| Thursday, April 12 |
| » Major-league debuts: Pug Bennett (Cardinals) |
| Saturday, April 14 |
| » Defeated Senators (0-1), 4-3 | American League Park II (1-0) | 1-0 | |
| » Starters: Chief Bender vs Tom Hughes | First | -- |
| » Major-league debuts: Art Brouthers (Athletics) |
| Sunday, April 15 |
| » Major-league debuts: Ed Karger (Pirates) |
| Monday, April 16 |
| » Defeated Senators (0-2), 5-3 | American League Park II (2-0) | 2-0 | Won 2 |
| » Starters: Jimmy Dygert vs Willie Sudhoff | First | -- |
| Tuesday, April 17 |
| » Lost to Senators (1-2), 5-2 | American League Park II (2-1) | 2-1 | |
| » Starters: Jimmy Dygert vs Cy Falkenberg | Third | 1 out |
| Wednesday, April 18 |
| » Defeated Senators (1-3), 4-2 | Columbia Park (1-0) | 3-1 | |
| » Starters: Barney Wolfe vs Chief Bender | Third | ½ out |
| Thursday, April 19 |
| » Lost to Senators (2-3), 11-10 | Columbia Park (1-1) | 3-2 | |
| » Starters: Willie Sudhoff vs Eddie Plank | Third | 1 out |
| » Major-league debuts: Jack Hannifin (Athletics) |
| Friday, April 20 |
| » Defeated Yankees (3-3), 11-3 | Columbia Park (2-1) | 4-2 | |
| » Starters: Al Orth vs Andy Coakley | Second | 1½ out |
| Saturday, April 21 |
| » Defeated Yankees (3-4), 3-1 | Columbia Park (3-1) | 5-2 | Won 2 |
| » Starters: Bill Hogg vs Rube Waddell | Second | 1½ out |
| Tuesday, April 24 |
| » Lost to Yankees (4-4), 7-4 | Columbia Park (3-2) | 5-3 | |
| » Starters: Walter Clarkson vs Chief Bender | First | -- |
| Wednesday, April 25 |
| » Defeated Red Sox (3-6), 5-0 | Columbia Park (4-2) | 6-3 | |
| » Starters: Cy Young vs Rube Waddell | First | -- |
| Thursday, April 26 |
| » Lost to Red Sox (4-6), 12-0 | Columbia Park (4-3) | 6-4 | |
| » Starters: George Winter vs Andy Coakley | First | -- |
| Friday, April 27 |
| » Defeated Red Sox (4-7), 3-0 | Columbia Park (5-3) | 7-4 | |
| » Starters: Cy Young vs Eddie Plank | First | -- |
| Saturday, April 28 |
| » Lost to Red Sox (5-7), 7-6 | Columbia Park (5-4) | 7-5 | |
| » Starters: Bill Dinneen vs Rube Waddell | First | -- |
| Monday, April 30 |
| » Defeated Senators (7-6), 6-3 | Columbia Park (6-4) | 8-5 | |
| » Starters: Cy Falkenberg vs Chief Bender | First | -- |
| Tuesday, May 1 |
| » Defeated Senators (7-7), 16-2 | Columbia Park (7-4) | 9-5 | Won 2 |
| » Starters: Tom Hughes vs Eddie Plank | First | -- |
| Thursday, May 3 |
| » Lost to Yankees (7-8), 6-5 | Hilltop Park (0-1) | 9-6 | |
| » Starters: Jimmy Dygert vs Walter Clarkson | First | -- |
| Friday, May 4 |
| » Lost to Yankees (8-8), 6-2 | Hilltop Park (0-2) | 9-7 | Lost 2 |
| » Starters: Chief Bender vs Louis LeRoy | Third | ½ out |
| Saturday, May 5 |
| » Defeated Yankees (8-9), 9-3 | Hilltop Park (1-2) | 10-7 | |
| » Starters: Chief Bender vs Bill Hogg | First | -- |
| Monday, May 7 |
| » Defeated Red Sox (6-12), 4-0 | Huntington Ave Baseball Grounds (1-0) | 11-7 | Won 2 |
| » Starters: Rube Waddell vs George Winter | First | -- |
