| Saturday, April 5 |
| Former Oriole Dave Eggler dies in Buffalo, NY at the age of 51. |
| Thursday, April 17 |
| » Major-league debuts: Homer Smoot (Cardinals) |
| Friday, April 18 |
| » Major-league debuts: Red Dooin (Phillies) |
| Saturday, April 19 |
| » Lost to Red Sox (1-0), 7-6 | Huntington Ave Baseball Grounds (0-1) | 0-1 | |
| » Starters: Tom Hughes vs Cy Young | Third | 1 out |
| » Major-league debuts: Patsy Dougherty (Red Sox) |
| Monday, April 21 |
| » Major-league debuts: Jack O'Neill (Cardinals) |
| Wednesday, April 23 |
| » Lost to Athletics (1-0), 8-1 | Oriole Park IV (0-1) | 0-2 | Lost 2 |
| » Starters: Bill Bernhard vs Joe McGinnity | Fourth | 1½ out |
| » Major-league debuts: Luis Castro (Athletics) |
| Thursday, April 24 |
| » Defeated Athletics (1-1), 6-2 | Oriole Park IV (1-1) | 1-2 | |
| » Starters: Eddie Plank vs Tom Hughes | Fourth | 1½ out |
| Saturday, April 26 |
| » Defeated Athletics (1-2), 6-2 | Oriole Park IV (2-1) | 2-2 | Won 2 |
| » Starters: Bill Duggleby vs Harry Howell | Third | 1 out |
| Monday, April 28 |
| » Lost to Red Sox (3-3), 7-3 | Oriole Park IV (2-2) | 2-3 | |
| » Starters: Cy Young vs Joe McGinnity | Fifth | 1 out |
| Wednesday, April 30 |
| » Defeated Red Sox (3-4), 5-4 | Oriole Park IV (3-2) | 3-3 | |
| » Starters: George Winter vs Tom Hughes | Fourth | 1 out |
| Thursday, May 1 |
| » Lost to Red Sox (4-4), 6-4 | Oriole Park IV (3-3) | 3-4 | |
| » Starters: Bill Dinneen vs Harry Howell | Fourth | 1½ out |
| Friday, May 2 |
| » Defeated Red Sox (4-5), 14-6 | Huntington Ave Baseball Grounds (1-1) | 4-4 | |
| » Starters: Joe McGinnity vs Cy Young | Third | 1½ out |
| Saturday, May 3 |
| » Lost to Red Sox (5-5), 10-1 | Huntington Ave Baseball Grounds (1-2) | 4-5 | |
| » Starters: Charlie Shields vs Cy Young | Fifth | 2½ out |
| Monday, May 5 |
| » Lost to Red Sox (6-5), 5-2 | Huntington Ave Baseball Grounds (1-3) | 4-6 | Lost 2 |
| » Starters: Tom Hughes vs George Winter | Sixth | 2½ out |
| Tuesday, May 6 |
| » Lost to Red Sox (7-5), 5-4 | Huntington Ave Baseball Grounds (1-4) | 4-7 | Lost 3 |
| » Starters: Frank Foreman vs Bill Dinneen | Seventh | 3 out |
| Wednesday, May 7 |
| » Lost to Athletics (8-4), 6-5 | Columbia Park (0-1) | 4-8 | Lost 4 |
| » Starters: Joe McGinnity vs Bert Husting | Seventh | 4 out |
| Thursday, May 8 |
| » Lost to Athletics (9-4), 6-3 | Columbia Park (0-2) | 4-9 | Lost 5 |
| » Starters: Harry Howell vs Snake Wiltse | Seventh | 5 out |
| Friday, May 9 |
| » Defeated Athletics (9-5), 13-6 | Columbia Park (1-2) | 5-9 | |
| » Starters: Tom Hughes vs Ed Kenna | Seventh | 4½ out |
| Saturday, May 10 |
| » Lost to Athletics (10-5), 13-4 | Columbia Park (1-3) | 5-10 | |
| » Starters: Frank Foreman vs Bert Husting | Seventh | 5 out |
| Monday, May 12 |
| » Defeated Senators (7-10), 9-4 | Oriole Park IV (4-3) | 6-10 | |
