) | 41-31 | Won 3 |
| » Starters: Ray Fisher vs Walter Johnson | Fourth | 8 out |
| » Major-league debuts: John Dowd (Yankees) |
| Thursday, July 4 |
| » Defeated Yankees (19-47), 12-5 | Griffith Stadium (19-16) | 42-31 | Won 4 |
| » Starters: George McConnell vs Carl Cashion | Third | 7 out |
| » Defeated Yankees (19-48), 12-1 | Griffith Stadium (20-16) | 43-31 | Won 5 |
| » Starters: Jack Quinn vs Bob Groom | Third | 7 out |
| Friday, July 5 |
| » Defeated Yankees (19-49), 6-5 | Griffith Stadium (21-16) | 44-31 | Won 6 |
| » Starters: Ray Fisher vs Joe Engel | Second | 6½ out |
| Saturday, July 6 |
| » Defeated Yankees (19-50), 8-7 | Hilltop Park (4-4) | 45-31 | Won 7 |
| » Starters: Tom Hughes vs Russ Ford | Second | 6½ out |
| Tuesday, July 9 |
| » Defeated Indians (39-37), 2-1 | Griffith Stadium (22-16) | 46-31 | Won 8 |
| » Starters: Fred Blanding vs Barney Pelty | Second | 6½ out |
| » Defeated Indians (39-38), 4-3 | Griffith Stadium (23-16) | 47-31 | Won 9 |
| » Starters: George Kahler vs Walter Johnson | Second | 6½ out |
| Wednesday, July 10 |
| » Defeated Indians (39-39), 8-7 | Griffith Stadium (24-16) | 48-31 | Won 10 |
| » Starters: Jim Baskette vs Bob Groom | Second | 5½ out |
| Thursday, July 11 |
| » Lost to Indians (40-39), 9-3 | Griffith Stadium (24-17) | 48-32 | |
| » Starters: Bill Steen vs Tom Hughes | Second | 6 out |
| Friday, July 12 |
| » Defeated Indians (40-40), 2-1 | Griffith Stadium (25-17) | 49-32 | |
| » Starters: George Kahler vs Hippo Vaughn | Second | 6½ out |
| Saturday, July 13 |
| » Defeated White Sox (43-35), 4-2 | Griffith Stadium (26-17) | 50-32 | Won 2 |
| » Starters: Eddie Cicotte vs Walter Johnson | Second | 6½ out |
| Monday, July 15 |
| » Lost to White Sox (44-35), 4-2 | Griffith Stadium (26-18) | 50-33 | |
| » Starters: Doc White vs Bob Groom | Second | 6½ out |
| Tuesday, July 16 |
| » Defeated White Sox (44-36), 7-2 | Griffith Stadium (27-18) | 51-33 | |
| » Starters: Rube Peters vs Walter Johnson | Second | 6½ out |
| Wednesday, July 17 |
| » Defeated Browns (24-57), 1-0 | Griffith Stadium (28-18) | 52-33 | Won 2 |
| » Starters: Mack Allison vs Tom Hughes | Second | 6½ out |
| » Lost to Browns (25-57), 7-6 | Griffith Stadium (28-19) | 52-34 | |
| » Starters: Elmer Brown vs Hippo Vaughn | Second | 6½ out |
| Friday, July 19 |
| » Defeated Browns (25-58), 5-1 | Griffith Stadium (29-19) | 53-34 | |
| » Starters: Jack Powell vs Bob Groom | Second | 6½ out |
| » Defeated Browns (25-59), 10-1 | Griffith Stadium (30-19) | 54-34 | Won 2 |
| » Starters: Curly Brown vs Carl Cashion | Second | 6½ out |
| Saturday, July 20 |
| » Tied Browns, 3-3 | Griffith Stadium (30-19) | 54-34 | |
| » Starters: George Baumgardner vs Tom Hughes | Second | 7 out |
| Monday, July 22 |
| » Defeated Tigers (43-47), 5-3 | Griffith Stadium (31-19) | 55-34 | Won 3 |
