| Monday, April 10 |
| Future Senator Roger Wolff is born in Evansville, IL. |
| Wednesday, April 12 |
| » Defeated Red Sox (0-1), 8-5 | Griffith Stadium (1-0) | 1-0 | |
| » Starters: Joe Wood vs Dolly Gray | First | -- |
| » Major-league debuts: Tilly Walker (Senators) Rip Williams (Red Sox) |
| Thursday, April 13 |
| » Defeated Red Sox (0-2), 3-2 | Griffith Stadium (2-0) | 2-0 | Won 2 |
| » Starters: Eddie Cicotte vs Bob Groom | First | -- |
| Friday, April 14 |
| » Major-league debuts: Lefty George and Earl Hamilton (Browns) Gene Krapp (Indians) |
| Saturday, April 15 |
| » Lost to Red Sox (1-2), 6-2 | Griffith Stadium (2-1) | 2-1 | |
| » Starters: Ray Collins vs Walter Johnson | Second | 1 out |
| Sunday, April 16 |
| » Major-league debuts: Jack Lively (Tigers) |
| Monday, April 17 |
| » Lost to Yankees (4-0), 6-3 | Griffith Stadium (2-2) | 2-2 | Lost 2 |
| » Starters: Harry Ables vs Dixie Walker | Second | 2 out |
| Tuesday, April 18 |
| » Defeated Yankees (4-1), 2-0 | Griffith Stadium (3-2) | 3-2 | |
| » Starters: Hippo Vaughn vs Tom Hughes | Third | 2 out |
| Friday, April 21 |
| » Defeated Yankees (4-2), 1-0 | Hilltop Park (1-0) | 4-2 | Won 2 |
| » Starters: Bob Groom vs Russ Ford | Second | 2 out |
| » Major-league debuts: Bill Bailey (Yankees) |
| Monday, April 24 |
| » Lost to Yankees (5-2), 5-3 | Hilltop Park (1-1) | 4-3 | |
| » Starters: Walter Johnson vs Jack Quinn | Third | 3 out |
| Tuesday, April 25 |
| » Lost to Athletics (3-6), 11-2 | Shibe Park (0-1) | 4-4 | Lost 2 |
| » Starters: Tom Hughes vs Jack Coombs | Fourth | 4 out |
| Future Senator Bobby Estalella is born in Cardenas, Cuba. Future Senator Connie Marrero is born in Sagua La Grande, Cuba. |
| Wednesday, April 26 |
| » Lost to Athletics (4-6), 7-2 | Shibe Park (0-2) | 4-5 | Lost 3 |
| » Starters: Bob Groom vs Chief Bender | Fifth | 5 out |
| Thursday, April 27 |
| » Lost to Athletics (5-6), 9-6 | Shibe Park (0-3) | 4-6 | Lost 4 |
| » Starters: Bill Otey vs Cy Morgan | Sixth | 6 out |
| Friday, April 28 |
| » Defeated Athletics (5-7), 2-1 | Shibe Park (1-3) | 5-6 | |
| » Starters: Walter Johnson vs Jack Coombs | Fourth | 6 out |
| Saturday, April 29 |
| » Defeated Red Sox (6-7), 4-3 | Huntington Ave Baseball Grounds (1-0) | 6-6 | Won 2 |
| » Starters: Dolly Gray vs Joe Wood | Third | 5 out |
| Sunday, April 30 |
| » Major-league debuts: Delos Drake (Tigers) |
| Monday, May 1 |
| » Lost to Red Sox (7-7), 3-2 | Huntington Ave Baseball Grounds (1-1) | 6-7 | |
| » Starters: Bob Groom vs Ed Karger | Fourth | 6½ out |
| Tuesday, May 2 |
| » Defeated Red Sox (7-8), 3-0 | Huntington Ave Baseball Grounds (2-1) | 7-7 | |
| » Starters: Walter Johnson vs Ray Collins | Third | 6½ out |
| Wednesday, May 3 |
| » Lost to Red Sox (8-8), 6-3 | Huntington Ave Baseball Grounds (2-2) | 7-8 | |
| » Starters: Bob Groom vs Larry Pape | Fourth | 7½ out |
| Thursday, May 4 |
| » Lost to Athletics (8-8), 6-2 | Griffith Stadium (3-3) | 7-9 | Lost 2 |
| » Starters: Harry Krause vs Tom Hughes | Fifth | 8½ out |
| Friday, May 5 |
| » Lost to Athletics (9-8), 9-0 | Griffith Stadium (3-4) | 7-10 | Lost 3 |
| » Starters: Eddie Plank vs Bill Otey | Fifth | 9 out |