| Tuesday, May 8 |
| » Defeated Red Sox (6-13), 11-4 | Huntington Ave Baseball Grounds (2-0) | 12-7 | Won 3 |
| » Starters: Andy Coakley vs Jesse Tannehill | First | -- |
| Wednesday, May 9 |
| » Defeated Red Sox (6-14), 9-6 | Huntington Ave Baseball Grounds (3-0) | 13-7 | Won 4 |
| » Starters: Eddie Plank vs Cy Young | First | -- |
| Thursday, May 10 |
| » Defeated Red Sox (6-15), 5-1 | Huntington Ave Baseball Grounds (4-0) | 14-7 | Won 5 |
| » Starters: Chief Bender vs Joe Harris | First | -- |
| Saturday, May 12 |
| » Defeated White Sox (8-12), 4-0 | Columbia Park (8-4) | 15-7 | Won 6 |
| » Starters: Frank Owen vs Rube Waddell | First | -- |
| Tuesday, May 15 |
| » Defeated White Sox (8-13), 1-0 | Columbia Park (9-4) | 16-7 | Won 7 |
| » Starters: Nick Altrock vs Eddie Plank | First | -- |
| Wednesday, May 16 |
| » Defeated Tigers (13-10), 9-2 | Columbia Park (10-4) | 17-7 | Won 8 |
| » Starters: George Mullin vs Chief Bender | First | -- |
| Thursday, May 17 |
| » Defeated Tigers (13-11), 5-0 | Columbia Park (11-4) | 18-7 | Won 9 |
| » Starters: Ed Siever vs Rube Waddell | First | -- |
| Friday, May 18 |
| » Defeated Tigers (13-12), 4-3 | Columbia Park (12-4) | 19-7 | Won 10 |
| » Starters: Red Donahue vs Eddie Plank | First | -- |
| Saturday, May 19 |
| » Defeated Tigers (13-13), 2-1 | Columbia Park (13-4) | 20-7 | Won 11 |
| » Starters: Bill Donovan vs Andy Coakley | First | -- |
| Monday, May 21 |
| » Lost to Indians (16-9), 2-1 | Columbia Park (13-5) | 20-8 | |
| » Starters: Harry Eells vs Rube Waddell | First | -- |
| Tuesday, May 22 |
| » Lost to Indians (17-9), 8-5 | Columbia Park (13-6) | 20-9 | Lost 2 |
| » Starters: Addie Joss vs Chief Bender | First | -- |
| Wednesday, May 23 |
| » Defeated Indians (17-10), 4-3 | Columbia Park (14-6) | 21-9 | |
| » Starters: Otto Hess vs Eddie Plank | First | -- |
| Thursday, May 24 |
| » Lost to Indians (18-10), 9-7 | Columbia Park (14-7) | 21-10 | |
| » Starters: Bill Bernhard vs Andy Coakley | First | -- |
| Friday, May 25 |
| » Defeated Browns (17-16), 6-2 | Columbia Park (15-7) | 22-10 | |
| » Starters: Beany Jacobson vs Jimmy Dygert | First | -- |
| Saturday, May 26 |
| » Defeated Browns (17-17), 3-2 | Columbia Park (16-7) | 23-10 | Won 2 |
| » Starters: Ed Smith vs Chief Bender | First | -- |
| Tuesday, May 29 |
| » Defeated Red Sox (8-28), 2-1 | Huntington Ave Baseball Grounds (5-0) | 24-10 | Won 3 |
| » Starters: Eddie Plank vs Joe Harris | First | -- |
| Wednesday, May 30 |
| » Lost to Red Sox (9-28), 5-1 | Huntington Ave Baseball Grounds (5-1) | 24-11 | |
| » Starters: Andy Coakley vs Bill Dinneen | First | -- |
| » Lost to Red Sox (10-28), 5-3 | Huntington Ave Baseball Grounds (5-2) | 24-12 | Lost 2 |
| » Starters: Chief Bender vs George Winter | First | -- |
| Thursday, May 31 |
| » Lost to Yankees (23-13), 7-3 | Hilltop Park (1-3) | 24-13 | Lost 3 |