| » Starters: Ralph Works vs Walter Johnson | Second | 7 out |
| Tuesday, July 23 |
| » Lost to Tigers (44-47), 12-7 | Griffith Stadium (31-20) | 55-35 | |
| » Starters: Ed Willett vs Hippo Vaughn | Second | 8 out |
| Wednesday, July 24 |
| Future Senator Alex Carrasquel is born in Caracas, Venezuela. |
| Thursday, July 25 |
| » Lost to Tigers (45-47), 5-4 | Griffith Stadium (31-21) | 55-36 | Lost 2 |
| » Starters: Jean Dubuc vs Tom Hughes | Second | 7 out |
| » Defeated Tigers (45-48), 7-5 | Griffith Stadium (32-21) | 56-36 | |
| » Starters: George Mullin vs Walter Johnson | Second | 7 out |
| Saturday, July 27 |
| » Defeated Indians (45-49), 4-3 | League Park II (4-1) | 57-36 | Won 2 |
| » Starters: Carl Cashion vs Fred Blanding | Second | 6½ out |
| » Defeated Indians (45-50), 9-6 | League Park II (5-1) | 58-36 | Won 3 |
| » Starters: Bob Groom vs Harry Krause | Second | 6½ out |
| Sunday, July 28 |
| » Defeated Indians (45-51), 4-1 | League Park II (6-1) | 59-36 | Won 4 |
| » Starters: Walter Johnson vs Vean Gregg | Second | 6 out |
| » Defeated Indians (45-52), 3-2 | League Park II (7-1) | 60-36 | Won 5 |
| » Starters: Hippo Vaughn vs Bill Steen | Second | 6 out |
| Wednesday, July 31 |
| » Lost to Tigers (48-50), 4-1 | Tiger Stadium (4-1) | 60-37 | |
| » Starters: Carl Cashion vs Joe Lake | Second | 7 out |
| Thursday, August 1 |
| » Defeated Tigers (48-51), 6-3 | Tiger Stadium (5-1) | 61-37 | |
| » Starters: Bob Groom vs George Mullin | Second | 6 out |
| Friday, August 2 |
| » Defeated Tigers (48-52), 4-0 | Tiger Stadium (6-1) | 62-37 | Won 2 |
| » Starters: Walter Johnson vs Ed Willett | Second | 6 out |
| Saturday, August 3 |
| » Lost to Tigers (49-52), 2-1 | Tiger Stadium (6-2) | 62-38 | |
| » Starters: Hippo Vaughn vs Jean Dubuc | Second | 6 out |
| Sunday, August 4 |
| » Defeated White Sox (50-48), 3-2 | Comiskey Park I (5-0) | 63-38 | |
| » Starters: Tom Hughes vs Ed Walsh | Second | 6 out |
| Monday, August 5 |
| » Defeated White Sox (50-49), 8-7 | Comiskey Park I (6-0) | 64-38 | Won 2 |
| » Starters: Bob Groom vs Eddie Cicotte | Second | 5 out |
| » Major-league debuts: Ernie Johnson (White Sox) |
| Tuesday, August 6 |
| » Lost to White Sox (51-49), 2-1 | Comiskey Park I (6-1) | 64-39 | |
| » Starters: Bob Groom vs Doc White | Second | 6 out |
| Wednesday, August 7 |
| » Defeated White Sox (51-50), 10-1 | Comiskey Park I (7-1) | 65-39 | |
| » Starters: Walter Johnson vs Frank Lange | Second | 5½ out |
| Thursday, August 8 |
| » Lost to Browns (33-70), 8-0 | Sportsman's Park III (4-1) | 65-40 | |
| » Starters: Hippo Vaughn vs Earl Hamilton | Second | 6½ out |
| Saturday, August 10 |
| » Lost to Browns (34-70), 3-1 | Sportsman's Park III (4-2) | 65-41 | Lost 2 |
| » Starters: Bob Groom vs Mack Allison | Second | 8½ out |