| » Starters: Casey Patten vs Joe McGinnity | Seventh | 5 out |
| Tuesday, May 13 |
| » Defeated Senators (7-11), 10-3 | Oriole Park IV (5-3) | 7-10 | Won 2 |
| » Starters: Bill Carrick vs Tom Hughes | Sixth | 4 out |
| Wednesday, May 14 |
| » Lost to Senators (8-11), 4-1 | American League Park I (0-1) | 7-11 | |
| » Starters: Harry Howell vs Happy Townsend | Sixth | 4½ out |
| Thursday, May 15 |
| » Defeated Senators (8-12), 6-2 | American League Park I (1-1) | 8-11 | |
| » Starters: Joe McGinnity vs Watty Lee | Fifth | 3½ out |
| Friday, May 16 |
| » Lost to Senators (9-12), 9-7 | Oriole Park IV (5-4) | 8-12 | |
| » Starters: Al Orth vs Charlie Shields | Seventh | 4½ out |
| Saturday, May 17 |
| » Defeated Senators (9-13), 7-5 | Oriole Park IV (6-4) | 9-12 | |
| » Starters: Casey Patten vs Tom Hughes | Sixth | 3½ out |
| Tuesday, May 20 |
| » Defeated Senators (9-14), 4-3 | American League Park I (2-1) | 10-12 | Won 2 |
| » Starters: Joe McGinnity vs Happy Townsend | Fifth | 3 out |
| Wednesday, May 21 |
| » Lost to Tigers (13-8), 4-2 | Oriole Park IV (6-5) | 10-13 | |
| » Starters: Win Mercer vs Tom Hughes | Fifth | 4 out |
| Thursday, May 22 |
| » Defeated Tigers (13-9), 3-1 | Oriole Park IV (7-5) | 11-13 | |
| » Starters: Roscoe Miller vs Harry Howell | Sixth | 4 out |
| Friday, May 23 |
| » Lost to Tigers (14-9), 3-2 | Oriole Park IV (7-6) | 11-14 | |
| » Starters: Ed Siever vs Joe McGinnity | Fifth | 4 out |
| Saturday, May 24 |
| » Defeated Tigers (14-10), 6-0 | Oriole Park IV (8-6) | 12-14 | |
| » Starters: Win Mercer vs Tom Hughes | Fifth | 3 out |
| Monday, May 26 |
| » Lost to White Sox (15-10), 8-3 | Oriole Park IV (8-7) | 12-15 | |
| » Starters: Ned Garvin vs Harry Howell | Sixth | 4 out |
| Tuesday, May 27 |
| » Defeated White Sox (15-11), 7-1 | Oriole Park IV (9-7) | 13-15 | |
| » Starters: Roy Patterson vs Joe McGinnity | Fourth | 3 out |
| Wednesday, May 28 |
| » Lost to White Sox (16-11), 5-2 | Oriole Park IV (9-8) | 13-16 | |
| » Starters: Clark Griffith vs Tom Hughes | Fourth | 4 out |
| Thursday, May 29 |
| » Defeated White Sox (16-12), 6-5 | Oriole Park IV (10-8) | 14-16 | |
| » Starters: Wiley Piatt vs Joe McGinnity | Fifth | 4 out |
| Friday, May 30 |
| » Defeated Indians (10-22), 12-4 | Oriole Park IV (11-8) | 15-16 | Won 2 |
| » Starters: Gene Wright vs Harry Howell | Fifth | 3 out |
| » Defeated Indians (10-23), 10-7 | Oriole Park IV (12-8) | 16-16 | Won 3 |
| » Starters: Earl Moore vs Tom Hughes | Fifth | 3 out |
| Saturday, May 31 |
| » Lost to Indians (11-23), 6-3 | Oriole Park IV (12-9) | 16-17 | |
| » Starters: Addie Joss vs Bob Lawson | Sixth | 4 out |
| Monday, June 2 |
| » Defeated Indians (11-24), 14-1 | Oriole Park IV (13-9) | 17-17 | |
| » Starters: Oscar Streit vs Joe McGinnity | Fifth | 4 out |
| Tuesday, June 3 |
| » Defeated Browns (15-17), 7-6 | Oriole Park IV (14-9) | 18-17 | Won 2 |
