| Friday, January 26 |
| Future Senator Charley Gelbert is born in Scranton, PA. |
| Sunday, January 28 |
| Future Senator Lyn Lary is born in Armona, CA. |
| Tuesday, February 13 |
| Future Senator Harry Kelley is born in Parkin, AR. |
| Wednesday, March 21 |
| Future Senator Shanty Hogan is born in Somerville, MA. |
| Sunday, March 25 |
| Former Senator Joe Cassidy dies in Chester, PA at the age of 24. |
| Thursday, April 12 |
| » Major-league debuts: Pug Bennett (Cardinals) |
| Saturday, April 14 |
| » Lost to Athletics (1-0), 4-3 | American League Park II (0-1) | 0-1 | |
| » Starters: Chief Bender vs Tom Hughes | Third | 1 out |
| » Major-league debuts: Art Brouthers (Athletics) |
| Sunday, April 15 |
| » Major-league debuts: Ed Karger (Pirates) |
| Monday, April 16 |
| » Lost to Athletics (2-0), 5-3 | American League Park II (0-2) | 0-2 | Lost 2 |
| » Starters: Jimmy Dygert vs Willie Sudhoff | Third | 2 out |
| Tuesday, April 17 |
| » Defeated Athletics (2-1), 5-2 | American League Park II (1-2) | 1-2 | |
| » Starters: Jimmy Dygert vs Cy Falkenberg | Fourth | 2 out |
| Wednesday, April 18 |
| » Lost to Athletics (3-1), 4-2 | Columbia Park (0-1) | 1-3 | |
| » Starters: Barney Wolfe vs Chief Bender | Fifth | 2½ out |
| Thursday, April 19 |
| » Defeated Athletics (3-2), 11-10 | Columbia Park (1-1) | 2-3 | |
| » Starters: Willie Sudhoff vs Eddie Plank | Fourth | 2 out |
| » Major-league debuts: Jack Hannifin (Athletics) |
| Friday, April 20 |
| » Defeated Red Sox (2-4), 10-1 | American League Park II (2-2) | 3-3 | Won 2 |
| » Starters: George Winter vs Cy Falkenberg | Fourth | 1½ out |
| Saturday, April 21 |
| » Defeated Red Sox (2-5), 4-3 | American League Park II (3-2) | 4-3 | Won 3 |
| » Starters: Bill Dinneen vs Charlie Smith | Fourth | 1½ out |
| Tuesday, April 24 |
| » Lost to Red Sox (3-5), 19-2 | American League Park II (3-3) | 4-4 | |
| » Starters: Jesse Tannehill vs Cy Falkenberg | Fourth | 1 out |
| Wednesday, April 25 |
| » Defeated Yankees (4-5), 7-2 | American League Park II (4-3) | 5-4 | |
| » Starters: Jack Chesbro vs Casey Patten | Second | 1 out |
| Thursday, April 26 |
| » Defeated Yankees (4-6), 5-3 | American League Park II (5-3) | 6-4 | Won 2 |
| » Starters: Jack Chesbro vs Frank Kitson | First | -- |
| Friday, April 27 |
| » Defeated Yankees (4-7), 5-2 | American League Park II (6-3) | 7-4 | Won 3 |
| » Starters: Al Orth vs Tom Hughes | First | -- |
| Saturday, April 28 |
| » Lost to Yankees (5-7), 5-1 | American League Park II (6-4) | 7-5 | |
| » Starters: Walter Clarkson vs Barney Wolfe | First | -- |
| Monday, April 30 |
| » Lost to Athletics (8-5), 6-3 | Columbia Park (1-2) | 7-6 | Lost 2 |
| » Starters: Cy Falkenberg vs Chief Bender | Third | 1 out |
| Tuesday, May 1 |
| » Lost to Athletics (9-5), 16-2 | Columbia Park (1-3) | 7-7 | Lost 3 |
| » Starters: Tom Hughes vs Eddie Plank | Fourth | 2 out |
| Wednesday, May 2 |
| » Defeated Red Sox (6-9), 3-2 | Huntington Ave Baseball Grounds (1-0) | 8-7 | |
| » Starters: Casey Patten vs Cy Young | Third | 1½ out |
| Thursday, May 3 |
| » Defeated Red Sox (6-10), 6-4 | Huntington Ave Baseball Grounds (2-0) | 9-7 | Won 2 |
| » Starters: Frank Kitson vs George Winter | Third | ½ out |
| Friday, May 4 |