| » Lost to Browns (35-70), 2-1 | Sportsman's Park III (4-3) | 65-42 | Lost 3 |
| » Starters: Tom Hughes vs Jack Powell | Second | 8½ out |
| Sunday, August 11 |
| » Defeated Browns (35-71), 3-2 | Sportsman's Park III (5-3) | 66-42 | |
| » Starters: Walter Johnson vs Earl Hamilton | Second | 7½ out |
| Monday, August 12 |
| Future Senator Harlond Clift is born in ElReno, OK. |
| Tuesday, August 13 |
| » Lost to White Sox (53-54), 5-3 | Griffith Stadium (32-22) | 66-43 | |
| » Starters: Rube Peters vs Tom Hughes | Second | 8 out |
| Wednesday, August 14 |
| » Lost to White Sox (54-54), 6-0 | Griffith Stadium (32-23) | 66-44 | Lost 2 |
| » Starters: Eddie Cicotte vs Bob Groom | Third | 9½ out |
| Thursday, August 15 |
| » Defeated White Sox (54-55), 4-3 | Griffith Stadium (33-23) | 67-44 | |
| » Starters: Doc White vs Carl Cashion | Third | 9½ out |
| Friday, August 16 |
| » Defeated White Sox (54-56), 4-0 | Griffith Stadium (34-23) | 68-44 | Won 2 |
| » Starters: Joe Benz vs Walter Johnson | Third | 8½ out |
| Saturday, August 17 |
| » Defeated Indians (51-61), 4-1 | Griffith Stadium (35-23) | 69-44 | Won 3 |
| » Starters: George Kahler vs Bob Groom | Second | 8½ out |
| Tuesday, August 20 |
| » Defeated Indians (51-62), 4-2 | Griffith Stadium (36-23) | 70-44 | Won 4 |
| » Starters: Vean Gregg vs Lefty Schegg | Second | 8½ out |
| » Defeated Indians (51-63), 2-0 | Griffith Stadium (37-23) | 71-44 | Won 5 |
| » Starters: Vean Gregg vs Carl Cashion | Second | 8½ out |
| Wednesday, August 21 |
| » Defeated Tigers (55-63), 3-1 | Griffith Stadium (38-23) | 72-44 | Won 6 |
| » Starters: Joe Lake vs Bob Groom | Second | 7½ out |
| Thursday, August 22 |
| » Lost to Tigers (56-63), 9-6 | Griffith Stadium (38-24) | 72-45 | |
| » Starters: George Mullin vs Tom Hughes | Second | 8½ out |
| Friday, August 23 |
| » Defeated Tigers (56-64), 8-1 | Griffith Stadium (39-24) | 73-45 | |
| » Starters: Jean Dubuc vs Walter Johnson | Second | 8 out |
| » Defeated Tigers (56-65), 6-4 | Griffith Stadium (40-24) | 74-45 | Won 2 |
| » Starters: Pat McGehee vs Carl Cashion | Second | 8 out |
| Saturday, August 24 |
| » Major-league debuts: Carl Weilman (Browns) |
| Sunday, August 25 |
| » Major-league debuts: Frank Snyder (Cardinals) |
| Monday, August 26 |
| » Defeated Browns (37-82), 6-3 | Griffith Stadium (41-24) | 75-45 | Won 3 |
| » Starters: Mack Allison vs Bob Groom | Second | 8 out |
| » Lost to Browns (38-82), 4-3 | Griffith Stadium (41-25) | 75-46 | |
| » Starters: Earl Hamilton vs Tom Hughes | Second | 8 out |
| Tuesday, August 27 |
| » Lost to Browns (39-82), 9-3 | Griffith Stadium (41-26) | 75-47 | Lost 2 |
| » Starters: George Baumgardner vs Carl Cashion | Second | 8½ out |
| Wednesday, August 28 |
| » Lost to Browns (40-82), 3-2 | Griffith Stadium (41-27) | 75-48 | Lost 3 |
| » Starters: Jack Powell vs Walter Johnson | Second | 10 out |