| Saturday, May 6 |
| » Defeated Athletics (9-9), 7-6 | Griffith Stadium (4-4) | 8-10 | |
| » Starters: Lefty Russell vs Walter Johnson | Fifth | 9 out |
| Wednesday, May 10 |
| » Lost to White Sox (10-10), 9-6 | Comiskey Park I (0-1) | 8-11 | |
| » Starters: Walter Johnson vs Ed Walsh | Fifth | 10½ out |
| Thursday, May 11 |
| » Lost to White Sox (11-10), 20-6 | Comiskey Park I (0-2) | 8-12 | Lost 2 |
| » Starters: Bob Groom vs Doc White | Fifth | 10½ out |
| Friday, May 12 |
| » Defeated White Sox (11-11), 6-5 | Comiskey Park I (1-2) | 9-12 | |
| » Starters: Dolly Gray vs Fred Olmstead | Fifth | 10½ out |
| Saturday, May 13 |
| » Defeated White Sox (11-12), 11-6 | Comiskey Park I (2-2) | 10-12 | Won 2 |
| » Starters: Dixie Walker vs Frank Lange | Fifth | 9½ out |
| Sunday, May 14 |
| » Lost to Browns (6-20), 6-2 | Sportsman's Park III (0-1) | 10-13 | |
| » Starters: Bob Groom vs Barney Pelty | Sixth | 10½ out |
| Monday, May 15 |
| » Lost to Browns (7-20), 8-0 | Sportsman's Park III (0-2) | 10-14 | Lost 2 |
| » Starters: Fred Sherry vs Jack Powell | Sixth | 11½ out |
| Tuesday, May 16 |
| » Lost to Browns (8-20), 4-0 | Sportsman's Park III (0-3) | 10-15 | Lost 3 |
| » Starters: Dolly Gray vs Joe Lake | Sixth | 12½ out |
| Wednesday, May 17 |
| » Lost to Browns (9-20), 9-2 | Sportsman's Park III (0-4) | 10-16 | Lost 4 |
| » Starters: Dixie Walker vs Barney Pelty | Seventh | 13 out |
| Thursday, May 18 |
| » Lost to Indians (13-18), 9-6 | League Park II (0-1) | 10-17 | Lost 5 |
| » Starters: Tom Hughes vs Hi West | Sixth | 14 out |
| Friday, May 19 |
| » Lost to Indians (14-18), 7-1 | League Park II (0-2) | 10-18 | Lost 6 |
| » Starters: Dolly Gray vs Spec Harkness | Seventh | 15 out |
| Saturday, May 20 |
| » Lost to Indians (15-18), 8-4 | League Park II (0-3) | 10-19 | Lost 7 |
| » Starters: Bob Groom vs Pat Paige | Seventh | 15 out |
| Sunday, May 21 |
| » Lost to Indians (16-18), 8-1 | League Park II (0-4) | 10-20 | Lost 8 |
| » Starters: Tom Hughes vs Vean Gregg | Sixth | 15 out |
| Monday, May 22 |
| » Defeated Tigers (27-8), 7-3 | Bennett Park (1-0) | 11-20 | |
| » Starters: Dixie Walker vs Ed Lafitte | Seventh | 14 out |
| Tuesday, May 23 |
| » Lost to Tigers (28-8), 9-8 | Bennett Park (1-1) | 11-21 | |
| » Starters: Dolly Gray vs George Mullin | Sixth | 15 out |
| Wednesday, May 24 |
| » Lost to Tigers (29-8), 6-5 | Bennett Park (1-2) | 11-22 | Lost 2 |
| » Starters: Bob Groom vs Ralph Works | Seventh | 16 out |
| Thursday, May 25 |
| » Defeated Tigers (29-9), 6-2 | Bennett Park (2-2) | 12-22 | |
| » Starters: Walter Johnson vs Ed Willett | Seventh | 15 out |
| Saturday, May 27 |
| » Defeated Red Sox (18-17), 9-4 | Griffith Stadium (5-4) | 13-22 | Won 2 |
| » Starters: Ray Collins vs Tom Hughes | Sixth | 15 out |
| Monday, May 29 |
| » Lost to Red Sox (19-17), 12-0 | Griffith Stadium (5-5) | 13-23 | |
| » Starters: Ed Karger vs Dixie Walker | Seventh | 15 out |
| » Lost to Red Sox (20-17), 7-6 | Griffith Stadium (5-6) | 13-24 | Lost 2 |
| » Starters: Larry Pape vs Dolly Gray | Seventh | 15 out |
| Tuesday, May 30 |
| » Lost to Red Sox (21-17), 6-5 | Griffith Stadium (5-7) | 13-25 | Lost 3 |
