| Monday, April 1 |
| Future Red Sox Jake Wade is born in Morehead City, NC. |
| Thursday, April 11 |
| » Defeated Yankees (0-1), 5-3 | Hilltop Park (1-0) | 1-0 | |
| » Starters: Joe Wood vs Ray Caldwell | First | -- |
| Friday, April 12 |
| » Defeated Yankees (0-2), 5-2 | Hilltop Park (2-0) | 2-0 | Won 2 |
| » Starters: Buck O'Brien vs Russ Ford | First | -- |
| Future Red Sox Jack Wilson is born in Portland, OR. |
| Saturday, April 13 |
| » Defeated Yankees (0-3), 8-4 | Hilltop Park (3-0) | 3-0 | Won 3 |
| » Starters: Casey Hageman vs Hippo Vaughn | First | -- |
| Monday, April 15 |
| » Lost to Athletics (3-0), 4-1 | Shibe Park (0-1) | 3-1 | |
| » Starters: Eddie Cicotte vs Eddie Plank | Second | ½ out |
| Tuesday, April 16 |
| » Defeated Athletics (3-1), 9-2 | Shibe Park (1-1) | 4-1 | |
| » Starters: Joe Wood vs Harry Krause | First | -- |
| Saturday, April 20 |
| » Defeated Yankees (0-6), 7-6 | Fenway Park (1-0) | 5-1 | Won 2 |
| » Starters: Ray Caldwell vs Buck O'Brien | First | -- |
| » Major-league debuts: Benny Kauff (Yankees) |
| Tuesday, April 23 |
| » Lost to Senators (4-3), 6-2 | Fenway Park (1-1) | 5-2 | |
| » Starters: Bob Groom vs Joe Wood | First | -- |
| Wednesday, April 24 |
| » Lost to Senators (5-3), 5-2 | Fenway Park (1-2) | 5-3 | Lost 2 |
| » Starters: Walter Johnson vs Eddie Cicotte | Second | 1 out |
| » Major-league debuts: Pinch Thomas (Red Sox) |
| Thursday, April 25 |
| » Defeated Senators (5-4), 4-1 | Fenway Park (2-2) | 6-3 | |
| » Starters: Tom Hughes vs Charley Hall | Second | 1 out |
| Friday, April 26 |
| » Defeated Athletics (6-4), 7-6 | Fenway Park (3-2) | 7-3 | Won 2 |
| » Starters: Cy Morgan vs Larry Pape | Second | ½ out |
| » Major-league debuts: Hugh Bedient and Hick Cady (Red Sox) |
| Saturday, April 27 |
| » Defeated Athletics (6-5), 6-5 | Fenway Park (4-2) | 8-3 | Won 3 |
| » Starters: Boardwalk Brown vs Joe Wood | Second | ½ out |
| Monday, April 29 |
| » Lost to Athletics (7-5), 7-1 | Fenway Park (4-3) | 8-4 | |
| » Starters: Eddie Plank vs Buck O'Brien | Second | 1½ out |
| Tuesday, April 30 |
| » Defeated Athletics (7-6), 6-1 | Fenway Park (5-3) | 9-4 | |
| » Starters: Harry Krause vs Charley Hall | Second | ½ out |
| Wednesday, May 1 |
| » Lost to Senators (8-5), 2-1 | Griffith Stadium (0-1) | 9-5 | |
| » Starters: Joe Wood vs Tom Hughes | Second | 1½ out |
| Thursday, May 2 |
| » Defeated Senators (8-6), 6-5 | Griffith Stadium (1-1) | 10-5 | |
| » Starters: Charley Hall vs Bob Groom | Second | 1½ out |
| Friday, May 3 |
| » Lost to Senators (9-6), 5-1 | Griffith Stadium (1-2) | 10-6 | |
| » Starters: Buck O'Brien vs Walter Johnson | Second | 2½ out |
| Saturday, May 4 |
| » Lost to Senators (10-6), 8-7 | Griffith Stadium (1-3) | 10-7 | Lost 2 |
| » Starters: Hugh Bedient vs Carl Cashion | Third | 2½ out |
| Tuesday, May 7 |
| » Defeated Tigers (9-12), 5-4 | Fenway Park (6-3) | 11-7 | |
| » Starters: George Mullin vs Joe Wood | Second | 3 out |
| Thursday, May 9 |
| » Defeated Tigers (9-13), 7-4 | Fenway Park (7-3) | 12-7 | Won 2 |
