| Sunday, March 2 |
| Future Senator Moe Berg is born in New York, NY. |
| Tuesday, March 18 |
| Future Senator Squire Potter is born in Flatwoods, KY. |
| Thursday, April 17 |
| » Major-league debuts: Homer Smoot (Cardinals) |
| Friday, April 18 |
| » Major-league debuts: Red Dooin (Phillies) |
| Saturday, April 19 |
| » Major-league debuts: Patsy Dougherty (Red Sox) |
| Monday, April 21 |
| » Major-league debuts: Jack O'Neill (Cardinals) |
| Wednesday, April 23 |
| » Defeated Red Sox (1-1), 7-3 | American League Park I (1-0) | 1-0 | |
| » Starters: Bill Dinneen vs Al Orth | First | -- |
| » Major-league debuts: Lew Drill (Senators) |
| Thursday, April 24 |
| » Lost to Red Sox (2-1), 11-3 | American League Park I (1-1) | 1-1 | |
| » Starters: Cy Young vs Bill Carrick | Third | 1 out |
| Friday, April 25 |
| » Defeated Red Sox (2-2), 15-4 | American League Park I (2-1) | 2-1 | |
| » Starters: Bert Husting vs Happy Townsend | First | -- |
| Saturday, April 26 |
| » Defeated Red Sox (2-3), 15-7 | American League Park I (3-1) | 3-1 | Won 2 |
| » Starters: Bill Dinneen vs Watty Lee | First | -- |
| Monday, April 28 |
| » Lost to Athletics (2-2), 12-9 | American League Park I (3-2) | 3-2 | |
| » Starters: Snake Wiltse vs Al Orth | Second | 1 out |
| Tuesday, April 29 |
| » Defeated Athletics (2-3), 7-2 | American League Park I (4-2) | 4-2 | |
| » Starters: Eddie Plank vs Casey Patten | Second | 1 out |
| Wednesday, April 30 |
| » Lost to Athletics (3-3), 11-7 | American League Park I (4-3) | 4-3 | |
| » Starters: Snake Wiltse vs Happy Townsend | Third | ½ out |
| Thursday, May 1 |
| » Lost to Athletics (4-3), 6-3 | American League Park I (4-4) | 4-4 | Lost 2 |
| » Starters: Bill Duggleby vs Al Orth | Third | 1 out |
| Friday, May 2 |
| » Defeated Athletics (4-4), 7-6 | Columbia Park (1-0) | 5-4 | |
| » Starters: Casey Patten vs Eddie Plank | Second | 1 out |
| Saturday, May 3 |
| » Lost to Athletics (5-4), 9-3 | Columbia Park (1-1) | 5-5 | |
| » Starters: Bill Carrick vs Bert Husting | Fourth | 2 out |
| Monday, May 5 |
| » Lost to Athletics (6-4), 7-5 | Columbia Park (1-2) | 5-6 | Lost 2 |
| » Starters: Watty Lee vs Snake Wiltse | Fourth | 2 out |
| Tuesday, May 6 |
| » Lost to Athletics (7-4), 11-0 | Columbia Park (1-3) | 5-7 | Lost 3 |
| » Starters: Bill Carrick vs Eddie Plank | Sixth | 2½ out |
| Wednesday, May 7 |
| » Lost to Red Sox (8-5), 12-8 | Huntington Ave Baseball Grounds (0-1) | 5-8 | Lost 4 |
| » Starters: Happy Townsend vs Cy Young | Sixth | 3½ out |
| Thursday, May 8 |
| » Defeated Red Sox (8-6), 5-1 | Huntington Ave Baseball Grounds (1-1) | 6-8 | |
| » Starters: Casey Patten vs George Winter | Sixth | 3½ out |
| Friday, May 9 |
| » Defeated Red Sox (8-7), 5-4 | Huntington Ave Baseball Grounds (2-1) | 7-8 | Won 2 |
| » Starters: Watty Lee vs Bill Dinneen | Sixth | 3 out |
| Saturday, May 10 |