| » Defeated Red Sox (6-11), 4-2 | Huntington Ave Baseball Grounds (3-0) | 10-7 | Won 3 |
| » Starters: Tom Hughes vs Bill Dinneen | First | -- |
| Monday, May 7 |
| » Lost to Yankees (9-9), 7-2 | Hilltop Park (0-1) | 10-8 | |
| » Starters: Cy Falkenberg vs Al Orth | Second | 1 out |
| Future Senator Syd Cohen is born in Baltimore, MD. |
| Tuesday, May 8 |
| » Defeated Yankees (9-10), 8-3 | Hilltop Park (1-1) | 11-8 | |
| » Starters: Frank Kitson vs Walter Clarkson | Second | 1 out |
| Friday, May 11 |
| » Lost to Tigers (11-8), 4-0 | American League Park II (6-5) | 11-9 | |
| » Starters: George Mullin vs Tom Hughes | Fourth | 2½ out |
| Saturday, May 12 |
| » Lost to Tigers (12-8), 4-0 | American League Park II (6-6) | 11-10 | Lost 2 |
| » Starters: Red Donahue vs Casey Patten | Fifth | 3½ out |
| Monday, May 14 |
| » Lost to Tigers (13-8), 3-1 | American League Park II (6-7) | 11-11 | Lost 3 |
| » Starters: Bill Donovan vs Frank Kitson | Fifth | 4 out |
| Tuesday, May 15 |
| » Defeated Tigers (13-9), 5-0 | American League Park II (7-7) | 12-11 | |
| » Starters: John Eubank vs Cy Falkenberg | Fifth | 4 out |
| Wednesday, May 16 |
| » Lost to White Sox (9-13), 6-5 | American League Park II (7-8) | 12-12 | |
| » Starters: Frank Smith vs Tom Hughes | Fifth | 5 out |
| Thursday, May 17 |
| » Lost to White Sox (10-13), 6-2 | American League Park II (7-9) | 12-13 | Lost 2 |
| » Starters: Roy Patterson vs Charlie Smith | Sixth | 6 out |
| Friday, May 18 |
| » Lost to White Sox (11-13), 10-0 | American League Park II (7-10) | 12-14 | Lost 3 |
| » Starters: Frank Owen vs Casey Patten | Fifth | 7 out |
| Saturday, May 19 |
| » Lost to White Sox (12-13), 3-1 | American League Park II (7-11) | 12-15 | Lost 4 |
| » Starters: Roy Patterson vs Frank Kitson | Seventh | 8 out |
| Monday, May 21 |
| » Defeated Browns (14-15), 9-1 | American League Park II (8-11) | 13-15 | |
| » Starters: Jack Powell vs Cy Falkenberg | Sixth | 7 out |
| Tuesday, May 22 |
| » Lost to Browns (15-15), 6-4 | American League Park II (8-12) | 13-16 | |
| » Starters: Ed Smith vs Willie Sudhoff | Sixth | 7 out |
| Wednesday, May 23 |
| » Lost to Browns (16-15), 10-7 | American League Park II (8-13) | 13-17 | Lost 2 |
| » Starters: Fred Glade vs Charlie Smith | Sixth | 8 out |
| Future Senator Willis Hudlin is born in Wagoner, OK. |
| Thursday, May 24 |
| » Lost to Browns (17-15), 5-3 | American League Park II (8-14) | 13-18 | Lost 3 |
| » Starters: Harry Howell vs Barney Wolfe | Seventh | 8 out |
| Friday, May 25 |
| » Lost to Indians (19-10), 4-0 | American League Park II (8-15) | 13-19 | Lost 4 |
| » Starters: Harry Eells vs Tom Hughes | Seventh | 9 out |
| Saturday, May 26 |
| » Lost to Indians (20-10), 6-4 | American League Park II (8-16) | 13-20 | Lost 5 |
| » Starters: Addie Joss vs Cy Falkenberg | Seventh | 10 out |
| Tuesday, May 29 |
| » Lost to Yankees (20-13), 5-2 | Hilltop Park (1-2) | 13-21 | Lost 6 |
| » Starters: Frank Kitson vs Al Orth | Seventh | 11 out |
| » Major-league debuts: Dave Altizer (Senators) |
| Wednesday, May 30 |
| » Lost to Yankees (21-13), 8-2 | Hilltop Park (1-3) | 13-22 | Lost 7 |
| » Starters: Casey Patten vs Louis LeRoy | Seventh | 11 out |
| » Lost to Yankees (22-13), 7-6 | Hilltop Park (1-4) | 13-23 | Lost 8 |