| » Starters: Bill Burns vs Charley Hall | Second | 3½ out |
| Friday, May 10 |
| » Lost to Tigers (10-13), 6-5 | Fenway Park (7-4) | 12-8 | |
| » Starters: Ed Willett vs Buck O'Brien | Second | 4½ out |
| Saturday, May 11 |
| » Defeated Browns (6-14), 8-1 | Fenway Park (8-4) | 13-8 | |
| » Starters: Elmer Brown vs Joe Wood | Second | 4½ out |
| Monday, May 13 |
| » Defeated Browns (6-15), 14-9 | Fenway Park (9-4) | 14-8 | Won 2 |
| » Starters: Curly Brown vs Charley Hall | Second | 4½ out |
| Tuesday, May 14 |
| » Defeated Browns (6-16), 6-5 | Fenway Park (10-4) | 15-8 | Won 3 |
| » Starters: George Baumgardner vs Eddie Cicotte | Second | 4½ out |
| Wednesday, May 15 |
| » Defeated Browns (6-17), 2-1 | Fenway Park (11-4) | 16-8 | Won 4 |
| » Starters: Barney Pelty vs Joe Wood | Second | 3½ out |
| Friday, May 17 |
| » Lost to White Sox (22-6), 5-2 | Fenway Park (11-5) | 16-9 | |
| » Starters: Ed Walsh vs Larry Pape | Second | 4½ out |
| Saturday, May 18 |
| » Lost to White Sox (23-6), 3-1 | Fenway Park (11-6) | 16-10 | Lost 2 |
| » Starters: Joe Benz vs Hugh Bedient | Second | 5½ out |
| Monday, May 20 |
| » Defeated White Sox (23-7), 2-0 | Fenway Park (12-6) | 17-10 | |
| » Starters: Ed Walsh vs Joe Wood | Second | 4½ out |
| Tuesday, May 21 |
| » Defeated Indians (13-13), 3-1 | Fenway Park (13-6) | 18-10 | Won 2 |
| » Starters: Vean Gregg vs Buck O'Brien | Second | 3½ out |
| Wednesday, May 22 |
| » Defeated Indians (13-14), 9-0 | Fenway Park (14-6) | 19-10 | Won 3 |
| » Starters: George Kahler vs Charley Hall | Second | 3½ out |
| Thursday, May 23 |
| » Defeated Indians (13-15), 6-5 | Fenway Park (15-6) | 20-10 | Won 4 |
| » Starters: Lefty George vs Eddie Cicotte | Second | 3½ out |
| Friday, May 24 |
| » Defeated Athletics (13-15), 4-3 | Fenway Park (16-6) | 21-10 | Won 5 |
| » Starters: Lefty Russell vs Hugh Bedient | Second | 3 out |
| Saturday, May 25 |
| » Lost to Athletics (14-15), 8-2 | Fenway Park (16-7) | 21-11 | |
| » Starters: Jack Coombs vs Joe Wood | Second | 4 out |
| Monday, May 27 |
| » Lost to Athletics (15-15), 12-6 | Fenway Park (16-8) | 21-12 | Lost 2 |
| » Starters: Eddie Plank vs Buck O'Brien | Second | 4 out |
| Tuesday, May 28 |
| » Defeated Athletics (15-16), 7-3 | Fenway Park (17-8) | 22-12 | |
| » Starters: Byron Houck vs Charley Hall | Second | 4 out |
| Wednesday, May 29 |
| » Defeated Senators (17-19), 21-8 | Fenway Park (18-8) | 23-12 | Won 2 |
| » Starters: Dixie Walker vs Joe Wood | Second | 2 out |
| » Defeated Senators (17-20), 12-11 | Fenway Park (19-8) | 24-12 | Won 3 |
| » Starters: Bob Groom vs Eddie Cicotte | Second | 2 out |
| Thursday, May 30 |
| » Defeated Senators (17-21), 3-2 | Fenway Park (20-8) | 25-12 | Won 4 |
| » Starters: Joe Engel vs Hugh Bedient | Second | 2 out |
| » Lost to Senators (18-21), 5-0 | Fenway Park (20-9) | 25-13 | |
| » Starters: Walter Johnson vs Buck O'Brien | Second | 2 out |
| » Major-league debuts: Joe Engel (Senators) |
| Saturday, June 1 |
| » Lost to Indians (18-19), 9-2 | League Park II (0-1) | 25-14 | Lost 2 |