| Thursday, August 29 |
| » Defeated Yankees (44-77), 2-1 | Griffith Stadium (42-27) | 76-48 | |
| » Starters: Ray Fisher vs Joe Engel | Second | 10 out |
| Friday, August 30 |
| » Defeated Yankees (44-78), 7-2 | Griffith Stadium (43-27) | 77-48 | Won 2 |
| » Starters: Iron Davis vs Bob Groom | Second | 10 out |
| Saturday, August 31 |
| » Lost to Yankees (45-78), 1-0 | Griffith Stadium (43-28) | 77-49 | |
| » Starters: Ray Caldwell vs Carl Cashion | Second | 11 out |
| Monday, September 2 |
| » Lost to Athletics (74-50), 3-2 | Griffith Stadium (43-29) | 77-50 | Lost 2 |
| » Starters: Eddie Plank vs Tom Hughes | Second | 13 out |
| » Lost to Athletics (75-50), 9-7 | Griffith Stadium (43-30) | 77-51 | Lost 3 |
| » Starters: Roy Crabb vs Walter Johnson | Second | 13 out |
| Tuesday, September 3 |
| » Defeated Athletics (75-51), 4-2 | Griffith Stadium (44-30) | 78-51 | |
| » Starters: Roy Crabb vs Bob Groom | Second | 12½ out |
| Wednesday, September 4 |
| » Lost to Red Sox (90-37), 6-2 | Fenway Park (3-5) | 78-52 | |
| » Starters: Joe Engel vs Ray Collins | Second | 13½ out |
| » Major-league debuts: Bert Gallia (Senators) |
| Thursday, September 5 |
| » Lost to Red Sox (91-37), 4-3 | Fenway Park (3-6) | 78-53 | Lost 2 |
| » Starters: Carl Cashion vs Buck O'Brien | Third | 14½ out |
| Friday, September 6 |
| » Lost to Red Sox (92-37), 1-0 | Fenway Park (3-7) | 78-54 | Lost 3 |
| » Starters: Walter Johnson vs Joe Wood | Third | 15½ out |
| Saturday, September 7 |
| » Defeated Red Sox (92-38), 5-1 | Fenway Park (4-7) | 79-54 | |
| » Starters: Bob Groom vs Hugh Bedient | Third | 14½ out |
| Sunday, September 8 |
| » Major-league debuts: Ollie O'Mara (Tigers) |
| Tuesday, September 10 |
| » Defeated Indians (58-74), 11-2 | League Park II (8-1) | 80-54 | Won 2 |
| » Starters: Carl Cashion vs Fred Blanding | Third | 14½ out |
| Wednesday, September 11 |
| » Lost to Indians (59-74), 3-2 | League Park II (8-2) | 80-55 | |
| » Starters: Walter Johnson vs Fred Blanding | Third | 15½ out |
| Thursday, September 12 |
| » Defeated Indians (59-75), 3-2 | League Park II (9-2) | 81-55 | |
| » Starters: Bob Groom vs Willie Mitchell | Third | 15½ out |
| Friday, September 13 |
| » Lost to Tigers (63-74), 9-8 | Tiger Stadium (6-3) | 81-56 | |
| » Starters: Joe Engel vs George Boehler | Third | 16½ out |
| » Major-league debuts: George Boehler (Tigers) |
| Saturday, September 14 |
| » Lost to Tigers (64-74), 3-2 | Tiger Stadium (6-4) | 81-57 | Lost 2 |
| » Starters: Carl Cashion vs Tex Covington | Third | 17 out |
| Sunday, September 15 |
| » Defeated Tigers (64-75), 6-3 | Tiger Stadium (7-4) | 82-57 | |
| » Starters: Walter Johnson vs Bun Troy | Third | 16½ out |
| » Major-league debuts: Bun Troy (Tigers) |
| Monday, September 16 |
| » Major-league debuts: Roy Walker (Indians) |
