| Monday, April 12 |
| » Major-league debuts: Ray Demmitt (Yankees) |
| Tuesday, April 13 |
| » Major-league debuts: Dolly Gray and Bob Groom (Senators) George McConnell (Yankees) |
| Wednesday, April 14 |
| » Defeated Browns (0-1), 4-2 | Sportsman's Park III (1-0) | 1-0 | |
| » Starters: Addie Joss vs Jack Powell | First | -- |
| Thursday, April 15 |
| » Defeated Browns (0-2), 4-3 | Sportsman's Park III (2-0) | 2-0 | Won 2 |
| » Starters: Cy Young vs Barney Pelty | First | -- |
| Friday, April 16 |
| » Lost to Browns (1-2), 6-5 | Sportsman's Park III (2-1) | 2-1 | |
| » Starters: Heinie Berger vs Bill Dinneen | Third | 1 out |
| Saturday, April 17 |
| » Lost to Tigers (4-0), 6-5 | Bennett Park (0-1) | 2-2 | Lost 2 |
| » Starters: Bob Rhoads vs Ed Willett | Third | 2 out |
| » Major-league debuts: Ted Easterly (Indians) |
| Sunday, April 18 |
| » Lost to Tigers (5-0), 3-2 | Burns Park (0-1) | 2-3 | Lost 3 |
| » Starters: Lucky Wright vs George Mullin | Fourth | 3 out |
| Monday, April 19 |
| » Major-league debuts: Jimmy Austin (Yankees) |
| Tuesday, April 20 |
| » Defeated Tigers (5-1), 12-2 | Bennett Park (1-1) | 3-3 | |
| » Starters: Cy Young vs Ed Lafitte | Fourth | 2 out |
| Thursday, April 22 |
| » Lost to Browns (3-3), 6-4 | League Park I (0-1) | 3-4 | |
| » Starters: Bill Grahame vs Addie Joss | Fourth | 2 out |
| Friday, April 23 |
| » Lost to Browns (4-3), 3-1 | League Park I (0-2) | 3-5 | Lost 2 |
| » Starters: Barney Pelty vs Cy Young | Fifth | 3 out |
| Saturday, April 24 |
| » Defeated Browns (4-4), 7-3 | League Park I (1-2) | 4-5 | |
| » Starters: Rube Waddell vs Carl Sitton | Fourth | 2½ out |
| Sunday, April 25 |
| » Lost to Tigers (7-3), 3-0 | Burns Park (0-2) | 4-6 | |
| » Starters: Lucky Wright vs Ed Summers | Fifth | 3 out |
| Monday, April 26 |
| » Lost to Tigers (8-3), 4-2 | League Park I (1-3) | 4-7 | Lost 2 |
| » Starters: Ed Willett vs Bob Rhoads | Sixth | 4 out |
| Wednesday, April 28 |
| » Lost to Tigers (9-3), 8-1 | League Park I (1-4) | 4-8 | Lost 3 |
| » Starters: George Mullin vs Cy Young | Sixth | 5 out |
| Saturday, May 1 |
| » Major-league debuts: Ralph Works (Tigers) |
| Sunday, May 2 |
| » Defeated Browns (4-10), 1-0 | Sportsman's Park III (3-1) | 5-8 | |
| » Starters: Addie Joss vs Jack Powell | Fifth | 6 out |
| » Major-league debuts: Art Griggs (Browns) |
| Tuesday, May 4 |
| » Defeated White Sox (7-7), 10-2 | League Park I (2-4) | 6-8 | Won 2 |
| » Starters: Frank Smith vs Cy Young | Fifth | 4½ out |
| Wednesday, May 5 |
| » Lost to White Sox (8-7), 6-5 | League Park I (2-5) | 6-9 | |
| » Starters: Frank Owen vs Lucky Wright | Fourth | 5½ out |
| Thursday, May 6 |
| » Defeated White Sox (8-8), 2-1 | League Park I (3-5) | 7-9 | |
| » Starters: Jim Scott vs Heinie Berger | Fifth | 5½ out |
| Saturday, May 8 |
| » Defeated White Sox (8-9), 8-4 | League Park I (4-5) | 8-9 | Won 2 |
| » Starters: Frank Smith vs Bob Rhoads | Fifth | 5 out |
| Sunday, May 9 |
| » Lost to White Sox (9-9), 4-2 | South Side Park III (0-1) | 8-10 | |
| » Starters: Cy Young vs Ed Walsh | Fifth | 5 out |
| » Defeated White Sox (9-10), 4-1 | South Side Park III (1-1) | 9-10 | |