| » Starters: Red Donahue vs Joe McGinnity | Fourth | 4 out |
| Wednesday, June 4 |
| » Lost to Browns (16-17), 6-2 | Oriole Park IV (14-10) | 18-18 | |
| » Starters: Jack Harper vs Harry Howell | Fourth | 4 out |
| Thursday, June 5 |
| » Lost to Browns (17-17), 7-6 | Oriole Park IV (14-11) | 18-19 | Lost 2 |
| » Starters: Bill Reidy vs Tom Hughes | Fifth | 4 out |
| Saturday, June 7 |
| » Lost to Indians (14-25), 7-3 | League Park I (0-1) | 18-20 | Lost 3 |
| » Starters: Joe McGinnity vs Bill Bernhard | Sixth | 4 out |
| Sunday, June 8 |
| » Defeated Indians (14-26), 6-2 | Fairview Park (1-0) | 19-20 | |
| » Starters: Tom Hughes vs Earl Moore | Fifth | 4 out |
| Monday, June 9 |
| » Lost to Indians (15-26), 10-5 | League Park I (0-2) | 19-21 | |
| » Starters: Bob Lawson vs Addie Joss | Sixth | 4½ out |
| Tuesday, June 10 |
| » Lost to Indians (16-26), 10-7 | League Park I (0-3) | 19-22 | Lost 2 |
| » Starters: Harry Howell vs Bill Bernhard | Fifth | 5½ out |
| Wednesday, June 11 |
| » Lost to Tigers (20-19), 5-2 | Bennett Park (0-1) | 19-23 | Lost 3 |
| » Starters: Joe McGinnity vs Win Mercer | Fifth | 6½ out |
| Thursday, June 12 |
| » Defeated Tigers (20-20), 9-3 | Bennett Park (1-1) | 20-23 | |
| » Starters: Harry Howell vs Joe Yeager | Fifth | 6½ out |
| Friday, June 13 |
| » Defeated Tigers (20-21), 4-0 | Bennett Park (2-1) | 21-23 | Won 2 |
| » Starters: Charlie Shields vs Roscoe Miller | Fifth | 6½ out |
| Saturday, June 14 |
| » Defeated Tigers (20-22), 9-2 | Bennett Park (3-1) | 22-23 | Won 3 |
| » Starters: Joe McGinnity vs Ed Siever | Fourth | 5½ out |
| Sunday, June 15 |
| » Lost to Browns (21-22), 9-4 | Sportsman's Park II (0-1) | 22-24 | |
| » Starters: Harry Howell vs Jack Harper | Fifth | 6 out |
| Monday, June 16 |
| » Lost to Browns (22-22), 6-5 | Sportsman's Park II (0-2) | 22-25 | Lost 2 |
| » Starters: Jack Cronin vs Red Donahue | Sixth | 7 out |
| Tuesday, June 17 |
| » Tied Browns, 2-2 | Sportsman's Park II (0-2) | 22-25 | |
| » Starters: Joe McGinnity vs Willie Sudhoff | Sixth | 7½ out |
| Wednesday, June 18 |
| » Lost to Browns (23-22), 9-6 | Sportsman's Park II (0-3) | 22-26 | Lost 3 |
| » Starters: Charlie Shields vs Jack Powell | Sixth | 8 out |
| Thursday, June 19 |
| » Lost to White Sox (29-16), 2-0 | South Side Park III (0-1) | 22-27 | Lost 4 |
| » Starters: Jack Cronin vs Nixey Callahan | Seventh | 9 out |
| Saturday, June 21 |
| » Lost to White Sox (30-16), 3-2 | South Side Park III (0-2) | 22-28 | Lost 5 |
| » Starters: Harry Howell vs Wiley Piatt | Seventh | 10 out |
| Sunday, June 22 |
| » Defeated White Sox (30-17), 3-2 | South Side Park III (1-2) | 23-28 | |
| » Starters: Joe McGinnity vs Roy Patterson | Fifth | 8 out |
| » Defeated White Sox (30-18), 2-1 | South Side Park III (2-2) | 24-28 | Won 2 |
| » Starters: Jack Cronin vs Ned Garvin | Fifth | 8 out |
