| Saturday, January 22 |
| Former Senator Sam Wise dies in Akron, OH at the age of 53. |
| Tuesday, February 8 |
| Former Senator Cy Vorhees dies in Perry, OH at the age of 36. |
| Monday, February 14 |
| Future Senator Alex Sabo is born in New Brunswick, NJ. |
| Sunday, March 27 |
| Future Senator Steve Sundra is born in Luxor, PA. |
| Tuesday, March 29 |
| Future Senator Bill Dietrich is born in Philadelphia, PA. |
| Monday, April 4 |
| Future Senator Joe Vosmik is born in Cleveland, OH. |
| Thursday, April 14 |
| » Defeated Athletics (0-1), 3-0 | American League Park II (1-0) | 1-0 | |
| » Starters: Eddie Plank vs Walter Johnson | First | -- |
| Friday, April 15 |
| » Lost to Athletics (1-1), 8-2 | American League Park II (1-1) | 1-1 | |
| » Starters: Chief Bender vs Doc Reisling | Third | 1 out |
| Saturday, April 16 |
| » Defeated Athletics (1-2), 4-3 | American League Park II (2-1) | 2-1 | |
| » Starters: Jack Coombs vs Dixie Walker | First | -- |
| Tuesday, April 19 |
| » Lost to Red Sox (2-1), 2-1 | Huntington Ave Baseball Grounds (0-1) | 2-2 | |
| » Starters: Frank Oberlin vs Eddie Cicotte | Fourth | 1½ out |
| » Lost to Red Sox (3-1), 5-4 | Huntington Ave Baseball Grounds (0-2) | 2-3 | Lost 2 |
| » Starters: Walter Johnson vs Joe Wood | Fourth | 1½ out |
| Wednesday, April 20 |
| » Defeated Red Sox (3-2), 12-4 | Huntington Ave Baseball Grounds (1-2) | 3-3 | |
| » Starters: Dolly Gray vs Charlie Smith | Fourth | 1½ out |
| Thursday, April 21 |
| » Lost to Red Sox (4-2), 10-3 | Huntington Ave Baseball Grounds (1-3) | 3-4 | |
| » Starters: Dixie Walker vs Ed Karger | Fourth | 1½ out |
| Friday, April 22 |
| » Lost to Yankees (3-2), 3-1 | American League Park II (2-2) | 3-5 | Lost 2 |
| » Starters: Jack Quinn vs Walter Johnson | Sixth | 2 out |
| Saturday, April 23 |
| » Tied Yankees, 0-0 | American League Park II (2-2) | 3-5 | |
| » Starters: Hippo Vaughn vs Dixie Walker | Sixth | 2½ out |
| Sunday, April 24 |
| » Major-league debuts: Rube Geyer (Cardinals) |
| Monday, April 25 |
| » Lost to Yankees (4-2), 5-2 | American League Park II (2-3) | 3-6 | Lost 3 |
| » Starters: Jack Warhop vs Frank Oberlin | Sixth | 2½ out |
| Tuesday, April 26 |
| » Defeated Yankees (4-3), 9-7 | American League Park II (3-3) | 4-6 | |
| » Starters: Rube Manning vs Dixie Walker | Fifth | 2 out |
| Wednesday, April 27 |
| » Lost to Red Sox (5-5), 11-1 | American League Park II (3-4) | 4-7 | |
| » Starters: Frank Arellanes vs Dolly Gray | Sixth | 3 out |
| Thursday, April 28 |
| » Defeated Red Sox (5-6), 2-1 | American League Park II (4-4) | 5-7 | |
| » Starters: Ray Collins vs Walter Johnson | Seventh | 3 out |
| Friday, April 29 |
| » Lost to Red Sox (6-6), 9-3 | American League Park II (4-5) | 5-8 | |
| » Starters: Charley Hall vs Frank Oberlin | Sixth | 4 out |
| Saturday, April 30 |
| » Lost to Red Sox (7-6), 5-3 | American League Park II (4-6) | 5-9 | Lost 2 |
| » Starters: Ed Karger vs Dixie Walker | Seventh | 4 out |
| Monday, May 2 |
| » Lost to Yankees (6-4), 3-2 | Hilltop Park (0-1) | 5-10 | Lost 3 |
| » Starters: Walter Johnson vs Hippo Vaughn | Seventh | 4 out |
| Tuesday, May 3 |
| » Defeated Yankees (6-5), 8-3 | Hilltop Park (1-1) | 6-10 | |
| » Starters: Bob Groom vs Slow Joe Doyle | Seventh | 4 out |