| » Starters: Jimmy Dygert vs Clark Griffith | First | -- |
| Friday, June 1 |
| » Lost to Yankees (24-13), 10-2 | Hilltop Park (1-4) | 24-14 | Lost 4 |
| » Starters: Andy Coakley vs Jack Chesbro | Second | ½ out |
| Saturday, June 2 |
| » Lost to Yankees (25-13), 14-4 | Hilltop Park (1-5) | 24-15 | Lost 5 |
| » Starters: Chief Bender vs Bill Hogg | Second | ½ out |
| » Defeated Yankees (25-14), 7-1 | Hilltop Park (2-5) | 25-15 | |
| » Starters: Eddie Plank vs Al Orth | Second | ½ out |
| Monday, June 4 |
| » Lost to White Sox (17-21), 3-2 | South Side Park III (0-1) | 25-16 | |
| » Starters: Eddie Plank vs Roy Patterson | Second | 1½ out |
| Tuesday, June 5 |
| » Lost to White Sox (18-21), 7-1 | South Side Park III (0-2) | 25-17 | Lost 2 |
| » Starters: Rube Waddell vs Doc White | Third | 1½ out |
| Wednesday, June 6 |
| » Lost to White Sox (19-21), 4-3 | South Side Park III (0-3) | 25-18 | Lost 3 |
| » Starters: Chief Bender vs Frank Owen | Third | 1½ out |
| Saturday, June 9 |
| » Defeated Browns (24-22), 2-0 | Sportsman's Park II (1-0) | 26-18 | |
| » Starters: Eddie Plank vs Fred Glade | Third | 2½ out |
| Sunday, June 10 |
| » Defeated Browns (24-23), 5-2 | Sportsman's Park II (2-0) | 27-18 | Won 2 |
| » Starters: Andy Coakley vs Ed Smith | Third | 1½ out |
| Monday, June 11 |
| » Defeated Browns (24-24), 5-1 | Sportsman's Park II (3-0) | 28-18 | Won 3 |
| » Starters: Jimmy Dygert vs Harry Howell | Second | 1½ out |
| Tuesday, June 12 |
| » Lost to Tigers (25-20), 8-7 | Bennett Park (0-1) | 28-19 | |
| » Starters: Chief Bender vs Ed Killian | Third | 1½ out |
| Wednesday, June 13 |
| » Defeated Tigers (25-21), 5-4 | Bennett Park (1-1) | 29-19 | |
| » Starters: Eddie Plank vs George Mullin | Second | 1½ out |
| Thursday, June 14 |
| » Lost to Tigers (26-21), 5-4 | Bennett Park (1-2) | 29-20 | |
| » Starters: Andy Coakley vs Red Donahue | Third | 1½ out |
| Friday, June 15 |
| » Defeated Tigers (26-22), 4-0 | Bennett Park (2-2) | 30-20 | |
| » Starters: Jimmy Dygert vs Bill Donovan | Third | 1½ out |
| Saturday, June 16 |
| » Lost to Indians (30-18), 9-4 | League Park I (0-1) | 30-21 | |
| » Starters: Chief Bender vs Bob Rhoads | Third | 1½ out |
| Monday, June 18 |
| » Defeated Indians (30-19), 3-2 | League Park I (1-1) | 31-21 | |
| » Starters: Eddie Plank vs Otto Hess | Third | 1½ out |
| Tuesday, June 19 |
| » Defeated Indians (30-20), 2-0 | League Park I (2-1) | 32-21 | Won 2 |
| » Starters: Rube Waddell vs Addie Joss | First | -- |
| Wednesday, June 20 |
| » Lost to Indians (31-20), 7-3 | League Park I (2-2) | 32-22 | |
| » Starters: Jimmy Dygert vs Bob Rhoads | Second | 1½ out |
| Thursday, June 21 |
| » Tied Senators, 1-1 | American League Park II (2-1) | 32-22 | |
| » Starters: Chief Bender vs Charlie Smith | Second | 1½ out |
| Friday, June 22 |
| » Lost to Red Sox (16-40), 6-4 | Columbia Park (16-8) | 32-23 | Lost 2 |
| » Starters: George Winter vs Andy Coakley | Second | 2½ out |