| » Starters: Heinie Berger vs Jim Scott | Fifth | 5 out |
| Tuesday, May 11 |
| » Lost to Red Sox (11-8), 5-1 | League Park I (4-6) | 9-11 | |
| » Starters: Eddie Cicotte vs Lucky Wright | Fifth | 6 out |
| Wednesday, May 12 |
| » Lost to Red Sox (12-8), 3-2 | League Park I (4-7) | 9-12 | Lost 2 |
| » Starters: Charlie Chech vs Heinie Berger | Sixth | 7 out |
| Thursday, May 13 |
| » Lost to Red Sox (13-8), 8-1 | League Park I (4-8) | 9-13 | Lost 3 |
| » Starters: Cy Morgan vs Cy Young | Sixth | 7 out |
| Saturday, May 15 |
| » Lost to Yankees (13-9), 4-3 | League Park I (4-9) | 9-14 | Lost 4 |
| » Starters: Jack Warhop vs Addie Joss | Sixth | 7½ out |
| Monday, May 17 |
| » Lost to Yankees (14-9), 6-5 | League Park I (4-10) | 9-15 | Lost 5 |
| » Starters: Joe Lake vs Heinie Berger | Sixth | 8 out |
| Tuesday, May 18 |
| » Lost to Yankees (15-9), 4-2 | League Park I (4-11) | 9-16 | Lost 6 |
| » Starters: Rube Manning vs Glenn Liebhardt | Sixth | 8 out |
| Wednesday, May 19 |
| » Defeated Senators (6-18), 7-4 | League Park I (5-11) | 10-16 | |
| » Starters: Charlie Smith vs Cy Young | Sixth | 7 out |
| Thursday, May 20 |
| » Lost to Senators (7-18), 3-2 | League Park I (5-12) | 10-17 | |
| » Starters: Walter Johnson vs Addie Joss | Sixth | 8 out |
| Friday, May 21 |
| » Defeated Senators (7-19), 4-1 | League Park I (6-12) | 11-17 | |
| » Starters: Bob Groom vs Cy Falkenberg | Seventh | 7 out |
| Saturday, May 22 |
| » Lost to Senators (8-19), 4-1 | League Park I (6-13) | 11-18 | |
| » Starters: Walter Johnson vs Heinie Berger | Sixth | 7 out |
| Monday, May 24 |
| » Defeated Athletics (17-11), 6-2 | League Park I (7-13) | 12-18 | |
| » Starters: Jimmy Dygert vs Cy Young | Seventh | 7½ out |
| Tuesday, May 25 |
| » Lost to Athletics (18-11), 13-2 | League Park I (7-14) | 12-19 | |
| » Starters: Chief Bender vs Cy Falkenberg | Sixth | 8½ out |
| Wednesday, May 26 |
| » Defeated Athletics (18-12), 3-2 | League Park I (8-14) | 13-19 | |
| » Starters: Jack Coombs vs Heinie Berger | Seventh | 7½ out |
| Thursday, May 27 |
| » Defeated Browns (15-17), 5-2 | Sportsman's Park III (4-1) | 14-19 | Won 2 |
| » Starters: Addie Joss vs Barney Pelty | Sixth | 7 out |
| Friday, May 28 |
| » Defeated Browns (15-18), 3-1 | Sportsman's Park III (5-1) | 15-19 | Won 3 |
| » Starters: Cy Young vs Jack Powell | Sixth | 7 out |
| Sunday, May 30 |
| » Lost to Browns (16-18), 2-0 | Sportsman's Park III (5-2) | 15-20 | |
| » Starters: Heinie Berger vs Rube Waddell | Sixth | 8½ out |
| Monday, May 31 |
| » Lost to Browns (17-18), 6-3 | League Park I (8-15) | 15-21 | Lost 2 |
| » Starters: Dode Criss vs Bob Rhoads | Sixth | 9 out |
| » Defeated Browns (17-19), 5-1 | League Park I (9-15) | 16-21 | |
| » Starters: Bill Dinneen vs Addie Joss | Sixth | 9 out |
| Wednesday, June 2 |
| » Lost to Senators (12-25), 4-0 | American League Park II (0-1) | 16-22 | |
| » Starters: Cy Young vs Tom Hughes | Sixth | 9 out |
| Saturday, June 5 |
| » Defeated Senators (12-26), 6-3 | American League Park II (1-1) | 17-22 | |
| » Starters: Carl Sitton vs Walter Johnson | Sixth | 9½ out |