| Tuesday, June 24 |
| » Defeated Athletics (25-24), 6-4 | Oriole Park IV (15-11) | 25-28 | Won 3 |
| » Starters: Eddie Plank vs Harry Howell | Fourth | 8½ out |
| Wednesday, June 25 |
| » Lost to Athletics (26-24), 8-6 | Oriole Park IV (15-12) | 25-29 | |
| » Starters: Bert Husting vs Joe McGinnity | Sixth | 9 out |
| Thursday, June 26 |
| » Defeated Athletics (26-25), 7-3 | Oriole Park IV (16-12) | 26-29 | |
| » Starters: Rube Waddell vs Jack Cronin | Fifth | 8 out |
| Friday, June 27 |
| » Lost to Red Sox (31-26), 6-3 | Oriole Park IV (16-13) | 26-30 | |
| » Starters: George Winter vs Harry Howell | Sixth | 8½ out |
| Saturday, June 28 |
| » Lost to Red Sox (32-26), 9-4 | Oriole Park IV (16-14) | 26-31 | Lost 2 |
| » Starters: Cy Young vs Joe McGinnity | Seventh | 9 out |
| Tuesday, July 1 |
| » Lost to Athletics (28-26), 2-0 | Columbia Park (1-4) | 26-32 | Lost 3 |
| » Manager: Wilbert Robinson |
| » Starters: Jack Cronin vs Rube Waddell | Seventh | 10 out |
| Wednesday, July 2 |
| » Defeated Athletics (28-27), 2-1 | Columbia Park (2-4) | 27-32 | |
| » Starters: Joe McGinnity vs Eddie Plank | Seventh | 8½ out |
| Friday, July 4 |
| » Lost to Red Sox (34-27), 5-3 | Huntington Ave Baseball Grounds (1-5) | 27-33 | |
| » Starters: Charlie Shields vs George Winter | Sixth | 11 out |
| » Lost to Red Sox (35-27), 5-4 | Huntington Ave Baseball Grounds (1-6) | 27-34 | Lost 2 |
| » Starters: Jack Cronin vs Cy Young | Sixth | 11 out |
| Saturday, July 5 |
| » Defeated Red Sox (35-28), 5-4 | Huntington Ave Baseball Grounds (2-6) | 28-34 | |
| » Starters: Joe McGinnity vs Bill Dinneen | Sixth | 11 out |
| Monday, July 7 |
| » Defeated Senators (29-35), 13-0 | Oriole Park IV (17-14) | 29-34 | Won 2 |
| » Starters: Al Orth vs Harry Howell | Fifth | 9½ out |
| Tuesday, July 8 |
| » Defeated Senators (29-36), 8-1 | Oriole Park IV (18-14) | 30-34 | Won 3 |
| » Starters: Al Orth vs Jack Cronin | Fifth | 9½ out |
| Wednesday, July 9 |
| » Defeated Senators (29-37), 11-4 | Oriole Park IV (19-14) | 31-34 | Won 4 |
| » Starters: Casey Patten vs Joe McGinnity | Fifth | 9 out |
| Thursday, July 10 |
| » Lost to Senators (30-37), 7-3 | American League Park I (2-2) | 31-35 | |
| » Starters: Harry Howell vs Bill Carrick | Fifth | 9½ out |
| Friday, July 11 |
| » Lost to Senators (31-37), 4-3 | American League Park I (2-3) | 31-36 | Lost 2 |
| » Starters: Jack Cronin vs Happy Townsend | Fifth | 10½ out |
| Saturday, July 12 |
| » Lost to Senators (32-37), 4-1 | American League Park I (2-4) | 31-37 | Lost 3 |
| » Starters: Joe McGinnity vs Al Orth | Sixth | 11½ out |
| Monday, July 14 |
| » Lost to Senators (33-37), 10-9 | American League Park I (2-5) | 31-38 | Lost 4 |
| » Starters: Charlie Shields vs Bill Carrick | Sixth | 12 out |
| Tuesday, July 15 |
| » Lost to Browns (36-31), 13-6 | Oriole Park IV (19-15) | 31-39 | Lost 5 |