| Wednesday, May 4 |
| » Lost to Yankees (7-5), 4-2 | Hilltop Park (1-2) | 6-11 | |
| » Starters: Frank Oberlin vs Jack Quinn | Seventh | 5 out |
| Thursday, May 5 |
| » Lost to Athletics (9-4), 10-1 | Shibe Park (0-1) | 6-12 | Lost 2 |
| » Starters: Dixie Walker vs Cy Morgan | Seventh | 5½ out |
| Friday, May 6 |
| » Lost to Athletics (10-4), 4-3 | Shibe Park (0-2) | 6-13 | Lost 3 |
| » Starters: Walter Johnson vs Harry Krause | Seventh | 6½ out |
| Saturday, May 7 |
| » Lost to Athletics (11-4), 6-3 | Shibe Park (0-3) | 6-14 | Lost 4 |
| » Starters: Bob Groom vs Chief Bender | Seventh | 7½ out |
| Monday, May 9 |
| » Lost to Athletics (12-4), 10-2 | Shibe Park (0-4) | 6-15 | Lost 5 |
| » Starters: Dolly Gray vs Eddie Plank | Seventh | 8½ out |
| Tuesday, May 10 |
| » Lost to White Sox (8-9), 10-3 | American League Park II (4-7) | 6-16 | Lost 6 |
| » Starters: Doc White vs Walter Johnson | Seventh | 9 out |
| Friday, May 13 |
| » Defeated White Sox (8-10), 5-1 | American League Park II (5-7) | 7-16 | |
| » Starters: Irv Young vs Bob Groom | Seventh | 9½ out |
| Saturday, May 14 |
| » Defeated Indians (12-9), 1-0 | American League Park II (6-7) | 8-16 | Won 2 |
| » Starters: Addie Joss vs Walter Johnson | Seventh | 9½ out |
| Monday, May 16 |
| » Defeated Indians (12-10), 3-1 | American League Park II (7-7) | 9-16 | Won 3 |
| » Starters: Cy Falkenberg vs Doc Reisling | Seventh | 9½ out |
| Tuesday, May 17 |
| » Lost to Indians (13-10), 2-1 | American League Park II (7-8) | 9-17 | |
| » Starters: Fred Link vs Dixie Walker | Seventh | 10½ out |
| Wednesday, May 18 |
| » Defeated Indians (13-11), 4-3 | American League Park II (8-8) | 10-17 | |
| » Starters: Willie Mitchell vs Bob Groom | Sixth | 10½ out |
| Thursday, May 19 |
| » Defeated Browns (4-20), 5-0 | American League Park II (9-8) | 11-17 | Won 2 |
| » Starters: Bill Grahame vs Walter Johnson | Sixth | 9½ out |
| Friday, May 20 |
| » Tied Browns, 1-1 | American League Park II (9-8) | 11-17 | |
| » Starters: Joe Lake vs Dixie Walker | Sixth | 10 out |
| Saturday, May 21 |
| » Lost to Browns (5-20), 3-2 | American League Park II (9-9) | 11-18 | |
| » Starters: Jack Gilligan vs Bob Groom | Sixth | 11 out |
| Monday, May 23 |
| » Defeated Browns (5-21), 7-2 | American League Park II (10-9) | 12-18 | |
| » Starters: Bill Grahame vs Walter Johnson | Sixth | 10 out |
| Tuesday, May 24 |
| » Defeated Tigers (17-14), 3-2 | American League Park II (11-9) | 13-18 | Won 2 |
| » Starters: George Mullin vs Dolly Gray | Sixth | 9 out |
| Wednesday, May 25 |
| » Defeated Tigers (17-15), 2-0 | American League Park II (12-9) | 14-18 | Won 3 |
| » Starters: Ed Summers vs Bob Groom | Sixth | 9 out |
| Thursday, May 26 |
| » Lost to Tigers (18-15), 5-1 | American League Park II (12-10) | 14-19 | |
| » Starters: Ed Killian vs Doc Reisling | Sixth | 10 out |
| Friday, May 27 |
| » Defeated Tigers (18-16), 2-1 | American League Park II (13-10) | 15-19 | |
| » Starters: Sailor Stroud vs Walter Johnson | Sixth | 10 out |
| Saturday, May 28 |
| » Defeated Yankees (20-10), 4-3 | Hilltop Park (2-2) | 16-19 | Won 2 |
| » Starters: Dixie Walker vs Rube Manning | Fifth | 10 out |
| Monday, May 30 |
| » Lost to Yankees (21-10), 3-1 | Hilltop Park (2-3) | 16-20 | |