| » Lost to Red Sox (9-7), 3-1 | Huntington Ave Baseball Grounds (2-2) | 7-9 | |
| » Starters: Al Orth vs Cy Young | Sixth | 3½ out |
| Monday, May 12 |
| » Lost to Orioles (6-10), 9-4 | Oriole Park IV (0-1) | 7-10 | Lost 2 |
| » Starters: Casey Patten vs Joe McGinnity | Sixth | 4½ out |
| Tuesday, May 13 |
| » Lost to Orioles (7-10), 10-3 | Oriole Park IV (0-2) | 7-11 | Lost 3 |
| » Starters: Bill Carrick vs Tom Hughes | Seventh | 4½ out |
| Wednesday, May 14 |
| » Defeated Orioles (7-11), 4-1 | American League Park I (5-4) | 8-11 | |
| » Starters: Harry Howell vs Happy Townsend | Fifth | 4 out |
| Thursday, May 15 |
| » Lost to Orioles (8-11), 6-2 | American League Park I (5-5) | 8-12 | |
| » Starters: Joe McGinnity vs Watty Lee | Sixth | 4 out |
| Friday, May 16 |
| » Defeated Orioles (8-12), 9-7 | Oriole Park IV (1-2) | 9-12 | |
| » Starters: Al Orth vs Charlie Shields | Sixth | 4 out |
| Saturday, May 17 |
| » Lost to Orioles (9-12), 7-5 | Oriole Park IV (1-3) | 9-13 | |
| » Starters: Casey Patten vs Tom Hughes | Seventh | 4 out |
| Tuesday, May 20 |
| » Lost to Orioles (10-12), 4-3 | American League Park I (5-6) | 9-14 | Lost 2 |
| » Starters: Joe McGinnity vs Happy Townsend | Sixth | 4½ out |
| Wednesday, May 21 |
| » Defeated Browns (11-9), 5-4 | American League Park I (6-6) | 10-14 | |
| » Starters: Jack Powell vs Al Orth | Sixth | 4½ out |
| Thursday, May 22 |
| » Lost to Browns (12-9), 9-1 | American League Park I (6-7) | 10-15 | |
| » Starters: Bill Reidy vs Watty Lee | Seventh | 5½ out |
| Future Senator Al Simmons is born in Milwaukee, WI. |
| Friday, May 23 |
| » Lost to Browns (13-9), 7-5 | American League Park I (6-8) | 10-16 | Lost 2 |
| » Starters: Jack Harper vs Casey Patten | Sixth | 5½ out |
| Saturday, May 24 |
| » Defeated Browns (13-10), 5-1 | American League Park I (7-8) | 11-16 | |
| » Starters: Red Donahue vs Happy Townsend | Sixth | 4½ out |
| Monday, May 26 |
| » Lost to Indians (9-19), 6-3 | American League Park I (7-9) | 11-17 | |
| » Starters: Gene Wright vs Al Orth | Seventh | 5½ out |
| Tuesday, May 27 |
| » Defeated Indians (9-20), 7-1 | American League Park I (8-9) | 12-17 | |
| » Starters: Earl Moore vs Casey Patten | Fifth | 4½ out |
| Wednesday, May 28 |
| » Lost to Indians (10-20), 7-2 | American League Park I (8-10) | 12-18 | |
| » Starters: Addie Joss vs Happy Townsend | Fifth | 5½ out |
| Thursday, May 29 |
| » Defeated Indians (10-21), 16-4 | American League Park I (9-10) | 13-18 | |
| » Starters: Oscar Streit vs Al Orth | Sixth | 5½ out |
| Friday, May 30 |
| » Defeated White Sox (16-13), 9-3 | American League Park I (10-10) | 14-18 | Won 2 |
| » Starters: Ned Garvin vs Bill Carrick | Sixth | 5½ out |
| » Lost to White Sox (17-13), 3-2 | American League Park I (10-11) | 14-19 | |
| » Starters: Nixey Callahan vs Casey Patten | Sixth | 5½ out |
| Saturday, May 31 |