| Monday, June 7 |
| » Defeated Athletics (23-17), 3-1 | Shibe Park (1-0) | 18-22 | Won 2 |
| » Starters: Heinie Berger vs Eddie Plank | Fifth | 8½ out |
| Tuesday, June 8 |
| » Defeated Athletics (23-18), 2-0 | Shibe Park (2-0) | 19-22 | Won 3 |
| » Starters: Addie Joss vs Chief Bender | Fifth | 8½ out |
| Friday, June 11 |
| » Defeated Red Sox (24-20), 3-1 | Huntington Ave Baseball Grounds (1-0) | 20-22 | Won 4 |
| » Starters: Cy Young vs Biff Schlitzer | Fifth | 8 out |
| Saturday, June 12 |
| » Defeated Red Sox (24-21), 4-0 | Huntington Ave Baseball Grounds (2-0) | 21-22 | Won 5 |
| » Starters: Heinie Berger vs Eddie Cicotte | Fifth | 7 out |
| Monday, June 14 |
| » Defeated Red Sox (24-22), 3-1 | Huntington Ave Baseball Grounds (3-0) | 22-22 | Won 6 |
| » Starters: Addie Joss vs Frank Arellanes | Fifth | 7 out |
| Tuesday, June 15 |
| » Lost to Red Sox (25-22), 7-6 | Huntington Ave Baseball Grounds (3-1) | 22-23 | |
| » Starters: Glenn Liebhardt vs Eddie Cicotte | Fifth | 7 out |
| Wednesday, June 16 |
| » Defeated Yankees (23-21), 4-3 | Hilltop Park (1-0) | 23-23 | |
| » Starters: Cy Young vs Slow Joe Doyle | Fifth | 6 out |
| Thursday, June 17 |
| » Defeated Yankees (23-22), 3-2 | Hilltop Park (2-0) | 24-23 | Won 2 |
| » Starters: Heinie Berger vs Tom Hughes | Fourth | 6 out |
| Friday, June 18 |
| » Defeated Yankees (23-23), 10-4 | Hilltop Park (3-0) | 25-23 | Won 3 |
| » Starters: Addie Joss vs Lew Brockett | Third | 5 out |
| Saturday, June 19 |
| » Defeated Browns (19-30), 3-2 | League Park I (10-15) | 26-23 | Won 4 |
| » Starters: Bill Dinneen vs Carl Sitton | Third | 5 out |
| Sunday, June 20 |
| » Lost to White Sox (23-25), 4-0 | South Side Park III (1-2) | 26-24 | |
| » Starters: Cy Young vs Ed Walsh | Third | 6 out |
| » Defeated White Sox (23-26), 5-0 | South Side Park III (2-2) | 27-24 | |
| » Starters: Heinie Berger vs Jim Scott | Third | 6 out |
| Tuesday, June 22 |
| » Defeated White Sox (23-27), 3-2 | South Side Park III (3-2) | 28-24 | Won 2 |
| » Starters: Addie Joss vs Ed Walsh | Fourth | 6 out |
| » Defeated White Sox (23-28), 2-0 | South Side Park III (4-2) | 29-24 | Won 3 |
| » Starters: Bob Rhoads vs Frank Smith | Fourth | 6 out |
| Wednesday, June 23 |
| » Lost to White Sox (24-28), 4-3 | League Park I (10-16) | 29-25 | |
| » Starters: Lou Fiene vs Heinie Berger | Fourth | 7 out |
| Thursday, June 24 |
| » Defeated White Sox (24-29), 8-1 | League Park I (11-16) | 30-25 | |
| » Starters: Jim Scott vs Cy Young | Fourth | 7 out |
| Saturday, June 26 |
| » Lost to White Sox (25-29), 2-0 | League Park I (11-17) | 30-26 | |
| » Starters: Ed Walsh vs Addie Joss | Fourth | 8½ out |
| Sunday, June 27 |
| » Lost to Browns (20-38), 6-0 | Sportsman's Park III (5-3) | 30-27 | Lost 2 |
| » Starters: Heinie Berger vs Jack Powell | Fourth | 8½ out |
| » Defeated Browns (20-39), 11-3 | Sportsman's Park III (6-3) | 31-27 | |
| » Starters: Bob Rhoads vs Bill Dinneen | Fourth | 8½ out |
| Monday, June 28 |
| » Lost to Browns (21-39), 6-0 | Sportsman's Park III (6-4) | 31-28 | |
| » Starters: Carl Sitton vs Barney Pelty | Fourth | 9½ out |