| » Starters: Frank Oberlin vs Russ Ford | Sixth | 11 out |
| » Lost to Yankees (22-10), 3-0 | Hilltop Park (2-4) | 16-21 | Lost 2 |
| » Starters: Bob Groom vs Hippo Vaughn | Sixth | 11 out |
| Tuesday, May 31 |
| » Lost to Yankees (23-10), 5-1 | Hilltop Park (2-5) | 16-22 | Lost 3 |
| » Starters: Walter Johnson vs Jack Quinn | Sixth | 11½ out |
| Friday, June 3 |
| » Lost to Indians (15-18), 7-2 | League Park II (0-1) | 16-23 | Lost 4 |
| » Starters: Bob Groom vs Cy Falkenberg | Sixth | 11½ out |
| Saturday, June 4 |
| » Defeated Indians (15-19), 8-2 | League Park II (1-1) | 17-23 | |
| » Starters: Walter Johnson vs Cy Young | Sixth | 10½ out |
| Monday, June 6 |
| » Lost to Tigers (27-16), 4-1 | Bennett Park (0-1) | 17-24 | |
| » Starters: Dolly Gray vs George Mullin | Sixth | 11 out |
| Tuesday, June 7 |
| » Lost to Tigers (28-16), 4-2 | Bennett Park (0-2) | 17-25 | Lost 2 |
| » Starters: Doc Reisling vs Ed Killian | Sixth | 12 out |
| Wednesday, June 8 |
| » Lost to Tigers (29-16), 5-1 | Bennett Park (0-3) | 17-26 | Lost 3 |
| » Starters: Bob Groom vs Ed Summers | Sixth | 12½ out |
| Thursday, June 9 |
| » Defeated Tigers (29-17), 7-1 | Bennett Park (1-3) | 18-26 | |
| » Starters: Walter Johnson vs Bill Donovan | Sixth | 12 out |
| Friday, June 10 |
| » Defeated White Sox (15-24), 1-0 | South Side Park III (1-0) | 19-26 | Won 2 |
| » Starters: Dixie Walker vs Ed Walsh | Sixth | 11 out |
| Saturday, June 11 |
| » Defeated White Sox (15-25), 3-0 | South Side Park III (2-0) | 20-26 | Won 3 |
| » Starters: Doc Reisling vs Frank Smith | Sixth | 11 out |
| Sunday, June 12 |
| » Defeated White Sox (15-26), 2-0 | South Side Park III (3-0) | 21-26 | Won 4 |
| » Starters: Bob Groom vs Irv Young | Sixth | 10 out |
| Monday, June 13 |
| » Lost to White Sox (16-26), 2-1 | South Side Park III (3-1) | 21-27 | |
| » Starters: Walter Johnson vs Fred Olmstead | Sixth | 10½ out |
| Wednesday, June 15 |
| » Lost to Browns (10-35), 5-4 | Sportsman's Park III (0-1) | 21-28 | Lost 2 |
| » Starters: Dixie Walker vs Joe Lake | Sixth | 11 out |
| Thursday, June 16 |
| » Defeated Browns (10-36), 6-2 | Sportsman's Park III (1-1) | 22-28 | |
| » Starters: Doc Reisling vs Bill Bailey | Sixth | 11 out |
| Saturday, June 18 |
| » Lost to Browns (11-36), 9-0 | Sportsman's Park III (1-2) | 22-29 | |
| » Starters: Bob Groom vs Bob Spade | Sixth | 11 out |
| Sunday, June 19 |
| » Defeated Browns (11-37), 4-1 | Sportsman's Park III (2-2) | 23-29 | |
| » Starters: Walter Johnson vs Joe Lake | Sixth | 10 out |
| Tuesday, June 21 |
| » Lost to Red Sox (26-24), 3-2 | Huntington Ave Baseball Grounds (1-4) | 23-30 | |
| » Starters: Dolly Gray vs Ray Collins | Sixth | 11½ out |
| Wednesday, June 22 |
| » Lost to Red Sox (27-24), 6-0 | Huntington Ave Baseball Grounds (1-5) | 23-31 | Lost 2 |
| » Starters: Doc Reisling vs Eddie Cicotte | Seventh | 13½ out |
| » Lost to Red Sox (28-24), 2-1 | Huntington Ave Baseball Grounds (1-6) | 23-32 | Lost 3 |
| » Starters: Walter Johnson vs Charlie Smith | Seventh | 13½ out |
| Thursday, June 23 |
| » Lost to Red Sox (29-24), 2-1 | Huntington Ave Baseball Grounds (1-7) | 23-33 | Lost 4 |
| » Starters: Frank Oberlin vs Ed Karger | Seventh | 13½ out |