| » Starters: Tom Hughes vs Bill Hogg | Seventh | 11 out |
| Thursday, May 31 |
| » Defeated Red Sox (10-29), 9-2 | Huntington Ave Baseball Grounds (4-0) | 14-23 | |
| » Starters: Cy Falkenberg vs Jesse Tannehill | Seventh | 10 out |
| Friday, June 1 |
| » Defeated Red Sox (10-30), 4-0 | Huntington Ave Baseball Grounds (5-0) | 15-23 | Won 2 |
| » Starters: Casey Patten vs Joe Harris | Seventh | 10 out |
| » Lost to Red Sox (11-30), 12-8 | Huntington Ave Baseball Grounds (5-1) | 15-24 | |
| » Starters: Willie Sudhoff vs Ralph Glaze | Seventh | 10 out |
| » Major-league debuts: Ralph Glaze (Red Sox) |
| Saturday, June 2 |
| » Lost to Red Sox (12-30), 6-2 | Huntington Ave Baseball Grounds (5-2) | 15-25 | Lost 2 |
| » Starters: Tom Hughes vs Jesse Tannehill | Seventh | 10½ out |
| Monday, June 4 |
| » Lost to Tigers (20-19), 13-4 | Bennett Park (0-1) | 15-26 | Lost 3 |
| » Starters: Cy Falkenberg vs Ed Killian | Seventh | 11½ out |
| Wednesday, June 6 |
| » Lost to Tigers (21-19), 2-1 | Bennett Park (0-2) | 15-27 | Lost 4 |
| » Starters: Frank Kitson vs Ed Siever | Seventh | 11 out |
| Thursday, June 7 |
| » Lost to Tigers (22-19), 7-1 | Bennett Park (0-3) | 15-28 | Lost 5 |
| » Starters: Casey Patten vs Red Donahue | Seventh | 12 out |
| Friday, June 8 |
| » Defeated Indians (25-16), 8-4 | League Park I (1-0) | 16-28 | |
| » Starters: Tom Hughes vs Otto Hess | Seventh | 12 out |
| Saturday, June 9 |
| » Lost to Indians (26-16), 3-1 | League Park I (1-1) | 16-29 | |
| » Starters: Charlie Smith vs Bob Rhoads | Seventh | 13 out |
| Monday, June 11 |
| » Defeated Indians (26-17), 6-4 | League Park I (2-1) | 17-29 | |
| » Starters: Cy Falkenberg vs Addie Joss | Seventh | 12½ out |
| Tuesday, June 12 |
| » Lost to White Sox (21-24), 3-2 | South Side Park III (0-1) | 17-30 | |
| » Starters: Frank Kitson vs Ed Walsh | Seventh | 12½ out |
| Wednesday, June 13 |
| » Lost to White Sox (22-24), 3-0 | South Side Park III (0-2) | 17-31 | Lost 2 |
| » Starters: Tom Hughes vs Frank Smith | Seventh | 13½ out |
| Thursday, June 14 |
| » Lost to White Sox (23-24), 2-0 | South Side Park III (0-3) | 17-32 | Lost 3 |
| » Starters: Casey Patten vs Ed Walsh | Seventh | 13½ out |
| Friday, June 15 |
| » Defeated White Sox (23-25), 10-2 | South Side Park III (1-3) | 18-32 | |
| » Starters: Cy Falkenberg vs Frank Smith | Seventh | 12½ out |
| Future Senator Monte Weaver is born in Helton, NC. |
| Saturday, June 16 |
| » Defeated Browns (26-26), 5-3 | Sportsman's Park II (1-0) | 19-32 | Won 2 |
| » Starters: Willie Sudhoff vs Ed Smith | Seventh | 12½ out |
| Sunday, June 17 |
| » Lost to Browns (27-26), 7-3 | Sportsman's Park II (1-1) | 19-33 | |
| » Starters: Tom Hughes vs Harry Howell | Seventh | 13 out |
| Monday, June 18 |
| » Lost to Browns (28-26), 6-3 | Sportsman's Park II (1-2) | 19-34 | Lost 2 |
| » Starters: Frank Kitson vs Barney Pelty | Seventh | 13 out |
| Tuesday, June 19 |
| » Lost to Browns (29-26), 3-2 | Sportsman's Park II (1-3) | 19-35 | Lost 3 |
| » Starters: Cy Falkenberg vs Fred Glade | Seventh | 13½ out |
| Thursday, June 21 |
| » Tied Athletics, 1-1 | American League Park II (8-16) | 19-35 | |
| » Starters: Chief Bender vs Charlie Smith | Seventh | 14½ out |