| » Starters: Charley Hall vs George Kahler | Second | 3 out |
| Sunday, June 2 |
| » Defeated Indians (18-20), 5-4 | League Park II (1-1) | 26-14 | |
| » Starters: Joe Wood vs Lefty George | Second | 2 out |
| Monday, June 3 |
| » Lost to Indians (19-20), 4-3 | League Park II (1-2) | 26-15 | |
| » Starters: Buck O'Brien vs Fred Blanding | Second | 2 out |
| Tuesday, June 4 |
| » Lost to Indians (20-20), 5-1 | League Park II (1-3) | 26-16 | Lost 2 |
| » Starters: Hugh Bedient vs Vean Gregg | Second | 3 out |
| Wednesday, June 5 |
| » Lost to Tigers (24-21), 8-6 | Tiger Stadium (0-1) | 26-17 | Lost 3 |
| » Starters: Charley Hall vs Ed Willett | Second | 3 out |
| Thursday, June 6 |
| » Defeated Tigers (24-22), 5-2 | Tiger Stadium (1-1) | 27-17 | |
| » Starters: Buck O'Brien vs George Mullin | Second | 2 out |
| Friday, June 7 |
| » Lost to Tigers (25-22), 4-3 | Tiger Stadium (1-2) | 27-18 | |
| » Starters: Ray Collins vs Jean Dubuc | Second | 2 out |
| Saturday, June 8 |
| » Defeated Tigers (25-23), 8-3 | Tiger Stadium (2-2) | 28-18 | |
| » Starters: Joe Wood vs Ralph Works | Second | 1 out |
| Sunday, June 9 |
| » Defeated Browns (14-33), 9-2 | Sportsman's Park III (1-0) | 29-18 | Won 2 |
| » Starters: Hugh Bedient vs Roy Mitchell | Second | 1 out |
| Monday, June 10 |
| » Defeated Browns (14-34), 3-2 | Sportsman's Park III (2-0) | 30-18 | Won 3 |
| » Starters: Buck O'Brien vs Curly Brown | First | -- |
| Tuesday, June 11 |
| » Defeated Browns (14-35), 4-0 | Sportsman's Park III (3-0) | 31-18 | Won 4 |
| » Starters: Charley Hall vs Earl Hamilton | First | -- |
| Wednesday, June 12 |
| » Defeated Browns (14-36), 5-3 | Sportsman's Park III (4-0) | 32-18 | Won 5 |
| » Starters: Joe Wood vs Jack Powell | First | -- |
| Thursday, June 13 |
| » Lost to White Sox (33-20), 3-2 | Comiskey Park I (0-1) | 32-19 | |
| » Starters: Ray Collins vs Ed Walsh | First | -- |
| Saturday, June 15 |
| » Defeated White Sox (33-21), 4-3 | Comiskey Park I (1-1) | 33-19 | |
| » Starters: Buck O'Brien vs Ed Walsh | First | -- |
| Future Red Sox Babe Dahlgren is born in San Francisco, CA. |
| Sunday, June 16 |
| » Defeated White Sox (33-22), 6-4 | Comiskey Park I (2-1) | 34-19 | Won 2 |
| » Starters: Joe Wood vs Frank Lange | First | -- |
| Monday, June 17 |
| » Defeated White Sox (33-23), 4-1 | Comiskey Park I (3-1) | 35-19 | Won 3 |
| » Starters: Charley Hall vs Ed Walsh | First | -- |
| Wednesday, June 19 |
| » Defeated Yankees (17-32), 5-2 | Hilltop Park (4-0) | 36-19 | Won 4 |
| » Starters: Hugh Bedient vs Jack Warhop | First | -- |
| » Major-league debuts: Pat Maloney (Yankees) |
| Future Red Sox Don Gutteridge is born in Pittsburg, KS. |
| Thursday, June 20 |
| » Defeated Yankees (17-33), 15-8 | Hilltop Park (5-0) | 37-19 | Won 5 |
| » Starters: Buck O'Brien vs Russ Ford | First | -- |
| » Major-league debuts: Dutch Sterrett (Yankees) |
| Friday, June 21 |
| » Defeated Yankees (17-34), 11-3 | Hilltop Park (6-0) | 38-19 | Won 6 |
| » Starters: Joe Wood vs Jack Quinn | First | -- |
| Saturday, June 22 |
| » Defeated Yankees (17-35), 13-2 | Hilltop Park (7-0) | 39-19 | Won 7 |