| Friday, June 24 |
| » Lost to Red Sox (30-24), 2-1 | Huntington Ave Baseball Grounds (1-8) | 23-34 | Lost 5 |
| » Starters: Dolly Gray vs Charley Hall | Seventh | 13½ out |
| Saturday, June 25 |
| » Lost to Yankees (33-20), 7-4 | American League Park II (13-11) | 23-35 | Lost 6 |
| » Starters: Jack Warhop vs Walter Johnson | Seventh | 14½ out |
| » Major-league debuts: Bert Daniels (Yankees) |
| Monday, June 27 |
| » Lost to Yankees (34-20), 4-3 | American League Park II (13-12) | 23-36 | Lost 7 |
| » Starters: Jack Quinn vs Dixie Walker | Seventh | 15½ out |
| » Defeated Yankees (34-21), 2-1 | American League Park II (14-12) | 24-36 | |
| » Starters: Rube Manning vs Bob Groom | Seventh | 15½ out |
| Tuesday, June 28 |
| » Lost to Yankees (35-21), 9-7 | American League Park II (14-13) | 24-37 | |
| » Starters: Tom Hughes vs Doc Reisling | Seventh | 15½ out |
| Wednesday, June 29 |
| » Lost to Yankees (36-21), 2-1 | American League Park II (14-14) | 24-38 | Lost 2 |
| » Starters: Jack Warhop vs Dolly Gray | Seventh | 15½ out |
| Friday, July 1 |
| » Defeated Red Sox (32-28), 2-1 | American League Park II (15-14) | 25-38 | |
| » Starters: Charlie Smith vs Walter Johnson | Seventh | 16 out |
| Saturday, July 2 |
| » Lost to Red Sox (33-28), 3-2 | American League Park II (15-15) | 25-39 | |
| » Starters: Eddie Cicotte vs Bob Groom | Seventh | 17½ out |
| Monday, July 4 |
| » Lost to Red Sox (34-28), 3-2 | American League Park II (15-16) | 25-40 | Lost 2 |
| » Starters: Ed Karger vs Dixie Walker | Seventh | 18½ out |
| » Lost to Red Sox (35-28), 6-3 | American League Park II (15-17) | 25-41 | Lost 3 |
| » Starters: Ray Collins vs Dolly Gray | Seventh | 18½ out |
| Tuesday, July 5 |
| » Lost to Athletics (44-22), 3-2 | American League Park II (15-18) | 25-42 | Lost 4 |
| » Starters: Eddie Plank vs Walter Johnson | Seventh | 19½ out |
| Wednesday, July 6 |
| » Lost to Athletics (45-22), 3-2 | American League Park II (15-19) | 25-43 | Lost 5 |
| » Starters: Cy Morgan vs Bob Groom | Seventh | 20½ out |
| Thursday, July 7 |
| » Defeated Athletics (45-23), 4-1 | American League Park II (16-19) | 26-43 | |
| » Starters: Jack Coombs vs Dolly Gray | Seventh | 19½ out |
| Friday, July 8 |
| » Defeated Browns (21-46), 12-3 | American League Park II (17-19) | 27-43 | Won 2 |
| » Starters: Joe Lake vs Walter Johnson | Seventh | 19½ out |
| » Major-league debuts: John Henry (Senators) |
| Saturday, July 9 |
| » Lost to Browns (22-46), 9-6 | American League Park II (17-20) | 27-44 | |
| » Starters: Jack Powell vs Bob Groom | Seventh | 20 out |
| » Defeated Browns (22-47), 3-2 | American League Park II (18-20) | 28-44 | |
| » Starters: Bill Bailey vs Doc Reisling | Seventh | 20 out |
| Monday, July 11 |
| » Defeated Browns (22-48), 6-2 | American League Park II (19-20) | 29-44 | Won 2 |
| » Starters: Bob Spade vs Bob Groom | Seventh | 20 out |
| Tuesday, July 12 |
| » Tied Browns, 4-4 | American League Park II (19-20) | 29-44 | |
| » Starters: Bill Crouch vs Walter Johnson | Seventh | 20½ out |
| » Major-league debuts: Bill Crouch (Browns) |
| Wednesday, July 13 |
| » Lost to Tigers (42-35), 7-6 | Bennett Park (1-4) | 29-45 | |
| » Starters: Dolly Gray vs George Mullin | Seventh | 21½ out |
| Thursday, July 14 |