| Friday, June 22 |
| » Defeated Yankees (32-24), 2-1 | American League Park II (9-16) | 20-35 | |
| » Starters: Al Orth vs Casey Patten | Seventh | 14½ out |
| Saturday, June 23 |
| » Lost to Yankees (33-24), 3-2 | American League Park II (9-17) | 20-36 | |
| » Starters: Bill Hogg vs Frank Kitson | Seventh | 14½ out |
| Monday, June 25 |
| » Lost to Yankees (34-24), 2-0 | American League Park II (9-18) | 20-37 | Lost 2 |
| » Starters: Jack Chesbro vs Cy Falkenberg | Seventh | 15½ out |
| Future Senator Joe Kuhel is born in Cleveland, OH. |
| Wednesday, June 27 |
| » Lost to Athletics (36-23), 5-0 | American League Park II (9-19) | 20-38 | Lost 3 |
| » Starters: Eddie Plank vs Tom Hughes | Seventh | 15½ out |
| Thursday, June 28 |
| » Defeated Athletics (36-24), 4-2 | American League Park II (10-19) | 21-38 | |
| » Starters: Rube Waddell vs Charlie Smith | Fourth | 14½ out |
| Friday, June 29 |
| » Lost to Athletics (37-24), 9-5 | American League Park II (10-20) | 21-39 | |
| » Starters: Andy Coakley vs Frank Kitson | Sixth | 15 out |
| » Defeated Athletics (37-25), 6-5 | American League Park II (11-20) | 22-39 | |
| » Starters: Jimmy Dygert vs Casey Patten | Sixth | 15 out |
| Saturday, June 30 |
| » Lost to Athletics (38-25), 6-5 | American League Park II (11-21) | 22-40 | |
| » Starters: Rube Waddell vs Tom Hughes | Seventh | 15½ out |
| Monday, July 2 |
| » Lost to Red Sox (17-46), 4-3 | American League Park II (11-22) | 22-41 | Lost 2 |
| » Starters: Cy Young vs Charlie Smith | Sixth | 15½ out |
| » Defeated Red Sox (17-47), 17-3 | American League Park II (12-22) | 23-41 | |
| » Starters: George Winter vs Cy Falkenberg | Sixth | 15½ out |
| Tuesday, July 3 |
| » Defeated Red Sox (17-48), 5-0 | American League Park II (13-22) | 24-41 | Won 2 |
| » Starters: Joe Harris vs Frank Kitson | Seventh | 15½ out |
| Wednesday, July 4 |
| » Defeated Red Sox (17-49), 8-1 | American League Park II (14-22) | 25-41 | Won 3 |
| » Starters: Bill Dinneen vs Casey Patten | Seventh | 16½ out |
| » Lost to Red Sox (18-49), 9-3 | American League Park II (14-23) | 25-42 | |
| » Starters: Cy Young vs Tom Hughes | Seventh | 16½ out |
| Thursday, July 5 |
| » Lost to Athletics (41-27), 3-0 | Columbia Park (1-4) | 25-43 | Lost 2 |
| » Starters: Charlie Smith vs Jack Coombs | Seventh | 16½ out |
| Friday, July 6 |
| » Lost to Athletics (42-27), 2-1 | Columbia Park (1-5) | 25-44 | Lost 3 |
| » Starters: Cy Falkenberg vs Eddie Plank | Sixth | 17½ out |
| Saturday, July 7 |
| » Lost to Tigers (37-34), 9-3 | American League Park II (14-24) | 25-45 | Lost 4 |
| » Starters: Ed Killian vs Frank Kitson | Seventh | 18 out |
| Monday, July 9 |
| » Lost to Tigers (38-34), 7-4 | American League Park II (14-25) | 25-46 | Lost 5 |
| » Starters: George Mullin vs Casey Patten | Sixth | 18½ out |
| Tuesday, July 10 |
| » Lost to Tigers (39-34), 4-3 | American League Park II (14-26) | 25-47 | Lost 6 |
| » Starters: Red Donahue vs Charlie Smith | Sixth | 19 out |
| Future Senator Ad Liska is born in Dwight, NE. |
| Thursday, July 12 |
| » Lost to Indians (44-29), 6-0 | American League Park II (14-27) | 25-48 | Lost 7 |
| » Starters: Otto Hess vs Cy Falkenberg | Sixth | 20 out |
| Friday, July 13 |