| Tuesday, June 29 |
| » Lost to Tigers (43-20), 3-2 | Bennett Park (1-2) | 31-29 | Lost 2 |
| » Starters: Cy Young vs George Mullin | Fourth | 10½ out |
| Wednesday, June 30 |
| » Defeated Tigers (43-21), 7-1 | Bennett Park (2-2) | 32-29 | |
| » Starters: Addie Joss vs Bill Donovan | Fourth | 9½ out |
| Thursday, July 1 |
| » Lost to Tigers (44-21), 9-3 | League Park I (11-18) | 32-30 | |
| » Starters: Ed Willett vs Heinie Berger | Fourth | 10½ out |
| Friday, July 2 |
| » Lost to Tigers (45-21), 3-2 | League Park I (11-19) | 32-31 | Lost 2 |
| » Starters: George Suggs vs Bob Rhoads | Fourth | 11½ out |
| Saturday, July 3 |
| » Defeated Tigers (45-22), 4-1 | League Park I (12-19) | 33-31 | |
| » Starters: George Mullin vs Cy Young | Fourth | 10½ out |
| Sunday, July 4 |
| » Defeated White Sox (27-36), 3-0 | South Side Park III (5-2) | 34-31 | Won 2 |
| » Starters: Addie Joss vs Lou Fiene | Fourth | 10½ out |
| Monday, July 5 |
| » Defeated White Sox (27-37), 4-3 | League Park I (13-19) | 35-31 | Won 3 |
| » Starters: Ed Walsh vs Cy Falkenberg | Fourth | 9 out |
| » Defeated White Sox (27-38), 4-2 | League Park I (14-19) | 36-31 | Won 4 |
| » Starters: Doc White vs Bob Rhoads | Fourth | 9 out |
| Tuesday, July 6 |
| » Defeated Tigers (46-24), 6-0 | League Park I (15-19) | 37-31 | Won 5 |
| » Starters: Ed Summers vs Cy Young | Fourth | 8 out |
| Wednesday, July 7 |
| » Defeated Tigers (46-25), 4-3 | League Park I (16-19) | 38-31 | Won 6 |
| » Starters: George Mullin vs Addie Joss | Fourth | 7 out |
| Thursday, July 8 |
| » Defeated Senators (22-47), 3-2 | League Park I (17-19) | 39-31 | Won 7 |
| » Starters: Walter Johnson vs Cy Falkenberg | Fourth | 6 out |
| Friday, July 9 |
| » Lost to Senators (23-47), 4-3 | League Park I (17-20) | 39-32 | |
| » Starters: Tom Hughes vs Heinie Berger | Fourth | 6 out |
| Saturday, July 10 |
| » Defeated Senators (23-48), 4-0 | League Park I (18-20) | 40-32 | |
| » Starters: Bob Groom vs Cy Young | Fourth | 6 out |
| Monday, July 12 |
| » Defeated Senators (23-49), 3-0 | League Park I (19-20) | 41-32 | Won 2 |
| » Starters: Walter Johnson vs Bob Rhoads | Fourth | 5 out |
| Tuesday, July 13 |
| » Defeated Athletics (45-28), 1-0 | League Park I (20-20) | 42-32 | Won 3 |
| » Starters: Cy Morgan vs Addie Joss | Fourth | 5 out |
| Wednesday, July 14 |
| » Defeated Athletics (45-29), 4-3 | League Park I (21-20) | 43-32 | Won 4 |
| » Starters: Jack Coombs vs Cy Young | Fourth | 4½ out |
| Thursday, July 15 |
| » Defeated Athletics (45-30), 6-5 | League Park I (22-20) | 44-32 | Won 5 |
| » Starters: Chief Bender vs Bob Rhoads | Third | 5 out |
| Friday, July 16 |
| » Lost to Athletics (46-30), 3-0 | League Park I (22-21) | 44-33 | |
| » Starters: Cy Morgan vs Heinie Berger | Fourth | 5½ out |
| Saturday, July 17 |
| » Lost to Red Sox (48-34), 6-4 | League Park I (22-22) | 44-34 | Lost 2 |
| » Starters: Frank Arellanes vs Addie Joss | Fourth | 6½ out |
| Monday, July 19 |
| » Defeated Red Sox (48-35), 6-1 | League Park I (23-22) | 45-34 | |
| » Starters: Charlie Chech vs Cy Young | Fourth | 6½ out |