| » Lost to Tigers (43-35), 7-1 | Bennett Park (1-5) | 29-46 | Lost 2 |
| » Starters: Doc Reisling vs Bill Donovan | Seventh | 21½ out |
| Friday, July 15 |
| » Defeated Tigers (43-36), 7-3 | Bennett Park (2-5) | 30-46 | |
| » Starters: Bob Groom vs Ed Killian | Seventh | 21½ out |
| Sunday, July 17 |
| » Lost to Tigers (44-36), 1-0 | Burns Park (0-1) | 30-47 | |
| » Starters: Walter Johnson vs Ed Willett | Seventh | 22½ out |
| Tuesday, July 19 |
| » Defeated Indians (33-40), 7-0 | American League Park II (20-20) | 31-47 | |
| » Starters: Spec Harkness vs Dolly Gray | Seventh | 23½ out |
| » Lost to Indians (34-40), 5-2 | American League Park II (20-21) | 31-48 | |
| » Starters: Cy Young vs Doc Reisling | Seventh | 23½ out |
| Wednesday, July 20 |
| » Defeated Indians (34-41), 8-4 | American League Park II (21-21) | 32-48 | |
| » Starters: Willie Mitchell vs Bob Groom | Sixth | 23½ out |
| Thursday, July 21 |
| » Defeated Indians (34-42), 8-1 | American League Park II (22-21) | 33-48 | Won 2 |
| » Starters: Fred Link vs Doc Reisling | Sixth | 22½ out |
| Friday, July 22 |
| » Lost to White Sox (33-48), 5-1 | American League Park II (22-22) | 33-49 | |
| » Starters: Doc White vs Dolly Gray | Sixth | 22 out |
| » Defeated White Sox (33-49), 2-0 | American League Park II (23-22) | 34-49 | |
| » Starters: Fred Olmstead vs Bob Groom | Sixth | 22 out |
| Saturday, July 23 |
| » Defeated White Sox (33-50), 4-1 | American League Park II (24-22) | 35-49 | Won 2 |
| » Starters: Frank Lange vs Walter Johnson | Sixth | 22 out |
| Monday, July 25 |
| » Lost to White Sox (34-50), 4-2 | American League Park II (24-23) | 35-50 | |
| » Starters: Ed Walsh vs Doc Reisling | Sixth | 22 out |
| » Defeated White Sox (34-51), 5-1 | American League Park II (25-23) | 36-50 | |
| » Starters: Frank Smith vs Bob Groom | Sixth | 22 out |
| Tuesday, July 26 |
| » Lost to White Sox (35-51), 3-2 | American League Park II (25-24) | 36-51 | |
| » Starters: Doc White vs Walter Johnson | Sixth | 22½ out |
| Wednesday, July 27 |
| » Defeated Athletics (58-29), 5-4 | Shibe Park (1-4) | 37-51 | |
| » Starters: Dolly Gray vs Jimmy Dygert | Sixth | 21½ out |
| Thursday, July 28 |
| » Defeated Athletics (58-30), 6-5 | Shibe Park (2-4) | 38-51 | Won 2 |
| » Starters: Doc Reisling vs Cy Morgan | Sixth | 20½ out |
| Friday, July 29 |
| » Lost to Athletics (59-30), 4-0 | Shibe Park (2-5) | 38-52 | |
| » Starters: Bob Groom vs Jack Coombs | Sixth | 21½ out |
| Saturday, July 30 |
| » Lost to Athletics (60-30), 7-5 | Shibe Park (2-6) | 38-53 | Lost 2 |
| » Starters: Walter Johnson vs Chief Bender | Sixth | 22½ out |
| Monday, August 1 |
| » Lost to Browns (26-61), 5-4 | Sportsman's Park III (2-3) | 38-54 | Lost 3 |
| » Starters: Dixie Walker vs Rube Waddell | Sixth | 22½ out |
| Tuesday, August 2 |
| » Lost to Browns (27-61), 5-3 | Sportsman's Park III (2-4) | 38-55 | Lost 4 |
| » Starters: Dolly Gray vs Ed Kinsella | Sixth | 23½ out |
| Thursday, August 4 |
| » Defeated Browns (27-62), 9-1 | Sportsman's Park III (3-4) | 39-55 | |
| » Starters: Walter Johnson vs Farmer Ray | Sixth | 24 out |
| » Lost to Browns (28-62), 5-0 | Sportsman's Park III (3-5) | 39-56 | |
| » Starters: Bob Groom vs Joe Lake | Sixth | 24 out |