| » Starters: Jack Powell vs Harry Howell | Seventh | 12 out |
| Wednesday, July 16 |
| » Lost to Browns (37-31), 6-5 | Oriole Park IV (19-16) | 31-40 | Lost 6 |
| » Starters: Jack Harper vs Charlie Shields | Seventh | 13 out |
| Thursday, July 17 |
| » Orioles forfeited to Browns. | Oriole Park IV (19-17) | 31-41 | Lost 7 |
| Friday, July 18 |
| » Lost to Browns (38-31), 4-3 | Oriole Park IV (19-18) | 31-42 | Lost 8 |
| » Starters: Willie Sudhoff vs Charlie Shields | Seventh | 12½ out |
| Saturday, July 19 |
| » Defeated Tigers (29-42), 2-1 | Oriole Park IV (20-18) | 32-42 | |
| » Starters: Win Mercer vs Harry Howell | Seventh | 11½ out |
| Monday, July 21 |
| » Lost to Tigers (30-42), 8-0 | Oriole Park IV (20-19) | 32-43 | |
| » Starters: Ed Siever vs Snake Wiltse | Sixth | 11½ out |
| Tuesday, July 22 |
| » Lost to Tigers (31-42), 7-5 | Oriole Park IV (20-20) | 32-44 | Lost 2 |
| » Starters: George Mullin vs George Prentiss | Sixth | 11½ out |
| Wednesday, July 23 |
| » Defeated White Sox (42-31), 7-5 | Oriole Park IV (21-20) | 33-44 | |
| » Starters: Ned Garvin vs Charlie Shields | Seventh | 10½ out |
| Friday, July 25 |
| » Lost to White Sox (43-31), 15-4 | Oriole Park IV (21-21) | 33-45 | |
| » Starters: Roy Patterson vs Harry Howell | Seventh | 10½ out |
| » Defeated White Sox (43-32), 5-4 | Oriole Park IV (22-21) | 34-45 | |
| » Starters: Clark Griffith vs Snake Wiltse | Seventh | 10½ out |
| Saturday, July 26 |
| » Defeated Indians (36-45), 9-8 | Oriole Park IV (23-21) | 35-45 | Won 2 |
| » Starters: Earl Moore vs Charlie Shields | Seventh | 10½ out |
| Monday, July 28 |
| » Defeated Indians (36-46), 15-5 | Oriole Park IV (24-21) | 36-45 | Won 3 |
| » Starters: Bill Bernhard vs Snake Wiltse | Sixth | 9½ out |
| Tuesday, July 29 |
| » Defeated Indians (36-47), 8-7 | Oriole Park IV (25-21) | 37-45 | Won 4 |
| » Starters: Dike Varney vs George Prentiss | Sixth | 8½ out |
| Friday, August 1 |
| » Lost to White Sox (45-35), 7-6 | South Side Park III (2-3) | 37-46 | |
| » Starters: Snake Wiltse vs Wiley Piatt | Seventh | 9 out |
| Saturday, August 2 |
| » Lost to White Sox (46-35), 8-3 | South Side Park III (2-4) | 37-47 | Lost 2 |
| » Starters: Harry Howell vs Nixey Callahan | Seventh | 11 out |
| » Lost to White Sox (47-35), 5-2 | South Side Park III (2-5) | 37-48 | Lost 3 |
| » Starters: Dad Hale vs Clark Griffith | Seventh | 11 out |
| Sunday, August 3 |
| » Lost to Browns (44-37), 9-3 | Sportsman's Park II (0-4) | 37-49 | Lost 4 |
| » Starters: Charlie Shields vs Jack Harper | Eighth | 12 out |
| Monday, August 4 |
| » Lost to Browns (45-37), 8-2 | Sportsman's Park II (0-5) | 37-50 | Lost 5 |
| » Starters: Snake Wiltse vs Red Donahue | Eighth | 13 out |
| Tuesday, August 5 |
| » Lost to Browns (46-37), 8-7 | Sportsman's Park II (0-6) | 37-51 | Lost 6 |
| » Starters: Ike Butler vs Willie Sudhoff | Eighth | 13 out |