| » Lost to White Sox (18-13), 4-1 | American League Park I (10-12) | 14-20 | Lost 2 |
| » Starters: Roy Patterson vs Happy Townsend | Seventh | 6½ out |
| Monday, June 2 |
| » Defeated White Sox (18-14), 12-0 | American League Park I (11-12) | 15-20 | |
| » Starters: Clark Griffith vs Al Orth | Seventh | 6½ out |
| Tuesday, June 3 |
| » Defeated Tigers (16-16), 2-0 | American League Park I (12-12) | 16-20 | Won 2 |
| » Starters: Win Mercer vs Casey Patten | Seventh | 6½ out |
| Wednesday, June 4 |
| » Defeated Tigers (16-17), 13-6 | American League Park I (13-12) | 17-20 | Won 3 |
| » Starters: Roscoe Miller vs Bill Carrick | Sixth | 5½ out |
| Thursday, June 5 |
| » Defeated Tigers (16-18), 5-3 | American League Park I (14-12) | 18-20 | Won 4 |
| » Starters: George Mullin vs Casey Patten | Sixth | 4½ out |
| Sunday, June 8 |
| » Lost to White Sox (21-15), 14-7 | South Side Park III (0-1) | 18-21 | |
| » Starters: Happy Townsend vs Wiley Piatt | Seventh | 5 out |
| Monday, June 9 |
| » Lost to White Sox (22-15), 2-1 | South Side Park III (0-2) | 18-22 | Lost 2 |
| » Starters: Al Orth vs Roy Patterson | Seventh | 5½ out |
| Tuesday, June 10 |
| » Lost to White Sox (23-15), 4-3 | South Side Park III (0-3) | 18-23 | Lost 3 |
| » Starters: Casey Patten vs Ned Garvin | Sixth | 6½ out |
| Wednesday, June 11 |
| » Lost to Browns (20-19), 6-3 | Sportsman's Park II (0-1) | 18-24 | Lost 4 |
| » Starters: Happy Townsend vs Jack Powell | Sixth | 7½ out |
| Thursday, June 12 |
| » Defeated Browns (20-20), 9-8 | Sportsman's Park II (1-1) | 19-24 | |
| » Starters: Bill Carrick vs Willie Sudhoff | Sixth | 7½ out |
| Former Senator Tim Donahue dies in Taunton, MA at the age of 33. |
| Friday, June 13 |
| » Defeated Browns (20-21), 11-1 | Sportsman's Park II (2-1) | 20-24 | Won 2 |
| » Starters: Al Orth vs Red Donahue | Sixth | 7½ out |
| Saturday, June 14 |
| » Defeated Browns (20-22), 5-4 | Sportsman's Park II (3-1) | 21-24 | Won 3 |
| » Starters: Happy Townsend vs Jack Powell | Sixth | 6½ out |
| Sunday, June 15 |
| » Lost to Tigers (21-22), 11-2 | Burns Park (0-1) | 21-25 | |
| » Starters: Casey Patten vs George Mullin | Sixth | 7 out |
| Monday, June 16 |
| » Defeated Tigers (21-23), 6-4 | Bennett Park (1-0) | 22-25 | |
| » Starters: Al Orth vs Joe Yeager | Sixth | 7 out |
| Tuesday, June 17 |
| » Lost to Tigers (22-23), 4-0 | Bennett Park (1-1) | 22-26 | |
| » Starters: Watty Lee vs Win Mercer | Seventh | 8 out |
| Wednesday, June 18 |
| » Lost to Tigers (23-23), 4-1 | Bennett Park (1-2) | 22-27 | Lost 2 |
| » Starters: Casey Patten vs George Mullin | Seventh | 8½ out |
| Thursday, June 19 |
| » Defeated Indians (20-31), 5-3 | League Park I (1-0) | 23-27 | |
| » Starters: Al Orth vs Bill Bernhard | Sixth | 8½ out |
| Friday, June 20 |
| » Lost to Indians (21-31), 8-5 | League Park I (1-1) | 23-28 | |