| » Starters: Eddie Cicotte vs Tom Hughes | Seventh | 17 out |
| » Lost to Red Sox (22-17), 5-4 | Griffith Stadium (5-8) | 13-26 | Lost 4 |
| » Starters: Joe Wood vs Walter Johnson | Seventh | 17 out |
| Wednesday, May 31 |
| » Defeated Yankees (18-21), 3-2 | Griffith Stadium (6-8) | 14-26 | |
| » Starters: Jack Warhop vs Bob Groom | Seventh | 16½ out |
| Thursday, June 1 |
| » Lost to Tigers (33-11), 8-7 | Griffith Stadium (6-9) | 14-27 | |
| » Starters: Jack Lively vs Dixie Walker | Seventh | 17½ out |
| Friday, June 2 |
| » Defeated Tigers (33-12), 14-7 | Griffith Stadium (7-9) | 15-27 | |
| » Starters: Ed Willett vs Tom Hughes | Seventh | 16½ out |
| » Major-league debuts: Clarence Mitchell (Tigers) |
| Saturday, June 3 |
| » Lost to Tigers (34-12), 7-2 | Griffith Stadium (7-10) | 15-28 | |
| » Starters: George Mullin vs Walter Johnson | Seventh | 17½ out |
| Monday, June 5 |
| » Lost to Tigers (35-12), 5-1 | Griffith Stadium (7-11) | 15-29 | Lost 2 |
| » Starters: Ed Lafitte vs Bob Groom | Seventh | 18½ out |
| Tuesday, June 6 |
| » Lost to Indians (19-27), 8-2 | Griffith Stadium (7-12) | 15-30 | Lost 3 |
| » Starters: Vean Gregg vs Tom Hughes | Seventh | 19 out |
| Wednesday, June 7 |
| » Defeated Indians (19-28), 4-0 | Griffith Stadium (8-12) | 16-30 | |
| » Starters: Fred Blanding vs Dixie Walker | Seventh | 18 out |
| Thursday, June 8 |
| » Defeated Indians (19-29), 4-2 | Griffith Stadium (9-12) | 17-30 | Won 2 |
| » Starters: Willie Mitchell vs Walter Johnson | Seventh | 18 out |
| Friday, June 9 |
| » Lost to Indians (20-29), 5-2 | Griffith Stadium (9-13) | 17-31 | |
| » Starters: Cy Young vs Bob Groom | Seventh | 18 out |
| Saturday, June 10 |
| » Lost to White Sox (23-20), 18-7 | Griffith Stadium (9-14) | 17-32 | Lost 2 |
| » Starters: Fred Olmstead vs Fred Sherry | Seventh | 18 out |
| Monday, June 12 |
| » Lost to White Sox (24-20), 4-0 | Griffith Stadium (9-15) | 17-33 | Lost 3 |
| » Starters: Doc White vs Dixie Walker | Seventh | 19 out |
| Wednesday, June 14 |
| » Defeated Browns (16-36), 13-0 | Griffith Stadium (10-15) | 18-33 | |
| » Starters: Red Nelson vs Walter Johnson | Seventh | 18 out |
| Thursday, June 15 |
| » Defeated Browns (16-37), 8-7 | Griffith Stadium (11-15) | 19-33 | Won 2 |
| » Starters: Jack Powell vs Tom Hughes | Seventh | 17 out |
| Friday, June 16 |
| » Defeated Browns (16-38), 6-0 | Griffith Stadium (12-15) | 20-33 | Won 3 |
| » Starters: Barney Pelty vs Dixie Walker | Seventh | 16½ out |
| Monday, June 19 |
| » Lost to Athletics (34-18), 6-2 | Shibe Park (1-4) | 20-34 | |
| » Starters: Walter Johnson vs Chief Bender | Seventh | 17½ out |
| Wednesday, June 21 |
| » Lost to Athletics (35-18), 2-1 | Shibe Park (1-5) | 20-35 | Lost 2 |
| » Starters: Dolly Gray vs Cy Morgan | Seventh | 19½ out |
| » Lost to Athletics (36-18), 6-1 | Shibe Park (1-6) | 20-36 | Lost 3 |
| » Starters: Bob Groom vs Jack Coombs | Seventh | 19½ out |
| Thursday, June 22 |
| » Lost to Athletics (37-18), 8-5 | Shibe Park (1-7) | 20-37 | Lost 4 |
| » Starters: Dixie Walker vs Chief Bender | Seventh | 19½ out |
| Friday, June 23 |