| » Lost to Red Sox (49-35), 8-2 | League Park I (23-23) | 45-35 | |
| » Starters: Frank Arellanes vs Bob Rhoads | Fourth | 6½ out |
| » Major-league debuts: Ray Collins (Red Sox) |
| Tuesday, July 20 |
| » Lost to Red Sox (50-35), 4-0 | League Park I (23-24) | 45-36 | Lost 2 |
| » Starters: Joe Wood vs Cy Falkenberg | Fourth | 6½ out |
| Wednesday, July 21 |
| » Defeated Red Sox (50-36), 4-2 | League Park I (24-24) | 46-36 | |
| » Starters: Jack Ryan vs Heinie Berger | Fourth | 6½ out |
| Thursday, July 22 |
| » Lost to Yankees (38-46), 1-0 | League Park I (24-25) | 46-37 | |
| » Starters: Slow Joe Doyle vs Addie Joss | Fourth | 7½ out |
| Saturday, July 24 |
| » Defeated Yankees (38-47), 2-0 | League Park I (25-25) | 47-37 | |
| » Starters: Joe Lake vs Cy Young | Fourth | 9 out |
| » Lost to Yankees (39-47), 3-2 | League Park I (25-26) | 47-38 | |
| » Starters: Rube Manning vs Glenn Liebhardt | Fourth | 9 out |
| Monday, July 26 |
| » Defeated Yankees (39-48), 2-1 | League Park I (26-26) | 48-38 | |
| » Starters: Tom Hughes vs Heinie Berger | Fourth | 8 out |
| Tuesday, July 27 |
| » Lost to Tigers (58-31), 3-1 | League Park I (26-27) | 48-39 | |
| » Starters: Ed Summers vs Addie Joss | Fourth | 9 out |
| Wednesday, July 28 |
| » Lost to Tigers (59-31), 5-4 | League Park I (26-28) | 48-40 | Lost 2 |
| » Starters: George Mullin vs Cy Young | Fourth | 10 out |
| Thursday, July 29 |
| » Lost to Athletics (53-37), 2-1 | Shibe Park (2-1) | 48-41 | Lost 3 |
| » Starters: Heinie Berger vs Cy Morgan | Fourth | 10½ out |
| » Lost to Athletics (54-37), 9-4 | Shibe Park (2-2) | 48-42 | Lost 4 |
| » Starters: Bob Rhoads vs Jack Coombs | Fourth | 10½ out |
| Friday, July 30 |
| » Lost to Athletics (55-37), 7-1 | Shibe Park (2-3) | 48-43 | Lost 5 |
| » Starters: Glenn Liebhardt vs Jimmy Dygert | Fourth | 10½ out |
| Saturday, July 31 |
| » Defeated Athletics (55-38), 3-1 | Shibe Park (3-3) | 49-43 | |
| » Starters: Addie Joss vs Cy Morgan | Fourth | 10½ out |
| » Lost to Athletics (56-38), 4-3 | Shibe Park (3-4) | 49-44 | |
| » Starters: Cy Young vs Jack Coombs | Fourth | 10½ out |
| Tuesday, August 3 |
| » Defeated Senators (26-69), 6-0 | American League Park II (2-1) | 50-44 | |
| » Starters: Heinie Berger vs Roy Witherup | Fourth | 8½ out |
| » Defeated Senators (26-70), 2-1 | American League Park II (3-1) | 51-44 | Won 2 |
| » Starters: Cy Falkenberg vs Charlie Smith | Fourth | 8½ out |
| Wednesday, August 4 |
| » Lost to Senators (27-70), 1-0 | American League Park II (3-2) | 51-45 | |
| » Starters: Addie Joss vs Walter Johnson | Fourth | 9½ out |
| » Lost to Senators (28-70), 6-2 | American League Park II (3-3) | 51-46 | Lost 2 |
| » Starters: Red Booles vs Tom Hughes | Fourth | 9½ out |
| Thursday, August 5 |
| » Defeated Senators (28-71), 9-4 | American League Park II (4-3) | 52-46 | |
| » Starters: Cy Young vs Dolly Gray | Fourth | 9½ out |
| » Lost to Senators (29-71), 2-0 | American League Park II (4-4) | 52-47 | |
| » Starters: Cy Falkenberg vs Charlie Smith | Fourth | 9½ out |
| Friday, August 6 |
| » Lost to Yankees (46-52), 8-0 | Hilltop Park (3-1) | 52-48 | Lost 2 |