| Saturday, June 23 |
| » Defeated Red Sox (16-41), 8-0 | Columbia Park (17-8) | 33-23 | |
| » Starters: Joe Harris vs Eddie Plank | Second | 1½ out |
| Monday, June 25 |
| » Defeated Red Sox (16-42), 1-0 | Columbia Park (18-8) | 34-23 | Won 2 |
| » Starters: Bill Dinneen vs Rube Waddell | Second | 1½ out |
| Tuesday, June 26 |
| » Defeated Red Sox (16-43), 3-1 | Columbia Park (19-8) | 35-23 | Won 3 |
| » Starters: Cy Young vs Chief Bender | Second | ½ out |
| Wednesday, June 27 |
| » Defeated Senators (20-38), 5-0 | American League Park II (3-1) | 36-23 | Won 4 |
| » Starters: Eddie Plank vs Tom Hughes | First | -- |
| Thursday, June 28 |
| » Lost to Senators (21-38), 4-2 | American League Park II (3-2) | 36-24 | |
| » Starters: Rube Waddell vs Charlie Smith | First | -- |
| Friday, June 29 |
| » Defeated Senators (21-39), 9-5 | American League Park II (4-2) | 37-24 | |
| » Starters: Andy Coakley vs Frank Kitson | Second | ½ out |
| » Lost to Senators (22-39), 6-5 | American League Park II (4-3) | 37-25 | |
| » Starters: Jimmy Dygert vs Casey Patten | Second | ½ out |
| Saturday, June 30 |
| » Defeated Senators (22-40), 6-5 | American League Park II (5-3) | 38-25 | |
| » Starters: Rube Waddell vs Tom Hughes | Second | 1 out |
| Monday, July 2 |
| » Defeated Yankees (37-25), 5-4 | Columbia Park (20-8) | 39-25 | Won 2 |
| » Starters: Doc Newton vs Eddie Plank | Second | 1 out |
| » Lost to Yankees (38-25), 5-1 | Columbia Park (20-9) | 39-26 | |
| » Starters: Al Orth vs Andy Coakley | Second | 1 out |
| Wednesday, July 4 |
| » Defeated Yankees (38-26), 3-1 | Columbia Park (21-9) | 40-26 | |
| » Starters: Jack Chesbro vs Rube Waddell | Third | 1½ out |
| » Lost to Yankees (39-26), 2-1 | Columbia Park (21-10) | 40-27 | |
| » Starters: Al Orth vs Chief Bender | Third | 1½ out |
| Thursday, July 5 |
| » Defeated Senators (25-43), 3-0 | Columbia Park (22-10) | 41-27 | |
| » Starters: Charlie Smith vs Jack Coombs | Third | ½ out |
| Friday, July 6 |
| » Defeated Senators (25-44), 2-1 | Columbia Park (23-10) | 42-27 | Won 2 |
| » Starters: Cy Falkenberg vs Eddie Plank | Second | ½ out |
| Saturday, July 7 |
| » Defeated Indians (42-28), 3-2 | Columbia Park (24-10) | 43-27 | Won 3 |
| » Starters: Bill Bernhard vs Rube Waddell | First | -- |
| Monday, July 9 |
| » Lost to Indians (43-28), 6-0 | Columbia Park (24-11) | 43-28 | |
| » Starters: Bob Rhoads vs Andy Coakley | Second | ½ out |
| Wednesday, July 11 |
| » Defeated Indians (43-29), 5-1 | Columbia Park (25-11) | 44-28 | |
| » Starters: Happy Townsend vs Rube Waddell | First | -- |
| Thursday, July 12 |
| » Defeated Tigers (39-35), 2-1 | Columbia Park (26-11) | 45-28 | Won 2 |
| » Starters: Bill Donovan vs Eddie Plank | First | -- |
| Friday, July 13 |
| » Lost to Tigers (40-35), 4-3 | Columbia Park (26-12) | 45-29 | |
| » Starters: John Eubank vs Jack Coombs | First | -- |
| Saturday, July 14 |