| » Lost to Yankees (31-24), 3-2 | Hilltop Park (1-2) | 20-38 | Lost 5 |
| » Starters: Walter Johnson vs Jack Quinn | Seventh | 20½ out |
| Saturday, June 24 |
| » Lost to Yankees (32-24), 11-6 | Hilltop Park (1-3) | 20-39 | Lost 6 |
| » Starters: Tom Hughes vs Hippo Vaughn | Seventh | 21½ out |
| » Lost to Yankees (33-24), 9-2 | Hilltop Park (1-4) | 20-40 | Lost 7 |
| » Starters: Fred Sherry vs Lew Brockett | Seventh | 21½ out |
| Monday, June 26 |
| » Lost to Yankees (34-24), 3-1 | Hilltop Park (1-5) | 20-41 | Lost 8 |
| » Starters: Bob Groom vs Ray Fisher | Seventh | 22 out |
| Tuesday, June 27 |
| » Defeated Yankees (34-25), 5-2 | Hilltop Park (2-5) | 21-41 | |
| » Starters: Walter Johnson vs Jack Quinn | Seventh | 20½ out |
| » Defeated Yankees (34-26), 6-3 | Hilltop Park (3-5) | 22-41 | Won 2 |
| » Starters: Dixie Walker vs Andy Coakley | Seventh | 20½ out |
| Wednesday, June 28 |
| » Defeated Athletics (40-21), 4-3 | Griffith Stadium (13-15) | 23-41 | Won 3 |
| » Starters: Eddie Plank vs Dolly Gray | Seventh | 21 out |
| » Lost to Athletics (41-21), 16-9 | Griffith Stadium (13-16) | 23-42 | |
| » Starters: Jack Coombs vs Tom Hughes | Seventh | 21 out |
| Thursday, June 29 |
| » Defeated Athletics (41-22), 9-7 | Griffith Stadium (14-16) | 24-42 | |
| » Starters: Cy Morgan vs Bob Groom | Seventh | 20 out |
| Friday, June 30 |
| » Lost to Athletics (42-22), 6-3 | Griffith Stadium (14-17) | 24-43 | |
| » Starters: Cy Morgan vs Dixie Walker | Seventh | 20½ out |
| Saturday, July 1 |
| » Lost to Athletics (43-22), 13-8 | Griffith Stadium (14-18) | 24-44 | Lost 2 |
| » Starters: Jack Coombs vs Walter Johnson | Seventh | 21½ out |
| Monday, July 3 |
| » Lost to Red Sox (35-32), 8-6 | Huntington Ave Baseball Grounds (2-3) | 24-45 | Lost 3 |
| » Starters: Dolly Gray vs Joe Wood | Seventh | 22½ out |
| Tuesday, July 4 |
| » Defeated Red Sox (35-33), 6-4 | Huntington Ave Baseball Grounds (3-3) | 25-45 | |
| » Starters: Dixie Walker vs Eddie Cicotte | Seventh | 23 out |
| » Lost to Red Sox (36-33), 4-3 | Huntington Ave Baseball Grounds (3-4) | 25-46 | |
| » Starters: Bob Groom vs Jack Killilay | Seventh | 23 out |
| Wednesday, July 5 |
| » Defeated Red Sox (36-34), 7-2 | Huntington Ave Baseball Grounds (4-4) | 26-46 | |
| » Starters: Walter Johnson vs Larry Pape | Seventh | 22½ out |
| Friday, July 7 |
| » Lost to Tigers (49-23), 6-3 | Bennett Park (2-3) | 26-47 | |
| » Starters: Dolly Gray vs Ed Lafitte | Seventh | 23½ out |
| Saturday, July 8 |
| » Lost to Tigers (50-23), 7-5 | Bennett Park (2-4) | 26-48 | Lost 2 |
| » Starters: Dixie Walker vs Jack Lively | Sixth | 24½ out |
| Sunday, July 9 |
| » Defeated Tigers (50-24), 7-6 | Bennett Park (3-4) | 27-48 | |
| » Starters: Walter Johnson vs Clarence Mitchell | Sixth | 23½ out |
| Monday, July 10 |
| » Lost to Tigers (51-24), 4-3 | Bennett Park (3-5) | 27-49 | |
| » Starters: Bob Groom vs Ed Willett | Sixth | 24½ out |
| Tuesday, July 11 |
| » Lost to Indians (37-42), 2-1 | League Park II (0-5) | 27-50 | Lost 2 |
| » Starters: Tom Hughes vs Cy Falkenberg | Seventh | 25½ out |
| Wednesday, July 12 |
| » Lost to Indians (38-42), 4-3 | League Park II (0-6) | 27-51 | Lost 3 |