| » Starters: Charley Hall vs George McConnell | First | -- |
| » Defeated Yankees (17-36), 10-3 | Hilltop Park (8-0) | 40-19 | Won 8 |
| » Starters: Ray Collins vs Jack Warhop | First | -- |
| Sunday, June 23 |
| » Major-league debuts: Harry Moran (Tigers) |
| Monday, June 24 |
| » Defeated Senators (36-26), 3-1 | Griffith Stadium (2-3) | 41-19 | Won 9 |
| » Starters: Hugh Bedient vs Barney Pelty | First | -- |
| Wednesday, June 26 |
| » Lost to Senators (37-26), 3-2 | Griffith Stadium (2-4) | 41-20 | |
| » Starters: Buck O'Brien vs Bob Groom | First | -- |
| » Defeated Senators (37-27), 3-0 | Griffith Stadium (3-4) | 42-20 | |
| » Starters: Joe Wood vs Walter Johnson | First | -- |
| Thursday, June 27 |
| » Lost to Senators (38-27), 8-4 | Griffith Stadium (3-5) | 42-21 | |
| » Starters: Charley Hall vs Tom Hughes | First | -- |
| Friday, June 28 |
| » Defeated Yankees (18-40), 5-4 | Fenway Park (21-9) | 43-21 | |
| » Starters: Russ Ford vs Hugh Bedient | First | -- |
| » Defeated Yankees (18-41), 6-4 | Fenway Park (22-9) | 44-21 | Won 2 |
| » Starters: Jack Warhop vs Ray Collins | First | -- |
| Saturday, June 29 |
| » Defeated Yankees (18-42), 13-6 | Fenway Park (23-9) | 45-21 | Won 3 |
| » Starters: Jack Quinn vs Buck O'Brien | First | -- |
| » Defeated Yankees (18-43), 6-0 | Fenway Park (24-9) | 46-21 | Won 4 |
| » Starters: Tommy Thompson vs Joe Wood | First | -- |
| Monday, July 1 |
| » Defeated Yankees (18-44), 4-1 | Fenway Park (25-9) | 47-21 | Won 5 |
| » Starters: George McConnell vs Charley Hall | First | -- |
| Tuesday, July 2 |
| » Lost to Yankees (19-44), 9-7 | Fenway Park (25-10) | 47-22 | |
| » Starters: Russ Ford vs Hugh Bedient | First | -- |
| Wednesday, July 3 |
| » Defeated Athletics (39-27), 7-2 | Shibe Park (2-1) | 48-22 | |
| » Starters: Ray Collins vs Jack Coombs | First | -- |
| Thursday, July 4 |
| » Lost to Athletics (40-27), 4-3 | Shibe Park (2-2) | 48-23 | |
| » Starters: Joe Wood vs Eddie Plank | First | -- |
| » Defeated Athletics (40-28), 6-5 | Shibe Park (3-2) | 49-23 | |
| » Starters: Hugh Bedient vs Boardwalk Brown | First | -- |
| Friday, July 5 |
| » Lost to Athletics (41-28), 3-2 | Shibe Park (3-3) | 49-24 | |
| » Starters: Buck O'Brien vs Byron Houck | First | -- |
| » Defeated Athletics (41-29), 5-3 | Shibe Park (4-3) | 50-24 | |
| » Starters: Ray Collins vs Cy Morgan | First | -- |
| Saturday, July 6 |
| » Defeated Athletics (41-30), 11-5 | Shibe Park (5-3) | 51-24 | Won 2 |
| » Starters: Eddie Cicotte vs Chief Bender | First | -- |
| Monday, July 8 |
| » Defeated Browns (20-52), 5-1 | Fenway Park (26-10) | 52-24 | Won 3 |
| » Starters: Mack Allison vs Joe Wood | First | -- |
| Tuesday, July 9 |
| » Defeated Browns (20-53), 3-2 | Fenway Park (27-10) | 53-24 | Won 4 |
| » Starters: George Baumgardner vs Buck O'Brien | First | -- |
| Wednesday, July 10 |
| » Lost to Browns (21-53), 9-2 | Fenway Park (27-11) | 53-25 | |
| » Starters: Jack Powell vs Hugh Bedient | First | -- |
| Friday, July 12 |