| » Defeated Tigers (40-36), 5-4 | Columbia Park (27-12) | 46-29 | |
| » Starters: George Mullin vs Rube Waddell | First | -- |
| Monday, July 16 |
| » Defeated Tigers (40-37), 2-1 | Columbia Park (28-12) | 47-29 | Won 2 |
| » Starters: Red Donahue vs Jimmy Dygert | First | -- |
| Wednesday, July 18 |
| » Lost to Browns (41-38), 4-2 | Columbia Park (28-13) | 47-30 | |
| » Starters: Jack Powell vs Eddie Plank | First | -- |
| » Defeated Browns (41-39), 10-5 | Columbia Park (29-13) | 48-30 | |
| » Starters: Ed Smith vs Jack Coombs | First | -- |
| Thursday, July 19 |
| » Lost to Browns (42-39), 4-0 | Columbia Park (29-14) | 48-31 | |
| » Starters: Harry Howell vs Rube Waddell | First | -- |
| Friday, July 20 |
| » Defeated Browns (42-40), 5-2 | Columbia Park (30-14) | 49-31 | |
| » Starters: Fred Glade vs Chief Bender | First | -- |
| Saturday, July 21 |
| » Defeated White Sox (45-38), 3-2 | Columbia Park (31-14) | 50-31 | Won 2 |
| » Starters: Doc White vs Eddie Plank | First | -- |
| Monday, July 23 |
| » Lost to White Sox (46-38), 4-0 | Columbia Park (31-15) | 50-32 | |
| » Starters: Frank Owen vs Jack Coombs | First | -- |
| » Defeated White Sox (46-39), 5-0 | Columbia Park (32-15) | 51-32 | |
| » Starters: Nick Altrock vs Jimmy Dygert | First | -- |
| Tuesday, July 24 |
| » Defeated White Sox (46-40), 7-1 | Columbia Park (33-15) | 52-32 | Won 2 |
| » Starters: Roy Patterson vs Chief Bender | First | -- |
| Wednesday, July 25 |
| » Defeated White Sox (46-41), 5-1 | Columbia Park (34-15) | 53-32 | Won 3 |
| » Starters: Doc White vs Eddie Plank | First | -- |
| » Defeated White Sox (46-42), 4-2 | Columbia Park (35-15) | 54-32 | Won 4 |
| » Starters: Frank Owen vs Rube Waddell | First | -- |
| Saturday, July 28 |
| » Defeated Tigers (45-43), 8-2 | Bennett Park (3-2) | 55-32 | Won 5 |
| » Starters: Chief Bender vs Bill Donovan | First | -- |
| Monday, July 30 |
| » Defeated Tigers (45-44), 6-3 | Bennett Park (4-2) | 56-32 | Won 6 |
| » Starters: Eddie Plank vs Ed Siever | First | -- |
| Tuesday, July 31 |
| » Lost to Tigers (46-44), 5-3 | Bennett Park (4-3) | 56-33 | |
| » Starters: Jimmy Dygert vs George Mullin | First | -- |
| Wednesday, August 1 |
| » Lost to Indians (52-38), 8-3 | League Park I (2-3) | 56-34 | Lost 2 |
| » Starters: Chief Bender vs Harry Eells | First | -- |
| Thursday, August 2 |
| » Defeated Indians (52-39), 3-2 | League Park I (3-3) | 57-34 | |
| » Starters: Jack Coombs vs Bill Bernhard | First | -- |
| Friday, August 3 |
| » Defeated Indians (52-40), 10-7 | League Park I (4-3) | 58-34 | Won 2 |
| » Starters: Eddie Plank vs Bob Rhoads | First | -- |
| Saturday, August 4 |
| » Defeated Indians (52-41), 8-1 | League Park I (5-3) | 59-34 | Won 3 |
| » Starters: Jimmy Dygert vs Otto Hess | First | -- |
| Sunday, August 5 |
| » Lost to White Sox (54-43), 10-2 | South Side Park III (0-4) | 59-35 | |
| » Starters: Chief Bender vs Doc White | First | -- |