| Wednesday, September 18 |
| » Defeated Browns (47-90), 2-0 | Sportsman's Park III (6-3) | 83-57 | Won 2 |
| » Starters: Bob Groom vs Mack Allison | Second | 14½ out |
| » Defeated Browns (47-91), 8-2 | Sportsman's Park III (7-3) | 84-57 | Won 3 |
| » Starters: Carl Cashion vs Jack Powell | Second | 14½ out |
| » Major-league debuts: Charlie Miller (Browns) |
| Thursday, September 19 |
| » Defeated Browns (47-92), 4-2 | Sportsman's Park III (8-3) | 85-57 | Won 4 |
| » Starters: Tom Hughes vs Earl Hamilton | Second | 13 out |
| Friday, September 20 |
| » Lost to White Sox (70-70), 6-1 | Comiskey Park I (7-2) | 85-58 | |
| » Starters: Joe Engel vs Eddie Cicotte | Second | 13 out |
| Sunday, September 22 |
| » Defeated White Sox (70-71), 6-3 | Comiskey Park I (8-2) | 86-58 | |
| » Starters: Walter Johnson vs Jim Scott | Second | 12½ out |
| » Defeated White Sox (70-72), 4-1 | Comiskey Park I (9-2) | 87-58 | Won 2 |
| » Starters: Bob Groom vs Frank Lange | Second | 12½ out |
| Monday, September 23 |
| » Major-league debuts: Ted Cather (Cardinals) |
| Wednesday, September 25 |
| » Major-league debuts: Al Schulz (Yankees) |
| Thursday, September 26 |
| » Tied Athletics, 3-3 | Shibe Park (2-6) | 87-58 | |
| » Starters: Tom Hughes vs Jack Coombs | Second | 13½ out |
| Friday, September 27 |
| » Defeated Athletics (85-60), 5-4 | Shibe Park (3-6) | 88-58 | Won 3 |
| » Starters: Bob Groom vs Eddie Plank | Second | 13 out |
| Saturday, September 28 |
| » Defeated Red Sox (101-46), 3-2 | Griffith Stadium (45-30) | 89-58 | Won 4 |
| » Starters: Ray Collins vs Carl Cashion | Second | 12 out |
| Monday, September 30 |
| » Lost to Red Sox (102-46), 7-5 | Griffith Stadium (45-31) | 89-59 | |
| » Starters: Buck O'Brien vs Joe Engel | Second | 13 out |
| Tuesday, October 1 |
| » Lost to Red Sox (103-46), 12-3 | Griffith Stadium (45-32) | 89-60 | Lost 2 |
| » Starters: Hugh Bedient vs Bob Groom | Second | 14 out |
| Thursday, October 3 |
| » Defeated Yankees (49-101), 4-3 | Hilltop Park (5-4) | 90-60 | |
| » Starters: Walter Johnson vs Jack Warhop | Second | 14 out |
| Friday, October 4 |
| » Defeated Yankees (49-102), 4-2 | Hilltop Park (6-4) | 91-60 | Won 2 |
| » Starters: Bob Groom vs Russ Ford | Second | 13 out |
| Saturday, October 5 |
| » Lost to Yankees (50-102), 8-6 | Hilltop Park (6-5) | 91-61 | |
| » Starters: Tom Hughes vs Ray Keating | Second | 14 out |
| » Major-league debuts: Homer Thompson (Yankees) |
| Sunday, October 6 |
| » Major-league debuts: Harry Smith (White Sox) |
| Wednesday, October 9 |
| Future Senator Mickey Haefner is born in Lenzburg, IL. |
| Friday, October 11 |
| Future Senator Mike Guerra is born in Havana, Cuba. |
| Wednesday, November 13 |
| Future Senator Alex Kampouris is born in Sacramento, CA. |
Game information provided by Retrosheet (www.retrosheet.org) |