| » Defeated Indians (44-30), 8-4 | American League Park II (15-27) | 26-48 | |
| » Starters: Bill Bernhard vs Tom Hughes | Sixth | 19 out |
| Saturday, July 14 |
| » Defeated Indians (44-31), 3-2 | American League Park II (16-27) | 27-48 | Won 2 |
| » Starters: Addie Joss vs Casey Patten | Sixth | 19½ out |
| » Lost to Indians (45-31), 6-4 | American League Park II (16-28) | 27-49 | |
| » Starters: Bob Rhoads vs Charlie Smith | Sixth | 19½ out |
| Monday, July 16 |
| » Lost to Indians (46-31), 5-0 | American League Park II (16-29) | 27-50 | Lost 2 |
| » Starters: Otto Hess vs Tom Hughes | Seventh | 20½ out |
| Wednesday, July 18 |
| » Defeated White Sox (44-35), 6-3 | American League Park II (17-29) | 28-50 | |
| » Starters: Frank Owen vs Cy Falkenberg | Seventh | 20 out |
| Thursday, July 19 |
| » Lost to White Sox (45-35), 6-4 | American League Park II (17-30) | 28-51 | |
| » Starters: Ed Walsh vs Frank Kitson | Seventh | 19½ out |
| » Defeated White Sox (45-36), 3-0 | American League Park II (18-30) | 29-51 | |
| » Starters: Nick Altrock vs Charlie Smith | Seventh | 19½ out |
| Future Senator Jackie Hayes is born in Clanton, AL. |
| Friday, July 20 |
| » Defeated White Sox (45-37), 1-0 | American League Park II (19-30) | 30-51 | Won 2 |
| » Starters: Roy Patterson vs Casey Patten | Seventh | 19½ out |
| Monday, July 23 |
| » Defeated Browns (42-41), 3-2 | American League Park II (20-30) | 31-51 | Won 3 |
| » Starters: Jack Powell vs Cy Falkenberg | Seventh | 19½ out |
| Tuesday, July 24 |
| » Defeated Browns (42-42), 3-2 | American League Park II (21-30) | 32-51 | Won 4 |
| » Starters: Harry Howell vs Charlie Smith | Seventh | 19½ out |
| Wednesday, July 25 |
| » Defeated Browns (42-43), 2-0 | American League Park II (22-30) | 33-51 | Won 5 |
| » Starters: Fred Glade vs Casey Patten | Seventh | 20 out |
| Thursday, July 26 |
| » Lost to Indians (50-36), 13-4 | League Park I (2-2) | 33-52 | |
| » Starters: Tom Hughes vs Otto Hess | Seventh | 20½ out |
| Friday, July 27 |
| » Lost to White Sox (47-42), 3-1 | South Side Park III (1-4) | 33-53 | Lost 2 |
| » Starters: Cy Falkenberg vs Roy Patterson | Seventh | 21 out |
| Sunday, July 29 |
| » Lost to White Sox (48-42), 5-3 | South Side Park III (1-5) | 33-54 | Lost 3 |
| » Starters: Charlie Smith vs Ed Walsh | Seventh | 22 out |
| Monday, July 30 |
| » Lost to White Sox (49-42), 4-1 | South Side Park III (1-6) | 33-55 | Lost 4 |
| » Starters: Casey Patten vs Frank Owen | Seventh | 23 out |
| Tuesday, July 31 |
| » Lost to White Sox (50-42), 4-3 | South Side Park III (1-7) | 33-56 | Lost 5 |
| » Starters: Frank Kitson vs Roy Patterson | Seventh | 23 out |
| Wednesday, August 1 |
| » Lost to Browns (46-45), 3-2 | Sportsman's Park II (1-4) | 33-57 | Lost 6 |
| » Starters: Cy Falkenberg vs Barney Pelty | Seventh | 23 out |
| Thursday, August 2 |
| » Lost to Browns (47-45), 11-2 | Sportsman's Park II (1-5) | 33-58 | Lost 7 |
| » Starters: Charlie Smith vs Harry Howell | Sixth | 24 out |
| Friday, August 3 |
| » Defeated Browns (47-46), 1-0 | Sportsman's Park II (2-5) | 34-58 | |
| » Starters: Tom Hughes vs Fred Glade | Seventh | 24 out |
| Saturday, August 4 |
| » Defeated Browns (47-47), 2-0 | Sportsman's Park II (3-5) | 35-58 | Won 2 |