| Monday, August 6 |
| » Lost to White Sox (55-43), 7-2 | South Side Park III (0-5) | 59-36 | Lost 2 |
| » Starters: Jack Coombs vs Frank Owen | First | -- |
| Tuesday, August 7 |
| » Lost to White Sox (56-43), 4-0 | South Side Park III (0-6) | 59-37 | Lost 3 |
| » Starters: Rube Waddell vs Ed Walsh | First | -- |
| Wednesday, August 8 |
| » Lost to White Sox (57-43), 1-0 | South Side Park III (0-7) | 59-38 | Lost 4 |
| » Starters: Eddie Plank vs Roy Patterson | First | -- |
| » Major-league debuts: Ed Lennox (Athletics) |
| Thursday, August 9 |
| » Lost to White Sox (58-43), 3-2 | South Side Park III (0-8) | 59-39 | Lost 5 |
| » Starters: Jimmy Dygert vs Doc White | First | -- |
| Friday, August 10 |
| » Lost to Browns (50-48), 1-0 | Sportsman's Park II (3-1) | 59-40 | Lost 6 |
| » Starters: Rube Waddell vs Jack Powell | First | -- |
| Saturday, August 11 |
| » Lost to Browns (51-48), 5-4 | Sportsman's Park II (3-2) | 59-41 | Lost 7 |
| » Starters: Andy Coakley vs Barney Pelty | First | -- |
| Sunday, August 12 |
| » Lost to Browns (52-48), 7-4 | Sportsman's Park II (3-3) | 59-42 | Lost 8 |
| » Starters: Chief Bender vs Fred Glade | Second | 1½ out |
| Monday, August 13 |
| » Defeated Browns (52-49), 8-0 | Sportsman's Park II (4-3) | 60-42 | |
| » Starters: Rube Waddell vs Jack Powell | Second | ½ out |
| » Lost to Browns (53-49), 5-1 | Sportsman's Park II (4-4) | 60-43 | |
| » Starters: Rube Waddell vs Harry Howell | Second | ½ out |
| Wednesday, August 15 |
| » Tied Indians, 3-3 | Columbia Park (35-15) | 60-43 | |
| » Starters: Bob Rhoads vs Jimmy Dygert | Third | 1 out |
| Thursday, August 16 |
| » Lost to Indians (57-43), 4-1 | Columbia Park (35-16) | 60-44 | Lost 2 |
| » Starters: Otto Hess vs Rube Waddell | Second | 1½ out |
| » Defeated Indians (57-44), 2-1 | Columbia Park (36-16) | 61-44 | |
| » Starters: Bill Bernhard vs Chief Bender | Second | 1½ out |
| Friday, August 17 |
| » Lost to Indians (58-44), 6-4 | Columbia Park (36-17) | 61-45 | |
| » Starters: Earl Moore vs Jack Coombs | Second | 2 out |
| » Defeated Indians (58-45), 4-2 | Columbia Park (37-17) | 62-45 | |
| » Starters: Otto Hess vs Andy Coakley | Second | 2 out |
| Saturday, August 18 |
| » Lost to Browns (56-51), 9-4 | Columbia Park (37-18) | 62-46 | |
| » Starters: Barney Pelty vs Jimmy Dygert | Second | 3 out |
| Monday, August 20 |
| » Lost to Browns (57-51), 7-1 | Columbia Park (37-19) | 62-47 | Lost 2 |
| » Starters: Fred Glade vs Rube Waddell | Second | 4 out |
| Tuesday, August 21 |
| » Tied Browns, 1-1 | Columbia Park (37-19) | 62-47 | |
| » Starters: Harry Howell vs Chief Bender | Second | 4 out |
| Wednesday, August 22 |
| » Defeated Browns (57-52), 5-3 | Columbia Park (38-19) | 63-47 | |
| » Starters: Barney Pelty vs Andy Coakley | Second | 4½ out |
| Thursday, August 23 |
| » Lost to Tigers (54-57), 7-6 | Columbia Park (38-20) | 63-48 | |