| Friday, August 5 |
| » Lost to White Sox (37-57), 5-2 | Comiskey Park I (0-1) | 39-57 | Lost 2 |
| » Starters: Dolly Gray vs Doc White | Sixth | 25 out |
| Saturday, August 6 |
| » Defeated White Sox (37-58), 5-1 | Comiskey Park I (1-1) | 40-57 | |
| » Starters: Doc Reisling vs Fred Olmstead | Sixth | 25 out |
| Sunday, August 7 |
| » Lost to White Sox (38-58), 4-0 | Comiskey Park I (1-2) | 40-58 | |
| » Starters: Bob Groom vs Ed Walsh | Sixth | 26 out |
| Monday, August 8 |
| » Defeated White Sox (38-59), 3-2 | Comiskey Park I (2-2) | 41-58 | |
| » Starters: Walter Johnson vs Irv Young | Sixth | 26 out |
| Tuesday, August 9 |
| » Lost to Indians (46-50), 7-1 | League Park II (1-2) | 41-59 | |
| » Starters: Doc Reisling vs Cy Young | Sixth | 26½ out |
| » Defeated Indians (46-51), 1-0 | League Park II (2-2) | 42-59 | |
| » Starters: Dixie Walker vs Spec Harkness | Sixth | 26½ out |
| » Major-league debuts: Eddie Ainsmith (Senators) |
| Wednesday, August 10 |
| » Lost to Indians (47-51), 3-2 | League Park II (2-3) | 42-60 | |
| » Starters: Ed Moyer vs Willie Mitchell | Sixth | 27½ out |
| » Tied Indians, 0-0 | League Park II (2-3) | 42-60 | |
| » Starters: Dolly Gray vs Elmer Koestner | Sixth | 27½ out |
| Thursday, August 11 |
| » Defeated Indians (47-52), 6-0 | League Park II (3-3) | 43-60 | |
| » Starters: Walter Johnson vs Harry Fanwell | Sixth | 26 out |
| » Defeated Indians (47-53), 4-3 | League Park II (4-3) | 44-60 | Won 2 |
| » Starters: Dixie Walker vs Cy Falkenberg | Sixth | 26 out |
| Friday, August 12 |
| » Defeated Indians (47-54), 9-0 | League Park II (5-3) | 45-60 | Won 3 |
| » Starters: Doc Reisling vs Spec Harkness | Sixth | 26 out |
| Saturday, August 13 |
| » Defeated Tigers (58-47), 5-3 | Bennett Park (3-5) | 46-60 | Won 4 |
| » Starters: Dolly Gray vs Sailor Stroud | Fifth | 25½ out |
| Sunday, August 14 |
| » Lost to Tigers (59-47), 3-0 | Burns Park (0-2) | 46-61 | |
| » Starters: Dixie Walker vs Ed Willett | Sixth | 26 out |
| Monday, August 15 |
| » Defeated Tigers (59-48), 6-4 | American League Park II (26-24) | 47-61 | |
| » Starters: Ralph Works vs Walter Johnson | Sixth | 26½ out |
| Tuesday, August 16 |
| » Lost to Tigers (60-48), 8-3 | American League Park II (26-25) | 47-62 | |
| » Starters: Bill Donovan vs Bob Groom | Sixth | 27½ out |
| Wednesday, August 17 |
| » Lost to Tigers (61-48), 4-2 | American League Park II (26-26) | 47-63 | Lost 2 |
| » Starters: Ed Summers vs Dolly Gray | Sixth | 27½ out |
| Thursday, August 18 |
| » Defeated Indians (49-59), 6-1 | American League Park II (27-26) | 48-63 | |
| » Starters: George Kahler vs Dixie Walker | Sixth | 27½ out |
| Friday, August 19 |
| » Defeated Indians (49-60), 10-0 | American League Park II (28-26) | 49-63 | Won 2 |
| » Starters: Ben DeMott vs Walter Johnson | Sixth | 27½ out |
| Saturday, August 20 |
| » Lost to Indians (50-60), 9-5 | American League Park II (28-27) | 49-64 | |
| » Starters: Cy Young vs Doc Reisling | Fifth | 28½ out |
| Monday, August 22 |
| » Defeated White Sox (44-66), 4-3 | American League Park II (29-27) | 50-64 | |
| » Starters: Doc White vs Dixie Walker | Sixth | 28½ out |
| Tuesday, August 23 |
| » Lost to White Sox (45-66), 1-0 | American League Park II (29-28) | 50-65 | |