| » Defeated Tigers (39-40), 4-1 | Fenway Park (28-11) | 54-25 | |
| » Starters: Joe Lake vs Ray Collins | First | -- |
| » Defeated Tigers (39-41), 1-0 | Fenway Park (29-11) | 55-25 | Won 2 |
| » Starters: Ed Willett vs Joe Wood | First | -- |
| Saturday, July 13 |
| » Defeated Tigers (39-42), 4-0 | Fenway Park (30-11) | 56-25 | Won 3 |
| » Starters: George Mullin vs Buck O'Brien | First | -- |
| Monday, July 15 |
| » Lost to Tigers (40-42), 6-4 | Fenway Park (30-12) | 56-26 | |
| » Starters: Ralph Works vs Charley Hall | First | -- |
| Tuesday, July 16 |
| » Defeated Tigers (40-43), 7-2 | Fenway Park (31-12) | 57-26 | |
| » Starters: Harry Moran vs Ray Collins | First | -- |
| Wednesday, July 17 |
| » Lost to White Sox (45-36), 1-0 | Fenway Park (31-13) | 57-27 | |
| » Starters: Ed Walsh vs Buck O'Brien | First | -- |
| » Defeated White Sox (45-37), 7-3 | Fenway Park (32-13) | 58-27 | |
| » Starters: Rube Peters vs Joe Wood | First | -- |
| Friday, July 19 |
| » Defeated White Sox (45-38), 8-0 | Fenway Park (33-13) | 59-27 | Won 2 |
| » Starters: Joe Benz vs Ray Collins | First | -- |
| » Defeated White Sox (45-39), 2-1 | Fenway Park (34-13) | 60-27 | Won 3 |
| » Starters: Eddie Cicotte vs Hugh Bedient | First | -- |
| Saturday, July 20 |
| » Defeated White Sox (45-40), 3-2 | Fenway Park (35-13) | 61-27 | Won 4 |
| » Starters: Ed Walsh vs Charley Hall | First | -- |
| Monday, July 22 |
| » Defeated Indians (43-47), 8-3 | Fenway Park (36-13) | 62-27 | Won 5 |
| » Starters: Harry Krause vs Buck O'Brien | First | -- |
| Tuesday, July 23 |
| » Defeated Indians (43-48), 6-3 | Fenway Park (37-13) | 63-27 | Won 6 |
| » Starters: Fred Blanding vs Joe Wood | First | -- |
| Wednesday, July 24 |
| » Lost to Indians (44-48), 11-6 | Fenway Park (37-14) | 63-28 | |
| » Starters: Bill Steen vs Hugh Bedient | First | -- |
| Thursday, July 25 |
| » Lost to Indians (45-48), 1-0 | Fenway Park (37-15) | 63-29 | Lost 2 |
| » Starters: Vean Gregg vs Ray Collins | First | -- |
| Saturday, July 27 |
| » Defeated White Sox (47-43), 5-3 | Comiskey Park I (4-1) | 64-29 | |
| » Starters: Buck O'Brien vs Ed Walsh | First | -- |
| Sunday, July 28 |
| » Defeated White Sox (47-44), 5-4 | Comiskey Park I (5-1) | 65-29 | Won 2 |
| » Starters: Joe Wood vs Eddie Cicotte | First | -- |
| Monday, July 29 |
| » Defeated White Sox (47-45), 7-5 | Comiskey Park I (6-1) | 66-29 | Won 3 |
| » Starters: Ray Collins vs Joe Benz | First | -- |
| Tuesday, July 30 |
| » Lost to White Sox (48-45), 6-5 | Comiskey Park I (6-2) | 66-30 | |
| » Starters: Charley Hall vs Ed Walsh | First | -- |
| Wednesday, July 31 |
| » Defeated Browns (29-66), 4-1 | Sportsman's Park III (5-0) | 67-30 | |
| » Starters: Hugh Bedient vs Willie Adams | First | -- |
| Thursday, August 1 |
| » Lost to Browns (30-66), 2-1 | Sportsman's Park III (5-1) | 67-31 | |
| » Starters: Buck O'Brien vs Mack Allison | First | -- |
| Friday, August 2 |
| » Defeated Browns (30-67), 9-0 | Sportsman's Park III (6-1) | 68-31 | |
| » Starters: Joe Wood vs Earl Hamilton | First | -- |
| Saturday, August 3 |