| » Starters: Happy Townsend vs Gene Wright | Sixth | 9 out |
| Saturday, June 21 |
| » Defeated Indians (21-32), 14-9 | League Park I (2-1) | 24-28 | |
| » Starters: Casey Patten vs Earl Moore | Sixth | 9 out |
| Sunday, June 22 |
| » Lost to Indians (22-32), 6-4 | Jailhouse Flats (0-1) | 24-29 | |
| » Starters: Bill Carrick vs Addie Joss | Sixth | 8½ out |
| Tuesday, June 24 |
| » Defeated Red Sox (29-25), 7-6 | American League Park I (15-12) | 25-29 | |
| » Starters: Cy Young vs Al Orth | Fifth | 9 out |
| » Major-league debuts: Doc Adkins (Red Sox) |
| Wednesday, June 25 |
| » Defeated Red Sox (29-26), 4-3 | American League Park I (16-12) | 26-29 | Won 2 |
| » Starters: Bill Dinneen vs Casey Patten | Fifth | 8½ out |
| Thursday, June 26 |
| » Lost to Red Sox (30-26), 4-2 | American League Park I (16-13) | 26-30 | |
| » Starters: Doc Adkins vs Bill Carrick | Seventh | 8½ out |
| Friday, June 27 |
| » Lost to Athletics (27-25), 4-2 | American League Park I (16-14) | 26-31 | Lost 2 |
| » Starters: Snake Wiltse vs Happy Townsend | Seventh | 9 out |
| Saturday, June 28 |
| » Defeated Athletics (27-26), 4-3 | American League Park I (17-14) | 27-31 | |
| » Starters: Eddie Plank vs Al Orth | Sixth | 8½ out |
| Tuesday, July 1 |
| » Lost to Red Sox (33-26), 9-2 | Huntington Ave Baseball Grounds (2-3) | 27-32 | |
| » Starters: Casey Patten vs Bill Dinneen | Fifth | 9½ out |
| Wednesday, July 2 |
| » Defeated Red Sox (33-27), 8-3 | Huntington Ave Baseball Grounds (3-3) | 28-32 | |
| » Starters: Al Orth vs Doc Adkins | Fifth | 8 out |
| » Major-league debuts: Dave Williams (Red Sox) |
| Friday, July 4 |
| » Lost to Athletics (29-27), 3-1 | Columbia Park (1-4) | 28-33 | |
| » Starters: Bill Carrick vs Fred Mitchell | Fifth | 10½ out |
| » Lost to Athletics (30-27), 12-9 | Columbia Park (1-5) | 28-34 | Lost 2 |
| » Starters: Casey Patten vs Rube Waddell | Fifth | 10½ out |
| Saturday, July 5 |
| » Defeated Athletics (30-28), 9-5 | Columbia Park (2-5) | 29-34 | |
| » Starters: Bill Carrick vs Snake Wiltse | Fifth | 10½ out |
| Monday, July 7 |
| » Lost to Orioles (29-34), 13-0 | Oriole Park IV (1-4) | 29-35 | |
| » Starters: Al Orth vs Harry Howell | Seventh | 10 out |
| Tuesday, July 8 |
| » Lost to Orioles (30-34), 8-1 | Oriole Park IV (1-5) | 29-36 | Lost 2 |
| » Starters: Al Orth vs Jack Cronin | Sixth | 11 out |
| Wednesday, July 9 |
| » Lost to Orioles (31-34), 11-4 | Oriole Park IV (1-6) | 29-37 | Lost 3 |
| » Starters: Casey Patten vs Joe McGinnity | Sixth | 11½ out |
| Thursday, July 10 |
| » Defeated Orioles (31-35), 7-3 | American League Park I (18-14) | 30-37 | |
| » Starters: Harry Howell vs Bill Carrick | Sixth | 11 out |
| Friday, July 11 |
| » Defeated Orioles (31-36), 4-3 | American League Park I (19-14) | 31-37 | Won 2 |
| » Starters: Jack Cronin vs Happy Townsend | Sixth | 11 out |
| Saturday, July 12 |