| » Starters: Ed Walsh vs Walter Johnson | Fifth | 29½ out |
| Wednesday, August 24 |
| » Defeated White Sox (45-67), 3-2 | American League Park II (30-28) | 51-65 | |
| » Starters: Fred Olmstead vs Dolly Gray | Sixth | 29½ out |
| Thursday, August 25 |
| » Lost to Tigers (65-51), 3-2 | American League Park II (30-29) | 51-66 | |
| » Starters: Ralph Works vs Bob Groom | Sixth | 29½ out |
| Saturday, August 27 |
| » Defeated Tigers (65-52), 3-1 | American League Park II (31-29) | 52-66 | |
| » Starters: Sailor Stroud vs Dixie Walker | Fifth | 29½ out |
| » Defeated Tigers (65-53), 5-4 | American League Park II (32-29) | 53-66 | Won 2 |
| » Starters: Ed Summers vs Walter Johnson | Fifth | 29½ out |
| Future Senator Ewald Pyle is born in St. Louis, MO. |
| Monday, August 29 |
| » Defeated Browns (35-80), 4-0 | American League Park II (33-29) | 54-66 | Won 3 |
| » Starters: Marc Hall vs Dolly Gray | Fifth | 28 out |
| » Defeated Browns (35-81), 5-4 | American League Park II (34-29) | 55-66 | Won 4 |
| » Starters: Farmer Ray vs Doc Reisling | Fifth | 28 out |
| Tuesday, August 30 |
| » Lost to Browns (36-81), 4-0 | American League Park II (34-30) | 55-67 | |
| » Starters: Barney Pelty vs Bob Groom | Fifth | 29 out |
| Wednesday, August 31 |
| » Defeated Browns (36-82), 8-0 | American League Park II (35-30) | 56-67 | |
| » Starters: Bill Bailey vs Walter Johnson | Fifth | 28 out |
| Friday, September 2 |
| » Lost to Athletics (83-37), 5-1 | American League Park II (35-31) | 56-68 | |
| » Starters: Jack Coombs vs Dixie Walker | Fifth | 30 out |
| » Lost to Athletics (84-37), 2-1 | American League Park II (35-32) | 56-69 | Lost 2 |
| » Starters: Cy Morgan vs Dolly Gray | Fifth | 30 out |
| Saturday, September 3 |
| » Defeated Athletics (84-38), 3-1 | American League Park II (36-32) | 57-69 | |
| » Starters: Chief Bender vs Walter Johnson | Fifth | 29 out |
| Future Senator Jack Redmond is born in Florence, AZ. |
| Monday, September 5 |
| » Defeated Red Sox (72-51), 4-1 | Huntington Ave Baseball Grounds (2-8) | 58-69 | Won 2 |
| » Starters: Dixie Walker vs Charley Hall | Fifth | 29 out |
| » Lost to Red Sox (73-51), 5-0 | Huntington Ave Baseball Grounds (2-9) | 58-70 | |
| » Starters: Dolly Gray vs Joe Wood | Fifth | 29 out |
| Wednesday, September 7 |
| » Defeated Yankees (72-53), 2-1 | American League Park II (37-32) | 59-70 | |
| » Starters: Jack Quinn vs Walter Johnson | Fifth | 28½ out |
| Thursday, September 8 |
| » Lost to Yankees (73-53), 8-2 | American League Park II (37-33) | 59-71 | |
| » Starters: Jack Warhop vs Dixie Walker | Fourth | 29½ out |
| Friday, September 9 |
| » Lost to Yankees (74-53), 3-1 | American League Park II (37-34) | 59-72 | Lost 2 |
| » Starters: Ray Fisher vs Dolly Gray | Fifth | 30½ out |
| Future Senator Bud Thomas is born in Faber, VA. |
| Saturday, September 10 |
| » Lost to Athletics (89-40), 3-2 | Shibe Park (2-7) | 59-73 | Lost 3 |
| » Starters: Walter Johnson vs Cy Morgan | Fifth | 31½ out |
| Monday, September 12 |
| » Lost to Athletics (90-40), 6-0 | Shibe Park (2-8) | 59-74 | Lost 4 |
| » Starters: Doc Reisling vs Jack Coombs | Fifth | 32½ out |
| » Major-league debuts: Bill Cunningham (Senators) |
| Tuesday, September 13 |