| » Starters: George Mullin vs Jimmy Dygert | Second | 5½ out |
| Saturday, August 25 |
| » Defeated Tigers (54-58), 4-3 | Columbia Park (39-20) | 64-48 | |
| » Starters: Bill Donovan vs Rube Waddell | Second | 4 out |
| Monday, August 27 |
| » Lost to White Sox (70-45), 1-0 | Columbia Park (39-21) | 64-49 | |
| » Starters: Ed Walsh vs Jack Coombs | Third | 5 out |
| Wednesday, August 29 |
| » Defeated White Sox (70-46), 4-3 | Columbia Park (40-21) | 65-49 | |
| » Starters: Ed Walsh vs Jimmy Dygert | Second | 4 out |
| Thursday, August 30 |
| » Lost to Red Sox (37-81), 3-2 | Huntington Ave Baseball Grounds (5-3) | 65-50 | |
| » Starters: Jack Coombs vs George Winter | Third | 4½ out |
| Friday, August 31 |
| » Lost to Red Sox (38-81), 8-1 | Huntington Ave Baseball Grounds (5-4) | 65-51 | Lost 2 |
| » Starters: Rube Waddell vs Ralph Glaze | Third | 5½ out |
| Saturday, September 1 |
| » Defeated Red Sox (38-82), 4-1 | Huntington Ave Baseball Grounds (6-4) | 66-51 | |
| » Starters: Jack Coombs vs Joe Harris | Third | 4½ out |
| Monday, September 3 |
| » Lost to Yankees (70-48), 4-3 | Hilltop Park (2-6) | 66-52 | |
| » Starters: Jimmy Dygert vs Slow Joe Doyle | Third | 4½ out |
| » Philadelphia forfeited to New York. | Hilltop Park (2-7) | 66-53 | Lost 2 |
| » Starters: Rube Waddell vs Jack Chesbro | Third | 4½ out |
| Tuesday, September 4 |
| » Defeated Senators (47-75), 10-3 | American League Park II (6-3) | 67-53 | |
| » Starters: Chief Bender vs Charlie Smith | Third | 4½ out |
| Wednesday, September 5 |
| » Defeated Senators (47-76), 3-1 | American League Park II (7-3) | 68-53 | Won 2 |
| » Starters: Jack Coombs vs Tom Hughes | Third | 4½ out |
| Thursday, September 6 |
| » Lost to Senators (48-76), 4-0 | American League Park II (7-4) | 68-54 | |
| » Starters: Jimmy Dygert vs Cy Falkenberg | Third | 5½ out |
| Friday, September 7 |
| » Lost to Yankees (75-48), 3-2 | Hilltop Park (2-8) | 68-55 | Lost 2 |
| » Starters: Rube Waddell vs Al Orth | Fourth | 6½ out |
| Saturday, September 8 |
| » Lost to Yankees (76-48), 11-4 | Hilltop Park (2-9) | 68-56 | Lost 3 |
| » Starters: Jim Holmes vs Jack Chesbro | Fourth | 7½ out |
| Monday, September 10 |
| » Defeated Senators (49-78), 2-1 | Columbia Park (41-21) | 69-56 | |
| » Starters: Cy Falkenberg vs Jack Coombs | Fourth | 6½ out |
| Tuesday, September 11 |
| » Defeated Senators (49-79), 4-1 | Columbia Park (42-21) | 70-56 | Won 2 |
| » Starters: Frank Kitson vs Rube Waddell | Third | 6½ out |
| Wednesday, September 12 |
| » Defeated Senators (49-80), 5-1 | Columbia Park (43-21) | 71-56 | Won 3 |
| » Starters: Casey Patten vs Mike Cunningham | Third | 5½ out |
| Thursday, September 13 |
| » Lost to Red Sox (43-89), 4-3 | Columbia Park (43-22) | 71-57 | |
| » Starters: Jesse Tannehill vs Eddie Plank | Third | 6½ out |
| » Major-league debuts: Jack Cameron (Red Sox) |
| Friday, September 14 |