| » Lost to Browns (31-67), 4-2 | Sportsman's Park III (6-2) | 68-32 | |
| » Starters: Charley Hall vs George Baumgardner | First | -- |
| Sunday, August 4 |
| » Defeated Indians (45-55), 8-6 | League Park II (2-3) | 69-32 | |
| » Starters: Ray Collins vs Vean Gregg | First | -- |
| Monday, August 5 |
| » Lost to Indians (46-55), 3-1 | League Park II (2-4) | 69-33 | |
| » Starters: Hugh Bedient vs Vean Gregg | First | -- |
| Tuesday, August 6 |
| » Defeated Indians (46-56), 5-4 | League Park II (3-4) | 70-33 | |
| » Starters: Joe Wood vs Fred Blanding | First | -- |
| Wednesday, August 7 |
| » Tied Indians, 4-4 | League Park II (3-4) | 70-33 | |
| » Starters: Buck O'Brien vs Willie Mitchell | First | -- |
| Thursday, August 8 |
| » Defeated Tigers (53-53), 5-0 | Tiger Stadium (3-2) | 71-33 | Won 2 |
| » Starters: Ray Collins vs Joe Lake | First | -- |
| Friday, August 9 |
| » Defeated Tigers (53-54), 6-1 | Tiger Stadium (4-2) | 72-33 | Won 3 |
| » Starters: Hugh Bedient vs George Mullin | First | -- |
| Saturday, August 10 |
| » Defeated Tigers (53-55), 4-1 | Tiger Stadium (5-2) | 73-33 | Won 4 |
| » Starters: Joe Wood vs Ed Willett | First | -- |
| Sunday, August 11 |
| » Lost to Tigers (54-55), 4-2 | Tiger Stadium (5-3) | 73-34 | |
| » Starters: Ray Collins vs Jean Dubuc | First | -- |
| Wednesday, August 14 |
| » Defeated Browns (35-72), 8-2 | Fenway Park (38-15) | 74-34 | |
| » Starters: George Baumgardner vs Buck O'Brien | First | -- |
| » Defeated Browns (35-73), 8-0 | Fenway Park (39-15) | 75-34 | Won 2 |
| » Starters: Mack Allison vs Joe Wood | First | -- |
| Thursday, August 15 |
| » Defeated Browns (35-74), 13-6 | Fenway Park (40-15) | 76-34 | Won 3 |
| » Starters: Jack Powell vs Hugh Bedient | First | -- |
| » Major-league debuts: Bill Brown (Browns) |
| Friday, August 16 |
| » Lost to Browns (36-74), 3-2 | Fenway Park (40-16) | 76-35 | |
| » Starters: Earl Hamilton vs Buck O'Brien | First | -- |
| Saturday, August 17 |
| » Defeated Tigers (55-60), 6-4 | Fenway Park (41-16) | 77-35 | |
| » Starters: George Mullin vs Ray Collins | First | -- |
| Monday, August 19 |
| » Defeated Tigers (55-61), 4-3 | Fenway Park (42-16) | 78-35 | Won 2 |
| » Starters: Ed Willett vs Hugh Bedient | First | -- |
| Tuesday, August 20 |
| » Defeated Tigers (55-62), 6-2 | Fenway Park (43-16) | 79-35 | Won 3 |
| » Starters: Jean Dubuc vs Joe Wood | First | -- |
| Wednesday, August 21 |
| » Lost to Indians (52-63), 9-4 | Fenway Park (43-17) | 79-36 | |
| » Starters: Fred Blanding vs Buck O'Brien | First | -- |
| Thursday, August 22 |
| » Defeated Indians (52-64), 9-0 | Fenway Park (44-17) | 80-36 | |
| » Starters: George Kahler vs Ray Collins | First | -- |
| Friday, August 23 |
| » Defeated Indians (52-65), 5-1 | Fenway Park (45-17) | 81-36 | Won 2 |
| » Starters: Bill Steen vs Hugh Bedient | First | -- |
| Saturday, August 24 |
| » Defeated Indians (52-66), 8-4 | Fenway Park (46-17) | 82-36 | Won 3 |
| » Starters: Vean Gregg vs Joe Wood | First | -- |
| Sunday, August 25 |
| » Major-league debuts: Frank Snyder (Cardinals) |