| » Starters: Heinie Berger vs Slow Joe Doyle | Fourth | 10½ out |
| Saturday, August 7 |
| » Lost to Yankees (47-52), 5-2 | Hilltop Park (3-2) | 52-49 | Lost 3 |
| » Starters: Cy Young vs Rube Manning | Fourth | 10½ out |
| Monday, August 9 |
| » Lost to Yankees (48-52), 3-0 | Hilltop Park (3-3) | 52-50 | Lost 4 |
| » Starters: Cy Falkenberg vs Jack Warhop | Fourth | 10½ out |
| Tuesday, August 10 |
| » Defeated Yankees (48-53), 4-1 | Hilltop Park (4-3) | 53-50 | |
| » Starters: Heinie Berger vs Tom Hughes | Third | 9½ out |
| Wednesday, August 11 |
| » Lost to Red Sox (62-44), 4-2 | Huntington Ave Baseball Grounds (3-2) | 53-51 | |
| » Starters: Addie Joss vs Frank Arellanes | Third | 9½ out |
| Thursday, August 12 |
| » Lost to Red Sox (63-44), 5-4 | Huntington Ave Baseball Grounds (3-3) | 53-52 | Lost 2 |
| » Starters: Cy Young vs Joe Wood | Third | 10½ out |
| Friday, August 13 |
| » Lost to Red Sox (64-44), 7-2 | Huntington Ave Baseball Grounds (3-4) | 53-53 | Lost 3 |
| » Starters: Heinie Berger vs Eddie Cicotte | Third | 11½ out |
| Saturday, August 14 |
| » Lost to Red Sox (65-44), 3-1 | Huntington Ave Baseball Grounds (3-5) | 53-54 | Lost 4 |
| » Starters: Cy Falkenberg vs Frank Arellanes | Fourth | 12½ out |
| Tuesday, August 17 |
| » Defeated Browns (45-59), 2-1 | League Park I (27-28) | 54-54 | |
| » Starters: Jack Powell vs Addie Joss | Fourth | 11½ out |
| » Defeated Browns (45-60), 7-3 | League Park I (28-28) | 55-54 | Won 2 |
| » Starters: Bill Dinneen vs Cy Young | Fourth | 11½ out |
| Wednesday, August 18 |
| » Defeated Browns (45-61), 3-0 | League Park I (29-28) | 56-54 | Won 3 |
| » Starters: Bill Bailey vs Heinie Berger | Fourth | 11 out |
| » Defeated Browns (45-62), 3-2 | League Park I (30-28) | 57-54 | Won 4 |
| » Starters: Barney Pelty vs Cy Falkenberg | Fourth | 11 out |
| Thursday, August 19 |
| » Lost to Athletics (68-42), 2-1 | League Park I (30-29) | 57-55 | |
| » Starters: Cy Morgan vs Bob Rhoads | Fourth | 12 out |
| Friday, August 20 |
| » Lost to Athletics (69-42), 5-0 | League Park I (30-30) | 57-56 | Lost 2 |
| » Starters: Jack Coombs vs Carl Sitton | Fourth | 13 out |
| Saturday, August 21 |
| » Lost to Athletics (70-42), 10-6 | League Park I (30-31) | 57-57 | Lost 3 |
| » Starters: Jimmy Dygert vs Heinie Berger | Fourth | 14 out |
| Monday, August 23 |
| » Lost to Athletics (71-42), 12-6 | League Park I (30-32) | 57-58 | Lost 4 |
| » Manager: Deacon McGuire |
| » Starters: Cy Morgan vs Bob Rhoads | Fourth | 15 out |
| Tuesday, August 24 |
| » Defeated Senators (32-82), 7-0 | League Park I (31-32) | 58-58 | |
| » Starters: Roy Witherup vs Cy Falkenberg | Third | 14 out |
| Wednesday, August 25 |
| » Lost to Senators (33-82), 6-5 | League Park I (31-33) | 58-59 | |
| » Starters: Walter Johnson vs Bob Rhoads | Fourth | 15 out |
| Thursday, August 26 |
| » Defeated Senators (33-83), 8-2 | League Park I (32-33) | 59-59 | |
| » Starters: Bob Groom vs Cy Young | Fourth | 15 out |
| Friday, August 27 |
| » Defeated Red Sox (72-48), 5-3 | League Park I (33-33) | 60-59 | Won 2 |
| » Starters: Eddie Cicotte vs Cy Falkenberg | Fourth | 15 out |