| » Starters: Bob Groom vs Vean Gregg | Seventh | 26½ out |
| Thursday, July 13 |
| » Lost to Indians (39-42), 7-5 | League Park II (0-7) | 27-52 | Lost 4 |
| » Starters: Walter Johnson vs Gene Krapp | Seventh | 27½ out |
| Friday, July 14 |
| » Lost to Indians (40-42), 4-1 | League Park II (0-8) | 27-53 | Lost 5 |
| » Starters: Dixie Walker vs Cy Young | Seventh | 28½ out |
| Saturday, July 15 |
| » Lost to White Sox (41-37), 9-5 | Comiskey Park I (2-3) | 27-54 | Lost 6 |
| » Starters: Tom Hughes vs Jim Scott | Seventh | 29½ out |
| Sunday, July 16 |
| » Lost to White Sox (42-37), 6-5 | Comiskey Park I (2-4) | 27-55 | Lost 7 |
| » Starters: Bob Groom vs Irv Young | Seventh | 30½ out |
| Monday, July 17 |
| » Defeated White Sox (42-38), 3-0 | Comiskey Park I (3-4) | 28-55 | |
| » Starters: Walter Johnson vs Frank Lange | Seventh | 30½ out |
| Tuesday, July 18 |
| » Defeated White Sox (42-39), 7-1 | Comiskey Park I (4-4) | 29-55 | Won 2 |
| » Starters: Dixie Walker vs Doc White | Seventh | 30½ out |
| Thursday, July 20 |
| » Lost to Browns (23-60), 2-0 | Sportsman's Park III (0-5) | 29-56 | |
| » Starters: Dolly Gray vs Joe Lake | Seventh | 30½ out |
| Friday, July 21 |
| » Lost to Browns (24-60), 3-2 | Sportsman's Park III (0-6) | 29-57 | Lost 2 |
| » Starters: Tom Hughes vs Jack Powell | Seventh | 30½ out |
| Saturday, July 22 |
| » Lost to Browns (25-60), 6-4 | Sportsman's Park III (0-7) | 29-58 | Lost 3 |
| » Starters: Dixie Walker vs Earl Hamilton | Seventh | 30½ out |
| Sunday, July 23 |
| » Defeated Browns (25-61), 5-1 | Sportsman's Park III (1-7) | 30-58 | |
| » Starters: Walter Johnson vs Lefty George | Seventh | 29½ out |
| Tuesday, July 25 |
| » Lost to Tigers (60-28), 5-2 | Griffith Stadium (14-19) | 30-59 | |
| » Starters: George Mullin vs Dolly Gray | Seventh | 30½ out |
| Wednesday, July 26 |
| » Defeated Tigers (60-29), 12-5 | Griffith Stadium (15-19) | 31-59 | |
| » Starters: Ed Lafitte vs Dixie Walker | Seventh | 29½ out |
| Thursday, July 27 |
| » Lost to Tigers (61-29), 7-1 | Griffith Stadium (15-20) | 31-60 | |
| » Starters: Ed Willett vs Walter Johnson | Seventh | 30½ out |
| Friday, July 28 |
| » Defeated Indians (48-48), 6-2 | Griffith Stadium (16-20) | 32-60 | |
| » Starters: Gene Krapp vs Tom Hughes | Seventh | 29 out |
| Saturday, July 29 |
| » Defeated Indians (48-49), 7-1 | Griffith Stadium (17-20) | 33-60 | Won 2 |
| » Starters: Cy Young vs Bob Groom | Seventh | 28 out |
| Monday, July 31 |
| » Defeated Indians (48-50), 5-2 | Griffith Stadium (18-20) | 34-60 | Won 3 |
| » Starters: Bill James vs Walter Johnson | Seventh | 28 out |
| Tuesday, August 1 |
| » Defeated Indians (48-51), 1-0 | Griffith Stadium (19-20) | 35-60 | Won 4 |
| » Starters: Vean Gregg vs Tom Hughes | Seventh | 28 out |
| Wednesday, August 2 |
| » Defeated White Sox (48-46), 3-1 | Griffith Stadium (20-20) | 36-60 | Won 5 |
| » Starters: Jim Scott vs Charlie Becker | Seventh | 27 out |
| » Lost to White Sox (49-46), 4-2 | Griffith Stadium (20-21) | 36-61 | |
| » Starters: Joe Hovlik vs Bob Groom | Seventh | 27 out |
| Friday, August 4 |
| » Defeated White Sox (49-47), 1-0 | Griffith Stadium (21-21) | 37-61 | |