| » Defeated Red Sox (43-90), 4-0 | Columbia Park (44-22) | 72-57 | |
| » Starters: Cy Young vs Rube Waddell | Third | 6 out |
| Saturday, September 15 |
| » Defeated Red Sox (43-91), 3-1 | Columbia Park (45-22) | 73-57 | Won 2 |
| » Starters: George Winter vs Jack Coombs | Third | 5½ out |
| » Defeated Red Sox (43-92), 2-0 | Columbia Park (46-22) | 74-57 | Won 3 |
| » Starters: Ed Barry vs Jimmy Dygert | Third | 5½ out |
| Monday, September 17 |
| » Lost to White Sox (82-51), 5-4 | South Side Park III (0-9) | 74-58 | |
| » Starters: Rube Waddell vs Ed Walsh | Third | 7 out |
| Tuesday, September 18 |
| » Lost to White Sox (83-51), 7-0 | South Side Park III (0-10) | 74-59 | Lost 2 |
| » Starters: Jack Coombs vs Frank Owen | Fourth | 8 out |
| Wednesday, September 19 |
| » Defeated White Sox (83-52), 4-3 | South Side Park III (1-10) | 75-59 | |
| » Starters: Jimmy Dygert vs Nick Altrock | Fourth | 7 out |
| Friday, September 21 |
| » Lost to Browns (68-68), 11-3 | Sportsman's Park II (4-5) | 75-60 | |
| » Starters: Rube Waddell vs Barney Pelty | Fourth | 7 out |
| Saturday, September 22 |
| » Lost to Browns (69-68), 7-5 | Sportsman's Park II (4-6) | 75-61 | Lost 2 |
| » Starters: Jack Coombs vs Fred Glade | Fourth | 7½ out |
| Sunday, September 23 |
| » Lost to Browns (70-68), 5-0 | Sportsman's Park II (4-7) | 75-62 | Lost 3 |
| » Starters: Rube Waddell vs Jack Powell | Fourth | 8 out |
| » Tied Browns, 0-0 | Sportsman's Park II (4-7) | 75-62 | |
| » Starters: Jimmy Dygert vs Harry Howell | Fourth | 8 out |
| Monday, September 24 |
| » Lost to Indians (81-59), 7-0 | League Park I (5-4) | 75-63 | Lost 4 |
| » Starters: Hack Schumann vs Bob Rhoads | Fourth | 8½ out |
| Tuesday, September 25 |
| » Lost to Indians (82-59), 5-0 | League Park I (5-5) | 75-64 | Lost 5 |
| » Starters: Jack Coombs vs Otto Hess | Fourth | 9½ out |
| Wednesday, September 26 |
| » Lost to Indians (83-59), 5-3 | League Park I (5-6) | 75-65 | Lost 6 |
| » Starters: Jimmy Dygert vs Addie Joss | Fourth | 10½ out |
| Thursday, September 27 |
| » Lost to Tigers (69-73), 3-0 | Bennett Park (4-4) | 75-66 | Lost 7 |
| » Starters: Rube Waddell vs George Mullin | Fourth | 11½ out |
| Friday, September 28 |
| » Defeated Tigers (69-74), 7-4 | Bennett Park (5-4) | 76-66 | |
| » Starters: Jack Coombs vs Red Donahue | Fourth | 11 out |
| Sunday, September 30 |
| » Major-league debuts: Lee Quillen (White Sox) |
| Tuesday, October 2 |
| » Defeated Yankees (86-60), 4-3 | Columbia Park (47-22) | 77-66 | Won 2 |
| » Starters: Jack Chesbro vs Jack Coombs | Fourth | 11½ out |
| Wednesday, October 3 |
| » Lost to Yankees (87-60), 7-5 | Columbia Park (47-23) | 77-67 | |
| » Starters: Walter Clarkson vs Hack Schumann | Fourth | 11½ out |
| » Defeated Yankees (87-61), 3-0 | Columbia Park (48-23) | 78-67 | |
| » Starters: Bill Hogg vs Jimmy Dygert | Fourth | 11½ out |
Game information provided by Retrosheet (www.retrosheet.org) |