| Saturday, August 28 |
| » Lost to Red Sox (73-48), 4-3 | League Park I (33-34) | 60-60 | |
| » Starters: William Matthews vs Addie Joss | Fourth | 16 out |
| Monday, August 30 |
| » Defeated Red Sox (73-49), 4-2 | League Park I (34-34) | 61-60 | |
| » Starters: Joe Wood vs Heinie Berger | Fourth | 16 out |
| Tuesday, August 31 |
| » Lost to Yankees (54-65), 4-1 | League Park I (34-35) | 61-61 | |
| » Starters: Slow Joe Doyle vs Cy Young | Fourth | 16½ out |
| » Defeated Yankees (54-66), 2-1 | League Park I (35-35) | 62-61 | |
| » Starters: Joe Lake vs Cy Falkenberg | Fourth | 16½ out |
| Thursday, September 2 |
| » Lost to Yankees (55-66), 6-1 | League Park I (35-36) | 62-62 | |
| » Starters: Tom Hughes vs Heinie Berger | Fifth | 17½ out |
| » Defeated Yankees (55-67), 2-1 | League Park I (36-36) | 63-62 | |
| » Starters: Jack Warhop vs Jerry Upp | Fifth | 17½ out |
| Friday, September 3 |
| » Tied Tigers, 1-1 | League Park I (36-36) | 63-62 | |
| » Starters: Ed Summers vs Addie Joss | Fifth | 17½ out |
| Saturday, September 4 |
| » Defeated Tigers (79-44), 4-0 | League Park I (37-36) | 64-62 | Won 2 |
| » Starters: George Mullin vs Cy Falkenberg | Fourth | 15½ out |
| » Defeated Tigers (79-45), 4-3 | League Park I (38-36) | 65-62 | Won 3 |
| » Starters: Bill Donovan vs Cy Young | Fourth | 15½ out |
| Sunday, September 5 |
| » Defeated White Sox (63-62), 6-1 | South Side Park III (6-2) | 66-62 | Won 4 |
| » Starters: Harry Otis vs Frank Smith | Fourth | 15½ out |
| Monday, September 6 |
| » Defeated White Sox (63-63), 5-2 | League Park I (39-36) | 67-62 | Won 5 |
| » Starters: Jim Scott vs Jerry Upp | Fourth | 16½ out |
| » Lost to White Sox (64-63), 5-3 | League Park I (39-37) | 67-63 | |
| » Starters: Fred Olmstead vs Heinie Berger | Fourth | 16½ out |
| Tuesday, September 7 |
| » Lost to Tigers (83-45), 6-4 | Bennett Park (2-3) | 67-64 | Lost 2 |
| » Starters: Addie Joss vs Ed Summers | Fourth | 17½ out |
| Wednesday, September 8 |
| » Defeated Tigers (83-46), 7-4 | Bennett Park (3-3) | 68-64 | |
| » Starters: Cy Falkenberg vs Bill Donovan | Fourth | 16½ out |
| Friday, September 10 |
| » Lost to Tigers (84-46), 2-1 | Bennett Park (3-4) | 68-65 | |
| » Starters: Cy Young vs George Mullin | Fourth | 18½ out |
| » Lost to Tigers (85-46), 9-1 | Bennett Park (3-5) | 68-66 | Lost 2 |
| » Starters: Jerry Upp vs Ralph Works | Fourth | 18½ out |
| Saturday, September 11 |
| » Lost to Tigers (86-46), 7-1 | Bennett Park (3-6) | 68-67 | Lost 3 |
| » Starters: Cy Falkenberg vs Ed Summers | Fourth | 19½ out |
| Sunday, September 12 |
| » Lost to White Sox (67-67), 1-0 | South Side Park III (6-3) | 68-68 | Lost 4 |
| » Starters: Harry Otis vs Frank Smith | Fifth | 20½ out |
| Monday, September 13 |
| » Lost to White Sox (68-67), 2-0 | South Side Park III (6-4) | 68-69 | Lost 5 |
| » Starters: Addie Joss vs Ed Walsh | Fifth | 21½ out |
| Tuesday, September 14 |
| » Tied White Sox, 4-4 | South Side Park III (6-4) | 68-69 | |
| » Starters: Harry Ables vs Fred Olmstead | Fifth | 21 out |
| Thursday, September 16 |
| » Lost to Yankees (62-73), 2-1 | Hilltop Park (4-4) | 68-70 | Lost 6 |