| » Starters: Casey Patten vs Jack Powell | Seventh | 24 out |
| Monday, August 6 |
| » Defeated Tigers (48-47), 5-4 | Bennett Park (1-3) | 36-58 | Won 3 |
| » Starters: Cy Falkenberg vs Red Donahue | Seventh | 22½ out |
| Tuesday, August 7 |
| » Defeated Tigers (48-48), 6-5 | Bennett Park (2-3) | 37-58 | Won 4 |
| » Starters: Tom Hughes vs John Eubank | Sixth | 21½ out |
| Wednesday, August 8 |
| » Defeated Tigers (48-49), 6-0 | Bennett Park (3-3) | 38-58 | Won 5 |
| » Starters: Casey Patten vs George Mullin | Seventh | 20 out |
| » Defeated Tigers (48-50), 7-4 | Bennett Park (4-3) | 39-58 | Won 6 |
| » Starters: Charlie Smith vs Bill Donovan | Seventh | 20 out |
| Thursday, August 9 |
| » Lost to Tigers (49-50), 8-5 | Bennett Park (4-4) | 39-59 | |
| » Starters: Cy Falkenberg vs Ed Siever | Seventh | 20 out |
| Saturday, August 11 |
| » Lost to Indians (54-43), 3-1 | League Park I (2-3) | 39-60 | Lost 2 |
| » Starters: Casey Patten vs Otto Hess | Seventh | 19½ out |
| Monday, August 13 |
| » Lost to Indians (55-43), 3-1 | League Park I (2-4) | 39-61 | Lost 3 |
| » Starters: Cy Falkenberg vs Earl Moore | Seventh | 20 out |
| Tuesday, August 14 |
| » Lost to Indians (56-43), 9-8 | League Park I (2-5) | 39-62 | Lost 4 |
| » Starters: Cy Falkenberg vs Addie Joss | Seventh | 20½ out |
| Wednesday, August 15 |
| » Defeated Browns (53-50), 4-2 | American League Park II (23-30) | 40-62 | |
| » Starters: Barney Pelty vs Casey Patten | Seventh | 20½ out |
| Thursday, August 16 |
| » Lost to Browns (54-50), 6-1 | American League Park II (23-31) | 40-63 | |
| » Starters: Fred Glade vs Charlie Smith | Seventh | 21½ out |
| Friday, August 17 |
| » Defeated Browns (54-51), 3-2 | American League Park II (24-31) | 41-63 | |
| » Starters: Jack Powell vs Tom Hughes | Seventh | 22 out |
| » Lost to Browns (55-51), 4-3 | American League Park II (24-32) | 41-64 | |
| » Starters: Harry Howell vs Frank Kitson | Seventh | 22 out |
| Saturday, August 18 |
| » Lost to Indians (59-45), 4-2 | American League Park II (24-33) | 41-65 | Lost 2 |
| » Starters: Bill Bernhard vs Cy Falkenberg | Seventh | 23 out |
| Tuesday, August 21 |
| » Lost to Indians (60-45), 2-0 | American League Park II (24-34) | 41-66 | Lost 3 |
| » Starters: Bob Rhoads vs Tom Hughes | Seventh | 23½ out |
| » Defeated Indians (60-46), 2-1 | American League Park II (25-34) | 42-66 | |
| » Starters: Otto Hess vs Casey Patten | Seventh | 23½ out |
| Wednesday, August 22 |
| » Defeated Indians (60-47), 4-0 | American League Park II (26-34) | 43-66 | Won 2 |
| » Starters: Bill Bernhard vs Charlie Smith | Seventh | 24 out |
| Thursday, August 23 |
| » Lost to White Sox (69-43), 4-1 | American League Park II (26-35) | 43-67 | |
| » Starters: Roy Patterson vs Cy Falkenberg | Seventh | 25 out |
| Saturday, August 25 |
| » Defeated White Sox (69-44), 5-4 | American League Park II (27-35) | 44-67 | |
| » Starters: Frank Smith vs Tom Hughes | Seventh | 23 out |
| » Defeated White Sox (69-45), 4-3 | American League Park II (28-35) | 45-67 | Won 2 |
| » Starters: Roy Patterson vs Casey Patten | Seventh | 23 out |
| Monday, August 27 |
| » Defeated Tigers (54-59), 10-1 | American League Park II (29-35) | 46-67 | Won 3 |