| Monday, August 26 |
| » Lost to White Sox (60-58), 4-2 | Fenway Park (46-18) | 82-37 | |
| » Starters: Ed Walsh vs Ray Collins | First | -- |
| Tuesday, August 27 |
| » Tied White Sox, 8-8 | Fenway Park (46-18) | 82-37 | |
| » Starters: Eddie Cicotte vs Hugh Bedient | First | -- |
| Wednesday, August 28 |
| » Defeated White Sox (60-59), 5-3 | Fenway Park (47-18) | 83-37 | |
| » Starters: Joe Benz vs Buck O'Brien | First | -- |
| » Defeated White Sox (60-60), 3-0 | Fenway Park (48-18) | 84-37 | Won 2 |
| » Starters: Wiley Taylor vs Joe Wood | First | -- |
| Thursday, August 29 |
| » Defeated Athletics (73-48), 8-1 | Fenway Park (49-18) | 85-37 | Won 3 |
| » Starters: Eddie Plank vs Ray Collins | First | -- |
| Friday, August 30 |
| » Defeated Athletics (73-49), 7-4 | Fenway Park (50-18) | 86-37 | Won 4 |
| » Starters: Jack Coombs vs Hugh Bedient | First | -- |
| Saturday, August 31 |
| » Defeated Athletics (73-50), 2-1 | Fenway Park (51-18) | 87-37 | Won 5 |
| » Starters: Jack Coombs vs Buck O'Brien | First | -- |
| Monday, September 2 |
| » Defeated Yankees (45-79), 2-1 | Hilltop Park (9-0) | 88-37 | Won 6 |
| » Starters: Hugh Bedient vs Russ Ford | First | -- |
| » Defeated Yankees (45-80), 1-0 | Hilltop Park (10-0) | 89-37 | Won 7 |
| » Starters: Joe Wood vs George McConnell | First | -- |
| Wednesday, September 4 |
| » Defeated Senators (78-52), 6-2 | Fenway Park (52-18) | 90-37 | Won 8 |
| » Starters: Joe Engel vs Ray Collins | First | -- |
| » Major-league debuts: Bert Gallia (Senators) |
| Thursday, September 5 |
| » Defeated Senators (78-53), 4-3 | Fenway Park (53-18) | 91-37 | Won 9 |
| » Starters: Carl Cashion vs Buck O'Brien | First | -- |
| Friday, September 6 |
| » Defeated Senators (78-54), 1-0 | Fenway Park (54-18) | 92-37 | Won 10 |
| » Starters: Walter Johnson vs Joe Wood | First | -- |
| Saturday, September 7 |
| » Lost to Senators (79-54), 5-1 | Fenway Park (54-19) | 92-38 | |
| » Starters: Bob Groom vs Hugh Bedient | First | -- |
| Sunday, September 8 |
| » Major-league debuts: Ollie O'Mara (Tigers) |
| Monday, September 9 |
| Future Red Sox Johnny Lazor is born in Taylor, WA. |
| Tuesday, September 10 |
| » Defeated White Sox (64-67), 5-4 | Comiskey Park I (7-2) | 93-38 | |
| » Starters: Joe Wood vs Joe Benz | First | -- |
| Wednesday, September 11 |
| » Defeated White Sox (64-68), 6-0 | Comiskey Park I (8-2) | 94-38 | Won 2 |
| » Starters: Ray Collins vs Eddie Cicotte | First | -- |
| Thursday, September 12 |
| » Defeated White Sox (64-69), 3-1 | Comiskey Park I (9-2) | 95-38 | Won 3 |
| » Starters: Buck O'Brien vs Frank Lange | First | -- |
| Friday, September 13 |
| » Defeated Browns (46-88), 6-2 | Sportsman's Park III (7-2) | 96-38 | Won 4 |
| » Starters: Hugh Bedient vs Carl Weilman | First | -- |
| Sunday, September 15 |
| » Lost to Browns (47-88), 5-4 | Sportsman's Park III (7-3) | 96-39 | |
| » Starters: Charley Hall vs George Baumgardner | First | -- |
| » Defeated Browns (47-89), 2-1 | Sportsman's Park III (8-3) | 97-39 | |
| » Starters: Joe Wood vs Earl Hamilton | First | -- |