| » Starters: Fred Winchell vs Joe Lake | Fifth | 21 out |
| Friday, September 17 |
| » Lost to Yankees (63-73), 10-0 | Hilltop Park (4-5) | 68-71 | Lost 7 |
| » Starters: Cy Falkenberg vs Slow Joe Doyle | Fifth | 22 out |
| Saturday, September 18 |
| » Lost to Yankees (64-73), 5-3 | Hilltop Park (4-6) | 68-72 | Lost 8 |
| » Starters: Harry Otis vs Jack Quinn | Fifth | 22 out |
| Monday, September 20 |
| » Lost to Yankees (65-73), 9-4 | Hilltop Park (4-7) | 68-73 | Lost 9 |
| » Starters: Walt Doane vs Al Orth | Fifth | 22 out |
| Tuesday, September 21 |
| » Lost to Red Sox (82-59), 7-3 | Huntington Ave Baseball Grounds (3-6) | 68-74 | Lost 10 |
| » Starters: Cy Young vs Charlie Smith | Fifth | 22½ out |
| Wednesday, September 22 |
| » Lost to Red Sox (83-59), 3-1 | Huntington Ave Baseball Grounds (3-7) | 68-75 | Lost 11 |
| » Starters: Willie Mitchell vs Joe Wood | Fifth | 23½ out |
| » Major-league debuts: Willie Mitchell (Indians) |
| Thursday, September 23 |
| » Defeated Red Sox (83-60), 7-3 | Huntington Ave Baseball Grounds (4-7) | 69-75 | |
| » Starters: Harry Ables vs Charley Hall | Sixth | 23½ out |
| Saturday, September 25 |
| » Lost to Athletics (90-53), 5-0 | Shibe Park (3-5) | 69-76 | |
| » Starters: Addie Joss vs Chief Bender | Sixth | 25½ out |
| » Lost to Athletics (91-53), 3-0 | Shibe Park (3-6) | 69-77 | Lost 2 |
| » Starters: Cy Falkenberg vs Cy Morgan | Sixth | 25½ out |
| Monday, September 27 |
| » Defeated Athletics (91-54), 5-4 | Shibe Park (4-6) | 70-77 | |
| » Starters: Jerry Upp vs Jack Coombs | Sixth | 24½ out |
| Tuesday, September 28 |
| » Lost to Athletics (92-54), 7-0 | Shibe Park (4-7) | 70-78 | |
| » Starters: Cy Young vs Cy Morgan | Sixth | 25½ out |
| Wednesday, September 29 |
| » Lost to Senators (40-108), 2-1 | American League Park II (4-5) | 70-79 | Lost 2 |
| » Starters: Willie Mitchell vs Dixie Walker | Sixth | 27½ out |
| » Lost to Senators (41-108), 7-3 | American League Park II (4-6) | 70-80 | Lost 3 |
| » Starters: Fred Winchell vs Bob Groom | Sixth | 27½ out |
| Future Indian Oris Hockett is born in Amboy, IN. |
| Friday, October 1 |
| » Lost to Senators (42-108), 4-2 | American League Park II (4-7) | 70-81 | Lost 4 |
| » Starters: Harry Ables vs Dixie Walker | Sixth | 27 out |
| Saturday, October 2 |
| » Major-league debuts: Del Gainer (Tigers) |
| Sunday, October 3 |
| » Lost to Browns (61-88), 6-4 | Sportsman's Park III (6-5) | 70-82 | Lost 5 |
| » Starters: Fred Winchell vs Bill Bailey | Sixth | 27½ out |
| » Defeated Browns (61-89), 3-1 | Sportsman's Park III (7-5) | 71-82 | |
| » Starters: Willie Mitchell vs Harry Howell | Sixth | 27½ out |
| Future Indian Johnny Broaca is born in Lawrence, MA. |
| Friday, October 15 |
| Future Indian Mel Harder is born in Beemer, NE. |
| Wednesday, October 20 |
| Future Indian Bruce Campbell is born in Chicago, IL. |
| Friday, October 29 |
| Future Indian Ralph Winegarner is born in Benton, KS. |
| Thursday, November 4 |
| Future Indian Skeeter Webb is born in Meridian, MS. |
Game information provided by Retrosheet (www.retrosheet.org) |