| » Starters: Red Donahue vs Cy Falkenberg | Seventh | 23 out |
| Thursday, August 30 |
| » Lost to Yankees (64-48), 5-0 | Hilltop Park (1-5) | 46-68 | |
| » Starters: Casey Patten vs Slow Joe Doyle | Seventh | 23½ out |
| » Lost to Yankees (65-48), 9-8 | Hilltop Park (1-6) | 46-69 | Lost 2 |
| » Starters: Frank Kitson vs Cy Barger | Seventh | 23½ out |
| » Major-league debuts: Cy Barger (Yankees) |
| Friday, August 31 |
| » Lost to Yankees (66-48), 7-5 | Hilltop Park (1-7) | 46-70 | Lost 3 |
| » Starters: Cy Falkenberg vs Jack Chesbro | Seventh | 25 out |
| » Lost to Yankees (67-48), 20-5 | Hilltop Park (1-8) | 46-71 | Lost 4 |
| » Starters: Harry Hardy vs Al Orth | Seventh | 25 out |
| Saturday, September 1 |
| » Lost to Yankees (68-48), 5-4 | Hilltop Park (1-9) | 46-72 | Lost 5 |
| » Starters: Charlie Smith vs Walter Clarkson | Seventh | 25½ out |
| » Lost to Yankees (69-48), 5-3 | Hilltop Park (1-10) | 46-73 | Lost 6 |
| » Starters: Casey Patten vs Al Orth | Seventh | 25½ out |
| Monday, September 3 |
| » Lost to Red Sox (39-82), 3-1 | Huntington Ave Baseball Grounds (5-3) | 46-74 | Lost 7 |
| » Starters: Cy Falkenberg vs Cy Young | Seventh | 25 out |
| » Defeated Red Sox (39-83), 6-3 | Huntington Ave Baseball Grounds (6-3) | 47-74 | |
| » Starters: Casey Patten vs George Winter | Seventh | 25 out |
| Tuesday, September 4 |
| » Lost to Athletics (67-52), 10-3 | American League Park II (29-36) | 47-75 | |
| » Starters: Chief Bender vs Charlie Smith | Seventh | 26 out |
| Wednesday, September 5 |
| » Lost to Athletics (68-52), 3-1 | American League Park II (29-37) | 47-76 | Lost 2 |
| » Starters: Jack Coombs vs Tom Hughes | Seventh | 27 out |
| Thursday, September 6 |
| » Defeated Athletics (68-53), 4-0 | American League Park II (30-37) | 48-76 | |
| » Starters: Jimmy Dygert vs Cy Falkenberg | Seventh | 27 out |
| Friday, September 7 |
| » Lost to Red Sox (40-87), 4-1 | Huntington Ave Baseball Grounds (6-4) | 48-77 | |
| » Starters: Casey Patten vs Jesse Tannehill | Seventh | 28 out |
| Saturday, September 8 |
| » Defeated Red Sox (40-88), 5-2 | Huntington Ave Baseball Grounds (7-4) | 49-77 | |
| » Starters: Frank Kitson vs Ralph Glaze | Seventh | 28 out |
| Monday, September 10 |
| » Lost to Athletics (69-55), 2-1 | Columbia Park (1-6) | 49-78 | |
| » Starters: Cy Falkenberg vs Jack Coombs | Seventh | 28 out |
| Tuesday, September 11 |
| » Lost to Athletics (70-55), 4-1 | Columbia Park (1-7) | 49-79 | Lost 2 |
| » Starters: Frank Kitson vs Rube Waddell | Seventh | 29 out |
| Wednesday, September 12 |
| » Lost to Athletics (71-55), 5-1 | Columbia Park (1-8) | 49-80 | Lost 3 |
| » Starters: Casey Patten vs Mike Cunningham | Seventh | 29 out |
| Thursday, September 13 |
| » Lost to Yankees (78-50), 4-2 | American League Park II (30-38) | 49-81 | Lost 4 |
| » Starters: Jack Chesbro vs Cy Falkenberg | Seventh | 30 out |
| Friday, September 14 |
| » Defeated Yankees (78-51), 5-1 | American League Park II (31-38) | 50-81 | |
| » Starters: Slow Joe Doyle vs Frank Kitson | Seventh | 29½ out |
| Saturday, September 15 |
| » Defeated Yankees (78-52), 3-1 | American League Park II (32-38) | 51-81 | Won 2 |
| » Starters: Walter Clarkson vs Casey Patten | Seventh | 30 out |
| » Lost to Yankees (79-52), 6-1 | American League Park II (32-39) | 51-82 | |