| Monday, September 16 |
| » Major-league debuts: Roy Walker (Indians) |
| Tuesday, September 17 |
| » Lost to Indians (63-76), 4-3 | League Park II (3-5) | 97-40 | |
| » Starters: Ray Collins vs Vean Gregg | First | -- |
| » Lost to Indians (64-76), 3-2 | League Park II (3-6) | 97-41 | Lost 2 |
| » Starters: Buck O'Brien vs Fred Blanding | First | -- |
| Thursday, September 19 |
| » Lost to Indians (65-76), 9-3 | League Park II (3-7) | 97-42 | Lost 3 |
| » Starters: Charley Hall vs Bill Steen | First | -- |
| » Lost to Indians (66-76), 6-0 | League Park II (3-8) | 97-43 | Lost 4 |
| » Starters: Hugh Bedient vs Jim Baskette | First | -- |
| Friday, September 20 |
| » Lost to Tigers (68-75), 6-4 | Tiger Stadium (5-4) | 97-44 | Lost 5 |
| » Starters: Joe Wood vs Tex Covington | First | -- |
| Saturday, September 21 |
| » Defeated Tigers (68-76), 11-4 | Tiger Stadium (6-4) | 98-44 | |
| » Starters: Ray Collins vs Ed Willett | First | -- |
| Sunday, September 22 |
| » Major-league debuts: Bunny Brief (Browns) |
| Monday, September 23 |
| » Major-league debuts: Ted Cather (Cardinals) |
| Tuesday, September 24 |
| » Lost to Yankees (49-93), 5-2 | Fenway Park (54-20) | 98-45 | |
| » Starters: George McConnell vs Hugh Bedient | First | -- |
| » Defeated Yankees (49-94), 3-1 | Fenway Park (55-20) | 99-45 | |
| » Starters: Ray Caldwell vs Buck O'Brien | First | -- |
| Wednesday, September 25 |
| » Defeated Yankees (49-95), 6-0 | Fenway Park (56-20) | 100-45 | Won 2 |
| » Starters: Al Schulz vs Joe Wood | First | -- |
| » Major-league debuts: Al Schulz (Yankees) |
| Thursday, September 26 |
| » Defeated Yankees (49-96), 15-12 | Fenway Park (57-20) | 101-45 | Won 3 |
| » Starters: Ray Keating vs Ben Van Dyke | First | -- |
| Saturday, September 28 |
| » Lost to Senators (89-58), 3-2 | Griffith Stadium (3-6) | 101-46 | |
| » Starters: Ray Collins vs Carl Cashion | First | -- |
| Monday, September 30 |
| » Defeated Senators (89-59), 7-5 | Griffith Stadium (4-6) | 102-46 | |
| » Starters: Buck O'Brien vs Joe Engel | First | -- |
| Tuesday, October 1 |
| » Defeated Senators (89-60), 12-3 | Griffith Stadium (5-6) | 103-46 | Won 2 |
| » Starters: Hugh Bedient vs Bob Groom | First | -- |
| Thursday, October 3 |
| » Defeated Athletics (89-61), 17-5 | Shibe Park (6-3) | 104-46 | Won 3 |
| » Starters: Joe Wood vs Boardwalk Brown | First | -- |
| Friday, October 4 |
| » Lost to Athletics (90-61), 4-3 | Shibe Park (6-4) | 104-47 | |
| » Starters: Ray Collins vs Byron Houck | First | -- |
| Saturday, October 5 |
| » Defeated Athletics (90-62), 3-0 | Shibe Park (7-4) | 105-47 | |
| » Starters: Buck O'Brien vs Chief Bender | First | -- |
| Sunday, October 6 |
| » Major-league debuts: Harry Smith (White Sox) |
| Friday, October 11 |
| Future Red Sox Mike Guerra is born in Havana, Cuba. |
| Sunday, November 10 |
| Future Red Sox Birdie Tebbetts is born in Burlington, VT. |
| Tuesday, December 3 |
| Future Red Sox Charlie Wagner is born in Reading, PA. |
Game information provided by Retrosheet (www.retrosheet.org) |