| » Lost to Athletics (91-40), 6-0 | Shibe Park (2-9) | 59-75 | Lost 5 |
| » Starters: Dolly Gray vs Jimmy Dygert | Fifth | 33½ out |
| Wednesday, September 14 |
| » Major-league debuts: Dave Skeels (Tigers) |
| Thursday, September 15 |
| » Lost to Indians (60-74), 3-0 | League Park II (5-4) | 59-76 | Lost 6 |
| » Starters: Walter Johnson vs Fred Blanding | Sixth | 34½ out |
| » Major-league debuts: Fred Blanding and Roger Peckinpaugh (Indians) |
| Friday, September 16 |
| » Lost to Indians (61-74), 6-5 | League Park II (5-5) | 59-77 | Lost 7 |
| » Starters: Dixie Walker vs Willie Mitchell | Sixth | 35½ out |
| Saturday, September 17 |
| » Lost to Indians (62-74), 7-2 | League Park II (5-6) | 59-78 | Lost 8 |
| » Starters: Bob Groom vs George Kahler | Sixth | 35½ out |
| Monday, September 19 |
| » Tied Tigers, 6-6 | Bennett Park (3-5) | 59-78 | |
| » Starters: Dolly Gray vs Ralph Works | Sixth | 35½ out |
| Tuesday, September 20 |
| » Lost to Tigers (79-60), 4-3 | Bennett Park (3-6) | 59-79 | Lost 9 |
| » Starters: Ed Moyer vs Bill Donovan | Sixth | 37 out |
| » Lost to Tigers (80-60), 6-1 | Bennett Park (3-7) | 59-80 | Lost 10 |
| » Starters: Bill Otey vs George Mullin | Sixth | 37 out |
| Saturday, September 24 |
| » Defeated Browns (43-98), 6-3 | Sportsman's Park III (4-5) | 60-80 | |
| » Starters: Walter Johnson vs Ray Boyd | Fifth | 35½ out |
| Sunday, September 25 |
| » Lost to Browns (44-98), 2-1 | Sportsman's Park III (4-6) | 60-81 | |
| » Starters: Dixie Walker vs Roy Mitchell | Sixth | 35½ out |
| » Defeated Browns (44-99), 3-0 | Sportsman's Park III (5-6) | 61-81 | |
| » Starters: Walter Johnson vs Alex Malloy | Sixth | 35½ out |
| Tuesday, September 27 |
| » Lost to White Sox (62-81), 2-0 | Comiskey Park I (2-3) | 61-82 | |
| » Starters: Dolly Gray vs Jim Scott | Sixth | 36½ out |
| » Defeated White Sox (62-82), 3-2 | Comiskey Park I (3-3) | 62-82 | |
| » Starters: Bob Groom vs Fred Olmstead | Sixth | 36½ out |
| Wednesday, September 28 |
| » Defeated White Sox (62-83), 5-1 | Comiskey Park I (4-3) | 63-82 | Won 2 |
| » Starters: Walter Johnson vs Doc White | Sixth | 35½ out |
| Friday, September 30 |
| » Defeated Yankees (82-62), 6-3 | Hilltop Park (3-5) | 64-82 | Won 3 |
| » Starters: Bob Groom vs Jack Warhop | Sixth | 35½ out |
| Saturday, October 1 |
| » Lost to Yankees (83-62), 7-2 | Hilltop Park (3-6) | 64-83 | |
| » Starters: Dolly Gray vs Russ Ford | Sixth | 36½ out |
| Monday, October 3 |
| » Defeated Yankees (83-63), 4-0 | Hilltop Park (4-6) | 65-83 | |
| » Starters: Walter Johnson vs Hippo Vaughn | Sixth | 36½ out |
| Tuesday, October 4 |
| » Lost to Yankees (84-63), 8-5 | Hilltop Park (4-7) | 65-84 | |
| » Starters: Ed Moyer vs Jack Quinn | Sixth | 37½ out |
| Wednesday, October 5 |
| » Tied Red Sox, 5-5 | American League Park II (37-34) | 65-84 | |
| » Starters: Ben Hunt vs Bob Groom | Sixth | 37 out |
| Thursday, October 6 |
| » Lost to Red Sox (81-69), 5-2 | American League Park II (37-35) | 65-85 | Lost 2 |
| » Starters: Ray Collins vs Dolly Gray | Seventh | 36½ out |
| » Defeated Red Sox (81-70), 6-5 | American League Park II (38-35) | 66-85 | |
| » Starters: Marty McHale vs Dixie Walker | Seventh | 36½ out |
Game information provided by Retrosheet (www.retrosheet.org) |