| Wednesday, August 6 |
| » Defeated Tigers (37-47), 2-1 | Bennett Park (4-1) | 38-51 | |
| » Starters: Snake Wiltse vs George Mullin | Eighth | 13 out |
| Friday, August 8 |
| » Lost to Tigers (38-47), 2-0 | Bennett Park (4-2) | 38-52 | |
| » Starters: Charlie Shields vs Ed Siever | Eighth | 12½ out |
| Saturday, August 9 |
| » Lost to Indians (44-49), 7-0 | League Park I (0-4) | 38-53 | Lost 2 |
| » Starters: Jack Katoll vs Charlie Smith | Eighth | 13½ out |
| Monday, August 11 |
| » Lost to Indians (45-49), 17-11 | League Park I (0-5) | 38-54 | Lost 3 |
| » Starters: Dad Hale vs Gene Wright | Eighth | 14 out |
| Tuesday, August 12 |
| » Lost to Indians (46-49), 6-3 | League Park I (0-6) | 38-55 | Lost 4 |
| » Starters: Ike Butler vs Earl Moore | Eighth | 14½ out |
| Wednesday, August 13 |
| » Defeated Indians (46-50), 14-4 | Oriole Park IV (26-21) | 39-55 | |
| » Starters: Charlie Smith vs Harry Howell | Eighth | 13½ out |
| Thursday, August 14 |
| » Defeated Indians (46-51), 8-7 | Oriole Park IV (27-21) | 40-55 | Won 2 |
| » Starters: Charlie Hickman vs Charlie Shields | Seventh | 13 out |
| Friday, August 15 |
| » Lost to Indians (47-51), 5-1 | Oriole Park IV (27-22) | 40-56 | |
| » Starters: Bill Bernhard vs Ike Butler | Seventh | 13½ out |
| Saturday, August 16 |
| » Lost to Browns (52-41), 12-5 | Oriole Park IV (27-23) | 40-57 | Lost 2 |
| » Starters: Jack Powell vs Charlie Shields | Seventh | 14½ out |
| Monday, August 18 |
| » Defeated Browns (52-42), 11-1 | Oriole Park IV (28-23) | 41-57 | |
| » Starters: Jack Harper vs Jack Katoll | Seventh | 14½ out |
| Tuesday, August 19 |
| » Lost to Browns (53-42), 11-4 | Oriole Park IV (28-24) | 41-58 | |
| » Starters: Red Donahue vs Ike Butler | Seventh | 14½ out |
| Wednesday, August 20 |
| » Defeated Tigers (39-57), 7-6 | Oriole Park IV (29-24) | 42-58 | |
| » Starters: Joe Yeager vs Snake Wiltse | Seventh | 14½ out |
| Thursday, August 21 |
| » Defeated Tigers (39-58), 6-5 | Oriole Park IV (30-24) | 43-58 | Won 2 |
| » Starters: Ed Siever vs Jack Katoll | Seventh | 14½ out |
| Friday, August 22 |
| » Lost to Tigers (40-58), 10-2 | Oriole Park IV (30-25) | 43-59 | |
| » Starters: George Mullin vs Charlie Shields | Seventh | 15½ out |
| Saturday, August 23 |
| » Defeated White Sox (55-46), 14-8 | Oriole Park IV (31-25) | 44-59 | |
| » Starters: Wiley Piatt vs Ike Butler | Seventh | 15½ out |
| Monday, August 25 |
| » Defeated White Sox (55-47), 21-6 | Oriole Park IV (32-25) | 45-59 | Won 2 |
| » Starters: Clark Griffith vs Snake Wiltse | Seventh | 15½ out |
| Tuesday, August 26 |
| » Lost to White Sox (56-47), 10-0 | Oriole Park IV (32-26) | 45-60 | |
| » Starters: Ned Garvin vs Harry Howell | Sixth | 16½ out |
| Thursday, August 28 |
| » Lost to Browns (54-48), 1-0 | Sportsman's Park II (0-7) | 45-61 | Lost 2 |