| » Defeated Orioles (31-37), 4-1 | American League Park I (20-14) | 32-37 | Won 3 |
| » Starters: Joe McGinnity vs Al Orth | Fifth | 11 out |
| Monday, July 14 |
| » Defeated Orioles (31-38), 10-9 | American League Park I (21-14) | 33-37 | Won 4 |
| » Starters: Charlie Shields vs Bill Carrick | Fifth | 10½ out |
| Tuesday, July 15 |
| » Defeated Tigers (28-40), 5-4 | American League Park I (22-14) | 34-37 | Won 5 |
| » Starters: George Mullin vs Happy Townsend | Fifth | 9½ out |
| Wednesday, July 16 |
| » Lost to Tigers (29-40), 13-8 | American League Park I (22-15) | 34-38 | |
| » Starters: Joe Yeager vs Al Orth | Fifth | 10½ out |
| Thursday, July 17 |
| » Defeated Tigers (29-41), 9-2 | American League Park I (23-15) | 35-38 | |
| » Starters: Roscoe Miller vs Casey Patten | Fifth | 9½ out |
| Saturday, July 19 |
| » Lost to Browns (39-31), 6-4 | American League Park I (23-16) | 35-39 | |
| » Starters: Red Donahue vs Bill Carrick | Fifth | 9 out |
| Monday, July 21 |
| » Defeated Browns (39-32), 2-1 | American League Park I (24-16) | 36-39 | |
| » Starters: Jack Powell vs Al Orth | Fourth | 8 out |
| Tuesday, July 22 |
| » Lost to Browns (40-32), 7-6 | American League Park I (24-17) | 36-40 | |
| » Starters: Jack Harper vs Happy Townsend | Fourth | 8 out |
| Wednesday, July 23 |
| » Defeated Indians (35-43), 6-5 | American League Park I (25-17) | 37-40 | |
| » Starters: Earl Moore vs Casey Patten | Fifth | 7 out |
| Thursday, July 24 |
| » Defeated Indians (35-44), 3-1 | American League Park I (26-17) | 38-40 | Won 2 |
| » Starters: Bill Bernhard vs Bill Carrick | Fifth | 6½ out |
| Friday, July 25 |
| » Lost to Indians (36-44), 6-3 | American League Park I (26-18) | 38-41 | |
| » Starters: Addie Joss vs Al Orth | Fifth | 7 out |
| Saturday, July 26 |
| » Lost to White Sox (44-32), 10-9 | American League Park I (26-19) | 38-42 | Lost 2 |
| » Starters: Wiley Piatt vs Casey Patten | Fifth | 8 out |
| Monday, July 28 |
| » Defeated White Sox (44-33), 12-2 | American League Park I (27-19) | 39-42 | |
| » Starters: Nixey Callahan vs Watty Lee | Fifth | 7 out |
| Tuesday, July 29 |
| » Defeated White Sox (44-34), 5-2 | American League Park I (28-19) | 40-42 | Won 2 |
| » Starters: Roy Patterson vs Bill Carrick | Fifth | 6 out |
| Thursday, July 31 |
| » Lost to Tigers (33-45), 9-1 | Bennett Park (1-3) | 40-43 | |
| » Starters: Al Orth vs George Mullin | Fifth | 6 out |
| Friday, August 1 |
| » Lost to Tigers (34-45), 13-0 | Bennett Park (1-4) | 40-44 | Lost 2 |
| » Starters: Happy Townsend vs Ed Siever | Fifth | 7 out |
| Saturday, August 2 |
| » Lost to Tigers (35-45), 8-0 | Bennett Park (1-5) | 40-45 | Lost 3 |
| » Starters: Casey Patten vs Win Mercer | Fifth | 8½ out |
| Sunday, August 3 |
| » Defeated Indians (39-49), 5-2 | Neil Park I (1-0) | 41-45 | |
| » Starters: Bill Carrick vs Bill Bernhard | Fifth | 8½ out |