| » Starters: Doc White vs Walter Johnson | Seventh | 26 out |
| » Defeated White Sox (49-48), 3-2 | Griffith Stadium (22-21) | 38-61 | Won 2 |
| » Starters: Ed Walsh vs Carl Cashion | Seventh | 26 out |
| » Major-league debuts: Carl Cashion (Senators) |
| Saturday, August 5 |
| » Lost to White Sox (50-48), 8-7 | Griffith Stadium (22-22) | 38-62 | |
| » Starters: Frank Lange vs Tom Hughes | Seventh | 26 out |
| Monday, August 7 |
| » Defeated Browns (30-70), 1-0 | Griffith Stadium (23-22) | 39-62 | |
| » Starters: Barney Pelty vs Bob Groom | Seventh | 27 out |
| » Lost to Browns (31-70), 13-6 | Griffith Stadium (23-23) | 39-63 | |
| » Starters: Lefty George vs Dolly Gray | Seventh | 27 out |
| » Major-league debuts: Ray Morgan (Senators) |
| Tuesday, August 8 |
| » Defeated Browns (31-71), 10-5 | Griffith Stadium (24-23) | 40-63 | |
| » Starters: Red Nelson vs Walter Johnson | Seventh | 27 out |
| Wednesday, August 9 |
| » Defeated Browns (31-72), 5-4 | Griffith Stadium (25-23) | 41-63 | Won 2 |
| » Starters: Jack Powell vs Charlie Becker | Seventh | 27 out |
| Thursday, August 10 |
| » Defeated Browns (31-73), 9-8 | Griffith Stadium (26-23) | 42-63 | Won 3 |
| » Starters: Joe Lake vs Bob Groom | Sixth | 26 out |
| Future Senator Taffy Wright is born in Tabor City, NC. |
| Friday, August 11 |
| » Defeated Yankees (54-52), 3-1 | Griffith Stadium (27-23) | 43-63 | Won 4 |
| » Starters: Jack Quinn vs Walter Johnson | Seventh | 25 out |
| » Defeated Yankees (54-53), 3-2 | Griffith Stadium (28-23) | 44-63 | Won 5 |
| » Starters: Ray Caldwell vs Tom Hughes | Seventh | 25 out |
| Saturday, August 12 |
| » Lost to Yankees (55-53), 4-0 | Griffith Stadium (28-24) | 44-64 | |
| » Starters: Ray Fisher vs Carl Cashion | Sixth | 26 out |
| Monday, August 14 |
| » Defeated Yankees (55-54), 3-0 | Griffith Stadium (29-24) | 45-64 | |
| » Starters: Jack Warhop vs Charlie Becker | Seventh | 25 out |
| Tuesday, August 15 |
| » Lost to Yankees (56-54), 6-1 | Griffith Stadium (29-25) | 45-65 | |
| » Starters: Jack Quinn vs Bob Groom | Seventh | 25½ out |
| Thursday, August 17 |
| » Defeated Browns (33-76), 5-0 | Sportsman's Park III (2-7) | 46-65 | |
| » Starters: Walter Johnson vs Red Nelson | Seventh | 26 out |
| Friday, August 18 |
| » Defeated Browns (33-77), 3-2 | Sportsman's Park III (3-7) | 47-65 | Won 2 |
| » Starters: Tom Hughes vs Barney Pelty | Seventh | 25 out |
| Saturday, August 19 |
| » Defeated Browns (33-78), 8-7 | Sportsman's Park III (4-7) | 48-65 | Won 3 |
| » Starters: Dixie Walker vs Jack Powell | Sixth | 25 out |
| Sunday, August 20 |
| » Lost to White Sox (56-57), 11-0 | Comiskey Park I (4-5) | 48-66 | |
| » Starters: Charlie Becker vs Ed Walsh | Seventh | 26 out |
| Monday, August 21 |
| » Defeated White Sox (56-58), 7-4 | Comiskey Park I (5-5) | 49-66 | |
| » Starters: Walter Johnson vs Jim Scott | Seventh | 25½ out |
| Tuesday, August 22 |
| » Lost to White Sox (57-58), 3-1 | Comiskey Park I (5-6) | 49-67 | |
| » Starters: Tom Hughes vs Doc White | Seventh | 26 out |
| Friday, August 25 |
| » Defeated Tigers (70-47), 16-2 | Bennett Park (4-5) | 50-67 | |