| » Starters: Jack Katoll vs Red Donahue | Seventh | 16½ out |
| Friday, August 29 |
| » Lost to Browns (55-48), 7-1 | Sportsman's Park II (0-8) | 45-62 | Lost 3 |
| » Starters: Crese Heismann vs Jack Powell | Seventh | 18 out |
| » Lost to Browns (56-48), 4-2 | Sportsman's Park II (0-9) | 45-63 | Lost 4 |
| » Starters: Harry Howell vs Willie Sudhoff | Seventh | 18 out |
| Saturday, August 30 |
| » Lost to Browns (57-48), 8-2 | Sportsman's Park II (0-10) | 45-64 | Lost 5 |
| » Starters: Snake Wiltse vs Jack Harper | Seventh | 18½ out |
| Sunday, August 31 |
| » Lost to White Sox (59-50), 11-2 | South Side Park III (2-6) | 45-65 | Lost 6 |
| » Starters: Jack Katoll vs Nixey Callahan | Seventh | 18 out |
| Monday, September 1 |
| » Lost to White Sox (60-50), 8-4 | South Side Park III (2-7) | 45-66 | Lost 7 |
| » Starters: Ike Butler vs Wiley Piatt | Seventh | 17½ out |
| » Tied White Sox, 5-5 | South Side Park III (2-7) | 45-66 | |
| » Starters: Snake Wiltse vs Clark Griffith | Seventh | 17½ out |
| Tuesday, September 2 |
| » Lost to Indians (58-57), 23-7 | League Park I (0-7) | 45-67 | Lost 8 |
| » Starters: Jack Katoll vs Addie Joss | Seventh | 18½ out |
| Wednesday, September 3 |
| » Lost to Indians (59-57), 8-6 | League Park I (0-8) | 45-68 | Lost 9 |
| » Starters: Crese Heismann vs Otto Hess | Seventh | 19½ out |
| Thursday, September 4 |
| » Lost to Indians (60-57), 7-5 | League Park I (0-9) | 45-69 | Lost 10 |
| » Starters: Crese Heismann vs Jack Lundbom | Seventh | 20½ out |
| Friday, September 5 |
| » Defeated Tigers (43-69), 15-1 | Bennett Park (5-2) | 46-69 | |
| » Starters: Snake Wiltse vs Win Mercer | Seventh | 19½ out |
| Saturday, September 6 |
| » Lost to Tigers (44-69), 12-4 | Bennett Park (5-3) | 46-70 | |
| » Starters: Ike Butler vs George Mullin | Seventh | 21 out |
| » Lost to Tigers (45-69), 6-2 | Bennett Park (5-4) | 46-71 | Lost 2 |
| » Starters: Jack Katoll vs Joe Yeager | Seventh | 21 out |
| Sunday, September 7 |
| » Lost to Tigers (46-69), 11-6 | Burns Park (0-1) | 46-72 | Lost 3 |
| » Starters: Snake Wiltse vs Wish Egan | Eighth | 21½ out |
| Monday, September 8 |
| » Major-league debuts: Jimmy Sebring (Pirates) |
| Wednesday, September 10 |
| » Lost to Athletics (69-49), 9-5 | Columbia Park (2-5) | 46-73 | Lost 4 |
| » Starters: Ike Butler vs Fred Mitchell | Eighth | 24 out |
| » Lost to Athletics (70-49), 5-4 | Columbia Park (2-6) | 46-74 | Lost 5 |
| » Starters: Jack Katoll vs Bert Husting | Eighth | 24 out |
| Thursday, September 11 |
| » Lost to Athletics (71-49), 9-1 | Columbia Park (2-7) | 46-75 | Lost 6 |
| » Starters: Snake Wiltse vs Eddie Plank | Eighth | 26 out |
| » Lost to Athletics (72-49), 4-3 | Columbia Park (2-8) | 46-76 | Lost 7 |
| » Starters: Ike Butler vs Highball Wilson | Eighth | 26 out |
| Friday, September 12 |
| » Lost to Senators (56-68), 15-1 | Oriole Park IV (32-27) | 46-77 | Lost 8 |