| » Major-league debuts: Otto Hess (Indians) |
| Monday, August 4 |
| » Lost to Indians (40-49), 1-0 | League Park I (2-2) | 41-46 | |
| » Starters: Al Orth vs Earl Moore | Fifth | 9½ out |
| Tuesday, August 5 |
| » Lost to Indians (41-49), 7-6 | League Park I (2-3) | 41-47 | Lost 2 |
| » Starters: Casey Patten vs Otto Hess | Fifth | 9½ out |
| Wednesday, August 6 |
| » Lost to White Sox (50-36), 5-2 | South Side Park III (0-4) | 41-48 | Lost 3 |
| » Starters: Bill Carrick vs Roy Patterson | Sixth | 10½ out |
| Thursday, August 7 |
| » Defeated White Sox (50-37), 4-1 | South Side Park III (1-4) | 42-48 | |
| » Starters: Al Orth vs Ned Garvin | Fifth | 9½ out |
| Friday, August 8 |
| » Defeated White Sox (50-38), 5-2 | South Side Park III (2-4) | 43-48 | Won 2 |
| » Starters: Casey Patten vs Nixey Callahan | Fifth | 8½ out |
| Saturday, August 9 |
| » Lost to Browns (48-39), 12-4 | Sportsman's Park II (3-2) | 43-49 | |
| » Starters: Happy Townsend vs Jack Powell | Sixth | 9½ out |
| Sunday, August 10 |
| » Lost to Browns (49-39), 6-3 | Sportsman's Park II (3-3) | 43-50 | Lost 2 |
| » Starters: Al Orth vs Red Donahue | Sixth | 9½ out |
| Monday, August 11 |
| » Lost to Browns (50-39), 8-1 | Sportsman's Park II (3-4) | 43-51 | Lost 3 |
| » Starters: Casey Patten vs Jack Harper | Sixth | 10½ out |
| Wednesday, August 13 |
| » Lost to Browns (51-39), 7-5 | American League Park I (28-20) | 43-52 | Lost 4 |
| » Starters: Jack Powell vs Bill Carrick | Sixth | 10½ out |
| Friday, August 15 |
| » Defeated Browns (51-40), 6-2 | American League Park I (29-20) | 44-52 | |
| » Starters: Red Donahue vs Al Orth | Sixth | 9½ out |
| » Defeated Browns (51-41), 2-1 | American League Park I (30-20) | 45-52 | Won 2 |
| » Starters: Jack Harper vs Casey Patten | Sixth | 9½ out |
| Saturday, August 16 |
| » Lost to Indians (48-51), 4-3 | American League Park I (30-21) | 45-53 | |
| » Starters: Earl Moore vs Bill Carrick | Sixth | 10½ out |
| Monday, August 18 |
| » Lost to Indians (49-51), 6-3 | American League Park I (30-22) | 45-54 | Lost 2 |
| » Starters: Bill Bernhard vs Al Orth | Sixth | 11½ out |
| Tuesday, August 19 |
| » Defeated Indians (49-52), 5-4 | American League Park I (31-22) | 46-54 | |
| » Starters: Dummy Leitner vs Casey Patten | Sixth | 10½ out |
| Wednesday, August 20 |
| » Lost to White Sox (54-44), 10-6 | American League Park I (31-23) | 46-55 | |
| » Starters: Nixey Callahan vs Bill Carrick | Sixth | 11½ out |
| Thursday, August 21 |
| » Defeated White Sox (54-45), 6-4 | American League Park I (32-23) | 47-55 | |
| » Starters: Nixey Callahan vs Al Orth | Sixth | 11½ out |
| Friday, August 22 |
| » Lost to White Sox (55-45), 9-6 | American League Park I (32-24) | 47-56 | |
| » Starters: Clark Griffith vs Happy Townsend | Sixth | 12½ out |
| Saturday, August 23 |
| » Defeated Tigers (40-59), 6-2 | American League Park I (33-24) | 48-56 | |