| » Starters: Walter Johnson vs George Mullin | Seventh | 26 out |
| » Lost to Tigers (71-47), 7-6 | Bennett Park (4-6) | 50-68 | |
| » Starters: Carl Cashion vs Ed Willett | Seventh | 26 out |
| Saturday, August 26 |
| » Lost to Tigers (72-47), 11-6 | Bennett Park (4-7) | 50-69 | Lost 2 |
| » Starters: Bob Groom vs Jack Lively | Seventh | 27½ out |
| Sunday, August 27 |
| » Lost to Indians (59-59), 1-0 | League Park II (0-9) | 50-70 | Lost 3 |
| » Starters: Carl Cashion vs Vean Gregg | Seventh | 27½ out |
| Tuesday, August 29 |
| » Defeated Indians (59-60), 2-1 | League Park II (1-9) | 51-70 | |
| » Starters: Walter Johnson vs George Kahler | Seventh | 27 out |
| Wednesday, August 30 |
| » Lost to Indians (60-60), 4-3 | League Park II (1-10) | 51-71 | |
| » Starters: Dixie Walker vs Fred Blanding | Seventh | 27½ out |
| Friday, September 1 |
| » Lost to Yankees (64-59), 6-0 | Hilltop Park (3-6) | 51-72 | Lost 2 |
| » Starters: Bob Groom vs Ray Caldwell | Seventh | 29 out |
| Saturday, September 2 |
| » Defeated Yankees (64-60), 11-1 | Hilltop Park (4-6) | 52-72 | |
| » Starters: Walter Johnson vs Jack Quinn | Seventh | 28 out |
| Monday, September 4 |
| » Lost to Athletics (80-43), 8-3 | Shibe Park (1-8) | 52-73 | |
| » Starters: Dolly Gray vs Jack Coombs | Sixth | 28 out |
| » Defeated Athletics (80-44), 6-5 | Shibe Park (2-8) | 53-73 | |
| » Starters: Dixie Walker vs Cy Morgan | Sixth | 28 out |
| Tuesday, September 5 |
| » Lost to Athletics (81-44), 10-4 | Shibe Park (2-9) | 53-74 | |
| » Starters: Carl Cashion vs Harry Krause | Seventh | 29 out |
| Wednesday, September 6 |
| » Defeated Yankees (67-61), 6-2 | Hilltop Park (5-6) | 54-74 | |
| » Starters: Bob Groom vs Ray Fisher | Seventh | 29½ out |
| » Major-league debuts: Chet Hoff (Yankees) |
| Thursday, September 7 |
| » Lost to Yankees (68-61), 5-2 | Griffith Stadium (29-26) | 54-75 | |
| » Starters: Jack Warhop vs Walter Johnson | Seventh | 30½ out |
| Friday, September 8 |
| » Lost to Yankees (69-61), 2-1 | Griffith Stadium (29-27) | 54-76 | Lost 2 |
| » Starters: Ray Caldwell vs Tom Hughes | Seventh | 31½ out |
| Saturday, September 9 |
| » Lost to Yankees (70-61), 5-1 | Griffith Stadium (29-28) | 54-77 | Lost 3 |
| » Starters: Russ Ford vs Dixie Walker | Seventh | 31½ out |
| Monday, September 11 |
| » Defeated Red Sox (64-68), 7-1 | Griffith Stadium (30-28) | 55-77 | |
| » Starters: Jack Bushelman vs Walter Johnson | Seventh | 31½ out |
| » Major-league debuts: Tommy Long (Senators) |
| Tuesday, September 12 |
| » Lost to Red Sox (65-68), 6-5 | Griffith Stadium (30-29) | 55-78 | |
| » Starters: Eddie Cicotte vs Bob Groom | Seventh | 32½ out |
| Wednesday, September 13 |
| » Defeated Red Sox (65-69), 3-1 | Griffith Stadium (31-29) | 56-78 | |
| » Starters: Larry Pape vs Tom Hughes | Seventh | 32½ out |
| Saturday, September 16 |
| » Defeated Browns (39-96), 5-4 | Griffith Stadium (32-29) | 57-78 | Won 2 |
| » Starters: Curly Brown vs Dixie Walker | Seventh | 32½ out |
| » Lost to Browns (40-96), 6-0 | Griffith Stadium (32-30) | 57-79 | |
| » Starters: Elmer Brown vs Charlie Becker | Seventh | 32½ out |
| » Major-league debuts: Elmer Brown (Browns) |