| » Starters: Watty Lee vs Jack Katoll | Eighth | 26 out |
| Sunday, September 14 |
| » Major-league debuts: Jim Hackett and Art Weaver (Cardinals) |
| Monday, September 15 |
| » Lost to Senators (57-68), 11-8 | Oriole Park IV (32-28) | 46-78 | Lost 9 |
| » Starters: Al Orth vs Snake Wiltse | Eighth | 27½ out |
| » Tied Senators, 4-4 | Oriole Park IV (32-28) | 46-78 | |
| » Starters: Happy Townsend vs Ike Butler | Eighth | 27½ out |
| Tuesday, September 16 |
| » Lost to Red Sox (70-55), 7-2 | Huntington Ave Baseball Grounds (2-7) | 46-79 | Lost 10 |
| » Starters: Jack Katoll vs Tully Sparks | Eighth | 28½ out |
| Wednesday, September 17 |
| » Lost to Red Sox (71-55), 13-1 | Huntington Ave Baseball Grounds (2-8) | 46-80 | Lost 11 |
| » Starters: Ike Butler vs Tom Hughes | Eighth | 29 out |
| » Defeated Red Sox (71-56), 5-4 | Huntington Ave Baseball Grounds (3-8) | 47-80 | |
| » Starters: Ernie Ross vs Nick Altrock | Eighth | 29 out |
| Thursday, September 18 |
| » Lost to Red Sox (72-56), 5-2 | Huntington Ave Baseball Grounds (3-9) | 47-81 | |
| » Starters: Snake Wiltse vs Bill Dinneen | Eighth | 30 out |
| Saturday, September 20 |
| » Defeated Senators (57-72), 6-5 | American League Park I (3-5) | 48-81 | |
| » Starters: Jack Katoll vs Al Orth | Seventh | 30 out |
| » Defeated Senators (57-73), 9-6 | American League Park I (4-5) | 49-81 | Won 2 |
| » Starters: Ike Butler vs Bill Carrick | Seventh | 30 out |
| Monday, September 22 |
| » Defeated Senators (57-74), 9-4 | American League Park I (5-5) | 50-81 | Won 3 |
| » Starters: Snake Wiltse vs Watty Lee | Seventh | 30 out |
| » Lost to Senators (58-74), 14-3 | American League Park I (5-6) | 50-82 | |
| » Starters: Ernie Ross vs Happy Townsend | Seventh | 30 out |
| Tuesday, September 23 |
| » Lost to Athletics (81-51), 4-3 | Columbia Park (2-9) | 50-83 | Lost 2 |
| » Starters: Jack Katoll vs Eddie Plank | Seventh | 31 out |
| Wednesday, September 24 |
| » Lost to Athletics (82-51), 7-5 | Columbia Park (2-10) | 50-84 | Lost 3 |
| » Starters: Ike Butler vs Andy Coakley | Eighth | 33 out |
| » Lost to Athletics (83-51), 5-4 | Columbia Park (2-11) | 50-85 | Lost 4 |
| » Starters: Snake Wiltse vs Highball Wilson | Eighth | 33 out |
| Saturday, September 27 |
| » Lost to Red Sox (75-60), 9-8 | Oriole Park IV (32-29) | 50-86 | Lost 5 |
| » Starters: Tom Hughes vs Jack Katoll | Eighth | 33 out |
| » Lost to Red Sox (76-60), 4-2 | Oriole Park IV (32-30) | 50-87 | Lost 6 |
| » Starters: Bill Dinneen vs Ike Butler | Eighth | 33 out |
| Monday, September 29 |
| » Lost to Red Sox (77-60), 9-5 | Oriole Park IV (32-31) | 50-88 | Lost 7 |
| » Starters: Tully Sparks vs Ike Butler | Eighth | 33½ out |
| Sunday, October 5 |
| » Major-league debuts: Otto Williams (Cardinals) |
Game information provided by Retrosheet (www.retrosheet.org) |