| » Starters: Al Orth vs Bob Edmundson | Seventh | 30 out |
| Monday, September 17 |
| » Defeated Indians (73-58), 4-2 | League Park I (3-5) | 52-82 | |
| » Starters: Cy Falkenberg vs Bob Rhoads | Seventh | 30½ out |
| Tuesday, September 18 |
| » Lost to Indians (74-58), 8-5 | League Park I (3-6) | 52-83 | |
| » Starters: Frank Kitson vs Addie Joss | Seventh | 32 out |
| » Lost to Indians (75-58), 7-2 | League Park I (3-7) | 52-84 | Lost 2 |
| » Starters: Charlie Smith vs Otto Hess | Seventh | 32 out |
| Wednesday, September 19 |
| » Lost to Indians (76-58), 3-1 | League Park I (3-8) | 52-85 | Lost 3 |
| » Starters: Harry Hardy vs Bill Bernhard | Seventh | 32 out |
| Thursday, September 20 |
| » Lost to Tigers (62-73), 7-0 | Bennett Park (4-5) | 52-86 | Lost 4 |
| » Starters: Casey Patten vs Red Donahue | Seventh | 32½ out |
| Friday, September 21 |
| » Lost to Tigers (63-73), 5-4 | Bennett Park (4-6) | 52-87 | Lost 5 |
| » Starters: Charlie Smith vs Ed Siever | Seventh | 32½ out |
| Saturday, September 22 |
| » Lost to Tigers (64-73), 5-3 | Bennett Park (4-7) | 52-88 | Lost 6 |
| » Starters: Cy Falkenberg vs George Mullin | Seventh | 33½ out |
| » Lost to Tigers (65-73), 4-3 | Bennett Park (4-8) | 52-89 | Lost 7 |
| » Starters: Clyde Goodwin vs George Mullin | Seventh | 33½ out |
| Monday, September 24 |
| » Defeated Browns (70-69), 2-0 | Sportsman's Park II (4-5) | 53-89 | |
| » Starters: Casey Patten vs Barney Pelty | Seventh | 33 out |
| Tuesday, September 25 |
| » Lost to Browns (71-69), 5-4 | Sportsman's Park II (4-6) | 53-90 | |
| » Starters: Charlie Smith vs Fred Glade | Seventh | 34 out |
| Wednesday, September 26 |
| » Lost to Browns (72-69), 5-1 | Sportsman's Park II (4-7) | 53-91 | Lost 2 |
| » Starters: Harry Hardy vs Jack Powell | Seventh | 35 out |
| Thursday, September 27 |
| » Lost to White Sox (88-55), 4-2 | South Side Park III (1-8) | 53-92 | Lost 3 |
| » Starters: Casey Patten vs Frank Owen | Seventh | 36 out |
| Sunday, September 30 |
| » Lost to White Sox (89-55), 8-5 | South Side Park III (1-9) | 53-93 | Lost 4 |
| » Starters: Clyde Goodwin vs Frank Owen | Seventh | 36 out |
| » Defeated White Sox (89-56), 3-0 | South Side Park III (2-9) | 54-93 | |
| » Starters: Casey Patten vs Ed Walsh | Seventh | 36 out |
| » Major-league debuts: Lee Quillen (White Sox) |
| Tuesday, October 2 |
| » Lost to Red Sox (48-102), 6-5 | American League Park II (32-40) | 54-94 | |
| » Starters: Frank Oberlin vs Clyde Goodwin | Seventh | 37½ out |
| Wednesday, October 3 |
| » Defeated Red Sox (48-103), 2-1 | American League Park II (33-40) | 55-94 | |
| » Starters: Joe Harris vs Cy Falkenberg | Seventh | 37½ out |
| » Lost to Red Sox (49-103), 2-1 | American League Park II (33-41) | 55-95 | |
| » Starters: Len Swormstedt vs Willy Wilson | Seventh | 37½ out |
| Friday, October 12 |
| Future Senator Joe Cronin is born in San Francisco, CA. |
| Wednesday, November 7 |
| Future Senator Alan Strange is born in Philadelphia, PA. |
| Tuesday, December 18 |
| Future Senator Dick Coffman is born in Veto, AL. |
| Sunday, December 30 |
| Future Senator Ray Prim is born in Salitpa, AL. |
Game information provided by Retrosheet (www.retrosheet.org) |