| Monday, September 18 |
| » Defeated Browns (40-97), 6-1 | Griffith Stadium (33-30) | 58-79 | |
| » Starters: Ed Hawk vs Walter Johnson | Seventh | 32½ out |
| Tuesday, September 19 |
| » Defeated White Sox (66-70), 7-3 | Griffith Stadium (34-30) | 59-79 | Won 2 |
| » Starters: Doc White vs Bob Groom | Seventh | 32½ out |
| Wednesday, September 20 |
| » Lost to White Sox (67-70), 5-3 | Griffith Stadium (34-31) | 59-80 | |
| » Starters: Joe Benz vs Tom Hughes | Seventh | 33½ out |
| Friday, September 22 |
| » Lost to White Sox (68-70), 5-0 | Griffith Stadium (34-32) | 59-81 | Lost 2 |
| » Starters: Jim Scott vs Dixie Walker | Seventh | 35½ out |
| » Lost to White Sox (69-70), 1-0 | Griffith Stadium (34-33) | 59-82 | Lost 3 |
| » Starters: Frank Lange vs Carl Cashion | Seventh | 35½ out |
| Saturday, September 23 |
| » Lost to Indians (74-66), 6-1 | Griffith Stadium (34-34) | 59-83 | Lost 4 |
| » Starters: Gene Krapp vs Walter Johnson | Seventh | 36½ out |
| Monday, September 25 |
| » Lost to Indians (75-67), 3-2 | Griffith Stadium (34-35) | 59-84 | Lost 5 |
| » Starters: Fred Blanding vs Tom Hughes | Seventh | 37 out |
| Tuesday, September 26 |
| » Defeated Indians (75-68), 8-2 | Griffith Stadium (35-35) | 60-84 | |
| » Starters: Willie Mitchell vs Bob Groom | Seventh | 37 out |
| Wednesday, September 27 |
| » Lost to Tigers (86-58), 7-5 | Griffith Stadium (35-36) | 60-85 | |
| » Starters: Tex Covington vs Carl Cashion | Seventh | 37 out |
| Thursday, September 28 |
| » Defeated Tigers (86-59), 2-1 | Griffith Stadium (36-36) | 61-85 | |
| » Starters: Ed Summers vs Walter Johnson | Seventh | 37 out |
| Friday, September 29 |
| » Lost to Tigers (87-59), 9-5 | Griffith Stadium (36-37) | 61-86 | |
| » Starters: Bill Donovan vs Tom Hughes | Seventh | 37½ out |
| Saturday, September 30 |
| » Defeated Tigers (87-60), 3-2 | Griffith Stadium (37-37) | 62-86 | |
| » Starters: Ralph Works vs Bob Groom | Seventh | 37 out |
| Tuesday, October 3 |
| » Lost to Athletics (99-48), 6-2 | Griffith Stadium (37-38) | 62-87 | |
| » Starters: Chief Bender vs Carl Cashion | Seventh | 37 out |
| » Defeated Athletics (99-49), 2-0 | Griffith Stadium (38-38) | 63-87 | |
| » Starters: Eddie Plank vs Walter Johnson | Seventh | 37 out |
| Wednesday, October 4 |
| » Defeated Athletics (99-50), 4-2 | Griffith Stadium (39-38) | 64-87 | Won 2 |
| » Starters: Harry Krause vs Bob Groom | Seventh | 36 out |
| Thursday, October 5 |
| » Lost to Red Sox (76-75), 11-2 | Huntington Ave Baseball Grounds (4-5) | 64-88 | |
| » Starters: Tom Hughes vs Ray Collins | Sixth | 37 out |
| Friday, October 6 |
| » Lost to Red Sox (77-75), 3-1 | Huntington Ave Baseball Grounds (4-6) | 64-89 | Lost 2 |
| » Starters: Walter Johnson vs Buck O'Brien | Seventh | 38 out |
| Saturday, October 7 |
| » Lost to Red Sox (78-75), 8-1 | Huntington Ave Baseball Grounds (4-7) | 64-90 | Lost 3 |
| » Starters: Carl Cashion vs Charley Hall | Seventh | 38½ out |
| Monday, October 9 |
| » Major-league debuts: John Quinn (Phillies) |
| Thursday, November 9 |
| Future Senator Ed Linke is born in Chicago, IL. |
Game information provided by Retrosheet (www.retrosheet.org) |