| » Starters: Arch McCarthy vs Casey Patten | Sixth | 12½ out |
| Monday, August 25 |
| » Defeated Tigers (40-60), 8-6 | American League Park I (34-24) | 49-56 | Won 2 |
| » Starters: Joe Yeager vs Bill Carrick | Sixth | 12 out |
| » Defeated Tigers (40-61), 10-7 | American League Park I (35-24) | 50-56 | Won 3 |
| » Starters: George Mullin vs Al Orth | Sixth | 12 out |
| Tuesday, August 26 |
| » Defeated Tigers (40-62), 8-7 | American League Park I (36-24) | 51-56 | Won 4 |
| » Starters: Arch McCarthy vs Casey Patten | Fifth | 12 out |
| Thursday, August 28 |
| » Lost to Indians (53-56), 5-3 | League Park I (2-4) | 51-57 | |
| » Starters: Bill Carrick vs Addie Joss | Sixth | 12 out |
| Friday, August 29 |
| » Lost to Indians (54-56), 4-2 | League Park I (2-5) | 51-58 | Lost 2 |
| » Starters: Happy Townsend vs Earl Moore | Sixth | 13 out |
| Saturday, August 30 |
| » Lost to Indians (55-56), 4-0 | League Park I (2-6) | 51-59 | Lost 3 |
| » Starters: Al Orth vs Bill Bernhard | Sixth | 13½ out |
| Sunday, August 31 |
| » Defeated Tigers (41-65), 10-7 | Burns Park (1-1) | 52-59 | |
| » Starters: Bill Carrick vs Ed Siever | Sixth | 12 out |
| Monday, September 1 |
| » Lost to Tigers (42-65), 4-2 | Bennett Park (1-6) | 52-60 | |
| » Starters: Casey Patten vs Arch McCarthy | Sixth | 12 out |
| » Lost to Tigers (43-65), 13-1 | Bennett Park (1-7) | 52-61 | Lost 2 |
| » Starters: Watty Lee vs George Mullin | Sixth | 12 out |
| Wednesday, September 3 |
| » Lost to Browns (62-48), 9-4 | Sportsman's Park II (3-5) | 52-62 | Lost 3 |
| » Starters: Al Orth vs Red Donahue | Sixth | 13 out |
| » Defeated Browns (62-49), 4-2 | Sportsman's Park II (4-5) | 53-62 | |
| » Starters: Happy Townsend vs Willie Sudhoff | Sixth | 13 out |
| Thursday, September 4 |
| » Lost to Browns (63-49), 9-3 | Sportsman's Park II (4-6) | 53-63 | |
| » Starters: Bill Carrick vs Jack Powell | Sixth | 14 out |
| Friday, September 5 |
| » Lost to White Sox (62-52), 11-3 | South Side Park III (2-5) | 53-64 | Lost 2 |
| » Starters: Casey Patten vs Nixey Callahan | Sixth | 14 out |
| Saturday, September 6 |
| » Lost to White Sox (63-52), 7-4 | South Side Park III (2-6) | 53-65 | Lost 3 |
| » Starters: Al Orth vs Wiley Piatt | Sixth | 15 out |
| Sunday, September 7 |
| » Lost to White Sox (64-52), 6-3 | South Side Park III (2-7) | 53-66 | Lost 4 |
| » Starters: Happy Townsend vs Roy Patterson | Sixth | 15½ out |
| » Tied White Sox, 3-3 | South Side Park III (2-7) | 53-66 | |
| » Starters: Bill Carrick vs Clark Griffith | Sixth | 15½ out |
| Tuesday, September 9 |
| » Defeated Red Sox (66-52), 3-2 | Huntington Ave Baseball Grounds (4-3) | 54-66 | |
| » Starters: Casey Patten vs Cy Young | Sixth | 15½ out |
| Wednesday, September 10 |
| » Lost to Red Sox (67-52), 5-3 | Huntington Ave Baseball Grounds (4-4) | 54-67 | |
| » Starters: Al Orth vs Bill Dinneen | Sixth | 17½ out |
| » Lost to Red Sox (68-52), 7-5 | Huntington Ave Baseball Grounds (4-5) | 54-68 | Lost 2 |
| » Starters: Happy Townsend vs Tully Sparks | Sixth | 17½ out |
| Thursday, September 11 |
| » Defeated Red Sox (68-53), 9-7 | Huntington Ave Baseball Grounds (5-5) | 55-68 | |
| » Starters: Bill Carrick vs Tom Hughes | Sixth | 18 out |
| Friday, September 12 |
| » Defeated Orioles (46-76), 15-1 | Oriole Park IV (2-6) | 56-68 | Won 2 |
| » Starters: Watty Lee vs Jack Katoll | Sixth | 17 out |
| Sunday, September 14 |
| » Major-league debuts: Peaches Graham (Indians) |
| Monday, September 15 |
| » Defeated Orioles (46-77), 11-8 | Oriole Park IV (3-6) | 57-68 | Won 3 |
| » Starters: Al Orth vs Snake Wiltse | Sixth | 17½ out |
| » Tied Orioles, 4-4 | Oriole Park IV (3-6) | 57-68 | |
| » Starters: Happy Townsend vs Ike Butler | Sixth | 17½ out |
| Tuesday, September 16 |
| » Lost to Athletics (75-50), 7-5 | Columbia Park (2-6) | 57-69 | |
| » Starters: Casey Patten vs Bert Husting | Sixth | 18½ out |
| Wednesday, September 17 |
| » Lost to Athletics (76-50), 6-5 | Columbia Park (2-7) | 57-70 | Lost 2 |
| » Starters: Bill Carrick vs Andy Coakley | Sixth | 19½ out |
| Thursday, September 18 |
| » Lost to Athletics (77-50), 6-2 | Columbia Park (2-8) | 57-71 | Lost 3 |
| » Starters: Cy Vorhees vs Bert Husting | Sixth | 20½ out |
| Saturday, September 20 |
| » Lost to Orioles (48-80), 6-5 | American League Park I (36-25) | 57-72 | Lost 4 |
| » Starters: Jack Katoll vs Al Orth | Sixth | 22½ out |
| » Lost to Orioles (49-80), 9-6 | American League Park I (36-26) | 57-73 | Lost 5 |
| » Starters: Ike Butler vs Bill Carrick | Sixth | 22½ out |
| Monday, September 22 |
| » Lost to Orioles (50-80), 9-4 | American League Park I (36-27) | 57-74 | Lost 6 |
| » Starters: Snake Wiltse vs Watty Lee | Sixth | 22½ out |
| » Defeated Orioles (50-81), 14-3 | American League Park I (37-27) | 58-74 | |
| » Starters: Ernie Ross vs Happy Townsend | Sixth | 22½ out |
| Tuesday, September 23 |
| » Lost to Red Sox (74-59), 14-1 | American League Park I (37-28) | 58-75 | |
| » Starters: Bill Dinneen vs Bill Carrick | Sixth | 23½ out |
| Wednesday, September 24 |
| » Defeated Red Sox (74-60), 8-2 | American League Park I (38-28) | 59-75 | |
| » Starters: Tully Sparks vs Al Orth | Sixth | 24 out |
| Saturday, September 27 |
| » Defeated Athletics (83-52), 9-4 | American League Park I (39-28) | 60-75 | Won 2 |
| » Starters: Tad Quinn vs Happy Townsend | Sixth | 22 out |
| » Defeated Athletics (83-53), 7-5 | American League Park I (40-28) | 61-75 | Won 3 |
| » Starters: Tom Walker vs Casey Patten | Sixth | 22 out |
| » Major-league debuts: Tad Quinn (Athletics) |
| Sunday, October 5 |
| » Major-league debuts: Otto Williams (Cardinals) |
Game information provided by Retrosheet (www.retrosheet.org) |
